http://togogenome.org/gene/83332:Rv1311 ^@ http://purl.uniprot.org/uniprot/P9WPV1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Strand|||Turn ^@ ATP synthase epsilon chain|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000188166 http://togogenome.org/gene/83332:Rv2156c ^@ http://purl.uniprot.org/uniprot/P9WMW7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Phospho-N-acetylmuramoyl-pentapeptide-transferase ^@ http://purl.uniprot.org/annotation/PRO_0000108856 http://togogenome.org/gene/83332:Rv1811 ^@ http://purl.uniprot.org/uniprot/I6YBN6 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3348 ^@ http://purl.uniprot.org/uniprot/P96234 ^@ Region ^@ Domain Extent ^@ DEDD_Tnp_IS110 ^@ http://togogenome.org/gene/83332:Rv1982c ^@ http://purl.uniprot.org/uniprot/P9WF65 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC36 ^@ http://purl.uniprot.org/annotation/PRO_0000221201 http://togogenome.org/gene/83332:Rv0872c ^@ http://purl.uniprot.org/uniprot/Q79FV3 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3660c ^@ http://purl.uniprot.org/uniprot/P9WKX7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3660c ^@ http://purl.uniprot.org/annotation/PRO_0000390676 http://togogenome.org/gene/83332:Rv2271 ^@ http://purl.uniprot.org/uniprot/P9WLF7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2271 ^@ http://purl.uniprot.org/annotation/PRO_0000103997 http://togogenome.org/gene/83332:Rv0885 ^@ http://purl.uniprot.org/uniprot/P9WKQ5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0885 ^@ http://purl.uniprot.org/annotation/PRO_0000103727 http://togogenome.org/gene/83332:Rv2638 ^@ http://purl.uniprot.org/uniprot/I6X4W0 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Putative anti-anti-sigma factor Rv2638|||STAS ^@ http://purl.uniprot.org/annotation/PRO_0000451031 http://togogenome.org/gene/83332:Rv3832c ^@ http://purl.uniprot.org/uniprot/P96246 ^@ Region ^@ Domain Extent ^@ Methyltransf_11 ^@ http://togogenome.org/gene/83332:Rv3470c ^@ http://purl.uniprot.org/uniprot/O06335 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative acetolactate synthase large subunit IlvB2 ^@ http://purl.uniprot.org/annotation/PRO_0000396952 http://togogenome.org/gene/83332:Rv0347 ^@ http://purl.uniprot.org/uniprot/O06298 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2097c ^@ http://purl.uniprot.org/uniprot/P9WNU7 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ Abolishes pupylation.|||Proton acceptor|||Pup--protein ligase ^@ http://purl.uniprot.org/annotation/PRO_0000103966 http://togogenome.org/gene/83332:Rv3664c ^@ http://purl.uniprot.org/uniprot/L0TEV4 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://purl.uniprot.org/annotation/PRO_5003948398 http://togogenome.org/gene/83332:Rv1212c ^@ http://purl.uniprot.org/uniprot/P9WMZ1 ^@ Molecule Processing ^@ Chain ^@ Alpha-maltose-1-phosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000413978 http://togogenome.org/gene/83332:Rv0173 ^@ http://purl.uniprot.org/uniprot/O07417 ^@ Region ^@ Domain Extent ^@ MlaD ^@ http://togogenome.org/gene/83332:Rv3136 ^@ http://purl.uniprot.org/uniprot/P9WHY3 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N-acetylmethionine|||Uncharacterized PPE family protein PPE51 ^@ http://purl.uniprot.org/annotation/PRO_0000378485 http://togogenome.org/gene/83332:Rv1006 ^@ http://purl.uniprot.org/uniprot/O05592 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ F5/8 type C domain-containing protein ^@ http://purl.uniprot.org/annotation/PRO_5010328432 http://togogenome.org/gene/83332:Rv0828c ^@ http://purl.uniprot.org/uniprot/O53839 ^@ Region ^@ Domain Extent ^@ CMP/dCMP-type deaminase ^@ http://togogenome.org/gene/83332:Rv3031 ^@ http://purl.uniprot.org/uniprot/P9WQ27 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Nucleophile|||Probable 1,4-alpha-glucan branching enzyme Rv3031|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000413972 http://togogenome.org/gene/83332:Rv1671 ^@ http://purl.uniprot.org/uniprot/O53918 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1159 ^@ http://purl.uniprot.org/uniprot/P9WN01 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000393738 http://togogenome.org/gene/83332:Rv0791c ^@ http://purl.uniprot.org/uniprot/I6X9T8 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv2506 ^@ http://purl.uniprot.org/uniprot/O06169 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1501 ^@ http://purl.uniprot.org/uniprot/P9WI91 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1501 ^@ http://purl.uniprot.org/annotation/PRO_0000215234 http://togogenome.org/gene/83332:Rv0973c ^@ http://purl.uniprot.org/uniprot/P71538 ^@ Region ^@ Domain Extent ^@ ATP-grasp|||Biotin carboxylation|||Lipoyl-binding ^@ http://togogenome.org/gene/83332:Rv2681 ^@ http://purl.uniprot.org/uniprot/I6XF17 ^@ Region ^@ Domain Extent ^@ HRDC ^@ http://togogenome.org/gene/83332:Rv1465 ^@ http://purl.uniprot.org/uniprot/O53156 ^@ Region ^@ Domain Extent ^@ NifU_N ^@ http://togogenome.org/gene/83332:Rv2326c ^@ http://purl.uniprot.org/uniprot/P9WQI7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ ABC transporter 1|||ABC transporter 2|||Helical|||Uncharacterized ABC transporter ATP-binding protein Rv2326c ^@ http://purl.uniprot.org/annotation/PRO_0000093266 http://togogenome.org/gene/83332:Rv2644c ^@ http://purl.uniprot.org/uniprot/P9WL53 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2644c ^@ http://purl.uniprot.org/annotation/PRO_0000104078 http://togogenome.org/gene/83332:Rv3155 ^@ http://purl.uniprot.org/uniprot/P9WIX3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||NADH-quinone oxidoreductase subunit K ^@ http://purl.uniprot.org/annotation/PRO_0000118532 http://togogenome.org/gene/83332:Rv1982A ^@ http://purl.uniprot.org/uniprot/P9WJ29 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB36 ^@ http://purl.uniprot.org/annotation/PRO_0000408078 http://togogenome.org/gene/83332:Rv2976c ^@ http://purl.uniprot.org/uniprot/P9WFQ9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||Uracil-DNA glycosylase ^@ http://purl.uniprot.org/annotation/PRO_0000176119 http://togogenome.org/gene/83332:Rv3842c ^@ http://purl.uniprot.org/uniprot/P9WMU3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ GP-PDE|||Probable glycerophosphodiester phosphodiesterase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000392941 http://togogenome.org/gene/83332:Rv0470A ^@ http://purl.uniprot.org/uniprot/L7N651 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1103c ^@ http://purl.uniprot.org/uniprot/O53451 ^@ Molecule Processing ^@ Chain ^@ Antitoxin MazE3 ^@ http://purl.uniprot.org/annotation/PRO_0000406298 http://togogenome.org/gene/83332:Rv3299c ^@ http://purl.uniprot.org/uniprot/O65931 ^@ Modification|||Region ^@ Domain Extent|||Modified Residue ^@ 3-oxoalanine (Cys)|||Sulfatase ^@ http://togogenome.org/gene/83332:Rv3674c ^@ http://purl.uniprot.org/uniprot/P9WQ11 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Endonuclease III|||HhH ^@ http://purl.uniprot.org/annotation/PRO_0000102219 http://togogenome.org/gene/83332:Rv3121 ^@ http://purl.uniprot.org/uniprot/P9WPL7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Transmembrane ^@ Helical|||Putative cytochrome P450 141|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052303 http://togogenome.org/gene/83332:Rv0009 ^@ http://purl.uniprot.org/uniprot/P9WHW3 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ PPIase cyclophilin-type|||Peptidyl-prolyl cis-trans isomerase A ^@ http://purl.uniprot.org/annotation/PRO_0000064209 http://togogenome.org/gene/83332:Rv3638 ^@ http://purl.uniprot.org/uniprot/I6XHU7 ^@ Region ^@ Domain Extent ^@ IstB_IS21 ^@ http://togogenome.org/gene/83332:Rv0526 ^@ http://purl.uniprot.org/uniprot/O06392 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_5004156822 http://togogenome.org/gene/83332:Rv2590 ^@ http://purl.uniprot.org/uniprot/Q50631 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Modified Residue ^@ Carboxylic acid reductase|||Carrier|||O-(pantetheine 4'-phosphoryl)serine ^@ http://purl.uniprot.org/annotation/PRO_0000451306 http://togogenome.org/gene/83332:Rv0488 ^@ http://purl.uniprot.org/uniprot/P9WK33 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative amino-acid transporter Rv0488 ^@ http://purl.uniprot.org/annotation/PRO_0000103692 http://togogenome.org/gene/83332:Rv0316 ^@ http://purl.uniprot.org/uniprot/O07243 ^@ Region ^@ Domain Extent ^@ MIase ^@ http://togogenome.org/gene/83332:Rv2025c ^@ http://purl.uniprot.org/uniprot/P9WGF5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable cation efflux system protein Rv2025c ^@ http://purl.uniprot.org/annotation/PRO_0000419181 http://togogenome.org/gene/83332:Rv1497 ^@ http://purl.uniprot.org/uniprot/P71778 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ 60% loss of esterase activity.|||70% loss of esterase activity.|||80% loss of esterase and beta-lactamase activities.|||90% loss of esterase activity.|||Acyl-ester intermediate|||Almost no change in esterase and beta-lactamase activities.|||Esterase/beta-lactamase LipL|||Loss of esterase and beta-lactamase activities. ^@ http://purl.uniprot.org/annotation/PRO_0000448854 http://togogenome.org/gene/83332:Rv0127 ^@ http://purl.uniprot.org/uniprot/O07177 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Maltokinase ^@ http://purl.uniprot.org/annotation/PRO_0000412894 http://togogenome.org/gene/83332:Rv3247c ^@ http://purl.uniprot.org/uniprot/P9WKE1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mass|||Strand ^@ Thymidylate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000155309 http://togogenome.org/gene/83332:Rv0493c ^@ http://purl.uniprot.org/uniprot/P9WKU7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0493c ^@ http://purl.uniprot.org/annotation/PRO_0000103694 http://togogenome.org/gene/83332:Rv1321 ^@ http://purl.uniprot.org/uniprot/P9WIY5 ^@ Molecule Processing ^@ Chain ^@ Endonuclease NucS ^@ http://purl.uniprot.org/annotation/PRO_0000155685 http://togogenome.org/gene/83332:Rv0986 ^@ http://purl.uniprot.org/uniprot/P9WQK1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Uncharacterized ABC transporter ATP-binding protein Rv0986 ^@ http://purl.uniprot.org/annotation/PRO_0000093254 http://togogenome.org/gene/83332:Rv2170 ^@ http://purl.uniprot.org/uniprot/O53504 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv2461c ^@ http://purl.uniprot.org/uniprot/P9WPC5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ ATP-dependent Clp protease proteolytic subunit 1|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000179596 http://togogenome.org/gene/83332:Rv1993c ^@ http://purl.uniprot.org/uniprot/P9WLP5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1993c ^@ http://purl.uniprot.org/annotation/PRO_0000103920 http://togogenome.org/gene/83332:Rv0959A ^@ http://purl.uniprot.org/uniprot/P9WJ55 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB9 ^@ http://purl.uniprot.org/annotation/PRO_0000408058 http://togogenome.org/gene/83332:Rv2823c ^@ http://purl.uniprot.org/uniprot/P71629 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)|||GGDEF|||HD ^@ http://purl.uniprot.org/annotation/PRO_0000418224 http://togogenome.org/gene/83332:Rv3670 ^@ http://purl.uniprot.org/uniprot/I6YCQ4 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv0895 ^@ http://purl.uniprot.org/uniprot/P9WKA3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv0895 ^@ http://purl.uniprot.org/annotation/PRO_0000222906 http://togogenome.org/gene/83332:Rv2284 ^@ http://purl.uniprot.org/uniprot/Q50681 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Transmembrane ^@ Helical|||Probable carboxylic ester hydrolase LipM ^@ http://purl.uniprot.org/annotation/PRO_0000448852 http://togogenome.org/gene/83332:Rv3425 ^@ http://purl.uniprot.org/uniprot/Q50703 ^@ Molecule Processing ^@ Chain ^@ PPE family protein PPE57 ^@ http://purl.uniprot.org/annotation/PRO_0000217853 http://togogenome.org/gene/83332:Rv3485c ^@ http://purl.uniprot.org/uniprot/O06348 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2113 ^@ http://purl.uniprot.org/uniprot/O33248 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2057c ^@ http://purl.uniprot.org/uniprot/P9WH97 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L33 1 ^@ http://purl.uniprot.org/annotation/PRO_0000170194 http://togogenome.org/gene/83332:Rv2939 ^@ http://purl.uniprot.org/uniprot/P9WIN5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 4-fold decrease in affinity for acylated mas protein. No change in catalytic activity.|||40-fold decrease in affinity for acylated mas protein. No change in catalytic activity.|||65-fold decrease in activity.|||76-fold decrease in activity.|||About 2-fold decrease in activity.|||Less than 1.9-fold decrease in activity.|||N-acetylmethionine|||Phosphothreonine|||Phthiocerol/phthiodiolone dimycocerosyl transferase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000058229 http://togogenome.org/gene/83332:Rv1016c ^@ http://purl.uniprot.org/uniprot/P9WK59 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LpqT|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018131 http://togogenome.org/gene/83332:Rv1509 ^@ http://purl.uniprot.org/uniprot/P9WLW3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1509 ^@ http://purl.uniprot.org/annotation/PRO_0000103863 http://togogenome.org/gene/83332:Rv3041c ^@ http://purl.uniprot.org/uniprot/I6YF11 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv0843 ^@ http://purl.uniprot.org/uniprot/I6XWE5 ^@ Region ^@ Domain Extent ^@ E1_dh ^@ http://togogenome.org/gene/83332:Rv1681 ^@ http://purl.uniprot.org/uniprot/O33183 ^@ Region ^@ Domain Extent ^@ Radical SAM core ^@ http://togogenome.org/gene/83332:Rv1171 ^@ http://purl.uniprot.org/uniprot/O50427 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1332 ^@ http://purl.uniprot.org/uniprot/P9WM25 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1332 ^@ http://purl.uniprot.org/annotation/PRO_0000103805 http://togogenome.org/gene/83332:Rv1513 ^@ http://purl.uniprot.org/uniprot/P71792 ^@ Region ^@ Domain Extent ^@ Methyltransf_21 ^@ http://togogenome.org/gene/83332:Rv2338c ^@ http://purl.uniprot.org/uniprot/P95234 ^@ Region ^@ Domain Extent ^@ ThiF ^@ http://togogenome.org/gene/83332:Rv2344c ^@ http://purl.uniprot.org/uniprot/P9WNY7 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ Basic and acidic residues|||Deoxyguanosinetriphosphate triphosphohydrolase-like protein|||HD|||N-acetylserine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000205310 http://togogenome.org/gene/83332:Rv2386c ^@ http://purl.uniprot.org/uniprot/P9WFX1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ No activity is observed.|||Only the chorismate mutase activity is observed.|||Proton donor|||Salicylate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000262086 http://togogenome.org/gene/83332:Rv3166c ^@ http://purl.uniprot.org/uniprot/O53316 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ DUF4129|||Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1816 ^@ http://purl.uniprot.org/uniprot/P9WMC9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Transmembrane|||Turn ^@ HTH tetR-type|||Helical|||Uncharacterized HTH-type transcriptional regulator Rv1816 ^@ http://purl.uniprot.org/annotation/PRO_0000070666 http://togogenome.org/gene/83332:Rv3354 ^@ http://purl.uniprot.org/uniprot/O50383 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ DUF732|||DUF732 domain-containing protein ^@ http://purl.uniprot.org/annotation/PRO_5030174823 http://togogenome.org/gene/83332:Rv2986c ^@ http://purl.uniprot.org/uniprot/P9WMK7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Initiator Methionine|||Modified Residue|||Propeptide|||Sequence Conflict|||Strand|||Turn ^@ Basic residues|||DNA-binding protein HU homolog|||DNA-binding protein HU homolog, propeptide removed|||N-acetylmethionine|||Removed|||Removed; alternate ^@ http://purl.uniprot.org/annotation/PRO_0000104950|||http://purl.uniprot.org/annotation/PRO_0000455388|||http://purl.uniprot.org/annotation/PRO_0000455389 http://togogenome.org/gene/83332:Rv3852 ^@ http://purl.uniprot.org/uniprot/I6YHB0 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv1116 ^@ http://purl.uniprot.org/uniprot/O06568 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv3311 ^@ http://purl.uniprot.org/uniprot/O53362 ^@ Region ^@ Compositionally Biased Region ^@ Acidic residues ^@ http://togogenome.org/gene/83332:Rv1629 ^@ http://purl.uniprot.org/uniprot/P9WNU5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ 3'-5' exonuclease|||5'-3' exonuclease|||DNA polymerase I ^@ http://purl.uniprot.org/annotation/PRO_0000101247 http://togogenome.org/gene/83332:Rv3685c ^@ http://purl.uniprot.org/uniprot/P9WPM5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 137|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052296 http://togogenome.org/gene/83332:Rv3134c ^@ http://purl.uniprot.org/uniprot/P9WFD3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Universal stress protein Rv3134c ^@ http://purl.uniprot.org/annotation/PRO_0000392630 http://togogenome.org/gene/83332:Rv1771 ^@ http://purl.uniprot.org/uniprot/P9WIT3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ FAD-binding PCMH-type|||L-gulono-1,4-lactone dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000420410 http://togogenome.org/gene/83332:Rv0539 ^@ http://purl.uniprot.org/uniprot/P9WMY1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized glycosyltransferase Rv0539 ^@ http://purl.uniprot.org/annotation/PRO_0000059248 http://togogenome.org/gene/83332:Rv0499 ^@ http://purl.uniprot.org/uniprot/P9WKT9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ DAGKc|||Uncharacterized protein Rv0499 ^@ http://purl.uniprot.org/annotation/PRO_0000103703 http://togogenome.org/gene/83332:Rv1218c ^@ http://purl.uniprot.org/uniprot/O86311 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Multidrug efflux system ATP-binding protein Rv1218c ^@ http://purl.uniprot.org/annotation/PRO_0000447330 http://togogenome.org/gene/83332:Rv0677c ^@ http://purl.uniprot.org/uniprot/P9WJS7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Siderophore export accessory protein MmpS5 ^@ http://purl.uniprot.org/annotation/PRO_0000216160 http://togogenome.org/gene/83332:Rv0327c ^@ http://purl.uniprot.org/uniprot/P9WPN1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 135A1|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052292 http://togogenome.org/gene/83332:Rv1182 ^@ http://purl.uniprot.org/uniprot/P9WIK5 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mass ^@ Acyltransferase PapA3 ^@ http://purl.uniprot.org/annotation/PRO_0000420764 http://togogenome.org/gene/83332:Rv3800c ^@ http://purl.uniprot.org/uniprot/I6X8D2 ^@ Experimental Information|||Modification|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Sequence Variant|||Strand|||Turn ^@ Acyl-ester intermediate; for acyltransferase activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase activity|||Cannot form alpha-alkyl beta-ketoacids derivatives.|||Carrier 1|||Carrier 2|||Confers thiophene resistance.|||Coumestan resistant.|||For beta-ketoacyl synthase activity|||For thioesterase-like activity|||Ketosynthase family 3 (KS3)|||O-(pantetheine 4'-phosphoryl)serine|||Polyketide synthase Pks13 ^@ http://purl.uniprot.org/annotation/PRO_0000451588 http://togogenome.org/gene/83332:Rv3257c ^@ http://purl.uniprot.org/uniprot/O86374 ^@ Region ^@ Domain Extent ^@ PGM_PMM_I|||PGM_PMM_II|||PGM_PMM_III|||PGM_PMM_IV ^@ http://togogenome.org/gene/83332:Rv0138 ^@ http://purl.uniprot.org/uniprot/P96815 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv0503c ^@ http://purl.uniprot.org/uniprot/P9WPB5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand ^@ Cyclopropane mycolic acid synthase 2|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000089569 http://togogenome.org/gene/83332:Rv2180c ^@ http://purl.uniprot.org/uniprot/O53514 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2531c ^@ http://purl.uniprot.org/uniprot/I6X4K0 ^@ Region ^@ Domain Extent ^@ OKR_DC_1 ^@ http://togogenome.org/gene/83332:Rv2695 ^@ http://purl.uniprot.org/uniprot/I6Y1I1 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv0799c ^@ http://purl.uniprot.org/uniprot/I6Y4U9 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ Dye-decolorizing peroxidase|||Protein no longer targeted to encapsulin nanocompartments, retains enzyme activity.|||Proton acceptor|||proximal binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000455327 http://togogenome.org/gene/83332:Rv1040c ^@ http://purl.uniprot.org/uniprot/L7N667 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE|||PPE-SVP ^@ http://purl.uniprot.org/annotation/PRO_5030173468 http://togogenome.org/gene/83332:Rv0626 ^@ http://purl.uniprot.org/uniprot/P9WF19 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ Putative antitoxin VapB5 ^@ http://purl.uniprot.org/annotation/PRO_0000408046 http://togogenome.org/gene/83332:Rv3364c ^@ http://purl.uniprot.org/uniprot/O50393 ^@ Molecule Processing ^@ Chain ^@ Serine protease inhibitor Rv3364c ^@ http://purl.uniprot.org/annotation/PRO_0000438185 http://togogenome.org/gene/83332:Rv1127c ^@ http://purl.uniprot.org/uniprot/O06579 ^@ Region ^@ Domain Extent ^@ PEP-utilizers|||PPDK_N ^@ http://togogenome.org/gene/83332:Rv3321c ^@ http://purl.uniprot.org/uniprot/P9WJ17 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB44 ^@ http://purl.uniprot.org/annotation/PRO_0000408084 http://togogenome.org/gene/83332:Rv0905 ^@ http://purl.uniprot.org/uniprot/P9WNP1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Probable enoyl-CoA hydratase EchA6 ^@ http://purl.uniprot.org/annotation/PRO_0000109335 http://togogenome.org/gene/83332:Rv2294 ^@ http://purl.uniprot.org/uniprot/P9WQ83 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Putative cystathionine beta-lyase ^@ http://purl.uniprot.org/annotation/PRO_0000163850 http://togogenome.org/gene/83332:Rv3511 ^@ http://purl.uniprot.org/uniprot/Q6MWW8 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3147 ^@ http://purl.uniprot.org/uniprot/P9WJH3 ^@ Molecule Processing ^@ Chain ^@ NADH-quinone oxidoreductase subunit C ^@ http://purl.uniprot.org/annotation/PRO_0000118670 http://togogenome.org/gene/83332:Rv2127 ^@ http://purl.uniprot.org/uniprot/P9WQM9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||L-asparagine permease 1 ^@ http://purl.uniprot.org/annotation/PRO_0000054189 http://togogenome.org/gene/83332:Rv0020c ^@ http://purl.uniprot.org/uniprot/P71590 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand ^@ Abolishes phosphorylation by PknB.|||Abolishes phosphorylation by PknB. Strong decrease in affinity for MviN.|||Basic and acidic residues|||Decrease in affinity for MviN.|||Does not affect affinity for MviN.|||FHA|||FHA domain-containing protein FhaA|||Lack of phosphorylation.|||Phosphothreonine|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000419664 http://togogenome.org/gene/83332:Rv2949c ^@ http://purl.uniprot.org/uniprot/P9WIC5 ^@ Molecule Processing ^@ Chain ^@ Chorismate pyruvate-lyase ^@ http://purl.uniprot.org/annotation/PRO_0000240510 http://togogenome.org/gene/83332:Rv0198c ^@ http://purl.uniprot.org/uniprot/I6X8R2 ^@ Region ^@ Domain Extent ^@ Peptidase_M13|||Peptidase_M13_N ^@ http://togogenome.org/gene/83332:Rv3293 ^@ http://purl.uniprot.org/uniprot/L7N650 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Aldedh ^@ http://togogenome.org/gene/83332:Rv1026 ^@ http://purl.uniprot.org/uniprot/P96374 ^@ Molecule Processing ^@ Chain ^@ Exopolyphosphatase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000440100 http://togogenome.org/gene/83332:Rv2781c ^@ http://purl.uniprot.org/uniprot/I6X5C5 ^@ Region ^@ Domain Extent ^@ NMO ^@ http://togogenome.org/gene/83332:Rv0515 ^@ http://purl.uniprot.org/uniprot/O33360 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ HNHc|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1691 ^@ http://purl.uniprot.org/uniprot/O33193 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv1523 ^@ http://purl.uniprot.org/uniprot/Q50584 ^@ Region ^@ Domain Extent ^@ Methyltransf_11 ^@ http://togogenome.org/gene/83332:Rv2359 ^@ http://purl.uniprot.org/uniprot/P9WN85 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Zinc uptake regulation protein ^@ http://purl.uniprot.org/annotation/PRO_0000419204 http://togogenome.org/gene/83332:Rv2003c ^@ http://purl.uniprot.org/uniprot/P9WJZ5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2003c ^@ http://purl.uniprot.org/annotation/PRO_0000103930 http://togogenome.org/gene/83332:Rv3177 ^@ http://purl.uniprot.org/uniprot/O53327 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv1827 ^@ http://purl.uniprot.org/uniprot/P9WJA9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Decreases ability to bind to and regulate the activities of Gdh and GltB, but does not affect ability to inhibit Kgd.|||Does not affect phosphorylation by PknG.|||FHA|||Glycogen accumulation regulator GarA|||Lack of phosphorylation by PknG.|||N-acetylthreonine|||Phosphothreonine; by PknB|||Phosphothreonine; by PknG|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000103902 http://togogenome.org/gene/83332:Rv2184c ^@ http://purl.uniprot.org/uniprot/O53518 ^@ Molecule Processing ^@ Chain ^@ Protein Rv2184c ^@ http://purl.uniprot.org/annotation/PRO_0000456388 http://togogenome.org/gene/83332:Rv2148c ^@ http://purl.uniprot.org/uniprot/P9WFQ7 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Pyridoxal phosphate homeostasis protein ^@ http://purl.uniprot.org/annotation/PRO_0000163203 http://togogenome.org/gene/83332:Rv1639c ^@ http://purl.uniprot.org/uniprot/P94973 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3862c ^@ http://purl.uniprot.org/uniprot/P9WF37 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mass ^@ 4Fe-4S Wbl-type|||Fully oxidized recombinant protein tagged at both termini.|||Fully reduced recombinant protein tagged at both termini.|||Probable transcriptional regulator WhiB6 ^@ http://purl.uniprot.org/annotation/PRO_0000420386 http://togogenome.org/gene/83332:Rv0734 ^@ http://purl.uniprot.org/uniprot/P9WK21 ^@ Experimental Information|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Mass ^@ Methionine aminopeptidase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000414588 http://togogenome.org/gene/83332:Rv3695 ^@ http://purl.uniprot.org/uniprot/O69663 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Helical|||Pro residues|||RDD ^@ http://togogenome.org/gene/83332:Rv0549c ^@ http://purl.uniprot.org/uniprot/P9WFB7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC3 ^@ http://purl.uniprot.org/annotation/PRO_0000407866 http://togogenome.org/gene/83332:Rv3345c ^@ http://purl.uniprot.org/uniprot/Q6MWY0 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1041c ^@ http://purl.uniprot.org/uniprot/P96360 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||DDE_Tnp_1 ^@ http://togogenome.org/gene/83332:Rv0688 ^@ http://purl.uniprot.org/uniprot/P95034 ^@ Region ^@ Domain Extent ^@ Pyr_redox_2|||Reductase_C ^@ http://togogenome.org/gene/83332:Rv0865 ^@ http://purl.uniprot.org/uniprot/I6Y8Y8 ^@ Region ^@ Domain Extent ^@ MoCF_biosynth ^@ http://togogenome.org/gene/83332:Rv2045c ^@ http://purl.uniprot.org/uniprot/O53488 ^@ Region ^@ Domain Extent ^@ COesterase ^@ http://togogenome.org/gene/83332:Rv1008 ^@ http://purl.uniprot.org/uniprot/O08343 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized metal-dependent hydrolase TatD ^@ http://purl.uniprot.org/annotation/PRO_0000434887 http://togogenome.org/gene/83332:Rv2634c ^@ http://purl.uniprot.org/uniprot/P9WIE7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues|||Uncharacterized PE-PGRS family protein PE_PGRS46 ^@ http://purl.uniprot.org/annotation/PRO_0000216171 http://togogenome.org/gene/83332:Rv1849 ^@ http://purl.uniprot.org/uniprot/P9WFE9 ^@ Molecule Processing ^@ Chain ^@ Urease subunit beta ^@ http://purl.uniprot.org/annotation/PRO_0000067579 http://togogenome.org/gene/83332:Rv1337 ^@ http://purl.uniprot.org/uniprot/E2IBS4|||http://purl.uniprot.org/uniprot/P9WM21 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||Rhomboid|||Uncharacterized protein Rv1337 ^@ http://purl.uniprot.org/annotation/PRO_0000103811 http://togogenome.org/gene/83332:Rv0809 ^@ http://purl.uniprot.org/uniprot/I6Y4V6 ^@ Region ^@ Domain Extent ^@ AIRS|||AIRS_C ^@ http://togogenome.org/gene/83332:Rv1121 ^@ http://purl.uniprot.org/uniprot/P9WN71 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Glucose-6-phosphate 1-dehydrogenase 1|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000068128 http://togogenome.org/gene/83332:Rv1661 ^@ http://purl.uniprot.org/uniprot/P94996 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv0301 ^@ http://purl.uniprot.org/uniprot/P9WFB9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ PINc|||Ribonuclease VapC2 ^@ http://purl.uniprot.org/annotation/PRO_0000407865 http://togogenome.org/gene/83332:Rv0636 ^@ http://purl.uniprot.org/uniprot/I6WYY7 ^@ Region ^@ Domain Extent ^@ MaoC-like ^@ http://togogenome.org/gene/83332:Rv2843 ^@ http://purl.uniprot.org/uniprot/I6YAE2 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5003706965 http://togogenome.org/gene/83332:Rv3376 ^@ http://purl.uniprot.org/uniprot/P9WMS5 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Nucleophile|||Phosphatase Rv3376 ^@ http://purl.uniprot.org/annotation/PRO_0000416458 http://togogenome.org/gene/83332:Rv1483 ^@ http://purl.uniprot.org/uniprot/P9WGT3 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Mass|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 3-oxoacyl-[acyl-carrier-protein] reductase MabA|||70% decrease in activity with acetoacetyl-CoA as substrate. Does not affect NADP binding.|||Complete protein inactivation and freezes the catalytic site into its closed form. Totally inactive; when associated with V-60 and L-144.|||Displays a lower activity than the wild-type and a slightly decreased affinity for the cofactor. Retains 84% of activity; when associated with L-144. Totally inactive; when associated with A-139 and L-144.|||Loss of activity. Can still bind NADPH.|||Loss of activity. Impaired NADPH binding.|||N-acetylthreonine|||Phosphomimetic mutant that retains less than 10% of wild-type reductase activity. Impaired NADPH binding. Overproduction of the mutant leads to a significant inhibition of de novo biosynthesis of mycolic acids.|||Phosphothreonine|||Proton acceptor|||Recombinant protein expressed in E.coli.|||Removed|||Retains 22% of wild-type reductase activity. Strong decrease in phosphorylation by PknB. Lack of phosphorylation by PknB; when associated with A-21 and A-114.|||Slight decrease in phosphorylation by PknB. Lack of phosphorylation by PknB; when associated with A-114 and A-191.|||Slight decrease in phosphorylation by PknB. Lack of phosphorylation by PknB; when associated with A-21 and A-191.|||Stabilizes the catalytic loop in its open active form. Retains 84% of activity; when associated with V-60. Totally inactive; when associated with V-60 and A-139. ^@ http://purl.uniprot.org/annotation/PRO_0000054677 http://togogenome.org/gene/83332:Rv3009c ^@ http://purl.uniprot.org/uniprot/P9WN61 ^@ Molecule Processing ^@ Chain ^@ Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B ^@ http://purl.uniprot.org/annotation/PRO_0000148814 http://togogenome.org/gene/83332:Rv1140 ^@ http://purl.uniprot.org/uniprot/O06540 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2672 ^@ http://purl.uniprot.org/uniprot/P71969 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Abhydrolase_4 ^@ http://purl.uniprot.org/annotation/PRO_5004161241 http://togogenome.org/gene/83332:Rv3566c ^@ http://purl.uniprot.org/uniprot/P9WJI5 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-thioester intermediate|||Arylamine N-acetyltransferase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000107919 http://togogenome.org/gene/83332:Rv1308 ^@ http://purl.uniprot.org/uniprot/P9WPU7 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink ^@ ATP synthase subunit alpha|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000144339 http://togogenome.org/gene/83332:Rv2274A ^@ http://purl.uniprot.org/uniprot/P0CL60 ^@ Molecule Processing ^@ Chain ^@ Antitoxin MazE8 ^@ http://purl.uniprot.org/annotation/PRO_0000406302 http://togogenome.org/gene/83332:Rv0030 ^@ http://purl.uniprot.org/uniprot/P9WM95 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0030 ^@ http://purl.uniprot.org/annotation/PRO_0000103648 http://togogenome.org/gene/83332:Rv1781c ^@ http://purl.uniprot.org/uniprot/P9WK23 ^@ Molecule Processing ^@ Chain ^@ 4-alpha-glucanotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000170127 http://togogenome.org/gene/83332:Rv3501c ^@ http://purl.uniprot.org/uniprot/O53546 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2959c ^@ http://purl.uniprot.org/uniprot/P9WIM5 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Rhamnosyl O-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000305181 http://togogenome.org/gene/83332:Rv0208c ^@ http://purl.uniprot.org/uniprot/P9WFY9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region ^@ Polar residues|||tRNA (guanine-N(7)-)-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000171361 http://togogenome.org/gene/83332:Rv3834c ^@ http://purl.uniprot.org/uniprot/P9WFT7 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue ^@ N6-acetyllysine|||Serine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000122086 http://togogenome.org/gene/83332:Rv2791c ^@ http://purl.uniprot.org/uniprot/O33333 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||HTH_OrfB_IS605|||OrfB_IS605|||OrfB_Zn_ribbon ^@ http://togogenome.org/gene/83332:Rv3315c ^@ http://purl.uniprot.org/uniprot/P9WPH3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Mass|||Strand|||Turn ^@ CMP/dCMP-type deaminase|||Cytidine deaminase|||Proton donor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000420699 http://togogenome.org/gene/83332:Rv3656c ^@ http://purl.uniprot.org/uniprot/O69624 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ DUF4244 domain-containing protein|||Helical ^@ http://purl.uniprot.org/annotation/PRO_5010342988 http://togogenome.org/gene/83332:Rv0036c ^@ http://purl.uniprot.org/uniprot/P9WM91 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0036c ^@ http://purl.uniprot.org/annotation/PRO_0000103652 http://togogenome.org/gene/83332:Rv3279c ^@ http://purl.uniprot.org/uniprot/I6YFP0 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ BPL/LPL catalytic|||Biotin--[acetyl-CoA-carboxylase] ligase|||Loss of activity. ^@ http://purl.uniprot.org/annotation/PRO_0000452501 http://togogenome.org/gene/83332:Rv0529 ^@ http://purl.uniprot.org/uniprot/O06393 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Cytochrom_C_asm|||Helical ^@ http://togogenome.org/gene/83332:Rv0001 ^@ http://purl.uniprot.org/uniprot/P9WNW3 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Sequence Conflict ^@ Chromosomal replication initiator protein DnaA|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000114218 http://togogenome.org/gene/83332:Rv1701 ^@ http://purl.uniprot.org/uniprot/P9WF33 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Core-binding (CB)|||O-(3'-phospho-DNA)-tyrosine intermediate|||Tyr recombinase|||Tyrosine recombinase XerD ^@ http://purl.uniprot.org/annotation/PRO_0000095398 http://togogenome.org/gene/83332:Rv3466 ^@ http://purl.uniprot.org/uniprot/P9WKY1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic residues|||Uncharacterized protein Rv3466 ^@ http://purl.uniprot.org/annotation/PRO_0000104137 http://togogenome.org/gene/83332:Rv0332 ^@ http://purl.uniprot.org/uniprot/O07256 ^@ Region ^@ Domain Extent ^@ MDMPI_C|||MDMPI_N ^@ http://togogenome.org/gene/83332:Rv0820 ^@ http://purl.uniprot.org/uniprot/P9WQL1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Phosphate import ATP-binding protein PstB 1 ^@ http://purl.uniprot.org/annotation/PRO_0000092849 http://togogenome.org/gene/83332:Rv2372c ^@ http://purl.uniprot.org/uniprot/P9WGX1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Ribosomal RNA small subunit methyltransferase E ^@ http://purl.uniprot.org/annotation/PRO_0000176213 http://togogenome.org/gene/83332:Rv2856 ^@ http://purl.uniprot.org/uniprot/I6YEJ7 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0647c ^@ http://purl.uniprot.org/uniprot/P9WQI1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0647c ^@ http://purl.uniprot.org/annotation/PRO_0000200735 http://togogenome.org/gene/83332:Rv1837c ^@ http://purl.uniprot.org/uniprot/P9WK17 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Cysteine sulfenic acid (-SOH)|||Malate synthase G|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000166889 http://togogenome.org/gene/83332:Rv2194 ^@ http://purl.uniprot.org/uniprot/P9WP35 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Transmembrane|||Turn ^@ Cytochrome bc1 complex cytochrome c subunit|||Cytochrome c 1|||Cytochrome c 2|||Helical|||axial binding residue|||covalent ^@ http://purl.uniprot.org/annotation/PRO_0000108450 http://togogenome.org/gene/83332:Rv2684 ^@ http://purl.uniprot.org/uniprot/P9WPD9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized transporter Rv2684 ^@ http://purl.uniprot.org/annotation/PRO_0000172514 http://togogenome.org/gene/83332:Rv3874 ^@ http://purl.uniprot.org/uniprot/P9WNK5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Coiled-Coil|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Turn ^@ Abolishes EsxB-EsxA heterodimer interaction with EccCb1 and EspA, maintains interaction with EccA2 and EccE2.|||Abolishes EsxB-EsxA heterodimer interaction with EccCb1, maintains interaction with EspA, EccA2 and EccE2.|||Abolishes EsxB-EsxA heterodimer interaction with EccCb1, weaker interaction with EspA, maintains interaction with EccA2 and EccE2.|||Abolishes interaction with EccCb1, but not with EsxA.|||Abolishes interaction with EccCb1, but not with EsxA. No change in stability, but loss of secretion.|||ESAT-6-like protein EsxB|||N-acetylalanine|||No change in stability.|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000167796 http://togogenome.org/gene/83332:Rv1650 ^@ http://purl.uniprot.org/uniprot/P9WFU1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ B5|||FDX-ACB|||Phenylalanine--tRNA ligase beta subunit|||tRNA-binding ^@ http://purl.uniprot.org/annotation/PRO_0000126916 http://togogenome.org/gene/83332:Rv2493 ^@ http://purl.uniprot.org/uniprot/P9WJ25 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB38 ^@ http://purl.uniprot.org/annotation/PRO_0000408080 http://togogenome.org/gene/83332:Rv3705c ^@ http://purl.uniprot.org/uniprot/I6XI06 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Disulfide Bond|||Domain Extent|||Signal Peptide ^@ PknH_C ^@ http://purl.uniprot.org/annotation/PRO_5010342983 http://togogenome.org/gene/83332:Rv0560c ^@ http://purl.uniprot.org/uniprot/P9WKL5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase|||6.7-fold increase in catalytic efficiency with componud 14 as substrate. ^@ http://purl.uniprot.org/annotation/PRO_0000419777 http://togogenome.org/gene/83332:Rv3429 ^@ http://purl.uniprot.org/uniprot/P9WHY1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE59 ^@ http://purl.uniprot.org/annotation/PRO_0000217855 http://togogenome.org/gene/83332:Rv2310 ^@ http://purl.uniprot.org/uniprot/P9WLC3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2310 ^@ http://purl.uniprot.org/annotation/PRO_0000104018 http://togogenome.org/gene/83332:Rv2801c ^@ http://purl.uniprot.org/uniprot/P71650 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Endoribonuclease MazF9 ^@ http://purl.uniprot.org/annotation/PRO_0000406309 http://togogenome.org/gene/83332:Rv0046c ^@ http://purl.uniprot.org/uniprot/P9WKI1 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Inositol-3-phosphate synthase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylserine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000195203 http://togogenome.org/gene/83332:Rv1238 ^@ http://purl.uniprot.org/uniprot/P9WQI3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Trehalose import ATP-binding protein SugC ^@ http://purl.uniprot.org/annotation/PRO_0000419314 http://togogenome.org/gene/83332:Rv2458 ^@ http://purl.uniprot.org/uniprot/O53185 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Hcy-binding ^@ http://togogenome.org/gene/83332:Rv3824c ^@ http://purl.uniprot.org/uniprot/P9WIK9 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase PapA1|||Loss of sulfolipid-1 (SL-1) production. ^@ http://purl.uniprot.org/annotation/PRO_0000314658 http://togogenome.org/gene/83332:Rv0352 ^@ http://purl.uniprot.org/uniprot/P9WNV9 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Repeat|||Sequence Conflict|||Zinc Finger ^@ CR-type|||CXXCXGXG motif|||Chaperone protein DnaJ 1|||J ^@ http://purl.uniprot.org/annotation/PRO_0000070835 http://togogenome.org/gene/83332:Rv1894c ^@ http://purl.uniprot.org/uniprot/O07738 ^@ Region ^@ Domain Extent ^@ NMO ^@ http://togogenome.org/gene/83332:Rv1533 ^@ http://purl.uniprot.org/uniprot/O06179 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative monooxygenase Rv1533 ^@ http://purl.uniprot.org/annotation/PRO_0000393572 http://togogenome.org/gene/83332:Rv2715 ^@ http://purl.uniprot.org/uniprot/P9WNH3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Uncharacterized protein Rv2715 ^@ http://purl.uniprot.org/annotation/PRO_0000207084 http://togogenome.org/gene/83332:Rv1859 ^@ http://purl.uniprot.org/uniprot/P9WQL3 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Sequence Conflict ^@ ABC transporter|||Molybdenum import ATP-binding protein ModC|||Mop ^@ http://purl.uniprot.org/annotation/PRO_0000092565 http://togogenome.org/gene/83332:Rv1348 ^@ http://purl.uniprot.org/uniprot/P9WQJ9 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ ABC transmembrane type-1|||ABC transporter|||Cytoplasmic|||Decrease in FAD-binding and loss of activity.|||FAD-binding FR-type|||Helical|||Mycobactin import ATP-binding/permease protein IrtA|||No change in FAD-binding and in activity.|||Periplasmic ^@ http://purl.uniprot.org/annotation/PRO_0000093255 http://togogenome.org/gene/83332:Rv1673c ^@ http://purl.uniprot.org/uniprot/O53920 ^@ Region ^@ Domain Extent ^@ TGc ^@ http://togogenome.org/gene/83332:Rv3390 ^@ http://purl.uniprot.org/uniprot/O50416 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5030174824 http://togogenome.org/gene/83332:Rv0313 ^@ http://purl.uniprot.org/uniprot/P9WL03 ^@ Molecule Processing ^@ Chain|||Initiator Methionine ^@ Removed|||Uncharacterized protein Rv0313 ^@ http://purl.uniprot.org/annotation/PRO_0000403671 http://togogenome.org/gene/83332:Rv1186c ^@ http://purl.uniprot.org/uniprot/O50442 ^@ Region ^@ Domain Extent ^@ HTH_30 ^@ http://togogenome.org/gene/83332:Rv1494 ^@ http://purl.uniprot.org/uniprot/P9WJ91 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Probable antitoxin MazE4 ^@ http://purl.uniprot.org/annotation/PRO_0000103858 http://togogenome.org/gene/83332:Rv1151c ^@ http://purl.uniprot.org/uniprot/P9WGG3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ Deacetylase sirtuin-type|||NAD-dependent protein deacylase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000110331 http://togogenome.org/gene/83332:Rv3650 ^@ http://purl.uniprot.org/uniprot/I6X7Z8 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv2340c ^@ http://purl.uniprot.org/uniprot/L7N659 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0570 ^@ http://purl.uniprot.org/uniprot/P9WH77 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond|||Domain Extent ^@ ATP-cone|||Cysteine radical intermediate|||Proton acceptor|||Redox-active|||Vitamin B12-dependent ribonucleoside-diphosphate reductase ^@ http://purl.uniprot.org/annotation/PRO_0000392684 http://togogenome.org/gene/83332:Rv1804c ^@ http://purl.uniprot.org/uniprot/O53953 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ DUF732 ^@ http://purl.uniprot.org/annotation/PRO_5010172042 http://togogenome.org/gene/83332:Rv2969c ^@ http://purl.uniprot.org/uniprot/O33272 ^@ Modification|||Region ^@ Disulfide Bond|||Domain Extent|||Transmembrane ^@ Helical|||Thioredoxin-like_fold ^@ http://togogenome.org/gene/83332:Rv0219 ^@ http://purl.uniprot.org/uniprot/P96401 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0708 ^@ http://purl.uniprot.org/uniprot/P9WHD5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 50S ribosomal protein L16|||Basic residues ^@ http://purl.uniprot.org/annotation/PRO_0000062138 http://togogenome.org/gene/83332:Rv3844 ^@ http://purl.uniprot.org/uniprot/P96234 ^@ Region ^@ Domain Extent ^@ DEDD_Tnp_IS110 ^@ http://togogenome.org/gene/83332:Rv2471 ^@ http://purl.uniprot.org/uniprot/O53198 ^@ Region ^@ Domain Extent ^@ Aamy ^@ http://togogenome.org/gene/83332:Rv3329 ^@ http://purl.uniprot.org/uniprot/O53379 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Probable aminotransferase Rv3329 ^@ http://purl.uniprot.org/annotation/PRO_0000432513 http://togogenome.org/gene/83332:Rv3667 ^@ http://purl.uniprot.org/uniprot/P9WQD1 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue|||Mutagenesis Site ^@ Acetyl-coenzyme A synthetase|||Complete loss of acetyl-coenzyme A synthetase activity.|||N-acetylserine|||N6-acetyllysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000208369 http://togogenome.org/gene/83332:Rv0541c ^@ http://purl.uniprot.org/uniprot/O06407 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3482c ^@ http://purl.uniprot.org/uniprot/I6YG92 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Basic and acidic residues|||DUF2510|||Helical ^@ http://togogenome.org/gene/83332:Rv1373 ^@ http://purl.uniprot.org/uniprot/P9WGB9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Glycolipid sulfotransferase Rv1373|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000315390 http://togogenome.org/gene/83332:Rv0343 ^@ http://purl.uniprot.org/uniprot/P9WJ95 ^@ Molecule Processing ^@ Chain ^@ Isoniazid-induced protein IniC ^@ http://purl.uniprot.org/annotation/PRO_0000390793 http://togogenome.org/gene/83332:Rv0835 ^@ http://purl.uniprot.org/uniprot/O53846 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PknH_C ^@ http://purl.uniprot.org/annotation/PRO_5010241335 http://togogenome.org/gene/83332:Rv1209 ^@ http://purl.uniprot.org/uniprot/O05310 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2382c ^@ http://purl.uniprot.org/uniprot/P71718 ^@ Region ^@ Domain Extent ^@ Ketosynthase (KS) ^@ http://togogenome.org/gene/83332:Rv0170 ^@ http://purl.uniprot.org/uniprot/O07414 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv1013 ^@ http://purl.uniprot.org/uniprot/O05598 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Putative ligase Rv1013 ^@ http://purl.uniprot.org/annotation/PRO_0000395881 http://togogenome.org/gene/83332:Rv0658c ^@ http://purl.uniprot.org/uniprot/O06781 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2204c ^@ http://purl.uniprot.org/uniprot/P9WMN5 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Protein Rv2204c|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000077019 http://togogenome.org/gene/83332:Rv3610c ^@ http://purl.uniprot.org/uniprot/P9WQN3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Topological Domain|||Transmembrane ^@ ATP-dependent zinc metalloprotease FtsH|||Cytoplasmic|||Extracellular|||Helical|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000084644 http://togogenome.org/gene/83332:Rv0916c ^@ http://purl.uniprot.org/uniprot/I6Y936 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv1318c ^@ http://purl.uniprot.org/uniprot/P9WQ33 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Guanylate cyclase|||HAMP|||Helical|||Uncharacterized protein Rv1318c ^@ http://purl.uniprot.org/annotation/PRO_0000195752 http://togogenome.org/gene/83332:Rv3014c ^@ http://purl.uniprot.org/uniprot/P9WNV1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ BRCT|||DNA ligase A|||N6-AMP-lysine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000161752 http://togogenome.org/gene/83332:Rv2503c ^@ http://purl.uniprot.org/uniprot/P9WPW3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit B ^@ http://purl.uniprot.org/annotation/PRO_0000157923 http://togogenome.org/gene/83332:Rv3803c ^@ http://purl.uniprot.org/uniprot/P9WQN7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Sequence Conflict|||Signal Peptide|||Strand|||Turn ^@ MPT51/MPB51 antigen ^@ http://purl.uniprot.org/annotation/PRO_0000000230 http://togogenome.org/gene/83332:Rv2979c ^@ http://purl.uniprot.org/uniprot/I6XFU1 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ O-(5'-phospho-DNA)-serine intermediate|||Resolvase/invertase-type recombinase catalytic ^@ http://togogenome.org/gene/83332:Rv0229c ^@ http://purl.uniprot.org/uniprot/L0T5V6 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC51 ^@ http://purl.uniprot.org/annotation/PRO_0000430096 http://togogenome.org/gene/83332:Rv3356c ^@ http://purl.uniprot.org/uniprot/P9WG81 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Bifunctional protein FolD ^@ http://purl.uniprot.org/annotation/PRO_0000268404 http://togogenome.org/gene/83332:Rv2323c ^@ http://purl.uniprot.org/uniprot/P71889 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ N(G),N(G)-dimethylarginine dimethylaminohydrolase|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000443949 http://togogenome.org/gene/83332:Rv3163c ^@ http://purl.uniprot.org/uniprot/O53313 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic residues|||DUF58 ^@ http://togogenome.org/gene/83332:Rv2813 ^@ http://purl.uniprot.org/uniprot/I6XFD1 ^@ Region ^@ Domain Extent ^@ AAA ^@ http://togogenome.org/gene/83332:Rv0058 ^@ http://purl.uniprot.org/uniprot/P9WMR3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix ^@ DOD-type homing endonuclease|||Endonuclease PI-MtuHIP|||Replicative DNA helicase, 1st part|||Replicative DNA helicase, 2nd part|||SF4 helicase; first part|||SF4 helicase; second part ^@ http://purl.uniprot.org/annotation/PRO_0000013282|||http://purl.uniprot.org/annotation/PRO_0000013283|||http://purl.uniprot.org/annotation/PRO_0000013284 http://togogenome.org/gene/83332:Rv1249c ^@ http://purl.uniprot.org/uniprot/O50464 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2983 ^@ http://purl.uniprot.org/uniprot/P9WP83 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Phosphoenolpyruvate guanylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000398696 http://togogenome.org/gene/83332:Rv1713 ^@ http://purl.uniprot.org/uniprot/P9WNL3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ EngA-type G 1|||EngA-type G 2|||GTPase Der|||KH-like ^@ http://purl.uniprot.org/annotation/PRO_0000179017 http://togogenome.org/gene/83332:Rv0456B ^@ http://purl.uniprot.org/uniprot/P0CL57 ^@ Molecule Processing ^@ Chain ^@ Probable antitoxin MazE1 ^@ http://purl.uniprot.org/annotation/PRO_0000406295 http://togogenome.org/gene/83332:Rv0357c ^@ http://purl.uniprot.org/uniprot/P9WHN3 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ Adenylosuccinate synthetase|||N-acetylproline|||Proton acceptor|||Proton donor|||Removed|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000095199 http://togogenome.org/gene/83332:Rv1904 ^@ http://purl.uniprot.org/uniprot/O07728 ^@ Region ^@ Domain Extent ^@ STAS ^@ http://togogenome.org/gene/83332:Rv1543 ^@ http://purl.uniprot.org/uniprot/P9WGS1 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv1543 ^@ http://purl.uniprot.org/annotation/PRO_0000054856 http://togogenome.org/gene/83332:Rv0006 ^@ http://purl.uniprot.org/uniprot/P9WG47 ^@ Experimental Information|||Modification|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Motif|||Mutagenesis Site|||Sequence Conflict|||Sequence Variant|||Strand|||Turn ^@ 17-fold increased resistance to fluoroquinolones, 4- to 8-fold reduction in fluoroquinolone-induced DNA cleavage.|||25- 45-fold increased resistance to fluoroquinolones, 4- to 8-fold reduction in fluoroquinolone-induced DNA cleavage. Supercoiling, relaxation, decatenation activities no longer inhibited by MfpA.|||4- to 16-fold more efficient in fluoroquinolone-induced DNA cleavage alone. Hypersusceptibile, 2- to 14-fold higher sensitivity to fluoroquinolones, 2- to 8-fold more efficient in fluoroquinolone-induced DNA cleavage; when associated with A-80.|||80-fold increased resistance to fluoroquinolones, 32- to 64-fold reduction in fluoroquinolone-induced DNA cleavage.|||Confers ciprofloxacin resistance, in clinical isolate.|||Confers fluoroquinolone resistance, IC(50) is 2- to 26-fold higher than wild-type.|||Confers fluoroquinolone resistance, IC(50) is 3- to 43-fold higher than wild-type, in strains H37Ra and H37Rv.|||Confers ofloxacin resistance.|||DNA gyrase subunit A|||EF-hand|||GyrA-box|||GyrA-box-1|||Increased susceptibility to fluoroquinolones (makes sequence more like E.coli), supercoiling, relaxation, decatenation activities still inhibited by MfpA.|||N-acetylthreonine|||No change in supercoiling activity, wild-type decatenation or fluoroquinolone-induced DNA cleavage.|||No supercoiling activity, almost wild-type decatenation activity, wild-type fluoroquinolone-induced DNA cleavage.|||No supercoiling activity, wild-type decatenation and fluoroquinolone-induced DNA cleavage.|||No supercoiling or decatenation activity, decreased fluoroquinolone-induced DNA cleavage.|||O-(5'-phospho-DNA)-tyrosine intermediate|||Reduced supercoiling activity, wild-type decatenation and fluoroquinolone-induced DNA cleavage.|||Removed|||Significant reduction in DNA wrapping and supercoiling activity, no change in decatanation or relaxation activities.|||Slight reduction in supercoiling activity.|||Slight resistance to fluoroquinolones. Hypersusceptibile, 2- to 14-fold higher sensitivity to fluoroquinolones, 2- to 8-fold more efficient in fluoroquinolone-induced DNA cleavage; when associated with G-90.|||Wild-type decatenase activity (changes residue to match E.coli).|||Wild-type decatenase activity (changes residues to match E.coli).|||Wild-type supercoiling, decatenation and fluoroquinolone-induced DNA cleavage. ^@ http://purl.uniprot.org/annotation/PRO_0000145243 http://togogenome.org/gene/83332:Rv2725c ^@ http://purl.uniprot.org/uniprot/O33230 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Hflx-type G ^@ http://togogenome.org/gene/83332:Rv0180c ^@ http://purl.uniprot.org/uniprot/O07424 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DUF3533|||Helical ^@ http://togogenome.org/gene/83332:Rv2394 ^@ http://purl.uniprot.org/uniprot/P71750 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010255820 http://togogenome.org/gene/83332:Rv1358 ^@ http://purl.uniprot.org/uniprot/Q11028 ^@ Region ^@ Domain Extent ^@ HTH luxR-type ^@ http://togogenome.org/gene/83332:Rv2214c ^@ http://purl.uniprot.org/uniprot/P9WGS3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ AB hydrolase-1|||Probable oxidoreductase EphD|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000054854 http://togogenome.org/gene/83332:Rv3401 ^@ http://purl.uniprot.org/uniprot/P9WN13 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton donor|||Uncharacterized glycosyl hydrolase Rv3401 ^@ http://purl.uniprot.org/annotation/PRO_0000108021 http://togogenome.org/gene/83332:Rv0324 ^@ http://purl.uniprot.org/uniprot/O08446 ^@ Region ^@ Domain Extent ^@ HTH arsR-type|||Rhodanese ^@ http://togogenome.org/gene/83332:Rv1198 ^@ http://purl.uniprot.org/uniprot/P9WNJ5 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxL ^@ http://purl.uniprot.org/annotation/PRO_0000167805 http://togogenome.org/gene/83332:Rv1322A ^@ http://purl.uniprot.org/uniprot/L7N6B1 ^@ Region ^@ Domain Extent ^@ VOC ^@ http://togogenome.org/gene/83332:Rv2022c ^@ http://purl.uniprot.org/uniprot/O53468 ^@ Molecule Processing ^@ Chain ^@ Putative toxin HigB2 ^@ http://purl.uniprot.org/annotation/PRO_0000432913 http://togogenome.org/gene/83332:Rv0979A ^@ http://purl.uniprot.org/uniprot/P9WH99 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 50S ribosomal protein L32|||Basic residues ^@ http://purl.uniprot.org/annotation/PRO_0000172373 http://togogenome.org/gene/83332:Rv0983 ^@ http://purl.uniprot.org/uniprot/O53896 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Charge relay system|||Cytoplasmic|||Helical|||Loss of protease activity. Shows neither autoproteolytic nor proteolytic activity against beta-casein.|||PDZ|||Periplasmic|||Polar residues|||Serine protease PepD ^@ http://purl.uniprot.org/annotation/PRO_0000450863 http://togogenome.org/gene/83332:Rv2165c ^@ http://purl.uniprot.org/uniprot/P9WJP1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribosomal RNA small subunit methyltransferase H ^@ http://purl.uniprot.org/annotation/PRO_0000108667 http://togogenome.org/gene/83332:Rv2335 ^@ http://purl.uniprot.org/uniprot/P95231 ^@ Molecule Processing ^@ Chain ^@ Serine acetyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000401135 http://togogenome.org/gene/83332:Rv1819c ^@ http://purl.uniprot.org/uniprot/P9WQI9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ ABC transmembrane type-1|||ABC transporter|||Helical|||Hydrophilic compounds import ATP-binding/permease protein BacA|||Loss of cobalamin transport. Shows background ATPase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000093265 http://togogenome.org/gene/83332:Rv1990c ^@ http://purl.uniprot.org/uniprot/P9WLP7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Turn ^@ Mycobacterial cidal antitoxin MbcA|||No longer neutralizes the toxic effect of MbcT. ^@ http://purl.uniprot.org/annotation/PRO_0000014116 http://togogenome.org/gene/83332:Rv2483c ^@ http://purl.uniprot.org/uniprot/I6YDI9 ^@ Region ^@ Domain Extent ^@ PlsC ^@ http://togogenome.org/gene/83332:Rv3341 ^@ http://purl.uniprot.org/uniprot/P9WJY9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ AB hydrolase-1|||Homoserine O-acetyltransferase|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000155731 http://togogenome.org/gene/83332:Rv3499c ^@ http://purl.uniprot.org/uniprot/I6YC99 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv0522 ^@ http://purl.uniprot.org/uniprot/L7N6B9 ^@ Region ^@ Domain Extent|||Transmembrane ^@ AA_permease|||Helical ^@ http://togogenome.org/gene/83332:Rv1383 ^@ http://purl.uniprot.org/uniprot/P9WPK5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Carbamoyl-phosphate synthase small chain|||Glutamine amidotransferase type-1|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000112296 http://togogenome.org/gene/83332:Rv3131 ^@ http://purl.uniprot.org/uniprot/P9WIZ7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine ^@ Putative NAD(P)H nitroreductase Rv3131|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000392943 http://togogenome.org/gene/83332:Rv0882 ^@ http://purl.uniprot.org/uniprot/P9WKQ9 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0882 ^@ http://purl.uniprot.org/annotation/PRO_0000014081 http://togogenome.org/gene/83332:Rv0017c ^@ http://purl.uniprot.org/uniprot/P9WN99 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Modified Residue|||Mutagenesis Site|||Transmembrane ^@ Can rescue the moenomycin sensitivity phenotype and the aberrant short-length phenotype of the deletion mutant.|||Can rescue the moenomycin sensitivity phenotype of the deletion mutant, but cannot rescue the aberrant short-length phenotype.|||Helical|||Peptidoglycan glycosyltransferase RodA|||Phosphothreonine ^@ http://purl.uniprot.org/annotation/PRO_0000062710 http://togogenome.org/gene/83332:Rv0846c ^@ http://purl.uniprot.org/uniprot/I6WZK7 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site|||Signal Peptide ^@ Lack of activity.|||Multicopper oxidase MmcO|||Plastocyanin-like|||Slight decrease in activity.|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000433098 http://togogenome.org/gene/83332:Rv1220c ^@ http://purl.uniprot.org/uniprot/P9WJZ7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand ^@ Probable O-methyltransferase Rv1220c|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000380105 http://togogenome.org/gene/83332:Rv1023 ^@ http://purl.uniprot.org/uniprot/P9WNL1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Enolase|||Proton acceptor|||Proton donor|||covalent; in inhibited form ^@ http://purl.uniprot.org/annotation/PRO_0000133932 http://togogenome.org/gene/83332:Rv0668 ^@ http://purl.uniprot.org/uniprot/P9WGY7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ DNA-directed RNA polymerase subunit beta' ^@ http://purl.uniprot.org/annotation/PRO_0000067765 http://togogenome.org/gene/83332:Rv1506c ^@ http://purl.uniprot.org/uniprot/P71785 ^@ Molecule Processing ^@ Chain ^@ Putative methyltransferase Rv1506c ^@ http://purl.uniprot.org/annotation/PRO_0000438346 http://togogenome.org/gene/83332:Rv3551 ^@ http://purl.uniprot.org/uniprot/P9WPW1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Cholesterol ring-cleaving hydrolase IpdA subunit ^@ http://purl.uniprot.org/annotation/PRO_0000157928 http://togogenome.org/gene/83332:Rv1329c ^@ http://purl.uniprot.org/uniprot/P9WMR5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ DEAH box|||Helicase ATP-binding|||Probable ATP-dependent helicase DinG homolog ^@ http://purl.uniprot.org/annotation/PRO_0000102003 http://togogenome.org/gene/83332:Rv3028c ^@ http://purl.uniprot.org/uniprot/P9WNG9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Electron transfer flavoprotein subunit alpha ^@ http://purl.uniprot.org/annotation/PRO_0000167853 http://togogenome.org/gene/83332:Rv3915 ^@ http://purl.uniprot.org/uniprot/L7N653 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ MurNAc-LAA|||N-acetylmuramoyl-L-alanine amidase CwlM ^@ http://purl.uniprot.org/annotation/PRO_0000434795 http://togogenome.org/gene/83332:Rv0240 ^@ http://purl.uniprot.org/uniprot/P9WF87 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC24 ^@ http://purl.uniprot.org/annotation/PRO_0000407883 http://togogenome.org/gene/83332:Rv3366 ^@ http://purl.uniprot.org/uniprot/O50394 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ SpoU_methylase ^@ http://togogenome.org/gene/83332:Rv2000 ^@ http://purl.uniprot.org/uniprot/P9WLN7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2000 ^@ http://purl.uniprot.org/annotation/PRO_0000103927 http://togogenome.org/gene/83332:Rv3173c ^@ http://purl.uniprot.org/uniprot/O53323 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0070c ^@ http://purl.uniprot.org/uniprot/P9WGI7 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Serine hydroxymethyltransferase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000113619 http://togogenome.org/gene/83332:Rv2994 ^@ http://purl.uniprot.org/uniprot/P9WJW7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized MFS-type transporter Rv2994 ^@ http://purl.uniprot.org/annotation/PRO_0000390686 http://togogenome.org/gene/83332:Rv3677c ^@ http://purl.uniprot.org/uniprot/I6XHY3 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv0902c ^@ http://purl.uniprot.org/uniprot/P9WGK7 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Modified Residue|||Strand|||Transmembrane ^@ HAMP|||Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Sensor-type histidine kinase PrrB ^@ http://purl.uniprot.org/annotation/PRO_0000074854 http://togogenome.org/gene/83332:Rv3849 ^@ http://purl.uniprot.org/uniprot/P9WJB7 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Affects protein stability. Decreases affinity for DNA and dimerization capacity.|||Affects protein stability. Decreases affinity for DNA. Does not affect dimerization.|||Decreases affinity for DNA. Does not affect dimerization.|||Does not affect DNA binding.|||H-T-H motif|||Moderate impact on protein stability. Does not affect DNA binding.|||Nucleoid-associated protein EspR ^@ http://purl.uniprot.org/annotation/PRO_0000393905 http://togogenome.org/gene/83332:Rv3492c ^@ http://purl.uniprot.org/uniprot/I6YGA5 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0723 ^@ http://purl.uniprot.org/uniprot/P9WHD7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 50S ribosomal protein L15|||Basic and acidic residues ^@ http://purl.uniprot.org/annotation/PRO_0000104755 http://togogenome.org/gene/83332:Rv2120c ^@ http://purl.uniprot.org/uniprot/O33255 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Rick_17kDa_Anti ^@ http://togogenome.org/gene/83332:Rv3296 ^@ http://purl.uniprot.org/uniprot/P96901 ^@ Region ^@ Domain Extent ^@ Helicase ATP-binding|||Helicase C-terminal ^@ http://togogenome.org/gene/83332:Rv0190 ^@ http://purl.uniprot.org/uniprot/O07434 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue|||Mutagenesis Site ^@ Copper-sensing transcriptional repressor RicR|||N-acetylthreonine|||Removed|||Unresponsive to copper.|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000433099 http://togogenome.org/gene/83332:Rv2224c ^@ http://purl.uniprot.org/uniprot/P9WHR3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Lipid Binding|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ AB hydrolase-1|||Cannot cleave GroEL2.|||Cannot complement the growth defect of the disruption mutant. Cannot cleave GroEL2. Is unable to hydrolyze azocasein.|||N-palmitoyl cysteine|||Nucleophile|||Proton donor|||S-diacylglycerol cysteine|||Serine protease Hip1|||Small decrease in activity with azocasein as substrate. Almost abolishes cleavage of GroEL2. ^@ http://purl.uniprot.org/annotation/PRO_0000027329 http://togogenome.org/gene/83332:Rv0334 ^@ http://purl.uniprot.org/uniprot/P9WH13 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Glucose-1-phosphate thymidylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000395347 http://togogenome.org/gene/83332:Rv1394c ^@ http://purl.uniprot.org/uniprot/P9WPN3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 132|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052287 http://togogenome.org/gene/83332:Rv2032 ^@ http://purl.uniprot.org/uniprot/P9WIZ9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative NAD(P)H nitroreductase acg ^@ http://purl.uniprot.org/annotation/PRO_0000392626 http://togogenome.org/gene/83332:Rv2524c ^@ http://purl.uniprot.org/uniprot/P95029 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||Ketosynthase (KS)|||Malonyl-CoA:ACP transacylase (MAT) ^@ http://togogenome.org/gene/83332:Rv2884 ^@ http://purl.uniprot.org/uniprot/I6X5M3 ^@ Region ^@ DNA Binding|||Domain Extent ^@ OmpR/PhoB-type ^@ http://togogenome.org/gene/83332:Rv1864c ^@ http://purl.uniprot.org/uniprot/P95151 ^@ Region ^@ Domain Extent ^@ MOSC ^@ http://togogenome.org/gene/83332:Rv0993 ^@ http://purl.uniprot.org/uniprot/O05576 ^@ Region ^@ Domain Extent ^@ NTP_transferase ^@ http://togogenome.org/gene/83332:Rv2702 ^@ http://purl.uniprot.org/uniprot/P9WIN1 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Sequence Conflict ^@ Polar residues|||Polyphosphate glucokinase ^@ http://purl.uniprot.org/annotation/PRO_0000058536 http://togogenome.org/gene/83332:Rv2346c ^@ http://purl.uniprot.org/uniprot/P9WNI7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ ESAT-6-like protein EsxO ^@ http://purl.uniprot.org/annotation/PRO_0000167814 http://togogenome.org/gene/83332:Rv1829 ^@ http://purl.uniprot.org/uniprot/P9WLR5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ BFN|||Uncharacterized protein Rv1829 ^@ http://purl.uniprot.org/annotation/PRO_0000103904 http://togogenome.org/gene/83332:Rv3541c ^@ http://purl.uniprot.org/uniprot/I6XHI0 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase beta subunit|||Loss of activity. Still forms heterotetramers.|||Retains 2-4% of activity. Still forms heterotetramers. ^@ http://purl.uniprot.org/annotation/PRO_0000452240 http://togogenome.org/gene/83332:Rv2528c ^@ http://purl.uniprot.org/uniprot/I6Y9K2 ^@ Region ^@ Domain Extent ^@ Mrr_N|||Mrr_cat ^@ http://togogenome.org/gene/83332:Rv2430c ^@ http://purl.uniprot.org/uniprot/Q79FE1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Turn ^@ Does not affect formation of the PE25/PPE41 dimer, but abolishes EspG5 binding to PE25/PPE41.|||Does not disrupt the interaction with EspG5.|||PPE family protein PPE41 ^@ http://purl.uniprot.org/annotation/PRO_0000435111 http://togogenome.org/gene/83332:Rv2495c ^@ http://purl.uniprot.org/uniprot/O06159 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Modified Residue|||Strand|||Turn ^@ Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex|||Lipoyl-binding|||N6-lipoyllysine|||Peripheral subunit-binding (PSBD) ^@ http://purl.uniprot.org/annotation/PRO_0000420520 http://togogenome.org/gene/83332:Rv1259 ^@ http://purl.uniprot.org/uniprot/P9WM53 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Type-5 uracil-DNA glycosylase ^@ http://purl.uniprot.org/annotation/PRO_0000103774 http://togogenome.org/gene/83332:Rv3539 ^@ http://purl.uniprot.org/uniprot/P9WHX5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ PE-PPE|||Polar residues|||Uncharacterized PPE family protein PPE63 ^@ http://purl.uniprot.org/annotation/PRO_0000379118 http://togogenome.org/gene/83332:Rv0634A ^@ http://purl.uniprot.org/uniprot/P9WKS5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0634A ^@ http://purl.uniprot.org/annotation/PRO_0000399398 http://togogenome.org/gene/83332:Rv2231B ^@ http://purl.uniprot.org/uniprot/P0CW31 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB16 ^@ http://purl.uniprot.org/annotation/PRO_0000408062 http://togogenome.org/gene/83332:Rv1926c ^@ http://purl.uniprot.org/uniprot/P9WIP1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Signal Peptide|||Strand|||Turn ^@ Immunogenic protein MPT63 ^@ http://purl.uniprot.org/annotation/PRO_0000021736 http://togogenome.org/gene/83332:Rv0027 ^@ http://purl.uniprot.org/uniprot/P9WM99 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0027 ^@ http://purl.uniprot.org/annotation/PRO_0000103644 http://togogenome.org/gene/83332:Rv3143 ^@ http://purl.uniprot.org/uniprot/P9WGL7 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ 4-aspartylphosphate|||Removed|||Response regulatory|||Uncharacterized response regulatory protein Rv3143 ^@ http://purl.uniprot.org/annotation/PRO_0000403682 http://togogenome.org/gene/83332:Rv0892 ^@ http://purl.uniprot.org/uniprot/P9WNG1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized monooxygenase Rv0892 ^@ http://purl.uniprot.org/annotation/PRO_0000186458 http://togogenome.org/gene/83332:Rv1230c ^@ http://purl.uniprot.org/uniprot/O86313 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||SLT_2 ^@ http://togogenome.org/gene/83332:Rv0679c ^@ http://purl.uniprot.org/uniprot/I6WZ30 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5003706594 http://togogenome.org/gene/83332:Rv0685 ^@ http://purl.uniprot.org/uniprot/P9WNN1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Elongation factor Tu|||tr-type G ^@ http://purl.uniprot.org/annotation/PRO_0000091353 http://togogenome.org/gene/83332:Rv1516c ^@ http://purl.uniprot.org/uniprot/P71795 ^@ Region ^@ Domain Extent ^@ Glyco_trans_2-like ^@ http://togogenome.org/gene/83332:Rv0512 ^@ http://purl.uniprot.org/uniprot/P9WMP5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Delta-aminolevulinic acid dehydratase|||Schiff-base intermediate with substrate ^@ http://purl.uniprot.org/annotation/PRO_0000140505 http://togogenome.org/gene/83332:Rv1688 ^@ http://purl.uniprot.org/uniprot/P9WJP7 ^@ Molecule Processing ^@ Chain ^@ Putative 3-methyladenine DNA glycosylase ^@ http://purl.uniprot.org/annotation/PRO_0000100094 http://togogenome.org/gene/83332:Rv1874 ^@ http://purl.uniprot.org/uniprot/O07755 ^@ Region ^@ Domain Extent ^@ EthD ^@ http://togogenome.org/gene/83332:Rv1339 ^@ http://purl.uniprot.org/uniprot/P9WGC1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1339 ^@ http://purl.uniprot.org/annotation/PRO_0000192688 http://togogenome.org/gene/83332:Rv3038c ^@ http://purl.uniprot.org/uniprot/I6YAZ1 ^@ Region ^@ Domain Extent ^@ Methyltransf_11 ^@ http://togogenome.org/gene/83332:Rv2187 ^@ http://purl.uniprot.org/uniprot/O53521 ^@ Molecule Processing ^@ Chain ^@ Long-chain-fatty-acid--CoA ligase FadD15 ^@ http://purl.uniprot.org/annotation/PRO_0000406784 http://togogenome.org/gene/83332:Rv1520 ^@ http://purl.uniprot.org/uniprot/P9WLV5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1520 ^@ http://purl.uniprot.org/annotation/PRO_0000103868 http://togogenome.org/gene/83332:Rv2011c ^@ http://purl.uniprot.org/uniprot/P9WLM5 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2011c ^@ http://purl.uniprot.org/annotation/PRO_0000014118 http://togogenome.org/gene/83332:Rv0080 ^@ http://purl.uniprot.org/uniprot/P9WMA5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0080 ^@ http://purl.uniprot.org/annotation/PRO_0000392680 http://togogenome.org/gene/83332:Rv3720 ^@ http://purl.uniprot.org/uniprot/O69687 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable fatty acid methyltransferase Rv3720 ^@ http://purl.uniprot.org/annotation/PRO_0000432511 http://togogenome.org/gene/83332:Rv0912 ^@ http://purl.uniprot.org/uniprot/O05904 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2669 ^@ http://purl.uniprot.org/uniprot/P9WQG5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ N-acetyltransferase|||Uncharacterized N-acetyltransferase Rv2669 ^@ http://purl.uniprot.org/annotation/PRO_0000074628 http://togogenome.org/gene/83332:Rv3859c ^@ http://purl.uniprot.org/uniprot/P96218 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ For GATase activity|||Glutamate synthase [NADPH] large chain|||Glutamine amidotransferase type-2 ^@ http://purl.uniprot.org/annotation/PRO_0000419545 http://togogenome.org/gene/83332:Rv0377 ^@ http://purl.uniprot.org/uniprot/P9WMF7 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH lysR-type|||Uncharacterized HTH-type transcriptional regulator Rv0377 ^@ http://purl.uniprot.org/annotation/PRO_0000105811 http://togogenome.org/gene/83332:Rv0733 ^@ http://purl.uniprot.org/uniprot/P9WKF5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Mass|||Strand|||Turn ^@ Adenylate kinase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000158806 http://togogenome.org/gene/83332:Rv3308 ^@ http://purl.uniprot.org/uniprot/O53360 ^@ Region ^@ Domain Extent ^@ PGM_PMM_I|||PGM_PMM_II|||PGM_PMM_III|||PGM_PMM_IV ^@ http://togogenome.org/gene/83332:Rv0556 ^@ http://purl.uniprot.org/uniprot/O06422 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3692 ^@ http://purl.uniprot.org/uniprot/I6YGX9 ^@ Region ^@ Domain Extent ^@ AAA_3|||AAA_lid_2 ^@ http://togogenome.org/gene/83332:Rv0200 ^@ http://purl.uniprot.org/uniprot/O53651 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1033c ^@ http://purl.uniprot.org/uniprot/L7N689 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Modified Residue ^@ 4-aspartylphosphate|||OmpR/PhoB-type|||Response regulatory|||Transcriptional regulatory protein TrcR ^@ http://purl.uniprot.org/annotation/PRO_0000451063 http://togogenome.org/gene/83332:Rv1479 ^@ http://purl.uniprot.org/uniprot/Q79FN7 ^@ Region ^@ Domain Extent ^@ AAA_3|||AAA_lid_2 ^@ http://togogenome.org/gene/83332:Rv3059 ^@ http://purl.uniprot.org/uniprot/P9WPM7 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylalanine|||Putative cytochrome P450 136|||Removed|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052295 http://togogenome.org/gene/83332:Rv0862c ^@ http://purl.uniprot.org/uniprot/O53874 ^@ Region ^@ Domain Extent ^@ Helicase_C_3 ^@ http://togogenome.org/gene/83332:Rv1698 ^@ http://purl.uniprot.org/uniprot/P9WJ83 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Copper transporter MctB ^@ http://purl.uniprot.org/annotation/PRO_0000014105 http://togogenome.org/gene/83332:Rv2042c ^@ http://purl.uniprot.org/uniprot/O53486 ^@ Region ^@ Domain Extent ^@ NTF2 ^@ http://togogenome.org/gene/83332:Rv2535c ^@ http://purl.uniprot.org/uniprot/I6YDN6 ^@ Region ^@ Domain Extent ^@ Creatinase_N|||Peptidase_M24 ^@ http://togogenome.org/gene/83332:Rv2895c ^@ http://purl.uniprot.org/uniprot/P9WL31 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ FAD-binding FR-type|||Uncharacterized protein Rv2895c ^@ http://purl.uniprot.org/annotation/PRO_0000104093 http://togogenome.org/gene/83332:Rv1005c ^@ http://purl.uniprot.org/uniprot/O05591 ^@ Region ^@ Domain Extent ^@ Chorismate_bind ^@ http://togogenome.org/gene/83332:Rv1530 ^@ http://purl.uniprot.org/uniprot/P9WQC3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable alcohol dehydrogenase adh ^@ http://purl.uniprot.org/annotation/PRO_0000391340 http://togogenome.org/gene/83332:Rv2361c ^@ http://purl.uniprot.org/uniprot/P9WFF7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Decaprenyl diphosphate synthase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000123641 http://togogenome.org/gene/83332:Rv2539c ^@ http://purl.uniprot.org/uniprot/P9WPY3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Shikimate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000192393 http://togogenome.org/gene/83332:Rv3188 ^@ http://purl.uniprot.org/uniprot/O53334 ^@ Molecule Processing ^@ Chain ^@ Probable mycobacterial cidal antitoxin Rv3188 ^@ http://purl.uniprot.org/annotation/PRO_0000448604 http://togogenome.org/gene/83332:Rv0433 ^@ http://purl.uniprot.org/uniprot/P9WPK9 ^@ Molecule Processing ^@ Chain ^@ Putative glutamate--cysteine ligase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000218208 http://togogenome.org/gene/83332:Rv2505c ^@ http://purl.uniprot.org/uniprot/I6Y0X0 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv1000c ^@ http://purl.uniprot.org/uniprot/L7N6A4 ^@ Region ^@ Domain Extent ^@ Fe2OG dioxygenase ^@ http://togogenome.org/gene/83332:Rv3006 ^@ http://purl.uniprot.org/uniprot/I6Y293 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ GSDH|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5003706845 http://togogenome.org/gene/83332:Rv3608c ^@ http://purl.uniprot.org/uniprot/P9WND1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Dihydropteroate synthase|||Pterin-binding ^@ http://purl.uniprot.org/annotation/PRO_0000168215 http://togogenome.org/gene/83332:Rv0746 ^@ http://purl.uniprot.org/uniprot/Q79FW8 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5004287726 http://togogenome.org/gene/83332:Rv2830c ^@ http://purl.uniprot.org/uniprot/P71622 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB22 ^@ http://purl.uniprot.org/annotation/PRO_0000408047 http://togogenome.org/gene/83332:Rv1936 ^@ http://purl.uniprot.org/uniprot/P95278 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv0039c ^@ http://purl.uniprot.org/uniprot/P9WM89 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0039c ^@ http://purl.uniprot.org/annotation/PRO_0000103656 http://togogenome.org/gene/83332:Rv3702c ^@ http://purl.uniprot.org/uniprot/O69670 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase|||Glutamine amidotransferase type-2|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000413650 http://togogenome.org/gene/83332:Rv3154 ^@ http://purl.uniprot.org/uniprot/P95172 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0383c ^@ http://purl.uniprot.org/uniprot/O53718 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv1560 ^@ http://purl.uniprot.org/uniprot/P9WLU3 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Antitoxin VapB11 ^@ http://purl.uniprot.org/annotation/PRO_0000103881 http://togogenome.org/gene/83332:Rv0695 ^@ http://purl.uniprot.org/uniprot/P9WP59 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Mycofactocin precursor peptide peptidase ^@ http://purl.uniprot.org/annotation/PRO_0000415279 http://togogenome.org/gene/83332:Rv0345 ^@ http://purl.uniprot.org/uniprot/O06296 ^@ Region ^@ Domain Extent ^@ NTP_transf_3 ^@ http://togogenome.org/gene/83332:Rv3240c ^@ http://purl.uniprot.org/uniprot/P9WGP5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Helix|||Strand|||Turn ^@ Basic and acidic residues|||Protein translocase subunit SecA 1 ^@ http://purl.uniprot.org/annotation/PRO_0000109598 http://togogenome.org/gene/83332:Rv1526c ^@ http://purl.uniprot.org/uniprot/P9WLV1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1526c ^@ http://purl.uniprot.org/annotation/PRO_0000103872 http://togogenome.org/gene/83332:Rv2052c ^@ http://purl.uniprot.org/uniprot/O53494 ^@ Region ^@ Domain Extent ^@ Amidohydro_3 ^@ http://togogenome.org/gene/83332:Rv0525 ^@ http://purl.uniprot.org/uniprot/O06391 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Uncharacterized protein Rv0525 ^@ http://purl.uniprot.org/annotation/PRO_0000396087 http://togogenome.org/gene/83332:Rv2229c ^@ http://purl.uniprot.org/uniprot/P9WLH3 ^@ Molecule Processing|||Region ^@ Chain|||Coiled-Coil ^@ Uncharacterized protein Rv2229c ^@ http://purl.uniprot.org/annotation/PRO_0000103983 http://togogenome.org/gene/83332:Rv1884c ^@ http://purl.uniprot.org/uniprot/O07747 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ Loss of resuscitating activity on M.luteus.|||Resuscitation-promoting factor RpfC ^@ http://purl.uniprot.org/annotation/PRO_0000421029 http://togogenome.org/gene/83332:Rv1350 ^@ http://purl.uniprot.org/uniprot/P9WGR9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv1350 ^@ http://purl.uniprot.org/annotation/PRO_0000054858 http://togogenome.org/gene/83332:Rv2197c ^@ http://purl.uniprot.org/uniprot/P9WLI9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2197c ^@ http://purl.uniprot.org/annotation/PRO_0000103971 http://togogenome.org/gene/83332:Rv2741 ^@ http://purl.uniprot.org/uniprot/Q79FB3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS47 ^@ http://purl.uniprot.org/annotation/PRO_5004287628 http://togogenome.org/gene/83332:Rv2024c ^@ http://purl.uniprot.org/uniprot/O53470 ^@ Region ^@ Domain Extent ^@ Helicase ATP-binding ^@ http://togogenome.org/gene/83332:Rv1172c ^@ http://purl.uniprot.org/uniprot/L7N693 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv2851c ^@ http://purl.uniprot.org/uniprot/P9WFQ5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ N-acetyltransferase|||UPF0039 protein Rv2851c ^@ http://purl.uniprot.org/annotation/PRO_0000201921 http://togogenome.org/gene/83332:Rv3731 ^@ http://purl.uniprot.org/uniprot/L0TDE1 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ DNA ligase C|||N6-AMP-lysine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000425953 http://togogenome.org/gene/83332:Rv1834 ^@ http://purl.uniprot.org/uniprot/P9WLR1 ^@ Molecule Processing ^@ Chain ^@ Putative hydrolase LipZ ^@ http://purl.uniprot.org/annotation/PRO_0000103907 http://togogenome.org/gene/83332:Rv0925c ^@ http://purl.uniprot.org/uniprot/I6Y946 ^@ Region ^@ Domain Extent ^@ FMN_red ^@ http://togogenome.org/gene/83332:Rv3869 ^@ http://purl.uniprot.org/uniprot/P9WNR7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Disulfide Bond|||Helix|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ 2-fold increase in ATPase activity (residues 72-448 only).|||6-fold increase in ATPase activity (residues 106-463 only).|||Cytoplasmic|||ESX-1 secretion system ATPase EccB1|||Helical|||No ATPase activity (residues 106-480 only).|||Periplasmic|||Retains 40% ATPase activity (in residues 72-480).|||Retains only 20% decrease ATPase activity (in residues 72-480); probably due to loss of secondary structure. ^@ http://purl.uniprot.org/annotation/PRO_0000393228 http://togogenome.org/gene/83332:Rv0391 ^@ http://purl.uniprot.org/uniprot/P9WGB5 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||O-succinylhomoserine sulfhydrylase ^@ http://purl.uniprot.org/annotation/PRO_0000416406 http://togogenome.org/gene/83332:Rv2145c ^@ http://purl.uniprot.org/uniprot/P9WMU1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Coiled-Coil|||Helix|||Modified Residue|||Mutagenesis Site ^@ Cell wall synthesis protein Wag31|||Increases homooligomerization.|||No interaction with PbpB (PBP3, FtsI). Slower growth, increased sensitivity to H(2)O(2) and to antibiotics ofloxacin and isoniazid, increased degradation of PbpB. Decreased survival in human macrophage line THP-1.|||Phosphothreonine|||Strong decrease in phosphorylation of Wag31. ^@ http://purl.uniprot.org/annotation/PRO_0000064492 http://togogenome.org/gene/83332:Rv0748 ^@ http://purl.uniprot.org/uniprot/O53811 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB31 ^@ http://purl.uniprot.org/annotation/PRO_0000408075 http://togogenome.org/gene/83332:Rv2328 ^@ http://purl.uniprot.org/uniprot/P9WIG9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||PE|||Uncharacterized PE family protein PE23 ^@ http://purl.uniprot.org/annotation/PRO_0000216162 http://togogenome.org/gene/83332:Rv0210 ^@ http://purl.uniprot.org/uniprot/P96392 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1049 ^@ http://purl.uniprot.org/uniprot/I6Y5H3 ^@ Region ^@ Domain Extent ^@ HTH marR-type ^@ http://togogenome.org/gene/83332:Rv1569 ^@ http://purl.uniprot.org/uniprot/P9WQ87 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Mass|||Modified Residue ^@ 8-amino-7-oxononanoate synthase 1|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000163818 http://togogenome.org/gene/83332:Rv1235 ^@ http://purl.uniprot.org/uniprot/P9WGU9 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||S-diacylglycerol cysteine|||Trehalose-binding lipoprotein LpqY ^@ http://purl.uniprot.org/annotation/PRO_0000419317 http://togogenome.org/gene/83332:Rv0873 ^@ http://purl.uniprot.org/uniprot/P9WQF7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Probable acyl-CoA dehydrogenase FadE10|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000201209 http://togogenome.org/gene/83332:Rv3821 ^@ http://purl.uniprot.org/uniprot/O07802 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Sulfolipid-1 exporter Sap ^@ http://purl.uniprot.org/annotation/PRO_0000432808 http://togogenome.org/gene/83332:Rv2905 ^@ http://purl.uniprot.org/uniprot/P9WK67 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppW|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018118 http://togogenome.org/gene/83332:Rv1540 ^@ http://purl.uniprot.org/uniprot/P9WHQ3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ S4 RNA-binding|||Uncharacterized RNA pseudouridine synthase Rv1540 ^@ http://purl.uniprot.org/annotation/PRO_0000162743 http://togogenome.org/gene/83332:Rv1015c ^@ http://purl.uniprot.org/uniprot/P9WHB5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 50S ribosomal protein L25|||Acidic residues|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000181570 http://togogenome.org/gene/83332:Rv2612c ^@ http://purl.uniprot.org/uniprot/P9WPG7 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ 2-fold decrease in catalytic activity.|||Almost loss of catalytic activity.|||Helical|||Large decrease in catalytic activity.|||No change in catalytic activity.|||Phosphatidylinositol phosphate synthase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000393108 http://togogenome.org/gene/83332:Rv3198c ^@ http://purl.uniprot.org/uniprot/P9WMP9 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ ATP-dependent DNA helicase UvrD2|||HRDC|||Loss of growth, no ATPase activity. No DNA unwinding. Does not translocate along DNA.|||Not essential for growth, no helicase activity. Wild-type ATPase activity, translocates along DNA. No DNA unwinding.|||UvrD-like helicase ATP-binding|||UvrD-like helicase C-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000102079 http://togogenome.org/gene/83332:Rv0445c ^@ http://purl.uniprot.org/uniprot/P9WGH7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif|||Turn ^@ ECF RNA polymerase sigma factor SigK|||H-T-H motif|||Interaction with polymerase core subunit RpoC ^@ http://purl.uniprot.org/annotation/PRO_0000313845 http://togogenome.org/gene/83332:Rv1846c ^@ http://purl.uniprot.org/uniprot/P9WMJ5 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Strand|||Turn ^@ H-T-H motif|||Transcriptional regulator BlaI ^@ http://purl.uniprot.org/annotation/PRO_0000371419 http://togogenome.org/gene/83332:Rv2201 ^@ http://purl.uniprot.org/uniprot/P9WN33 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Initiator Methionine ^@ For GATase activity|||Glutamine amidotransferase type-2|||Putative asparagine synthetase [glutamine-hydrolyzing]|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000056935 http://togogenome.org/gene/83332:Rv3386 ^@ http://purl.uniprot.org/uniprot/O50413 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||DUF772 ^@ http://togogenome.org/gene/83332:Rv1091 ^@ http://purl.uniprot.org/uniprot/Q79FS5 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv3016 ^@ http://purl.uniprot.org/uniprot/I6Y2A3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PknH_C ^@ http://purl.uniprot.org/annotation/PRO_5010317640 http://togogenome.org/gene/83332:Rv3882c ^@ http://purl.uniprot.org/uniprot/P9WJE9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-1 secretion system protein EccE1|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393869 http://togogenome.org/gene/83332:Rv1658 ^@ http://purl.uniprot.org/uniprot/P9WPW7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Argininosuccinate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000148616 http://togogenome.org/gene/83332:Rv2840c ^@ http://purl.uniprot.org/uniprot/I6XFF7 ^@ Region ^@ Domain Extent ^@ YlxR ^@ http://togogenome.org/gene/83332:Rv3202c ^@ http://purl.uniprot.org/uniprot/O53348 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ UvrD-like helicase ATP-binding|||UvrD-like helicase C-terminal ^@ http://togogenome.org/gene/83332:Rv0085 ^@ http://purl.uniprot.org/uniprot/P9WM75 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0085 ^@ http://purl.uniprot.org/annotation/PRO_0000103660 http://togogenome.org/gene/83332:Rv3712 ^@ http://purl.uniprot.org/uniprot/I6Y4C7 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ MurT_C|||Mur_ligase_M ^@ http://togogenome.org/gene/83332:Rv3165c ^@ http://purl.uniprot.org/uniprot/O53315 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0049 ^@ http://purl.uniprot.org/uniprot/P9WM85 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0049 ^@ http://purl.uniprot.org/annotation/PRO_0000103658 http://togogenome.org/gene/83332:Rv0567 ^@ http://purl.uniprot.org/uniprot/O53764 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Dimerisation2|||Methyltransf_2|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2602 ^@ http://purl.uniprot.org/uniprot/P9WF59 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC41 ^@ http://purl.uniprot.org/annotation/PRO_0000407895 http://togogenome.org/gene/83332:Rv1575 ^@ http://purl.uniprot.org/uniprot/L0T9U5 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv0705 ^@ http://purl.uniprot.org/uniprot/P9WH45 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S19 ^@ http://purl.uniprot.org/annotation/PRO_0000129856 http://togogenome.org/gene/83332:Rv1246c ^@ http://purl.uniprot.org/uniprot/O50461 ^@ Molecule Processing ^@ Chain ^@ Toxin RelE ^@ http://purl.uniprot.org/annotation/PRO_0000406199 http://togogenome.org/gene/83332:Rv2064 ^@ http://purl.uniprot.org/uniprot/Q10675 ^@ Region ^@ Domain Extent ^@ NIR_SIR_ferr ^@ http://togogenome.org/gene/83332:Rv3831 ^@ http://purl.uniprot.org/uniprot/P96247 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1066 ^@ http://purl.uniprot.org/uniprot/O53414 ^@ Region ^@ Domain Extent ^@ Rhodanese ^@ http://togogenome.org/gene/83332:Rv0538 ^@ http://purl.uniprot.org/uniprot/O06404 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2240c ^@ http://purl.uniprot.org/uniprot/P9WLG7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2240c ^@ http://purl.uniprot.org/annotation/PRO_0000103989 http://togogenome.org/gene/83332:Rv1896c ^@ http://purl.uniprot.org/uniprot/P9WFH7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv1896c ^@ http://purl.uniprot.org/annotation/PRO_0000361238 http://togogenome.org/gene/83332:Rv2207 ^@ http://purl.uniprot.org/uniprot/P9WP85 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000167056 http://togogenome.org/gene/83332:Rv2853 ^@ http://purl.uniprot.org/uniprot/Q6MX26 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2034 ^@ http://purl.uniprot.org/uniprot/O53478 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Mutagenesis Site ^@ Does not bind DNA and does not form dimers.|||Does not bind DNA, but retains the capacity to form dimers; when associated with G-32.|||Does not bind DNA, but retains the capacity to form dimers; when associated with G-35.|||H-T-H motif|||HTH arsR-type|||HTH-type transcriptional regulator Rv2034 ^@ http://purl.uniprot.org/annotation/PRO_0000419177 http://togogenome.org/gene/83332:Rv1342c ^@ http://purl.uniprot.org/uniprot/P9WM19 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ Helical|||N-acetylthreonine|||Removed|||Uncharacterized protein Rv1342c ^@ http://purl.uniprot.org/annotation/PRO_0000103814 http://togogenome.org/gene/83332:Rv2549c ^@ http://purl.uniprot.org/uniprot/P95004 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ 23S rRNA-specific endonuclease VapC20|||Loss of 23S rRNA cleavage.|||PINc ^@ http://purl.uniprot.org/annotation/PRO_0000407879 http://togogenome.org/gene/83332:Rv2864c ^@ http://purl.uniprot.org/uniprot/O33346 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ MecA_N|||Transpeptidase ^@ http://purl.uniprot.org/annotation/PRO_5010175675 http://togogenome.org/gene/83332:Rv0655 ^@ http://purl.uniprot.org/uniprot/P9WQL5 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Modified Residue ^@ ABC transporter|||N6-acetyllysine|||Probable ribonucleotide transport ATP-binding protein mkl ^@ http://purl.uniprot.org/annotation/PRO_0000092521 http://togogenome.org/gene/83332:Rv3743c ^@ http://purl.uniprot.org/uniprot/P9WPT7 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Helical|||Probable cation-transporting P-type ATPase J ^@ http://purl.uniprot.org/annotation/PRO_0000419203 http://togogenome.org/gene/83332:Rv3213c ^@ http://purl.uniprot.org/uniprot/O05853 ^@ Region ^@ Domain Extent ^@ AAA_31 ^@ http://togogenome.org/gene/83332:Rv3705A ^@ http://purl.uniprot.org/uniprot/I6YGY9 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2155c ^@ http://purl.uniprot.org/uniprot/P9WJL5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ UDP-N-acetylmuramoylalanine--D-glutamate ligase ^@ http://purl.uniprot.org/annotation/PRO_0000109046 http://togogenome.org/gene/83332:Rv2386a ^@ http://purl.uniprot.org/uniprot/I6YD99 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2386A/RVBD_2386A ^@ http://purl.uniprot.org/annotation/PRO_0000431253 http://togogenome.org/gene/83332:Rv0761c ^@ http://purl.uniprot.org/uniprot/P9WQC7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Alcohol dehydrogenase B ^@ http://purl.uniprot.org/annotation/PRO_0000160743 http://togogenome.org/gene/83332:Rv0226c ^@ http://purl.uniprot.org/uniprot/P96408 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1062 ^@ http://purl.uniprot.org/uniprot/O53410 ^@ Region|||Site ^@ Active Site|||Domain Extent|||Motif ^@ DGA/G|||GXGXXG|||GXSXG|||Nucleophile|||PNPLA|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv0054 ^@ http://purl.uniprot.org/uniprot/P9WGD5 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Strand|||Turn ^@ Polar residues|||SSB|||Single-stranded DNA-binding protein ^@ http://purl.uniprot.org/annotation/PRO_0000096069 http://togogenome.org/gene/83332:Rv0884c ^@ http://purl.uniprot.org/uniprot/P9WQ73 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylalanine|||N6-(pyridoxal phosphate)lysine|||Phosphoserine aminotransferase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000150188 http://togogenome.org/gene/83332:Rv1721c ^@ http://purl.uniprot.org/uniprot/P9WJ53 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB12 ^@ http://purl.uniprot.org/annotation/PRO_0000408059 http://togogenome.org/gene/83332:Rv1552 ^@ http://purl.uniprot.org/uniprot/P9WN91 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Modified Residue ^@ Fumarate reductase flavoprotein subunit|||Tele-8alpha-FAD histidine ^@ http://purl.uniprot.org/annotation/PRO_0000158664 http://togogenome.org/gene/83332:Rv2391 ^@ http://purl.uniprot.org/uniprot/P9WJ03 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 3'-(S-cysteinyl)-tyrosine (Tyr-Cys)|||Strong decrease in activity.|||Sulfite reductase [ferredoxin]|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000199952 http://togogenome.org/gene/83332:Rv3209 ^@ http://purl.uniprot.org/uniprot/O05857 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide ^@ Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5010303085 http://togogenome.org/gene/83332:Rv0457c ^@ http://purl.uniprot.org/uniprot/O07178 ^@ Region ^@ Domain Extent ^@ Peptidase_S9|||Peptidase_S9_N ^@ http://togogenome.org/gene/83332:Rv1856c ^@ http://purl.uniprot.org/uniprot/P9WGQ1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative oxidoreductase Rv1856c ^@ http://purl.uniprot.org/annotation/PRO_0000415509 http://togogenome.org/gene/83332:Rv2211c ^@ http://purl.uniprot.org/uniprot/P9WN51 ^@ Molecule Processing ^@ Chain ^@ Aminomethyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000122574 http://togogenome.org/gene/83332:Rv3397c ^@ http://purl.uniprot.org/uniprot/P9WHP3 ^@ Molecule Processing ^@ Chain ^@ Phytoene synthase ^@ http://purl.uniprot.org/annotation/PRO_0000067431 http://togogenome.org/gene/83332:Rv3030 ^@ http://purl.uniprot.org/uniprot/P9WJZ1 ^@ Molecule Processing ^@ Chain ^@ Probable S-adenosylmethionine-dependent methyltransferase Rv3030 ^@ http://purl.uniprot.org/annotation/PRO_0000413014 http://togogenome.org/gene/83332:Rv3894c ^@ http://purl.uniprot.org/uniprot/O05450 ^@ Region|||Site ^@ Binding Site|||Domain Extent|||Transmembrane ^@ FtsK|||Helical ^@ http://togogenome.org/gene/83332:Rv1670 ^@ http://purl.uniprot.org/uniprot/O53917 ^@ Region ^@ Domain Extent ^@ NTP_transf_9 ^@ http://togogenome.org/gene/83332:Rv2510c ^@ http://purl.uniprot.org/uniprot/I6Y0X6 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ HerA_C|||Pro residues ^@ http://togogenome.org/gene/83332:Rv3722c ^@ http://purl.uniprot.org/uniprot/O69689 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Aspartate aminotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000450667 http://togogenome.org/gene/83332:Rv0577 ^@ http://purl.uniprot.org/uniprot/P9WIR3 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Putative glyoxylase CFP32|||VOC 1|||VOC 2 ^@ http://purl.uniprot.org/annotation/PRO_0000089565 http://togogenome.org/gene/83332:Rv3524 ^@ http://purl.uniprot.org/uniprot/I6X7J6 ^@ Region ^@ Compositionally Biased Region|||Repeat|||Transmembrane ^@ Helical|||NHL|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2614c ^@ http://purl.uniprot.org/uniprot/P9WFT5 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ N-acetylserine|||Removed|||TGS|||Threonine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000101012 http://togogenome.org/gene/83332:Rv0405 ^@ http://purl.uniprot.org/uniprot/O86335 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv1256c ^@ http://purl.uniprot.org/uniprot/P9WPN5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Cytochrome P450 130|||The binding mode of azoles and some arylamines are reverted from type II to type I because of hydrophobic and steric interactions with the alanine side chain.|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052285 http://togogenome.org/gene/83332:Rv0715 ^@ http://purl.uniprot.org/uniprot/P9WHB7 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L24 ^@ http://purl.uniprot.org/annotation/PRO_0000130684 http://togogenome.org/gene/83332:Rv3336c ^@ http://purl.uniprot.org/uniprot/P9WFT3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ 'HIGH' region|||'KMSKS' region|||Tryptophan--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000136651 http://togogenome.org/gene/83332:Rv0894 ^@ http://purl.uniprot.org/uniprot/P9WKP9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized protein Rv0894 ^@ http://purl.uniprot.org/annotation/PRO_0000103735 http://togogenome.org/gene/83332:Rv3841 ^@ http://purl.uniprot.org/uniprot/P9WNE5 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Mutagenesis Site|||Turn ^@ Bacterioferritin BfrB|||Ferritin-like diiron|||No large change in protein assembly or structure, decreased thermostability, 3.5-fold reduction in oxidation of Fe(2+), 20% reduction in Fe(3+) release rate.|||Protein no longer targeted to encapsulin nanocompartments.|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000392942 http://togogenome.org/gene/83332:Rv1079 ^@ http://purl.uniprot.org/uniprot/P9WGB7 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ Cystathionine gamma-synthase|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000114762 http://togogenome.org/gene/83332:Rv0548c ^@ http://purl.uniprot.org/uniprot/P9WNP5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 1,4-dihydroxy-2-naphthoyl-CoA synthase|||Loss of DHNA-CoA synthase activity.|||Nearly abolishes DHNA-CoA synthase activity.|||Reduces affinity for substrate. Nearly abolishes DHNA-CoA synthase activity.|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000399471 http://togogenome.org/gene/83332:Rv1906c ^@ http://purl.uniprot.org/uniprot/O07726 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010288531 http://togogenome.org/gene/83332:Rv2732c ^@ http://purl.uniprot.org/uniprot/O33237 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1367c ^@ http://purl.uniprot.org/uniprot/P9WLZ3 ^@ Molecule Processing ^@ Chain ^@ Protein Rv1367c ^@ http://purl.uniprot.org/annotation/PRO_0000103836 http://togogenome.org/gene/83332:Rv1396c ^@ http://purl.uniprot.org/uniprot/P71664 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5004161249 http://togogenome.org/gene/83332:Rv2910c ^@ http://purl.uniprot.org/uniprot/P9WL25 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2910c ^@ http://purl.uniprot.org/annotation/PRO_0000104098 http://togogenome.org/gene/83332:Rv2559c ^@ http://purl.uniprot.org/uniprot/P9WQN1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized AAA domain-containing protein Rv2559c ^@ http://purl.uniprot.org/annotation/PRO_0000104039 http://togogenome.org/gene/83332:Rv1690 ^@ http://purl.uniprot.org/uniprot/O33192 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Lipid Binding|||Mutagenesis Site|||Signal Peptide|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||Helical|||Increases KdpD induction at 0 and 250 uM K(+).|||N-palmitoyl cysteine|||Putative lipoprotein LprJ|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000434609 http://togogenome.org/gene/83332:Rv3408 ^@ http://purl.uniprot.org/uniprot/P9WF49 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC47 ^@ http://purl.uniprot.org/annotation/PRO_0000104129 http://togogenome.org/gene/83332:Rv2874 ^@ http://purl.uniprot.org/uniprot/P9WG63 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Transmembrane|||Turn ^@ Helical|||Protein DipZ|||Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000079911 http://togogenome.org/gene/83332:Rv0665 ^@ http://purl.uniprot.org/uniprot/P9WFB1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC8 ^@ http://purl.uniprot.org/annotation/PRO_0000407871 http://togogenome.org/gene/83332:Rv1206 ^@ http://purl.uniprot.org/uniprot/O05307 ^@ Molecule Processing ^@ Chain ^@ Medium/long-chain-fatty-acid--CoA ligase FadD6 ^@ http://purl.uniprot.org/annotation/PRO_0000451298 http://togogenome.org/gene/83332:Rv2379c ^@ http://purl.uniprot.org/uniprot/O05819 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv3225c ^@ http://purl.uniprot.org/uniprot/O05841 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv3820c ^@ http://purl.uniprot.org/uniprot/P9WIK7 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ Loss of sulfolipid-1 (SL-1) production.|||Trehalose-2-sulfate acyltransferase PapA2 ^@ http://purl.uniprot.org/annotation/PRO_0000314662 http://togogenome.org/gene/83332:Rv1336 ^@ http://purl.uniprot.org/uniprot/P9WP53 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 700-fold decrease in the rate of the first half-reaction using OPS. Affects neither the rate of the first half-reaction using OAS nor the rate of the second half-reaction using sulfide or CysO-COSH.|||Decreased lifetime of the alpha-aminoacrylate reaction intermediate, increased susceptibility to oxidation by oxidative agents such as hydrogen peroxide, and partial loss of selectivity towards CysO-COSH as sulfur donor.|||N6-(pyridoxal phosphate)lysine|||O-phosphoserine sulfhydrylase ^@ http://purl.uniprot.org/annotation/PRO_0000167112 http://togogenome.org/gene/83332:Rv0095c ^@ http://purl.uniprot.org/uniprot/Q10891 ^@ Molecule Processing ^@ Chain ^@ Putative uncharacterized protein Rv0095c ^@ http://purl.uniprot.org/annotation/PRO_0000103667 http://togogenome.org/gene/83332:Rv3892c ^@ http://purl.uniprot.org/uniprot/P9WHW7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE69 ^@ http://purl.uniprot.org/annotation/PRO_0000379594 http://togogenome.org/gene/83332:Rv3536c ^@ http://purl.uniprot.org/uniprot/I6XHH5 ^@ Region ^@ Domain Extent ^@ FAA_hydrolase ^@ http://togogenome.org/gene/83332:Rv0236c ^@ http://purl.uniprot.org/uniprot/P96419 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Alpha-(1->3)-arabinofuranosyltransferase|||F5/8 type C|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000420582 http://togogenome.org/gene/83332:Rv0766c ^@ http://purl.uniprot.org/uniprot/P9WPP5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 123|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052276 http://togogenome.org/gene/83332:Rv1595 ^@ http://purl.uniprot.org/uniprot/P9WJJ9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ L-aspartate oxidase|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000184389 http://togogenome.org/gene/83332:Rv0726c ^@ http://purl.uniprot.org/uniprot/P9WFI7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0726c ^@ http://purl.uniprot.org/annotation/PRO_0000361242 http://togogenome.org/gene/83332:Rv3353c ^@ http://purl.uniprot.org/uniprot/O50382 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Oxidoreductase ^@ http://purl.uniprot.org/annotation/PRO_5010335829 http://togogenome.org/gene/83332:Rv2822c ^@ http://purl.uniprot.org/uniprot/P9WJG1 ^@ Molecule Processing ^@ Chain ^@ CRISPR system Cms protein Csm2 ^@ http://purl.uniprot.org/annotation/PRO_0000418225 http://togogenome.org/gene/83332:Rv0067c ^@ http://purl.uniprot.org/uniprot/O53612 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0559c ^@ http://purl.uniprot.org/uniprot/P9WKL3 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv0559c ^@ http://purl.uniprot.org/annotation/PRO_0000419778 http://togogenome.org/gene/83332:Rv1731 ^@ http://purl.uniprot.org/uniprot/P9WNX7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Nucleophile|||Proton acceptor|||Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2 ^@ http://purl.uniprot.org/annotation/PRO_0000310711 http://togogenome.org/gene/83332:Rv3500c ^@ http://purl.uniprot.org/uniprot/I6Y3P5 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2250c ^@ http://purl.uniprot.org/uniprot/P9WMC5 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv2250c ^@ http://purl.uniprot.org/annotation/PRO_0000070670 http://togogenome.org/gene/83332:Rv0364 ^@ http://purl.uniprot.org/uniprot/P9WP09 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein Rv0364 ^@ http://purl.uniprot.org/annotation/PRO_0000161428 http://togogenome.org/gene/83332:Rv1565c ^@ http://purl.uniprot.org/uniprot/O06625 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Acyl_transf_3|||Helical|||SGNH ^@ http://togogenome.org/gene/83332:Rv2403c ^@ http://purl.uniprot.org/uniprot/P71740 ^@ Region ^@ Domain Extent ^@ PknH_C ^@ http://togogenome.org/gene/83332:Rv0187 ^@ http://purl.uniprot.org/uniprot/O07431 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand ^@ Catechol O-methyltransferase|||Retains a low but substantial activity. ^@ http://purl.uniprot.org/annotation/PRO_0000448281 http://togogenome.org/gene/83332:Rv3765c ^@ http://purl.uniprot.org/uniprot/O69730 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Modified Residue|||Sequence Conflict ^@ 4-aspartylphosphate|||OmpR/PhoB-type|||Probable transcriptional regulatory protein TcrX|||Response regulatory ^@ http://purl.uniprot.org/annotation/PRO_0000412201 http://togogenome.org/gene/83332:Rv0676c ^@ http://purl.uniprot.org/uniprot/P9WJV1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Siderophore exporter MmpL5 ^@ http://purl.uniprot.org/annotation/PRO_0000103568 http://togogenome.org/gene/83332:Rv1867 ^@ http://purl.uniprot.org/uniprot/P95148 ^@ Region ^@ Domain Extent ^@ TLP1_add_C ^@ http://togogenome.org/gene/83332:Rv2221c ^@ http://purl.uniprot.org/uniprot/P9WN27 ^@ Molecule Processing ^@ Chain ^@ Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme ^@ http://purl.uniprot.org/annotation/PRO_0000209257 http://togogenome.org/gene/83332:Rv2521 ^@ http://purl.uniprot.org/uniprot/P9WIE1 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Crosslink|||Disulfide Bond|||Domain Extent ^@ Cysteine sulfenic acid (-SOH) intermediate|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Putative peroxiredoxin Rv2521|||Redox-active|||Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000396096 http://togogenome.org/gene/83332:Rv3733c ^@ http://purl.uniprot.org/uniprot/O69700 ^@ Region ^@ Domain Extent ^@ Nudix hydrolase ^@ http://togogenome.org/gene/83332:Rv0588 ^@ http://purl.uniprot.org/uniprot/O07790 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2343c ^@ http://purl.uniprot.org/uniprot/P9WNW1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn|||Zinc Finger ^@ CHC2-type|||DNA primase|||Toprim ^@ http://purl.uniprot.org/annotation/PRO_0000180506 http://togogenome.org/gene/83332:Rv3181c ^@ http://purl.uniprot.org/uniprot/P9WF15 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB49 ^@ http://purl.uniprot.org/annotation/PRO_0000408049 http://togogenome.org/gene/83332:Rv0415 ^@ http://purl.uniprot.org/uniprot/P96261 ^@ Region ^@ Domain Extent ^@ DAO ^@ http://togogenome.org/gene/83332:Rv1266c ^@ http://purl.uniprot.org/uniprot/P9WI71 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Disulfide Bond|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Abolished autophosphorylation.|||Abolished kinase activity.|||Cytoplasmic|||Extracellular|||Helical|||Phosphothreonine|||Pro residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknH ^@ http://purl.uniprot.org/annotation/PRO_0000171218 http://togogenome.org/gene/83332:Rv3002c ^@ http://purl.uniprot.org/uniprot/P9WKJ3 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Crosslink|||Domain Extent ^@ ACT|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Putative acetolactate synthase small subunit ^@ http://purl.uniprot.org/annotation/PRO_0000151416 http://togogenome.org/gene/83332:Rv3851 ^@ http://purl.uniprot.org/uniprot/P96226 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical ^@ http://purl.uniprot.org/annotation/PRO_5010237693 http://togogenome.org/gene/83332:Rv1095 ^@ http://purl.uniprot.org/uniprot/O53443 ^@ Region ^@ Domain Extent ^@ PINc ^@ http://togogenome.org/gene/83332:Rv1923 ^@ http://purl.uniprot.org/uniprot/P95290 ^@ Region ^@ Domain Extent ^@ Beta-lactamase ^@ http://togogenome.org/gene/83332:Rv2743c ^@ http://purl.uniprot.org/uniprot/I6YA50 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative envelope-preserving system protein Rv2743c ^@ http://purl.uniprot.org/annotation/PRO_0000450868 http://togogenome.org/gene/83332:Rv1380 ^@ http://purl.uniprot.org/uniprot/P9WIT7 ^@ Molecule Processing ^@ Chain ^@ Aspartate carbamoyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000113163 http://togogenome.org/gene/83332:Rv1735c ^@ http://purl.uniprot.org/uniprot/P9WLS5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein Rv1735c ^@ http://purl.uniprot.org/annotation/PRO_0000392908 http://togogenome.org/gene/83332:Rv2921c ^@ http://purl.uniprot.org/uniprot/P9WGD9 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Mutagenesis Site ^@ Polar residues|||Severely affects the affinity toward GTP and causes a significant decrease in enzyme activity.|||Signal recognition particle receptor FtsY ^@ http://purl.uniprot.org/annotation/PRO_0000101139 http://togogenome.org/gene/83332:Rv1700 ^@ http://purl.uniprot.org/uniprot/I6X235 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Motif|||Mutagenesis Site|||Strand|||Turn ^@ 2.1-fold decrease in KM for ADPR. 1940-fold decrease in kcat with ADPR as substrate.|||2.3-fold decrease in KM for ADPR. 1150-fold decrease in kcat with ADPR as substrate.|||2.7-fold decrease in KM for ADPR. 300-fold decrease in kcat with ADPR as substrate.|||3-fold decrease in KM for ADPR. 910-fold decrease in kcat with ADPR as substrate.|||ADP-ribose pyrophosphatase|||Nudix box|||Nudix hydrolase|||Proton acceptor|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000449350 http://togogenome.org/gene/83332:Rv2571c ^@ http://purl.uniprot.org/uniprot/P9WL89 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative arylamide transporter ^@ http://purl.uniprot.org/annotation/PRO_0000104052 http://togogenome.org/gene/83332:Rv1217c ^@ http://purl.uniprot.org/uniprot/O05318 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Multidrug efflux system permease protein Rv1217c ^@ http://purl.uniprot.org/annotation/PRO_0000447331 http://togogenome.org/gene/83332:Rv3418c ^@ http://purl.uniprot.org/uniprot/P9WPE5 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Crosslink|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Co-chaperonin GroES|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylalanine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000174788 http://togogenome.org/gene/83332:Rv3238c ^@ http://purl.uniprot.org/uniprot/O05883 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Methanethiol S-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000444498 http://togogenome.org/gene/83332:Rv1347c ^@ http://purl.uniprot.org/uniprot/P9WK15 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Lysine N-acyltransferase MbtK|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000103819 http://togogenome.org/gene/83332:Rv0107c ^@ http://purl.uniprot.org/uniprot/P9WPS5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Helical|||Polar residues|||Probable cation-transporting ATPase I ^@ http://purl.uniprot.org/annotation/PRO_0000046347 http://togogenome.org/gene/83332:Rv2530A ^@ http://purl.uniprot.org/uniprot/P9WJ23 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB39 ^@ http://purl.uniprot.org/annotation/PRO_0000408081 http://togogenome.org/gene/83332:Rv3035 ^@ http://purl.uniprot.org/uniprot/I6XFZ8 ^@ Molecule Processing ^@ Chain ^@ Protein Rv3035 ^@ http://purl.uniprot.org/annotation/PRO_0000432519 http://togogenome.org/gene/83332:Rv3548c ^@ http://purl.uniprot.org/uniprot/P71853 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv3909 ^@ http://purl.uniprot.org/uniprot/O05436 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010237692 http://togogenome.org/gene/83332:Rv0247c ^@ http://purl.uniprot.org/uniprot/O53669 ^@ Region ^@ Domain Extent ^@ 2Fe-2S ferredoxin-type ^@ http://togogenome.org/gene/83332:Rv0425c ^@ http://purl.uniprot.org/uniprot/P96271 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Cation_ATPase_C|||Helical|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5010193820 http://togogenome.org/gene/83332:Rv2008c ^@ http://purl.uniprot.org/uniprot/P9WLM9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized protein Rv2008c ^@ http://purl.uniprot.org/annotation/PRO_0000103936 http://togogenome.org/gene/83332:Rv1606 ^@ http://purl.uniprot.org/uniprot/P9WMM7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Phosphoribosyl-AMP cyclohydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000136486 http://togogenome.org/gene/83332:Rv2832c ^@ http://purl.uniprot.org/uniprot/I6X5H3 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv0077c ^@ http://purl.uniprot.org/uniprot/O53622 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv3516 ^@ http://purl.uniprot.org/uniprot/O53561 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Modified Residue|||Mutagenesis Site ^@ About 50% succinylation in vitro, reduces specific activity 7-fold.|||Enoyl-CoA hydratase EchA19|||N6-succinyllysine|||Nearly wild-type levels of succinylation in vitro, reduces specific activity 8-fold.|||Very low levels of succinylation in vitro, reduces specific activity 15-fold. ^@ http://purl.uniprot.org/annotation/PRO_0000456533 http://togogenome.org/gene/83332:Rv0374c ^@ http://purl.uniprot.org/uniprot/O53709 ^@ Region ^@ Domain Extent ^@ 2Fe-2S ferredoxin-type ^@ http://togogenome.org/gene/83332:Rv0899 ^@ http://purl.uniprot.org/uniprot/P9WIU5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Disulfide Bond|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ BON|||Decreases structure stability of OmpA-like domain.|||Helical|||Increases conformational stability of OmpA-like domain. Does not alter peptidoglycan-binding.|||Loss of peptidoglycan-binding; in association with A236.|||OmpA-like|||Peptidoglycan-binding protein ArfA|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000196259 http://togogenome.org/gene/83332:Rv1237 ^@ http://purl.uniprot.org/uniprot/P9WG01 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Trehalose transport system permease protein SugB ^@ http://purl.uniprot.org/annotation/PRO_0000419316 http://togogenome.org/gene/83332:Rv2931 ^@ http://purl.uniprot.org/uniprot/P9WQE7 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ Carrier 1|||Carrier 2|||For beta-ketoacyl synthase activity|||For malonyltransferase activity|||Ketosynthase family 3 (KS3)|||N-acetylthreonine|||O-(pantetheine 4'-phosphoryl)serine|||Phenolphthiocerol/phthiocerol polyketide synthase subunit A|||Polar residues|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000180301 http://togogenome.org/gene/83332:Rv0197 ^@ http://purl.uniprot.org/uniprot/L0T2Z1 ^@ Region ^@ Domain Extent ^@ 4Fe-4S Mo/W bis-MGD-type ^@ http://togogenome.org/gene/83332:Rv2414c ^@ http://purl.uniprot.org/uniprot/P71729 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Competence|||Helical ^@ http://togogenome.org/gene/83332:Rv1911c ^@ http://purl.uniprot.org/uniprot/P9WFN3 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Polar residues|||Putative lipoprotein LppC|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000137907 http://togogenome.org/gene/83332:Rv0687 ^@ http://purl.uniprot.org/uniprot/P9WGS7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized NAD-dependent oxidoreductase Rv0687 ^@ http://purl.uniprot.org/annotation/PRO_0000416411 http://togogenome.org/gene/83332:Rv1877 ^@ http://purl.uniprot.org/uniprot/P9WG85 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized MFS-type transporter Rv1877 ^@ http://purl.uniprot.org/annotation/PRO_0000390887 http://togogenome.org/gene/83332:Rv0055 ^@ http://purl.uniprot.org/uniprot/P9WH49 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S18 1 ^@ http://purl.uniprot.org/annotation/PRO_0000111190 http://togogenome.org/gene/83332:Rv2231c ^@ http://purl.uniprot.org/uniprot/P9WQ89 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Uncharacterized aminotransferase Rv2231c ^@ http://purl.uniprot.org/annotation/PRO_0000123927 http://togogenome.org/gene/83332:Rv0869c ^@ http://purl.uniprot.org/uniprot/P9WJS1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ GTP 3',8-cyclase 2|||Radical SAM core ^@ http://purl.uniprot.org/annotation/PRO_0000152977 http://togogenome.org/gene/83332:Rv1468c ^@ http://purl.uniprot.org/uniprot/Q79FP0 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Mutagenesis Site ^@ Abolishes interaction with host ubiquitin, impairs host xenophagy and increases bacterial loads in mice with enhanced inflammatory responses.|||PE|||Reduces interaction with host ubiquitin.|||Reduces interaction with host ubiquitin. Shows enhanced viability, reduced p62 aggregation and reduced colocalization with LC3 and LAMP1 in BMDMs.|||Ubiquitin-binding protein Rv1468c ^@ http://purl.uniprot.org/annotation/PRO_5004286516 http://togogenome.org/gene/83332:Rv2532c ^@ http://purl.uniprot.org/uniprot/P95021 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Antitermination protein NusB|||Helical ^@ http://purl.uniprot.org/annotation/PRO_5010175676 http://togogenome.org/gene/83332:Rv3045 ^@ http://purl.uniprot.org/uniprot/P9WQC5 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink|||Initiator Methionine|||Modified Residue ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylserine|||NADP-dependent alcohol dehydrogenase C|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000160745 http://togogenome.org/gene/83332:Rv0064A ^@ http://purl.uniprot.org/uniprot/P0CW29 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB1 ^@ http://purl.uniprot.org/annotation/PRO_0000408051 http://togogenome.org/gene/83332:Rv0600c ^@ http://purl.uniprot.org/uniprot/O07778 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||Histidine kinase; second part|||Sensor histidine kinase component HK1 ^@ http://purl.uniprot.org/annotation/PRO_0000391079 http://togogenome.org/gene/83332:Rv0260c ^@ http://purl.uniprot.org/uniprot/P95217 ^@ Region ^@ DNA Binding|||Domain Extent ^@ OmpR/PhoB-type ^@ http://togogenome.org/gene/83332:Rv2881c ^@ http://purl.uniprot.org/uniprot/P9WPF7 ^@ Modification|||Molecule Processing|||Natural Variation|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue|||Splice Variant|||Transmembrane ^@ Helical|||In isoform 2.|||N-acetylthreonine|||Phosphatidate cytidylyltransferase|||Polar residues|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000090743|||http://purl.uniprot.org/annotation/VSP_059173|||http://purl.uniprot.org/annotation/VSP_059174 http://togogenome.org/gene/83332:Rv2358 ^@ http://purl.uniprot.org/uniprot/P9WMI5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH arsR-type|||HTH-type transcriptional repressor SmtB ^@ http://purl.uniprot.org/annotation/PRO_0000419166 http://togogenome.org/gene/83332:Rv3195 ^@ http://purl.uniprot.org/uniprot/O53341 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv2842c ^@ http://purl.uniprot.org/uniprot/P9WH17 ^@ Molecule Processing ^@ Chain ^@ Ribosome maturation factor RimP ^@ http://purl.uniprot.org/annotation/PRO_0000181892 http://togogenome.org/gene/83332:Rv0087 ^@ http://purl.uniprot.org/uniprot/Q10884 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Complex1_30kDa|||Complex1_49kDa ^@ http://togogenome.org/gene/83332:Rv1276c ^@ http://purl.uniprot.org/uniprot/P9WGF9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1276c ^@ http://purl.uniprot.org/annotation/PRO_0000214573 http://togogenome.org/gene/83332:Rv3013 ^@ http://purl.uniprot.org/uniprot/O53260 ^@ Region ^@ Domain Extent ^@ ACT ^@ http://togogenome.org/gene/83332:Rv1107c ^@ http://purl.uniprot.org/uniprot/P9WF29 ^@ Molecule Processing ^@ Chain ^@ Exodeoxyribonuclease 7 small subunit ^@ http://purl.uniprot.org/annotation/PRO_0000206975 http://togogenome.org/gene/83332:Rv1933c ^@ http://purl.uniprot.org/uniprot/P95281 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv0207c ^@ http://purl.uniprot.org/uniprot/P96389 ^@ Region ^@ Domain Extent ^@ NYN ^@ http://togogenome.org/gene/83332:Rv1745c ^@ http://purl.uniprot.org/uniprot/P9WKK5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ Isopentenyl-diphosphate Delta-isomerase|||Nudix hydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000205254 http://togogenome.org/gene/83332:Rv2242 ^@ http://purl.uniprot.org/uniprot/P9WPH5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2242 ^@ http://purl.uniprot.org/annotation/PRO_0000165949 http://togogenome.org/gene/83332:Rv3432c ^@ http://purl.uniprot.org/uniprot/I6YG46 ^@ Modification ^@ Modified Residue ^@ N6-(pyridoxal phosphate)lysine ^@ http://togogenome.org/gene/83332:Rv1227c ^@ http://purl.uniprot.org/uniprot/O33223 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||bPH_2 ^@ http://togogenome.org/gene/83332:Rv1562c ^@ http://purl.uniprot.org/uniprot/P9WQ23 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Malto-oligosyltrehalose trehalohydrolase|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000054324 http://togogenome.org/gene/83332:Rv3249c ^@ http://purl.uniprot.org/uniprot/O05892 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0152c ^@ http://purl.uniprot.org/uniprot/Q79G05 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ Basic residues|||PE-PPE ^@ http://purl.uniprot.org/annotation/PRO_5010241354 http://togogenome.org/gene/83332:Rv0118c ^@ http://purl.uniprot.org/uniprot/O53639 ^@ Region ^@ Domain Extent ^@ TPP_enzyme_C|||TPP_enzyme_M|||TPP_enzyme_N ^@ http://togogenome.org/gene/83332:Rv1881c ^@ http://purl.uniprot.org/uniprot/O07750 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Probable lipoprotein LppE|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000434268 http://togogenome.org/gene/83332:Rv2719c ^@ http://purl.uniprot.org/uniprot/I6YA32 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Cell wall hydrolase ChiZ|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000448834 http://togogenome.org/gene/83332:Rv3559c ^@ http://purl.uniprot.org/uniprot/I6YCF0 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA reductase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000452309 http://togogenome.org/gene/83332:Rv3920c ^@ http://purl.uniprot.org/uniprot/O53598 ^@ Region ^@ Domain Extent ^@ R3H ^@ http://togogenome.org/gene/83332:Rv0788 ^@ http://purl.uniprot.org/uniprot/P9WHL5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Glutamine amidotransferase type-1|||Nucleophile|||Phosphoribosylformylglycinamidine synthase subunit PurQ ^@ http://purl.uniprot.org/annotation/PRO_0000100572 http://togogenome.org/gene/83332:Rv2021c ^@ http://purl.uniprot.org/uniprot/O53467 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand|||Turn ^@ H-T-H motif|||HTH cro/C1-type|||Putative antitoxin HigA2 ^@ http://purl.uniprot.org/annotation/PRO_0000432911 http://togogenome.org/gene/83332:Rv3740c ^@ http://purl.uniprot.org/uniprot/P9WKA5 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv3740c ^@ http://purl.uniprot.org/annotation/PRO_0000222923 http://togogenome.org/gene/83332:Rv3375 ^@ http://purl.uniprot.org/uniprot/P9WQ93 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-ester intermediate|||Charge relay system|||Putative amidase AmiD ^@ http://purl.uniprot.org/annotation/PRO_0000105260 http://togogenome.org/gene/83332:Rv1451 ^@ http://purl.uniprot.org/uniprot/P9WFR7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Protoheme IX farnesyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000327090 http://togogenome.org/gene/83332:Rv1416 ^@ http://purl.uniprot.org/uniprot/P9WHE9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand ^@ 6,7-dimethyl-8-ribityllumazine synthase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000134772 http://togogenome.org/gene/83332:Rv2368c ^@ http://purl.uniprot.org/uniprot/P9WIA3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ PhoH-like protein ^@ http://purl.uniprot.org/annotation/PRO_0000201158 http://togogenome.org/gene/83332:Rv2273 ^@ http://purl.uniprot.org/uniprot/P9WLF3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2273 ^@ http://purl.uniprot.org/annotation/PRO_0000104001 http://togogenome.org/gene/83332:Rv0909 ^@ http://purl.uniprot.org/uniprot/P9WJ07 ^@ Molecule Processing ^@ Chain ^@ Antitoxin Rv0909 ^@ http://purl.uniprot.org/annotation/PRO_0000406886 http://togogenome.org/gene/83332:Rv0386 ^@ http://purl.uniprot.org/uniprot/O53720 ^@ Region ^@ Domain Extent ^@ Guanylate cyclase|||HTH luxR-type ^@ http://togogenome.org/gene/83332:Rv1248c ^@ http://purl.uniprot.org/uniprot/P9WIS5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Coiled-Coil ^@ Multifunctional 2-oxoglutarate metabolism enzyme|||Proton acceptor; for succinyltransferase activity ^@ http://purl.uniprot.org/annotation/PRO_0000310722 http://togogenome.org/gene/83332:Rv0730 ^@ http://purl.uniprot.org/uniprot/I6XW38 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv2941 ^@ http://purl.uniprot.org/uniprot/P9WQ59 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Long-chain-fatty-acid--AMP ligase FadD28|||No activity with lauric acid (C12 fatty acid) as substrate. Instead, it catalyzes activation of acetic acid (C2 fatty acid) as acetyl-AMP.|||Shows substantial decrease (69%) in the activity with lauric acid (C12 fatty acid) as substrate but shows a 4-fold higher activity with the long chain fatty acyl capric acid (C10 fatty acid) as substrate. ^@ http://purl.uniprot.org/annotation/PRO_0000406355 http://togogenome.org/gene/83332:Rv1059 ^@ http://purl.uniprot.org/uniprot/O53407 ^@ Region ^@ Domain Extent ^@ DAP_DH_C|||DapB_N ^@ http://togogenome.org/gene/83332:Rv0697 ^@ http://purl.uniprot.org/uniprot/I6Y8H4 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ GMC_OxRdtase_N|||GMC_oxred_C ^@ http://togogenome.org/gene/83332:Rv0881 ^@ http://purl.uniprot.org/uniprot/P9WFY3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized tRNA/rRNA methyltransferase Rv0881 ^@ http://purl.uniprot.org/annotation/PRO_0000159838 http://togogenome.org/gene/83332:Rv3623 ^@ http://purl.uniprot.org/uniprot/I6X7X3 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010310468 http://togogenome.org/gene/83332:Rv1707 ^@ http://purl.uniprot.org/uniprot/O33206 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||STAS ^@ http://togogenome.org/gene/83332:Rv1357c ^@ http://purl.uniprot.org/uniprot/P9WM07 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ EAL|||Helical|||Uncharacterized protein Rv1357c ^@ http://purl.uniprot.org/annotation/PRO_0000103828 http://togogenome.org/gene/83332:Rv3056 ^@ http://purl.uniprot.org/uniprot/P9WNT1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ DNA polymerase IV 2|||UmuC ^@ http://purl.uniprot.org/annotation/PRO_0000173926 http://togogenome.org/gene/83332:Rv2031c ^@ http://purl.uniprot.org/uniprot/P9WMK1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Crosslink|||Domain Extent|||Initiator Methionine|||Mass ^@ Alpha-crystallin|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Removed|||sHSP ^@ http://purl.uniprot.org/annotation/PRO_0000126011 http://togogenome.org/gene/83332:Rv2370c ^@ http://purl.uniprot.org/uniprot/O05828 ^@ Region ^@ Domain Extent ^@ GGDEF_2|||HTH_30 ^@ http://togogenome.org/gene/83332:Rv2891 ^@ http://purl.uniprot.org/uniprot/P9WL33 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2891 ^@ http://purl.uniprot.org/annotation/PRO_0000014147 http://togogenome.org/gene/83332:Rv1002c ^@ http://purl.uniprot.org/uniprot/P9WN05 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||Helical|||Loss of protein mannosyltransferase.|||Probable dolichyl-phosphate-mannose--protein mannosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000121517 http://togogenome.org/gene/83332:Rv2601 ^@ http://purl.uniprot.org/uniprot/P9WGE5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ Helical|||PABS|||Polyamine aminopropyltransferase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000156488 http://togogenome.org/gene/83332:Rv0098 ^@ http://purl.uniprot.org/uniprot/P9WM67 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Decrease in activity.|||Long-chain fatty acyl-CoA thioesterase FcoT|||Loss of activity. ^@ http://purl.uniprot.org/annotation/PRO_0000103668 http://togogenome.org/gene/83332:Rv3879c ^@ http://purl.uniprot.org/uniprot/P9WJC1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ ESX-1 secretion-associated protein EspK|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000394149 http://togogenome.org/gene/83332:Rv0398c ^@ http://purl.uniprot.org/uniprot/P95206 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010244969 http://togogenome.org/gene/83332:Rv3526 ^@ http://purl.uniprot.org/uniprot/P71875 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ 3-ketosteroid-9-alpha-monooxygenase, oxygenase component|||Rieske ^@ http://purl.uniprot.org/annotation/PRO_0000404098 http://togogenome.org/gene/83332:Rv0757 ^@ http://purl.uniprot.org/uniprot/P71814 ^@ Modification|||Region|||Site ^@ Binding Site|||DNA Binding|||Domain Extent|||Modified Residue ^@ 4-aspartylphosphate|||OmpR/PhoB-type|||Response regulatory ^@ http://togogenome.org/gene/83332:Rv0574c ^@ http://purl.uniprot.org/uniprot/P9WM79 ^@ Molecule Processing ^@ Chain ^@ Probable polyglutamine synthesis accessory protein Rv0574c ^@ http://purl.uniprot.org/annotation/PRO_0000392686 http://togogenome.org/gene/83332:Rv3709c ^@ http://purl.uniprot.org/uniprot/P9WPX3 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Sequence Conflict|||Splice Variant|||Strand|||Turn ^@ ACT 1|||ACT 2|||Aspartokinase|||In isoform Beta. ^@ http://purl.uniprot.org/annotation/PRO_0000002385|||http://purl.uniprot.org/annotation/VSP_018663 http://togogenome.org/gene/83332:Rv0218 ^@ http://purl.uniprot.org/uniprot/P96400 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Oxidored_molyb ^@ http://togogenome.org/gene/83332:Rv1406 ^@ http://purl.uniprot.org/uniprot/P9WND3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Methionyl-tRNA formyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000083000 http://togogenome.org/gene/83332:Rv1760 ^@ http://purl.uniprot.org/uniprot/P9WKB9 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv1760 ^@ http://purl.uniprot.org/annotation/PRO_0000222909 http://togogenome.org/gene/83332:Rv3151 ^@ http://purl.uniprot.org/uniprot/P9WIV9 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ 2Fe-2S ferredoxin-type|||4Fe-4S His(Cys)3-ligated-type|||4Fe-4S Mo/W bis-MGD-type|||N-acetylthreonine|||NADH-quinone oxidoreductase subunit G|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000118559 http://togogenome.org/gene/83332:Rv0402c ^@ http://purl.uniprot.org/uniprot/P9WJV9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport protein MmpL1 ^@ http://purl.uniprot.org/annotation/PRO_0000103562 http://togogenome.org/gene/83332:Rv2587c ^@ http://purl.uniprot.org/uniprot/P9WGP1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||Protein translocase subunit SecD ^@ http://purl.uniprot.org/annotation/PRO_0000095966 http://togogenome.org/gene/83332:Rv2060 ^@ http://purl.uniprot.org/uniprot/O86339 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0237 ^@ http://purl.uniprot.org/uniprot/L7N6B0 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Lipid Binding|||Signal Peptide|||Strand|||Turn ^@ Beta-hexosaminidase LpqI|||N-palmitoyl cysteine|||Nucleophile|||Proton donor/acceptor|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_5010230425 http://togogenome.org/gene/83332:Rv2552c ^@ http://purl.uniprot.org/uniprot/I6Y120 ^@ Region ^@ Domain Extent ^@ SDH_C|||Shikimate_dh_N ^@ http://togogenome.org/gene/83332:Rv0130 ^@ http://purl.uniprot.org/uniprot/P9WNP3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 27% loss of activity.|||3-hydroxyacyl-thioester dehydratase Z|||MaoC-like|||Total loss of activity.|||in homodimeric partner ^@ http://purl.uniprot.org/annotation/PRO_0000262761 http://togogenome.org/gene/83332:Rv2729c ^@ http://purl.uniprot.org/uniprot/O33234 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2381c ^@ http://purl.uniprot.org/uniprot/P71719 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv3570c ^@ http://purl.uniprot.org/uniprot/P9WJA1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Flavin-dependent monooxygenase, oxygenase subunit HsaA ^@ http://purl.uniprot.org/annotation/PRO_0000404501 http://togogenome.org/gene/83332:Rv0801 ^@ http://purl.uniprot.org/uniprot/O06633 ^@ Region ^@ Domain Extent ^@ VOC ^@ http://togogenome.org/gene/83332:Rv2556c ^@ http://purl.uniprot.org/uniprot/P9WFP9 ^@ Molecule Processing ^@ Chain ^@ UPF0047 protein Rv2556c ^@ http://purl.uniprot.org/annotation/PRO_0000088520 http://togogenome.org/gene/83332:Rv2685 ^@ http://purl.uniprot.org/uniprot/P9WPD7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized transporter Rv2685 ^@ http://purl.uniprot.org/annotation/PRO_0000172515 http://togogenome.org/gene/83332:Rv3389c ^@ http://purl.uniprot.org/uniprot/I6YBZ8 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ 3-hydroxyacyl-thioester dehydratase Y|||MaoC-like ^@ http://purl.uniprot.org/annotation/PRO_0000448720 http://togogenome.org/gene/83332:Rv1159A ^@ http://purl.uniprot.org/uniprot/P9WI93 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylalanine|||Putative pterin-4-alpha-carbinolamine dehydratase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000063085 http://togogenome.org/gene/83332:Rv1462 ^@ http://purl.uniprot.org/uniprot/P9WFP5 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Removed|||UPF0051 protein Rv1462 ^@ http://purl.uniprot.org/annotation/PRO_0000147386 http://togogenome.org/gene/83332:Rv0921 ^@ http://purl.uniprot.org/uniprot/I6WZS4 ^@ Region ^@ Domain Extent ^@ Resolvase/invertase-type recombinase catalytic ^@ http://togogenome.org/gene/83332:Rv1773c ^@ http://purl.uniprot.org/uniprot/O06806 ^@ Region ^@ Domain Extent ^@ HTH iclR-type|||IclR-ED ^@ http://togogenome.org/gene/83332:Rv2951c ^@ http://purl.uniprot.org/uniprot/P9WIB7 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase ^@ http://purl.uniprot.org/annotation/PRO_0000309352 http://togogenome.org/gene/83332:Rv0743c ^@ http://purl.uniprot.org/uniprot/I6WZ83 ^@ Region ^@ Domain Extent ^@ DUF6036 ^@ http://togogenome.org/gene/83332:Rv1582c ^@ http://purl.uniprot.org/uniprot/O06608 ^@ Region ^@ Domain Extent ^@ SF3 helicase ^@ http://togogenome.org/gene/83332:Rv0545c ^@ http://purl.uniprot.org/uniprot/P9WIA7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||Probable low-affinity inorganic phosphate transporter ^@ http://purl.uniprot.org/annotation/PRO_0000080792 http://togogenome.org/gene/83332:Rv3633 ^@ http://purl.uniprot.org/uniprot/P9WI89 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3633 ^@ http://purl.uniprot.org/annotation/PRO_0000215236 http://togogenome.org/gene/83332:Rv1410c ^@ http://purl.uniprot.org/uniprot/P9WJY3 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Mutagenesis Site|||Transmembrane ^@ Decreases resistance to ethidium bromide, tested in M.smegmatis.|||Helical|||Probable triacylglyceride transporter Rv1410c|||Susceptible to ethidium bromide, tested in M.smegmatis. ^@ http://purl.uniprot.org/annotation/PRO_0000391006 http://togogenome.org/gene/83332:Rv1371 ^@ http://purl.uniprot.org/uniprot/P71799 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Cytochrome b5 heme-binding|||Helical ^@ http://togogenome.org/gene/83332:Rv3067 ^@ http://purl.uniprot.org/uniprot/I6YB21 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv3067 ^@ http://purl.uniprot.org/annotation/PRO_0000432520 http://togogenome.org/gene/83332:Rv1547 ^@ http://purl.uniprot.org/uniprot/P9WNT7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ DNA polymerase III subunit alpha ^@ http://purl.uniprot.org/annotation/PRO_0000103329 http://togogenome.org/gene/83332:Rv2041c ^@ http://purl.uniprot.org/uniprot/O53485 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5030174833 http://togogenome.org/gene/83332:Rv2902c ^@ http://purl.uniprot.org/uniprot/P9WH01 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ Polar residues|||RNase H type-2|||Ribonuclease HII ^@ http://purl.uniprot.org/annotation/PRO_0000111592 http://togogenome.org/gene/83332:Rv3218 ^@ http://purl.uniprot.org/uniprot/O05848 ^@ Region ^@ Domain Extent ^@ DAGKc ^@ http://togogenome.org/gene/83332:Rv3752c ^@ http://purl.uniprot.org/uniprot/O69719 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ CMP/dCMP-type deaminase|||Proton donor ^@ http://togogenome.org/gene/83332:Rv0946c ^@ http://purl.uniprot.org/uniprot/P9WN69 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Decrease in activity.|||Glucose-6-phosphate isomerase|||Loss of activity.|||N-acetylthreonine|||Proton donor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000180677 http://togogenome.org/gene/83332:Rv0441c ^@ http://purl.uniprot.org/uniprot/P9WKW3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0441c ^@ http://purl.uniprot.org/annotation/PRO_0000103678 http://togogenome.org/gene/83332:Rv3574 ^@ http://purl.uniprot.org/uniprot/P96856 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand ^@ H-T-H motif|||HTH tetR-type|||HTH-type transcriptional repressor KstR ^@ http://purl.uniprot.org/annotation/PRO_0000405028 http://togogenome.org/gene/83332:Rv3889c ^@ http://purl.uniprot.org/uniprot/P9WJC9 ^@ Molecule Processing ^@ Chain ^@ ESX-2 secretion-associated protein EspG2 ^@ http://purl.uniprot.org/annotation/PRO_0000394153 http://togogenome.org/gene/83332:Rv0408 ^@ http://purl.uniprot.org/uniprot/P9WHP1 ^@ Molecule Processing ^@ Chain ^@ Phosphate acetyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000179135 http://togogenome.org/gene/83332:Rv3540c ^@ http://purl.uniprot.org/uniprot/I6Y3T7 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase|||Loss of activity.|||No change in activity.|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000452243 http://togogenome.org/gene/83332:Rv0768 ^@ http://purl.uniprot.org/uniprot/I6X9R9 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Aldedh ^@ http://togogenome.org/gene/83332:Rv1955 ^@ http://purl.uniprot.org/uniprot/P9WJA5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Probable endoribonuclease HigB1 ^@ http://purl.uniprot.org/annotation/PRO_0000407370 http://togogenome.org/gene/83332:Rv0585c ^@ http://purl.uniprot.org/uniprot/O53781 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3719 ^@ http://purl.uniprot.org/uniprot/O69686 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv0228 ^@ http://purl.uniprot.org/uniprot/P96410 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Acyl_transf_3|||Helical ^@ http://togogenome.org/gene/83332:Rv3162c ^@ http://purl.uniprot.org/uniprot/O53312 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0412c ^@ http://purl.uniprot.org/uniprot/P96258 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1071c ^@ http://purl.uniprot.org/uniprot/O53419 ^@ Region ^@ Domain Extent ^@ ECH_2 ^@ http://togogenome.org/gene/83332:Rv1789 ^@ http://purl.uniprot.org/uniprot/Q79FK6 ^@ Molecule Processing ^@ Chain ^@ PPE family protein PPE26 ^@ http://purl.uniprot.org/annotation/PRO_0000437938 http://togogenome.org/gene/83332:Rv0891c ^@ http://purl.uniprot.org/uniprot/P9WMV1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Guanylate cyclase|||Uncharacterized protein Rv0891c ^@ http://purl.uniprot.org/annotation/PRO_0000074130 http://togogenome.org/gene/83332:Rv2598 ^@ http://purl.uniprot.org/uniprot/P9WL71 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2598 ^@ http://purl.uniprot.org/annotation/PRO_0000104067 http://togogenome.org/gene/83332:Rv2071c ^@ http://purl.uniprot.org/uniprot/P9WGB1 ^@ Molecule Processing ^@ Chain ^@ Precorrin-4 C(11)-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000150396 http://togogenome.org/gene/83332:Rv3838c ^@ http://purl.uniprot.org/uniprot/P9WIC3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ ACT|||Prephenate dehydratase ^@ http://purl.uniprot.org/annotation/PRO_0000382029 http://togogenome.org/gene/83332:Rv0702 ^@ http://purl.uniprot.org/uniprot/P9WH85 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L4 ^@ http://purl.uniprot.org/annotation/PRO_0000129247 http://togogenome.org/gene/83332:Rv0286 ^@ http://purl.uniprot.org/uniprot/P9WI43 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Strand|||Transmembrane ^@ Helical|||PPE family protein PPE4 ^@ http://purl.uniprot.org/annotation/PRO_0000378475 http://togogenome.org/gene/83332:Rv2923c ^@ http://purl.uniprot.org/uniprot/P9WL19 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2923c ^@ http://purl.uniprot.org/annotation/PRO_0000104104 http://togogenome.org/gene/83332:Rv1903 ^@ http://purl.uniprot.org/uniprot/O07729 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1559 ^@ http://purl.uniprot.org/uniprot/P9WG95 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ ACT-like|||L-threonine dehydratase biosynthetic IlvA|||N-acetylserine|||N6-(pyridoxal phosphate)lysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000185577 http://togogenome.org/gene/83332:Rv2739c ^@ http://purl.uniprot.org/uniprot/O33282 ^@ Region ^@ Domain Extent ^@ Glyco_tran_28_C ^@ http://togogenome.org/gene/83332:Rv2568c ^@ http://purl.uniprot.org/uniprot/P9WL95 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2568c ^@ http://purl.uniprot.org/annotation/PRO_0000104045 http://togogenome.org/gene/83332:Rv3405c ^@ http://purl.uniprot.org/uniprot/P9WMC3 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Mutagenesis Site ^@ Abolishes DNA-binding and repressor activity; when associated with A-52 and A-57.|||Abolishes DNA-binding and repressor activity; when associated with A-52 and A-62.|||Abolishes DNA-binding and repressor activity; when associated with A-57 and A-62.|||H-T-H motif|||HTH tetR-type|||HTH-type transcriptional repressor Rv3405c ^@ http://purl.uniprot.org/annotation/PRO_0000070672 http://togogenome.org/gene/83332:Rv3037c ^@ http://purl.uniprot.org/uniprot/P9WJZ3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized S-adenosylmethionine-dependent methyltransferase Rv3037c ^@ http://purl.uniprot.org/annotation/PRO_0000413013 http://togogenome.org/gene/83332:Rv0291 ^@ http://purl.uniprot.org/uniprot/O53695 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Charge relay system|||Helical|||Mycosin-3|||Peptidase S8 ^@ http://purl.uniprot.org/annotation/PRO_5007697062 http://togogenome.org/gene/83332:Rv1474c ^@ http://purl.uniprot.org/uniprot/O53165 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Mutagenesis Site ^@ Cannot bind DNA; when associated with A-45 and A-50.|||Cannot bind DNA; when associated with A-45 and A-55.|||Cannot bind DNA; when associated with A-50 and A-55.|||H-T-H motif|||HTH tetR-type|||HTH-type transcriptional repressor Rv1474c ^@ http://purl.uniprot.org/annotation/PRO_0000447327 http://togogenome.org/gene/83332:Rv2860c ^@ http://purl.uniprot.org/uniprot/I6X5K1 ^@ Region ^@ Domain Extent ^@ GS beta-grasp|||GS catalytic ^@ http://togogenome.org/gene/83332:Rv0103c ^@ http://purl.uniprot.org/uniprot/P9WPT9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Cation-transporting P-type ATPase B|||HMA|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000046168 http://togogenome.org/gene/83332:Rv2490c ^@ http://purl.uniprot.org/uniprot/Q79FD4 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv0936 ^@ http://purl.uniprot.org/uniprot/P9WG09 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Phosphate transport system permease protein PstA 2 ^@ http://purl.uniprot.org/annotation/PRO_0000060203 http://togogenome.org/gene/83332:Rv2689c ^@ http://purl.uniprot.org/uniprot/O07191 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ Nucleophile|||TRAM ^@ http://togogenome.org/gene/83332:Rv1785c ^@ http://purl.uniprot.org/uniprot/P9WPL3 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Putative cytochrome P450 143|||Removed|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052306 http://togogenome.org/gene/83332:Rv1592c ^@ http://purl.uniprot.org/uniprot/P9WK89 ^@ Molecule Processing ^@ Chain ^@ Probable inactive lipase Rv1592c ^@ http://purl.uniprot.org/annotation/PRO_0000392687 http://togogenome.org/gene/83332:Rv2081c ^@ http://purl.uniprot.org/uniprot/P9WLK5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2081c ^@ http://purl.uniprot.org/annotation/PRO_0000103952 http://togogenome.org/gene/83332:Rv0555 ^@ http://purl.uniprot.org/uniprot/P9WK11 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000341784 http://togogenome.org/gene/83332:Rv1420 ^@ http://purl.uniprot.org/uniprot/P9WFC5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ GIY-YIG|||UVR|||UvrABC system protein C ^@ http://purl.uniprot.org/annotation/PRO_0000138320 http://togogenome.org/gene/83332:Rv3645 ^@ http://purl.uniprot.org/uniprot/I6X7Z3 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Guanylate cyclase|||HAMP|||Helical ^@ http://togogenome.org/gene/83332:Rv2258c ^@ http://purl.uniprot.org/uniprot/O53532 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ S-adenosylmethionine-dependent methyltransferase Rv2258c ^@ http://purl.uniprot.org/annotation/PRO_0000450837 http://togogenome.org/gene/83332:Rv1913 ^@ http://purl.uniprot.org/uniprot/O07720 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv1382 ^@ http://purl.uniprot.org/uniprot/P71810 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3078 ^@ http://purl.uniprot.org/uniprot/I6Y2H3 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2085 ^@ http://purl.uniprot.org/uniprot/P9WLJ9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2085 ^@ http://purl.uniprot.org/annotation/PRO_0000103956 http://togogenome.org/gene/83332:Rv2051c ^@ http://purl.uniprot.org/uniprot/O53493 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Topological Domain|||Transmembrane ^@ Basic and acidic residues|||Bifunctional apolipoprotein N-acyltransferase/polyprenol monophosphomannose synthase|||CN hydrolase|||Cytoplasmic|||Extracellular|||Helical|||Nucleophile|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000434582 http://togogenome.org/gene/83332:Rv2913c ^@ http://purl.uniprot.org/uniprot/P9WJH9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2913c ^@ http://purl.uniprot.org/annotation/PRO_0000182708 http://togogenome.org/gene/83332:Rv1473A ^@ http://purl.uniprot.org/uniprot/L7N691 ^@ Region ^@ Domain Extent ^@ HTH_58 ^@ http://togogenome.org/gene/83332:Rv0811c ^@ http://purl.uniprot.org/uniprot/I6X9V3 ^@ Region ^@ Domain Extent ^@ GCV_T ^@ http://togogenome.org/gene/83332:Rv0013 ^@ http://purl.uniprot.org/uniprot/P9WN35 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ Anthranilate synthase component 2|||For GATase activity|||Glutamine amidotransferase type-1|||Nucleophile; for GATase activity ^@ http://purl.uniprot.org/annotation/PRO_0000390894 http://togogenome.org/gene/83332:Rv3762c ^@ http://purl.uniprot.org/uniprot/O69728 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv2711 ^@ http://purl.uniprot.org/uniprot/P9WMH1 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ HTH dtxR-type|||Iron-dependent repressor IdeR ^@ http://purl.uniprot.org/annotation/PRO_0000201108 http://togogenome.org/gene/83332:Rv3586 ^@ http://purl.uniprot.org/uniprot/P9WNW5 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ Abolishes ATP-binding and diadenylate cyclase activity.|||DAC|||DNA integrity scanning protein DisA|||Retains diadenylate cyclase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000424180 http://togogenome.org/gene/83332:Rv0452 ^@ http://purl.uniprot.org/uniprot/O53737 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv3901c ^@ http://purl.uniprot.org/uniprot/O05444 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1677 ^@ http://purl.uniprot.org/uniprot/I6XYM2 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_5010284880 http://togogenome.org/gene/83332:Rv0778 ^@ http://purl.uniprot.org/uniprot/P9WPN9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 126|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052282 http://togogenome.org/gene/83332:Rv1124 ^@ http://purl.uniprot.org/uniprot/O06576 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv1082 ^@ http://purl.uniprot.org/uniprot/P9WJN1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Mycothiol S-conjugate amidase ^@ http://purl.uniprot.org/annotation/PRO_0000423187 http://togogenome.org/gene/83332:Rv0074 ^@ http://purl.uniprot.org/uniprot/O53619 ^@ Region ^@ Domain Extent ^@ Amidohydro-rel ^@ http://togogenome.org/gene/83332:Rv1263 ^@ http://purl.uniprot.org/uniprot/P9WQ97 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-ester intermediate|||Charge relay system|||Putative amidase AmiB2 ^@ http://purl.uniprot.org/annotation/PRO_0000105255 http://togogenome.org/gene/83332:Rv1809 ^@ http://purl.uniprot.org/uniprot/P9WI03 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE33 ^@ http://purl.uniprot.org/annotation/PRO_0000379589 http://togogenome.org/gene/83332:Rv0901 ^@ http://purl.uniprot.org/uniprot/P9WJG5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein ArfC ^@ http://purl.uniprot.org/annotation/PRO_0000103741 http://togogenome.org/gene/83332:Rv1738 ^@ http://purl.uniprot.org/uniprot/P9WLS3 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Uncharacterized protein Rv1738 ^@ http://purl.uniprot.org/annotation/PRO_0000103896 http://togogenome.org/gene/83332:Rv2610c ^@ http://purl.uniprot.org/uniprot/P9WMZ5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Phosphatidyl-myo-inositol mannosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000080302 http://togogenome.org/gene/83332:Rv0712 ^@ http://purl.uniprot.org/uniprot/I6Y8I5 ^@ Experimental Information|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Mutagenesis Site ^@ Abolished formylglycine-generating enzyme activity.|||Formylglycine-generating enzyme|||Strongly reduced formylglycine-generating enzyme activity. ^@ http://purl.uniprot.org/annotation/PRO_0000444619 http://togogenome.org/gene/83332:Rv3848 ^@ http://purl.uniprot.org/uniprot/P96229 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv1086 ^@ http://purl.uniprot.org/uniprot/P9WFF5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ (2Z,6E)-farnesyl diphosphate synthase|||4-fold decrease in affinity relative to the wild-type and able to synthesize prenyl diphosphates containing 20 and 50 carbon atoms when GPP and EE-FPP are used as the allylic substrates, respectively, whereas the wild-type enzyme generates product that is restricted to 15 carbon atoms with GPP as substrate and does not react with EE-FPP; when associated with G-107.|||No detectable activity. 4-fold decrease in affinity relative to the wild-type and able to synthesize prenyl diphosphates containing 20 and 50 carbon atoms when GPP and EE-FPP are used as the allylic substrates, respectively, whereas the wild-type enzyme generates product that is restricted to 15 carbon atoms with GPP as substrate and does not react with EE-FPP; when associated with A-84.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000123748 http://togogenome.org/gene/83332:Rv0355c ^@ http://purl.uniprot.org/uniprot/I6Y7L4 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv3266c ^@ http://purl.uniprot.org/uniprot/P9WH09 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton donor/acceptor|||dTDP-4-dehydrorhamnose reductase ^@ http://purl.uniprot.org/annotation/PRO_0000395352 http://togogenome.org/gene/83332:Rv2922A ^@ http://purl.uniprot.org/uniprot/P9WQC9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Acylphosphatase|||Acylphosphatase-like ^@ http://purl.uniprot.org/annotation/PRO_0000158556 http://togogenome.org/gene/83332:Rv3228 ^@ http://purl.uniprot.org/uniprot/O05873 ^@ Region ^@ Domain Extent ^@ CP-type G|||ENGC_GTPASE ^@ http://togogenome.org/gene/83332:Rv0477 ^@ http://purl.uniprot.org/uniprot/P9WKV9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv0477 ^@ http://purl.uniprot.org/annotation/PRO_0000014074 http://togogenome.org/gene/83332:Rv1387 ^@ http://purl.uniprot.org/uniprot/P9WI23 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Uncharacterized PPE family protein PPE20 ^@ http://purl.uniprot.org/annotation/PRO_0000379110 http://togogenome.org/gene/83332:Rv1687c ^@ http://purl.uniprot.org/uniprot/O33189 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv3912 ^@ http://purl.uniprot.org/uniprot/P9WJ65 ^@ Molecule Processing|||Region ^@ Chain|||Topological Domain|||Transmembrane ^@ Anti-sigma-M factor RsmA|||Cytoplasmic|||Extracellular|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000422684 http://togogenome.org/gene/83332:Rv1485 ^@ http://purl.uniprot.org/uniprot/P9WNE3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Coproporphyrin III ferrochelatase ^@ http://purl.uniprot.org/annotation/PRO_0000175167 http://togogenome.org/gene/83332:Rv2871 ^@ http://purl.uniprot.org/uniprot/P9WL41 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB43 ^@ http://purl.uniprot.org/annotation/PRO_0000104085 http://togogenome.org/gene/83332:Rv0115 ^@ http://purl.uniprot.org/uniprot/O53637 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ D-glycero-alpha-D-manno-heptose 7-phosphate kinase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000453019 http://togogenome.org/gene/83332:Rv3234c ^@ http://purl.uniprot.org/uniprot/P9WKC5 ^@ Molecule Processing ^@ Chain ^@ Probable diacyglycerol O-acyltransferase tgs3 ^@ http://purl.uniprot.org/annotation/PRO_0000222918 http://togogenome.org/gene/83332:Rv3742c ^@ http://purl.uniprot.org/uniprot/O69709 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2701c ^@ http://purl.uniprot.org/uniprot/P9WKI9 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Inositol-1-monophosphatase SuhB|||Less than 4% of wild-type activity.|||N-acetylthreonine|||No effect on activity. 10-fold more resistant to inhibition by Li(+).|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000142564 http://togogenome.org/gene/83332:Rv0597c ^@ http://purl.uniprot.org/uniprot/I6WYU2 ^@ Region ^@ Domain Extent ^@ AAA_14|||DUF4143 ^@ http://togogenome.org/gene/83332:Rv3545c ^@ http://purl.uniprot.org/uniprot/P9WPP1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Steroid C26-monooxygenase|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052280 http://togogenome.org/gene/83332:Rv0422c ^@ http://purl.uniprot.org/uniprot/P9WG77 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine ^@ Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000192023 http://togogenome.org/gene/83332:Rv2632c ^@ http://purl.uniprot.org/uniprot/P9WL61 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Uncharacterized protein Rv2632c ^@ http://purl.uniprot.org/annotation/PRO_0000104072 http://togogenome.org/gene/83332:Rv1603 ^@ http://purl.uniprot.org/uniprot/P9WMM5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Phosphoribosyl isomerase A|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000142085 http://togogenome.org/gene/83332:Rv2092c ^@ http://purl.uniprot.org/uniprot/P9WMR1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ DEVH box|||Helicase ATP-binding|||Helicase C-terminal|||Probable helicase HelY ^@ http://purl.uniprot.org/annotation/PRO_0000102102 http://togogenome.org/gene/83332:Rv3858c ^@ http://purl.uniprot.org/uniprot/P9WN19 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ 4Fe-4S ferredoxin-type|||Glutamate synthase [NADPH] small chain ^@ http://purl.uniprot.org/annotation/PRO_0000419546 http://togogenome.org/gene/83332:Rv2460c ^@ http://purl.uniprot.org/uniprot/P9WPC3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ ATP-dependent Clp protease proteolytic subunit 2|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000179597 http://togogenome.org/gene/83332:Rv1102c ^@ http://purl.uniprot.org/uniprot/P9WIH9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Endoribonuclease MazF3 ^@ http://purl.uniprot.org/annotation/PRO_0000406306 http://togogenome.org/gene/83332:Rv0566c ^@ http://purl.uniprot.org/uniprot/P9WFK9 ^@ Molecule Processing ^@ Chain ^@ UPF0234 protein Rv0566c ^@ http://purl.uniprot.org/annotation/PRO_0000106188 http://togogenome.org/gene/83332:Rv1431 ^@ http://purl.uniprot.org/uniprot/O06827 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3658c ^@ http://purl.uniprot.org/uniprot/I6Y479 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||T2SSF ^@ http://togogenome.org/gene/83332:Rv2270 ^@ http://purl.uniprot.org/uniprot/P9WK73 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppN|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018113 http://togogenome.org/gene/83332:Rv1925 ^@ http://purl.uniprot.org/uniprot/I6Y7V6 ^@ Region ^@ Domain Extent ^@ AMP-binding ^@ http://togogenome.org/gene/83332:Rv2096c ^@ http://purl.uniprot.org/uniprot/P9WIM1 ^@ Molecule Processing ^@ Chain ^@ Protein PafB ^@ http://purl.uniprot.org/annotation/PRO_0000103963 http://togogenome.org/gene/83332:Rv1564c ^@ http://purl.uniprot.org/uniprot/P9WQ25 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Glycogen operon protein GlgX homolog|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000054307 http://togogenome.org/gene/83332:Rv2928 ^@ http://purl.uniprot.org/uniprot/P9WQD5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Loss of activity.|||Thioesterase TesA ^@ http://purl.uniprot.org/annotation/PRO_0000180368 http://togogenome.org/gene/83332:Rv2578c ^@ http://purl.uniprot.org/uniprot/P9WL79 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ Helical|||Radical SAM core|||Uncharacterized protein Rv2578c ^@ http://purl.uniprot.org/annotation/PRO_0000104061 http://togogenome.org/gene/83332:Rv0096 ^@ http://purl.uniprot.org/uniprot/P9WI49 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized PPE family protein PPE1 ^@ http://purl.uniprot.org/annotation/PRO_0000217842 http://togogenome.org/gene/83332:Rv3772 ^@ http://purl.uniprot.org/uniprot/P9WML5 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||Putative phenylalanine aminotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000153517 http://togogenome.org/gene/83332:Rv1496 ^@ http://purl.uniprot.org/uniprot/P9WPZ1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Strand|||Turn ^@ Probable GTPase Rv1496|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000157817 http://togogenome.org/gene/83332:Rv0464c ^@ http://purl.uniprot.org/uniprot/O53749 ^@ Region ^@ Domain Extent ^@ CMD ^@ http://togogenome.org/gene/83332:Rv2721c ^@ http://purl.uniprot.org/uniprot/I6XF52 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical ^@ http://purl.uniprot.org/annotation/PRO_5010339386 http://togogenome.org/gene/83332:Rv3600c ^@ http://purl.uniprot.org/uniprot/P9WPA1 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Type III pantothenate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000267566 http://togogenome.org/gene/83332:Rv2218 ^@ http://purl.uniprot.org/uniprot/P9WK91 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Lipoyl synthase|||Radical SAM core ^@ http://purl.uniprot.org/annotation/PRO_0000102326 http://togogenome.org/gene/83332:Rv2608 ^@ http://purl.uniprot.org/uniprot/P9WHZ5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE-PPE|||Uncharacterized PPE family protein PPE42 ^@ http://purl.uniprot.org/annotation/PRO_0000379116 http://togogenome.org/gene/83332:Rv0254c ^@ http://purl.uniprot.org/uniprot/O53676 ^@ Site ^@ Active Site|||Binding Site ^@ GMP-histidine intermediate ^@ http://togogenome.org/gene/83332:Rv1613 ^@ http://purl.uniprot.org/uniprot/P9WFY1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||Tryptophan synthase alpha chain ^@ http://purl.uniprot.org/annotation/PRO_0000098811 http://togogenome.org/gene/83332:Rv1098c ^@ http://purl.uniprot.org/uniprot/P9WN93 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Absence of fumarase activity.|||Fumarate hydratase class II|||N-acetylalanine|||Proton donor/acceptor|||Removed|||in site B ^@ http://purl.uniprot.org/annotation/PRO_0000161289 http://togogenome.org/gene/83332:Rv0084 ^@ http://purl.uniprot.org/uniprot/Q10881 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1797 ^@ http://purl.uniprot.org/uniprot/P9WJE3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-5 secretion system protein EccE5|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393872 http://togogenome.org/gene/83332:Rv1273c ^@ http://purl.uniprot.org/uniprot/P9WQJ1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||ABC transporter|||Helical|||Uncharacterized ABC transporter ATP-binding protein Rv1273c ^@ http://purl.uniprot.org/annotation/PRO_0000093264 http://togogenome.org/gene/83332:Rv1442 ^@ http://purl.uniprot.org/uniprot/O06817 ^@ Region ^@ Domain Extent ^@ Molybdopterin|||Molybdopterin_N|||Molydop_binding ^@ http://togogenome.org/gene/83332:Rv0911 ^@ http://purl.uniprot.org/uniprot/I6XA34 ^@ Region ^@ Domain Extent ^@ VOC ^@ http://togogenome.org/gene/83332:Rv1748 ^@ http://purl.uniprot.org/uniprot/P72005 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2622 ^@ http://purl.uniprot.org/uniprot/I6XES4 ^@ Region ^@ Domain Extent ^@ Methyltransf_11 ^@ http://togogenome.org/gene/83332:Rv3276c ^@ http://purl.uniprot.org/uniprot/P9WHL9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ATP-grasp|||N5-carboxyaminoimidazole ribonucleotide synthase ^@ http://purl.uniprot.org/annotation/PRO_0000075000 http://togogenome.org/gene/83332:Rv2421c ^@ http://purl.uniprot.org/uniprot/P9WJJ5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Probable nicotinate-nucleotide adenylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000181427 http://togogenome.org/gene/83332:Rv1390 ^@ http://purl.uniprot.org/uniprot/P9WGY5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ DNA-directed RNA polymerase subunit omega ^@ http://purl.uniprot.org/annotation/PRO_0000128952 http://togogenome.org/gene/83332:Rv0487 ^@ http://purl.uniprot.org/uniprot/P9WKU9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0487 ^@ http://purl.uniprot.org/annotation/PRO_0000103689 http://togogenome.org/gene/83332:Rv2239c ^@ http://purl.uniprot.org/uniprot/P9WLG9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2239c ^@ http://purl.uniprot.org/annotation/PRO_0000103987 http://togogenome.org/gene/83332:Rv3427c ^@ http://purl.uniprot.org/uniprot/Q50701 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative ATP-binding protein Rv3427c in insertion sequence ^@ http://purl.uniprot.org/annotation/PRO_0000075481 http://togogenome.org/gene/83332:Rv0315 ^@ http://purl.uniprot.org/uniprot/O07242 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Signal Peptide ^@ GH16 ^@ http://purl.uniprot.org/annotation/PRO_5010335828 http://togogenome.org/gene/83332:Rv3923c ^@ http://purl.uniprot.org/uniprot/P9WGZ3 ^@ Molecule Processing ^@ Chain ^@ Ribonuclease P protein component ^@ http://purl.uniprot.org/annotation/PRO_0000198494 http://togogenome.org/gene/83332:Rv1697 ^@ http://purl.uniprot.org/uniprot/O33198 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||TPPK_C ^@ http://togogenome.org/gene/83332:Rv3246c ^@ http://purl.uniprot.org/uniprot/P9WGM7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||DNA Binding|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 4-aspartylphosphate|||DNA-binding response regulator MtrA|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||No phosphorylation by EnvZ kinase in vitro, does not bind DNA. Poor growth in infected macrophages and upon mouse infection. Fewer bacteria are mistargeted to lysosomes.|||No phosphorylation by EnvZ kinase in vitro. Binds DNA in the absence but not presence of EnvZ and ATP. A merodiploid strain has late growth defects. May mimic the phosphorylated state.|||No phosphorylation by EnvZ kinase in vitro. Binds fbpB and oriC DNA in the presence and absence of EnvZ and ATP. A merodiploid strain has late growth defects, fbpB is down-regulated. May be constitutively active.|||OmpR/PhoB-type|||Phosphorylated by EnvZ kinase in vitro, reverses many phenotypes of mtrB knockout.|||Response regulatory ^@ http://purl.uniprot.org/annotation/PRO_0000081143 http://togogenome.org/gene/83332:Rv3754 ^@ http://purl.uniprot.org/uniprot/O69721 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Prephenate dehydrogenase|||Prephenate/arogenate dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000432509 http://togogenome.org/gene/83332:Rv0608 ^@ http://purl.uniprot.org/uniprot/P9WJ39 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB28 ^@ http://purl.uniprot.org/annotation/PRO_0000408072 http://togogenome.org/gene/83332:Rv2366c ^@ http://purl.uniprot.org/uniprot/P9WFP1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ CBS 1|||CBS 2|||CNNM transmembrane|||Helical|||UPF0053 protein Rv2366c ^@ http://purl.uniprot.org/annotation/PRO_0000088381 http://togogenome.org/gene/83332:Rv0785 ^@ http://purl.uniprot.org/uniprot/P71838 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ KsdD-like steroid dehydrogenase Rv0785 ^@ http://purl.uniprot.org/annotation/PRO_0000403955 http://togogenome.org/gene/83332:Rv0432 ^@ http://purl.uniprot.org/uniprot/P9WGE9 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Disulfide Bond|||Helix|||Lipid Binding|||Signal Peptide|||Strand|||Turn ^@ N-palmitoyl cysteine|||Polar residues|||S-diacylglycerol cysteine|||Superoxide dismutase [Cu-Zn] ^@ http://purl.uniprot.org/annotation/PRO_0000032840 http://togogenome.org/gene/83332:Rv1283c ^@ http://purl.uniprot.org/uniprot/P9WFZ7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Putative peptide transport permease protein Rv1283c ^@ http://purl.uniprot.org/annotation/PRO_0000060291 http://togogenome.org/gene/83332:Rv0244c ^@ http://purl.uniprot.org/uniprot/O53666 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Broad-specificity linear acyl-CoA dehydrogenase FadE5|||Decreases affinity for eicosanoyl-CoA; when associated with A-447.|||Increases affinity for eicosanoyl-CoA; when associated with A-447.|||Loss of activity.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000452498 http://togogenome.org/gene/83332:Rv3371 ^@ http://purl.uniprot.org/uniprot/P9WKA9 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv3371 ^@ http://purl.uniprot.org/annotation/PRO_0000222919 http://togogenome.org/gene/83332:Rv3868 ^@ http://purl.uniprot.org/uniprot/P9WPH9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Decrease in substrate-binding and in catalytic efficiency.|||Does not affect substrate-binding, but decreases the catalytic efficiency and the Vmax.|||Does not distord the binding site architecture. No change in catalytic efficiency and Vmax.|||ESX-1 secretion system protein EccA1|||Large increase in the Km and strong decrease in catalytic efficiency. Loses the ability to self-associate in the presence of ATP and the cooperativity is nearly abolished. ^@ http://purl.uniprot.org/annotation/PRO_0000063049 http://togogenome.org/gene/83332:Rv1115 ^@ http://purl.uniprot.org/uniprot/O06567 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0576 ^@ http://purl.uniprot.org/uniprot/O53773 ^@ Region ^@ Domain Extent ^@ HTH arsR-type ^@ http://togogenome.org/gene/83332:Rv2283 ^@ http://purl.uniprot.org/uniprot/P9WLE9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2283 ^@ http://purl.uniprot.org/annotation/PRO_0000104004 http://togogenome.org/gene/83332:Rv3398c ^@ http://purl.uniprot.org/uniprot/P9WKH1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ (2E,6E)-farnesyl diphosphate synthase|||DDXXD motif ^@ http://purl.uniprot.org/annotation/PRO_0000123968 http://togogenome.org/gene/83332:Rv0469 ^@ http://purl.uniprot.org/uniprot/Q6MX39 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ S-adenosylmethionine-dependent methyltransferase UmaA ^@ http://purl.uniprot.org/annotation/PRO_0000434597 http://togogenome.org/gene/83332:Rv1403c ^@ http://purl.uniprot.org/uniprot/P9WLY9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1403c ^@ http://purl.uniprot.org/annotation/PRO_0000014101 http://togogenome.org/gene/83332:Rv0008c ^@ http://purl.uniprot.org/uniprot/P9WJF3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Cell wall synthesis protein CwsA|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000103640 http://togogenome.org/gene/83332:Rv2938 ^@ http://purl.uniprot.org/uniprot/P9WG21 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-2|||Helical|||Probable doxorubicin resistance ABC transporter permease protein DrrC ^@ http://purl.uniprot.org/annotation/PRO_0000393227 http://togogenome.org/gene/83332:Rv2589 ^@ http://purl.uniprot.org/uniprot/P9WQ79 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ 4-aminobutyrate aminotransferase|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000120386 http://togogenome.org/gene/83332:Rv3439c ^@ http://purl.uniprot.org/uniprot/I6YC49 ^@ Region ^@ Compositionally Biased Region ^@ Acidic residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv3783 ^@ http://purl.uniprot.org/uniprot/P72049 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC2_membrane|||Helical ^@ http://togogenome.org/gene/83332:Rv1234 ^@ http://purl.uniprot.org/uniprot/O50451 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||YflT ^@ http://togogenome.org/gene/83332:Rv2411c ^@ http://purl.uniprot.org/uniprot/P9WLA9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Polar residues|||Uncharacterized protein Rv2411c ^@ http://purl.uniprot.org/annotation/PRO_0000104032 http://togogenome.org/gene/83332:Rv2767c ^@ http://purl.uniprot.org/uniprot/O33309 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2731 ^@ http://purl.uniprot.org/uniprot/I6XF60 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues|||Polar residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2228c ^@ http://purl.uniprot.org/uniprot/P9WLH5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ Bifunctional protein Rv2228c|||Proton donor/acceptor; for phosphatase activity|||RNase H type-1|||Tele-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000103981 http://togogenome.org/gene/83332:Rv3097c ^@ http://purl.uniprot.org/uniprot/I6Y2J4 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Motif ^@ Cytosolic triacylglycerol lipase|||Extracellular triacylglycerol lipase|||Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole|||PE ^@ http://purl.uniprot.org/annotation/PRO_0000438268|||http://purl.uniprot.org/annotation/PRO_0000449879 http://togogenome.org/gene/83332:Rv0126 ^@ http://purl.uniprot.org/uniprot/P9WQ19 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Nucleophile|||Proton donor|||Trehalose synthase/amylase TreS ^@ http://purl.uniprot.org/annotation/PRO_0000412906 http://togogenome.org/gene/83332:Rv2692 ^@ http://purl.uniprot.org/uniprot/P9WFZ3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ RCK C-terminal|||RCK N-terminal|||Trk system potassium uptake protein TrkA|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000148720 http://togogenome.org/gene/83332:Rv2169c ^@ http://purl.uniprot.org/uniprot/O53503 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0268c ^@ http://purl.uniprot.org/uniprot/P95225 ^@ Molecule Processing|||Region ^@ Chain|||Coiled-Coil|||Compositionally Biased Region ^@ Polar residues|||Putative antitoxin Rv0268c ^@ http://purl.uniprot.org/annotation/PRO_0000434894 http://togogenome.org/gene/83332:Rv1624c ^@ http://purl.uniprot.org/uniprot/O06141 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3385c ^@ http://purl.uniprot.org/uniprot/P9WF13 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB46 ^@ http://purl.uniprot.org/annotation/PRO_0000408050 http://togogenome.org/gene/83332:Rv0625c ^@ http://purl.uniprot.org/uniprot/P9WFS5 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ Helical|||N-acetylserine|||Removed|||TVP38/TMEM64 family membrane protein Rv0625c ^@ http://purl.uniprot.org/annotation/PRO_0000198636 http://togogenome.org/gene/83332:Rv0094c ^@ http://purl.uniprot.org/uniprot/Q50655 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||HNHc ^@ http://togogenome.org/gene/83332:Rv1815 ^@ http://purl.uniprot.org/uniprot/P9WLR9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1815 ^@ http://purl.uniprot.org/annotation/PRO_0000014109 http://togogenome.org/gene/83332:Rv1454c ^@ http://purl.uniprot.org/uniprot/O53146 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv0587 ^@ http://purl.uniprot.org/uniprot/I6Y870 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1594 ^@ http://purl.uniprot.org/uniprot/P9WJK1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Quinolinate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000155791 http://togogenome.org/gene/83332:Rv2112c ^@ http://purl.uniprot.org/uniprot/P9WNU9 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ Abolishes pupylation and depupylase activity.|||Abolishes pupylation.|||Proton acceptor|||Pup deamidase/depupylase ^@ http://purl.uniprot.org/annotation/PRO_0000383480 http://togogenome.org/gene/83332:Rv2433c ^@ http://purl.uniprot.org/uniprot/P71916 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3286c ^@ http://purl.uniprot.org/uniprot/P9WGI3 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Motif|||Sequence Conflict ^@ H-T-H motif|||Interaction with polymerase core subunit RpoC|||RNA polymerase sigma factor SigF ^@ http://purl.uniprot.org/annotation/PRO_0000422954 http://togogenome.org/gene/83332:Rv0214 ^@ http://purl.uniprot.org/uniprot/P96396 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv2249c ^@ http://purl.uniprot.org/uniprot/P9WN81 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Glycerol-3-phosphate dehydrogenase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000126100 http://togogenome.org/gene/83332:Rv0160c ^@ http://purl.uniprot.org/uniprot/L7N661 ^@ Region ^@ Domain Extent ^@ PE|||PE-PPE ^@ http://togogenome.org/gene/83332:Rv0888 ^@ http://purl.uniprot.org/uniprot/P9WKQ1 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Mutagenesis Site|||Signal Peptide|||Topological Domain|||Transmembrane ^@ Beta stranded|||Extracellular|||Loss of catalytic activity but still able to mediate uptake of glucose and phosphocholine; when associated with N-353.|||Loss of catalytic activity but still able to mediate uptake of glucose and phosphocholine; when associated with N-481.|||Periplasmic|||Polar residues|||Sphingomyelinase ^@ http://purl.uniprot.org/annotation/PRO_0000103731 http://togogenome.org/gene/83332:Rv2068c ^@ http://purl.uniprot.org/uniprot/P9WKD3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ 200000-fold decrease in catalytic efficiency with cefamandole as substrate.|||Acyl-ester intermediate|||Beta-lactamase|||Loss of catalytic activity with cefamandole as substrate.|||No longer exported via the Tat-system. Loss of cell resistance to beta-lactam antibiotics.|||Only minor impairment of catalytic activity with both nitrocefin and ampicillin. Still inhibited by clavulanate and carbapenems.|||Proton acceptor|||Significant increase in ampicillin resistance. 2-fold and 3-fold increase in catalytic efficiency with ampicillin and nitrocefin as substrate, respectively, mainly due to an increase in substrate affinity.|||Significant reduction of catalytic activity for both nitrocefin and ampicillin. Leads to in vitro clavulanate resistance and decreased susceptibility to carbapenem inhibitors, but is still susceptible to ampicillin-clavulanate in vivo.|||Significant reduction of catalytic activity for both nitrocefin and ampicillin. Only minor impairment of the inactivation by clavulanate. Larger increase in resistance to carbapenems.|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000017005 http://togogenome.org/gene/83332:Rv3625c ^@ http://purl.uniprot.org/uniprot/P9WG53 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ tRNA(Ile)-lysidine synthase ^@ http://purl.uniprot.org/annotation/PRO_0000181725 http://togogenome.org/gene/83332:Rv1646 ^@ http://purl.uniprot.org/uniprot/L7N681 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv1158c ^@ http://purl.uniprot.org/uniprot/O06556 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010284889 http://togogenome.org/gene/83332:Rv0621 ^@ http://purl.uniprot.org/uniprot/I6X9F4 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2378c ^@ http://purl.uniprot.org/uniprot/P9WKF7 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ L-lysine N6-monooxygenase MbtG ^@ http://purl.uniprot.org/annotation/PRO_0000261312 http://togogenome.org/gene/83332:Rv3567c ^@ http://purl.uniprot.org/uniprot/P9WND9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Flavin-dependent monooxygenase, reductase subunit HsaB ^@ http://purl.uniprot.org/annotation/PRO_0000404505 http://togogenome.org/gene/83332:Rv0798c ^@ http://purl.uniprot.org/uniprot/I6WZG6 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Initiator Methionine|||Sequence Conflict ^@ Removed; alternate|||Type 1 encapsulin shell protein|||Type 1 encapsulin shell protein, N-terminally processed ^@ http://purl.uniprot.org/annotation/PRO_0000455313|||http://purl.uniprot.org/annotation/PRO_0000455314 http://togogenome.org/gene/83332:Rv0444c ^@ http://purl.uniprot.org/uniprot/P9WGX5 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Topological Domain|||Transmembrane ^@ Anti-sigma-K factor RskA|||Cytoplasmic|||Extracellular|||Helical|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000313835 http://togogenome.org/gene/83332:Rv1293 ^@ http://purl.uniprot.org/uniprot/P9WIU7 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond|||Helix|||Modified Residue|||Sequence Conflict|||Strand|||Turn ^@ Diaminopimelate decarboxylase|||Interchain (with C-375)|||Interchain (with C-72)|||N6-(pyridoxal phosphate)lysine|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000149929 http://togogenome.org/gene/83332:Rv3034c ^@ http://purl.uniprot.org/uniprot/O53281 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Probable acetyltransferase Rv3034c ^@ http://purl.uniprot.org/annotation/PRO_0000413012 http://togogenome.org/gene/83332:Rv3917c ^@ http://purl.uniprot.org/uniprot/P9WIJ9 ^@ Molecule Processing ^@ Chain ^@ Probable chromosome-partitioning protein ParB ^@ http://purl.uniprot.org/annotation/PRO_0000178685 http://togogenome.org/gene/83332:Rv3881c ^@ http://purl.uniprot.org/uniprot/P9WJD9 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand ^@ ESX-1 secretion-associated protein EspB|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000096612 http://togogenome.org/gene/83332:Rv3508 ^@ http://purl.uniprot.org/uniprot/O53553 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||Uncharacterized PE-PGRS family protein PE_PGRS54 ^@ http://purl.uniprot.org/annotation/PRO_0000023578 http://togogenome.org/gene/83332:Rv1952 ^@ http://purl.uniprot.org/uniprot/P95262 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB14 ^@ http://purl.uniprot.org/annotation/PRO_0000408061 http://togogenome.org/gene/83332:Rv1413 ^@ http://purl.uniprot.org/uniprot/P9WLY5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1413 ^@ http://purl.uniprot.org/annotation/PRO_0000103839 http://togogenome.org/gene/83332:Rv0019c ^@ http://purl.uniprot.org/uniprot/P9WJB5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Transmembrane ^@ Does not affect phosphorylation.|||FHA|||FHA domain-containing protein FhaB|||Helical|||Impairs interaction with PknB and PapA5.|||Impairs interaction with PknB. Does not affect interaction with PapA5.|||Lack of phosphorylation.|||Phosphothreonine; by PknB ^@ http://purl.uniprot.org/annotation/PRO_0000419671 http://togogenome.org/gene/83332:Rv1770 ^@ http://purl.uniprot.org/uniprot/O06803 ^@ Region ^@ Domain Extent ^@ Peptidase_M28 ^@ http://togogenome.org/gene/83332:Rv2948c ^@ http://purl.uniprot.org/uniprot/P9WQ61 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue ^@ Carrier|||O-(pantetheine 4'-phosphoryl)serine|||p-hydroxybenzoic acid--AMP ligase FadD22 ^@ http://purl.uniprot.org/annotation/PRO_0000406350 http://togogenome.org/gene/83332:Rv2600 ^@ http://purl.uniprot.org/uniprot/P9WFG5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||UPF0719 transmembrane protein Rv2600 ^@ http://purl.uniprot.org/annotation/PRO_0000104070 http://togogenome.org/gene/83332:Rv3449 ^@ http://purl.uniprot.org/uniprot/I6YC58 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Charge relay system|||Helical|||Mycosin-4|||Peptidase S8 ^@ http://purl.uniprot.org/annotation/PRO_5007674266 http://togogenome.org/gene/83332:Rv1245c ^@ http://purl.uniprot.org/uniprot/O50460 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2780 ^@ http://purl.uniprot.org/uniprot/P9WQB1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Sequence Conflict|||Strand|||Turn ^@ Alanine dehydrogenase|||Completely inactive mutant.|||Completely inactive mutant. The bifurcated hydrogen bond between D-270 and the ribose of NAD is replaced by a single hydrogen bond.|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000198994 http://togogenome.org/gene/83332:Rv3135 ^@ http://purl.uniprot.org/uniprot/Q6MX07 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE50 ^@ http://purl.uniprot.org/annotation/PRO_0000378484 http://togogenome.org/gene/83332:Rv0137c ^@ http://purl.uniprot.org/uniprot/P9WJM5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Peptide methionine sulfoxide reductase MsrA ^@ http://purl.uniprot.org/annotation/PRO_0000138560 http://togogenome.org/gene/83332:Rv1900c ^@ http://purl.uniprot.org/uniprot/O07732 ^@ Region ^@ Domain Extent ^@ Guanylate cyclase ^@ http://togogenome.org/gene/83332:Rv3063 ^@ http://purl.uniprot.org/uniprot/P9WP47 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Peptide transporter CstA ^@ http://purl.uniprot.org/annotation/PRO_0000190049 http://togogenome.org/gene/83332:Rv3578 ^@ http://purl.uniprot.org/uniprot/I6YCG9 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical ^@ http://purl.uniprot.org/annotation/PRO_5010223155 http://togogenome.org/gene/83332:Rv0282 ^@ http://purl.uniprot.org/uniprot/P9WPI3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ ESX-3 secretion system protein EccA3 ^@ http://purl.uniprot.org/annotation/PRO_0000063045 http://togogenome.org/gene/83332:Rv0808 ^@ http://purl.uniprot.org/uniprot/P9WHQ7 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Propeptide ^@ Amidophosphoribosyltransferase|||Glutamine amidotransferase type-2|||Nucleophile|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000029257|||http://purl.uniprot.org/annotation/PRO_0000029258 http://togogenome.org/gene/83332:Rv2899c ^@ http://purl.uniprot.org/uniprot/P9WNF1 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Cysteine persulfide intermediate|||Sulfur carrier protein FdhD ^@ http://purl.uniprot.org/annotation/PRO_0000152912 http://togogenome.org/gene/83332:Rv3396c ^@ http://purl.uniprot.org/uniprot/P9WMS7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Mass|||Modified Residue ^@ GMP synthase [glutamine-hydrolyzing]|||GMPS ATP-PPase|||Glutamine amidotransferase type-1|||N-acetylvaline|||Nucleophile|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000140149 http://togogenome.org/gene/83332:Rv0635 ^@ http://purl.uniprot.org/uniprot/P9WFK1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ UPF0336 protein Rv0635 ^@ http://purl.uniprot.org/annotation/PRO_0000216143 http://togogenome.org/gene/83332:Rv0106 ^@ http://purl.uniprot.org/uniprot/P9WPI5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ CXCC motif|||CobW C-terminal|||Zinc chaperone Rv0106 ^@ http://purl.uniprot.org/annotation/PRO_0000103676 http://togogenome.org/gene/83332:Rv1826 ^@ http://purl.uniprot.org/uniprot/P9WN55 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Glycine cleavage system H protein|||Lipoyl-binding|||N-acetylserine|||N6-lipoyllysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000166228 http://togogenome.org/gene/83332:Rv2293c ^@ http://purl.uniprot.org/uniprot/P9WLE1 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2293c ^@ http://purl.uniprot.org/annotation/PRO_0000014130 http://togogenome.org/gene/83332:Rv0930 ^@ http://purl.uniprot.org/uniprot/P9WG11 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Sequence Conflict|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Phosphate transport system permease protein PstA 1 ^@ http://purl.uniprot.org/annotation/PRO_0000060201 http://togogenome.org/gene/83332:Rv2124c ^@ http://purl.uniprot.org/uniprot/O33259 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ AdoMet activation|||B12-binding|||B12-binding N-terminal|||Basic and acidic residues|||Hcy-binding|||Methionine synthase|||Pterin-binding|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000204534 http://togogenome.org/gene/83332:Rv2443 ^@ http://purl.uniprot.org/uniprot/P71906 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv0752c ^@ http://purl.uniprot.org/uniprot/I6Y4R2 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv2958c ^@ http://purl.uniprot.org/uniprot/P9WFR1 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c ^@ http://purl.uniprot.org/annotation/PRO_0000314436 http://togogenome.org/gene/83332:Rv0225 ^@ http://purl.uniprot.org/uniprot/P96407 ^@ Region ^@ Domain Extent ^@ Glyco_trans_4-like_N|||Glycos_transf_1 ^@ http://togogenome.org/gene/83332:Rv1941 ^@ http://purl.uniprot.org/uniprot/I6XZC4 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv0500A ^@ http://purl.uniprot.org/uniprot/P9WKT7 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding ^@ H-T-H motif|||Putative DNA-binding protein Rv0500A ^@ http://purl.uniprot.org/annotation/PRO_0000399397 http://togogenome.org/gene/83332:Rv2790c ^@ http://purl.uniprot.org/uniprot/O33332 ^@ Region ^@ Domain Extent ^@ Thiolase_C|||Thiolase_N ^@ http://togogenome.org/gene/83332:Rv0257 ^@ http://purl.uniprot.org/uniprot/L7N694 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv2260 ^@ http://purl.uniprot.org/uniprot/O53534 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv1752 ^@ http://purl.uniprot.org/uniprot/O06789 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0898c ^@ http://purl.uniprot.org/uniprot/P9WKP5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0898c ^@ http://purl.uniprot.org/annotation/PRO_0000103739 http://togogenome.org/gene/83332:Rv1720c ^@ http://purl.uniprot.org/uniprot/P9WFA3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribonuclease VapC12 ^@ http://purl.uniprot.org/annotation/PRO_0000407873 http://togogenome.org/gene/83332:Rv1783 ^@ http://purl.uniprot.org/uniprot/P9WNA5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Transmembrane|||Turn ^@ ESX-5 secretion system protein EccC5|||FtsK 1|||FtsK 2|||FtsK 3|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393433 http://togogenome.org/gene/83332:Rv0279c ^@ http://purl.uniprot.org/uniprot/L0T4W6 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv1170 ^@ http://purl.uniprot.org/uniprot/P9WJN3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase ^@ http://purl.uniprot.org/annotation/PRO_0000399826 http://togogenome.org/gene/83332:Rv2909c ^@ http://purl.uniprot.org/uniprot/P9WH53 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S16 ^@ http://purl.uniprot.org/annotation/PRO_0000167213 http://togogenome.org/gene/83332:Rv2390c ^@ http://purl.uniprot.org/uniprot/P71754 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0117 ^@ http://purl.uniprot.org/uniprot/L7N677 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH lysR-type ^@ http://togogenome.org/gene/83332:Rv1303 ^@ http://purl.uniprot.org/uniprot/P9WM31 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1303 ^@ http://purl.uniprot.org/annotation/PRO_0000103793 http://togogenome.org/gene/83332:Rv3044 ^@ http://purl.uniprot.org/uniprot/O53291 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Fe/B12 periplasmic-binding ^@ http://purl.uniprot.org/annotation/PRO_5010306775 http://togogenome.org/gene/83332:Rv1139c ^@ http://purl.uniprot.org/uniprot/O06539 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1962c ^@ http://purl.uniprot.org/uniprot/P9WF67 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC35 ^@ http://purl.uniprot.org/annotation/PRO_0000407891 http://togogenome.org/gene/83332:Rv0594 ^@ http://purl.uniprot.org/uniprot/O07784 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv3727 ^@ http://purl.uniprot.org/uniprot/O69694 ^@ Region ^@ Domain Extent ^@ Amino_oxidase ^@ http://togogenome.org/gene/83332:Rv3310 ^@ http://purl.uniprot.org/uniprot/O53361 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Phosphatidylinositol-3-phosphatase ^@ http://purl.uniprot.org/annotation/PRO_5008778597 http://togogenome.org/gene/83332:Rv1423 ^@ http://purl.uniprot.org/uniprot/P9WF45 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Initiator Methionine ^@ H-T-H motif|||Probable cell division protein WhiA|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000376534 http://togogenome.org/gene/83332:Rv1599 ^@ http://purl.uniprot.org/uniprot/P9WNW9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Initiator Methionine ^@ Histidinol dehydrogenase|||Proton acceptor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000135799 http://togogenome.org/gene/83332:Rv1255c ^@ http://purl.uniprot.org/uniprot/P9WMD5 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv1255c ^@ http://purl.uniprot.org/annotation/PRO_0000070660 http://togogenome.org/gene/83332:Rv2078 ^@ http://purl.uniprot.org/uniprot/P9WLK9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2078 ^@ http://purl.uniprot.org/annotation/PRO_0000103950 http://togogenome.org/gene/83332:Rv3198A ^@ http://purl.uniprot.org/uniprot/P9WN17 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Glutaredoxin|||Putative glutaredoxin Rv3198.1 ^@ http://purl.uniprot.org/annotation/PRO_0000363861 http://togogenome.org/gene/83332:Rv0346c ^@ http://purl.uniprot.org/uniprot/P9WQM7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||L-asparagine permease 2 ^@ http://purl.uniprot.org/annotation/PRO_0000054190 http://togogenome.org/gene/83332:Rv0147 ^@ http://purl.uniprot.org/uniprot/P96824 ^@ Region|||Site ^@ Active Site|||Compositionally Biased Region|||Domain Extent ^@ Aldedh|||Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv1910c ^@ http://purl.uniprot.org/uniprot/P9WFN5 ^@ Molecule Processing ^@ Chain ^@ UPF0098 protein Rv1910c ^@ http://purl.uniprot.org/annotation/PRO_0000137905 http://togogenome.org/gene/83332:Rv3074 ^@ http://purl.uniprot.org/uniprot/I6XG38 ^@ Region ^@ Domain Extent ^@ HNHc ^@ http://togogenome.org/gene/83332:Rv3630 ^@ http://purl.uniprot.org/uniprot/P9WKX9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv3630 ^@ http://purl.uniprot.org/annotation/PRO_0000104142 http://togogenome.org/gene/83332:Rv2748c ^@ http://purl.uniprot.org/uniprot/P9WNA3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Topological Domain|||Transmembrane ^@ Basic residues|||Cytoplasmic|||DNA translocase FtsK|||FtsK|||Helical|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000098271 http://togogenome.org/gene/83332:Rv0331 ^@ http://purl.uniprot.org/uniprot/O07255 ^@ Region ^@ Domain Extent ^@ Pyr_redox_2 ^@ http://togogenome.org/gene/83332:Rv3589 ^@ http://purl.uniprot.org/uniprot/P9WQ09 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ Adenine DNA glycosylase|||HhH|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000421385 http://togogenome.org/gene/83332:Rv0819 ^@ http://purl.uniprot.org/uniprot/P9WJM7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Mycothiol acetyltransferase|||N-acetyltransferase 1|||N-acetyltransferase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000399828 http://togogenome.org/gene/83332:Rv0294 ^@ http://purl.uniprot.org/uniprot/P9WGA3 ^@ Molecule Processing ^@ Chain ^@ Probable trans-aconitate 2-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000218082 http://togogenome.org/gene/83332:Rv2575 ^@ http://purl.uniprot.org/uniprot/P9WL85 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Uncharacterized protein Rv2575 ^@ http://purl.uniprot.org/annotation/PRO_0000104056 http://togogenome.org/gene/83332:Rv3407 ^@ http://purl.uniprot.org/uniprot/P9WF23 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB47 ^@ http://purl.uniprot.org/annotation/PRO_0000104127 http://togogenome.org/gene/83332:Rv0646c ^@ http://purl.uniprot.org/uniprot/P96935 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv3594 ^@ http://purl.uniprot.org/uniprot/I6Y3Z2 ^@ Region ^@ Domain Extent ^@ N-acetylmuramoyl-L-alanine amidase ^@ http://togogenome.org/gene/83332:Rv2303c ^@ http://purl.uniprot.org/uniprot/Q50662 ^@ Region ^@ Domain Extent ^@ Amidohydro-rel ^@ http://togogenome.org/gene/83332:Rv0943c ^@ http://purl.uniprot.org/uniprot/P9WKN7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0943c ^@ http://purl.uniprot.org/annotation/PRO_0000103747 http://togogenome.org/gene/83332:Rv1307 ^@ http://purl.uniprot.org/uniprot/P9WPV3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ATP synthase subunit b-delta|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000193473 http://togogenome.org/gene/83332:Rv1275 ^@ http://purl.uniprot.org/uniprot/O86337 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010284891 http://togogenome.org/gene/83332:Rv2136c ^@ http://purl.uniprot.org/uniprot/P9WFF9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Undecaprenyl-diphosphatase ^@ http://purl.uniprot.org/annotation/PRO_0000151166 http://togogenome.org/gene/83332:Rv2968c ^@ http://purl.uniprot.org/uniprot/I6X5W1 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||VKc ^@ http://togogenome.org/gene/83332:Rv0235c ^@ http://purl.uniprot.org/uniprot/P96418 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0765c ^@ http://purl.uniprot.org/uniprot/I6WZD9 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv0589 ^@ http://purl.uniprot.org/uniprot/Q79FY7 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv2800 ^@ http://purl.uniprot.org/uniprot/I6YEE6 ^@ Region ^@ Domain Extent ^@ PepX_C ^@ http://togogenome.org/gene/83332:Rv0908 ^@ http://purl.uniprot.org/uniprot/P9WPT1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Calcium-transporting ATPase CtpE|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000046341 http://togogenome.org/gene/83332:Rv1803c ^@ http://purl.uniprot.org/uniprot/Q79FJ9 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3265c ^@ http://purl.uniprot.org/uniprot/P9WMY3 ^@ Molecule Processing ^@ Chain|||Initiator Methionine ^@ N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000395354 http://togogenome.org/gene/83332:Rv2606c ^@ http://purl.uniprot.org/uniprot/P9WII9 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink|||Helix|||Strand|||Turn ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Pyridoxal 5'-phosphate synthase subunit PdxS|||Schiff-base intermediate with D-ribose 5-phosphate ^@ http://purl.uniprot.org/annotation/PRO_0000109405 http://togogenome.org/gene/83332:Rv3085 ^@ http://purl.uniprot.org/uniprot/P9WGP9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Putative oxidoreductase SadH ^@ http://purl.uniprot.org/annotation/PRO_0000420878 http://togogenome.org/gene/83332:Rv0342 ^@ http://purl.uniprot.org/uniprot/P9WJ99 ^@ Molecule Processing|||Region ^@ Chain|||Coiled-Coil|||Transmembrane ^@ Helical|||Isoniazid-induced protein IniA ^@ http://purl.uniprot.org/annotation/PRO_0000390791 http://togogenome.org/gene/83332:Rv3465 ^@ http://purl.uniprot.org/uniprot/P9WH11 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||Proton donor|||dTDP-4-dehydrorhamnose 3,5-epimerase ^@ http://purl.uniprot.org/annotation/PRO_0000395349 http://togogenome.org/gene/83332:Rv1570 ^@ http://purl.uniprot.org/uniprot/P9WPQ5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Decreases affinity for NaHCO(3) 3-fold, for CTP 1.8-fold and for GTP 3.8-fold.|||Dethiobiotin synthetase BioD ^@ http://purl.uniprot.org/annotation/PRO_0000187977 http://togogenome.org/gene/83332:Rv2402 ^@ http://purl.uniprot.org/uniprot/P71741 ^@ Molecule Processing ^@ Chain ^@ Trehalase ^@ http://purl.uniprot.org/annotation/PRO_0000413980 http://togogenome.org/gene/83332:Rv2920c ^@ http://purl.uniprot.org/uniprot/P9WQ65 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Ammonium transporter|||Basic and acidic residues|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000139758 http://togogenome.org/gene/83332:Rv2877c ^@ http://purl.uniprot.org/uniprot/I6YEL8 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DsbD|||Helical ^@ http://togogenome.org/gene/83332:Rv3055 ^@ http://purl.uniprot.org/uniprot/P95103 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1836c ^@ http://purl.uniprot.org/uniprot/P9WLQ9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Uncharacterized protein Rv1836c ^@ http://purl.uniprot.org/annotation/PRO_0000103910 http://togogenome.org/gene/83332:Rv1372 ^@ http://purl.uniprot.org/uniprot/P9WPF1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Alpha-pyrone synthesis polyketide synthase-like Pks18|||Cannot be recovered in the soluble form.|||Completely abolishes the polyketide synthase activity with lauroyl-CoA and palmitoyl-CoA.|||Efficiently catalyzed the synthesis of the triketide pyrone of the C6 starter unit and shows weak polyketide synthase activity with the C12 starter molecule.|||Increase in the synthesis of the tetraketide products.|||Loss of polyketide synthase activity.|||No significant change in polyketide synthase activity.|||Nucleophile|||Retained reasonable polyketide synthase activity with lauroyl-CoA but cannot use palmitoyl-CoA.|||Unable to synthesize any polyketide products. ^@ http://purl.uniprot.org/annotation/PRO_0000407320 http://togogenome.org/gene/83332:Rv0461 ^@ http://purl.uniprot.org/uniprot/I6X961 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Protein Rv0461 ^@ http://purl.uniprot.org/annotation/PRO_0000456389 http://togogenome.org/gene/83332:Rv2502c ^@ http://purl.uniprot.org/uniprot/I6YDK7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase beta1 subunit|||CoA carboxyltransferase C-terminal|||CoA carboxyltransferase N-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000452368 http://togogenome.org/gene/83332:Rv0288 ^@ http://purl.uniprot.org/uniprot/P9WNK3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ ESAT-6-like protein EsxH|||No change in activity.|||Still interacts with EsxG, but impairs interaction with host HGS/HRS; when associated with A-76.|||Still interacts with EsxG, but impairs interaction with host HGS/HRS; when associated with A-77. ^@ http://purl.uniprot.org/annotation/PRO_0000167798 http://togogenome.org/gene/83332:Rv1973 ^@ http://purl.uniprot.org/uniprot/P9WJ77 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Outer membrane protein Rv1973 ^@ http://purl.uniprot.org/annotation/PRO_0000415941 http://togogenome.org/gene/83332:Rv0604 ^@ http://purl.uniprot.org/uniprot/I6X9E2 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010314124 http://togogenome.org/gene/83332:Rv1470 ^@ http://purl.uniprot.org/uniprot/O53161 ^@ Region ^@ Domain Extent ^@ Thioredoxin ^@ http://togogenome.org/gene/83332:Rv3737 ^@ http://purl.uniprot.org/uniprot/O69704 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable threonine/serine exporter ^@ http://purl.uniprot.org/annotation/PRO_0000456292 http://togogenome.org/gene/83332:Rv0246 ^@ http://purl.uniprot.org/uniprot/O53668 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1799 ^@ http://purl.uniprot.org/uniprot/O53948 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010168523 http://togogenome.org/gene/83332:Rv0429c ^@ http://purl.uniprot.org/uniprot/P9WIJ3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Peptide deformylase ^@ http://purl.uniprot.org/annotation/PRO_0000082806 http://togogenome.org/gene/83332:Rv1265 ^@ http://purl.uniprot.org/uniprot/P9WM49 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1265 ^@ http://purl.uniprot.org/annotation/PRO_0000103780 http://togogenome.org/gene/83332:Rv1940 ^@ http://purl.uniprot.org/uniprot/L7N669 ^@ Region ^@ Domain Extent ^@ GTP_cyclohydro2 ^@ http://togogenome.org/gene/83332:Rv2089c ^@ http://purl.uniprot.org/uniprot/P9WHS7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Transmembrane ^@ Helical|||Probable dipeptidase PepE ^@ http://purl.uniprot.org/annotation/PRO_0000185102 http://togogenome.org/gene/83332:Rv0456A ^@ http://purl.uniprot.org/uniprot/Q6MX40 ^@ Molecule Processing ^@ Chain ^@ Probable endoribonuclease MazF1 ^@ http://purl.uniprot.org/annotation/PRO_0000406304 http://togogenome.org/gene/83332:Rv1922 ^@ http://purl.uniprot.org/uniprot/P95291 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Beta-lactamase ^@ http://purl.uniprot.org/annotation/PRO_5010317647 http://togogenome.org/gene/83332:Rv2447c ^@ http://purl.uniprot.org/uniprot/I6Y0R5 ^@ Molecule Processing|||Natural Variation|||Site ^@ Binding Site|||Chain|||Sequence Variant ^@ Dihydrofolate synthase/folylpolyglutamate synthase|||In a spontaneous PAS-resistant mutant strain.|||In a spontaneous PAS-resistant mutant strain; complementation with wild-type folC restores PAS susceptibility, confirmimg that this mutation confers high level resistance to PAS.|||In a spontaneous PAS-resistant mutant strain; complementation with wild-type folC restores PAS susceptibility.|||In a spontaneous PAS-resistant mutant strain; complementation with wild-type folC restores PAS susceptibility; 5-fold reduction in DHFS activity relative to wild-type; loss of the ability to glutaminate H2PtePAS.|||In clinical isolate: Q36; PAS-resistant; complementation with wild-type folC restores PAS susceptibility.|||In clinical isolates: Q274 and 501063; PAS-resistant; complementation with wild-type folC restores PAS susceptibility.|||In clinical isolates: Q449 and 1314; PAS-resistant; complementation with wild-type folC restores PAS susceptibility; 7-fold reduction in DHFS activity relative to wild-type; loss of the ability to glutaminate H2PtePAS. ^@ http://purl.uniprot.org/annotation/PRO_0000439040 http://togogenome.org/gene/83332:Rv3642c ^@ http://purl.uniprot.org/uniprot/I6Y464 ^@ Region ^@ Domain Extent ^@ VbhA ^@ http://togogenome.org/gene/83332:Rv2759c ^@ http://purl.uniprot.org/uniprot/P9WF57 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC42 ^@ http://purl.uniprot.org/annotation/PRO_0000221203 http://togogenome.org/gene/83332:Rv2413c ^@ http://purl.uniprot.org/uniprot/P71730 ^@ Region ^@ Domain Extent ^@ DNA_pol3_delta ^@ http://togogenome.org/gene/83332:Rv2586c ^@ http://purl.uniprot.org/uniprot/P9WGN9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Polar residues|||Protein translocase subunit SecF ^@ http://purl.uniprot.org/annotation/PRO_0000095983 http://togogenome.org/gene/83332:Rv3018c ^@ http://purl.uniprot.org/uniprot/P9WHY9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE46 ^@ http://purl.uniprot.org/annotation/PRO_0000217851 http://togogenome.org/gene/83332:Rv3417c ^@ http://purl.uniprot.org/uniprot/P9WPE9 ^@ Experimental Information|||Modification|||Molecule Processing|||Natural Variation|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Sequence Variant|||Strand|||Turn ^@ Cannot bind nickel, cobalt or copper.|||Chaperonin GroEL 1|||In strain: Erdman.|||Lack of phosphorylation by PknF; when associated with A-25.|||Lack of phosphorylation by PknF; when associated with A-54.|||N-acetylserine|||Phosphoserine; in tetradecamer|||Phosphothreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000063451 http://togogenome.org/gene/83332:Rv0657c ^@ http://purl.uniprot.org/uniprot/P9WJ57 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB6 ^@ http://purl.uniprot.org/annotation/PRO_0000408054 http://togogenome.org/gene/83332:Rv1452c ^@ http://purl.uniprot.org/uniprot/Q79FP1 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1493 ^@ http://purl.uniprot.org/uniprot/P9WJK5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ B12-binding|||Probable methylmalonyl-CoA mutase large subunit|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000194270 http://togogenome.org/gene/83332:Rv0955 ^@ http://purl.uniprot.org/uniprot/P9WKN3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0955 ^@ http://purl.uniprot.org/annotation/PRO_0000103751 http://togogenome.org/gene/83332:Rv1317c ^@ http://purl.uniprot.org/uniprot/P9WJW3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH araC/xylS-type|||Nucleophile; methyl group acceptor from methylphosphotriester|||Probable bifunctional transcriptional activator/DNA repair enzyme AlkA|||Proton acceptor; for DNA glycosylase activity ^@ http://purl.uniprot.org/annotation/PRO_0000139389 http://togogenome.org/gene/83332:Rv2708c ^@ http://purl.uniprot.org/uniprot/I6X562 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0775 ^@ http://purl.uniprot.org/uniprot/P71830 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0717 ^@ http://purl.uniprot.org/uniprot/P9WH57 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 30S ribosomal protein S14 type Z ^@ http://purl.uniprot.org/annotation/PRO_0000130910 http://togogenome.org/gene/83332:Rv1610 ^@ http://purl.uniprot.org/uniprot/O06128 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv2812 ^@ http://purl.uniprot.org/uniprot/P71639 ^@ Region ^@ Domain Extent ^@ Integrase catalytic ^@ http://togogenome.org/gene/83332:Rv3666c ^@ http://purl.uniprot.org/uniprot/I6X811 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ SBP_bac_5 ^@ http://purl.uniprot.org/annotation/PRO_5010288528 http://togogenome.org/gene/83332:Rv1438 ^@ http://purl.uniprot.org/uniprot/P9WG43 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mass|||Strand|||Turn ^@ Electrophile|||Proton acceptor|||Triosephosphate isomerase ^@ http://purl.uniprot.org/annotation/PRO_0000090256 http://togogenome.org/gene/83332:Rv2277c ^@ http://purl.uniprot.org/uniprot/P9WLF1 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Signal Peptide|||Strand|||Turn ^@ GP-PDE|||Uncharacterized protein Rv2277c ^@ http://purl.uniprot.org/annotation/PRO_0000014127 http://togogenome.org/gene/83332:Rv3095 ^@ http://purl.uniprot.org/uniprot/P9WMG3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ HTH hxlR-type|||Uncharacterized HTH-type transcriptional regulator Rv3095 ^@ http://purl.uniprot.org/annotation/PRO_0000148890 http://togogenome.org/gene/83332:Rv0356c ^@ http://purl.uniprot.org/uniprot/O06307 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ 4HBT|||Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv3481c ^@ http://purl.uniprot.org/uniprot/I6XHC3 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2109c ^@ http://purl.uniprot.org/uniprot/P9WHU1 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand ^@ Markedly increases peptidolytic activity. Disappearance of the apparent obstruction in alpha rings. Designated open-gate mutant.|||N-acetylserine; partial|||Phosphothreonine|||Proteasome subunit alpha|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000383482 http://togogenome.org/gene/83332:Rv3283 ^@ http://purl.uniprot.org/uniprot/P9WHF7 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Cysteine persulfide intermediate|||N-acetylproline|||Putative thiosulfate sulfurtransferase SseA|||Removed|||Rhodanese 1|||Rhodanese 2 ^@ http://purl.uniprot.org/annotation/PRO_0000139418 http://togogenome.org/gene/83332:Rv2930 ^@ http://purl.uniprot.org/uniprot/P9WQ43 ^@ Molecule Processing ^@ Chain ^@ Long-chain-fatty-acid--AMP ligase FadD26 ^@ http://purl.uniprot.org/annotation/PRO_0000193138 http://togogenome.org/gene/83332:Rv3100c ^@ http://purl.uniprot.org/uniprot/P9WGD3 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ SsrA-binding protein ^@ http://purl.uniprot.org/annotation/PRO_0000102991 http://togogenome.org/gene/83332:Rv3779 ^@ http://purl.uniprot.org/uniprot/P72045 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3066 ^@ http://purl.uniprot.org/uniprot/I6X658 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1012 ^@ http://purl.uniprot.org/uniprot/O05597 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv1848 ^@ http://purl.uniprot.org/uniprot/P9WFE7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Sequence Conflict|||Strand ^@ Urease subunit gamma ^@ http://purl.uniprot.org/annotation/PRO_0000098019 http://togogenome.org/gene/83332:Rv0975c ^@ http://purl.uniprot.org/uniprot/O86319 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv0474 ^@ http://purl.uniprot.org/uniprot/P9WMH9 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH cro/C1-type|||Uncharacterized HTH-type transcriptional regulator Rv0474 ^@ http://purl.uniprot.org/annotation/PRO_0000382635 http://togogenome.org/gene/83332:Rv3609c ^@ http://purl.uniprot.org/uniprot/P9WN57 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ GTP cyclohydrolase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000119423 http://togogenome.org/gene/83332:Rv0800 ^@ http://purl.uniprot.org/uniprot/P9WHT1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable M18 family aminopeptidase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000173464 http://togogenome.org/gene/83332:Rv2512c ^@ http://purl.uniprot.org/uniprot/P60230 ^@ Molecule Processing ^@ Chain ^@ Transposase for insertion sequence element IS1081 ^@ http://purl.uniprot.org/annotation/PRO_0000211350 http://togogenome.org/gene/83332:Rv0300 ^@ http://purl.uniprot.org/uniprot/O07227 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ Antitoxin VapB2 ^@ http://purl.uniprot.org/annotation/PRO_0000408052 http://togogenome.org/gene/83332:Rv0615 ^@ http://purl.uniprot.org/uniprot/O07762 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3750c ^@ http://purl.uniprot.org/uniprot/O69717 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB50 ^@ http://purl.uniprot.org/annotation/PRO_0000433059 http://togogenome.org/gene/83332:Rv0794c ^@ http://purl.uniprot.org/uniprot/I6Y4U4 ^@ Modification|||Region|||Site ^@ Binding Site|||Disulfide Bond|||Domain Extent ^@ Pyr_redox_2|||Pyr_redox_dim|||Redox-active ^@ http://togogenome.org/gene/83332:Rv1817 ^@ http://purl.uniprot.org/uniprot/Q50616 ^@ Region ^@ Domain Extent ^@ FAD_binding_2 ^@ http://togogenome.org/gene/83332:Rv0440 ^@ http://purl.uniprot.org/uniprot/P9WPE7 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes cleavage by Hip1.|||Chaperonin GroEL 2|||Cleaved form|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000063452|||http://purl.uniprot.org/annotation/PRO_0000453198 http://togogenome.org/gene/83332:Rv2063A ^@ http://purl.uniprot.org/uniprot/P0CL62 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Probable endoribonuclease MazF7 ^@ http://purl.uniprot.org/annotation/PRO_0000406308 http://togogenome.org/gene/83332:Rv1280c ^@ http://purl.uniprot.org/uniprot/P9WGU5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1280c ^@ http://purl.uniprot.org/annotation/PRO_0000062776 http://togogenome.org/gene/83332:Rv2101 ^@ http://purl.uniprot.org/uniprot/I6YCF3 ^@ Region ^@ Domain Extent ^@ Helicase ATP-binding|||Helicase C-terminal ^@ http://togogenome.org/gene/83332:Rv2629 ^@ http://purl.uniprot.org/uniprot/P9WL63 ^@ Molecule Processing|||Natural Variation|||Region ^@ Chain|||Coiled-Coil|||Sequence Variant ^@ Common variant in the Beijing-W clade/SCG-2 phylogenetic group.|||Uncharacterized protein Rv2629 ^@ http://purl.uniprot.org/annotation/PRO_0000392936 http://togogenome.org/gene/83332:Rv1112 ^@ http://purl.uniprot.org/uniprot/O53459 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ OBG-type G|||TGS ^@ http://togogenome.org/gene/83332:Rv0511 ^@ http://purl.uniprot.org/uniprot/Q6MX34 ^@ Region ^@ Domain Extent ^@ HEM4|||TP_methylase ^@ http://togogenome.org/gene/83332:Rv2457c ^@ http://purl.uniprot.org/uniprot/P9WPB9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ATP-dependent Clp protease ATP-binding subunit ClpX|||ClpX-type ZB ^@ http://purl.uniprot.org/annotation/PRO_0000160388 http://togogenome.org/gene/83332:Rv1932 ^@ http://purl.uniprot.org/uniprot/P9WG35 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes catalytic activity.|||Cysteine sulfenic acid (-SOH) intermediate|||Increases catalytic activity.|||Redox-active|||Thiol peroxidase|||Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000187888 http://togogenome.org/gene/83332:Rv2773c ^@ http://purl.uniprot.org/uniprot/P9WP23 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Sequence Conflict|||Strand|||Turn ^@ 2.8-fold increase in catalytic activity with NADH as substrate, while the affinity for NADH is essentially unaffected. 70-fold decrease in affinity for NADPH, causing the nucleotide specificity to increase from 6:1 for the wild-type enzyme to 187:1.|||4-hydroxy-tetrahydrodipicolinate reductase|||Increases the nucleotide specificity from 6:1 for the wild-type enzyme to 34:1, due to a 4-fold decrease in NADPH affinity while the affinity for NADH remains nearly unchanged.|||Proton donor|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000141458 http://togogenome.org/gene/83332:Rv3655c ^@ http://purl.uniprot.org/uniprot/O69623 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Apoptosis inhibitor Rv3655c ^@ http://purl.uniprot.org/annotation/PRO_0000438184 http://togogenome.org/gene/83332:Rv0563 ^@ http://purl.uniprot.org/uniprot/P9WHS5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ Helical|||Protease HtpX homolog ^@ http://purl.uniprot.org/annotation/PRO_0000138875 http://togogenome.org/gene/83332:Rv2597 ^@ http://purl.uniprot.org/uniprot/P9WL73 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2597 ^@ http://purl.uniprot.org/annotation/PRO_0000104065 http://togogenome.org/gene/83332:Rv3436c ^@ http://purl.uniprot.org/uniprot/P9WN49 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Initiator Methionine ^@ For Fru-6P isomerization activity|||Glutamine amidotransferase type-2|||Glutamine--fructose-6-phosphate aminotransferase [isomerizing]|||Nucleophile; for GATase activity|||Removed|||SIS 1|||SIS 2 ^@ http://purl.uniprot.org/annotation/PRO_0000135357 http://togogenome.org/gene/83332:Rv1548c ^@ http://purl.uniprot.org/uniprot/P9WI21 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized PPE family protein PPE21 ^@ http://purl.uniprot.org/annotation/PRO_0000217846 http://togogenome.org/gene/83332:Rv0134 ^@ http://purl.uniprot.org/uniprot/P96811 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv3253c ^@ http://purl.uniprot.org/uniprot/O05896 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0965c ^@ http://purl.uniprot.org/uniprot/P9WKM3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0965c ^@ http://purl.uniprot.org/annotation/PRO_0000103763 http://togogenome.org/gene/83332:Rv2718c ^@ http://purl.uniprot.org/uniprot/P9WIZ1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Zinc Finger ^@ ATP-cone|||Transcriptional repressor NrdR ^@ http://purl.uniprot.org/annotation/PRO_0000182321 http://togogenome.org/gene/83332:Rv1328 ^@ http://purl.uniprot.org/uniprot/P9WMW1 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ Glycogen phosphorylase|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000188556 http://togogenome.org/gene/83332:Rv1620c ^@ http://purl.uniprot.org/uniprot/O06137 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||ABC transporter|||Helical ^@ http://togogenome.org/gene/83332:Rv1449c ^@ http://purl.uniprot.org/uniprot/P9WG25 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylthreonine|||Proton donor|||Removed|||Transketolase ^@ http://purl.uniprot.org/annotation/PRO_0000191863 http://togogenome.org/gene/83332:Rv3676 ^@ http://purl.uniprot.org/uniprot/P9WMH3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||DNA Binding|||Domain Extent|||Helix|||Strand ^@ CRP-like cAMP-activated global transcriptional regulator|||H-T-H motif|||HTH crp-type ^@ http://purl.uniprot.org/annotation/PRO_0000420402 http://togogenome.org/gene/83332:Rv2290 ^@ http://purl.uniprot.org/uniprot/P9WK71 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppO|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018114 http://togogenome.org/gene/83332:Rv1943c ^@ http://purl.uniprot.org/uniprot/P9WJ89 ^@ Molecule Processing ^@ Chain ^@ Antitoxin MazE5 ^@ http://purl.uniprot.org/annotation/PRO_0000406299 http://togogenome.org/gene/83332:Rv3106 ^@ http://purl.uniprot.org/uniprot/P9WIQ3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ NADPH-ferredoxin reductase FprA|||No effect on activity. Decreases Km for NADP 2-fold.|||Reduces activity 4-fold. ^@ http://purl.uniprot.org/annotation/PRO_0000087329 http://togogenome.org/gene/83332:Rv0366c ^@ http://purl.uniprot.org/uniprot/O53701 ^@ Region ^@ Domain Extent ^@ Zeta_toxin ^@ http://togogenome.org/gene/83332:Rv3491 ^@ http://purl.uniprot.org/uniprot/I6XHD1 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Secreted protein ^@ http://purl.uniprot.org/annotation/PRO_5030172888 http://togogenome.org/gene/83332:Rv2119 ^@ http://purl.uniprot.org/uniprot/O33254 ^@ Region ^@ Domain Extent ^@ PDDEXK_1 ^@ http://togogenome.org/gene/83332:Rv1591 ^@ http://purl.uniprot.org/uniprot/P9WLT5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1591 ^@ http://purl.uniprot.org/annotation/PRO_0000103891 http://togogenome.org/gene/83332:Rv2940c ^@ http://purl.uniprot.org/uniprot/I6Y231 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv3791 ^@ http://purl.uniprot.org/uniprot/P9WGS9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000054860 http://togogenome.org/gene/83332:Rv2418c ^@ http://purl.uniprot.org/uniprot/P71725 ^@ Molecule Processing ^@ Chain ^@ Diglucosylglycerate octanoyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000436913 http://togogenome.org/gene/83332:Rv0667 ^@ http://purl.uniprot.org/uniprot/P9WGY9 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Mutagenesis Site|||Sequence Conflict|||Sequence Variant|||Strand|||Turn ^@ DNA-directed RNA polymerase subunit beta|||Does not affect association with TRCF, but weakens interaction with CarD.|||In strain: RJ37; rifampicin-resistant.|||In strain: RJ48; rifampicin-resistant.|||In strain: RJ49; rifampicin-resistant.|||In strain: RJ55; rifampicin-resistant.|||In strain: SP28; rifampicin-resistant.|||In strain: vr10; rifampicin-resistant.|||In strain: vr11 and RJ37; rifampicin-resistant.|||In strain: vr12 and SP22; rifampicin-resistant.|||In strain: vr1; rifampicin-resistant.|||In strain: vr2; rifampicin-resistant.|||In strain: vr3; rifampicin-resistant.|||In strain: vr4; rifampicin-resistant.|||In strain: vr5; rifampicin-resistant.|||In strain: vr6; rifampicin-resistant.|||In strain: vr7; rifampicin-resistant.|||In strain: vr8; rifampicin-resistant.|||In strain: vr9; rifampicin-resistant.|||Polar residues|||Weakens interaction with TRCF and CarD. ^@ http://purl.uniprot.org/annotation/PRO_0000047927 http://togogenome.org/gene/83332:Rv0484c ^@ http://purl.uniprot.org/uniprot/P9WGR5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv0484c ^@ http://purl.uniprot.org/annotation/PRO_0000054863 http://togogenome.org/gene/83332:Rv3620c ^@ http://purl.uniprot.org/uniprot/P9WNI3 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxW ^@ http://purl.uniprot.org/annotation/PRO_0000167816 http://togogenome.org/gene/83332:Rv3422c ^@ http://purl.uniprot.org/uniprot/P9WFS7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ tRNA threonylcarbamoyladenosine biosynthesis protein TsaE ^@ http://purl.uniprot.org/annotation/PRO_0000096214 http://togogenome.org/gene/83332:Rv0312 ^@ http://purl.uniprot.org/uniprot/O07239 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2523c ^@ http://purl.uniprot.org/uniprot/P9WQD3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Holo-[acyl-carrier-protein] synthase ^@ http://purl.uniprot.org/annotation/PRO_0000175675 http://togogenome.org/gene/83332:Rv0628c ^@ http://purl.uniprot.org/uniprot/P9WKS7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0628c ^@ http://purl.uniprot.org/annotation/PRO_0000103714 http://togogenome.org/gene/83332:Rv3761c ^@ http://purl.uniprot.org/uniprot/O69727 ^@ Region ^@ Domain Extent ^@ APH ^@ http://togogenome.org/gene/83332:Rv1155 ^@ http://purl.uniprot.org/uniprot/O06553 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ F420H(2)-dependent reductase Rv1155|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000399901 http://togogenome.org/gene/83332:Rv0915c ^@ http://purl.uniprot.org/uniprot/P9WI33 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE14 ^@ http://purl.uniprot.org/annotation/PRO_0000379586 http://togogenome.org/gene/83332:Rv0969 ^@ http://purl.uniprot.org/uniprot/P9WPS3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ 4-aspartylphosphate intermediate|||HMA|||Helical|||Probable copper-exporting P-type ATPase V ^@ http://purl.uniprot.org/annotation/PRO_0000046348 http://togogenome.org/gene/83332:Rv2152c ^@ http://purl.uniprot.org/uniprot/P9WJL7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ UDP-N-acetylmuramate--L-alanine ligase ^@ http://purl.uniprot.org/annotation/PRO_0000182120 http://togogenome.org/gene/83332:Rv1290c ^@ http://purl.uniprot.org/uniprot/P9WM35 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1290c ^@ http://purl.uniprot.org/annotation/PRO_0000103789 http://togogenome.org/gene/83332:Rv1823 ^@ http://purl.uniprot.org/uniprot/P9WFG1 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||UPF0749 protein Rv1823 ^@ http://purl.uniprot.org/annotation/PRO_0000014110 http://togogenome.org/gene/83332:Rv0933 ^@ http://purl.uniprot.org/uniprot/P9WQK9 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Sequence Conflict ^@ ABC transporter|||Phosphate import ATP-binding protein PstB 2 ^@ http://purl.uniprot.org/annotation/PRO_0000092850 http://togogenome.org/gene/83332:Rv2640c ^@ http://purl.uniprot.org/uniprot/I6Y1A7 ^@ Region ^@ Domain Extent ^@ HTH arsR-type ^@ http://togogenome.org/gene/83332:Rv2115c ^@ http://purl.uniprot.org/uniprot/P9WQN5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Coiled-Coil|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes proteasome substrate degradation and protection against RNI.|||Abolishes proteasome substrate degradation.|||Abolishes protection against RNI.|||Abolishes unfolding capacity.|||Does not dramatically affect proteasome substrate degradation.|||Impairs Mpa hexamerization; when associated with A-187 and E-235.|||Impairs Mpa hexamerization; when associated with E-173 and A-187.|||Impairs Mpa hexamerization; when associated with E-173 and E-235.|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||No effect on unfolding capacity.|||Proteasome-associated ATPase|||Reduces both ATPase activity and ATP affinity. Abolishes proteasome substrate degradation and protection against RNI.|||Retains ATPase and unfolding activities, yet abolishes proteasome substrate degradation and protection against RNI. Is also highly attenuated in mice.|||Severely reduces ATPase activity. Abolishes proteasome substrate degradation and protection against RNI.|||Severely reduces ATPase activity. Abolishes protection against RNI. ^@ http://purl.uniprot.org/annotation/PRO_0000084778 http://togogenome.org/gene/83332:Rv0616A ^@ http://purl.uniprot.org/uniprot/P9WJ37 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB29 ^@ http://purl.uniprot.org/annotation/PRO_0000408073 http://togogenome.org/gene/83332:Rv1123c ^@ http://purl.uniprot.org/uniprot/O06575 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv2819c ^@ http://purl.uniprot.org/uniprot/P9WJF5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||CRISPR system Cms protein Csm5 ^@ http://purl.uniprot.org/annotation/PRO_0000418228 http://togogenome.org/gene/83332:Rv1602 ^@ http://purl.uniprot.org/uniprot/P9WMM1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Glutamine amidotransferase type-1|||Imidazole glycerol phosphate synthase subunit HisH|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000152396 http://togogenome.org/gene/83332:Rv2470 ^@ http://purl.uniprot.org/uniprot/P9WN23 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Modified Residue|||Turn ^@ 3',4'-dihydroxyphenylalanine; alternate|||Group 2 truncated hemoglobin GlbO|||Isodityrosine (Tyr-Tyr); alternate|||proximal binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000162643 http://togogenome.org/gene/83332:Rv2783c ^@ http://purl.uniprot.org/uniprot/P9WI57 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ KH|||Polyribonucleotide nucleotidyltransferase|||S1 motif ^@ http://purl.uniprot.org/annotation/PRO_0000329724 http://togogenome.org/gene/83332:Rv0573c ^@ http://purl.uniprot.org/uniprot/P9WJI7 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ Nicotinate phosphoribosyltransferase pncB2|||Phosphohistidine ^@ http://purl.uniprot.org/annotation/PRO_0000392685 http://togogenome.org/gene/83332:Rv3295 ^@ http://purl.uniprot.org/uniprot/P96900 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2609c ^@ http://purl.uniprot.org/uniprot/I6YDV4 ^@ Region ^@ Domain Extent ^@ Nudix hydrolase ^@ http://togogenome.org/gene/83332:Rv3144c ^@ http://purl.uniprot.org/uniprot/I6X6H8 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||PPE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0506 ^@ http://purl.uniprot.org/uniprot/P9WJT3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport accessory protein MmpS2 ^@ http://purl.uniprot.org/annotation/PRO_0000216153 http://togogenome.org/gene/83332:Rv3114 ^@ http://purl.uniprot.org/uniprot/O05791 ^@ Region ^@ Domain Extent ^@ CMP/dCMP-type deaminase ^@ http://togogenome.org/gene/83332:Rv0005 ^@ http://purl.uniprot.org/uniprot/P9WG45 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Sequence Conflict|||Strand|||Turn ^@ 10% supercoiling, 7% decatenation.|||13% supercoiling, 10% decatenation, 42% DNA cleavage in presence of norfloxacin.|||15% supercoiling, 19% decatenation, 143% DNA cleavage in presence of norfloxacin.|||17-fold increased resistance to fluoroquinolones, slightly increased DNA cleavage in absence of drugs.|||18% supercoiling, 11% decatenation, 131% DNA cleavage in presence of norfloxacin.|||37% supercoiling, 54% decatenation, 126% DNA cleavage in presence of norfloxacin.|||<2% supercoiling, 2% decatenation.|||<2% supercoiling, 3% decatenation.|||<2% supercoiling, 4% decatenation.|||<3% supercoiling, 18% decatenation, 75% DNA cleavage in presence of norfloxacin.|||DNA gyrase subunit B|||Increased resistance to aminopyrazinamides, however genome not sequenced.|||Increased resistance to pyrrolamides and novobiocin, however genome not sequenced.|||Increased susceptibility to fluoroquinolones, half supercoiling activity, no fluoroquinolone-induced DNA cleavage (makes sequence more like E.coli).|||No supercoiling activity.|||Toprim ^@ http://purl.uniprot.org/annotation/PRO_0000145325 http://togogenome.org/gene/83332:Rv1705c ^@ http://purl.uniprot.org/uniprot/P9WI19 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE22 ^@ http://purl.uniprot.org/annotation/PRO_0000378478 http://togogenome.org/gene/83332:Rv0333 ^@ http://purl.uniprot.org/uniprot/O33273 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv1515c ^@ http://purl.uniprot.org/uniprot/P71794 ^@ Region ^@ Domain Extent ^@ Methyltranfer_dom ^@ http://togogenome.org/gene/83332:Rv3807c ^@ http://purl.uniprot.org/uniprot/P9WI53 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative decaprenylphosphoryl-5-phosphoribose phosphatase Rv3807c ^@ http://purl.uniprot.org/annotation/PRO_0000420590 http://togogenome.org/gene/83332:Rv0144 ^@ http://purl.uniprot.org/uniprot/P96821 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv3771c ^@ http://purl.uniprot.org/uniprot/P72038 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1338 ^@ http://purl.uniprot.org/uniprot/P9WPW9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Glutamate racemase|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000095489 http://togogenome.org/gene/83332:Rv2728c ^@ http://purl.uniprot.org/uniprot/I6X579 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010190149 http://togogenome.org/gene/83332:Rv0805 ^@ http://purl.uniprot.org/uniprot/P9WP65 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 2-fold increase in bis(pNPP) hydrolysis. 4-fold decrease in pNPP hydrolysis. 5-fold decrease in 2',3'-cAMP hydrolysis.|||25% decrease in bis(pNPP) hydrolysis. 70% decrease in cAMP hydrolysis. Decreases interaction with the cell wall.|||40% decrease in bis(pNPP) hydrolysis. 80% decrease in 3',5'-cAMP and 2',3'-cAMP hydrolysis.|||40% decrease in bis(pNPP) hydrolysis. Strong decrease in 3',5'-cAMP and 2',3'-cAMP hydrolysis. Abolishes pNPP hydrolysis. Decreases interaction with the cell wall.|||50% decrease in bis(pNPP) hydrolysis. Does not affect cAMP hydrolysis. Decreases interaction with the cell wall.|||50% decrease in bis(pNPP) hydrolysis. Does not affect cAMP hydrolysis. Strong decrease in interaction with the cell wall.|||75% decrease in bis(pNPP) hydrolysis. Does not affect cAMP hydrolysis. Decreases catalytic efficiency and shows lower affinity for both linear and cyclic substrates. Almost completely abrogates interaction with the cell wall in vitro.|||8-fold decrease in phosphorylation. Affects localization to the cell wall.|||80% decrease in hydrolysis of 3',5'-cAMP and bis(pNPP). 40% decrease in 2',3'-cAMP hydrolysis. Strong decrease in interaction with the cell wall.|||90% decrease in bis(pNPP) hydrolysis. Does not affect cAMP hydrolysis. Strong decrease in interaction with the cell wall.|||Does not affect localization to the cell wall.|||Loss of bis(pNPP) and 3',5'-cAMP hydrolysis. Strong decrease in 2',3'-cAMP hydrolysis. Slight decrease in interaction with the cell wall.|||No change in activity.|||Phosphothreonine|||cAMP/cGMP dual specificity phosphodiesterase Rv0805 ^@ http://purl.uniprot.org/annotation/PRO_0000413370 http://togogenome.org/gene/83332:Rv0451c ^@ http://purl.uniprot.org/uniprot/P9WJS9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Strand|||Transmembrane ^@ Helical|||Siderophore export accessory protein MmpS4 ^@ http://purl.uniprot.org/annotation/PRO_0000216158 http://togogenome.org/gene/83332:Rv2164c ^@ http://purl.uniprot.org/uniprot/O06213 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Polar residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1631 ^@ http://purl.uniprot.org/uniprot/P9WPA3 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ Almost loss of activity. Shows very poor binding to ATP.|||DPCK|||Decreases Km for both ATP and dephospho-CoA. Has minimal effect on kcat.|||Dephospho-CoA kinase|||Does not affect Km for ATP, but shows a 15-fold increase in the Km for dephospho-CoA. Decrease in kcat and strong decrease in catalytic efficiency.|||Does not affect Km for ATP, but shows a 2.5-fold increase in the Km for dephospho-CoA.|||Does not affect oligomerization.|||Does not change either the Km or the kcat of the reaction considerably.|||Increases Km for both ATP and dephospho-CoA, but increases the enzymatic turnover.|||Loss of activity.|||Shows a 50% increase in the Km for ATP and a 19% reduction in kcat. ^@ http://purl.uniprot.org/annotation/PRO_0000172964 http://togogenome.org/gene/83332:Rv3393 ^@ http://purl.uniprot.org/uniprot/O50418 ^@ Region ^@ Domain Extent ^@ IU_nuc_hydro ^@ http://togogenome.org/gene/83332:Rv0264c ^@ http://purl.uniprot.org/uniprot/P95221 ^@ Region ^@ Domain Extent ^@ AHS1 ^@ http://togogenome.org/gene/83332:Rv2494 ^@ http://purl.uniprot.org/uniprot/O53219 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribonuclease VapC38 ^@ http://purl.uniprot.org/annotation/PRO_0000407893 http://togogenome.org/gene/83332:Rv1461 ^@ http://purl.uniprot.org/uniprot/P9WFP7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ DOD-type homing endonuclease|||Endonuclease PI-MtuHIIP|||UPF0051 protein Rv1461, 1st part|||UPF0051 protein Rv1461, 2nd part ^@ http://purl.uniprot.org/annotation/PRO_0000036190|||http://purl.uniprot.org/annotation/PRO_0000036191|||http://purl.uniprot.org/annotation/PRO_0000036192 http://togogenome.org/gene/83332:Rv0091 ^@ http://purl.uniprot.org/uniprot/P9WJM3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000164446 http://togogenome.org/gene/83332:Rv2300c ^@ http://purl.uniprot.org/uniprot/P9WLD7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable metallo-hydrolase Rv2300c ^@ http://purl.uniprot.org/annotation/PRO_0000104009 http://togogenome.org/gene/83332:Rv3538 ^@ http://purl.uniprot.org/uniprot/Q6MWW2 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Enoyl-CoA hydratase ChsH3|||MaoC-like ^@ http://purl.uniprot.org/annotation/PRO_0000456534 http://togogenome.org/gene/83332:Rv0376c ^@ http://purl.uniprot.org/uniprot/O53711 ^@ Region ^@ Domain Extent ^@ XdhC_C|||XdhC_CoxI ^@ http://togogenome.org/gene/83332:Rv3502c ^@ http://purl.uniprot.org/uniprot/O53547 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Hydroxyacyl-CoA dehydrogenase ChsB1 ^@ http://purl.uniprot.org/annotation/PRO_0000456535 http://togogenome.org/gene/83332:Rv2133c ^@ http://purl.uniprot.org/uniprot/O06242 ^@ Molecule Processing ^@ Chain ^@ Protein Rv2133c ^@ http://purl.uniprot.org/annotation/PRO_0000456390 http://togogenome.org/gene/83332:Rv2231A ^@ http://purl.uniprot.org/uniprot/P0CV93 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Ribonuclease VapC16 ^@ http://purl.uniprot.org/annotation/PRO_0000407875 http://togogenome.org/gene/83332:Rv2955c ^@ http://purl.uniprot.org/uniprot/P95137 ^@ Region ^@ Domain Extent ^@ Methyltransf_21 ^@ http://togogenome.org/gene/83332:Rv3802c ^@ http://purl.uniprot.org/uniprot/O53581 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Disulfide Bond|||Helix|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ 2-fold decrease in kcat for 4-methylumbelliferyl heptanoate and loss of phopholipase A activity; when associated with C-132.|||2-fold decrease in kcat for 4-methylumbelliferyl heptanoate and loss of phopholipase A activity; when associated with C-288.|||Carboxylesterase/lipase Culp6|||Helical|||Loss of activity for both short- and long-chain substrates.|||Nucleophile|||Pro residues|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000450109 http://togogenome.org/gene/83332:Rv1032c ^@ http://purl.uniprot.org/uniprot/P96368 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Transmembrane ^@ HAMP|||Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Sensor histidine kinase TrcS ^@ http://purl.uniprot.org/annotation/PRO_0000451062 http://togogenome.org/gene/83332:Rv2428 ^@ http://purl.uniprot.org/uniprot/P9WQB7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Initiator Methionine|||Mutagenesis Site|||Strand|||Turn ^@ 50% reduction in oxidation activity of dithiothreitol and 60% reduction in oxidation of thiocyanate.|||50% reduction in oxidation activity of dithiothreitol and thiocyanate.|||Alkyl hydroperoxide reductase C|||Cysteine sulfenic acid (-SOH) intermediate|||In reconstituted in vitro system retains no enzyme activity.|||Interchain (with C-133 in AhpD); transient|||Interchain (with C-174); in linked form|||Interchain (with C-61); in linked form|||No enzyme activity.|||Removed|||Retains about 10% activity with tert-butylhydroperoxide. In reconstituted in vitro system retains 30% enzyme activity.|||Thioredoxin|||Very poor oxidation activity of dithiothreitol and thiocyanate. ^@ http://purl.uniprot.org/annotation/PRO_0000392913 http://togogenome.org/gene/83332:Rv2787 ^@ http://purl.uniprot.org/uniprot/O33329 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ CbiA|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3632 ^@ http://purl.uniprot.org/uniprot/I6YGT7 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0495c ^@ http://purl.uniprot.org/uniprot/P9WKU5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0495c ^@ http://purl.uniprot.org/annotation/PRO_0000103695 http://togogenome.org/gene/83332:Rv2246 ^@ http://purl.uniprot.org/uniprot/P9WQD7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 3-oxoacyl-[acyl-carrier-protein] synthase 2|||Decreases phosphorylation. Lack of phosphorylation; when associated with A-313.|||Decreases phosphorylation. Lack of phosphorylation; when associated with A-315.|||For beta-ketoacyl synthase activity|||Ketosynthase family 3 (KS3)|||Phosphomimetic mutant. Loss of acid-fast staining and reduced pathogenicity; when associated with D-313.|||Phosphomimetic mutant. Loss of acid-fast staining and reduced pathogenicity; when associated with D-315.|||Phosphothreonine ^@ http://purl.uniprot.org/annotation/PRO_0000180334 http://togogenome.org/gene/83332:Rv1165 ^@ http://purl.uniprot.org/uniprot/O06563 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Tr-type G ^@ http://togogenome.org/gene/83332:Rv0114 ^@ http://purl.uniprot.org/uniprot/P9WMV3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000209397 http://togogenome.org/gene/83332:Rv0982 ^@ http://purl.uniprot.org/uniprot/P9WGL1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Abolishes autophosphorylation as well as dephosphorylation of phospho-MprA.|||Cytoplasmic|||Extracellular|||HAMP|||Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Polar residues|||Signal transduction histidine-protein kinase/phosphatase MprB ^@ http://purl.uniprot.org/annotation/PRO_0000308440 http://togogenome.org/gene/83332:Rv3183 ^@ http://purl.uniprot.org/uniprot/O53333 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand ^@ H-T-H motif|||HTH cro/C1-type|||Putative antitoxin HigA3 ^@ http://purl.uniprot.org/annotation/PRO_0000432912 http://togogenome.org/gene/83332:Rv1833c ^@ http://purl.uniprot.org/uniprot/P9WMS1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ AB hydrolase-1|||Haloalkane dehalogenase 2|||Nucleophile|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000216769 http://togogenome.org/gene/83332:Rv1300 ^@ http://purl.uniprot.org/uniprot/P9WHV3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Release factor glutamine methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000157166 http://togogenome.org/gene/83332:Rv1473 ^@ http://purl.uniprot.org/uniprot/O53164 ^@ Region ^@ Coiled-Coil|||Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv1645c ^@ http://purl.uniprot.org/uniprot/P94979 ^@ Region ^@ Domain Extent ^@ MPAB_Lcp_cat ^@ http://togogenome.org/gene/83332:Rv1133c ^@ http://purl.uniprot.org/uniprot/P9WK07 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region ^@ 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase|||Polar residues|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000098641 http://togogenome.org/gene/83332:Rv1612 ^@ http://purl.uniprot.org/uniprot/P9WFX9 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||Removed|||Tryptophan synthase beta chain ^@ http://purl.uniprot.org/annotation/PRO_0000098969 http://togogenome.org/gene/83332:Rv2482c ^@ http://purl.uniprot.org/uniprot/P9WI61 ^@ Molecule Processing|||Region ^@ Chain|||Motif ^@ Glycerol-3-phosphate acyltransferase|||HXXXXD motif ^@ http://purl.uniprot.org/annotation/PRO_0000195225 http://togogenome.org/gene/83332:Rv3478 ^@ http://purl.uniprot.org/uniprot/Q6MWX1 ^@ Region ^@ Domain Extent ^@ PPE|||PPE-SVP ^@ http://togogenome.org/gene/83332:Rv3307 ^@ http://purl.uniprot.org/uniprot/P9WP01 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Purine nucleoside phosphorylase ^@ http://purl.uniprot.org/annotation/PRO_0000184544 http://togogenome.org/gene/83332:Rv2269c ^@ http://purl.uniprot.org/uniprot/P9WLF9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2269c ^@ http://purl.uniprot.org/annotation/PRO_0000103995 http://togogenome.org/gene/83332:Rv3130c ^@ http://purl.uniprot.org/uniprot/P9WKC9 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Modified Residue ^@ N-acetylmethionine|||Probable diacyglycerol O-acyltransferase tgs1|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000222916 http://togogenome.org/gene/83332:Rv0016c ^@ http://purl.uniprot.org/uniprot/P9WKD1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Helix|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Acyl-ester intermediate|||Can rescue the deletion mutant.|||Cannot rescue the deletion mutant.|||Cytoplasmic|||Helical; Signal-anchor for type II membrane protein|||Peptidoglycan D,D-transpeptidase PbpA|||Periplasmic ^@ http://purl.uniprot.org/annotation/PRO_0000343832 http://togogenome.org/gene/83332:Rv3458c ^@ http://purl.uniprot.org/uniprot/P9WH35 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ 30S ribosomal protein S4|||S4 RNA-binding ^@ http://purl.uniprot.org/annotation/PRO_0000132422 http://togogenome.org/gene/83332:Rv1788 ^@ http://purl.uniprot.org/uniprot/L7N649 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010346600 http://togogenome.org/gene/83332:Rv1252c ^@ http://purl.uniprot.org/uniprot/P9WK49 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Polar residues|||Pro residues|||Putative lipoprotein LprE|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018141 http://togogenome.org/gene/83332:Rv0156 ^@ http://purl.uniprot.org/uniprot/P96833 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||PNTB_4TM ^@ http://togogenome.org/gene/83332:Rv3275c ^@ http://purl.uniprot.org/uniprot/P9WHM1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ N5-carboxyaminoimidazole ribonucleotide mutase ^@ http://purl.uniprot.org/annotation/PRO_0000074977 http://togogenome.org/gene/83332:Rv0672 ^@ http://purl.uniprot.org/uniprot/I6X9J0 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||AidB_N ^@ http://togogenome.org/gene/83332:Rv0639 ^@ http://purl.uniprot.org/uniprot/P9WIU9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Strand|||Turn ^@ Transcription termination/antitermination protein NusG ^@ http://purl.uniprot.org/annotation/PRO_0000113936 http://togogenome.org/gene/83332:Rv0816c ^@ http://purl.uniprot.org/uniprot/I6Y8V2 ^@ Region ^@ Domain Extent ^@ Thioredoxin ^@ http://togogenome.org/gene/83332:Rv0463 ^@ http://purl.uniprot.org/uniprot/O53748 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2176 ^@ http://purl.uniprot.org/uniprot/P9WI63 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Decrease in autophosphorylation activity. Does not affect transphosphorylation activity.|||Does not affect autophosphorylation and transphosphorylation activities.|||Extracellular|||Helical|||Lack of kinase activity.|||Phosphothreonine; by autocatalysis|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknL|||Strong decrease in autophosphorylation activity. Lack of transphosphorylation activity. ^@ http://purl.uniprot.org/annotation/PRO_0000171226 http://togogenome.org/gene/83332:Rv1310 ^@ http://purl.uniprot.org/uniprot/P9WPU5 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ ATP synthase subunit beta|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000144455 http://togogenome.org/gene/83332:Rv1641 ^@ http://purl.uniprot.org/uniprot/P9WKJ9 ^@ Molecule Processing ^@ Chain ^@ Translation initiation factor IF-3 ^@ http://purl.uniprot.org/annotation/PRO_0000177546 http://togogenome.org/gene/83332:Rv0276 ^@ http://purl.uniprot.org/uniprot/O53682 ^@ Region ^@ Domain Extent ^@ MPAB_Lcp_cat ^@ http://togogenome.org/gene/83332:Rv3404c ^@ http://purl.uniprot.org/uniprot/P9WKZ3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||dTDP-4-amino-4,6-dideoxyglucose formyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000014151 http://togogenome.org/gene/83332:Rv0643c ^@ http://purl.uniprot.org/uniprot/P0CH91 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ Loss of O-methyltransferase activity.|||Methoxy mycolic acid synthase MmaA3 ^@ http://purl.uniprot.org/annotation/PRO_0000398362 http://togogenome.org/gene/83332:Rv1146 ^@ http://purl.uniprot.org/uniprot/O06546 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MMPL ^@ http://togogenome.org/gene/83332:Rv2312 ^@ http://purl.uniprot.org/uniprot/P9WLB9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2312 ^@ http://purl.uniprot.org/annotation/PRO_0000104022 http://togogenome.org/gene/83332:Rv0102 ^@ http://purl.uniprot.org/uniprot/P9WM63 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0102 ^@ http://purl.uniprot.org/annotation/PRO_0000103672 http://togogenome.org/gene/83332:Rv3607c ^@ http://purl.uniprot.org/uniprot/P9WNC5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mass|||Mutagenesis Site|||Strand ^@ Dihydroneopterin aldolase|||Protein no longer targeted to encapsulin nanocompartments.|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000168275 http://togogenome.org/gene/83332:Rv2829c ^@ http://purl.uniprot.org/uniprot/P71623 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC22 ^@ http://purl.uniprot.org/annotation/PRO_0000407881 http://togogenome.org/gene/83332:Rv2144c ^@ http://purl.uniprot.org/uniprot/O06231 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv2793c ^@ http://purl.uniprot.org/uniprot/P9WHP7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Nucleophile|||tRNA pseudouridine synthase B ^@ http://purl.uniprot.org/annotation/PRO_0000121872 http://togogenome.org/gene/83332:Rv2317 ^@ http://purl.uniprot.org/uniprot/L7N652 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv0038 ^@ http://purl.uniprot.org/uniprot/P9WFK5 ^@ Molecule Processing ^@ Chain ^@ UPF0301 protein Rv0038 ^@ http://purl.uniprot.org/annotation/PRO_0000214329 http://togogenome.org/gene/83332:Rv2965c ^@ http://purl.uniprot.org/uniprot/P9WPA5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand ^@ N-acetylthreonine|||Phosphopantetheine adenylyltransferase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000156242 http://togogenome.org/gene/83332:Rv1262c ^@ http://purl.uniprot.org/uniprot/P9WML1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Motif ^@ HIT|||Histidine triad motif|||Uncharacterized HIT-like protein Rv1262c ^@ http://purl.uniprot.org/annotation/PRO_0000109826 http://togogenome.org/gene/83332:Rv3815c ^@ http://purl.uniprot.org/uniprot/O07808 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||PlsC ^@ http://togogenome.org/gene/83332:Rv2440c ^@ http://purl.uniprot.org/uniprot/P9WMT1 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Mutagenesis Site ^@ Basic and acidic residues|||GTPase Obg|||No GTPase activity.|||OBG-type G|||OCT|||Obg ^@ http://purl.uniprot.org/annotation/PRO_0000386062 http://togogenome.org/gene/83332:Rv2797c ^@ http://purl.uniprot.org/uniprot/P71654 ^@ Region ^@ Coiled-Coil ^@ ^@ http://togogenome.org/gene/83332:Rv3285 ^@ http://purl.uniprot.org/uniprot/P96890 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ ATP-grasp|||Biotin carboxylation|||Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit|||Biotinyl-binding|||N6-biotinyllysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000452367 http://togogenome.org/gene/83332:Rv3644c ^@ http://purl.uniprot.org/uniprot/O06363 ^@ Region ^@ Coiled-Coil|||Domain Extent ^@ AAA ^@ http://togogenome.org/gene/83332:Rv2257c ^@ http://purl.uniprot.org/uniprot/O53531 ^@ Region ^@ Domain Extent ^@ Beta-lactamase ^@ http://togogenome.org/gene/83332:Rv3236c ^@ http://purl.uniprot.org/uniprot/L7N665 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Na_H_Exchanger ^@ http://togogenome.org/gene/83332:Rv3082c ^@ http://purl.uniprot.org/uniprot/P9WMJ3 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Sequence Conflict ^@ H-T-H motif|||HTH araC/xylS-type|||HTH-type transcriptional regulator VirS ^@ http://purl.uniprot.org/annotation/PRO_0000194592 http://togogenome.org/gene/83332:Rv1178 ^@ http://purl.uniprot.org/uniprot/O50434 ^@ Molecule Processing ^@ Chain ^@ Probable aminotransferase Rv1178 ^@ http://purl.uniprot.org/annotation/PRO_0000456392 http://togogenome.org/gene/83332:Rv0125 ^@ http://purl.uniprot.org/uniprot/O07175 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PDZ ^@ http://purl.uniprot.org/annotation/PRO_5010226728 http://togogenome.org/gene/83332:Rv0992c ^@ http://purl.uniprot.org/uniprot/O05575 ^@ Site ^@ Binding Site ^@ ^@ http://togogenome.org/gene/83332:Rv3197 ^@ http://purl.uniprot.org/uniprot/O53343 ^@ Region ^@ Domain Extent ^@ ABC1 ^@ http://togogenome.org/gene/83332:Rv1845c ^@ http://purl.uniprot.org/uniprot/P95164 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Helical|||Peptidase_M48 ^@ http://purl.uniprot.org/annotation/PRO_5010241336 http://togogenome.org/gene/83332:Rv1484 ^@ http://purl.uniprot.org/uniprot/P9WGR1 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 1500-fold decrease in catalytic activity while no effect on lipid substrate affinity.|||24-fold decrease in catalytic activity while no effect on lipid substrate affinity.|||Confers INH and ETH resistance. The mutant is 17 times more resistant to inhibition by the INH-NAD adduct. 5- to 6-fold decrease in affinity for NADH that results from a perturbation in the hydrogen-bonding network that stabilizes NADH binding. Nearly no effect on the velocity of the enzyme. Has no impact on the susceptibility to pyridomycin.|||Confers pyridomycin resistance. Has no impact on the susceptibility to isoniazid and moxifloxacin. 14-fold decrease in NADH affinity, while no effect on catalytic activity.|||Enoyl-[acyl-carrier-protein] reductase [NADH]|||Loss of enzyme's ability to bind NADH.|||No effect on catalytic activity.|||No effect on catalytic activity. Loss of phosphorylation. Does not alter growth of M.tuberculosis.|||No effect on the enzyme's catalytic ability or on its ability to bind NADH.|||Phosphothreonine|||Severely impairs catalytic activity, as a consequence of a reduced binding affinity to NADH. These single point mutations are lethal to M.tuberculosis. These mutants fail to complement growth and mycolic acid defects of an inhA-thermosensitive M.smegmatis strain, in a similar manner to what is observed following isoniazid treatment. ^@ http://purl.uniprot.org/annotation/PRO_0000054916 http://togogenome.org/gene/83332:Rv1657 ^@ http://purl.uniprot.org/uniprot/P9WPY9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Arginine repressor ^@ http://purl.uniprot.org/annotation/PRO_0000205104 http://togogenome.org/gene/83332:Rv2499c ^@ http://purl.uniprot.org/uniprot/I6Y9H2 ^@ Region ^@ Domain Extent ^@ MaoC-like ^@ http://togogenome.org/gene/83332:Rv3317 ^@ http://purl.uniprot.org/uniprot/O53369 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1959c ^@ http://purl.uniprot.org/uniprot/P9WHG7 ^@ Molecule Processing ^@ Chain ^@ Toxin ParE1 ^@ http://purl.uniprot.org/annotation/PRO_0000408372 http://togogenome.org/gene/83332:Rv3509c ^@ http://purl.uniprot.org/uniprot/O53554 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative acetolactate synthase large subunit IlvX ^@ http://purl.uniprot.org/annotation/PRO_0000396953 http://togogenome.org/gene/83332:Rv0026 ^@ http://purl.uniprot.org/uniprot/P9WMB1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Polar residues|||Uncharacterized protein Rv0026 ^@ http://purl.uniprot.org/annotation/PRO_0000103643 http://togogenome.org/gene/83332:Rv2282c ^@ http://purl.uniprot.org/uniprot/P9WMF3 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH lysR-type|||Uncharacterized HTH-type transcriptional regulator Rv2282c ^@ http://purl.uniprot.org/annotation/PRO_0000105814 http://togogenome.org/gene/83332:Rv3469c ^@ http://purl.uniprot.org/uniprot/O06334 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Oxaloacetate decarboxylase|||Pyruvate carboxyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000450804 http://togogenome.org/gene/83332:Rv1777 ^@ http://purl.uniprot.org/uniprot/P9WPL1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Cytochrome P450 144|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052307 http://togogenome.org/gene/83332:Rv1860 ^@ http://purl.uniprot.org/uniprot/P9WIR7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Glycosylation Site|||Helix|||Mass|||Repeat|||Signal Peptide|||Strand|||Turn ^@ 1|||2|||3|||Alanine and proline-rich secreted protein Apa|||Chemically or enzymatically deglycosylated protein.|||O-linked (Man) threonine|||O-linked (Man...) threonine|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000020745 http://togogenome.org/gene/83332:Rv3830c ^@ http://purl.uniprot.org/uniprot/P96248 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0438c ^@ http://purl.uniprot.org/uniprot/P9WJQ5 ^@ Molecule Processing ^@ Chain ^@ Molybdopterin molybdenumtransferase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000170992 http://togogenome.org/gene/83332:Rv0683 ^@ http://purl.uniprot.org/uniprot/P9WH29 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ 30S ribosomal protein S7 ^@ http://purl.uniprot.org/annotation/PRO_0000124306 http://togogenome.org/gene/83332:Rv0827c ^@ http://purl.uniprot.org/uniprot/O53838 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Mutagenesis Site ^@ H-T-H motif|||HTH arsR-type|||HTH-type transcriptional regulator KmtR|||No change in activity. Does not affect regulation by metal ions.|||No change in activity. Lack of regulation by metal ions. ^@ http://purl.uniprot.org/annotation/PRO_0000419178 http://togogenome.org/gene/83332:Rv1354c ^@ http://purl.uniprot.org/uniprot/P9WM13 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ EAL|||GAF|||GGDEF|||Uncharacterized protein Rv1354c ^@ http://purl.uniprot.org/annotation/PRO_0000103823 http://togogenome.org/gene/83332:Rv1004c ^@ http://purl.uniprot.org/uniprot/O05589 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010284890 http://togogenome.org/gene/83332:Rv0476 ^@ http://purl.uniprot.org/uniprot/P9WKW1 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0476 ^@ http://purl.uniprot.org/annotation/PRO_0000014071 http://togogenome.org/gene/83332:Rv1320c ^@ http://purl.uniprot.org/uniprot/P9WQ29 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Guanylate cyclase|||HAMP|||Helical|||Uncharacterized protein Rv1320c ^@ http://purl.uniprot.org/annotation/PRO_0000195756 http://togogenome.org/gene/83332:Rv3414c ^@ http://purl.uniprot.org/uniprot/P9WGG9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif ^@ ECF RNA polymerase sigma factor SigD|||H-T-H motif|||Polymerase core binding ^@ http://purl.uniprot.org/annotation/PRO_0000094023 http://togogenome.org/gene/83332:Rv0654 ^@ http://purl.uniprot.org/uniprot/P9WPR5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Carotenoid cleavage oxygenase ^@ http://purl.uniprot.org/annotation/PRO_0000420620 http://togogenome.org/gene/83332:Rv1157c ^@ http://purl.uniprot.org/uniprot/O06555 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide ^@ Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5010263075 http://togogenome.org/gene/83332:Rv3697A ^@ http://purl.uniprot.org/uniprot/P9WJ15 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB48 ^@ http://purl.uniprot.org/annotation/PRO_0000408085 http://togogenome.org/gene/83332:Rv2839c ^@ http://purl.uniprot.org/uniprot/P9WKK1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ Pro residues|||Translation initiation factor IF-2|||tr-type G ^@ http://purl.uniprot.org/annotation/PRO_0000137224 http://togogenome.org/gene/83332:Rv0952 ^@ http://purl.uniprot.org/uniprot/P9WGC7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Succinate--CoA ligase [ADP-forming] subunit alpha|||Tele-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000102796 http://togogenome.org/gene/83332:Rv2385 ^@ http://purl.uniprot.org/uniprot/Q79FE8 ^@ Region ^@ Domain Extent ^@ Abhydrolase_3 ^@ http://togogenome.org/gene/83332:Rv1814 ^@ http://purl.uniprot.org/uniprot/P9WNZ9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ C-5 sterol desaturase|||Fatty acid hydroxylase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000117041 http://togogenome.org/gene/83332:Rv2975c ^@ http://purl.uniprot.org/uniprot/P95120 ^@ Region ^@ Domain Extent ^@ DhaL ^@ http://togogenome.org/gene/83332:Rv0772 ^@ http://purl.uniprot.org/uniprot/P9WHM9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ATP-grasp|||Phosphoribosylamine--glycine ligase ^@ http://purl.uniprot.org/annotation/PRO_0000151464 http://togogenome.org/gene/83332:Rv1272c ^@ http://purl.uniprot.org/uniprot/P9WQJ3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||ABC transporter|||Fatty acid ABC transporter ATP-binding/permease protein|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000093261 http://togogenome.org/gene/83332:Rv2450c ^@ http://purl.uniprot.org/uniprot/O53177 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Signal Peptide|||Strand|||Turn ^@ Pro residues|||Resuscitation-promoting factor RpfE ^@ http://purl.uniprot.org/annotation/PRO_0000421031 http://togogenome.org/gene/83332:Rv3297 ^@ http://purl.uniprot.org/uniprot/P9WNC1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Initiator Methionine|||Zinc Finger ^@ Endonuclease 8 2|||FPG-type|||Proton donor|||Proton donor; for beta-elimination activity|||Proton donor; for delta-elimination activity|||Removed|||Schiff-base intermediate with DNA ^@ http://purl.uniprot.org/annotation/PRO_0000170901 http://togogenome.org/gene/83332:Rv3322c ^@ http://purl.uniprot.org/uniprot/L7N687 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv0172 ^@ http://purl.uniprot.org/uniprot/O07416 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD|||Pro residues ^@ http://togogenome.org/gene/83332:Rv3649 ^@ http://purl.uniprot.org/uniprot/O06359 ^@ Region ^@ Domain Extent ^@ Helicase ATP-binding|||Helicase C-terminal ^@ http://togogenome.org/gene/83332:Rv3092c ^@ http://purl.uniprot.org/uniprot/I6Y2I9 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0350 ^@ http://purl.uniprot.org/uniprot/P9WMJ9 ^@ Experimental Information|||Modification|||Molecule Processing ^@ Chain|||Modified Residue|||Sequence Conflict ^@ Chaperone protein DnaK|||Phosphothreonine; by autocatalysis ^@ http://purl.uniprot.org/annotation/PRO_0000078499 http://togogenome.org/gene/83332:Rv1188 ^@ http://purl.uniprot.org/uniprot/O50444 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Pro_dh ^@ http://togogenome.org/gene/83332:Rv0842 ^@ http://purl.uniprot.org/uniprot/O53854 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MFS ^@ http://togogenome.org/gene/83332:Rv2927c ^@ http://purl.uniprot.org/uniprot/P9WL15 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2927c ^@ http://purl.uniprot.org/annotation/PRO_0000104109 http://togogenome.org/gene/83332:Rv0176 ^@ http://purl.uniprot.org/uniprot/O07420 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||RDD ^@ http://togogenome.org/gene/83332:Rv3788 ^@ http://purl.uniprot.org/uniprot/P9WKW7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3788 ^@ http://purl.uniprot.org/annotation/PRO_0000104150 http://togogenome.org/gene/83332:Rv3424c ^@ http://purl.uniprot.org/uniprot/P9WKY3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3424c ^@ http://purl.uniprot.org/annotation/PRO_0000104135 http://togogenome.org/gene/83332:Rv0136 ^@ http://purl.uniprot.org/uniprot/P9WPM3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 138|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052298 http://togogenome.org/gene/83332:Rv0664 ^@ http://purl.uniprot.org/uniprot/O06775 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB8 ^@ http://purl.uniprot.org/annotation/PRO_0000408057 http://togogenome.org/gene/83332:Rv1855c ^@ http://purl.uniprot.org/uniprot/P95159 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv3617 ^@ http://purl.uniprot.org/uniprot/I6YGS0 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ AB hydrolase-1|||Epoxide hydrolase A|||Nucleophile|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000438585 http://togogenome.org/gene/83332:Rv2325c ^@ http://purl.uniprot.org/uniprot/P9WPI7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2325c ^@ http://purl.uniprot.org/annotation/PRO_0000104028 http://togogenome.org/gene/83332:Rv2509 ^@ http://purl.uniprot.org/uniprot/I6Y9I3 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2154c ^@ http://purl.uniprot.org/uniprot/P9WN97 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||Helical|||Polar residues|||Probable peptidoglycan glycosyltransferase FtsW ^@ http://purl.uniprot.org/annotation/PRO_0000062725 http://togogenome.org/gene/83332:Rv3331 ^@ http://purl.uniprot.org/uniprot/L0TDU1 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MFS ^@ http://togogenome.org/gene/83332:Rv1970 ^@ http://purl.uniprot.org/uniprot/O53971 ^@ Region ^@ Domain Extent ^@ Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv2330c ^@ http://purl.uniprot.org/uniprot/P9WK69 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppP|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018116 http://togogenome.org/gene/83332:Rv0755c ^@ http://purl.uniprot.org/uniprot/P9WI37 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE12 ^@ http://purl.uniprot.org/annotation/PRO_0000378476 http://togogenome.org/gene/83332:Rv2292c ^@ http://purl.uniprot.org/uniprot/P9WLE3 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2292c ^@ http://purl.uniprot.org/annotation/PRO_0000014128 http://togogenome.org/gene/83332:Rv2821c ^@ http://purl.uniprot.org/uniprot/P9WJF9 ^@ Molecule Processing ^@ Chain ^@ CRISPR system Cms endoribonuclease Csm3 ^@ http://purl.uniprot.org/annotation/PRO_0000418226 http://togogenome.org/gene/83332:Rv3153 ^@ http://purl.uniprot.org/uniprot/P9WJG9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ 4Fe-4S ferredoxin-type 1|||4Fe-4S ferredoxin-type 2|||NADH-quinone oxidoreductase subunit I ^@ http://purl.uniprot.org/annotation/PRO_0000118729 http://togogenome.org/gene/83332:Rv1796 ^@ http://purl.uniprot.org/uniprot/O53945 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Charge relay system|||Helical|||Mycosin-5|||Peptidase S8|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5007696963 http://togogenome.org/gene/83332:Rv2006 ^@ http://purl.uniprot.org/uniprot/P9WN15 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton donor|||Uncharacterized glycosyl hydrolase Rv2006 ^@ http://purl.uniprot.org/annotation/PRO_0000108019 http://togogenome.org/gene/83332:Rv3840 ^@ http://purl.uniprot.org/uniprot/P96238 ^@ Region ^@ Domain Extent ^@ LytR_cpsA_psr ^@ http://togogenome.org/gene/83332:Rv0492A ^@ http://purl.uniprot.org/uniprot/Q6MX36 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0694 ^@ http://purl.uniprot.org/uniprot/P9WND7 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ FMN hydroxy acid dehydrogenase|||Pre-mycofactocin synthase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000390892 http://togogenome.org/gene/83332:Rv1200 ^@ http://purl.uniprot.org/uniprot/O05301 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MFS ^@ http://togogenome.org/gene/83332:Rv1366 ^@ http://purl.uniprot.org/uniprot/P9WLZ5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1366 ^@ http://purl.uniprot.org/annotation/PRO_0000103834 http://togogenome.org/gene/83332:Rv2594c ^@ http://purl.uniprot.org/uniprot/P9WGV9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Crossover junction endodeoxyribonuclease RuvC ^@ http://purl.uniprot.org/annotation/PRO_0000183110 http://togogenome.org/gene/83332:Rv1014c ^@ http://purl.uniprot.org/uniprot/P9WHN7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Peptidyl-tRNA hydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000187780 http://togogenome.org/gene/83332:Rv2196 ^@ http://purl.uniprot.org/uniprot/P9WP37 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ Confers resistance to LPZS. Remains susceptible to IPA.|||Confers resistance to Q203 and IPA. Remains susceptible to LPZS.|||Cytochrome bc1 complex cytochrome b subunit|||Helical|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000061927 http://togogenome.org/gene/83332:Rv3812 ^@ http://purl.uniprot.org/uniprot/L7N680 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS62 ^@ http://purl.uniprot.org/annotation/PRO_0000451249 http://togogenome.org/gene/83332:Rv1992c ^@ http://purl.uniprot.org/uniprot/P9WPS7 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ 4-aspartylphosphate intermediate|||HMA|||Helical|||Probable cation-transporting ATPase G ^@ http://purl.uniprot.org/annotation/PRO_0000046345 http://togogenome.org/gene/83332:Rv2850c ^@ http://purl.uniprot.org/uniprot/P9WPR3 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Modified Residue ^@ N-acetylmethionine|||Polar residues|||Pro residues|||Uncharacterized protein Rv2850c|||VWFA ^@ http://purl.uniprot.org/annotation/PRO_0000206874 http://togogenome.org/gene/83332:Rv1490 ^@ http://purl.uniprot.org/uniprot/P9WLX1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1490 ^@ http://purl.uniprot.org/annotation/PRO_0000103856 http://togogenome.org/gene/83332:Rv0962c ^@ http://purl.uniprot.org/uniprot/P9WK39 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||S-diacylglycerol cysteine|||Uncharacterized lipoprotein LprP ^@ http://purl.uniprot.org/annotation/PRO_0000018152 http://togogenome.org/gene/83332:Rv2431c ^@ http://purl.uniprot.org/uniprot/I6X486 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylserine|||PE|||PE-PGRS family protein PE25|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000435110 http://togogenome.org/gene/83332:Rv1825 ^@ http://purl.uniprot.org/uniprot/P9WFG3 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Signal Peptide|||Strand|||Transmembrane ^@ Helical|||UPF0749 protein Rv1825 ^@ http://purl.uniprot.org/annotation/PRO_0000014112 http://togogenome.org/gene/83332:Rv3535c ^@ http://purl.uniprot.org/uniprot/P9WQH3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 2200-fold decrease in catalytic efficiency with coenzyme A.|||6600-fold decrease in catalytic efficiency with coenzyme A.|||Acyl-thioester intermediate|||Propanal dehydrogenase (CoA-propanoylating) ^@ http://purl.uniprot.org/annotation/PRO_0000387688 http://togogenome.org/gene/83332:Rv2985 ^@ http://purl.uniprot.org/uniprot/P9WIY3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ 8-oxo-(d)GTP phosphatase|||Nudix box|||Nudix hydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000391775 http://togogenome.org/gene/83332:Rv1628c ^@ http://purl.uniprot.org/uniprot/O06145 ^@ Region ^@ Domain Extent ^@ DUF35_N|||OB_aCoA_assoc ^@ http://togogenome.org/gene/83332:Rv1282c ^@ http://purl.uniprot.org/uniprot/P9WFZ9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Putative peptide transport permease protein Rv1282c ^@ http://purl.uniprot.org/annotation/PRO_0000060289 http://togogenome.org/gene/83332:Rv1458c ^@ http://purl.uniprot.org/uniprot/O53149 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv3395A ^@ http://purl.uniprot.org/uniprot/Q6MWX4 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010295883 http://togogenome.org/gene/83332:Rv0182c ^@ http://purl.uniprot.org/uniprot/P9WGG5 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Motif ^@ ECF RNA polymerase sigma factor SigG|||H-T-H motif|||Polymerase core binding ^@ http://purl.uniprot.org/annotation/PRO_0000423098 http://togogenome.org/gene/83332:Rv1939 ^@ http://purl.uniprot.org/uniprot/P95275 ^@ Region ^@ Domain Extent ^@ Flavin_Reduct ^@ http://togogenome.org/gene/83332:Rv3663c ^@ http://purl.uniprot.org/uniprot/I6Y482 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv3103c ^@ http://purl.uniprot.org/uniprot/O05780 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0363c ^@ http://purl.uniprot.org/uniprot/P9WQA3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Fructose-bisphosphate aldolase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000178722 http://togogenome.org/gene/83332:Rv0007 ^@ http://purl.uniprot.org/uniprot/P9WMA7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0007 ^@ http://purl.uniprot.org/annotation/PRO_0000103637 http://togogenome.org/gene/83332:Rv3473c ^@ http://purl.uniprot.org/uniprot/O06338 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv2937 ^@ http://purl.uniprot.org/uniprot/P9WG23 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-2|||Doxorubicin resistance ABC transporter permease protein DrrB|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393226 http://togogenome.org/gene/83332:Rv0186 ^@ http://purl.uniprot.org/uniprot/O07430 ^@ Region ^@ Domain Extent ^@ Fn3_like ^@ http://togogenome.org/gene/83332:Rv3799c ^@ http://purl.uniprot.org/uniprot/O53578 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Biotin-dependent long chain acyl-coenzyme A carboxylase beta4 subunit|||CoA carboxyltransferase C-terminal|||CoA carboxyltransferase N-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000452370 http://togogenome.org/gene/83332:Rv0674 ^@ http://purl.uniprot.org/uniprot/I6WZ26 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PaaX|||PaaX domain-containing protein, C-domain protein|||PaaX_C ^@ http://purl.uniprot.org/annotation/PRO_5010234064 http://togogenome.org/gene/83332:Rv0146 ^@ http://purl.uniprot.org/uniprot/P9WFJ3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0146 ^@ http://purl.uniprot.org/annotation/PRO_0000361236 http://togogenome.org/gene/83332:Rv3629c ^@ http://purl.uniprot.org/uniprot/O06378 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0481c ^@ http://purl.uniprot.org/uniprot/P9WKV5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0481c ^@ http://purl.uniprot.org/annotation/PRO_0000103683 http://togogenome.org/gene/83332:Rv0972c ^@ http://purl.uniprot.org/uniprot/P9WQG3 ^@ Molecule Processing ^@ Chain ^@ Acyl-CoA dehydrogenase FadE12 ^@ http://purl.uniprot.org/annotation/PRO_0000201185 http://togogenome.org/gene/83332:Rv1335 ^@ http://purl.uniprot.org/uniprot/P9WP33 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mass|||Modified Residue|||Strand|||Turn ^@ 1-thioglycine; alternate|||CysO-cysteine adduct.|||CysO-cysteine adduct; alternate|||Native form.|||Sulfur carrier protein CysO|||Thiocarboxylated form. ^@ http://purl.uniprot.org/annotation/PRO_0000159082 http://togogenome.org/gene/83332:Rv2520c ^@ http://purl.uniprot.org/uniprot/I6XEI0 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0797 ^@ http://purl.uniprot.org/uniprot/O07182 ^@ Region ^@ Domain Extent ^@ DEDD_Tnp_IS110 ^@ http://togogenome.org/gene/83332:Rv1980c ^@ http://purl.uniprot.org/uniprot/P9WIN9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Signal Peptide|||Strand|||Turn ^@ Immunogenic protein MPT64 ^@ http://purl.uniprot.org/annotation/PRO_0000021738 http://togogenome.org/gene/83332:Rv0848 ^@ http://purl.uniprot.org/uniprot/Q79FV4 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue|||Mutagenesis Site ^@ 10-fold decrease in the specificity constant for thiosulfate compared to wild-type enzyme but little change in the specificity constant for the substrate OPS.|||N6-(pyridoxal phosphate)lysine|||S-sulfocysteine synthase ^@ http://purl.uniprot.org/annotation/PRO_0000401201 http://togogenome.org/gene/83332:Rv3507 ^@ http://purl.uniprot.org/uniprot/Q6MWW9 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2637 ^@ http://purl.uniprot.org/uniprot/P9WP07 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein Rv2637 ^@ http://purl.uniprot.org/annotation/PRO_0000161430 http://togogenome.org/gene/83332:Rv3120 ^@ http://purl.uniprot.org/uniprot/O05796 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv0578c ^@ http://purl.uniprot.org/uniprot/Q6MX28 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5004278628 http://togogenome.org/gene/83332:Rv0373c ^@ http://purl.uniprot.org/uniprot/O53708 ^@ Region ^@ Domain Extent ^@ Ald_Xan_dh_C ^@ http://togogenome.org/gene/83332:Rv0704 ^@ http://purl.uniprot.org/uniprot/P9WHA5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 50S ribosomal protein L2|||Basic residues ^@ http://purl.uniprot.org/annotation/PRO_0000129587 http://togogenome.org/gene/83332:Rv2466c ^@ http://purl.uniprot.org/uniprot/O53193 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand ^@ Lack of activity. Confers resistance to TP053.|||Thioredoxin-like reductase Rv2466c ^@ http://purl.uniprot.org/annotation/PRO_0000433023 http://togogenome.org/gene/83332:Rv3302c ^@ http://purl.uniprot.org/uniprot/P9WN79 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Glycerol-3-phosphate dehydrogenase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000126102 http://togogenome.org/gene/83332:Rv2947c ^@ http://purl.uniprot.org/uniprot/P96284 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ For beta-ketoacyl synthase activity|||Ketosynthase family 3 (KS3)|||Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15 ^@ http://purl.uniprot.org/annotation/PRO_0000406363 http://togogenome.org/gene/83332:Rv0196 ^@ http://purl.uniprot.org/uniprot/P9WME1 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv0196 ^@ http://purl.uniprot.org/annotation/PRO_0000382632 http://togogenome.org/gene/83332:Rv1379 ^@ http://purl.uniprot.org/uniprot/P9WHK3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Motif|||Strand|||Turn ^@ Bifunctional protein PyrR|||PRPP-binding|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000183046 http://togogenome.org/gene/83332:Rv1866 ^@ http://purl.uniprot.org/uniprot/P95149 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Nucleophile|||Probable CoA-transferase Rv1866 ^@ http://purl.uniprot.org/annotation/PRO_0000432516 http://togogenome.org/gene/83332:Rv2038c ^@ http://purl.uniprot.org/uniprot/O53482 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv1679 ^@ http://purl.uniprot.org/uniprot/O53926 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv2863 ^@ http://purl.uniprot.org/uniprot/P9WF89 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC23 ^@ http://purl.uniprot.org/annotation/PRO_0000407882 http://togogenome.org/gene/83332:Rv2002 ^@ http://purl.uniprot.org/uniprot/P9WGT1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase|||Complete loss of both oxidation of androsterone and reduction of progesterone; when associated with T6; M-47 and K-69.|||Maximal improvement in solubility; when associated with M-47 and K-69.|||Maximal improvement in solubility; when associated with T-6 and K-69.|||Maximal improvement in solubility; when associated with T-6 and M-47.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000054712 http://togogenome.org/gene/83332:Rv0320 ^@ http://purl.uniprot.org/uniprot/O07246 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010182997 http://togogenome.org/gene/83332:Rv1500 ^@ http://purl.uniprot.org/uniprot/P9WMX5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative glycosyltransferases ^@ http://purl.uniprot.org/annotation/PRO_0000393107 http://togogenome.org/gene/83332:Rv2357c ^@ http://purl.uniprot.org/uniprot/P9WFV7 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue ^@ Glycine--tRNA ligase|||N6-acetyllysine ^@ http://purl.uniprot.org/annotation/PRO_0000072969 http://togogenome.org/gene/83332:Rv1835c ^@ http://purl.uniprot.org/uniprot/P9WIQ9 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-ester intermediate|||Charge relay system|||Putative serine esterase Rv1835c ^@ http://purl.uniprot.org/annotation/PRO_0000103908 http://togogenome.org/gene/83332:Rv3547 ^@ http://purl.uniprot.org/uniprot/P9WP15 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Deazaflavin-dependent nitroreductase|||Loss of PA-824 and menadione reductase activity.|||Loss of PA-824 reductase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000399507 http://togogenome.org/gene/83332:Rv0460 ^@ http://purl.uniprot.org/uniprot/O53745 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1324 ^@ http://purl.uniprot.org/uniprot/P9WG61 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Thioredoxin|||Uncharacterized protein Rv1324 ^@ http://purl.uniprot.org/annotation/PRO_0000014093 http://togogenome.org/gene/83332:Rv1292 ^@ http://purl.uniprot.org/uniprot/P9WFW5 ^@ Molecule Processing|||Region ^@ Chain|||Motif ^@ 'HIGH' region|||Arginine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000151580 http://togogenome.org/gene/83332:Rv2468A ^@ http://purl.uniprot.org/uniprot/I6YDH3 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0691A ^@ http://purl.uniprot.org/uniprot/P9WJ81 ^@ Molecule Processing ^@ Chain ^@ Mycofactocin precursor peptide ^@ http://purl.uniprot.org/annotation/PRO_0000415282 http://togogenome.org/gene/83332:Rv2297 ^@ http://purl.uniprot.org/uniprot/P9WLD9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2297 ^@ http://purl.uniprot.org/annotation/PRO_0000014131 http://togogenome.org/gene/83332:Rv0714 ^@ http://purl.uniprot.org/uniprot/P9WHD9 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L14 ^@ http://purl.uniprot.org/annotation/PRO_0000128554 http://togogenome.org/gene/83332:Rv3850 ^@ http://purl.uniprot.org/uniprot/P96227 ^@ Region ^@ Coiled-Coil ^@ ^@ http://togogenome.org/gene/83332:Rv3673c ^@ http://purl.uniprot.org/uniprot/I6YGW6 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Thioredoxin ^@ http://togogenome.org/gene/83332:Rv3488 ^@ http://purl.uniprot.org/uniprot/I6X7F9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand ^@ Abolishes cadmium and zinc binding.|||Transcriptional regulator Rv3488 ^@ http://purl.uniprot.org/annotation/PRO_0000447364 http://togogenome.org/gene/83332:Rv3810 ^@ http://purl.uniprot.org/uniprot/P9WIQ7 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region ^@ Chain|||Compositionally Biased Region|||Repeat|||Sequence Conflict|||Sequence Variant|||Signal Peptide|||Topological Domain|||Transmembrane ^@ 1-1|||1-2|||1-3|||1-4|||1-5|||1-6|||2-1|||2-2|||2-3|||2-4|||2-5|||2-6|||Cytoplasmic|||Exported repetitive protein|||Extracellular|||Helical|||In strain: MT103.|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000021201 http://togogenome.org/gene/83332:Rv0686 ^@ http://purl.uniprot.org/uniprot/I6XVZ6 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1768 ^@ http://purl.uniprot.org/uniprot/Q79FK9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5004287633 http://togogenome.org/gene/83332:Rv0050 ^@ http://purl.uniprot.org/uniprot/P71707 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Helix|||Strand|||Transmembrane|||Turn ^@ Acyl-ester intermediate; for transpeptidase activity|||Helical|||Penicillin-binding protein 1A|||Polar residues|||Pro residues|||Proton donor; for transglycosylase activity ^@ http://purl.uniprot.org/annotation/PRO_0000421124 http://togogenome.org/gene/83332:Rv1522c ^@ http://purl.uniprot.org/uniprot/P9WJT7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport protein MmpL12 ^@ http://purl.uniprot.org/annotation/PRO_0000103580 http://togogenome.org/gene/83332:Rv0153c ^@ http://purl.uniprot.org/uniprot/I6WXK4 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ Loss of activity.|||No change in activity.|||Phosphocysteine intermediate|||Shows less than 0.1% of wild-type activity with peptides substrates.|||Shows less than 1% of wild-type activity.|||Shows less than 1% of wild-type activity. Does not affect macrophage apoptosis.|||Shows less than 10% of the wild-type activity towards phosphotyrosine peptides, but remains unaltered towards pNPP and phosphoserine/threonine peptides.|||Shows new activity for di-phosphorylated substrates PI(3,4)P2, PI(4,5)P2 and PI(3,4,5)P3.|||Triple specificity protein phosphatase PtpB ^@ http://purl.uniprot.org/annotation/PRO_0000450734 http://togogenome.org/gene/83332:Rv0492c ^@ http://purl.uniprot.org/uniprot/P9WMV7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Uncharacterized GMC-type oxidoreductase Rv0492c ^@ http://purl.uniprot.org/annotation/PRO_0000205615 http://togogenome.org/gene/83332:Rv0985c ^@ http://purl.uniprot.org/uniprot/P9WJN5 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Strand|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||Helical|||Large-conductance mechanosensitive channel ^@ http://purl.uniprot.org/annotation/PRO_0000192452 http://togogenome.org/gene/83332:Rv1346 ^@ http://purl.uniprot.org/uniprot/P9WQF9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Acyl-[acyl-carrier-protein] dehydrogenase MbtN ^@ http://purl.uniprot.org/annotation/PRO_0000000538 http://togogenome.org/gene/83332:Rv2530c ^@ http://purl.uniprot.org/uniprot/P9WF63 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC39 ^@ http://purl.uniprot.org/annotation/PRO_0000407894 http://togogenome.org/gene/83332:Rv1175c ^@ http://purl.uniprot.org/uniprot/O50431 ^@ Region ^@ Domain Extent ^@ Oxidored_FMN|||Pyr_redox_2 ^@ http://togogenome.org/gene/83332:Rv0807 ^@ http://purl.uniprot.org/uniprot/I6Y8U3 ^@ Region ^@ Domain Extent ^@ SCP_3 ^@ http://togogenome.org/gene/83332:Rv3758c ^@ http://purl.uniprot.org/uniprot/O69724 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv0949 ^@ http://purl.uniprot.org/uniprot/P9WMQ1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue|||Mutagenesis Site ^@ ATP-dependent DNA helicase UvrD1|||Loss of ATPase and DNA unwinding, partially inhibits DNA strand exchange.|||N-acetylserine|||Removed|||UvrD-like helicase ATP-binding|||UvrD-like helicase C-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000102055 http://togogenome.org/gene/83332:Rv0989c ^@ http://purl.uniprot.org/uniprot/O05572 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif|||Mutagenesis Site ^@ DDXXD motif|||Dimethylallyltranstransferase|||Leads to the production of longer chain product, specifically (E,E)-farnesyl diphosphate (FPP), in addition to GPP. ^@ http://purl.uniprot.org/annotation/PRO_0000451294 http://togogenome.org/gene/83332:Rv1638 ^@ http://purl.uniprot.org/uniprot/P9WQK7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn|||Zinc Finger ^@ ABC transporter 1|||ABC transporter 2|||C4-type|||C4-type; atypical|||UvrABC system protein A ^@ http://purl.uniprot.org/annotation/PRO_0000093070 http://togogenome.org/gene/83332:Rv3694c ^@ http://purl.uniprot.org/uniprot/O69662 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1469 ^@ http://purl.uniprot.org/uniprot/P9WPT3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Helical|||Probable cobalt/nickel-exporting P-type ATPase ^@ http://purl.uniprot.org/annotation/PRO_0000046339 http://togogenome.org/gene/83332:Rv3133c ^@ http://purl.uniprot.org/uniprot/P9WMF9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 4-aspartylphosphate|||Able to bind DNA, no longer induces hypoxic response.|||DNA-binding transcriptional activator DevR/DosR|||Decreases phosphorylation by PknH.|||H-T-H motif|||HTH luxR-type|||No longer induces expression of DevR regulon under hypoxic conditions, phosphorylated slowly and incompletely by DevS, decreased cooperative binding of target DNA.|||No phosphorylation by DevS (DosS) nor by DosT.|||No phosphorylation by DevS (DosS).|||No phosphorylation by PknH.|||Phosphothreonine; by PknH|||Response regulatory ^@ http://purl.uniprot.org/annotation/PRO_0000392625 http://togogenome.org/gene/83332:Rv3513c ^@ http://purl.uniprot.org/uniprot/I6YGC8 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ AMP-binding_C|||Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0385 ^@ http://purl.uniprot.org/uniprot/Q7ARS9 ^@ Region ^@ Domain Extent ^@ FAD-binding FR-type ^@ http://togogenome.org/gene/83332:Rv2140c ^@ http://purl.uniprot.org/uniprot/P9WFN1 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylthreonine|||Removed|||UPF0098 protein Rv2140c ^@ http://purl.uniprot.org/annotation/PRO_0000137909 http://togogenome.org/gene/83332:Rv2477c ^@ http://purl.uniprot.org/uniprot/P9WQK3 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Domain Extent|||Helix|||Strand|||Turn ^@ ABC transporter 1|||ABC transporter 2|||Energy-dependent translational throttle protein EttA|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000395861 http://togogenome.org/gene/83332:Rv3314c ^@ http://purl.uniprot.org/uniprot/P9WFS1 ^@ Molecule Processing ^@ Chain ^@ Thymidine phosphorylase ^@ http://purl.uniprot.org/annotation/PRO_0000059082 http://togogenome.org/gene/83332:Rv2957 ^@ http://purl.uniprot.org/uniprot/P9WMX7 ^@ Molecule Processing ^@ Chain ^@ PGL/p-HBAD biosynthesis glycosyltransferase Rv2957 ^@ http://purl.uniprot.org/annotation/PRO_0000059251 http://togogenome.org/gene/83332:Rv0206c ^@ http://purl.uniprot.org/uniprot/P9WJV5 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Helix|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Confers resistance to BM212.|||Confers resistance to C215.|||Confers resistance to SQ109.|||Confers resistance to indoleamides.|||Cytoplasmic|||Helical|||Increases resistance to AU1235.|||Periplasmic|||Polar residues|||Trehalose monomycolate exporter MmpL3 ^@ http://purl.uniprot.org/annotation/PRO_0000103564 http://togogenome.org/gene/83332:Rv3139 ^@ http://purl.uniprot.org/uniprot/P95187 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv3641c ^@ http://purl.uniprot.org/uniprot/I6YCN3 ^@ Region ^@ Domain Extent ^@ Fido ^@ http://togogenome.org/gene/83332:Rv0502 ^@ http://purl.uniprot.org/uniprot/P9WKT1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0502 ^@ http://purl.uniprot.org/annotation/PRO_0000103709 http://togogenome.org/gene/83332:Rv2048c ^@ http://purl.uniprot.org/uniprot/I6XD69 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Coiled-Coil|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ Acyl-ester intermediate; for acyltransferase 1 activity|||Acyl-ester intermediate; for acyltransferase 2 activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase 1 activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase 2 activity|||Carrier 1|||Carrier 2|||For beta-ketoacyl reductase 1 activity|||For beta-ketoacyl reductase 2 activity|||For beta-ketoacyl synthase 1 activity|||For beta-ketoacyl synthase 2 activity|||Ketosynthase family 3 (KS3) 1|||Ketosynthase family 3 (KS3) 2|||Loss of activity.|||Mycoketide-CoA synthase|||O-(pantetheine 4'-phosphoryl)serine ^@ http://purl.uniprot.org/annotation/PRO_0000451583 http://togogenome.org/gene/83332:Rv1689 ^@ http://purl.uniprot.org/uniprot/P9WFT1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Motif|||Strand|||Turn ^@ 'HIGH' region|||'KMSKS' region|||S4 RNA-binding|||Tyrosine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000055660 http://togogenome.org/gene/83332:Rv0330c ^@ http://purl.uniprot.org/uniprot/O07254 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1512 ^@ http://purl.uniprot.org/uniprot/P71791 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ Epimerase|||Proton donor/acceptor ^@ http://togogenome.org/gene/83332:Rv2369c ^@ http://purl.uniprot.org/uniprot/L0TC46 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0473 ^@ http://purl.uniprot.org/uniprot/I6Y3V3 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3557c ^@ http://purl.uniprot.org/uniprot/P9WMB9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand|||Turn ^@ H-T-H motif|||HTH tetR-type|||HTH-type transcriptional repressor KstR2 ^@ http://purl.uniprot.org/annotation/PRO_0000405031 http://togogenome.org/gene/83332:Rv2591 ^@ http://purl.uniprot.org/uniprot/P9WIE9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||Uncharacterized PE-PGRS family protein PE_PGRS44 ^@ http://purl.uniprot.org/annotation/PRO_0000216169 http://togogenome.org/gene/83332:Rv2173 ^@ http://purl.uniprot.org/uniprot/O53507 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ (2E,6E)-farnesyl diphosphate synthase|||DDXXD motif ^@ http://purl.uniprot.org/annotation/PRO_0000451295 http://togogenome.org/gene/83332:Rv2334 ^@ http://purl.uniprot.org/uniprot/P9WP55 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||O-acetylserine sulfhydrylase ^@ http://purl.uniprot.org/annotation/PRO_0000167094 http://togogenome.org/gene/83332:Rv2659c ^@ http://purl.uniprot.org/uniprot/P9WMB3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Core-binding (CB)|||O-(3'-phospho-DNA)-tyrosine intermediate|||Putative prophage phiRv2 integrase|||Tyr recombinase ^@ http://purl.uniprot.org/annotation/PRO_0000392940 http://togogenome.org/gene/83332:Rv1143 ^@ http://purl.uniprot.org/uniprot/O06543 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 10.1% of wild-type activity.|||12.5% of wild-type activity.|||15.7% of wild-type activity.|||17.6 of wild-type activity.|||19.9% of wild-type activity.|||2.1% of wild-type activity.|||28.8% of wild-type activity.|||3.3% of wild-type activity.|||4.5% of wild-type activity.|||5.2% of wild-type activity.|||6.2% of wild-type activity.|||Alpha-methylacyl-CoA racemase|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000449922 http://togogenome.org/gene/83332:Rv1996 ^@ http://purl.uniprot.org/uniprot/P9WLP1 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Universal stress protein Rv1996 ^@ http://purl.uniprot.org/annotation/PRO_0000103924 http://togogenome.org/gene/83332:Rv2308 ^@ http://purl.uniprot.org/uniprot/P9WLC5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2308 ^@ http://purl.uniprot.org/annotation/PRO_0000104017 http://togogenome.org/gene/83332:Rv1961 ^@ http://purl.uniprot.org/uniprot/P95253 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv3684 ^@ http://purl.uniprot.org/uniprot/O69652 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ L-cysteine desulfhydrase Cds1|||N6-(pyridoxal phosphate)lysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000456520 http://togogenome.org/gene/83332:Rv3498c ^@ http://purl.uniprot.org/uniprot/I6X7G8 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv2628 ^@ http://purl.uniprot.org/uniprot/P9WL65 ^@ Molecule Processing ^@ Chain ^@ Putative uncharacterized protein Rv2628 ^@ http://purl.uniprot.org/annotation/PRO_0000393358 http://togogenome.org/gene/83332:Rv1392 ^@ http://purl.uniprot.org/uniprot/P9WGV1 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Strand|||Turn ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||S-adenosylmethionine synthase|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000174557 http://togogenome.org/gene/83332:Rv1802 ^@ http://purl.uniprot.org/uniprot/P9WI07 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE30 ^@ http://purl.uniprot.org/annotation/PRO_0000217848 http://togogenome.org/gene/83332:Rv1532c ^@ http://purl.uniprot.org/uniprot/O06178 ^@ Region ^@ Domain Extent ^@ 4HBT ^@ http://togogenome.org/gene/83332:Rv0168 ^@ http://purl.uniprot.org/uniprot/L0T2Q9 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3282 ^@ http://purl.uniprot.org/uniprot/P9WK27 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Nucleoside triphosphate pyrophosphatase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000123030 http://togogenome.org/gene/83332:Rv1029 ^@ http://purl.uniprot.org/uniprot/P9WKF3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Potassium-transporting ATPase potassium-binding subunit ^@ http://purl.uniprot.org/annotation/PRO_0000166509 http://togogenome.org/gene/83332:Rv0996 ^@ http://purl.uniprot.org/uniprot/O05579 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1356c ^@ http://purl.uniprot.org/uniprot/P9WM09 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1356c ^@ http://purl.uniprot.org/annotation/PRO_0000103826 http://togogenome.org/gene/83332:Rv0818 ^@ http://purl.uniprot.org/uniprot/O53830 ^@ Region ^@ DNA Binding|||Domain Extent ^@ OmpR/PhoB-type ^@ http://togogenome.org/gene/83332:Rv1039c ^@ http://purl.uniprot.org/uniprot/P9WI31 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ PPE family protein PPE15 ^@ http://purl.uniprot.org/annotation/PRO_0000378477 http://togogenome.org/gene/83332:Rv1649 ^@ http://purl.uniprot.org/uniprot/P9WFU3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Phenylalanine--tRNA ligase alpha subunit ^@ http://purl.uniprot.org/annotation/PRO_0000126733 http://togogenome.org/gene/83332:Rv1481 ^@ http://purl.uniprot.org/uniprot/P9WFJ7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||UPF0353 protein Rv1481|||VWFA ^@ http://purl.uniprot.org/annotation/PRO_0000057648 http://togogenome.org/gene/83332:Rv3704c ^@ http://purl.uniprot.org/uniprot/P9WPK7 ^@ Molecule Processing ^@ Chain ^@ Glutamate--cysteine ligase EgtA ^@ http://purl.uniprot.org/annotation/PRO_0000413646 http://togogenome.org/gene/83332:Rv2320c ^@ http://purl.uniprot.org/uniprot/P71892 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3180c ^@ http://purl.uniprot.org/uniprot/P9WF51 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribonuclease VapC49 ^@ http://purl.uniprot.org/annotation/PRO_0000407897 http://togogenome.org/gene/83332:Rv1297 ^@ http://purl.uniprot.org/uniprot/P9WHF3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||Polar residues|||Rho RNA-BD|||Transcription termination factor Rho ^@ http://purl.uniprot.org/annotation/PRO_0000188970 http://togogenome.org/gene/83332:Rv0397 ^@ http://purl.uniprot.org/uniprot/P95205 ^@ Region ^@ Compositionally Biased Region ^@ Pro residues ^@ http://togogenome.org/gene/83332:Rv2151c ^@ http://purl.uniprot.org/uniprot/P9WNA1 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Initiator Methionine|||Modified Residue|||Topological Domain|||Transmembrane ^@ Cell division protein FtsQ|||Cytoplasmic|||Extracellular|||Helical|||N-acetylthreonine|||POTRA|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000160582 http://togogenome.org/gene/83332:Rv3328c ^@ http://purl.uniprot.org/uniprot/L0TCG5 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif|||Strand|||Turn ^@ ECF RNA polymerase sigma factor SigJ|||H-T-H motif|||Polymerase core binding ^@ http://purl.uniprot.org/annotation/PRO_0000423648 http://togogenome.org/gene/83332:Rv2967c ^@ http://purl.uniprot.org/uniprot/I6YEU0 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ ATP-grasp|||Biotin carboxylation|||Lipoyl-binding|||Pyruvate carboxyltransferase|||via carbamate group ^@ http://togogenome.org/gene/83332:Rv0217c ^@ http://purl.uniprot.org/uniprot/P96399 ^@ Region ^@ Domain Extent ^@ Abhydrolase_3 ^@ http://togogenome.org/gene/83332:Rv3823c ^@ http://purl.uniprot.org/uniprot/P9WJU5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Sulfolipid-1 exporter MmpL8 ^@ http://purl.uniprot.org/annotation/PRO_0000103572 http://togogenome.org/gene/83332:Rv1058 ^@ http://purl.uniprot.org/uniprot/O53406 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv0023 ^@ http://purl.uniprot.org/uniprot/P9WMI3 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH cro/C1-type|||Uncharacterized HTH-type transcriptional regulator Rv0023 ^@ http://purl.uniprot.org/annotation/PRO_0000149772 http://togogenome.org/gene/83332:Rv0514 ^@ http://purl.uniprot.org/uniprot/O33359 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2266 ^@ http://purl.uniprot.org/uniprot/P9WPP3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Methyl-branched lipid omega-hydroxylase|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052278 http://togogenome.org/gene/83332:Rv0880 ^@ http://purl.uniprot.org/uniprot/P9WMF1 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ HTH marR-type|||Uncharacterized HTH-type transcriptional regulator Rv0880 ^@ http://purl.uniprot.org/annotation/PRO_0000054407 http://togogenome.org/gene/83332:Rv2059 ^@ http://purl.uniprot.org/uniprot/O07257 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues|||Basic residues ^@ http://togogenome.org/gene/83332:Rv3455c ^@ http://purl.uniprot.org/uniprot/P9WHP9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Nucleophile|||tRNA pseudouridine synthase A ^@ http://purl.uniprot.org/annotation/PRO_0000057415 http://togogenome.org/gene/83332:Rv3827c ^@ http://purl.uniprot.org/uniprot/O07796 ^@ Region ^@ Domain Extent ^@ HTH_OrfB_IS605|||OrfB_IS605 ^@ http://togogenome.org/gene/83332:Rv0691c ^@ http://purl.uniprot.org/uniprot/P9WMB7 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||Putative mycofactocin biosynthesis transcriptional regulator MftR ^@ http://purl.uniprot.org/annotation/PRO_0000415280 http://togogenome.org/gene/83332:Rv0341 ^@ http://purl.uniprot.org/uniprot/P9WJ97 ^@ Molecule Processing ^@ Chain ^@ Isoniazid-induced protein IniB ^@ http://purl.uniprot.org/annotation/PRO_0000390792 http://togogenome.org/gene/83332:Rv3272 ^@ http://purl.uniprot.org/uniprot/P96877 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Nucleophile|||Probable fatty acyl-CoA transferase Rv3272 ^@ http://purl.uniprot.org/annotation/PRO_0000447345 http://togogenome.org/gene/83332:Rv1185c ^@ http://purl.uniprot.org/uniprot/P9WQ49 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Putative fatty-acid--CoA ligase FadD21 ^@ http://purl.uniprot.org/annotation/PRO_0000193136 http://togogenome.org/gene/83332:Rv2380c ^@ http://purl.uniprot.org/uniprot/I6Y0L1 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Carrier|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0483 ^@ http://purl.uniprot.org/uniprot/P9WKV3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ L,D-transpeptidase 5|||Nucleophile|||Proton donor/acceptor|||YkuD ^@ http://purl.uniprot.org/annotation/PRO_0000430359 http://togogenome.org/gene/83332:Rv2682c ^@ http://purl.uniprot.org/uniprot/P9WNS3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 1-deoxy-D-xylulose-5-phosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000189130 http://togogenome.org/gene/83332:Rv3204 ^@ http://purl.uniprot.org/uniprot/O05862 ^@ Region ^@ Domain Extent ^@ DNA_binding_1 ^@ http://togogenome.org/gene/83332:Rv1001 ^@ http://purl.uniprot.org/uniprot/P9WQ05 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Amidino-cysteine intermediate|||Arginine deiminase ^@ http://purl.uniprot.org/annotation/PRO_0000182223 http://togogenome.org/gene/83332:Rv2183c ^@ http://purl.uniprot.org/uniprot/O53517 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv2671 ^@ http://purl.uniprot.org/uniprot/P71968 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ RibD_C ^@ http://togogenome.org/gene/83332:Rv3026c ^@ http://purl.uniprot.org/uniprot/I6XFY8 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||PlsC ^@ http://togogenome.org/gene/83332:Rv1664 ^@ http://purl.uniprot.org/uniprot/O06586 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv2007c ^@ http://purl.uniprot.org/uniprot/P9WNE7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ 4Fe-4S ferredoxin-type|||Ferredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000159099 http://togogenome.org/gene/83332:Rv2846c ^@ http://purl.uniprot.org/uniprot/P9WJY5 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Sequence Conflict|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||Helical|||Uncharacterized MFS-type transporter EfpA ^@ http://purl.uniprot.org/annotation/PRO_0000390888 http://togogenome.org/gene/83332:Rv1972 ^@ http://purl.uniprot.org/uniprot/O53973 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2501c ^@ http://purl.uniprot.org/uniprot/P9WPQ3 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Crosslink|||Domain Extent|||Modified Residue ^@ ATP-grasp|||Biotin carboxylation|||Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit|||Biotinyl-binding|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N6-biotinyllysine ^@ http://purl.uniprot.org/annotation/PRO_0000146798 http://togogenome.org/gene/83332:Rv2675c ^@ http://purl.uniprot.org/uniprot/I6Y1G8 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv3590c ^@ http://purl.uniprot.org/uniprot/I6XHM5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5003706422 http://togogenome.org/gene/83332:Rv2639c ^@ http://purl.uniprot.org/uniprot/P9WFN9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||UPF0060 membrane protein Rv2639c ^@ http://purl.uniprot.org/annotation/PRO_0000162333 http://togogenome.org/gene/83332:Rv1405c ^@ http://purl.uniprot.org/uniprot/P9WLY7 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1405c ^@ http://purl.uniprot.org/annotation/PRO_0000014103 http://togogenome.org/gene/83332:Rv0034 ^@ http://purl.uniprot.org/uniprot/P9WM93 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0034 ^@ http://purl.uniprot.org/annotation/PRO_0000103650 http://togogenome.org/gene/83332:Rv3150 ^@ http://purl.uniprot.org/uniprot/P9WIV7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ NADH-quinone oxidoreductase subunit F ^@ http://purl.uniprot.org/annotation/PRO_0000118574 http://togogenome.org/gene/83332:Rv1918c ^@ http://purl.uniprot.org/uniprot/Q79FI8 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv2070c ^@ http://purl.uniprot.org/uniprot/P9WP89 ^@ Molecule Processing ^@ Chain ^@ Precorrin-6A reductase ^@ http://purl.uniprot.org/annotation/PRO_0000135919 http://togogenome.org/gene/83332:Rv3367 ^@ http://purl.uniprot.org/uniprot/L0TCB8 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5003948349 http://togogenome.org/gene/83332:Rv0179c ^@ http://purl.uniprot.org/uniprot/O07423 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ NAGPA ^@ http://purl.uniprot.org/annotation/PRO_5010317646 http://togogenome.org/gene/83332:Rv3292 ^@ http://purl.uniprot.org/uniprot/P9WL01 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3292 ^@ http://purl.uniprot.org/annotation/PRO_0000104114 http://togogenome.org/gene/83332:Rv1368 ^@ http://purl.uniprot.org/uniprot/P9WK47 ^@ Experimental Information|||Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Mass|||Mutagenesis Site|||Signal Peptide ^@ Expressed in M.bovis, lipidated and glycosylated.|||N-palmitoyl cysteine|||No longer increases KdpD induction at 0 and 250 uM K(+); when associated with S-185 and V-197.|||No longer increases KdpD induction at 0 and 250 uM K(+); when associated with T-132 and S-185.|||No longer increases KdpD induction at 0 and 250 uM K(+); when associated with T-132 and V-197.|||Putative diacylated glycolipid transporter LprF|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018143 http://togogenome.org/gene/83332:Rv0004 ^@ http://purl.uniprot.org/uniprot/P9WFL1 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Sequence Conflict ^@ Basic and acidic residues|||UPF0232 protein Rv0004 ^@ http://purl.uniprot.org/annotation/PRO_0000211365 http://togogenome.org/gene/83332:Rv0838 ^@ http://purl.uniprot.org/uniprot/O53850 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Signal Peptide ^@ D-alanyl-D-alanine dipeptidase|||Polar residues|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_5030174835 http://togogenome.org/gene/83332:Rv1694 ^@ http://purl.uniprot.org/uniprot/P9WJ63 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA|||S4 RNA-binding ^@ http://purl.uniprot.org/annotation/PRO_0000415501 http://togogenome.org/gene/83332:Rv2193 ^@ http://purl.uniprot.org/uniprot/P9WP67 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ Helical|||N-acetylthreonine|||Probable cytochrome c oxidase subunit 3|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000183884 http://togogenome.org/gene/83332:Rv1660 ^@ http://purl.uniprot.org/uniprot/P9WPF5 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Polyketide synthase-like Pks10 ^@ http://purl.uniprot.org/annotation/PRO_0000406360 http://togogenome.org/gene/83332:Rv0661c ^@ http://purl.uniprot.org/uniprot/P9WFB3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC7 ^@ http://purl.uniprot.org/annotation/PRO_0000407870 http://togogenome.org/gene/83332:Rv1852 ^@ http://purl.uniprot.org/uniprot/P9WFE3 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Disulfide Bond ^@ Interchain|||Urease accessory protein UreG ^@ http://purl.uniprot.org/annotation/PRO_0000067669 http://togogenome.org/gene/83332:Rv2019 ^@ http://purl.uniprot.org/uniprot/O53465 ^@ Molecule Processing ^@ Chain ^@ Putative ribonuclease VapC45 ^@ http://purl.uniprot.org/annotation/PRO_0000433056 http://togogenome.org/gene/83332:Rv1492 ^@ http://purl.uniprot.org/uniprot/P9WJK7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Probable methylmalonyl-CoA mutase small subunit ^@ http://purl.uniprot.org/annotation/PRO_0000194265 http://togogenome.org/gene/83332:Rv2333c ^@ http://purl.uniprot.org/uniprot/P9WG91 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Multidrug resistance protein Stp ^@ http://purl.uniprot.org/annotation/PRO_0000390886 http://togogenome.org/gene/83332:Rv3194c ^@ http://purl.uniprot.org/uniprot/O53340 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Signal Peptide ^@ Lon proteolytic|||PDZ|||endopeptidase La ^@ http://purl.uniprot.org/annotation/PRO_5010292085 http://togogenome.org/gene/83332:Rv0121c ^@ http://purl.uniprot.org/uniprot/O07171 ^@ Region ^@ Domain Extent ^@ Putative_PNPOx ^@ http://togogenome.org/gene/83332:Rv2163c ^@ http://purl.uniprot.org/uniprot/L0T911 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Helix|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Acyl-ester intermediate|||Cytoplasmic|||Decreased interaction with Wag31. Loss of interaction, reduced protection from Rip1 proteolysis; when associated with 427-H--V-429 deletion.|||Decreased interaction with Wag31. Loss of interaction, reduced protection from Rip1 proteolysis; when associated with 488-Q--S-490 deletion.|||Extracellular|||Helical|||No degradation by Rip1.|||No effect on degradation by Rip1.|||Penicillin-binding protein PbpB|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000422679 http://togogenome.org/gene/83332:Rv2401A ^@ http://purl.uniprot.org/uniprot/Q79FE4 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2982c ^@ http://purl.uniprot.org/uniprot/P9WN77 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Glycerol-3-phosphate dehydrogenase [NAD(P)+]|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000137996 http://togogenome.org/gene/83332:Rv3865 ^@ http://purl.uniprot.org/uniprot/P9WJD1 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ ESX-1 secretion-associated protein EspF|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000393951 http://togogenome.org/gene/83332:Rv3833 ^@ http://purl.uniprot.org/uniprot/P96245 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH araC/xylS-type ^@ http://togogenome.org/gene/83332:Rv1070c ^@ http://purl.uniprot.org/uniprot/P9WNN9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Probable enoyl-CoA hydratase EchA8 ^@ http://purl.uniprot.org/annotation/PRO_0000109338 http://togogenome.org/gene/83332:Rv2818c ^@ http://purl.uniprot.org/uniprot/P71635 ^@ Molecule Processing ^@ Chain ^@ CRISPR system endoribonuclease Csm6 ^@ http://purl.uniprot.org/annotation/PRO_0000418229 http://togogenome.org/gene/83332:Rv0528 ^@ http://purl.uniprot.org/uniprot/O06394 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||ResB ^@ http://togogenome.org/gene/83332:Rv3665c ^@ http://purl.uniprot.org/uniprot/I6YGV9 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv0890c ^@ http://purl.uniprot.org/uniprot/P9WMG1 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH luxR-type|||Putative HTH-type transcriptional regulator Rv0890c ^@ http://purl.uniprot.org/annotation/PRO_0000184201 http://togogenome.org/gene/83332:Rv2276 ^@ http://purl.uniprot.org/uniprot/P9WPP7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mass|||Mutagenesis Site|||Strand|||Turn ^@ Considerable effects on the heme macrocycle conformation. Mutant leads to a more planar heme conformation.|||Has little effect on the heme conformation but significantly alters the environment of the heme and the affinity for azoles.|||Has little effect.|||Mycocyclosin synthase|||No significant change.|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052274 http://togogenome.org/gene/83332:Rv0353 ^@ http://purl.uniprot.org/uniprot/O06302 ^@ Region ^@ Coiled-Coil|||Domain Extent ^@ HTH merR-type ^@ http://togogenome.org/gene/83332:Rv1197 ^@ http://purl.uniprot.org/uniprot/P9WNJ7 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxK ^@ http://purl.uniprot.org/annotation/PRO_0000167803 http://togogenome.org/gene/83332:Rv2801A ^@ http://purl.uniprot.org/uniprot/P0CL61 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Antitoxin MazE9 ^@ http://purl.uniprot.org/annotation/PRO_0000406303 http://togogenome.org/gene/83332:Rv3217c ^@ http://purl.uniprot.org/uniprot/O05849 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1011 ^@ http://purl.uniprot.org/uniprot/P9WKG7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Propeptide|||Strand ^@ 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase|||4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, propeptide removed|||Removed|||Removed; alternate ^@ http://purl.uniprot.org/annotation/PRO_0000189235|||http://purl.uniprot.org/annotation/PRO_0000455339|||http://purl.uniprot.org/annotation/PRO_0000455340 http://togogenome.org/gene/83332:Rv1863c ^@ http://purl.uniprot.org/uniprot/P95152 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2683 ^@ http://purl.uniprot.org/uniprot/I6X540 ^@ Region ^@ Domain Extent ^@ CBS ^@ http://togogenome.org/gene/83332:Rv3036c ^@ http://purl.uniprot.org/uniprot/I6YF08 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Esterase Rv3036c|||Helical ^@ http://purl.uniprot.org/annotation/PRO_5010212191 http://togogenome.org/gene/83332:Rv1676 ^@ http://purl.uniprot.org/uniprot/O53923 ^@ Region ^@ Domain Extent ^@ AhpC-TSA ^@ http://togogenome.org/gene/83332:Rv1164 ^@ http://purl.uniprot.org/uniprot/O06562 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Nitrate_red_gam ^@ http://togogenome.org/gene/83332:Rv2859c ^@ http://purl.uniprot.org/uniprot/O33341 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Crosslink|||Domain Extent ^@ Glutamine amidotransferase type-1|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Nucleophile|||Putative glutamine amidotransferase Rv2859c ^@ http://purl.uniprot.org/annotation/PRO_0000396115 http://togogenome.org/gene/83332:Rv2511 ^@ http://purl.uniprot.org/uniprot/P9WIU1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Exonuclease|||Oligoribonuclease ^@ http://purl.uniprot.org/annotation/PRO_0000111051 http://togogenome.org/gene/83332:Rv3659c ^@ http://purl.uniprot.org/uniprot/P9WMT3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative conjugal transfer protein Rv3659c ^@ http://purl.uniprot.org/annotation/PRO_0000390679 http://togogenome.org/gene/83332:Rv3340 ^@ http://purl.uniprot.org/uniprot/O53390 ^@ Modification ^@ Modified Residue ^@ N6-(pyridoxal phosphate)lysine ^@ http://togogenome.org/gene/83332:Rv0584 ^@ http://purl.uniprot.org/uniprot/O86365 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized glycosidase Rv0584 ^@ http://purl.uniprot.org/annotation/PRO_0000415515 http://togogenome.org/gene/83332:Rv1977 ^@ http://purl.uniprot.org/uniprot/O53978 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Peptidase_M48 ^@ http://togogenome.org/gene/83332:Rv2364c ^@ http://purl.uniprot.org/uniprot/P9WNK9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue|||Mutagenesis Site ^@ Era-type G|||GTPase Era|||KH type-2|||N-acetylthreonine|||No GTPase activity.|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000180031 http://togogenome.org/gene/83332:Rv0045c ^@ http://purl.uniprot.org/uniprot/I6XU97 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 55-fold decrease in catalytic activity.|||550-fold decrease in catalytic activity.|||9000-fold decrease in catalytic activity.|||Esterase Rv0045c|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000451571 http://togogenome.org/gene/83332:Rv3161c ^@ http://purl.uniprot.org/uniprot/O53311 ^@ Region ^@ Domain Extent ^@ Rieske ^@ http://togogenome.org/gene/83332:Rv2972c ^@ http://purl.uniprot.org/uniprot/I6X5W6 ^@ Region ^@ Domain Extent ^@ DUF1524 ^@ http://togogenome.org/gene/83332:Rv2080 ^@ http://purl.uniprot.org/uniprot/P9WK77 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppJ|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018108 http://togogenome.org/gene/83332:Rv0189c ^@ http://purl.uniprot.org/uniprot/P9WKJ5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Dihydroxy-acid dehydratase|||Loss of catalytic activity.|||N-acetylproline|||N6-carboxylysine|||Proton acceptor|||Removed|||via carbamate group ^@ http://purl.uniprot.org/annotation/PRO_0000103481 http://togogenome.org/gene/83332:Rv0532 ^@ http://purl.uniprot.org/uniprot/L0T3X8 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv0701 ^@ http://purl.uniprot.org/uniprot/P9WH87 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L3 ^@ http://purl.uniprot.org/annotation/PRO_0000077125 http://togogenome.org/gene/83332:Rv0015c ^@ http://purl.uniprot.org/uniprot/P9WI83 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ 10-fold reduction in transphosphorylation activity. This mutant strain shows severely compromised growth. Loss of autophosphorylation activity and weak transphosphorylation activity; when associated with A-174.|||4-fold reduction in transphosphorylation activity.|||5-fold reduction in transphosphorylation activity. Loss of autophosphorylation activity and weak transphosphorylation activity; when associated with A-172.|||Cytoplasmic|||Extracellular|||Helical|||Loss of auto- and transphosphorylation activity.|||Loss of autophosphorylation activity. This mutation results in cell death.|||Loss of transphosphorylation activity.|||Phosphoserine; by autocatalysis|||Phosphothreonine; by autocatalysis|||Polar residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknA ^@ http://purl.uniprot.org/annotation/PRO_0000171205 http://togogenome.org/gene/83332:Rv0533c ^@ http://purl.uniprot.org/uniprot/P9WNG3 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes phosphorylation. Does not affect activity.|||Loss of activity.|||Mimics constitutive phosphorylation. Exhibits markedly decreased transacylation, malonyl-AcpM decarboxylation and condensing activities.|||Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III|||N-acetylthreonine|||Phosphothreonine|||Removed|||Retains 21% of wild-type activity. Loss of activity; when associated with A-161.|||Retains 69% of wild-type activity. Loss of activity; when associated with A-42 or A-46.|||Retains 7% of wild-type activity. Loss of activity; when associated with A-161. ^@ http://purl.uniprot.org/annotation/PRO_0000110443 http://togogenome.org/gene/83332:Rv1704c ^@ http://purl.uniprot.org/uniprot/O33203 ^@ Region ^@ Domain Extent|||Transmembrane ^@ AA_permease|||Helical ^@ http://togogenome.org/gene/83332:Rv0851c ^@ http://purl.uniprot.org/uniprot/O53863 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv0494 ^@ http://purl.uniprot.org/uniprot/P9WMG7 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH gntR-type|||Uncharacterized HTH-type transcriptional regulator Rv0494 ^@ http://purl.uniprot.org/annotation/PRO_0000050697 http://togogenome.org/gene/83332:Rv2203 ^@ http://purl.uniprot.org/uniprot/P9WLI7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||Uncharacterized protein Rv2203 ^@ http://purl.uniprot.org/annotation/PRO_0000103972 http://togogenome.org/gene/83332:Rv1672c ^@ http://purl.uniprot.org/uniprot/O53919 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MFS ^@ http://togogenome.org/gene/83332:Rv0671 ^@ http://purl.uniprot.org/uniprot/I6XVY0 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5030172889 http://togogenome.org/gene/83332:Rv2387 ^@ http://purl.uniprot.org/uniprot/P71757 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2030c ^@ http://purl.uniprot.org/uniprot/P9WLM1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2030c ^@ http://purl.uniprot.org/annotation/PRO_0000392909 http://togogenome.org/gene/83332:Rv1177 ^@ http://purl.uniprot.org/uniprot/O50433 ^@ Region ^@ Domain Extent ^@ 4Fe-4S ferredoxin-type ^@ http://togogenome.org/gene/83332:Rv1502 ^@ http://purl.uniprot.org/uniprot/P9WLW7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1502 ^@ http://purl.uniprot.org/annotation/PRO_0000103861 http://togogenome.org/gene/83332:Rv2345 ^@ http://purl.uniprot.org/uniprot/P9WFJ5 ^@ Molecule Processing|||Region ^@ Chain|||Coiled-Coil|||Signal Peptide|||Transmembrane ^@ Helical|||UPF0603 protein Rv2345 ^@ http://purl.uniprot.org/annotation/PRO_0000390675 http://togogenome.org/gene/83332:Rv0133 ^@ http://purl.uniprot.org/uniprot/P96810 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv3907c ^@ http://purl.uniprot.org/uniprot/L7N672 ^@ Region ^@ Domain Extent ^@ HDc ^@ http://togogenome.org/gene/83332:Rv2175c ^@ http://purl.uniprot.org/uniprot/O53509 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand ^@ Abolishes DNA-binding activity.|||DNA-binding protein Rv2175c|||Lack of phosphorylation. Retains DNA-binding activity.|||Phosphothreonine ^@ http://purl.uniprot.org/annotation/PRO_0000420875 http://togogenome.org/gene/83332:Rv0932c ^@ http://purl.uniprot.org/uniprot/P9WGT9 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Phosphate-binding protein PstS 2|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000031855 http://togogenome.org/gene/83332:Rv2688c ^@ http://purl.uniprot.org/uniprot/P9WQL7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Fluoroquinolones export ATP-binding protein Rv2688c ^@ http://purl.uniprot.org/annotation/PRO_0000390878 http://togogenome.org/gene/83332:Rv2993c ^@ http://purl.uniprot.org/uniprot/I6Y276 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Protein Rv2993c ^@ http://purl.uniprot.org/annotation/PRO_0000456000 http://togogenome.org/gene/83332:Rv3878 ^@ http://purl.uniprot.org/uniprot/P9WJC3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Modified Residue|||Mutagenesis Site ^@ ESX-1 secretion-associated protein EspJ|||Lack of phosphorylation. Increases the growth of mycobacteria.|||Phosphoserine|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000394148 http://togogenome.org/gene/83332:Rv1081c ^@ http://purl.uniprot.org/uniprot/O53429 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0900 ^@ http://purl.uniprot.org/uniprot/P9WJG7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein ArfB ^@ http://purl.uniprot.org/annotation/PRO_0000014083 http://togogenome.org/gene/83332:Rv2289 ^@ http://purl.uniprot.org/uniprot/P9WPG9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable CDP-diacylglycerol pyrophosphatase ^@ http://purl.uniprot.org/annotation/PRO_0000198580 http://togogenome.org/gene/83332:Rv3477 ^@ http://purl.uniprot.org/uniprot/I6YG87 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5030172890 http://togogenome.org/gene/83332:Rv0370c ^@ http://purl.uniprot.org/uniprot/O53705 ^@ Region ^@ Domain Extent ^@ AAA ^@ http://togogenome.org/gene/83332:Rv1717 ^@ http://purl.uniprot.org/uniprot/O86372 ^@ Molecule Processing ^@ Chain ^@ Beta-D-galactosidase Rv1717 ^@ http://purl.uniprot.org/annotation/PRO_0000456475 http://togogenome.org/gene/83332:Rv1208 ^@ http://purl.uniprot.org/uniprot/P9WMW9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Glucosyl-3-phosphoglycerate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000420163 http://togogenome.org/gene/83332:Rv2944 ^@ http://purl.uniprot.org/uniprot/P96287 ^@ Region ^@ Domain Extent ^@ AAA ^@ http://togogenome.org/gene/83332:Rv1376 ^@ http://purl.uniprot.org/uniprot/P71804 ^@ Region ^@ Domain Extent ^@ TfuA ^@ http://togogenome.org/gene/83332:Rv1021 ^@ http://purl.uniprot.org/uniprot/P96379 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Motif|||Mutagenesis Site ^@ Important for catalytic activity|||Nucleoside triphosphate pyrophosphohydrolase|||Pyrophosphohydrolase activity is reduced 20-fold. It affects the magnesium binding and the protein structure. ^@ http://purl.uniprot.org/annotation/PRO_0000401206 http://togogenome.org/gene/83332:Rv1686c ^@ http://purl.uniprot.org/uniprot/O33188 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC2_membrane|||Helical ^@ http://togogenome.org/gene/83332:Rv2527 ^@ http://purl.uniprot.org/uniprot/P9WF95 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC17 ^@ http://purl.uniprot.org/annotation/PRO_0000407876 http://togogenome.org/gene/83332:Rv3796 ^@ http://purl.uniprot.org/uniprot/P72062 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv3355c ^@ http://purl.uniprot.org/uniprot/O50384 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0596c ^@ http://purl.uniprot.org/uniprot/P9WF21 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ Antitoxin VapB4|||No effect. No longer neutralizes VapC4 in full-length VapB4; when associated with G-48; R-48 or E-54.|||No effect. No longer neutralizes VapC4 in full-length VapB4; when associated with low levels of G-48.|||No effect. No longer neutralizes VapC4 in full-length antitoxin, decreased interaction with VapC4 (tested for G-48 only); when associated with A-64.|||No effect. No longer neutralizes VapC4 in full-length antitoxin; when associated with A-64.|||No longer neutralizes VapC4 in full-length VapB4; when associated with low levels of G-48. ^@ http://purl.uniprot.org/annotation/PRO_0000408045 http://togogenome.org/gene/83332:Rv1989c ^@ http://purl.uniprot.org/uniprot/P9WLP9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand ^@ NAD(+) phosphorylase MbcT|||No change in toxicity.|||No longer toxic, does not degrade NAD(+).|||No longer toxic.|||Reduced toxicity. ^@ http://purl.uniprot.org/annotation/PRO_0000103918 http://togogenome.org/gene/83332:Rv2349c ^@ http://purl.uniprot.org/uniprot/P9WIB1 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Phospholipase C C|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000023944 http://togogenome.org/gene/83332:Rv3544c ^@ http://purl.uniprot.org/uniprot/P71857 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Acyl-CoA dehydrogenase FadE28|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000438517 http://togogenome.org/gene/83332:Rv0057 ^@ http://purl.uniprot.org/uniprot/P9WM77 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv0057 ^@ http://purl.uniprot.org/annotation/PRO_0000014066 http://togogenome.org/gene/83332:Rv3171c ^@ http://purl.uniprot.org/uniprot/O53321 ^@ Region ^@ Domain Extent ^@ Hydrolase_4 ^@ http://togogenome.org/gene/83332:Rv1822 ^@ http://purl.uniprot.org/uniprot/P9WPG5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative cardiolipin synthase ^@ http://purl.uniprot.org/annotation/PRO_0000056779 http://togogenome.org/gene/83332:Rv3359 ^@ http://purl.uniprot.org/uniprot/O50388 ^@ Region ^@ Domain Extent ^@ Oxidored_FMN ^@ http://togogenome.org/gene/83332:Rv3857c ^@ http://purl.uniprot.org/uniprot/P96220 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3316 ^@ http://purl.uniprot.org/uniprot/O53368 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Transmembrane ^@ Helical|||Removed|||Succinate dehydrogenase 2 membrane subunit SdhC|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000432512 http://togogenome.org/gene/83332:Rv0711 ^@ http://purl.uniprot.org/uniprot/P95059 ^@ Modification|||Region ^@ Domain Extent|||Modified Residue ^@ 3-oxoalanine (Cys)|||Sulfatase ^@ http://togogenome.org/gene/83332:Rv2750 ^@ http://purl.uniprot.org/uniprot/P9WGS5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv2750 ^@ http://purl.uniprot.org/annotation/PRO_0000416412 http://togogenome.org/gene/83332:Rv0544c ^@ http://purl.uniprot.org/uniprot/O06410 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1389 ^@ http://purl.uniprot.org/uniprot/P9WKE9 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Guanylate kinase|||Guanylate kinase-like|||N-acetylserine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000170570 http://togogenome.org/gene/83332:Rv0861c ^@ http://purl.uniprot.org/uniprot/O53873 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif|||Mutagenesis Site ^@ DEAH box|||DNA helicase XPB|||Helicase ATP-binding|||Helicase C-terminal|||Loss of ATPase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000455759 http://togogenome.org/gene/83332:Rv2213 ^@ http://purl.uniprot.org/uniprot/P9WHT3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Probable cytosol aminopeptidase ^@ http://purl.uniprot.org/annotation/PRO_0000165771 http://togogenome.org/gene/83332:Rv2911 ^@ http://purl.uniprot.org/uniprot/I6Y204 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Signal Peptide|||Strand|||Turn ^@ Acyl-ester intermediate|||D-alanyl-D-alanine carboxypeptidase DacB2|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_5010244966 http://togogenome.org/gene/83332:Rv1223 ^@ http://purl.uniprot.org/uniprot/O06291 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Charge relay system|||Cytoplasmic|||Helical|||PDZ|||Periplasmic|||Polar residues|||Probable serine protease HtrA1 ^@ http://purl.uniprot.org/annotation/PRO_0000450814 http://togogenome.org/gene/83332:Rv0682 ^@ http://purl.uniprot.org/uniprot/P9WH63 ^@ Molecule Processing|||Natural Variation ^@ Chain|||Sequence Variant ^@ 30S ribosomal protein S12|||In strain: 9106, 9181, An03, F12, F18 and TCVGH21; resistant to streptomycin.|||In strain: C37; probably resistant to streptomycin.|||In strain: F05; resistant to streptomycin.|||In strain: F18; resistant to streptomycin.|||In strain: TCVGH25; probably resistant to streptomycin. ^@ http://purl.uniprot.org/annotation/PRO_0000146272 http://togogenome.org/gene/83332:Rv2399c ^@ http://purl.uniprot.org/uniprot/P71745 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv2040c ^@ http://purl.uniprot.org/uniprot/O53484 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv1187 ^@ http://purl.uniprot.org/uniprot/O50443 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ Aldedh ^@ http://togogenome.org/gene/83332:Rv2870c ^@ http://purl.uniprot.org/uniprot/P9WNS1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ 1-deoxy-D-xylulose 5-phosphate reductoisomerase ^@ http://purl.uniprot.org/annotation/PRO_0000163678 http://togogenome.org/gene/83332:Rv2601A ^@ http://purl.uniprot.org/uniprot/P9WJ21 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB41 ^@ http://purl.uniprot.org/annotation/PRO_0000408082 http://togogenome.org/gene/83332:Rv2700 ^@ http://purl.uniprot.org/uniprot/I6Y1I5 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||LytR_C ^@ http://togogenome.org/gene/83332:Rv3005c ^@ http://purl.uniprot.org/uniprot/I6YAV3 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3554 ^@ http://purl.uniprot.org/uniprot/P71846 ^@ Region ^@ Domain Extent|||Transmembrane ^@ 2Fe-2S ferredoxin-type|||FAD-binding FR-type|||Helical ^@ http://togogenome.org/gene/83332:Rv3370c ^@ http://purl.uniprot.org/uniprot/P9WNT5 ^@ Molecule Processing ^@ Chain ^@ Error-prone DNA polymerase ^@ http://purl.uniprot.org/annotation/PRO_0000103385 http://togogenome.org/gene/83332:Rv2838c ^@ http://purl.uniprot.org/uniprot/P9WHJ7 ^@ Molecule Processing ^@ Chain ^@ Ribosome-binding factor A ^@ http://purl.uniprot.org/annotation/PRO_0000102698 http://togogenome.org/gene/83332:Rv1477 ^@ http://purl.uniprot.org/uniprot/O53168 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ Abolishes host cell invasion and survival in host macrophages.|||Abolishes host cell invasion.|||Loss of enzyme activity.|||NlpC/P60|||Nucleophile|||Peptidoglycan endopeptidase RipA|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000413762 http://togogenome.org/gene/83332:Rv0232 ^@ http://purl.uniprot.org/uniprot/P96415 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2299c ^@ http://purl.uniprot.org/uniprot/P9WMJ7 ^@ Molecule Processing ^@ Chain ^@ Chaperone protein HtpG ^@ http://purl.uniprot.org/annotation/PRO_0000062996 http://togogenome.org/gene/83332:Rv3533c ^@ http://purl.uniprot.org/uniprot/P9WHX7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide ^@ Polar residues|||Uncharacterized PPE family protein PPE62 ^@ http://purl.uniprot.org/annotation/PRO_0000379117 http://togogenome.org/gene/83332:Rv0199 ^@ http://purl.uniprot.org/uniprot/O53650 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2108 ^@ http://purl.uniprot.org/uniprot/P9WI01 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE36 ^@ http://purl.uniprot.org/annotation/PRO_0000379113 http://togogenome.org/gene/83332:Rv0025 ^@ http://purl.uniprot.org/uniprot/P9WMA1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0025 ^@ http://purl.uniprot.org/annotation/PRO_0000103642 http://togogenome.org/gene/83332:Rv1727 ^@ http://purl.uniprot.org/uniprot/P71985 ^@ Region ^@ Domain Extent ^@ MDMPI_N ^@ http://togogenome.org/gene/83332:Rv1219c ^@ http://purl.uniprot.org/uniprot/O86312 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Mutagenesis Site|||Strand ^@ H-T-H motif|||HTH tetR-type|||HTH-type transcriptional regulatory protein RaaS|||Reduces DNA binding affinity and ligand binding. ^@ http://purl.uniprot.org/annotation/PRO_0000447332 http://togogenome.org/gene/83332:Rv3495c ^@ http://purl.uniprot.org/uniprot/I6Y3P1 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ Lipoprotein LprN|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000438419 http://togogenome.org/gene/83332:Rv2954c ^@ http://purl.uniprot.org/uniprot/I6X5U4 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv0203 ^@ http://purl.uniprot.org/uniprot/I6X8R5 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Disulfide Bond|||Mutagenesis Site|||Signal Peptide ^@ Decrease in heme binding.|||Decrease in heme binding. Strong decrease in heme binding; when associated with A-64.|||Decrease in heme binding. Strong decrease in heme binding; when associated with A-90.|||Does not bind heme.|||Heme-binding protein Rv0203|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000432886 http://togogenome.org/gene/83332:Rv1031 ^@ http://purl.uniprot.org/uniprot/P9WKF1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Potassium-transporting ATPase KdpC subunit ^@ http://purl.uniprot.org/annotation/PRO_0000196999 http://togogenome.org/gene/83332:Rv0693 ^@ http://purl.uniprot.org/uniprot/P9WJ79 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Mycofactocin maturase MftC|||Radical SAM core ^@ http://purl.uniprot.org/annotation/PRO_0000415281 http://togogenome.org/gene/83332:Rv3648c ^@ http://purl.uniprot.org/uniprot/P9WP75 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ CSD|||Probable cold shock protein A ^@ http://purl.uniprot.org/annotation/PRO_0000100312 http://togogenome.org/gene/83332:Rv1696 ^@ http://purl.uniprot.org/uniprot/P9WHI7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ DNA repair protein RecN ^@ http://purl.uniprot.org/annotation/PRO_0000188022 http://togogenome.org/gene/83332:Rv2538c ^@ http://purl.uniprot.org/uniprot/P9WPX9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Sequence Conflict|||Strand|||Turn ^@ 3-dehydroquinate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000140757 http://togogenome.org/gene/83332:Rv1999c ^@ http://purl.uniprot.org/uniprot/P9WQM3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized transporter Rv1999c ^@ http://purl.uniprot.org/annotation/PRO_0000054227 http://togogenome.org/gene/83332:Rv0069c ^@ http://purl.uniprot.org/uniprot/C7FLQ4|||http://purl.uniprot.org/uniprot/P9WGT5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ L-serine dehydratase|||SDH_alpha|||SDH_beta ^@ http://purl.uniprot.org/annotation/PRO_0000171909 http://togogenome.org/gene/83332:Rv3182 ^@ http://purl.uniprot.org/uniprot/O53332 ^@ Molecule Processing ^@ Chain ^@ Putative toxin HigB3 ^@ http://purl.uniprot.org/annotation/PRO_0000432914 http://togogenome.org/gene/83332:Rv1832 ^@ http://purl.uniprot.org/uniprot/P9WN53 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Probable glycine dehydrogenase (decarboxylating) ^@ http://purl.uniprot.org/annotation/PRO_0000166920 http://togogenome.org/gene/83332:Rv2656c ^@ http://purl.uniprot.org/uniprot/P9WL49 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2656c ^@ http://purl.uniprot.org/annotation/PRO_0000104081 http://togogenome.org/gene/83332:Rv3867 ^@ http://purl.uniprot.org/uniprot/O69732 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||ESX-1 secretion-associated protein EspH ^@ http://purl.uniprot.org/annotation/PRO_0000394146 http://togogenome.org/gene/83332:Rv0754 ^@ http://purl.uniprot.org/uniprot/Q79FW5 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ Lack of phosphoglycerate mutase activity.|||PE|||PE-PGRS family protein PE_PGRS11|||Proton donor/acceptor|||Tele-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_5004287637 http://togogenome.org/gene/83332:Rv0722 ^@ http://purl.uniprot.org/uniprot/P9WHA3 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L30 ^@ http://purl.uniprot.org/annotation/PRO_0000104599 http://togogenome.org/gene/83332:Rv2486 ^@ http://purl.uniprot.org/uniprot/P9WNN5 ^@ Molecule Processing ^@ Chain ^@ Probable enoyl-CoA hydratase EchA14 ^@ http://purl.uniprot.org/annotation/PRO_0000109343 http://togogenome.org/gene/83332:Rv3680 ^@ http://purl.uniprot.org/uniprot/I6Y498 ^@ Region ^@ Domain Extent ^@ ArsA_ATPase ^@ http://togogenome.org/gene/83332:Rv0554 ^@ http://purl.uniprot.org/uniprot/P9WNH1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Putative non-heme bromoperoxidase BpoC ^@ http://purl.uniprot.org/annotation/PRO_0000414587 http://togogenome.org/gene/83332:Rv0871 ^@ http://purl.uniprot.org/uniprot/I6WZM9 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||CSD ^@ http://togogenome.org/gene/83332:Rv1402 ^@ http://purl.uniprot.org/uniprot/P9WMQ9 ^@ Molecule Processing|||Region ^@ Chain|||Zinc Finger ^@ C4-type|||Probable primosomal protein N' ^@ http://purl.uniprot.org/annotation/PRO_0000102129 http://togogenome.org/gene/83332:Rv3022A ^@ http://purl.uniprot.org/uniprot/Q6MX17 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010161334 http://togogenome.org/gene/83332:Rv1233c ^@ http://purl.uniprot.org/uniprot/O86316 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ DUF4190|||Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2055c ^@ http://purl.uniprot.org/uniprot/P9WH47 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S18 2 ^@ http://purl.uniprot.org/annotation/PRO_0000111191 http://togogenome.org/gene/83332:Rv2883c ^@ http://purl.uniprot.org/uniprot/P9WHK5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylthreonine|||Removed|||Uridylate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000143863 http://togogenome.org/gene/83332:Rv1519 ^@ http://purl.uniprot.org/uniprot/P9WLV7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1519 ^@ http://purl.uniprot.org/annotation/PRO_0000103866 http://togogenome.org/gene/83332:Rv1887 ^@ http://purl.uniprot.org/uniprot/O07745 ^@ Region ^@ Compositionally Biased Region ^@ Pro residues ^@ http://togogenome.org/gene/83332:Rv3052c ^@ http://purl.uniprot.org/uniprot/P9WIZ3 ^@ Molecule Processing ^@ Chain ^@ Protein NrdI ^@ http://purl.uniprot.org/annotation/PRO_0000164327 http://togogenome.org/gene/83332:Rv1854c ^@ http://purl.uniprot.org/uniprot/P95160 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ Helical|||Type II NADH:quinone oxidoreductase Ndh ^@ http://purl.uniprot.org/annotation/PRO_0000452727 http://togogenome.org/gene/83332:Rv2710 ^@ http://purl.uniprot.org/uniprot/P9WGI5 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Motif ^@ H-T-H motif|||Polymerase core binding|||RNA polymerase sigma factor SigB ^@ http://purl.uniprot.org/annotation/PRO_0000423644 http://togogenome.org/gene/83332:Rv3565 ^@ http://purl.uniprot.org/uniprot/P96847 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||Valine--pyruvate aminotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000450668 http://togogenome.org/gene/83332:Rv0815c ^@ http://purl.uniprot.org/uniprot/P9WHF9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Cysteine persulfide intermediate|||Putative thiosulfate sulfurtransferase|||Rhodanese 1|||Rhodanese 2 ^@ http://purl.uniprot.org/annotation/PRO_0000139415 http://togogenome.org/gene/83332:Rv3015c ^@ http://purl.uniprot.org/uniprot/I6YAW3 ^@ Region ^@ Domain Extent ^@ Meth_synt_2 ^@ http://togogenome.org/gene/83332:Rv1343c ^@ http://purl.uniprot.org/uniprot/P9WK51 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Lipid Binding|||Signal Peptide|||Transmembrane ^@ Helical|||N-palmitoyl cysteine|||Putative lipoprotein LprD|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000103817 http://togogenome.org/gene/83332:Rv3384c ^@ http://purl.uniprot.org/uniprot/O50411 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC46 ^@ http://purl.uniprot.org/annotation/PRO_0000407898 http://togogenome.org/gene/83332:Rv2848c ^@ http://purl.uniprot.org/uniprot/P9WP97 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ GATase cobBQ-type|||Hydrogenobyrinate a,c-diamide synthase|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000141262 http://togogenome.org/gene/83332:Rv1488 ^@ http://purl.uniprot.org/uniprot/P9WPR9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1488 ^@ http://purl.uniprot.org/annotation/PRO_0000094060 http://togogenome.org/gene/83332:Rv0243 ^@ http://purl.uniprot.org/uniprot/O86361 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Acyl-thioester intermediate|||Proton acceptor|||Thiolase_C|||Thiolase_N ^@ http://togogenome.org/gene/83332:Rv3596c ^@ http://purl.uniprot.org/uniprot/P9WPC9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ ATP-dependent Clp protease ATP-binding subunit ClpC1|||Clp R|||UVR ^@ http://purl.uniprot.org/annotation/PRO_0000191236 http://togogenome.org/gene/83332:Rv3691 ^@ http://purl.uniprot.org/uniprot/O69659 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein Rv3691 ^@ http://purl.uniprot.org/annotation/PRO_0000415511 http://togogenome.org/gene/83332:Rv0394c ^@ http://purl.uniprot.org/uniprot/P95202 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0917 ^@ http://purl.uniprot.org/uniprot/P9WPR7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized transporter Rv0917 ^@ http://purl.uniprot.org/annotation/PRO_0000201497 http://togogenome.org/gene/83332:Rv1737c ^@ http://purl.uniprot.org/uniprot/P9WJY7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable nitrate/nitrite transporter NarK2 ^@ http://purl.uniprot.org/annotation/PRO_0000392910 http://togogenome.org/gene/83332:Rv0883c ^@ http://purl.uniprot.org/uniprot/P9WKQ7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0883c ^@ http://purl.uniprot.org/annotation/PRO_0000103725 http://togogenome.org/gene/83332:Rv3506 ^@ http://purl.uniprot.org/uniprot/O53551 ^@ Molecule Processing ^@ Chain ^@ Medium/long-chain-fatty-acid--CoA ligase FadD17 ^@ http://purl.uniprot.org/annotation/PRO_0000406787 http://togogenome.org/gene/83332:Rv2964 ^@ http://purl.uniprot.org/uniprot/P9WHM3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ ACT|||Formyltetrahydrofolate deformylase|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000074964 http://togogenome.org/gene/83332:Rv0213c ^@ http://purl.uniprot.org/uniprot/P96395 ^@ Region ^@ Domain Extent ^@ B12-binding|||Radical SAM core ^@ http://togogenome.org/gene/83332:Rv0703 ^@ http://purl.uniprot.org/uniprot/P9WHB9 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L23 ^@ http://purl.uniprot.org/annotation/PRO_0000129421 http://togogenome.org/gene/83332:Rv1895 ^@ http://purl.uniprot.org/uniprot/O07737 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable zinc-binding alcohol dehydrogenase Rv1895 ^@ http://purl.uniprot.org/annotation/PRO_0000415504 http://togogenome.org/gene/83332:Rv0159c ^@ http://purl.uniprot.org/uniprot/Q79G04 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE family protein PE3|||PE-PPE ^@ http://purl.uniprot.org/annotation/PRO_0000438129 http://togogenome.org/gene/83332:Rv3662c ^@ http://purl.uniprot.org/uniprot/I6YCP7 ^@ Region ^@ Domain Extent ^@ Fido ^@ http://togogenome.org/gene/83332:Rv2410c ^@ http://purl.uniprot.org/uniprot/P71733 ^@ Region ^@ Domain Extent ^@ Alpha-E ^@ http://togogenome.org/gene/83332:Rv0510 ^@ http://purl.uniprot.org/uniprot/P9WMP3 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ Porphobilinogen deaminase|||S-(dipyrrolylmethanemethyl)cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000142960 http://togogenome.org/gene/83332:Rv3062 ^@ http://purl.uniprot.org/uniprot/P9WNV5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ DNA ligase B|||N6-AMP-lysine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000365231 http://togogenome.org/gene/83332:Rv0338c ^@ http://purl.uniprot.org/uniprot/O33268 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ 4Fe-4S ferredoxin-type|||Basic and acidic residues|||Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2548 ^@ http://purl.uniprot.org/uniprot/P9WF93 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC19 ^@ http://purl.uniprot.org/annotation/PRO_0000407878 http://togogenome.org/gene/83332:Rv0826 ^@ http://purl.uniprot.org/uniprot/O53837 ^@ Region ^@ Domain Extent ^@ MPAB_Lcp_cat ^@ http://togogenome.org/gene/83332:Rv3911 ^@ http://purl.uniprot.org/uniprot/O53590 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Motif ^@ ECF RNA polymerase sigma factor SigM|||H-T-H motif|||Polymerase core binding ^@ http://purl.uniprot.org/annotation/PRO_0000420400 http://togogenome.org/gene/83332:Rv2010 ^@ http://purl.uniprot.org/uniprot/P9WF97 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ PINc|||Ribonuclease VapC15 ^@ http://purl.uniprot.org/annotation/PRO_0000103939 http://togogenome.org/gene/83332:Rv2377c ^@ http://purl.uniprot.org/uniprot/P9WIP5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Protein MbtH ^@ http://purl.uniprot.org/annotation/PRO_0000096276 http://togogenome.org/gene/83332:Rv1843c ^@ http://purl.uniprot.org/uniprot/P9WKI3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ CBS 1|||CBS 2|||GMP reductase|||Thioimidate intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000093785 http://togogenome.org/gene/83332:Rv2668 ^@ http://purl.uniprot.org/uniprot/P71965 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010255821 http://togogenome.org/gene/83332:Rv0841 ^@ http://purl.uniprot.org/uniprot/I6WZK3 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0732 ^@ http://purl.uniprot.org/uniprot/P9WGN3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Protein translocase subunit SecY ^@ http://purl.uniprot.org/annotation/PRO_0000131732 http://togogenome.org/gene/83332:Rv2498c ^@ http://purl.uniprot.org/uniprot/P9WPE1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Citrate lyase subunit beta-like protein ^@ http://purl.uniprot.org/annotation/PRO_0000286388 http://togogenome.org/gene/83332:Rv3335c ^@ http://purl.uniprot.org/uniprot/O53385 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2974c ^@ http://purl.uniprot.org/uniprot/I6Y259 ^@ Region ^@ Domain Extent ^@ DhaL ^@ http://togogenome.org/gene/83332:Rv0224c ^@ http://purl.uniprot.org/uniprot/P9WJZ9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized methyltransferase Rv0224c ^@ http://purl.uniprot.org/annotation/PRO_0000380608 http://togogenome.org/gene/83332:Rv1412 ^@ http://purl.uniprot.org/uniprot/P9WK35 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Repeat ^@ Lumazine-binding 1|||Lumazine-binding 2|||Riboflavin synthase|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000068168 http://togogenome.org/gene/83332:Rv3157 ^@ http://purl.uniprot.org/uniprot/P9WIW5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||NADH-quinone oxidoreductase subunit M ^@ http://purl.uniprot.org/annotation/PRO_0000118044 http://togogenome.org/gene/83332:Rv1244 ^@ http://purl.uniprot.org/uniprot/O50459 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ OpuAC ^@ http://purl.uniprot.org/annotation/PRO_5010295864 http://togogenome.org/gene/83332:Rv2067c ^@ http://purl.uniprot.org/uniprot/P9WLL9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2067c ^@ http://purl.uniprot.org/annotation/PRO_0000103943 http://togogenome.org/gene/83332:Rv1708 ^@ http://purl.uniprot.org/uniprot/P9WLT1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Uncharacterized protein Rv1708 ^@ http://purl.uniprot.org/annotation/PRO_0000390677 http://togogenome.org/gene/83332:Rv2894c ^@ http://purl.uniprot.org/uniprot/P9WF35 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Core-binding (CB)|||O-(3'-phospho-DNA)-tyrosine intermediate|||Tyr recombinase|||Tyrosine recombinase XerC ^@ http://purl.uniprot.org/annotation/PRO_0000095306 http://togogenome.org/gene/83332:Rv1529 ^@ http://purl.uniprot.org/uniprot/O53903 ^@ Region ^@ Domain Extent ^@ AMP-binding ^@ http://togogenome.org/gene/83332:Rv1899c ^@ http://purl.uniprot.org/uniprot/P9WK29 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Macro|||Uncharacterized protein Rv1899c ^@ http://purl.uniprot.org/annotation/PRO_0000089202 http://togogenome.org/gene/83332:Rv1865c ^@ http://purl.uniprot.org/uniprot/P95150 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2720 ^@ http://purl.uniprot.org/uniprot/P9WHR7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||DNA Binding|||Helix|||Strand ^@ For autocatalytic cleavage activity|||H-T-H motif|||LexA repressor ^@ http://purl.uniprot.org/annotation/PRO_0000170059 http://togogenome.org/gene/83332:Rv1353c ^@ http://purl.uniprot.org/uniprot/P9WMD3 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||HTH-type transcriptional repressor Rv1353c ^@ http://purl.uniprot.org/annotation/PRO_0000070662 http://togogenome.org/gene/83332:Rv2190c ^@ http://purl.uniprot.org/uniprot/P9WHU3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ NlpC/P60|||Nucleophile|||Pro residues|||Probable endopeptidase Rv2190c|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000109873 http://togogenome.org/gene/83332:Rv3395c ^@ http://purl.uniprot.org/uniprot/P9WKZ9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv3395c ^@ http://purl.uniprot.org/annotation/PRO_0000104116 http://togogenome.org/gene/83332:Rv1202 ^@ http://purl.uniprot.org/uniprot/P9WHS9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Putative succinyl-diaminopimelate desuccinylase DapE ^@ http://purl.uniprot.org/annotation/PRO_0000414592 http://togogenome.org/gene/83332:Rv0253 ^@ http://purl.uniprot.org/uniprot/O53675 ^@ Region ^@ Domain Extent ^@ Rieske_2 ^@ http://togogenome.org/gene/83332:Rv0935 ^@ http://purl.uniprot.org/uniprot/P9WG07 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Sequence Conflict|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Phosphate transport system permease protein PstC 1 ^@ http://purl.uniprot.org/annotation/PRO_0000060218 http://togogenome.org/gene/83332:Rv3682 ^@ http://purl.uniprot.org/uniprot/I6YGX2 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PASTA|||Pro residues|||peptidoglycan glycosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_5010223156 http://togogenome.org/gene/83332:Rv3191c ^@ http://purl.uniprot.org/uniprot/O53337 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic residues|||Integrase catalytic ^@ http://togogenome.org/gene/83332:Rv3701c ^@ http://purl.uniprot.org/uniprot/P9WN47 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Histidine N-alpha-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000413652 http://togogenome.org/gene/83332:Rv0404 ^@ http://purl.uniprot.org/uniprot/P9WQ57 ^@ Molecule Processing ^@ Chain ^@ Probable long-chain-fatty-acid--AMP ligase FadD30 ^@ http://purl.uniprot.org/annotation/PRO_0000406631 http://togogenome.org/gene/83332:Rv0929 ^@ http://purl.uniprot.org/uniprot/P9WG05 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Sequence Conflict|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Phosphate transport system permease protein PstC 2 ^@ http://purl.uniprot.org/annotation/PRO_0000060219 http://togogenome.org/gene/83332:Rv0575c ^@ http://purl.uniprot.org/uniprot/O53772 ^@ Region ^@ Domain Extent ^@ FAD_binding_3 ^@ http://togogenome.org/gene/83332:Rv2158c ^@ http://purl.uniprot.org/uniprot/P9WJL3 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Motif|||Strand|||Turn ^@ Meso-diaminopimelate recognition motif|||N6-carboxylysine|||UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase ^@ http://purl.uniprot.org/annotation/PRO_0000101913 http://togogenome.org/gene/83332:Rv3672c ^@ http://purl.uniprot.org/uniprot/I6XHX8 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Nudix hydrolase|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1588c ^@ http://purl.uniprot.org/uniprot/P9WLT9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic residues|||Uncharacterized protein Rv1588c ^@ http://purl.uniprot.org/annotation/PRO_0000103886 http://togogenome.org/gene/83332:Rv1551 ^@ http://purl.uniprot.org/uniprot/P9WI59 ^@ Molecule Processing|||Region ^@ Chain|||Motif ^@ HXXXXD motif|||Putative acyltransferase plsB1 ^@ http://purl.uniprot.org/annotation/PRO_0000195244 http://togogenome.org/gene/83332:Rv0524 ^@ http://purl.uniprot.org/uniprot/P9WMN9 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Modified Residue ^@ Glutamate-1-semialdehyde 2,1-aminomutase|||N6-(pyridoxal phosphate)lysine|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000120425 http://togogenome.org/gene/83332:Rv1378c ^@ http://purl.uniprot.org/uniprot/P71806 ^@ Region ^@ Domain Extent ^@ HNHc ^@ http://togogenome.org/gene/83332:Rv3073c ^@ http://purl.uniprot.org/uniprot/P9WL11 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3073c ^@ http://purl.uniprot.org/annotation/PRO_0000104112 http://togogenome.org/gene/83332:Rv0011c ^@ http://purl.uniprot.org/uniprot/P9WP57 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Topological Domain|||Transmembrane ^@ Cell division protein CrgA|||Cytoplasmic|||Extracellular|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000216814 http://togogenome.org/gene/83332:Rv0876c ^@ http://purl.uniprot.org/uniprot/P9WKR5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0876c ^@ http://purl.uniprot.org/annotation/PRO_0000103719 http://togogenome.org/gene/83332:Rv2558 ^@ http://purl.uniprot.org/uniprot/P9WLA3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2558 ^@ http://purl.uniprot.org/annotation/PRO_0000104037 http://togogenome.org/gene/83332:Rv1205 ^@ http://purl.uniprot.org/uniprot/O05306 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink|||Mutagenesis Site ^@ Abrogates pupylation. This mutant accumulates in M.tuberculosis with a functional proteasome system and sensitizes M.tuberculosis to NO. Decrease in catalytic activity.|||Cytokinin riboside 5'-monophosphate phosphoribohydrolase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Large decrease in catalytic activity.|||Loss of catalytic activity. ^@ http://purl.uniprot.org/annotation/PRO_0000433000 http://togogenome.org/gene/83332:Rv0840c ^@ http://purl.uniprot.org/uniprot/I6Y8X0 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ AB hydrolase-1|||Nucleophile|||Proton donor ^@ http://togogenome.org/gene/83332:Rv2389c ^@ http://purl.uniprot.org/uniprot/I6Y0L9|||http://purl.uniprot.org/uniprot/P9WG27 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Non-terminal Residue|||Transmembrane ^@ Helical|||Resuscitation-promoting factor RpfD|||Transglycosylas ^@ http://purl.uniprot.org/annotation/PRO_0000421030 http://togogenome.org/gene/83332:Rv1169c ^@ http://purl.uniprot.org/uniprot/Q79FR5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Esterase PE11|||PE ^@ http://purl.uniprot.org/annotation/PRO_0000451088 http://togogenome.org/gene/83332:Rv1018c ^@ http://purl.uniprot.org/uniprot/P9WMN3 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Crosslink|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Bifunctional protein GlmU|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylthreonine|||Polar residues|||Proton acceptor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000233802 http://togogenome.org/gene/83332:Rv2768c ^@ http://purl.uniprot.org/uniprot/Q79FA9 ^@ Region ^@ Domain Extent ^@ PPE|||PPE-SVP ^@ http://togogenome.org/gene/83332:Rv3201c ^@ http://purl.uniprot.org/uniprot/O53347 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ UvrD-like helicase ATP-binding|||UvrD-like helicase C-terminal ^@ http://togogenome.org/gene/83332:Rv0414c ^@ http://purl.uniprot.org/uniprot/P9WG75 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Thiamine-phosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000157026 http://togogenome.org/gene/83332:Rv3546 ^@ http://purl.uniprot.org/uniprot/I6XHI4 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Acyl-thioester intermediate|||Proton acceptor|||Steroid 3-ketoacyl-CoA thiolase ^@ http://purl.uniprot.org/annotation/PRO_0000438502 http://togogenome.org/gene/83332:Rv2508c ^@ http://purl.uniprot.org/uniprot/O06171 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3352c ^@ http://purl.uniprot.org/uniprot/O50381 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv2984 ^@ http://purl.uniprot.org/uniprot/A5YKM2|||http://purl.uniprot.org/uniprot/P9WHV9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||PP_kinase|||PP_kinase_C|||PP_kinase_C_1|||PP_kinase_N|||Phosphohistidine intermediate|||Polyphosphate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000128648 http://togogenome.org/gene/83332:Rv0234c ^@ http://purl.uniprot.org/uniprot/P9WNX9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Nucleophile|||Proton acceptor|||Succinate-semialdehyde dehydrogenase [NADP(+)] 1 ^@ http://purl.uniprot.org/annotation/PRO_0000310705 http://togogenome.org/gene/83332:Rv1422 ^@ http://purl.uniprot.org/uniprot/P9WMU5 ^@ Experimental Information|||Modification|||Molecule Processing ^@ Chain|||Modified Residue|||Mutagenesis Site ^@ Lack of phosphorylation.|||Phosphothreonine|||Putative gluconeogenesis factor ^@ http://purl.uniprot.org/annotation/PRO_0000107811 http://togogenome.org/gene/83332:Rv3168 ^@ http://purl.uniprot.org/uniprot/P9WI99 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||Putative aminoglycoside phosphotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000420881 http://togogenome.org/gene/83332:Rv0042c ^@ http://purl.uniprot.org/uniprot/P71699 ^@ Region ^@ Domain Extent ^@ HTH marR-type ^@ http://togogenome.org/gene/83332:Rv0537c ^@ http://purl.uniprot.org/uniprot/O06403 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2077c ^@ http://purl.uniprot.org/uniprot/P9WLL1 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2077c ^@ http://purl.uniprot.org/annotation/PRO_0000014120 http://togogenome.org/gene/83332:Rv0362 ^@ http://purl.uniprot.org/uniprot/O06312 ^@ Region ^@ Domain Extent|||Transmembrane ^@ CBS|||Helical ^@ http://togogenome.org/gene/83332:Rv1539 ^@ http://purl.uniprot.org/uniprot/P9WK99 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Transmembrane ^@ Helical|||Lipoprotein signal peptidase ^@ http://purl.uniprot.org/annotation/PRO_0000178798 http://togogenome.org/gene/83332:Rv3289c ^@ http://purl.uniprot.org/uniprot/P96894 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1909c ^@ http://purl.uniprot.org/uniprot/P9WN87 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Transcriptional regulator FurA ^@ http://purl.uniprot.org/annotation/PRO_0000095562 http://togogenome.org/gene/83332:Rv2401 ^@ http://purl.uniprot.org/uniprot/O86326 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv1365c ^@ http://purl.uniprot.org/uniprot/P9WGE3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Disulfide Bond|||Domain Extent|||Mutagenesis Site ^@ Anti-sigma-F factor antagonist RsfA|||Constitutive interaction with RsbW; leads to active SigF.|||STAS ^@ http://purl.uniprot.org/annotation/PRO_0000194209 http://togogenome.org/gene/83332:Rv2862A ^@ http://purl.uniprot.org/uniprot/P0CW32 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB23 ^@ http://purl.uniprot.org/annotation/PRO_0000408068 http://togogenome.org/gene/83332:Rv2200c ^@ http://purl.uniprot.org/uniprot/P9WP69 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Signal Peptide|||Transmembrane ^@ Cytochrome c oxidase subunit 2|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000006058 http://togogenome.org/gene/83332:Rv3406 ^@ http://purl.uniprot.org/uniprot/P9WKZ1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Alpha-ketoglutarate-dependent sulfate ester dioxygenase ^@ http://purl.uniprot.org/annotation/PRO_0000104125 http://togogenome.org/gene/83332:Rv0267 ^@ http://purl.uniprot.org/uniprot/P95224 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2027c ^@ http://purl.uniprot.org/uniprot/P9WGK1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ GAF 1|||GAF 2|||Heme iron oxidizes more easily.|||Histidine kinase|||No autophosphorylation, no phosphate transfer to DevR (DosR).|||No autophosphorylation.|||Oxygen sensor histidine kinase response regulator DosT|||Phosphohistidine; by autocatalysis|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000392624 http://togogenome.org/gene/83332:Rv2867c ^@ http://purl.uniprot.org/uniprot/I6XFI7 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv2518c ^@ http://purl.uniprot.org/uniprot/I6Y9J2 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Lipid Binding|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ Decreases stability of the covalent enzyme-meropenem adduct.|||L,D-transpeptidase 2|||N-palmitoyl cysteine|||Nucleophile|||Proton donor/acceptor|||S-diacylglycerol cysteine|||YkuD ^@ http://purl.uniprot.org/annotation/PRO_0000430334 http://togogenome.org/gene/83332:Rv3711c ^@ http://purl.uniprot.org/uniprot/O69678 ^@ Region ^@ Domain Extent ^@ Exonuclease ^@ http://togogenome.org/gene/83332:Rv0942 ^@ http://purl.uniprot.org/uniprot/P9WKN9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0942 ^@ http://purl.uniprot.org/annotation/PRO_0000103745 http://togogenome.org/gene/83332:Rv2697c ^@ http://purl.uniprot.org/uniprot/P9WNS5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Deoxyuridine 5'-triphosphate nucleotidohydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000182884 http://togogenome.org/gene/83332:Rv3746c ^@ http://purl.uniprot.org/uniprot/Q79FA1 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv3534c ^@ http://purl.uniprot.org/uniprot/P9WMK5 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 4-hydroxy-2-oxohexanoate aldolase|||Abolishes substrate channeling to HsaG.|||Proton acceptor|||Pyruvate carboxyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000387862 http://togogenome.org/gene/83332:Rv1254 ^@ http://purl.uniprot.org/uniprot/Q11064 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Acyl_transf_3|||Helical ^@ http://togogenome.org/gene/83332:Rv1561 ^@ http://purl.uniprot.org/uniprot/P9WFA5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ PINc|||Ribonuclease VapC11 ^@ http://purl.uniprot.org/annotation/PRO_0000103883 http://togogenome.org/gene/83332:Rv3514 ^@ http://purl.uniprot.org/uniprot/Q6MWW6 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1391 ^@ http://purl.uniprot.org/uniprot/P9WNZ1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Coenzyme A biosynthesis bifunctional protein CoaBC ^@ http://purl.uniprot.org/annotation/PRO_0000232694 http://togogenome.org/gene/83332:Rv0022c ^@ http://purl.uniprot.org/uniprot/P71592 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mass ^@ 4Fe-4S Wbl-type|||Fully oxidized recombinant protein tagged at both termini.|||Fully reduced recombinant protein tagged at both termini.|||Transcriptional regulator WhiB5 ^@ http://purl.uniprot.org/annotation/PRO_0000420384 http://togogenome.org/gene/83332:Rv0887c ^@ http://purl.uniprot.org/uniprot/P9WKQ3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Uncharacterized protein Rv0887c|||VOC ^@ http://purl.uniprot.org/annotation/PRO_0000103729 http://togogenome.org/gene/83332:Rv3084 ^@ http://purl.uniprot.org/uniprot/P9WK85 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Motif|||Signal Peptide ^@ Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole|||Putative acetyl-hydrolase LipR ^@ http://purl.uniprot.org/annotation/PRO_0000420877 http://togogenome.org/gene/83332:Rv1216c ^@ http://purl.uniprot.org/uniprot/O05317 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0853c ^@ http://purl.uniprot.org/uniprot/P9WG37 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Alpha-keto-acid decarboxylase ^@ http://purl.uniprot.org/annotation/PRO_0000333751 http://togogenome.org/gene/83332:Rv1325c ^@ http://purl.uniprot.org/uniprot/P9WIF7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||Uncharacterized PE-PGRS family protein PE_PGRS24 ^@ http://purl.uniprot.org/annotation/PRO_0000023577 http://togogenome.org/gene/83332:Rv3768 ^@ http://purl.uniprot.org/uniprot/P72035 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv0281 ^@ http://purl.uniprot.org/uniprot/P9WFI9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0281 ^@ http://purl.uniprot.org/annotation/PRO_0000361239 http://togogenome.org/gene/83332:Rv1511 ^@ http://purl.uniprot.org/uniprot/P71790 ^@ Region ^@ Domain Extent ^@ NAD(P)-bd_dom ^@ http://togogenome.org/gene/83332:Rv3212 ^@ http://purl.uniprot.org/uniprot/O05854 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2693c ^@ http://purl.uniprot.org/uniprot/I6X548 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1683 ^@ http://purl.uniprot.org/uniprot/O33185 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1|||AMP-binding ^@ http://togogenome.org/gene/83332:Rv2182c ^@ http://purl.uniprot.org/uniprot/O53516 ^@ Region ^@ Domain Extent ^@ PlsC ^@ http://togogenome.org/gene/83332:Rv3033 ^@ http://purl.uniprot.org/uniprot/I6YAY5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ DUF4333|||DUF4333 domain-containing protein ^@ http://purl.uniprot.org/annotation/PRO_5010321213 http://togogenome.org/gene/83332:Rv1161 ^@ http://purl.uniprot.org/uniprot/P9WJQ3 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ 4Fe-4S Mo/W bis-MGD-type|||N-acetylthreonine|||Nitrate reductase alpha subunit|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000393357 http://togogenome.org/gene/83332:Rv0245 ^@ http://purl.uniprot.org/uniprot/O53667 ^@ Region ^@ Domain Extent ^@ Flavin_Reduct ^@ http://togogenome.org/gene/83332:Rv3885c ^@ http://purl.uniprot.org/uniprot/P9WJE7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-2 secretion system protein EccE2|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393870 http://togogenome.org/gene/83332:Rv3179 ^@ http://purl.uniprot.org/uniprot/O53329 ^@ Region ^@ Domain Extent ^@ AAA_14|||DUF4143 ^@ http://togogenome.org/gene/83332:Rv1094 ^@ http://purl.uniprot.org/uniprot/P9WNZ5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylalanine|||Putative acyl-[acyl-carrier-protein] desaturase DesA2|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000392676 http://togogenome.org/gene/83332:Rv0581 ^@ http://purl.uniprot.org/uniprot/O53778 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Antitoxin VapB26 ^@ http://purl.uniprot.org/annotation/PRO_0000408071 http://togogenome.org/gene/83332:Rv3715c ^@ http://purl.uniprot.org/uniprot/P9WHI3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Zinc Finger ^@ C4-type|||Recombination protein RecR|||Toprim ^@ http://purl.uniprot.org/annotation/PRO_0000190350 http://togogenome.org/gene/83332:Rv0053 ^@ http://purl.uniprot.org/uniprot/P9WH31 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S6 ^@ http://purl.uniprot.org/annotation/PRO_0000176802 http://togogenome.org/gene/83332:Rv3683 ^@ http://purl.uniprot.org/uniprot/I6X827 ^@ Region ^@ Domain Extent ^@ Metallophos_2 ^@ http://togogenome.org/gene/83332:Rv0907 ^@ http://purl.uniprot.org/uniprot/O05900 ^@ Region ^@ Domain Extent ^@ Beta-lactamase|||DUF3471 ^@ http://togogenome.org/gene/83332:Rv2088 ^@ http://purl.uniprot.org/uniprot/P9WI67 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Decreases phosphorylation.|||Does not affect phosphorylation.|||Does not affect phosphorylation. Lack of phosphorylation; when associated with A-171 and A-173.|||Extracellular|||Helical|||Lack of kinase activity.|||Lack of phosphorylation.|||Lack of phosphorylation; when associated with A-168 and A-171.|||Lack of phosphorylation; when associated with A-168 and A-173.|||Phosphothreonine; by autocatalysis|||Polar residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknJ ^@ http://purl.uniprot.org/annotation/PRO_0000171222 http://togogenome.org/gene/83332:Rv0719 ^@ http://purl.uniprot.org/uniprot/P9WH81 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L6 ^@ http://purl.uniprot.org/annotation/PRO_0000131062 http://togogenome.org/gene/83332:Rv3854c ^@ http://purl.uniprot.org/uniprot/P9WNF9 ^@ Experimental Information|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Mutagenesis Site ^@ ETH-resistant.|||FAD-containing monooxygenase EthA ^@ http://purl.uniprot.org/annotation/PRO_0000398581 http://togogenome.org/gene/83332:Rv0372c ^@ http://purl.uniprot.org/uniprot/O53707 ^@ Region ^@ Domain Extent ^@ XdhC_C|||XdhC_CoxI ^@ http://togogenome.org/gene/83332:Rv1921c ^@ http://purl.uniprot.org/uniprot/O53963 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5030174836 http://togogenome.org/gene/83332:Rv3301c ^@ http://purl.uniprot.org/uniprot/P9WI97 ^@ Molecule Processing ^@ Chain ^@ Phosphate-specific transport system accessory protein PhoU homolog 1 ^@ http://purl.uniprot.org/annotation/PRO_0000155171 http://togogenome.org/gene/83332:Rv0551c ^@ http://purl.uniprot.org/uniprot/O06417 ^@ Molecule Processing ^@ Chain ^@ Medium/long-chain-fatty-acid--CoA ligase FadD8 ^@ http://purl.uniprot.org/annotation/PRO_0000451307 http://togogenome.org/gene/83332:Rv3003c ^@ http://purl.uniprot.org/uniprot/P9WG41 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Acetolactate synthase large subunit IlvB1 ^@ http://purl.uniprot.org/annotation/PRO_0000090803 http://togogenome.org/gene/83332:Rv1028c ^@ http://purl.uniprot.org/uniprot/P9WGL3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Complete loss of autophosphorylation.|||Cytoplasmic|||Extracellular|||Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Sensor protein KdpD ^@ http://purl.uniprot.org/annotation/PRO_0000074773 http://togogenome.org/gene/83332:Rv2210c ^@ http://purl.uniprot.org/uniprot/P9WQ75 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Branched-chain-amino-acid aminotransferase|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000103274 http://togogenome.org/gene/83332:Rv2703 ^@ http://purl.uniprot.org/uniprot/P9WGI1 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||DNA Binding|||Helix|||Motif|||Mutagenesis Site|||Strand|||Turn ^@ Acidic residues|||Basic and acidic residues|||H-T-H motif|||Interaction with polymerase core subunit RpoC|||Loss of interaction with WhiB3.|||Polar residues|||RNA polymerase sigma factor SigA ^@ http://purl.uniprot.org/annotation/PRO_0000093901 http://togogenome.org/gene/83332:Rv1450c ^@ http://purl.uniprot.org/uniprot/Q79FP2 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3054c ^@ http://purl.uniprot.org/uniprot/P95105 ^@ Region ^@ Domain Extent ^@ FMN_red ^@ http://togogenome.org/gene/83332:Rv2037c ^@ http://purl.uniprot.org/uniprot/L0TB61 ^@ Region|||Site ^@ Active Site|||Domain Extent|||Motif ^@ DGA/G|||GXGXXG|||GXSXG|||Nucleophile|||PNPLA|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2878c ^@ http://purl.uniprot.org/uniprot/P9WG65 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Disulfide Bond|||Helix|||Signal Peptide|||Strand ^@ Redox-active|||Soluble secreted antigen MPT53 ^@ http://purl.uniprot.org/annotation/PRO_0000034290 http://togogenome.org/gene/83332:Rv2529 ^@ http://purl.uniprot.org/uniprot/P95024 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ ERCC4|||ERCC4 domain-containing protein|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5010292086 http://togogenome.org/gene/83332:Rv3721c ^@ http://purl.uniprot.org/uniprot/P9WNT9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||DNA polymerase III subunit gamma/tau ^@ http://purl.uniprot.org/annotation/PRO_0000105500 http://togogenome.org/gene/83332:Rv0954 ^@ http://purl.uniprot.org/uniprot/P9WIR9 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ 34 kDa antigenic protein homolog|||Helical|||N-acetylthreonine|||Polar residues|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000064364 http://togogenome.org/gene/83332:Rv2707 ^@ http://purl.uniprot.org/uniprot/I6YE67 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3875 ^@ http://purl.uniprot.org/uniprot/P9WNK7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Coiled-Coil|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ 16% reduction in liposome disruption.|||40% reduction in liposome disruption. 80% reduction; when associated with 2-T--G-10.|||40% reduction in liposome disruption. 80% reduction; when associated with 86-T--A-95.|||40% reduction in liposome disruption. 88% reduction in liposome disruption; when associated with E-17. Reduced liposome disruption; when associated with T-38.|||6 kDa early secretory antigenic target|||88% reduction in liposome disruption; when associated with 25-T-A-26.|||Abolishes EsxB-EsxA heterodimer interaction with EccCb1, maintains interaction with EspA, EccA2 and EccE2.|||Bacteria no longer gain access to host cytoplasm via phagosomal rupture.|||Cannot be overproduced and purified.|||Does not restore virulence in an esxA deletion strain, decreased secretion of EsxA and EsxB.|||Does not restore virulence in an esxA deletion strain, wild-type secretion of EsxA and EsxB (PubMed:16048998). Partially inhibits host TLR2-signaling (PubMed:17486091).|||Does not restore virulence in an esxA deletion strain, wild-type secretion of EsxA and EsxB but no complex formed (PubMed:16048998). No effect on host TLR2-signaling.|||Does not restore virulence in an esxA deletion strain, wild-type secretion of EsxA and EsxB.|||Helical|||N-acetylthreonine; partial|||NBD-linked protein does not fluoresce at acidic pH in presence of liposomes, this residue may face inwards in membranes away from lipids.|||NBD-linked protein fluoresces at acidic pH in presence of liposomes, suggests this residue faces lipids.|||NBD-linked protein moderately fluoresces at acidic pH in presence of liposomes, suggests this residue is partially within membrane.|||No longer inhibits host TLR2-signaling (PubMed:17486091). Does not interact with host B2M, does not decrease B2M cell surface expression, no defects in antigen presentation (PubMed:25356553).|||No longer inhibits host TLR2-signaling.|||Partially restores virulence in an esxA deletion strain, wild-type secretion of EsxA and EsxB (PubMed:16048998). Partially inhibits host TLR2-signaling (PubMed:17486091).|||Reduced liposome disruption; when associated with 25-T-A-26.|||Removed|||Wild-type virulence in an esxA deletion strain.|||Wild-type virulence in an esxA deletion strain; protein should not be acetylated. ^@ http://purl.uniprot.org/annotation/PRO_0000167793 http://togogenome.org/gene/83332:Rv2467 ^@ http://purl.uniprot.org/uniprot/L7N655 ^@ Region ^@ Domain Extent ^@ ERAP1_C|||Peptidase_M1|||Peptidase_M1_N ^@ http://togogenome.org/gene/83332:Rv0066c ^@ http://purl.uniprot.org/uniprot/O53611 ^@ Site ^@ Binding Site ^@ ^@ http://togogenome.org/gene/83332:Rv1609 ^@ http://purl.uniprot.org/uniprot/P9WFX3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Anthranilate synthase component 1 ^@ http://purl.uniprot.org/annotation/PRO_0000154099 http://togogenome.org/gene/83332:Rv2989 ^@ http://purl.uniprot.org/uniprot/O53238 ^@ Region ^@ Domain Extent ^@ HTH iclR-type|||IclR-ED ^@ http://togogenome.org/gene/83332:Rv1264 ^@ http://purl.uniprot.org/uniprot/P9WMU9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 7-fold increase in holoenzyme adenylyl cyclase activity at pH 8.0.|||Almost complete loss of adenylyl cyclase activity in the catalytic fragment.|||Guanylate cyclase|||Higher activity above pH 7.0.|||Loss of adenylyl cyclase activity in the catalytic fragment.|||Loss of pH regulation.|||N-acetylthreonine|||No change in holoenzyme activity.|||Obviates pH regulation.|||Partially relieves high pH inhibition.|||Removed|||Retains 10% adenylyl cyclase activity in the catalytic fragment.|||Shifts activation towards acidic pH.|||pH-sensitive adenylate cyclase Rv1264 ^@ http://purl.uniprot.org/annotation/PRO_0000074131 http://togogenome.org/gene/83332:Rv3580c ^@ http://purl.uniprot.org/uniprot/P9WFW1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ 'HIGH' region|||'KMSKS' region|||Cysteine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000159441 http://togogenome.org/gene/83332:Rv2100 ^@ http://purl.uniprot.org/uniprot/P9WLJ3 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2100 ^@ http://purl.uniprot.org/annotation/PRO_0000014124 http://togogenome.org/gene/83332:Rv1078 ^@ http://purl.uniprot.org/uniprot/P9WIM7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||Proline-rich antigen homolog|||RDD ^@ http://purl.uniprot.org/annotation/PRO_0000058567 http://togogenome.org/gene/83332:Rv1931c ^@ http://purl.uniprot.org/uniprot/P95283 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH araC/xylS-type|||HTH-type transcriptional regulator Rv1931c ^@ http://purl.uniprot.org/annotation/PRO_0000438537 http://togogenome.org/gene/83332:Rv0033 ^@ http://purl.uniprot.org/uniprot/I6WX95 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv0897c ^@ http://purl.uniprot.org/uniprot/P9WKP7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0897c ^@ http://purl.uniprot.org/annotation/PRO_0000103737 http://togogenome.org/gene/83332:Rv3094c ^@ http://purl.uniprot.org/uniprot/O05773 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_2|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv3778c ^@ http://purl.uniprot.org/uniprot/P9WQ67 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Uncharacterized protein Rv3778c ^@ http://purl.uniprot.org/annotation/PRO_0000415516 http://togogenome.org/gene/83332:Rv1555 ^@ http://purl.uniprot.org/uniprot/P9WNB5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Fumarate reductase subunit D|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000196547 http://togogenome.org/gene/83332:Rv2406c ^@ http://purl.uniprot.org/uniprot/P71737 ^@ Region ^@ Domain Extent ^@ CBS ^@ http://togogenome.org/gene/83332:Rv1880c ^@ http://purl.uniprot.org/uniprot/P9WPL9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 140|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052302 http://togogenome.org/gene/83332:Rv1521 ^@ http://purl.uniprot.org/uniprot/P9WQ45 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative fatty-acid--CoA ligase fadD25 ^@ http://purl.uniprot.org/annotation/PRO_0000193137 http://togogenome.org/gene/83332:Rv2047c ^@ http://purl.uniprot.org/uniprot/P9WIH5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2047c ^@ http://purl.uniprot.org/annotation/PRO_0000147101 http://togogenome.org/gene/83332:Rv3043c ^@ http://purl.uniprot.org/uniprot/P9WP71 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Crosslink|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ 1'-histidyl-3'-tyrosine (His-Tyr)|||Helical|||N-acetylthreonine|||Probable cytochrome c oxidase subunit 1|||Removed|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000183443 http://togogenome.org/gene/83332:Rv2192c ^@ http://purl.uniprot.org/uniprot/P9WFX5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Anthranilate phosphoribosyltransferase|||N-acetylalanine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000154461 http://togogenome.org/gene/83332:Rv1077 ^@ http://purl.uniprot.org/uniprot/P9WP51 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink|||Modified Residue ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N6-(pyridoxal phosphate)lysine|||Probable cystathionine beta-synthase Rv1077 ^@ http://purl.uniprot.org/annotation/PRO_0000395885 http://togogenome.org/gene/83332:Rv3897c ^@ http://purl.uniprot.org/uniprot/O07036 ^@ Region ^@ Compositionally Biased Region ^@ Pro residues ^@ http://togogenome.org/gene/83332:Rv1106c ^@ http://purl.uniprot.org/uniprot/P9WQP7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000403957 http://togogenome.org/gene/83332:Rv2845c ^@ http://purl.uniprot.org/uniprot/P9WFT9 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Proline--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000139336 http://togogenome.org/gene/83332:Rv3726 ^@ http://purl.uniprot.org/uniprot/O69693 ^@ Region ^@ Domain Extent ^@ ADH_N|||ADH_zinc_N ^@ http://togogenome.org/gene/83332:Rv0593 ^@ http://purl.uniprot.org/uniprot/I6Y461 ^@ Region ^@ Domain Extent ^@ Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv3693 ^@ http://purl.uniprot.org/uniprot/O69661 ^@ Region ^@ Domain Extent ^@ DUF58 ^@ http://togogenome.org/gene/83332:Rv0557 ^@ http://purl.uniprot.org/uniprot/P9WMY5 ^@ Molecule Processing ^@ Chain ^@ GDP-mannose-dependent alpha-mannosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000393729 http://togogenome.org/gene/83332:Rv0919 ^@ http://purl.uniprot.org/uniprot/I6XA42 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv0729 ^@ http://purl.uniprot.org/uniprot/I6Y4K0 ^@ Region ^@ Domain Extent ^@ FGGY_C|||FGGY_N ^@ http://togogenome.org/gene/83332:Rv3864 ^@ http://purl.uniprot.org/uniprot/P9WJD3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||ESX-1 secretion-associated protein EspE|||Helical|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000393950 http://togogenome.org/gene/83332:Rv0384c ^@ http://purl.uniprot.org/uniprot/P9WPD1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Coiled-Coil|||Domain Extent|||Helix|||Strand|||Turn ^@ Chaperone protein ClpB|||Clp R ^@ http://purl.uniprot.org/annotation/PRO_0000191146 http://togogenome.org/gene/83332:Rv1226c ^@ http://purl.uniprot.org/uniprot/O33222 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||bPH_2 ^@ http://togogenome.org/gene/83332:Rv1399c ^@ http://purl.uniprot.org/uniprot/P9WK87 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Initiator Methionine|||Modified Residue|||Motif ^@ Carboxylesterase NlhH|||Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000419169 http://togogenome.org/gene/83332:Rv3109 ^@ http://purl.uniprot.org/uniprot/P9WJS3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ GTP 3',8-cyclase 1|||Radical SAM core ^@ http://purl.uniprot.org/annotation/PRO_0000152976 http://togogenome.org/gene/83332:Rv1892 ^@ http://purl.uniprot.org/uniprot/O07740 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2220 ^@ http://purl.uniprot.org/uniprot/P9WN39 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ GS beta-grasp|||GS catalytic|||Glutamine synthetase|||O-AMP-tyrosine|||Removed|||Unable to be adenylylated. ^@ http://purl.uniprot.org/annotation/PRO_0000153246 http://togogenome.org/gene/83332:Rv2747 ^@ http://purl.uniprot.org/uniprot/O33289 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Mass|||Strand|||Turn ^@ Amino-acid acetyltransferase|||N-acetyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000420585 http://togogenome.org/gene/83332:Rv0858c ^@ http://purl.uniprot.org/uniprot/P9WPZ5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||Probable N-succinyldiaminopimelate aminotransferase DapC ^@ http://purl.uniprot.org/annotation/PRO_0000414591 http://togogenome.org/gene/83332:Rv1508A ^@ http://purl.uniprot.org/uniprot/Q79FN0 ^@ Region ^@ Domain Extent ^@ NAD(P)-bd_dom ^@ http://togogenome.org/gene/83332:Rv3064c ^@ http://purl.uniprot.org/uniprot/I6XG31 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2890c ^@ http://purl.uniprot.org/uniprot/P9WH39 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 30S ribosomal protein S2|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000134203 http://togogenome.org/gene/83332:Rv3411c ^@ http://purl.uniprot.org/uniprot/P9WKI7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ CBS 1|||CBS 2|||Inosine-5'-monophosphate dehydrogenase|||Proton acceptor|||Thioimidate intermediate|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000093702 http://togogenome.org/gene/83332:Rv2717c ^@ http://purl.uniprot.org/uniprot/P9WFG7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Motif|||Strand|||Turn ^@ GXWXGXG|||Peroxynitrite isomerase 1|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000356934 http://togogenome.org/gene/83332:Rv3562 ^@ http://purl.uniprot.org/uniprot/I6YGH7 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv2579 ^@ http://purl.uniprot.org/uniprot/P9WMR9 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ AB hydrolase-1|||Haloalkane dehalogenase 3|||N-acetylthreonine|||Nucleophile|||Proton acceptor|||Proton donor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000216783 http://togogenome.org/gene/83332:Rv0076c ^@ http://purl.uniprot.org/uniprot/O53621 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3193c ^@ http://purl.uniprot.org/uniprot/P9WFL3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||UPF0182 protein Rv3193c ^@ http://purl.uniprot.org/annotation/PRO_0000157724 http://togogenome.org/gene/83332:Rv1839c ^@ http://purl.uniprot.org/uniprot/P9WJ51 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB13 ^@ http://purl.uniprot.org/annotation/PRO_0000408060 http://togogenome.org/gene/83332:Rv1619 ^@ http://purl.uniprot.org/uniprot/O06136 ^@ Molecule Processing|||Region ^@ Chain|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Helical|||MprF-like domain protein Rv1619|||Periplasmic ^@ http://purl.uniprot.org/annotation/PRO_0000456585 http://togogenome.org/gene/83332:Rv3001c ^@ http://purl.uniprot.org/uniprot/P9WKJ7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Strand|||Turn ^@ KARI C-terminal knotted|||KARI N-terminal Rossmann|||Ketol-acid reductoisomerase (NADP(+))|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000151329 http://togogenome.org/gene/83332:Rv0250c ^@ http://purl.uniprot.org/uniprot/O53672 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylserine|||Removed|||Uncharacterized protein Rv0250c ^@ http://purl.uniprot.org/annotation/PRO_0000403670 http://togogenome.org/gene/83332:Rv3378c ^@ http://purl.uniprot.org/uniprot/P9WJ61 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes transferase activity.|||Abolishes transferase activity. Decrease in TOH production. Almost loss of iso-TOH production.|||Decrease in TOH production and almost loss of iso-TOH production. Almost loss of TOH and TOH production; when associated with F-51.|||Does not affect TOH production. Strong decrease in iso-TOH production.|||Significant decrease in phosphatase activity. Loss of phosphatase activity; when associated with N-81 or N-82.|||Significant decrease in phosphatase activity. Loss of phosphatase activity; when associated with N-81 or N-85.|||Significant decrease in phosphatase activity. Loss of phosphatase activity; when associated with N-82 or N-85.|||Strong decrease in TOH and iso-TOH production. Almost loss of TOH and TOH production; when associated with F-90.|||Tuberculosinyl adenosine transferase ^@ http://purl.uniprot.org/annotation/PRO_0000416456 http://togogenome.org/gene/83332:Rv3877 ^@ http://purl.uniprot.org/uniprot/P9WNQ7 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Initiator Methionine|||Modified Residue|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||ESX-1 secretion system protein EccD1|||Helical|||N-acetylserine|||Periplasmic|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000393233 http://togogenome.org/gene/83332:Rv2835c ^@ http://purl.uniprot.org/uniprot/I6XFF3 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv0044c ^@ http://purl.uniprot.org/uniprot/P71701 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv0562 ^@ http://purl.uniprot.org/uniprot/O06428 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif|||Mutagenesis Site ^@ DDXXD motif|||Leads to the appearance of shorter chain products, GPP and E,E-FPP, with only small amounts of GGPP produced.|||Nonaprenyl diphosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000451297 http://togogenome.org/gene/83332:Rv1734c ^@ http://purl.uniprot.org/uniprot/P9WLS7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1734c ^@ http://purl.uniprot.org/annotation/PRO_0000392907 http://togogenome.org/gene/83332:Rv2230c ^@ http://purl.uniprot.org/uniprot/P9WFM1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ GTP cyclohydrolase 1 type 2 homolog ^@ http://purl.uniprot.org/annotation/PRO_0000147318 http://togogenome.org/gene/83332:Rv2596 ^@ http://purl.uniprot.org/uniprot/P9WF61 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC40 ^@ http://purl.uniprot.org/annotation/PRO_0000014142 http://togogenome.org/gene/83332:Rv0700 ^@ http://purl.uniprot.org/uniprot/P9WH67 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S10 ^@ http://purl.uniprot.org/annotation/PRO_0000146560 http://togogenome.org/gene/83332:Rv1568 ^@ http://purl.uniprot.org/uniprot/P9WQ81 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Adenosylmethionine-8-amino-7-oxononanoate aminotransferase|||Does not show detectable activity at 335 nm with SAM, even up to concentrations of 3 mM, and shows approximately 70% reduced activity with high concentrations of DAPA (0.5 mM).|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000120374 http://togogenome.org/gene/83332:Rv3790 ^@ http://purl.uniprot.org/uniprot/P9WJF1 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Sequence Variant|||Strand|||Turn ^@ Confers resistance to BTZ043 and PBTZ169. Decreases M.tuberculosis cytotoxicity in macrophages. Does not affect binding affinity of the substrate to the enzyme, and only slightly affects catalytic efficiency. Is only partially inhibited by PBTZ169 at high concentrations, while totally inhibited by the non-covalent inhibitor Ty38c.|||Confers resistance to BTZ043 and PBTZ169. Decreases M.tuberculosis cytotoxicity in macrophages. Does not affect binding affinity of the substrate to the enzyme, but reduces catalytic efficiency by 4-fold. Is only partially inhibited by PBTZ169 at high concentrations, while totally inhibited by the non-covalent inhibitor Ty38c.|||Confers resistance to BTZ043 and PBTZ169. Loss of covalent modification with BTZ043. Decreases M.tuberculosis cytotoxicity in macrophages. Does not affect binding affinity of the substrate to the enzyme, but reduces catalytic efficiency by 4-fold. Is only partially inhibited by PBTZ169 at high concentrations, while nearly totally inhibited by the non-covalent inhibitor Ty38c.|||Decaprenylphosphoryl-beta-D-ribose oxidase|||FAD-binding PCMH-type|||In a spontaneous TCA1-resistant mutant strain, but sensitive to BTZ.|||In strain: NTB1; BTZ043-resistant.|||In strain: NTB9; BTZ043-resistant.|||In strain: TRC11; Ty38c-resistant mutant strain lacking Rv3406, but sensitive to moxifloxacin.|||In strain: TRC12; Ty38c-resistant mutant strain lacking Rv3406, but sensitive to moxifloxacin.|||Significantly less susceptible to Ty38c inhibition. 34-fold reduction in catalytic activity.|||Significantly less susceptible to Ty38c inhibition. 7-fold reduction in catalytic activity. ^@ http://purl.uniprot.org/annotation/PRO_0000390891 http://togogenome.org/gene/83332:Rv2417c ^@ http://purl.uniprot.org/uniprot/P9WP05 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ DegV|||DegV domain-containing protein Rv2417c ^@ http://purl.uniprot.org/annotation/PRO_0000209778 http://togogenome.org/gene/83332:Rv2058c ^@ http://purl.uniprot.org/uniprot/P9WHA9 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L28-2 ^@ http://purl.uniprot.org/annotation/PRO_0000178513 http://togogenome.org/gene/83332:Rv3237c ^@ http://purl.uniprot.org/uniprot/O05882 ^@ Region ^@ Domain Extent ^@ RCK C-terminal ^@ http://togogenome.org/gene/83332:Rv2235 ^@ http://purl.uniprot.org/uniprot/P9WGA7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized SURF1-like protein Rv2235 ^@ http://purl.uniprot.org/annotation/PRO_0000215662 http://togogenome.org/gene/83332:Rv2202c ^@ http://purl.uniprot.org/uniprot/P9WID5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Adenosine kinase|||N-acetylthreonine|||Proton acceptor|||Removed|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000080064 http://togogenome.org/gene/83332:Rv2770c ^@ http://purl.uniprot.org/uniprot/P9WHZ3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE44 ^@ http://purl.uniprot.org/annotation/PRO_0000379590 http://togogenome.org/gene/83332:Rv0964c ^@ http://purl.uniprot.org/uniprot/P9WKM5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0964c ^@ http://purl.uniprot.org/annotation/PRO_0000103762 http://togogenome.org/gene/83332:Rv1155a ^@ http://purl.uniprot.org/uniprot/A0A089QKZ7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Uncharacterized protein Rv1155A ^@ http://purl.uniprot.org/annotation/PRO_0000434780 http://togogenome.org/gene/83332:Rv3908 ^@ http://purl.uniprot.org/uniprot/P9WIX7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ Nudix box|||Nudix hydrolase|||Putative mutator protein MutT4 ^@ http://purl.uniprot.org/annotation/PRO_0000392934 http://togogenome.org/gene/83332:Rv1630 ^@ http://purl.uniprot.org/uniprot/P9WH43 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 2.5-fold decrease in binding of POA, decreased binding of tmRNA (expressed as residues 285-481).|||2.7-fold decrease in binding of POA, decreased binding of tmRNA (expressed as residues 285-481).|||3-fold decrease in binding of POA, decreased binding of tmRNA (expressed as residues 285-481).|||30S ribosomal protein S1|||Complete loss of POA binding, significantly decreased binding of tmRNA (expressed as residues 285-481).|||Does not bind POA. Binds tmRNA less strongly than wild-type, binding is not disrupted by POA.|||Polar residues|||S1 motif 1|||S1 motif 2|||S1 motif 3|||S1 motif 4 ^@ http://purl.uniprot.org/annotation/PRO_0000196042 http://togogenome.org/gene/83332:Rv0603 ^@ http://purl.uniprot.org/uniprot/O07775 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010314127 http://togogenome.org/gene/83332:Rv2858c ^@ http://purl.uniprot.org/uniprot/O33340 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Aldedh ^@ http://togogenome.org/gene/83332:Rv3736 ^@ http://purl.uniprot.org/uniprot/O69703 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH araC/xylS-type ^@ http://togogenome.org/gene/83332:Rv3653 ^@ http://purl.uniprot.org/uniprot/Q6MWV0 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ Decreases Ca(2+) binding affinity.|||PE-PGRS family protein PE_PGRS61 ^@ http://purl.uniprot.org/annotation/PRO_0000438250 http://togogenome.org/gene/83332:Rv1269c ^@ http://purl.uniprot.org/uniprot/P9WM45 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Protein Rv1269c|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000014089 http://togogenome.org/gene/83332:Rv0401 ^@ http://purl.uniprot.org/uniprot/P95210 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1236 ^@ http://purl.uniprot.org/uniprot/P9WG03 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Trehalose transport system permease protein SugA ^@ http://purl.uniprot.org/annotation/PRO_0000419315 http://togogenome.org/gene/83332:Rv0221 ^@ http://purl.uniprot.org/uniprot/P9WKB7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv0221 ^@ http://purl.uniprot.org/annotation/PRO_0000222905 http://togogenome.org/gene/83332:Rv1409 ^@ http://purl.uniprot.org/uniprot/P9WPH1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ CMP/dCMP-type deaminase|||Proton donor|||Riboflavin biosynthesis protein RibD ^@ http://purl.uniprot.org/annotation/PRO_0000171723 http://togogenome.org/gene/83332:Rv3136A ^@ http://purl.uniprot.org/uniprot/I6Y2Q7 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1057 ^@ http://purl.uniprot.org/uniprot/O53405 ^@ Molecule Processing ^@ Chain ^@ Seven-bladed beta-propeller protein Rv1057 ^@ http://purl.uniprot.org/annotation/PRO_0000451064 http://togogenome.org/gene/83332:Rv1902c ^@ http://purl.uniprot.org/uniprot/O07730 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MFS ^@ http://togogenome.org/gene/83332:Rv2758c ^@ http://purl.uniprot.org/uniprot/P9WJ43 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB21 ^@ http://purl.uniprot.org/annotation/PRO_0000408067 http://togogenome.org/gene/83332:Rv1240 ^@ http://purl.uniprot.org/uniprot/P9WK13 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Malate dehydrogenase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000113380 http://togogenome.org/gene/83332:Rv3421c ^@ http://purl.uniprot.org/uniprot/P9WKY7 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv3421c ^@ http://purl.uniprot.org/annotation/PRO_0000014153 http://togogenome.org/gene/83332:Rv3387 ^@ http://purl.uniprot.org/uniprot/O50414 ^@ Region ^@ Domain Extent ^@ DDE_Tnp_1 ^@ http://togogenome.org/gene/83332:Rv0627 ^@ http://purl.uniprot.org/uniprot/P96917 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ PINc|||Ribonuclease VapC5 ^@ http://purl.uniprot.org/annotation/PRO_0000407868 http://togogenome.org/gene/83332:Rv2384 ^@ http://purl.uniprot.org/uniprot/P71716 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Salicyl-AMP ligase / salicyl-S-ArCP synthetase ^@ http://purl.uniprot.org/annotation/PRO_0000445644 http://togogenome.org/gene/83332:Rv3573c ^@ http://purl.uniprot.org/uniprot/P96855 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ Acyl-CoA dehydrogenase FadE34|||Displays less than 1% activity with cholyl-CoA as substrate. Still binds FAD.|||Displays less than 2% activity with cholyl-CoA as substrate. Cannot bind FAD. ^@ http://purl.uniprot.org/annotation/PRO_0000438519 http://togogenome.org/gene/83332:Rv2677c ^@ http://purl.uniprot.org/uniprot/P9WMP1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Coproporphyrinogen III oxidase ^@ http://purl.uniprot.org/annotation/PRO_0000135265 http://togogenome.org/gene/83332:Rv3203 ^@ http://purl.uniprot.org/uniprot/L0TC47 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ Charge relay system|||Lipase LipV|||Loss of enzymatic activity.|||Loss of more than 70% enzymatic activity.|||No effect on enzymatic activity.|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000432515 http://togogenome.org/gene/83332:Rv0086 ^@ http://purl.uniprot.org/uniprot/Q10883 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Proton_antipo_M ^@ http://togogenome.org/gene/83332:Rv0450c ^@ http://purl.uniprot.org/uniprot/P9WJV3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Siderophore exporter MmpL4 ^@ http://purl.uniprot.org/annotation/PRO_0000103566 http://togogenome.org/gene/83332:Rv1851 ^@ http://purl.uniprot.org/uniprot/P9WFE5 ^@ Molecule Processing ^@ Chain ^@ Urease accessory protein UreF ^@ http://purl.uniprot.org/annotation/PRO_0000067651 http://togogenome.org/gene/83332:Rv3012c ^@ http://purl.uniprot.org/uniprot/P9WN59 ^@ Molecule Processing ^@ Chain ^@ Glutamyl-tRNA(Gln) amidotransferase subunit C ^@ http://purl.uniprot.org/annotation/PRO_0000105312 http://togogenome.org/gene/83332:Rv0263c ^@ http://purl.uniprot.org/uniprot/P95220 ^@ Region ^@ Domain Extent ^@ AHS2 ^@ http://togogenome.org/gene/83332:Rv3392c ^@ http://purl.uniprot.org/uniprot/P9WPB7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Cyclopropane mycolic acid synthase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000089566 http://togogenome.org/gene/83332:Rv3887c ^@ http://purl.uniprot.org/uniprot/P9WNQ5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-2 secretion system protein eccD2|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393234 http://togogenome.org/gene/83332:Rv0740 ^@ http://purl.uniprot.org/uniprot/O53803 ^@ Molecule Processing ^@ Chain ^@ Protein Rv0740 ^@ http://purl.uniprot.org/annotation/PRO_0000432517 http://togogenome.org/gene/83332:Rv2782c ^@ http://purl.uniprot.org/uniprot/P9WHT5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized zinc protease Rv2782c ^@ http://purl.uniprot.org/annotation/PRO_0000074423 http://togogenome.org/gene/83332:Rv0572c ^@ http://purl.uniprot.org/uniprot/P9WM81 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic residues|||Uncharacterized protein Rv0572c ^@ http://purl.uniprot.org/annotation/PRO_0000392683 http://togogenome.org/gene/83332:Rv1419 ^@ http://purl.uniprot.org/uniprot/P9WLX9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||Ricin B-type lectin|||Uncharacterized protein Rv1419 ^@ http://purl.uniprot.org/annotation/PRO_0000103845 http://togogenome.org/gene/83332:Rv2607 ^@ http://purl.uniprot.org/uniprot/P9WIJ1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Pyridoxine 5'-phosphate oxidase ^@ http://purl.uniprot.org/annotation/PRO_0000167723 http://togogenome.org/gene/83332:Rv0710 ^@ http://purl.uniprot.org/uniprot/P9WH51 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S17 ^@ http://purl.uniprot.org/annotation/PRO_0000128471 http://togogenome.org/gene/83332:Rv1251c ^@ http://purl.uniprot.org/uniprot/O50466 ^@ Region ^@ Domain Extent ^@ AAA_12|||RNase_H_2 ^@ http://togogenome.org/gene/83332:Rv3801c ^@ http://purl.uniprot.org/uniprot/O53580 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Cannot be phosphorylated. No change in activity.|||Catalyzes the formation of acyl-CoA; when associated with A-383.|||Catalyzes the formation of acyl-CoA; when associated with A-481.|||Confers resistance to the coumarin inhibitors.|||Long-chain-fatty-acid--AMP ligase FadD32|||Phosphomimetic mutant. 55% decrease in activity.|||Phosphothreonine ^@ http://purl.uniprot.org/annotation/PRO_0000406634 http://togogenome.org/gene/83332:Rv2427c ^@ http://purl.uniprot.org/uniprot/P9WHV1 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ Gamma-glutamyl phosphate reductase|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000189753 http://togogenome.org/gene/83332:Rv2069 ^@ http://purl.uniprot.org/uniprot/P9WGH1 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif|||Mutagenesis Site|||Turn ^@ Blue shift in fluorescence emission, possible decrease in -10 promoter recognition.|||ECF RNA polymerase sigma factor SigC|||H-T-H motif|||Polymerase core binding|||Red shift in fluorescence emission. ^@ http://purl.uniprot.org/annotation/PRO_0000094021 http://togogenome.org/gene/83332:Rv1651c ^@ http://purl.uniprot.org/uniprot/Q79FL8 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS30 ^@ http://purl.uniprot.org/annotation/PRO_5004287725 http://togogenome.org/gene/83332:Rv2245 ^@ http://purl.uniprot.org/uniprot/P9WQD9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 3-oxoacyl-[acyl-carrier-protein] synthase 1|||For beta-ketoacyl synthase activity|||Increases resistance to isoniazid.|||Ketosynthase family 3 (KS3)|||Loss of activity with hexadecanoyl-CoA.|||Mimics structural changes caused by acyl-enzyme formation. ^@ http://purl.uniprot.org/annotation/PRO_0000180333 http://togogenome.org/gene/83332:Rv0151c ^@ http://purl.uniprot.org/uniprot/Q79G06 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||PE|||PE-PPE ^@ http://togogenome.org/gene/83332:Rv2901c ^@ http://purl.uniprot.org/uniprot/P9WL27 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylserine|||Removed|||Uncharacterized protein Rv2901c ^@ http://purl.uniprot.org/annotation/PRO_0000104096 http://togogenome.org/gene/83332:Rv0143c ^@ http://purl.uniprot.org/uniprot/P96820 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2892c ^@ http://purl.uniprot.org/uniprot/P9WHZ1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized PPE family protein PPE45 ^@ http://purl.uniprot.org/annotation/PRO_0000217850 http://togogenome.org/gene/83332:Rv3070 ^@ http://purl.uniprot.org/uniprot/P9WP61 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative fluoride ion transporter CrcB 2 ^@ http://purl.uniprot.org/annotation/PRO_0000110138 http://togogenome.org/gene/83332:Rv2727c ^@ http://purl.uniprot.org/uniprot/P9WJW1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ tRNA dimethylallyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000163942 http://togogenome.org/gene/83332:Rv1243c ^@ http://purl.uniprot.org/uniprot/Q79FQ7 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1360 ^@ http://purl.uniprot.org/uniprot/P9WM03 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1360 ^@ http://purl.uniprot.org/annotation/PRO_0000014099 http://togogenome.org/gene/83332:Rv3919c ^@ http://purl.uniprot.org/uniprot/P9WGW9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Ribosomal RNA small subunit methyltransferase G ^@ http://purl.uniprot.org/annotation/PRO_0000184283 http://togogenome.org/gene/83332:Rv2545 ^@ http://purl.uniprot.org/uniprot/P9WJ47 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB18 ^@ http://purl.uniprot.org/annotation/PRO_0000408064 http://togogenome.org/gene/83332:Rv3403c ^@ http://purl.uniprot.org/uniprot/P9WKZ5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv3403c ^@ http://purl.uniprot.org/annotation/PRO_0000104123 http://togogenome.org/gene/83332:Rv2869c ^@ http://purl.uniprot.org/uniprot/P9WHS3 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Mutagenesis Site|||Transmembrane ^@ Helical|||Loss of PbpB (PBP3, FtsI) processing.|||No effect on PbpB (PBP3, FtsI) processing.|||PDZ|||Zinc metalloprotease Rip1 ^@ http://purl.uniprot.org/annotation/PRO_0000088449 http://togogenome.org/gene/83332:Rv3749c ^@ http://purl.uniprot.org/uniprot/L0TGF0 ^@ Molecule Processing ^@ Chain ^@ Putative ribonuclease VapC50 ^@ http://purl.uniprot.org/annotation/PRO_0000433057 http://togogenome.org/gene/83332:Rv2374c ^@ http://purl.uniprot.org/uniprot/P9WMK3 ^@ Molecule Processing ^@ Chain ^@ Heat-inducible transcription repressor HrcA ^@ http://purl.uniprot.org/annotation/PRO_0000182512 http://togogenome.org/gene/83332:Rv3784 ^@ http://purl.uniprot.org/uniprot/P72050 ^@ Region ^@ Domain Extent ^@ NAD(P)-bd_dom ^@ http://togogenome.org/gene/83332:Rv0090 ^@ http://purl.uniprot.org/uniprot/P9WM71 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0090 ^@ http://purl.uniprot.org/annotation/PRO_0000103664 http://togogenome.org/gene/83332:Rv0411c ^@ http://purl.uniprot.org/uniprot/P96257 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Disulfide Bond|||Domain Extent|||Signal Peptide ^@ PBPb ^@ http://purl.uniprot.org/annotation/PRO_5010314129 http://togogenome.org/gene/83332:Rv1279 ^@ http://purl.uniprot.org/uniprot/P9WMV5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized GMC-type oxidoreductase Rv1279 ^@ http://purl.uniprot.org/annotation/PRO_0000205616 http://togogenome.org/gene/83332:Rv0056 ^@ http://purl.uniprot.org/uniprot/P9WH79 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L9 ^@ http://purl.uniprot.org/annotation/PRO_0000176655 http://togogenome.org/gene/83332:Rv1758 ^@ http://purl.uniprot.org/uniprot/O06793 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Disulfide Bond ^@ Nucleophile|||Probable carboxylesterase Culp5|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000450108 http://togogenome.org/gene/83332:Rv0832 ^@ http://purl.uniprot.org/uniprot/Q79FV8 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010190170 http://togogenome.org/gene/83332:Rv0231 ^@ http://purl.uniprot.org/uniprot/P96414 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1 ^@ http://togogenome.org/gene/83332:Rv1590 ^@ http://purl.uniprot.org/uniprot/P9WLT7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1590 ^@ http://purl.uniprot.org/annotation/PRO_0000103888 http://togogenome.org/gene/83332:Rv1069c ^@ http://purl.uniprot.org/uniprot/O53417 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Abhydrolase_9|||Abhydrolase_9_N|||Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1912c ^@ http://purl.uniprot.org/uniprot/O07721 ^@ Region ^@ Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv2772c ^@ http://purl.uniprot.org/uniprot/I6YA75 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0285 ^@ http://purl.uniprot.org/uniprot/L7N695 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand ^@ PE|||PE family immunomodulator PE5 ^@ http://purl.uniprot.org/annotation/PRO_5007687871 http://togogenome.org/gene/83332:Rv1726 ^@ http://purl.uniprot.org/uniprot/P71984 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv2567 ^@ http://purl.uniprot.org/uniprot/P9WL97 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2567 ^@ http://purl.uniprot.org/annotation/PRO_0000104044 http://togogenome.org/gene/83332:Rv3435c ^@ http://purl.uniprot.org/uniprot/O06252 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0359 ^@ http://purl.uniprot.org/uniprot/L0T550 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ Helical|||Putative zinc metalloprotease Rip2 ^@ http://purl.uniprot.org/annotation/PRO_0000422678 http://togogenome.org/gene/83332:Rv1536 ^@ http://purl.uniprot.org/uniprot/P9WFV3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ 'HIGH' region|||'KMSKS' region|||Isoleucine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000098550 http://togogenome.org/gene/83332:Rv2398c ^@ http://purl.uniprot.org/uniprot/P71746 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv3585 ^@ http://purl.uniprot.org/uniprot/P9WHJ9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif|||Zinc Finger ^@ C4-type|||DNA repair protein RadA|||RadA KNRFG motif ^@ http://purl.uniprot.org/annotation/PRO_0000187932 http://togogenome.org/gene/83332:Rv3760 ^@ http://purl.uniprot.org/uniprot/O69726 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Uncharacterized membrane protein Rv3760 ^@ http://purl.uniprot.org/annotation/PRO_0000415510 http://togogenome.org/gene/83332:Rv0462 ^@ http://purl.uniprot.org/uniprot/P9WHH9 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Dihydrolipoyl dehydrogenase|||Proton acceptor|||Redox-active|||Reduces lipoamide dehydrogenase activity by 82%.|||Reduces lipoamide dehydrogenase activity by 89%.|||Reduces lipoamide dehydrogenase activity by 91%.|||Reduces lipoamide dehydrogenase activity by 94%.|||Reduces lipoamide dehydrogenase activity by 95%.|||Reduces lipoamide dehydrogenase activity by 96%. ^@ http://purl.uniprot.org/annotation/PRO_0000068034 http://togogenome.org/gene/83332:Rv1862 ^@ http://purl.uniprot.org/uniprot/P9WQC1 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylvaline|||Probable alcohol dehydrogenase AdhA|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000391341 http://togogenome.org/gene/83332:Rv3899c ^@ http://purl.uniprot.org/uniprot/O05446 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ DUF5631|||DUF5632|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2515c ^@ http://purl.uniprot.org/uniprot/I6XEH5 ^@ Region ^@ Domain Extent ^@ HTH cro/C1-type ^@ http://togogenome.org/gene/83332:Rv3708c ^@ http://purl.uniprot.org/uniprot/P9WNX5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Acyl-thioester intermediate|||Aspartate-semialdehyde dehydrogenase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000141383 http://togogenome.org/gene/83332:Rv0939 ^@ http://purl.uniprot.org/uniprot/O86346 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv0583c ^@ http://purl.uniprot.org/uniprot/O53780 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Lipid Binding|||Signal Peptide|||Strand|||Turn ^@ Lipoprotein LpqN|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_5010295865 http://togogenome.org/gene/83332:Rv1429 ^@ http://purl.uniprot.org/uniprot/O06829 ^@ Region ^@ Domain Extent ^@ GGDEF_2|||HTH_30 ^@ http://togogenome.org/gene/83332:Rv3175 ^@ http://purl.uniprot.org/uniprot/O53325 ^@ Region ^@ Domain Extent ^@ Amidase ^@ http://togogenome.org/gene/83332:Rv0760c ^@ http://purl.uniprot.org/uniprot/I6WZD7 ^@ Region ^@ Domain Extent ^@ NTF2 ^@ http://togogenome.org/gene/83332:Rv1261c ^@ http://purl.uniprot.org/uniprot/P9WP13 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ F420H(2)-dependent quinone reductase Rv1261c ^@ http://purl.uniprot.org/annotation/PRO_0000103778 http://togogenome.org/gene/83332:Rv0721 ^@ http://purl.uniprot.org/uniprot/P9WH33 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ 30S ribosomal protein S5|||Basic and acidic residues|||N-acetylalanine|||Removed|||S5 DRBM ^@ http://purl.uniprot.org/annotation/PRO_0000131556 http://togogenome.org/gene/83332:Rv0236A ^@ http://purl.uniprot.org/uniprot/P9WLB1 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Putative secreted protein Rv0236.1 ^@ http://purl.uniprot.org/annotation/PRO_0000014068 http://togogenome.org/gene/83332:Rv2912c ^@ http://purl.uniprot.org/uniprot/P9WMC7 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv2912c ^@ http://purl.uniprot.org/annotation/PRO_0000070668 http://togogenome.org/gene/83332:Rv1546 ^@ http://purl.uniprot.org/uniprot/P9WLU7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1546 ^@ http://purl.uniprot.org/annotation/PRO_0000103876 http://togogenome.org/gene/83332:Rv0155 ^@ http://purl.uniprot.org/uniprot/P96832 ^@ Region ^@ Domain Extent ^@ AlaDh_PNT_C|||AlaDh_PNT_N ^@ http://togogenome.org/gene/83332:Rv1916 ^@ http://purl.uniprot.org/uniprot/O07717 ^@ Molecule Processing ^@ Chain ^@ Putative isocitrate lyase subunit B ^@ http://purl.uniprot.org/annotation/PRO_0000432567 http://togogenome.org/gene/83332:Rv3081 ^@ http://purl.uniprot.org/uniprot/O53298 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv2737c ^@ http://purl.uniprot.org/uniprot/P9WHJ3 ^@ Modification|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Domain Extent|||Helix|||Sequence Variant|||Strand|||Turn ^@ DOD-type homing endonuclease|||Endonuclease PI-MtuI|||In strain: Canetti and SO93.|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Protein RecA, 1st part|||Protein RecA, 2nd part ^@ http://purl.uniprot.org/annotation/PRO_0000030269|||http://purl.uniprot.org/annotation/PRO_0000030270|||http://purl.uniprot.org/annotation/PRO_0000030271 http://togogenome.org/gene/83332:Rv3598c ^@ http://purl.uniprot.org/uniprot/P9WFU9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Lysine--tRNA ligase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000152655 http://togogenome.org/gene/83332:Rv1375 ^@ http://purl.uniprot.org/uniprot/P9WF27 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Uncharacterized protein Rv1375|||YcaO ^@ http://purl.uniprot.org/annotation/PRO_0000144978 http://togogenome.org/gene/83332:Rv2555c ^@ http://purl.uniprot.org/uniprot/P9WFW7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Alanine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000075147 http://togogenome.org/gene/83332:Rv2916c ^@ http://purl.uniprot.org/uniprot/P9WGD7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Basic residues|||Signal recognition particle protein ^@ http://purl.uniprot.org/annotation/PRO_0000101163 http://togogenome.org/gene/83332:Rv2882c ^@ http://purl.uniprot.org/uniprot/P9WGY1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Ribosome-recycling factor ^@ http://purl.uniprot.org/annotation/PRO_0000167500 http://togogenome.org/gene/83332:Rv3413c ^@ http://purl.uniprot.org/uniprot/P9WJ71 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ 10-fold reduction in binding to SigD.|||Anti-sigma-D factor RsdA|||Cytoplasmic|||Extracellular|||Helical|||No proteolysis by ClpP1-ClpP2-ClpX.|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000104133 http://togogenome.org/gene/83332:Rv0274 ^@ http://purl.uniprot.org/uniprot/O53680 ^@ Region ^@ Domain Extent ^@ VOC ^@ http://togogenome.org/gene/83332:Rv3893c ^@ http://purl.uniprot.org/uniprot/L7N660 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv2311 ^@ http://purl.uniprot.org/uniprot/P9WLC1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2311 ^@ http://purl.uniprot.org/annotation/PRO_0000104020 http://togogenome.org/gene/83332:Rv0101 ^@ http://purl.uniprot.org/uniprot/Q10896 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv0951 ^@ http://purl.uniprot.org/uniprot/P9WGC5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ATP-grasp|||Succinate--CoA ligase [ADP-forming] subunit beta ^@ http://purl.uniprot.org/annotation/PRO_0000102840 http://togogenome.org/gene/83332:Rv1289 ^@ http://purl.uniprot.org/uniprot/P9WM37 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1289 ^@ http://purl.uniprot.org/annotation/PRO_0000103787 http://togogenome.org/gene/83332:Rv0421c ^@ http://purl.uniprot.org/uniprot/P96267 ^@ Region ^@ Domain Extent ^@ Abhydrolase_11 ^@ http://togogenome.org/gene/83332:Rv1772 ^@ http://purl.uniprot.org/uniprot/O06805 ^@ Region ^@ Domain Extent ^@ ANTAR ^@ http://togogenome.org/gene/83332:Rv3543c ^@ http://purl.uniprot.org/uniprot/P71858 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ Acyl-CoA dehydrogenase FadE29|||Proton acceptor|||Unable to dehydrogenate pregnene-carboxyl-CoA ester. ^@ http://purl.uniprot.org/annotation/PRO_0000438518 http://togogenome.org/gene/83332:Rv0771 ^@ http://purl.uniprot.org/uniprot/I6Y4S7 ^@ Region ^@ Domain Extent ^@ CMD ^@ http://togogenome.org/gene/83332:Rv0242c ^@ http://purl.uniprot.org/uniprot/I6Y778 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ 12-fold decrease in catalytic efficiency with NADH as substrate. 26-fold decrease in catalytic efficiency; when associated with A-146.|||2.2-fold decrease in catalytic efficiency with NADH as substrate. 26-fold decrease in catalytic efficiency; when associated with A-445.|||3-oxoacyl-[acyl-carrier-protein] reductase [NADH]|||Drastic reduction of ketoreductase activity.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000451898 http://togogenome.org/gene/83332:Rv0731c ^@ http://purl.uniprot.org/uniprot/P9WFI5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0731c ^@ http://purl.uniprot.org/annotation/PRO_0000361243 http://togogenome.org/gene/83332:Rv1601 ^@ http://purl.uniprot.org/uniprot/P9WML9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Imidazoleglycerol-phosphate dehydratase ^@ http://purl.uniprot.org/annotation/PRO_0000158146|||http://purl.uniprot.org/annotation/PRO_0000445482 http://togogenome.org/gene/83332:Rv2439c ^@ http://purl.uniprot.org/uniprot/P9WHU9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Glutamate 5-kinase|||PUA ^@ http://purl.uniprot.org/annotation/PRO_0000109696 http://togogenome.org/gene/83332:Rv3445c ^@ http://purl.uniprot.org/uniprot/I6Y3I6 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxU ^@ http://purl.uniprot.org/annotation/PRO_0000436935 http://togogenome.org/gene/83332:Rv0369c ^@ http://purl.uniprot.org/uniprot/O53704 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2577 ^@ http://purl.uniprot.org/uniprot/P9WL81 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Tat-type signal|||Uncharacterized protein Rv2577 ^@ http://purl.uniprot.org/annotation/PRO_0000104060 http://togogenome.org/gene/83332:Rv2074 ^@ http://purl.uniprot.org/uniprot/P9WLL7 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 17.8-fold decrease in catalytic efficiency.|||2.6-fold decrease in catalytic efficiency.|||2.7-fold decrease in catalytic efficiency.|||3.3-fold decrease in catalytic efficiency.|||4.7-fold decrease in catalytic efficiency.|||44.5-fold decrease in catalytic efficiency.|||8.9-fold decrease in catalytic efficiency.|||F420H(2)-dependent biliverdin reductase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000103945 http://togogenome.org/gene/83332:Rv1386 ^@ http://purl.uniprot.org/uniprot/P9WIH1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE family immunomodulator PE15 ^@ http://purl.uniprot.org/annotation/PRO_0000023572 http://togogenome.org/gene/83332:Rv2409c ^@ http://purl.uniprot.org/uniprot/P71734 ^@ Region ^@ Domain Extent ^@ TGc ^@ http://togogenome.org/gene/83332:Rv2926c ^@ http://purl.uniprot.org/uniprot/P9WL17 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2926c ^@ http://purl.uniprot.org/annotation/PRO_0000104106 http://togogenome.org/gene/83332:Rv1038c ^@ http://purl.uniprot.org/uniprot/P9WNJ9 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxJ ^@ http://purl.uniprot.org/annotation/PRO_0000167802 http://togogenome.org/gene/83332:Rv2975a ^@ http://purl.uniprot.org/uniprot/P0DV54 ^@ Molecule Processing ^@ Chain|||Initiator Methionine ^@ 50S ribosomal protein L28-3|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000455667 http://togogenome.org/gene/83332:Rv1872c ^@ http://purl.uniprot.org/uniprot/P9WND5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ FMN hydroxy acid dehydrogenase|||Proton acceptor|||Putative L-lactate dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000390893 http://togogenome.org/gene/83332:Rv0767c ^@ http://purl.uniprot.org/uniprot/P9WMD7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv0767c ^@ http://purl.uniprot.org/annotation/PRO_0000070659 http://togogenome.org/gene/83332:Rv1299 ^@ http://purl.uniprot.org/uniprot/P9WHG3 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||N5-methylglutamine|||Peptide chain release factor 1|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000177711 http://togogenome.org/gene/83332:Rv2526 ^@ http://purl.uniprot.org/uniprot/P9WJ49 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB17 ^@ http://purl.uniprot.org/annotation/PRO_0000408063 http://togogenome.org/gene/83332:Rv0595c ^@ http://purl.uniprot.org/uniprot/O07783 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ Does not inhibit growth, forms complex with VapB4.|||PINc|||Ribonuclease VapC4 ^@ http://purl.uniprot.org/annotation/PRO_0000407867 http://togogenome.org/gene/83332:Rv1440 ^@ http://purl.uniprot.org/uniprot/P9WGN5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable protein-export membrane protein SecG ^@ http://purl.uniprot.org/annotation/PRO_0000157235 http://togogenome.org/gene/83332:Rv0063 ^@ http://purl.uniprot.org/uniprot/O53608 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ FAD-binding PCMH-type ^@ http://purl.uniprot.org/annotation/PRO_5010339388 http://togogenome.org/gene/83332:Rv1271c ^@ http://purl.uniprot.org/uniprot/P9WM43 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1271c ^@ http://purl.uniprot.org/annotation/PRO_0000014091 http://togogenome.org/gene/83332:Rv2095c ^@ http://purl.uniprot.org/uniprot/P9WIL9 ^@ Molecule Processing ^@ Chain ^@ Protein PafC ^@ http://purl.uniprot.org/annotation/PRO_0000014122 http://togogenome.org/gene/83332:Rv1074c ^@ http://purl.uniprot.org/uniprot/O53422 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Acyl-thioester intermediate|||Proton acceptor|||Thiolase_C|||Thiolase_N ^@ http://togogenome.org/gene/83332:Rv3457c ^@ http://purl.uniprot.org/uniprot/P9WGZ1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ DNA-directed RNA polymerase subunit alpha ^@ http://purl.uniprot.org/annotation/PRO_0000175345 http://togogenome.org/gene/83332:Rv0171 ^@ http://purl.uniprot.org/uniprot/O07415 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Mce4_CUP1|||MlaD|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1558 ^@ http://purl.uniprot.org/uniprot/P9WP11 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Strand|||Turn ^@ F420H(2)-dependent quinone reductase Rv1558|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000103879 http://togogenome.org/gene/83332:Rv1928c ^@ http://purl.uniprot.org/uniprot/P95286 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv3091 ^@ http://purl.uniprot.org/uniprot/I6YB49 ^@ Region|||Site ^@ Active Site|||Domain Extent|||Motif ^@ DGA/G|||GXGXXG|||GXSXG|||Nucleophile|||PNPLA|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2217 ^@ http://purl.uniprot.org/uniprot/P9WK83 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand ^@ Acyl-thioester intermediate|||BPL/LPL catalytic|||Loss of activity.|||Octanoyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000062851 http://togogenome.org/gene/83332:Rv3423c ^@ http://purl.uniprot.org/uniprot/P9WQA9 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Alanine racemase|||N6-(pyridoxal phosphate)lysine|||Proton acceptor; specific for D-alanine|||Proton acceptor; specific for L-alanine ^@ http://purl.uniprot.org/annotation/PRO_0000114539 http://togogenome.org/gene/83332:Rv0290 ^@ http://purl.uniprot.org/uniprot/P9WNQ3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-3 secretion system protein EccD3|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393235 http://togogenome.org/gene/83332:Rv2044c ^@ http://purl.uniprot.org/uniprot/O53487 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3221c ^@ http://purl.uniprot.org/uniprot/P9WPQ1 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ Biotinyl-binding|||Biotinylated protein TB7.3|||N6-biotinyllysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000146838 http://togogenome.org/gene/83332:Rv0468 ^@ http://purl.uniprot.org/uniprot/P9WNP7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 3-hydroxybutyryl-CoA dehydrogenase|||Loss of fatty acyl dehydrogenase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000403378 http://togogenome.org/gene/83332:Rv3729 ^@ http://purl.uniprot.org/uniprot/O69696 ^@ Region ^@ Domain Extent ^@ Radical SAM core ^@ http://togogenome.org/gene/83332:Rv0113 ^@ http://purl.uniprot.org/uniprot/P9WGG1 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ 14.5-fold decrease in catalytic efficiency.|||24-fold decrease in catalytic efficiency.|||3.1-fold decrease in catalytic efficiency.|||3.5-fold decrease in catalytic efficiency.|||4.4-fold decrease in catalytic efficiency.|||6.6-fold decrease in catalytic efficiency.|||Phosphoheptose isomerase|||SIS ^@ http://purl.uniprot.org/annotation/PRO_0000136536 http://togogenome.org/gene/83332:Rv0961 ^@ http://purl.uniprot.org/uniprot/P9WKM9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0961 ^@ http://purl.uniprot.org/annotation/PRO_0000103757 http://togogenome.org/gene/83332:Rv0431 ^@ http://purl.uniprot.org/uniprot/P96277 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Helical|||LytR_C|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3040c ^@ http://purl.uniprot.org/uniprot/O53287 ^@ Region ^@ Domain Extent ^@ Nudix hydrolase ^@ http://togogenome.org/gene/83332:Rv3904c ^@ http://purl.uniprot.org/uniprot/P9WNH9 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxE ^@ http://purl.uniprot.org/annotation/PRO_0000167819 http://togogenome.org/gene/83332:Rv3553 ^@ http://purl.uniprot.org/uniprot/P71847 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000452307 http://togogenome.org/gene/83332:Rv0783c ^@ http://purl.uniprot.org/uniprot/P9WG89 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Multidrug resistance protein B homolog ^@ http://purl.uniprot.org/annotation/PRO_0000390687 http://togogenome.org/gene/83332:Rv0252 ^@ http://purl.uniprot.org/uniprot/O53674 ^@ Region ^@ Domain Extent ^@ Fer2_BFD|||NIR_SIR|||NIR_SIR_ferr|||Pyr_redox_2|||Rubredoxin_C ^@ http://togogenome.org/gene/83332:Rv2449c ^@ http://purl.uniprot.org/uniprot/O53176 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Crosslink|||Transmembrane ^@ Helical|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Putative trans-acting enoyl reductase Rv2449c ^@ http://purl.uniprot.org/annotation/PRO_0000396094 http://togogenome.org/gene/83332:Rv1085c ^@ http://purl.uniprot.org/uniprot/P9WFN7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||UPF0073 membrane protein Rv1085c ^@ http://purl.uniprot.org/annotation/PRO_0000176902 http://togogenome.org/gene/83332:Rv1445c ^@ http://purl.uniprot.org/uniprot/P9WQP5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ 6-phosphogluconolactonase ^@ http://purl.uniprot.org/annotation/PRO_0000090101 http://togogenome.org/gene/83332:Rv2625c ^@ http://purl.uniprot.org/uniprot/P9WHR1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ CBS 1|||CBS 2|||Helical|||Putative zinc metalloprotease Rip3 ^@ http://purl.uniprot.org/annotation/PRO_0000392914 http://togogenome.org/gene/83332:Rv2268c ^@ http://purl.uniprot.org/uniprot/P9WPN7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Transmembrane ^@ Helical|||Putative cytochrome P450 128|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052284 http://togogenome.org/gene/83332:Rv1411c ^@ http://purl.uniprot.org/uniprot/P9WK45 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Lipid Binding|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ Decreased TLR2 agonist activity, cannot acquire lipid from mycobacterial extracts, cavity entrance and size decrease. Binds PIM6, LM and ManLAM 10-100-fold less well than wild-type, binds de-acylated LM and ManLAM as well as wild-type. Decreased ability to transfer triacylglyceride between lipid bilayers.|||Lipoarabinomannan carrier protein LprG|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018146 http://togogenome.org/gene/83332:Rv3102c ^@ http://purl.uniprot.org/uniprot/O05779 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Sequence Conflict ^@ ABC transporter|||Cell division ATP-binding protein FtsE ^@ http://purl.uniprot.org/annotation/PRO_0000432514 http://togogenome.org/gene/83332:Rv0380c ^@ http://purl.uniprot.org/uniprot/O53715 ^@ Region ^@ Domain Extent ^@ SpoU_methylase ^@ http://togogenome.org/gene/83332:Rv2588c ^@ http://purl.uniprot.org/uniprot/P9WL75 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Sec translocon accessory complex subunit YajC ^@ http://purl.uniprot.org/annotation/PRO_0000014139 http://togogenome.org/gene/83332:Rv0904c ^@ http://purl.uniprot.org/uniprot/P9WQH9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ CoA carboxyltransferase C-terminal|||CoA carboxyltransferase N-terminal|||Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit ^@ http://purl.uniprot.org/annotation/PRO_0000199773 http://togogenome.org/gene/83332:Rv2084 ^@ http://purl.uniprot.org/uniprot/P9WLK1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic residues|||Uncharacterized protein Rv2084 ^@ http://purl.uniprot.org/annotation/PRO_0000103955 http://togogenome.org/gene/83332:Rv1793 ^@ http://purl.uniprot.org/uniprot/P9WNJ3 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxN ^@ http://purl.uniprot.org/annotation/PRO_0000167808 http://togogenome.org/gene/83332:Rv2936 ^@ http://purl.uniprot.org/uniprot/P9WQL9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Doxorubicin resistance ATP-binding protein DrrA ^@ http://purl.uniprot.org/annotation/PRO_0000393225 http://togogenome.org/gene/83332:Rv1471 ^@ http://purl.uniprot.org/uniprot/L7N664 ^@ Modification|||Region ^@ Disulfide Bond|||Domain Extent ^@ Redox-active|||Thioredoxin ^@ http://togogenome.org/gene/83332:Rv2419c ^@ http://purl.uniprot.org/uniprot/P9WIC7 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ About 5% of wild-type phosphatase activity.|||Almost completely abolished phosphatase activity.|||Disrupts dimerization of the enzyme, which exists as a monomer and has lost its ability to perform dephosphorylation.|||Glucosyl-3-phosphoglycerate phosphatase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Loss of phosphatase activity.|||Proton donor/acceptor|||Tele-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000396114 http://togogenome.org/gene/83332:Rv1051c ^@ http://purl.uniprot.org/uniprot/O53399 ^@ Region ^@ Domain Extent ^@ HTH_17 ^@ http://togogenome.org/gene/83332:Rv3077 ^@ http://purl.uniprot.org/uniprot/Q6MX15 ^@ Modification|||Region ^@ Domain Extent|||Modified Residue ^@ 3-oxoalanine (Cys)|||Sulfatase ^@ http://togogenome.org/gene/83332:Rv3232c ^@ http://purl.uniprot.org/uniprot/O05877 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Modified Residue|||Mutagenesis Site ^@ GDP-polyphosphate phosphotransferase|||Loss of GTP-synthesizing activity and lack of autophosphorylation. Does not interact with Ndk.|||Partial loss of GTP-synthesizing activity and decrease in autophosphorylation. Loss of GTP-synthesizing activity and lack of autophosphorylation; when associated with A-115.|||Partial loss of GTP-synthesizing activity and decrease in autophosphorylation. Loss of GTP-synthesizing activity and lack of autophosphorylation; when associated with A-247.|||Partial loss of GTP-synthesizing activity.|||Phosphohistidine|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000442586 http://togogenome.org/gene/83332:Rv0480c ^@ http://purl.uniprot.org/uniprot/P9WJ01 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ CN hydrolase|||Hydrolase Rv0480c|||Nucleophile|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000213261 http://togogenome.org/gene/83332:Rv1309 ^@ http://purl.uniprot.org/uniprot/P9WPU9 ^@ Molecule Processing ^@ Chain ^@ ATP synthase gamma chain ^@ http://purl.uniprot.org/annotation/PRO_0000073318 http://togogenome.org/gene/83332:Rv2887 ^@ http://purl.uniprot.org/uniprot/P9WME9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes binding to Rv0560c promoter.|||Attenuates the ability to bind salicylate.|||HTH marR-type|||HTH-type transcriptional repressor Rv2887 ^@ http://purl.uniprot.org/annotation/PRO_0000054410 http://togogenome.org/gene/83332:Rv3051c ^@ http://purl.uniprot.org/uniprot/P9WH75 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond|||Sequence Conflict ^@ Cysteine radical intermediate|||Proton acceptor|||Redox-active|||Ribonucleoside-diphosphate reductase subunit alpha ^@ http://purl.uniprot.org/annotation/PRO_0000187221 http://togogenome.org/gene/83332:Rv2537c ^@ http://purl.uniprot.org/uniprot/P9WPX7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Sequence Conflict|||Strand|||Turn ^@ 3-dehydroquinate dehydratase|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000159910 http://togogenome.org/gene/83332:Rv0266c ^@ http://purl.uniprot.org/uniprot/P95223 ^@ Region ^@ Domain Extent ^@ Hydant_A_N|||Hydantoinase_A|||Hydantoinase_B ^@ http://togogenome.org/gene/83332:Rv3200c ^@ http://purl.uniprot.org/uniprot/O53346 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||RCK N-terminal ^@ http://togogenome.org/gene/83332:Rv1969 ^@ http://purl.uniprot.org/uniprot/O53970 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Mce4_CUP1|||MlaD ^@ http://purl.uniprot.org/annotation/PRO_5010295866 http://togogenome.org/gene/83332:Rv0073 ^@ http://purl.uniprot.org/uniprot/P9WQK5 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Crosslink|||Domain Extent ^@ ABC transporter|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Uncharacterized ABC transporter ATP-binding protein Rv0073 ^@ http://purl.uniprot.org/annotation/PRO_0000395860 http://togogenome.org/gene/83332:Rv1281c ^@ http://purl.uniprot.org/uniprot/P9WQJ5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter 1|||ABC transporter 2|||Uncharacterized ABC transporter ATP-binding protein Rv1281c ^@ http://purl.uniprot.org/annotation/PRO_0000093259 http://togogenome.org/gene/83332:Rv2111c ^@ http://purl.uniprot.org/uniprot/P9WHN5 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Coiled-Coil|||Compositionally Biased Region|||Crosslink|||Helix|||Modified Residue ^@ Basic and acidic residues|||Deamidated glutamine; alternate|||Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins); alternate|||Prokaryotic ubiquitin-like protein Pup ^@ http://purl.uniprot.org/annotation/PRO_0000383476 http://togogenome.org/gene/83332:Rv0737 ^@ http://purl.uniprot.org/uniprot/I6Y8K3 ^@ Region ^@ Domain Extent ^@ HTH marR-type ^@ http://togogenome.org/gene/83332:Rv3871 ^@ http://purl.uniprot.org/uniprot/P9WNB1 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Cells unable to export EsxB.|||ESX-1 secretion system protein EccCb1|||FtsK 1|||FtsK 2 ^@ http://purl.uniprot.org/annotation/PRO_0000393429 http://togogenome.org/gene/83332:Rv0393 ^@ http://purl.uniprot.org/uniprot/P95201 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ HNHc|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1938 ^@ http://purl.uniprot.org/uniprot/I6YC03 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ AB hydrolase-1|||Epoxide hydrolase B|||Nucleophile|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000438586 http://togogenome.org/gene/83332:Rv0569 ^@ http://purl.uniprot.org/uniprot/P9WM83 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0569 ^@ http://purl.uniprot.org/annotation/PRO_0000392682 http://togogenome.org/gene/83332:Rv1401 ^@ http://purl.uniprot.org/uniprot/P9WG51 ^@ Molecule Processing|||Region ^@ Chain|||Initiator Methionine|||Transmembrane ^@ Helical|||Lysoplasmalogenase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000201848 http://togogenome.org/gene/83332:Rv3125c ^@ http://purl.uniprot.org/uniprot/P9WHY5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE49 ^@ http://purl.uniprot.org/annotation/PRO_0000378483 http://togogenome.org/gene/83332:Rv2227 ^@ http://purl.uniprot.org/uniprot/P9WLH7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2227 ^@ http://purl.uniprot.org/annotation/PRO_0000103980 http://togogenome.org/gene/83332:Rv1623c ^@ http://purl.uniprot.org/uniprot/L7N662 ^@ Modification|||Region ^@ Disulfide Bond|||Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0302 ^@ http://purl.uniprot.org/uniprot/O07229 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2054 ^@ http://purl.uniprot.org/uniprot/O86353 ^@ Region ^@ Domain Extent ^@ DLH ^@ http://togogenome.org/gene/83332:Rv2898c ^@ http://purl.uniprot.org/uniprot/P9WFM9 ^@ Molecule Processing ^@ Chain ^@ UPF0102 protein Rv2898c ^@ http://purl.uniprot.org/annotation/PRO_0000167363 http://togogenome.org/gene/83332:Rv3775 ^@ http://purl.uniprot.org/uniprot/P72041 ^@ Region ^@ Domain Extent ^@ Beta-lactamase ^@ http://togogenome.org/gene/83332:Rv2724c ^@ http://purl.uniprot.org/uniprot/O33229 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv3564 ^@ http://purl.uniprot.org/uniprot/I6YCF5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Acyl-CoA dehydrogenase IpdE2 ^@ http://purl.uniprot.org/annotation/PRO_0000452317 http://togogenome.org/gene/83332:Rv0793 ^@ http://purl.uniprot.org/uniprot/O86332 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand ^@ ABM|||Putative monooxygenase Rv0793 ^@ http://purl.uniprot.org/annotation/PRO_0000420880 http://togogenome.org/gene/83332:Rv2615c ^@ http://purl.uniprot.org/uniprot/Q79FC3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5004287722 http://togogenome.org/gene/83332:Rv1627c ^@ http://purl.uniprot.org/uniprot/O06144 ^@ Region ^@ Domain Extent ^@ Thiolase_N ^@ http://togogenome.org/gene/83332:Rv1101c ^@ http://purl.uniprot.org/uniprot/P9WFM3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative transport protein Rv1101c ^@ http://purl.uniprot.org/annotation/PRO_0000148318 http://togogenome.org/gene/83332:Rv1457c ^@ http://purl.uniprot.org/uniprot/O86349 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC2_membrane|||Helical ^@ http://togogenome.org/gene/83332:Rv2636 ^@ http://purl.uniprot.org/uniprot/P9WL55 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative O-phosphotransferase Rv2636 ^@ http://purl.uniprot.org/annotation/PRO_0000104076 http://togogenome.org/gene/83332:Rv2281 ^@ http://purl.uniprot.org/uniprot/P9WIA5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative phosphate permease Rv2281 ^@ http://purl.uniprot.org/annotation/PRO_0000080801 http://togogenome.org/gene/83332:Rv3117 ^@ http://purl.uniprot.org/uniprot/P9WHF9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Cysteine persulfide intermediate|||Putative thiosulfate sulfurtransferase|||Rhodanese 1|||Rhodanese 2 ^@ http://purl.uniprot.org/annotation/PRO_0000139415 http://togogenome.org/gene/83332:Rv0914c ^@ http://purl.uniprot.org/uniprot/I6XWJ8 ^@ Region ^@ Domain Extent ^@ Thiolase_C|||Thiolase_N ^@ http://togogenome.org/gene/83332:Rv1844c ^@ http://purl.uniprot.org/uniprot/Q79FJ2 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ 6PGD|||Proton acceptor|||Proton donor|||in other chain ^@ http://togogenome.org/gene/83332:Rv1741 ^@ http://purl.uniprot.org/uniprot/P9WF71 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative ribonuclease VapC34 ^@ http://purl.uniprot.org/annotation/PRO_0000413609 http://togogenome.org/gene/83332:Rv2946c ^@ http://purl.uniprot.org/uniprot/P96285 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Modified Residue ^@ Carrier|||For acyltransferase activity|||O-(pantetheine 4'-phosphoryl)serine|||Polar residues|||Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 ^@ http://purl.uniprot.org/annotation/PRO_0000406600 http://togogenome.org/gene/83332:Rv1064c ^@ http://purl.uniprot.org/uniprot/P9WK57 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LpqV|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018133 http://togogenome.org/gene/83332:Rv3798 ^@ http://purl.uniprot.org/uniprot/P9WKH7 ^@ Molecule Processing ^@ Chain ^@ Transposase for insertion sequence element IS1557 ^@ http://purl.uniprot.org/annotation/PRO_0000075450 http://togogenome.org/gene/83332:Rv2754c ^@ http://purl.uniprot.org/uniprot/P9WG57 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Motif|||Mutagenesis Site|||Strand|||Turn ^@ Flavin-dependent thymidylate synthase|||Involved in ionization of N3 of dUMP, leading to its activation|||Loss of catalytic activity since it is not able to complement an E.coli thyA deletion mutant.|||Still able to complement an E.coli thyA deletion mutant.|||ThyX|||ThyX motif|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000175570 http://togogenome.org/gene/83332:Rv3245c ^@ http://purl.uniprot.org/uniprot/P9WGK9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Sequence Conflict|||Transmembrane ^@ Basic and acidic residues|||Basic residues|||HAMP|||Helical|||Histidine kinase|||Loss of autophosphorylation. Partially complements an M.smegmatis mtrB disruption, cells are still filamentous and bulged but the protein targets to septa.|||Phosphohistidine; by autocatalysis|||Pro residues|||Sensor histidine kinase MtrB ^@ http://purl.uniprot.org/annotation/PRO_0000074809 http://togogenome.org/gene/83332:Rv0491 ^@ http://purl.uniprot.org/uniprot/P9WGL9 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Modified Residue|||Strand|||Turn ^@ 4-aspartylphosphate|||OmpR/PhoB-type|||Response regulatory|||Sensory transduction protein RegX3 ^@ http://purl.uniprot.org/annotation/PRO_0000081334 http://togogenome.org/gene/83332:Rv3628 ^@ http://purl.uniprot.org/uniprot/P9WI55 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 3-fold decrease in catalytic activity, and 2-fold decrease in substrate affinity.|||4-fold decrease in catalytic activity with Mg(2+) as cofactor. 3-fold increase in catalytic activity with Zn(2+) as cofactor. Shifts the pH for optimal activity to 8.5.|||Inorganic pyrophosphatase|||Loss of catalytic activity.|||Nearly no effect on catalytic activity with Mg(2+) as cofactor. 10-fold increase in catalytic activity with Zn(2+) as cofactor.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000137512 http://togogenome.org/gene/83332:Rv1712 ^@ http://purl.uniprot.org/uniprot/P9WPA9 ^@ Experimental Information|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Mass ^@ Cytidylate kinase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000131943 http://togogenome.org/gene/83332:Rv2582 ^@ http://purl.uniprot.org/uniprot/P9WHW1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ PPIase cyclophilin-type|||Polar residues|||Probable peptidyl-prolyl cis-trans isomerase B ^@ http://purl.uniprot.org/annotation/PRO_0000064212 http://togogenome.org/gene/83332:Rv0135c ^@ http://purl.uniprot.org/uniprot/P96812 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2547 ^@ http://purl.uniprot.org/uniprot/P95006 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB19 ^@ http://purl.uniprot.org/annotation/PRO_0000408065 http://togogenome.org/gene/83332:Rv3061c ^@ http://purl.uniprot.org/uniprot/I6X654 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv3211 ^@ http://purl.uniprot.org/uniprot/O05855 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Motif ^@ Basic and acidic residues|||Helicase ATP-binding|||Helicase C-terminal|||Polar residues|||Q motif|||Q_MOTIF ^@ http://togogenome.org/gene/83332:Rv1979c ^@ http://purl.uniprot.org/uniprot/P9WQM5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized transporter Rv1979c ^@ http://purl.uniprot.org/annotation/PRO_0000054225 http://togogenome.org/gene/83332:Rv0083 ^@ http://purl.uniprot.org/uniprot/P9WIW3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0083 ^@ http://purl.uniprot.org/annotation/PRO_0000118049 http://togogenome.org/gene/83332:Rv0941c ^@ http://purl.uniprot.org/uniprot/P71568 ^@ Region ^@ Domain Extent ^@ STAS ^@ http://togogenome.org/gene/83332:Rv0435c ^@ http://purl.uniprot.org/uniprot/P96281 ^@ Region ^@ Domain Extent ^@ AAA|||CDC48_N ^@ http://togogenome.org/gene/83332:Rv2121c ^@ http://purl.uniprot.org/uniprot/P9WMN1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ ATP phosphoribosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000151857 http://togogenome.org/gene/83332:Rv2646 ^@ http://purl.uniprot.org/uniprot/I6XEU5 ^@ Region ^@ Domain Extent ^@ Core-binding (CB)|||Tyr recombinase ^@ http://togogenome.org/gene/83332:Rv1616 ^@ http://purl.uniprot.org/uniprot/O06133 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0751c ^@ http://purl.uniprot.org/uniprot/P9WNY5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Probable 3-hydroxyisobutyrate dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000173056 http://togogenome.org/gene/83332:Rv3884c ^@ http://purl.uniprot.org/uniprot/P9WPH7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ ESX-2 secretion system protein EccA2 ^@ http://purl.uniprot.org/annotation/PRO_0000063051 http://togogenome.org/gene/83332:Rv0403c ^@ http://purl.uniprot.org/uniprot/P9WJT5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport accessory protein MmpS1 ^@ http://purl.uniprot.org/annotation/PRO_0000216151 http://togogenome.org/gene/83332:Rv1583c ^@ http://purl.uniprot.org/uniprot/P9WLU1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1583c ^@ http://purl.uniprot.org/annotation/PRO_0000103885 http://togogenome.org/gene/83332:Rv3197A ^@ http://purl.uniprot.org/uniprot/Q6MX01 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||DNA Binding|||Domain Extent|||Helix|||Mass|||Strand|||Turn ^@ 4Fe-4S Wbl-type|||A.T hook|||Fully oxidized recombinant protein tagged at both termini.|||Fully reduced recombinant protein tagged at both termini.|||Probable transcriptional regulator WhiB7 ^@ http://purl.uniprot.org/annotation/PRO_0000420387 http://togogenome.org/gene/83332:Rv2765 ^@ http://purl.uniprot.org/uniprot/I6XF92 ^@ Region ^@ Domain Extent ^@ DLH ^@ http://togogenome.org/gene/83332:Rv2238c ^@ http://purl.uniprot.org/uniprot/P9WIE3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Alkyl hydroperoxide reductase E|||Cysteine sulfenic acid (-SOH) intermediate|||Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000135148 http://togogenome.org/gene/83332:Rv1759c ^@ http://purl.uniprot.org/uniprot/P9WIG5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||WAG22 antigen ^@ http://purl.uniprot.org/annotation/PRO_0000023574 http://togogenome.org/gene/83332:Rv2593c ^@ http://purl.uniprot.org/uniprot/P9WGW3 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Holliday junction ATP-dependent DNA helicase RuvA ^@ http://purl.uniprot.org/annotation/PRO_0000094653 http://togogenome.org/gene/83332:Rv2066 ^@ http://purl.uniprot.org/uniprot/P9WGB3 ^@ Molecule Processing ^@ Chain ^@ Cobalamin biosynthesis protein CobIJ ^@ http://purl.uniprot.org/annotation/PRO_0000150390 http://togogenome.org/gene/83332:Rv3787c ^@ http://purl.uniprot.org/uniprot/P9WFH3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3787c ^@ http://purl.uniprot.org/annotation/PRO_0000361241 http://togogenome.org/gene/83332:Rv2908c ^@ http://purl.uniprot.org/uniprot/P9WFM7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Initiator Methionine ^@ KH|||RNA-binding protein KhpA|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000163231 http://togogenome.org/gene/83332:Rv2557 ^@ http://purl.uniprot.org/uniprot/P9WLA5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2557 ^@ http://purl.uniprot.org/annotation/PRO_0000104035 http://togogenome.org/gene/83332:Rv0984 ^@ http://purl.uniprot.org/uniprot/O53897 ^@ Region ^@ Domain Extent ^@ MoCF_biosynth ^@ http://togogenome.org/gene/83332:Rv2734 ^@ http://purl.uniprot.org/uniprot/I6YA42 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv3575c ^@ http://purl.uniprot.org/uniprot/P96857 ^@ Region ^@ Domain Extent ^@ HTH lacI-type ^@ http://togogenome.org/gene/83332:Rv0806c ^@ http://purl.uniprot.org/uniprot/P9WGD1 ^@ Molecule Processing ^@ Chain ^@ Exopolysaccharide phosphotransferase CpsY ^@ http://purl.uniprot.org/annotation/PRO_0000235949 http://togogenome.org/gene/83332:Rv3582c ^@ http://purl.uniprot.org/uniprot/P9WKG9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000075592 http://togogenome.org/gene/83332:Rv2766c ^@ http://purl.uniprot.org/uniprot/I6YEB6 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv1637c ^@ http://purl.uniprot.org/uniprot/O06154 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv0271c ^@ http://purl.uniprot.org/uniprot/P95228 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv3400 ^@ http://purl.uniprot.org/uniprot/P9WKZ7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3400 ^@ http://purl.uniprot.org/annotation/PRO_0000104119 http://togogenome.org/gene/83332:Rv1114 ^@ http://purl.uniprot.org/uniprot/P9WF73 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC32 ^@ http://purl.uniprot.org/annotation/PRO_0000407889 http://togogenome.org/gene/83332:Rv1467c ^@ http://purl.uniprot.org/uniprot/O53158 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_C|||Acyl-CoA_dh_M|||AcylCoA_DH_N ^@ http://togogenome.org/gene/83332:Rv2854 ^@ http://purl.uniprot.org/uniprot/O05805 ^@ Region ^@ Domain Extent ^@ Hydrolase_4 ^@ http://togogenome.org/gene/83332:Rv1960c ^@ http://purl.uniprot.org/uniprot/P9WIJ7 ^@ Molecule Processing|||Region ^@ Chain|||Coiled-Coil ^@ Antitoxin ParD1 ^@ http://purl.uniprot.org/annotation/PRO_0000216353 http://togogenome.org/gene/83332:Rv0927c ^@ http://purl.uniprot.org/uniprot/P9WGQ5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv0927c ^@ http://purl.uniprot.org/annotation/PRO_0000415507 http://togogenome.org/gene/83332:Rv1991A ^@ http://purl.uniprot.org/uniprot/P9WJ87 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ Antitoxin MazE6|||No DNA-binding. ^@ http://purl.uniprot.org/annotation/PRO_0000406300 http://togogenome.org/gene/83332:Rv1751 ^@ http://purl.uniprot.org/uniprot/O65936 ^@ Region ^@ Domain Extent ^@ FAD_binding_3 ^@ http://togogenome.org/gene/83332:Rv2956 ^@ http://purl.uniprot.org/uniprot/I6Y242 ^@ Region ^@ Domain Extent ^@ Methyltransf_21 ^@ http://togogenome.org/gene/83332:Rv3809c ^@ http://purl.uniprot.org/uniprot/P9WIQ1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ UDP-galactopyranose mutase ^@ http://purl.uniprot.org/annotation/PRO_0000420735 http://togogenome.org/gene/83332:Rv1587c ^@ http://purl.uniprot.org/uniprot/O06603 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic residues|||HNHc ^@ http://togogenome.org/gene/83332:Rv2436 ^@ http://purl.uniprot.org/uniprot/P71913 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ PfkB|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv3255c ^@ http://purl.uniprot.org/uniprot/O05898 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ PMI_typeI_cat ^@ http://togogenome.org/gene/83332:Rv0501 ^@ http://purl.uniprot.org/uniprot/P9WKT3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0501 ^@ http://purl.uniprot.org/annotation/PRO_0000103707 http://togogenome.org/gene/83332:Rv1723 ^@ http://purl.uniprot.org/uniprot/P71981 ^@ Region ^@ Domain Extent ^@ Beta-lactamase ^@ http://togogenome.org/gene/83332:Rv2252 ^@ http://purl.uniprot.org/uniprot/P9WP29 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ DAGKc|||Diacylglycerol kinase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000386484 http://togogenome.org/gene/83332:Rv3442c ^@ http://purl.uniprot.org/uniprot/P9WH25 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue ^@ 30S ribosomal protein S9|||Basic and acidic residues|||Basic residues|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000111379 http://togogenome.org/gene/83332:Rv3072c ^@ http://purl.uniprot.org/uniprot/P95086 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Bac_luciferase|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1174c ^@ http://purl.uniprot.org/uniprot/O50430 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010161307 http://togogenome.org/gene/83332:Rv1991c ^@ http://purl.uniprot.org/uniprot/P9WII3 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Endoribonuclease MazF6 ^@ http://purl.uniprot.org/annotation/PRO_0000201904 http://togogenome.org/gene/83332:Rv0624 ^@ http://purl.uniprot.org/uniprot/P9WF77 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ PINc|||Ribonuclease VapC30 ^@ http://purl.uniprot.org/annotation/PRO_0000221199 http://togogenome.org/gene/83332:Rv0093c ^@ http://purl.uniprot.org/uniprot/P9WM69 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0093c ^@ http://purl.uniprot.org/annotation/PRO_0000103666 http://togogenome.org/gene/83332:Rv3757c ^@ http://purl.uniprot.org/uniprot/O69723 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv0953c ^@ http://purl.uniprot.org/uniprot/P9WKN5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0953c ^@ http://purl.uniprot.org/annotation/PRO_0000103749 http://togogenome.org/gene/83332:Rv0447c ^@ http://purl.uniprot.org/uniprot/O53732 ^@ Molecule Processing ^@ Chain ^@ Tuberculostearic acid methyltransferase UfaA1 ^@ http://purl.uniprot.org/annotation/PRO_0000432977 http://togogenome.org/gene/83332:Rv2658c ^@ http://purl.uniprot.org/uniprot/P9WL47 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2658c ^@ http://purl.uniprot.org/annotation/PRO_0000104082 http://togogenome.org/gene/83332:Rv0764c ^@ http://purl.uniprot.org/uniprot/P9WPP9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Sterol 14alpha-demethylase|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052017 http://togogenome.org/gene/83332:Rv2123 ^@ http://purl.uniprot.org/uniprot/Q79FH3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE37 ^@ http://purl.uniprot.org/annotation/PRO_0000379114 http://togogenome.org/gene/83332:Rv1286 ^@ http://purl.uniprot.org/uniprot/P9WNM5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Bifunctional enzyme CysN/CysC|||Phosphoserine intermediate|||tr-type G ^@ http://purl.uniprot.org/annotation/PRO_0000091537 http://togogenome.org/gene/83332:Rv0592 ^@ http://purl.uniprot.org/uniprot/I6WYT7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ Mce4_CUP1|||MlaD|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5010175671 http://togogenome.org/gene/83332:Rv3313c ^@ http://purl.uniprot.org/uniprot/P63907 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Adenosine deaminase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000194374 http://togogenome.org/gene/83332:Rv2286c ^@ http://purl.uniprot.org/uniprot/P9WLE7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2286c ^@ http://purl.uniprot.org/annotation/PRO_0000104006 http://togogenome.org/gene/83332:Rv3264c ^@ http://purl.uniprot.org/uniprot/L7N6A5 ^@ Molecule Processing ^@ Chain ^@ Mannose-1-phosphate guanylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000456573 http://togogenome.org/gene/83332:Rv1426c ^@ http://purl.uniprot.org/uniprot/O06832 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1076 ^@ http://purl.uniprot.org/uniprot/O53424 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ 20% loss of activity.|||85% loss of activity.|||Complete loss of activity.|||Esterase LipU ^@ http://purl.uniprot.org/annotation/PRO_0000448882 http://togogenome.org/gene/83332:Rv2779c ^@ http://purl.uniprot.org/uniprot/O33321 ^@ Region ^@ Domain Extent ^@ HTH asnC-type ^@ http://togogenome.org/gene/83332:Rv2248 ^@ http://purl.uniprot.org/uniprot/P9WLG5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2248 ^@ http://purl.uniprot.org/annotation/PRO_0000103990 http://togogenome.org/gene/83332:Rv1258c ^@ http://purl.uniprot.org/uniprot/P9WJX9 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Mutagenesis Site|||Transmembrane ^@ Helical|||Multidrug efflux pump Tap|||Shows higher efflux activity. Causes clinically relevant high-level drug resistance to pyrazinamide (PZA), isoniazid (INH) and streptomycin (SM).|||Shows higher efflux activity. Causes clinically relevant low-level drug resistance to pyrazinamide (PZA), isoniazid (INH) and streptomycin (SM). ^@ http://purl.uniprot.org/annotation/PRO_0000103772 http://togogenome.org/gene/83332:Rv1801 ^@ http://purl.uniprot.org/uniprot/P9WI09 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE29 ^@ http://purl.uniprot.org/annotation/PRO_0000378481 http://togogenome.org/gene/83332:Rv2076c ^@ http://purl.uniprot.org/uniprot/P9WLL3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2076c ^@ http://purl.uniprot.org/annotation/PRO_0000103947 http://togogenome.org/gene/83332:Rv2604c ^@ http://purl.uniprot.org/uniprot/P9WII7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Charge relay system|||Nucleophile|||Pyridoxal 5'-phosphate synthase subunit PdxT ^@ http://purl.uniprot.org/annotation/PRO_0000135649 http://togogenome.org/gene/83332:Rv1733c ^@ http://purl.uniprot.org/uniprot/P9WLS9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable membrane protein Rv1733c ^@ http://purl.uniprot.org/annotation/PRO_0000392906 http://togogenome.org/gene/83332:Rv2919c ^@ http://purl.uniprot.org/uniprot/P9WN31 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Nitrogen regulatory protein P-II|||O-UMP-tyrosine ^@ http://purl.uniprot.org/annotation/PRO_0000139779 http://togogenome.org/gene/83332:Rv0707 ^@ http://purl.uniprot.org/uniprot/P9WH37 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ 30S ribosomal protein S3|||KH type-2 ^@ http://purl.uniprot.org/annotation/PRO_0000130158 http://togogenome.org/gene/83332:Rv0165c ^@ http://purl.uniprot.org/uniprot/Q79G00 ^@ Region ^@ Domain Extent ^@ HTH gntR-type ^@ http://togogenome.org/gene/83332:Rv2746c ^@ http://purl.uniprot.org/uniprot/P9WPG3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable phosphatidylglycerophosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000393110 http://togogenome.org/gene/83332:Rv0140 ^@ http://purl.uniprot.org/uniprot/P96817 ^@ Region ^@ Domain Extent ^@ NTP_transf_9 ^@ http://togogenome.org/gene/83332:Rv3593 ^@ http://purl.uniprot.org/uniprot/O06155 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Beta-lactamase2|||ORF_12_N ^@ http://purl.uniprot.org/annotation/PRO_5010295863 http://togogenome.org/gene/83332:Rv2861c ^@ http://purl.uniprot.org/uniprot/P9WK19 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mass|||Strand|||Turn ^@ Methionine aminopeptidase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000148948 http://togogenome.org/gene/83332:Rv0104 ^@ http://purl.uniprot.org/uniprot/P9WM61 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0104 ^@ http://purl.uniprot.org/annotation/PRO_0000103675 http://togogenome.org/gene/83332:Rv3223c ^@ http://purl.uniprot.org/uniprot/P9WGH9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif|||Mutagenesis Site|||Strand|||Turn ^@ ECF RNA polymerase sigma factor SigH|||H-T-H motif|||No in vitro phosphorylation by PknB; when associated with A-106.|||No in vitro phosphorylation by PknB; when associated with A-26.|||Polymerase core binding ^@ http://purl.uniprot.org/annotation/PRO_0000094004 http://togogenome.org/gene/83332:Rv0472c ^@ http://purl.uniprot.org/uniprot/P9WMD9 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv0472c ^@ http://purl.uniprot.org/annotation/PRO_0000382633 http://togogenome.org/gene/83332:Rv1648 ^@ http://purl.uniprot.org/uniprot/P94983 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical ^@ http://purl.uniprot.org/annotation/PRO_5010332138 http://togogenome.org/gene/83332:Rv0287 ^@ http://purl.uniprot.org/uniprot/O53692 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ ESAT-6-like protein EsxG|||N-acetylserine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000434997 http://togogenome.org/gene/83332:Rv3410c ^@ http://purl.uniprot.org/uniprot/P9WKI5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized oxidoreductase Rv3410c ^@ http://purl.uniprot.org/annotation/PRO_0000093782 http://togogenome.org/gene/83332:Rv1125 ^@ http://purl.uniprot.org/uniprot/O06577 ^@ Region ^@ Domain Extent ^@ WS_DGAT_C ^@ http://togogenome.org/gene/83332:Rv1480 ^@ http://purl.uniprot.org/uniprot/P9WLX5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1480 ^@ http://purl.uniprot.org/annotation/PRO_0000103849 http://togogenome.org/gene/83332:Rv2866 ^@ http://purl.uniprot.org/uniprot/O33348 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Toxin RelG ^@ http://purl.uniprot.org/annotation/PRO_0000406200 http://togogenome.org/gene/83332:Rv0110 ^@ http://purl.uniprot.org/uniprot/O53632 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Rhomboid ^@ http://togogenome.org/gene/83332:Rv2296 ^@ http://purl.uniprot.org/uniprot/P9WMS3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ AB hydrolase-1|||Haloalkane dehalogenase 1|||Nucleophile|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000216767 http://togogenome.org/gene/83332:Rv1769 ^@ http://purl.uniprot.org/uniprot/O06802 ^@ Region ^@ Domain Extent ^@ Ala_racemase_N ^@ http://togogenome.org/gene/83332:Rv2259 ^@ http://purl.uniprot.org/uniprot/O53533 ^@ Region ^@ Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv3822 ^@ http://purl.uniprot.org/uniprot/O07801 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Helical|||Lack of activity.|||PE-PPE|||Periplasmic|||SL1278 acyltransferase Chp1 ^@ http://purl.uniprot.org/annotation/PRO_0000432823 http://togogenome.org/gene/83332:Rv1597 ^@ http://purl.uniprot.org/uniprot/O06593 ^@ Region ^@ Domain Extent ^@ Methyltransf_11 ^@ http://togogenome.org/gene/83332:Rv2446c ^@ http://purl.uniprot.org/uniprot/O53173 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2086 ^@ http://purl.uniprot.org/uniprot/P64937 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2086 ^@ http://purl.uniprot.org/annotation/PRO_0000103958 http://togogenome.org/gene/83332:Rv3267 ^@ http://purl.uniprot.org/uniprot/P96872 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ LytR_C|||LytR_cpsA_psr ^@ http://purl.uniprot.org/annotation/PRO_5004161732 http://togogenome.org/gene/83332:Rv0513 ^@ http://purl.uniprot.org/uniprot/O33358 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3651 ^@ http://purl.uniprot.org/uniprot/I6YCP0 ^@ Region ^@ Domain Extent ^@ DUF5593|||DUF5628 ^@ http://togogenome.org/gene/83332:Rv0278c ^@ http://purl.uniprot.org/uniprot/P9WIG3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic residues|||PE|||Uncharacterized PE-PGRS family protein PE_PGRS3 ^@ http://purl.uniprot.org/annotation/PRO_0000023575 http://togogenome.org/gene/83332:Rv2265 ^@ http://purl.uniprot.org/uniprot/P9WLG3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2265 ^@ http://purl.uniprot.org/annotation/PRO_0000103991 http://togogenome.org/gene/83332:Rv3083 ^@ http://purl.uniprot.org/uniprot/P9WNF7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative FAD-containing monooxygenase MymA ^@ http://purl.uniprot.org/annotation/PRO_0000420876 http://togogenome.org/gene/83332:Rv3098A ^@ http://purl.uniprot.org/uniprot/V5QRX7 ^@ Molecule Processing ^@ Chain ^@ Putative toxin Rv3098A/RVBD_3098A ^@ http://purl.uniprot.org/annotation/PRO_0000431255 http://togogenome.org/gene/83332:Rv3088 ^@ http://purl.uniprot.org/uniprot/P9WKC3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Probable diacyglycerol O-acyltransferase Tgs4|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000222914 http://togogenome.org/gene/83332:Rv1184c ^@ http://purl.uniprot.org/uniprot/O50440 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Mutagenesis Site|||Transmembrane ^@ Diacyltrehalose acyltransferase Chp2|||Helical|||Lack of activity.|||PE-PPE ^@ http://purl.uniprot.org/annotation/PRO_0000432824 http://togogenome.org/gene/83332:Rv2564 ^@ http://purl.uniprot.org/uniprot/P9WQI5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ABC transporter|||Uncharacterized ABC transporter ATP-binding protein Rv2564 ^@ http://purl.uniprot.org/annotation/PRO_0000093268 http://togogenome.org/gene/83332:Rv0062 ^@ http://purl.uniprot.org/uniprot/Q79G13 ^@ Modification|||Region|||Site ^@ Active Site|||Binding Site|||Disulfide Bond|||Transmembrane ^@ Helical|||Proton acceptor|||Proton donor ^@ http://togogenome.org/gene/83332:Rv0634c ^@ http://purl.uniprot.org/uniprot/I6Y4A5 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv3767c ^@ http://purl.uniprot.org/uniprot/P9WFH5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3767c ^@ http://purl.uniprot.org/annotation/PRO_0000361240 http://togogenome.org/gene/83332:Rv1491c ^@ http://purl.uniprot.org/uniprot/P9WFS3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||TVP38/TMEM64 family membrane protein Rv1491c ^@ http://purl.uniprot.org/annotation/PRO_0000198638 http://togogenome.org/gene/83332:Rv1296 ^@ http://purl.uniprot.org/uniprot/P9WKE7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Homoserine kinase ^@ http://purl.uniprot.org/annotation/PRO_0000156590 http://togogenome.org/gene/83332:Rv2237A ^@ http://purl.uniprot.org/uniprot/I6XDU8 ^@ Region ^@ Coiled-Coil ^@ ^@ http://togogenome.org/gene/83332:Rv0249c ^@ http://purl.uniprot.org/uniprot/O53671 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1129c ^@ http://purl.uniprot.org/uniprot/O06581 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand|||Turn ^@ H-T-H motif|||HTH cro/C1-type|||HTH-type transcriptional regulator PrpR ^@ http://purl.uniprot.org/annotation/PRO_0000433054 http://togogenome.org/gene/83332:Rv3327 ^@ http://purl.uniprot.org/uniprot/O53377 ^@ Region ^@ Domain Extent ^@ DEDD_Tnp_IS110 ^@ http://togogenome.org/gene/83332:Rv1965 ^@ http://purl.uniprot.org/uniprot/O53966 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1437 ^@ http://purl.uniprot.org/uniprot/P9WID1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Phosphoglycerate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000145973 http://togogenome.org/gene/83332:Rv1092c ^@ http://purl.uniprot.org/uniprot/P9WPA7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Pantothenate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000194439 http://togogenome.org/gene/83332:Rv2789c ^@ http://purl.uniprot.org/uniprot/I6XFA9 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv1268c ^@ http://purl.uniprot.org/uniprot/P9WM47 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1268c ^@ http://purl.uniprot.org/annotation/PRO_0000014087 http://togogenome.org/gene/83332:Rv1917c ^@ http://purl.uniprot.org/uniprot/Q79FI9 ^@ Molecule Processing ^@ Chain ^@ PPE family protein PPE34 ^@ http://purl.uniprot.org/annotation/PRO_0000437939 http://togogenome.org/gene/83332:Rv2961 ^@ http://purl.uniprot.org/uniprot/P95131 ^@ Region ^@ Domain Extent ^@ DDE_Tnp_1 ^@ http://togogenome.org/gene/83332:Rv2617c ^@ http://purl.uniprot.org/uniprot/I6XER9 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1743 ^@ http://purl.uniprot.org/uniprot/P9WI77 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Cytoplasmic|||Extracellular|||Helical|||Lack of kinase activity.|||Phosphoserine; by autocatalysis|||Phosphothreonine; by autocatalysis|||Pro residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknE ^@ http://purl.uniprot.org/annotation/PRO_0000171211 http://togogenome.org/gene/83332:Rv2929 ^@ http://purl.uniprot.org/uniprot/P9WL13 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2929 ^@ http://purl.uniprot.org/annotation/PRO_0000014149 http://togogenome.org/gene/83332:Rv3452 ^@ http://purl.uniprot.org/uniprot/O06319 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Signal Peptide ^@ Nucleophile|||Phospholipase Culp4|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_5010306774 http://togogenome.org/gene/83332:Rv0656c ^@ http://purl.uniprot.org/uniprot/P9WFB5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC6 ^@ http://purl.uniprot.org/annotation/PRO_0000407869 http://togogenome.org/gene/83332:Rv3271c ^@ http://purl.uniprot.org/uniprot/P96876 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3606c ^@ http://purl.uniprot.org/uniprot/P9WNC7 ^@ Molecule Processing ^@ Chain ^@ 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ^@ http://purl.uniprot.org/annotation/PRO_0000168255 http://togogenome.org/gene/83332:Rv2996c ^@ http://purl.uniprot.org/uniprot/P9WNX3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ ACT|||D-3-phosphoglycerate dehydrogenase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000076005 http://togogenome.org/gene/83332:Rv0482 ^@ http://purl.uniprot.org/uniprot/B5AFK3|||http://purl.uniprot.org/uniprot/P9WJL9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ FAD-binding PCMH-type|||Proton donor|||UDP-N-acetylenolpyruvoylglucosamine reductase ^@ http://purl.uniprot.org/annotation/PRO_0000179230 http://togogenome.org/gene/83332:Rv1659 ^@ http://purl.uniprot.org/uniprot/P9WPY7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Argininosuccinate lyase ^@ http://purl.uniprot.org/annotation/PRO_0000137793 http://togogenome.org/gene/83332:Rv0299 ^@ http://purl.uniprot.org/uniprot/O07226 ^@ Molecule Processing ^@ Chain ^@ Toxin Rv0299 ^@ http://purl.uniprot.org/annotation/PRO_0000406883 http://togogenome.org/gene/83332:Rv3420c ^@ http://purl.uniprot.org/uniprot/I6YG32 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ N-acetyltransferase|||N-alpha-acetyltransferase RimI ^@ http://purl.uniprot.org/annotation/PRO_0000438820 http://togogenome.org/gene/83332:Rv3918c ^@ http://purl.uniprot.org/uniprot/Q1LVD4 ^@ Region ^@ Domain Extent ^@ AAA_31 ^@ http://togogenome.org/gene/83332:Rv2876 ^@ http://purl.uniprot.org/uniprot/P9WL39 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2876 ^@ http://purl.uniprot.org/annotation/PRO_0000104089 http://togogenome.org/gene/83332:Rv0120c ^@ http://purl.uniprot.org/uniprot/P9WNM9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Elongation factor G-like protein|||tr-type G ^@ http://purl.uniprot.org/annotation/PRO_0000091276 http://togogenome.org/gene/83332:Rv0774c ^@ http://purl.uniprot.org/uniprot/I6Y8R4 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Acyl-CoA:diacylglycerol acyltransferase ^@ http://purl.uniprot.org/annotation/PRO_5010161303 http://togogenome.org/gene/83332:Rv0958 ^@ http://purl.uniprot.org/uniprot/P71552 ^@ Region ^@ Domain Extent ^@ Sigma-54 factor interaction ^@ http://togogenome.org/gene/83332:Rv0602c ^@ http://purl.uniprot.org/uniprot/O07776 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Modified Residue ^@ 4-aspartylphosphate|||OmpR/PhoB-type|||Response regulatory|||Transcriptional regulatory protein TcrA ^@ http://purl.uniprot.org/annotation/PRO_0000391082 http://togogenome.org/gene/83332:Rv2307c ^@ http://purl.uniprot.org/uniprot/P9WLC7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2307c ^@ http://purl.uniprot.org/annotation/PRO_0000104016 http://togogenome.org/gene/83332:Rv1779c ^@ http://purl.uniprot.org/uniprot/O53930 ^@ Region ^@ Coiled-Coil|||Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0418 ^@ http://purl.uniprot.org/uniprot/P96264 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Lipid Binding|||Mass|||Signal Peptide ^@ Expressed in M.bovis, lipidated.|||N-palmitoyl cysteine|||PA|||Probable lipoprotein aminopeptidase LpqL|||Proton acceptor|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000434901 http://togogenome.org/gene/83332:Rv3550 ^@ http://purl.uniprot.org/uniprot/I6Y3U6 ^@ Molecule Processing ^@ Chain ^@ (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000452310 http://togogenome.org/gene/83332:Rv1278 ^@ http://purl.uniprot.org/uniprot/P9WM41 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1278 ^@ http://purl.uniprot.org/annotation/PRO_0000103782 http://togogenome.org/gene/83332:Rv1608c ^@ http://purl.uniprot.org/uniprot/P9WID9 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Strand|||Turn ^@ Cysteine sulfenic acid (-SOH) intermediate|||Putative peroxiredoxin Rv1608c|||Redox-active|||Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000396097 http://togogenome.org/gene/83332:Rv2456c ^@ http://purl.uniprot.org/uniprot/P9WJX1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized MFS-type transporter Rv2456c ^@ http://purl.uniprot.org/annotation/PRO_0000390684 http://togogenome.org/gene/83332:Rv0239 ^@ http://purl.uniprot.org/uniprot/P9WJ41 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB24 ^@ http://purl.uniprot.org/annotation/PRO_0000408069 http://togogenome.org/gene/83332:Rv2275 ^@ http://purl.uniprot.org/uniprot/P9WPF9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand ^@ Complete loss of cYY-forming activity.|||Cyclo(L-tyrosyl-L-tyrosyl) synthase|||Nucleophile|||Small but detectable amount of cYY-forming activity.|||Small but detectable amount of catalytic activity (200-fold decrease). ^@ http://purl.uniprot.org/annotation/PRO_0000423356 http://togogenome.org/gene/83332:Rv0335c ^@ http://purl.uniprot.org/uniprot/L7N648 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5003982483 http://togogenome.org/gene/83332:Rv3350c ^@ http://purl.uniprot.org/uniprot/Q6MWX8 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv3099c ^@ http://purl.uniprot.org/uniprot/O05777 ^@ Region ^@ Domain Extent ^@ MDMPI_C|||MDMPI_N ^@ http://togogenome.org/gene/83332:Rv2757c ^@ http://purl.uniprot.org/uniprot/P9WF91 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ PINc|||Ribonuclease VapC21 ^@ http://purl.uniprot.org/annotation/PRO_0000407880 http://togogenome.org/gene/83332:Rv0003 ^@ http://purl.uniprot.org/uniprot/P9WHI9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ DNA replication and repair protein RecF ^@ http://purl.uniprot.org/annotation/PRO_0000196435 http://togogenome.org/gene/83332:Rv1194c ^@ http://purl.uniprot.org/uniprot/O05296 ^@ Region ^@ Domain Extent ^@ GGDEF_2|||HTH_30 ^@ http://togogenome.org/gene/83332:Rv2574 ^@ http://purl.uniprot.org/uniprot/P9WL87 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2574 ^@ http://purl.uniprot.org/annotation/PRO_0000104054 http://togogenome.org/gene/83332:Rv2933 ^@ http://purl.uniprot.org/uniprot/P96202 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Carrier|||For beta-ketoacyl synthase activity|||For dehydratase activity|||For malonyltransferase activity|||Ketosynthase family 3 (KS3)|||Lack of dehydration reaction.|||Lack of phosphopantetheinylation.|||N-acetylthreonine|||O-(pantetheine 4'-phosphoryl)serine|||Phenolphthiocerol/phthiocerol polyketide synthase subunit C|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000406948 http://togogenome.org/gene/83332:Rv0129c ^@ http://purl.uniprot.org/uniprot/P9WQN9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Sequence Conflict|||Signal Peptide|||Strand|||Turn ^@ Diacylglycerol acyltransferase/mycolyltransferase Ag85C|||Do not form alpha,alpha-trehalose dimycolate (TDM, cord factor) and alpha,alpha-trehalose monomycolate (TMM).|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000000226 http://togogenome.org/gene/83332:Rv0645c ^@ http://purl.uniprot.org/uniprot/P9WPB1 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Mycolic acid methyltransferase MmaA1 ^@ http://purl.uniprot.org/annotation/PRO_0000096504 http://togogenome.org/gene/83332:Rv3777 ^@ http://purl.uniprot.org/uniprot/P72043 ^@ Region ^@ Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv1306 ^@ http://purl.uniprot.org/uniprot/P9WPV5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ATP synthase subunit b|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000082381 http://togogenome.org/gene/83332:Rv1798 ^@ http://purl.uniprot.org/uniprot/P9WPI1 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ ESX-5 secretion system protein EccA5|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000063046 http://togogenome.org/gene/83332:Rv3339c ^@ http://purl.uniprot.org/uniprot/P9WKL1 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Isocitrate dehydrogenase [NADP]|||Phosphoserine ^@ http://purl.uniprot.org/annotation/PRO_0000083555 http://togogenome.org/gene/83332:Rv0262c ^@ http://purl.uniprot.org/uniprot/P9WQG9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Aminoglycoside 2'-N-acetyltransferase|||N-acetyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000064412 http://togogenome.org/gene/83332:Rv1448c ^@ http://purl.uniprot.org/uniprot/P9WG33 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Schiff-base intermediate with substrate|||Transaldolase ^@ http://purl.uniprot.org/annotation/PRO_0000173636 http://togogenome.org/gene/83332:Rv1618 ^@ http://purl.uniprot.org/uniprot/O06135 ^@ Region ^@ Domain Extent ^@ Acyl_CoA_thio ^@ http://togogenome.org/gene/83332:Rv2799 ^@ http://purl.uniprot.org/uniprot/I6XFB7 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1810 ^@ http://purl.uniprot.org/uniprot/O07222 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ DUF732 ^@ http://purl.uniprot.org/annotation/PRO_5004157079 http://togogenome.org/gene/83332:Rv1754c ^@ http://purl.uniprot.org/uniprot/O06790 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ DUF4185|||Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2627c ^@ http://purl.uniprot.org/uniprot/P9WL67 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2627c ^@ http://purl.uniprot.org/annotation/PRO_0000392935 http://togogenome.org/gene/83332:Rv3464 ^@ http://purl.uniprot.org/uniprot/P9WN65 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Proton donor|||dTDP-glucose 4,6-dehydratase ^@ http://purl.uniprot.org/annotation/PRO_0000395348 http://togogenome.org/gene/83332:Rv2426c ^@ http://purl.uniprot.org/uniprot/P71922 ^@ Region ^@ Domain Extent ^@ AAA ^@ http://togogenome.org/gene/83332:Rv3281 ^@ http://purl.uniprot.org/uniprot/P96886 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase epsilon subunit|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000452371 http://togogenome.org/gene/83332:Rv0167 ^@ http://purl.uniprot.org/uniprot/O07412 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3619c ^@ http://purl.uniprot.org/uniprot/P0DOA6|||http://purl.uniprot.org/uniprot/P0DOA7 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ ESAT-6-like protein EsxI|||ESAT-6-like protein EsxV ^@ http://purl.uniprot.org/annotation/PRO_0000167800|||http://purl.uniprot.org/annotation/PRO_0000436928 http://togogenome.org/gene/83332:Rv1398c ^@ http://purl.uniprot.org/uniprot/P9WLZ1 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB10 ^@ http://purl.uniprot.org/annotation/PRO_0000103837 http://togogenome.org/gene/83332:Rv3789 ^@ http://purl.uniprot.org/uniprot/P9WMS9 ^@ Molecule Processing|||Region ^@ Chain|||Topological Domain|||Transmembrane ^@ Arabinogalactan biosynthesis recruiting protein Rv3789|||Cytoplasmic|||Helical|||Periplasmic ^@ http://purl.uniprot.org/annotation/PRO_0000212257 http://togogenome.org/gene/83332:Rv3116 ^@ http://purl.uniprot.org/uniprot/L7N674 ^@ Region ^@ Domain Extent ^@ Rhodanese ^@ http://togogenome.org/gene/83332:Rv3434c ^@ http://purl.uniprot.org/uniprot/I6YC44 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0822c ^@ http://purl.uniprot.org/uniprot/I6WZI4 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||LytR_C|||LytR_cpsA_psr|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0786c ^@ http://purl.uniprot.org/uniprot/P71839 ^@ Molecule Processing ^@ Chain ^@ Protein Rv0786c ^@ http://purl.uniprot.org/annotation/PRO_0000455999 http://togogenome.org/gene/83332:Rv0968 ^@ http://purl.uniprot.org/uniprot/P9WKL9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0968 ^@ http://purl.uniprot.org/annotation/PRO_0000103765 http://togogenome.org/gene/83332:Rv2319c ^@ http://purl.uniprot.org/uniprot/P9WLB5 ^@ Molecule Processing ^@ Chain ^@ Universal stress protein Rv2319c ^@ http://purl.uniprot.org/annotation/PRO_0000104026 http://togogenome.org/gene/83332:Rv0428c ^@ http://purl.uniprot.org/uniprot/P96274 ^@ Molecule Processing ^@ Chain ^@ Probable histone acetyltransferase Rv0428c ^@ http://purl.uniprot.org/annotation/PRO_0000456584 http://togogenome.org/gene/83332:Rv3561 ^@ http://purl.uniprot.org/uniprot/P96843 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000430639 http://togogenome.org/gene/83332:Rv0790c ^@ http://purl.uniprot.org/uniprot/I6XWA9 ^@ Region ^@ Domain Extent ^@ TGc ^@ http://togogenome.org/gene/83332:Rv1288 ^@ http://purl.uniprot.org/uniprot/P9WM39 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ 85% reduction of activity.|||Complete loss of activity.|||Esterase Rv1288|||LysM 1|||LysM 2|||LysM 3 ^@ http://purl.uniprot.org/annotation/PRO_0000103786 http://togogenome.org/gene/83332:Rv2469c ^@ http://purl.uniprot.org/uniprot/O53196 ^@ Region ^@ Domain Extent ^@ HNHc ^@ http://togogenome.org/gene/83332:Rv2971 ^@ http://purl.uniprot.org/uniprot/P9WQA5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton donor|||Uncharacterized oxidoreductase Rv2971 ^@ http://purl.uniprot.org/annotation/PRO_0000380747 http://togogenome.org/gene/83332:Rv0453 ^@ http://purl.uniprot.org/uniprot/P9WI39 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ PPE family protein PPE11|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000379585 http://togogenome.org/gene/83332:Rv3468c ^@ http://purl.uniprot.org/uniprot/Q6MWX3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Epimerase ^@ http://purl.uniprot.org/annotation/PRO_5010321236 http://togogenome.org/gene/83332:Rv0188 ^@ http://purl.uniprot.org/uniprot/O07432 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3669 ^@ http://purl.uniprot.org/uniprot/O69637 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3631 ^@ http://purl.uniprot.org/uniprot/O06376 ^@ Region ^@ Domain Extent ^@ Glyco_trans_2-like ^@ http://togogenome.org/gene/83332:Rv0014c ^@ http://purl.uniprot.org/uniprot/P9WI81 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Cytoplasmic|||Does not affect activity.|||Extracellular|||Helical|||Impairs kinase activity.|||Lack of autophosphorylation. Decreases affinity for FhaB.|||N-acetylthreonine|||PASTA 1|||PASTA 2|||PASTA 3|||PASTA 4|||Phosphoserine; by autocatalysis|||Phosphothreonine; by autocatalysis|||Protein kinase|||Proton acceptor|||Reduces activity and autophosphorylation. Decreases interaction with GarA.|||Removed|||Serine/threonine-protein kinase PknB ^@ http://purl.uniprot.org/annotation/PRO_0000171208 http://togogenome.org/gene/83332:Rv1408 ^@ http://purl.uniprot.org/uniprot/P9WI51 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Proton donor|||Ribulose-phosphate 3-epimerase ^@ http://purl.uniprot.org/annotation/PRO_0000171578 http://togogenome.org/gene/83332:Rv1207 ^@ http://purl.uniprot.org/uniprot/P9WNC9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Inactive dihydropteroate synthase 2|||Pterin-binding ^@ http://purl.uniprot.org/annotation/PRO_0000168216 http://togogenome.org/gene/83332:Rv2585c ^@ http://purl.uniprot.org/uniprot/P9WL77 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||S-diacylglycerol cysteine|||Uncharacterized lipoprotein Rv2585c ^@ http://purl.uniprot.org/annotation/PRO_0000014137 http://togogenome.org/gene/83332:Rv2943 ^@ http://purl.uniprot.org/uniprot/I6X5T4 ^@ Region ^@ Domain Extent ^@ Integrase catalytic ^@ http://togogenome.org/gene/83332:Rv3444c ^@ http://purl.uniprot.org/uniprot/I6YC53 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxT ^@ http://purl.uniprot.org/annotation/PRO_0000436933 http://togogenome.org/gene/83332:Rv2416c ^@ http://purl.uniprot.org/uniprot/P9WFK7 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes catalytic activity on AG substrates.|||Decreases catalytic activity on AG substrates, leads to a change in the number of acetylated sites.|||N-acetyltransferase|||N-acetyltransferase Eis|||Nearly abolishes catalytic activity on AG substrates.|||No effect on catalytic activity on AG substrates. Prevents artifactual CoA adduct formation during crystallization.|||Proton acceptor; via carboxylate|||Proton donor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000220262 http://togogenome.org/gene/83332:Rv0132c ^@ http://purl.uniprot.org/uniprot/P96809 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Signal Peptide ^@ F420-dependent hydroxymycolic acid dehydrogenase|||Proton acceptor|||Proton donor|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000435125 http://togogenome.org/gene/83332:Rv1316c ^@ http://purl.uniprot.org/uniprot/P9WJW5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Methylated-DNA--protein-cysteine methyltransferase|||Nucleophile; methyl group acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000139369 http://togogenome.org/gene/83332:Rv3058c ^@ http://purl.uniprot.org/uniprot/P95100 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv3572 ^@ http://purl.uniprot.org/uniprot/I6X7P2 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Secreted protein ^@ http://purl.uniprot.org/annotation/PRO_5010190148 http://togogenome.org/gene/83332:Rv2174 ^@ http://purl.uniprot.org/uniprot/O53508 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ Alpha-(1->6)-mannopyranosyltransferase A|||Helical|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000420592 http://togogenome.org/gene/83332:Rv0803 ^@ http://purl.uniprot.org/uniprot/P9WHL7 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Sequence Conflict ^@ Phosphoribosylformylglycinamidine synthase subunit PurL|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000100473 http://togogenome.org/gene/83332:Rv0273c ^@ http://purl.uniprot.org/uniprot/O86342 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1988 ^@ http://purl.uniprot.org/uniprot/Q10838 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ rADc ^@ http://togogenome.org/gene/83332:Rv0928 ^@ http://purl.uniprot.org/uniprot/P9WGT7 ^@ Modification|||Molecule Processing|||Natural Variation|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Lipid Binding|||Sequence Variant|||Signal Peptide|||Strand ^@ In strain: Erdman.|||N-palmitoyl cysteine|||Phosphate-binding protein PstS 3|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000031859 http://togogenome.org/gene/83332:Rv1821 ^@ http://purl.uniprot.org/uniprot/P9WGP3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Protein translocase subunit SecA 2 ^@ http://purl.uniprot.org/annotation/PRO_0000109599 http://togogenome.org/gene/83332:Rv2643 ^@ http://purl.uniprot.org/uniprot/I6X4W4 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||LMWPc ^@ http://togogenome.org/gene/83332:Rv2288 ^@ http://purl.uniprot.org/uniprot/P9WLE5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2288 ^@ http://purl.uniprot.org/annotation/PRO_0000104007 http://togogenome.org/gene/83332:Rv3480c ^@ http://purl.uniprot.org/uniprot/P9WKA7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv3480c ^@ http://purl.uniprot.org/annotation/PRO_0000222920 http://togogenome.org/gene/83332:Rv2104c ^@ http://purl.uniprot.org/uniprot/P9WJ27 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB37 ^@ http://purl.uniprot.org/annotation/PRO_0000408079 http://togogenome.org/gene/83332:Rv2473 ^@ http://purl.uniprot.org/uniprot/O53200 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide|||Transmembrane ^@ Helical|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5010186602 http://togogenome.org/gene/83332:Rv1981c ^@ http://purl.uniprot.org/uniprot/P9WH73 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Sequence Conflict ^@ Ribonucleoside-diphosphate reductase subunit beta nrdF1 ^@ http://purl.uniprot.org/annotation/PRO_0000190486 http://togogenome.org/gene/83332:Rv0178 ^@ http://purl.uniprot.org/uniprot/O07422 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2438c ^@ http://purl.uniprot.org/uniprot/P9WJJ3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ CN hydrolase|||Causes a decrease in ammonia channel efficiency to 70% compared with wild-type enzyme.|||For glutaminase activity|||Glutamine-dependent NAD(+) synthetase|||Lack of glutamine-dependent activity. Retains 30% of ammonia-dependent activity.|||Lack of glutamine-dependent activity. Retains 90% of ammonia-dependent activity.|||Lack of glutamine-dependent and ammonia-dependent activities.|||Nucleophile; for glutaminase activity|||Proton acceptor; for glutaminase activity|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000152241 http://togogenome.org/gene/83332:Rv3291c ^@ http://purl.uniprot.org/uniprot/I6YBQ3 ^@ Region ^@ Domain Extent ^@ HTH asnC-type ^@ http://togogenome.org/gene/83332:Rv1935c ^@ http://purl.uniprot.org/uniprot/P95279 ^@ Molecule Processing ^@ Chain ^@ Putative enoyl-CoA hydratase EchA13 ^@ http://purl.uniprot.org/annotation/PRO_0000438539 http://togogenome.org/gene/83332:Rv0186A ^@ http://purl.uniprot.org/uniprot/P9WK09 ^@ Experimental Information|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Mass|||Propeptide ^@ Metallothionein ^@ http://purl.uniprot.org/annotation/PRO_0000401202|||http://purl.uniprot.org/annotation/PRO_0000401203 http://togogenome.org/gene/83332:Rv1715 ^@ http://purl.uniprot.org/uniprot/L7N688 ^@ Region ^@ Domain Extent ^@ 3HCDH|||3HCDH_N ^@ http://togogenome.org/gene/83332:Rv1327c ^@ http://purl.uniprot.org/uniprot/P9WQ17 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000054347 http://togogenome.org/gene/83332:Rv1508c ^@ http://purl.uniprot.org/uniprot/P71787 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0981 ^@ http://purl.uniprot.org/uniprot/P9WGM9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ 4-aspartylphosphate|||Abolishes phosphorylation. No loss of DNA-binding activity in vitro.|||No loss of phosphorylation.|||OmpR/PhoB-type|||Response regulator MprA|||Response regulatory ^@ http://purl.uniprot.org/annotation/PRO_0000308427 http://togogenome.org/gene/83332:Rv2332 ^@ http://purl.uniprot.org/uniprot/P9WK25 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Proton donor|||Putative malate oxidoreductase [NAD] ^@ http://purl.uniprot.org/annotation/PRO_0000160248 http://togogenome.org/gene/83332:Rv1472 ^@ http://purl.uniprot.org/uniprot/P9WNN7 ^@ Molecule Processing ^@ Chain ^@ Probable enoyl-CoA hydratase EchA12 ^@ http://purl.uniprot.org/annotation/PRO_0000109341 http://togogenome.org/gene/83332:Rv1298 ^@ http://purl.uniprot.org/uniprot/P9WHA1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 50S ribosomal protein L31 ^@ http://purl.uniprot.org/annotation/PRO_0000173132 http://togogenome.org/gene/83332:Rv2132 ^@ http://purl.uniprot.org/uniprot/O06243 ^@ Region ^@ Domain Extent ^@ RHH_1 ^@ http://togogenome.org/gene/83332:Rv2981c ^@ http://purl.uniprot.org/uniprot/P9WP31 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ ATP-grasp|||D-alanine--D-alanine ligase ^@ http://purl.uniprot.org/annotation/PRO_0000177844 http://togogenome.org/gene/83332:Rv1111c ^@ http://purl.uniprot.org/uniprot/O86351 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Basic and acidic residues|||DUF6542|||Helical ^@ http://togogenome.org/gene/83332:Rv0505c ^@ http://purl.uniprot.org/uniprot/P9WGJ3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ Helical|||Nucleophile|||Phosphoserine phosphatase SerB1|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000156893 http://togogenome.org/gene/83332:Rv3532 ^@ http://purl.uniprot.org/uniprot/P9WHX9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE61 ^@ http://purl.uniprot.org/annotation/PRO_0000379591 http://togogenome.org/gene/83332:Rv1957 ^@ http://purl.uniprot.org/uniprot/P95257 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylthreonine|||Removed|||SecB-like chaperone Rv1957 ^@ http://purl.uniprot.org/annotation/PRO_0000407372 http://togogenome.org/gene/83332:Rv3127 ^@ http://purl.uniprot.org/uniprot/P9WL07 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3127 ^@ http://purl.uniprot.org/annotation/PRO_0000392938 http://togogenome.org/gene/83332:Rv3679 ^@ http://purl.uniprot.org/uniprot/P9WKX5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Putative ATPase Rv3679 ^@ http://purl.uniprot.org/annotation/PRO_0000104143 http://togogenome.org/gene/83332:Rv1765c ^@ http://purl.uniprot.org/uniprot/O06798 ^@ Region ^@ Domain Extent ^@ HNHc ^@ http://togogenome.org/gene/83332:Rv3303c ^@ http://purl.uniprot.org/uniprot/P9WHH7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mass|||Strand|||Turn ^@ NAD(P)H dehydrogenase (quinone) ^@ http://purl.uniprot.org/annotation/PRO_0000391461 http://togogenome.org/gene/83332:Rv0024 ^@ http://purl.uniprot.org/uniprot/P71594 ^@ Region ^@ Domain Extent ^@ NlpC/P60 ^@ http://togogenome.org/gene/83332:Rv1418 ^@ http://purl.uniprot.org/uniprot/P9WK43 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Lipid Binding|||Signal Peptide|||Transmembrane ^@ Helical|||N-palmitoyl cysteine|||Putative lipoprotein LprH|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018148 http://togogenome.org/gene/83332:Rv2953 ^@ http://purl.uniprot.org/uniprot/P9WGV5 ^@ Molecule Processing ^@ Chain ^@ Trans-acting enoyl reductase ^@ http://purl.uniprot.org/annotation/PRO_0000304694 http://togogenome.org/gene/83332:Rv3456c ^@ http://purl.uniprot.org/uniprot/P9WHD3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 50S ribosomal protein L17|||Basic and acidic residues ^@ http://purl.uniprot.org/annotation/PRO_0000175536 http://togogenome.org/gene/83332:Rv0322 ^@ http://purl.uniprot.org/uniprot/O07248 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ Nucleophile|||UDPG_MGDP_dh_C ^@ http://togogenome.org/gene/83332:Rv2073c ^@ http://purl.uniprot.org/uniprot/P9WGR3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv2073c ^@ http://purl.uniprot.org/annotation/PRO_0000054864 http://togogenome.org/gene/83332:Rv3252c ^@ http://purl.uniprot.org/uniprot/O05895 ^@ Region ^@ Domain Extent|||Transmembrane ^@ FA_desaturase|||Helical ^@ http://togogenome.org/gene/83332:Rv3794 ^@ http://purl.uniprot.org/uniprot/P9WNL9 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure ^@ Chain|||Helix|||Sequence Conflict|||Sequence Variant|||Strand|||Transmembrane|||Turn ^@ Helical|||Probable arabinosyltransferase A|||Resistance to EMB. ^@ http://purl.uniprot.org/annotation/PRO_0000220564 http://togogenome.org/gene/83332:Rv0498 ^@ http://purl.uniprot.org/uniprot/P9WKU1 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv0498 ^@ http://purl.uniprot.org/annotation/PRO_0000014076 http://togogenome.org/gene/83332:Rv0991c ^@ http://purl.uniprot.org/uniprot/O05574 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ CxxC_CXXC_SSSS|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3069 ^@ http://purl.uniprot.org/uniprot/P9WP63 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative fluoride ion transporter CrcB 1 ^@ http://purl.uniprot.org/annotation/PRO_0000110137 http://togogenome.org/gene/83332:Rv0326 ^@ http://purl.uniprot.org/uniprot/O07251 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv3584 ^@ http://purl.uniprot.org/uniprot/P9WK63 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LpqE|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018124 http://togogenome.org/gene/83332:Rv0814c ^@ http://purl.uniprot.org/uniprot/P0CG95|||http://purl.uniprot.org/uniprot/P0CG96 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Uncharacterized protein Rv0814c|||Uncharacterized protein Rv3118 ^@ http://purl.uniprot.org/annotation/PRO_0000396084|||http://purl.uniprot.org/annotation/PRO_0000396092 http://togogenome.org/gene/83332:Rv0289 ^@ http://purl.uniprot.org/uniprot/P9WJC7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ ESX-3 secretion-associated protein EspG3 ^@ http://purl.uniprot.org/annotation/PRO_0000394154 http://togogenome.org/gene/83332:Rv1998c ^@ http://purl.uniprot.org/uniprot/P9WLN9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1998c ^@ http://purl.uniprot.org/annotation/PRO_0000103926 http://togogenome.org/gene/83332:Rv3764c ^@ http://purl.uniprot.org/uniprot/O69729 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||HAMP|||Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Probable sensor histidine kinase TcrY ^@ http://purl.uniprot.org/annotation/PRO_0000412200 http://togogenome.org/gene/83332:Rv0994 ^@ http://purl.uniprot.org/uniprot/P9WJQ7 ^@ Molecule Processing ^@ Chain ^@ Molybdopterin molybdenumtransferase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000170991 http://togogenome.org/gene/83332:Rv1122 ^@ http://purl.uniprot.org/uniprot/O06574 ^@ Region ^@ Domain Extent ^@ 6PGD ^@ http://togogenome.org/gene/83332:Rv3595c ^@ http://purl.uniprot.org/uniprot/Q6MWV6 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2655c ^@ http://purl.uniprot.org/uniprot/I6Y1F0 ^@ Region ^@ Domain Extent ^@ DUF3631 ^@ http://togogenome.org/gene/83332:Rv2298 ^@ http://purl.uniprot.org/uniprot/P9WQA7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton donor|||Uncharacterized oxidoreductase Rv2298 ^@ http://purl.uniprot.org/annotation/PRO_0000070396 http://togogenome.org/gene/83332:Rv3141 ^@ http://purl.uniprot.org/uniprot/P95185 ^@ Region ^@ Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv3490 ^@ http://purl.uniprot.org/uniprot/P9WN11 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Trehalose-6-phosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000348922 http://togogenome.org/gene/83332:Rv0938 ^@ http://purl.uniprot.org/uniprot/P9WNV3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||DNA Binding|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 20% ligase activity for singly nicked dsDNA, normal N6-AMP-lysine intermediate formed, no effect on phosphodiester bond formation, no effect on DNA polymerase.|||Basic and acidic residues|||Better than wild-type DNA-binding and filling on single nt gaps, impaired gap filling on more complicated templates (in Pol domain).|||Binds DNA, no formation of DNA end-bridging complex, no polymerase activity. Significantly decreased ability to fill in 2 nt gaps (in Pol domain).|||Binds DNA, no gap-filling (in Pol domain).|||Interaction with target DNA|||Loss of DNA-binding, no polymerase activity, no effect of gap-filling (in Pol domain).|||Loss of adenyltransferase activity, no N6-AMP-lysine formation and loss of ligase activity. No effect on phosphodiester bond formation on pre-adenylated nicked DNA, or on DNA polymerase.|||Loss of exonuclease, no DNA repair.|||Loss of polymerase activities, no DNA repair (in Pol domain).|||Multifunctional non-homologous end joining DNA repair protein LigD|||N6-AMP-lysine intermediate; for ligase activity|||No ligase of singly nicked dsDNA activity, 25% N6-AMP-lysine intermediate formed, decreased phosphodiester bond formation, no effect on DNA polymerase.|||No ligase of singly nicked dsDNA activity, no N6-AMP-lysine intermediate formed, decreased phosphodiester bond formation on pre-adenylated nicked DNA, no effect on DNA polymerase.|||No ligase of singly nicked dsDNA activity, no N6-AMP-lysine intermediate formed, no phosphodiester bond formation on pre-adenylated nicked DNA, no effect on DNA polymerase.|||On substrate with 5'-phosphate, 1 base pair (bp) complementarity and 1 nucleotide (nt) gap, greatly reduced DNA-binding and gap-filling. Barely detectable activity on substrate with high complementarity and 3'-overhang (in Pol domain).|||On substrate with 5'-phosphate, 1 bp complementarity and 1 nt gap, greatly reduced DNA-binding and gap-filling. Barely detectable activity on substrate with high complementarity and 3'-overhang (in Pol domain).|||On substrate with 5'-phosphate, 1 bp complementarity and 1 nt gap, greatly reduced DNA-binding and gap-filling. No activity on substrate with high complementarity and 3'-overhang (in Pol domain).|||Wild-type filling on single nt gaps, impaired gap filling on more complicated templates (in Pol domain). ^@ http://purl.uniprot.org/annotation/PRO_0000059627 http://togogenome.org/gene/83332:Rv2118c ^@ http://purl.uniprot.org/uniprot/P9WFZ1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand ^@ tRNA (adenine(58)-N(1))-methyltransferase TrmI ^@ http://purl.uniprot.org/annotation/PRO_0000407309 http://togogenome.org/gene/83332:Rv2485c ^@ http://purl.uniprot.org/uniprot/I6Y9F7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Esterase LipQ ^@ http://purl.uniprot.org/annotation/PRO_0000448881 http://togogenome.org/gene/83332:Rv2107 ^@ http://purl.uniprot.org/uniprot/L7N6B5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010346601 http://togogenome.org/gene/83332:Rv2963 ^@ http://purl.uniprot.org/uniprot/I6YET7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative permease Rv2963 ^@ http://purl.uniprot.org/annotation/PRO_0000433101 http://togogenome.org/gene/83332:Rv2448c ^@ http://purl.uniprot.org/uniprot/P9WFS9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Coiled-Coil|||Initiator Methionine|||Motif ^@ 'HIGH' region|||'KMSKS' region|||Removed|||Valine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000106232 http://togogenome.org/gene/83332:Rv0530A ^@ http://purl.uniprot.org/uniprot/V5QPR5 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv3229c ^@ http://purl.uniprot.org/uniprot/P9WNZ3 ^@ Experimental Information|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Mutagenesis Site ^@ Enhances catalytic activity and stability.|||NADPH-dependent stearoyl-CoA 9-desaturase ^@ http://purl.uniprot.org/annotation/PRO_0000392677 http://togogenome.org/gene/83332:Rv0280 ^@ http://purl.uniprot.org/uniprot/P9WI45 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE3 ^@ http://purl.uniprot.org/annotation/PRO_0000378474 http://togogenome.org/gene/83332:Rv2776c ^@ http://purl.uniprot.org/uniprot/O86347 ^@ Region ^@ Domain Extent ^@ 2Fe-2S ferredoxin-type|||FAD-binding FR-type ^@ http://togogenome.org/gene/83332:Rv1882c ^@ http://purl.uniprot.org/uniprot/O07749 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv1791 ^@ http://purl.uniprot.org/uniprot/Q79FK4 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010299502 http://togogenome.org/gene/83332:Rv0849 ^@ http://purl.uniprot.org/uniprot/P9WJX5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized MFS-type transporter Rv0849 ^@ http://purl.uniprot.org/annotation/PRO_0000390682 http://togogenome.org/gene/83332:Rv3080c ^@ http://purl.uniprot.org/uniprot/P9WI65 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ Loss of activity.|||Loss of activity; when associated with A-179.|||Loss of activity; when associated with A-181.|||Phosphothreonine; by autocatalysis|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknK ^@ http://purl.uniprot.org/annotation/PRO_0000171224 http://togogenome.org/gene/83332:Rv0337c ^@ http://purl.uniprot.org/uniprot/P9WQ91 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue ^@ Alanine aminotransferase|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000123843 http://togogenome.org/gene/83332:Rv1518 ^@ http://purl.uniprot.org/uniprot/P9WLV9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1518 ^@ http://purl.uniprot.org/annotation/PRO_0000103865 http://togogenome.org/gene/83332:Rv2742c ^@ http://purl.uniprot.org/uniprot/O33285 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Putative envelope-preserving system protein Rv2742c ^@ http://purl.uniprot.org/annotation/PRO_0000450867 http://togogenome.org/gene/83332:Rv1176c ^@ http://purl.uniprot.org/uniprot/O50432 ^@ Region ^@ Domain Extent ^@ PadR|||Vir_act_alpha_C ^@ http://togogenome.org/gene/83332:Rv2179c ^@ http://purl.uniprot.org/uniprot/P9WJ73 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 3'-5' exoribonuclease Rv2179c|||Strongly reduces enzyme activity. ^@ http://purl.uniprot.org/annotation/PRO_0000424958 http://togogenome.org/gene/83332:Rv1831 ^@ http://purl.uniprot.org/uniprot/P9WLR3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1831 ^@ http://purl.uniprot.org/annotation/PRO_0000103905 http://togogenome.org/gene/83332:Rv2991 ^@ http://purl.uniprot.org/uniprot/O53240 ^@ Modification|||Region ^@ Domain Extent|||Modified Residue ^@ Cysteine sulfenic acid (-SOH)|||Putative_PNPOx ^@ http://togogenome.org/gene/83332:Rv2143 ^@ http://purl.uniprot.org/uniprot/O06232 ^@ Region ^@ Domain Extent ^@ Pribosyltran ^@ http://togogenome.org/gene/83332:Rv1634 ^@ http://purl.uniprot.org/uniprot/P9WJX3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable multidrug-efflux transporter Rv1634 ^@ http://purl.uniprot.org/annotation/PRO_0000390683 http://togogenome.org/gene/83332:Rv1968 ^@ http://purl.uniprot.org/uniprot/O53969 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Mce4_CUP1|||MlaD|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0599c ^@ http://purl.uniprot.org/uniprot/O07779 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Antitoxin VapB27|||SpoVT-AbrB ^@ http://purl.uniprot.org/annotation/PRO_0000408044 http://togogenome.org/gene/83332:Rv1464 ^@ http://purl.uniprot.org/uniprot/P9WQ69 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Initiator Methionine|||Modified Residue ^@ Cysteine persulfide intermediate|||N-acetylthreonine|||N6-(pyridoxal phosphate)lysine|||Probable cysteine desulfurase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000150304 http://togogenome.org/gene/83332:Rv3690 ^@ http://purl.uniprot.org/uniprot/O69658 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DUF4129|||Helical ^@ http://togogenome.org/gene/83332:Rv1776c ^@ http://purl.uniprot.org/uniprot/O33179 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1428c ^@ http://purl.uniprot.org/uniprot/O06830 ^@ Region ^@ Domain Extent ^@ PlsC ^@ http://togogenome.org/gene/83332:Rv1840c ^@ http://purl.uniprot.org/uniprot/P9WIF3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||PE|||Uncharacterized PE-PGRS family protein PE_PGRS34 ^@ http://purl.uniprot.org/annotation/PRO_0000216165 http://togogenome.org/gene/83332:Rv0860 ^@ http://purl.uniprot.org/uniprot/O53872 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ 3HCDH|||3HCDH_N ^@ http://togogenome.org/gene/83332:Rv2083 ^@ http://purl.uniprot.org/uniprot/P9WLK3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Pro residues|||Uncharacterized protein Rv2083 ^@ http://purl.uniprot.org/annotation/PRO_0000103954 http://togogenome.org/gene/83332:Rv3806c ^@ http://purl.uniprot.org/uniprot/P9WFR5 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Decaprenyl-phosphate phosphoribosyltransferase|||Extracellular|||Helical|||No DPPR synthase activity and the protein is not expressed in the membrane.|||No DPPR synthase activity.|||Only small effects on the DPPR synthase activity.|||Slight DPPR synthase activity.|||Substantially reduced the DPPR synthase activity.|||The DPPR synthase activity is strongly diminished. ^@ http://purl.uniprot.org/annotation/PRO_0000420587 http://togogenome.org/gene/83332:Rv3262 ^@ http://purl.uniprot.org/uniprot/P9WP79 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Bifunctional F420 biosynthesis protein FbiB ^@ http://purl.uniprot.org/annotation/PRO_0000145780 http://togogenome.org/gene/83332:Rv0509 ^@ http://purl.uniprot.org/uniprot/P9WMP7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Glutamyl-tRNA reductase|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000114042 http://togogenome.org/gene/83332:Rv0154c ^@ http://purl.uniprot.org/uniprot/P96831 ^@ Molecule Processing ^@ Chain ^@ Probable acyl-CoA dehydrogenase FadE2 ^@ http://purl.uniprot.org/annotation/PRO_0000455761 http://togogenome.org/gene/83332:Rv1003 ^@ http://purl.uniprot.org/uniprot/P9WGW7 ^@ Molecule Processing ^@ Chain ^@ Ribosomal RNA small subunit methyltransferase I ^@ http://purl.uniprot.org/annotation/PRO_0000211946 http://togogenome.org/gene/83332:Rv2753c ^@ http://purl.uniprot.org/uniprot/P9WP25 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 4-hydroxy-tetrahydrodipicolinate synthase|||Exists as dimer in solution. Has similar activity to the wild-type enzyme. Slight decrease in affinity for substrates.|||Proton donor/acceptor|||Schiff-base intermediate with substrate ^@ http://purl.uniprot.org/annotation/PRO_0000103128 http://togogenome.org/gene/83332:Rv3635 ^@ http://purl.uniprot.org/uniprot/I6Y460 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3597c ^@ http://purl.uniprot.org/uniprot/P9WIP7 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Loss of DNA-binding, in fragment 66-112.|||Loss of activity.|||Loss of activity. Can form dimers but does not bind DNA.|||No change in activity. Can still bind DNA and form dimers.|||Nucleoid-associated protein Lsr2|||Reduced DNA-binding, in fragment 66-112. ^@ http://purl.uniprot.org/annotation/PRO_0000021625 http://togogenome.org/gene/83332:Rv0825c ^@ http://purl.uniprot.org/uniprot/O53836 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1088 ^@ http://purl.uniprot.org/uniprot/Q79FS8 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE family protein PE9 ^@ http://purl.uniprot.org/annotation/PRO_0000438135 http://togogenome.org/gene/83332:Rv1656 ^@ http://purl.uniprot.org/uniprot/P9WIT9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Ornithine carbamoyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000112955 http://togogenome.org/gene/83332:Rv0631c ^@ http://purl.uniprot.org/uniprot/P9WIQ5 ^@ Molecule Processing ^@ Chain ^@ RecBCD enzyme subunit RecC ^@ http://purl.uniprot.org/annotation/PRO_0000087122 http://togogenome.org/gene/83332:Rv1132 ^@ http://purl.uniprot.org/uniprot/O06583 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1487 ^@ http://purl.uniprot.org/uniprot/P71767 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||NfeD ^@ http://togogenome.org/gene/83332:Rv0950c ^@ http://purl.uniprot.org/uniprot/P71560 ^@ Region ^@ Domain Extent ^@ Peptidase_M23 ^@ http://togogenome.org/gene/83332:Rv3152 ^@ http://purl.uniprot.org/uniprot/P9WIX1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||NADH-quinone oxidoreductase subunit H ^@ http://purl.uniprot.org/annotation/PRO_0000117529 http://togogenome.org/gene/83332:Rv2497c ^@ http://purl.uniprot.org/uniprot/P9WIS3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 3-methyl-2-oxobutanoate dehydrogenase subunit alpha ^@ http://purl.uniprot.org/annotation/PRO_0000420518 http://togogenome.org/gene/83332:Rv3891c ^@ http://purl.uniprot.org/uniprot/O05453 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxD ^@ http://purl.uniprot.org/annotation/PRO_0000436931 http://togogenome.org/gene/83332:Rv2973c ^@ http://purl.uniprot.org/uniprot/P9WMQ7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ ATP-dependent DNA helicase RecG|||DEQH box|||Helicase ATP-binding|||Helicase C-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000102146 http://togogenome.org/gene/83332:Rv0638 ^@ http://purl.uniprot.org/uniprot/P9WGN7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Protein translocase subunit SecE ^@ http://purl.uniprot.org/annotation/PRO_0000104168 http://togogenome.org/gene/83332:Rv1605 ^@ http://purl.uniprot.org/uniprot/P9WMM3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Imidazole glycerol phosphate synthase subunit HisF ^@ http://purl.uniprot.org/annotation/PRO_0000142185 http://togogenome.org/gene/83332:Rv2786c ^@ http://purl.uniprot.org/uniprot/I6X5C9 ^@ Region ^@ Domain Extent ^@ Flavokinase ^@ http://togogenome.org/gene/83332:Rv0029 ^@ http://purl.uniprot.org/uniprot/P71599 ^@ Region ^@ Domain Extent ^@ DUF5631|||DUF5632 ^@ http://togogenome.org/gene/83332:Rv3274c ^@ http://purl.uniprot.org/uniprot/P9WQG1 ^@ Molecule Processing ^@ Chain ^@ Probable acyl-CoA dehydrogenase FadE25 ^@ http://purl.uniprot.org/annotation/PRO_0000201188 http://togogenome.org/gene/83332:Rv3661 ^@ http://purl.uniprot.org/uniprot/P9WGJ1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Nucleophile|||Polar residues|||Probable phosphatase Rv3661|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000156895 http://togogenome.org/gene/83332:Rv2613c ^@ http://purl.uniprot.org/uniprot/P9WMK9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Motif|||Mutagenesis Site|||Strand|||Turn ^@ AP-4-A phosphorylase|||Abolishes enzyme activity.|||HIT|||Histidine triad motif|||Reduces enzyme activity.|||Tele-AMP-histidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000393106 http://togogenome.org/gene/83332:Rv3461c ^@ http://purl.uniprot.org/uniprot/P9WH89 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L36 ^@ http://purl.uniprot.org/annotation/PRO_0000126221 http://togogenome.org/gene/83332:Rv3090 ^@ http://purl.uniprot.org/uniprot/O05769 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||PHB ^@ http://togogenome.org/gene/83332:Rv3278c ^@ http://purl.uniprot.org/uniprot/P96883 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||bPH_2 ^@ http://togogenome.org/gene/83332:Rv2009 ^@ http://purl.uniprot.org/uniprot/P9WLM7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Turn ^@ Antitoxin VapB15 ^@ http://purl.uniprot.org/annotation/PRO_0000103938 http://togogenome.org/gene/83332:Rv0642c ^@ http://purl.uniprot.org/uniprot/Q79FX8 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mass|||Strand|||Turn ^@ Hydroxymycolate synthase MmaA4 ^@ http://purl.uniprot.org/annotation/PRO_0000398365 http://togogenome.org/gene/83332:Rv1842c ^@ http://purl.uniprot.org/uniprot/P9WFP3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ CBS 1|||CBS 2|||CNNM transmembrane|||Helical|||UPF0053 protein Rv1842c ^@ http://purl.uniprot.org/annotation/PRO_0000088380 http://togogenome.org/gene/83332:Rv2678c ^@ http://purl.uniprot.org/uniprot/P9WFE1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uroporphyrinogen decarboxylase ^@ http://purl.uniprot.org/annotation/PRO_0000187616 http://togogenome.org/gene/83332:Rv3004 ^@ http://purl.uniprot.org/uniprot/P9WIR1 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ Low molecular weight protein antigen 6 ^@ http://purl.uniprot.org/annotation/PRO_0000089575 http://togogenome.org/gene/83332:Rv2153c ^@ http://purl.uniprot.org/uniprot/P9WJK9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase ^@ http://purl.uniprot.org/annotation/PRO_0000109189 http://togogenome.org/gene/83332:Rv1644 ^@ http://purl.uniprot.org/uniprot/P94978 ^@ Region ^@ Domain Extent ^@ SpoU_sub_bind ^@ http://togogenome.org/gene/83332:Rv2507 ^@ http://purl.uniprot.org/uniprot/O06170 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1978 ^@ http://purl.uniprot.org/uniprot/O53979 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv3700c ^@ http://purl.uniprot.org/uniprot/O69668 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Probable hercynylcysteine sulfoxide lyase ^@ http://purl.uniprot.org/annotation/PRO_0000413654 http://togogenome.org/gene/83332:Rv1476 ^@ http://purl.uniprot.org/uniprot/O53167 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1439c ^@ http://purl.uniprot.org/uniprot/O06820 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv3622c ^@ http://purl.uniprot.org/uniprot/I6YGS7 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv3388 ^@ http://purl.uniprot.org/uniprot/Q6MWX5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5004277327 http://togogenome.org/gene/83332:Rv1983 ^@ http://purl.uniprot.org/uniprot/P9WIF1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ PE|||PE cleavage protein A ^@ http://purl.uniprot.org/annotation/PRO_0000216166 http://togogenome.org/gene/83332:Rv0870c ^@ http://purl.uniprot.org/uniprot/I6Y8Z3 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||YccF ^@ http://togogenome.org/gene/83332:Rv2453c ^@ http://purl.uniprot.org/uniprot/P9WJQ9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable molybdenum cofactor guanylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000134894 http://togogenome.org/gene/83332:Rv2094c ^@ http://purl.uniprot.org/uniprot/P9WGA1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Sec-independent protein translocase protein TatA ^@ http://purl.uniprot.org/annotation/PRO_0000097945 http://togogenome.org/gene/83332:Rv2624c ^@ http://purl.uniprot.org/uniprot/P9WFD5 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Universal stress protein Rv2624c ^@ http://purl.uniprot.org/annotation/PRO_0000392629 http://togogenome.org/gene/83332:Rv3818 ^@ http://purl.uniprot.org/uniprot/P9WH21 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Putative Rieske 2Fe-2S iron-sulfur protein Rv3818|||Rieske ^@ http://purl.uniprot.org/annotation/PRO_0000396106 http://togogenome.org/gene/83332:Rv2272 ^@ http://purl.uniprot.org/uniprot/P9WLF5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2272 ^@ http://purl.uniprot.org/annotation/PRO_0000103999 http://togogenome.org/gene/83332:Rv2764c ^@ http://purl.uniprot.org/uniprot/P9WFR9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Mutagenesis Site|||Strand|||Turn ^@ Appears to be functional by complementation study.|||Appears to be non-functional by complementation study.|||Nucleophile|||Removed|||Thymidylate synthase ThyA|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000140990 http://togogenome.org/gene/83332:Rv0839 ^@ http://purl.uniprot.org/uniprot/I6X9X6 ^@ Region ^@ Domain Extent ^@ Methyltranfer_dom ^@ http://togogenome.org/gene/83332:Rv3065 ^@ http://purl.uniprot.org/uniprot/P9WGF1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Multidrug resistance protein Mmr ^@ http://purl.uniprot.org/annotation/PRO_0000108120 http://togogenome.org/gene/83332:Rv1168c ^@ http://purl.uniprot.org/uniprot/P9WI27 ^@ Molecule Processing ^@ Chain ^@ PPE family protein PPE17 ^@ http://purl.uniprot.org/annotation/PRO_0000379109 http://togogenome.org/gene/83332:Rv1666c ^@ http://purl.uniprot.org/uniprot/P9WPM1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 139|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052300 http://togogenome.org/gene/83332:Rv3430c ^@ http://purl.uniprot.org/uniprot/I6YC39 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Integrase catalytic|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0308 ^@ http://purl.uniprot.org/uniprot/O07235 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||acidPPc ^@ http://togogenome.org/gene/83332:Rv1181 ^@ http://purl.uniprot.org/uniprot/A0A089QRB9 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Lipid Binding|||Modified Residue|||Signal Peptide ^@ Acyl-ester intermediate; for acyltransferase activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase activity|||Carrier|||For beta-ketoacyl synthase activity|||Ketosynthase family 3 (KS3)|||Mycolipanoate synthase|||N-palmitoyl cysteine|||O-(pantetheine 4'-phosphoryl)serine|||Proton acceptor; for dehydratase activity|||Proton donor; for dehydratase activity|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000438278 http://togogenome.org/gene/83332:Rv1145 ^@ http://purl.uniprot.org/uniprot/O06545 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MMPL ^@ http://togogenome.org/gene/83332:Rv1498c ^@ http://purl.uniprot.org/uniprot/P9WLW9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterised methyltransferase Rv1498c ^@ http://purl.uniprot.org/annotation/PRO_0000103860 http://togogenome.org/gene/83332:Rv0128 ^@ http://purl.uniprot.org/uniprot/P96805 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1313c ^@ http://purl.uniprot.org/uniprot/P9WKH7 ^@ Molecule Processing ^@ Chain ^@ Transposase for insertion sequence element IS1557 ^@ http://purl.uniprot.org/annotation/PRO_0000075450 http://togogenome.org/gene/83332:Rv0960 ^@ http://purl.uniprot.org/uniprot/P9WFA9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC9 ^@ http://purl.uniprot.org/annotation/PRO_0000103755 http://togogenome.org/gene/83332:Rv1795 ^@ http://purl.uniprot.org/uniprot/P9WNP9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-5 secretion system protein EccD5|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393237 http://togogenome.org/gene/83332:Rv1615 ^@ http://purl.uniprot.org/uniprot/O06132 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||TM2 ^@ http://togogenome.org/gene/83332:Rv2464c ^@ http://purl.uniprot.org/uniprot/P9WNB9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Initiator Methionine|||Zinc Finger ^@ Endonuclease 8 1|||FPG-type|||Proton donor|||Proton donor; for beta-elimination activity|||Proton donor; for delta-elimination activity|||Removed|||Schiff-base intermediate with DNA ^@ http://purl.uniprot.org/annotation/PRO_0000170903 http://togogenome.org/gene/83332:Rv3320c ^@ http://purl.uniprot.org/uniprot/P9WF53 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC44 ^@ http://purl.uniprot.org/annotation/PRO_0000407896 http://togogenome.org/gene/83332:Rv0041 ^@ http://purl.uniprot.org/uniprot/P9WFV1 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Motif|||Strand|||Turn ^@ 'HIGH' region|||'KMSKS' region|||Leucine--tRNA ligase|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000152052 http://togogenome.org/gene/83332:Rv3284 ^@ http://purl.uniprot.org/uniprot/P9WGC3 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Removed|||Uncharacterized SufE-like protein Rv3284 ^@ http://purl.uniprot.org/annotation/PRO_0000202140 http://togogenome.org/gene/83332:Rv0535 ^@ http://purl.uniprot.org/uniprot/O06401 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ S-methyl-5'-thioadenosine phosphorylase ^@ http://purl.uniprot.org/annotation/PRO_0000415096 http://togogenome.org/gene/83332:Rv3671c ^@ http://purl.uniprot.org/uniprot/P9WHR9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ Abolishes complementation of the Rv3671c mutant. It does not exhibit autocleavage activity.|||Helical|||Peptidase S1|||Proton acceptor|||Serine protease Rv3671c|||Significant decrease of protease activity. ^@ http://purl.uniprot.org/annotation/PRO_0000414589 http://togogenome.org/gene/83332:Rv2285 ^@ http://purl.uniprot.org/uniprot/P9WKB5 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv2285 ^@ http://purl.uniprot.org/annotation/PRO_0000222910 http://togogenome.org/gene/83332:Rv3472 ^@ http://purl.uniprot.org/uniprot/I6YG83 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv3101c ^@ http://purl.uniprot.org/uniprot/P9WG19 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Strand|||Topological Domain|||Transmembrane ^@ Cell division protein FtsX|||Cytoplasmic|||Extracellular|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000166797 http://togogenome.org/gene/83332:Rv0361 ^@ http://purl.uniprot.org/uniprot/O06311 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv3288c ^@ http://purl.uniprot.org/uniprot/L7N685 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1204c ^@ http://purl.uniprot.org/uniprot/O05305 ^@ Region ^@ Domain Extent ^@ AAA ^@ http://togogenome.org/gene/83332:Rv0161 ^@ http://purl.uniprot.org/uniprot/O07406 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv3786c ^@ http://purl.uniprot.org/uniprot/P9WKW9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv3786c ^@ http://purl.uniprot.org/annotation/PRO_0000014156 http://togogenome.org/gene/83332:Rv0653c ^@ http://purl.uniprot.org/uniprot/P96941 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1017c ^@ http://purl.uniprot.org/uniprot/P9WKE3 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Ribose-phosphate pyrophosphokinase ^@ http://purl.uniprot.org/annotation/PRO_0000141164 http://togogenome.org/gene/83332:Rv2199c ^@ http://purl.uniprot.org/uniprot/P9WP45 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable cytochrome c oxidase polypeptide 4 ^@ http://purl.uniprot.org/annotation/PRO_0000220019 http://togogenome.org/gene/83332:Rv3603c ^@ http://purl.uniprot.org/uniprot/O06279 ^@ Region ^@ Domain Extent ^@ DUF2520|||Rossmann-like ^@ http://togogenome.org/gene/83332:Rv2690c ^@ http://purl.uniprot.org/uniprot/I6Y1H7 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0479c ^@ http://purl.uniprot.org/uniprot/P9WKV7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||Uncharacterized protein Rv0479c ^@ http://purl.uniprot.org/annotation/PRO_0000103681 http://togogenome.org/gene/83332:Rv2517c ^@ http://purl.uniprot.org/uniprot/O53222 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv2371 ^@ http://purl.uniprot.org/uniprot/Q79FE9 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv0623 ^@ http://purl.uniprot.org/uniprot/P9WJ35 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Turn ^@ Antitoxin VapB30 ^@ http://purl.uniprot.org/annotation/PRO_0000408074 http://togogenome.org/gene/83332:Rv3739c ^@ http://purl.uniprot.org/uniprot/Q79FA2 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv0834c ^@ http://purl.uniprot.org/uniprot/Q79FV6 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv2315c ^@ http://purl.uniprot.org/uniprot/P71897 ^@ Region ^@ Domain Extent ^@ PmbA_TldD|||PmbA_TldD_C ^@ http://togogenome.org/gene/83332:Rv2807 ^@ http://purl.uniprot.org/uniprot/P71644 ^@ Region ^@ Domain Extent ^@ Integrase catalytic ^@ http://togogenome.org/gene/83332:Rv0052 ^@ http://purl.uniprot.org/uniprot/I6Y6S3 ^@ Region ^@ Domain Extent ^@ DJ-1_PfpI ^@ http://togogenome.org/gene/83332:Rv3167c ^@ http://purl.uniprot.org/uniprot/O53317 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2122c ^@ http://purl.uniprot.org/uniprot/P9WMM9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ Phosphoribosyl-ATP pyrophosphatase ^@ http://purl.uniprot.org/annotation/PRO_0000136371 http://togogenome.org/gene/83332:Rv1285 ^@ http://purl.uniprot.org/uniprot/P9WIK1 ^@ Molecule Processing ^@ Chain ^@ Sulfate adenylyltransferase subunit 2 ^@ http://purl.uniprot.org/annotation/PRO_0000100667 http://togogenome.org/gene/83332:Rv2147c ^@ http://purl.uniprot.org/uniprot/P9WGJ5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Cell division protein SepF ^@ http://purl.uniprot.org/annotation/PRO_0000334047 http://togogenome.org/gene/83332:Rv2978c ^@ http://purl.uniprot.org/uniprot/I6Y263 ^@ Region ^@ Domain Extent ^@ HTH_OrfB_IS605|||OrfB_IS605|||OrfB_Zn_ribbon ^@ http://togogenome.org/gene/83332:Rv2110c ^@ http://purl.uniprot.org/uniprot/P9WHT9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Mutagenesis Site|||Propeptide|||Strand|||Turn ^@ Loss of proteasome proteolytic activity. This mutant enables optimal growth in vitro and in vivo, confers RNI resistance but is not sufficient for persistence in mice.|||Nucleophile|||Proteasome subunit beta|||Removed in mature form; by autocatalysis ^@ http://purl.uniprot.org/annotation/PRO_0000383485|||http://purl.uniprot.org/annotation/PRO_0000383486 http://togogenome.org/gene/83332:Rv2635 ^@ http://purl.uniprot.org/uniprot/P9WL57 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv2635 ^@ http://purl.uniprot.org/annotation/PRO_0000014144 http://togogenome.org/gene/83332:Rv0397A ^@ http://purl.uniprot.org/uniprot/I6Y3N9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010179206 http://togogenome.org/gene/83332:Rv1538c ^@ http://purl.uniprot.org/uniprot/P9WPX5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ Asparaginase/glutaminase|||L-asparaginase|||O-isoaspartyl threonine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000171084 http://togogenome.org/gene/83332:Rv0175 ^@ http://purl.uniprot.org/uniprot/O07419 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3119 ^@ http://purl.uniprot.org/uniprot/P9WJR3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand ^@ Molybdopterin synthase catalytic subunit 1 ^@ http://purl.uniprot.org/annotation/PRO_0000163087 http://togogenome.org/gene/83332:Rv1678 ^@ http://purl.uniprot.org/uniprot/O53925 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2209 ^@ http://purl.uniprot.org/uniprot/P9WLI3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Uncharacterized protein Rv2209 ^@ http://purl.uniprot.org/annotation/PRO_0000103977 http://togogenome.org/gene/83332:Rv1191 ^@ http://purl.uniprot.org/uniprot/O05293 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv0319 ^@ http://purl.uniprot.org/uniprot/P9WIJ5 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Pyrrolidone-carboxylate peptidase ^@ http://purl.uniprot.org/annotation/PRO_0000184724 http://togogenome.org/gene/83332:Rv3441c ^@ http://purl.uniprot.org/uniprot/P9WN41 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Modified Residue ^@ Phosphoglucosamine mutase|||Phosphoserine|||Phosphoserine intermediate|||via phosphate group ^@ http://purl.uniprot.org/annotation/PRO_0000147918 http://togogenome.org/gene/83332:Rv1156 ^@ http://purl.uniprot.org/uniprot/O06554 ^@ Region ^@ Domain Extent ^@ ENDO3c ^@ http://togogenome.org/gene/83332:Rv1510 ^@ http://purl.uniprot.org/uniprot/P9WLW1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1510 ^@ http://purl.uniprot.org/annotation/PRO_0000103864 http://togogenome.org/gene/83332:Rv0139 ^@ http://purl.uniprot.org/uniprot/P96816 ^@ Region ^@ Domain Extent ^@ Epimerase ^@ http://togogenome.org/gene/83332:Rv0970 ^@ http://purl.uniprot.org/uniprot/P9WKL7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0970 ^@ http://purl.uniprot.org/annotation/PRO_0000103767 http://togogenome.org/gene/83332:Rv3710 ^@ http://purl.uniprot.org/uniprot/P9WQB3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Sequence Conflict|||Strand|||Turn ^@ 2-isopropylmalate synthase|||Pyruvate carboxyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000140436 http://togogenome.org/gene/83332:Rv1813c ^@ http://purl.uniprot.org/uniprot/P9WLS1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Signal Peptide|||Strand|||Turn ^@ Uncharacterized protein Rv1813c ^@ http://purl.uniprot.org/annotation/PRO_0000103898 http://togogenome.org/gene/83332:Rv1985c ^@ http://purl.uniprot.org/uniprot/P9WMF5 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ H-T-H motif|||HTH lysR-type|||HTH-type transcriptional regulator LysG|||Leads to dissociation into monomers. ^@ http://purl.uniprot.org/annotation/PRO_0000105812 http://togogenome.org/gene/83332:Rv2157c ^@ http://purl.uniprot.org/uniprot/P9WJL1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase ^@ http://purl.uniprot.org/annotation/PRO_0000101701 http://togogenome.org/gene/83332:Rv1626 ^@ http://purl.uniprot.org/uniprot/P9WGM3 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand ^@ 4-aspartylphosphate|||ANTAR|||N-acetylthreonine|||Probable transcriptional regulatory protein PdtaR|||Removed|||Response regulatory ^@ http://purl.uniprot.org/annotation/PRO_0000386597 http://togogenome.org/gene/83332:Rv2476c ^@ http://purl.uniprot.org/uniprot/O53203 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ NAD-specific glutamate dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000419536 http://togogenome.org/gene/83332:Rv3334 ^@ http://purl.uniprot.org/uniprot/O53384 ^@ Region ^@ Domain Extent ^@ HTH merR-type ^@ http://togogenome.org/gene/83332:Rv0546c ^@ http://purl.uniprot.org/uniprot/O06412 ^@ Region ^@ Domain Extent ^@ VOC ^@ http://togogenome.org/gene/83332:Rv3681c ^@ http://purl.uniprot.org/uniprot/P9WF39 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Mass|||Mutagenesis Site|||Strand|||Turn ^@ 4Fe-4S Wbl-type|||Apo-form does not bind DNA.|||Fully oxidized recombinant protein tagged at both termini.|||Fully reduced recombinant protein tagged at both termini.|||Partial loss of the Fe-S center. Complete loss of center and of disulfide reductase; when associated with S-37; S-59 and S-62.|||Partial loss of the Fe-S center. Complete loss of center and of disulfide reductase; when associated with S-37; S-59 and S-68.|||Partial loss of the Fe-S center. Complete loss of center and of disulfide reductase; when associated with S-37; S-62 and S-68.|||Partial loss of the Fe-S center. Complete loss of center and of disulfide reductase; when associated with S-59; S-62 and S-68.|||Transcriptional regulator WhiB4|||Upon loss of 4Fe-S clusters ^@ http://purl.uniprot.org/annotation/PRO_0000420383 http://togogenome.org/gene/83332:Rv2295 ^@ http://purl.uniprot.org/uniprot/P9WFL7 ^@ Molecule Processing ^@ Chain ^@ UPF0167 protein Rv2295 ^@ http://purl.uniprot.org/annotation/PRO_0000209366 http://togogenome.org/gene/83332:Rv0489 ^@ http://purl.uniprot.org/uniprot/P9WIC9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand ^@ 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase|||Proton donor/acceptor|||Tele-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000179893 http://togogenome.org/gene/83332:Rv0371c ^@ http://purl.uniprot.org/uniprot/I6WY86 ^@ Region ^@ Domain Extent ^@ NTP_transf_3 ^@ http://togogenome.org/gene/83332:Rv1215c ^@ http://purl.uniprot.org/uniprot/O05316 ^@ Region ^@ Domain Extent ^@ PepX_C ^@ http://togogenome.org/gene/83332:Rv2950c ^@ http://purl.uniprot.org/uniprot/P95141 ^@ Molecule Processing ^@ Chain ^@ 4-hydroxyphenylalkanoate adenylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000406357 http://togogenome.org/gene/83332:Rv3797 ^@ http://purl.uniprot.org/uniprot/O53577 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||AidB_N ^@ http://togogenome.org/gene/83332:Rv0663 ^@ http://purl.uniprot.org/uniprot/I6XVW9 ^@ Modification|||Region ^@ Domain Extent|||Modified Residue ^@ 3-oxoalanine (Cys)|||Sulfatase ^@ http://togogenome.org/gene/83332:Rv2423 ^@ http://purl.uniprot.org/uniprot/P71925 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv1027c ^@ http://purl.uniprot.org/uniprot/P9WGN1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ 4-aspartylphosphate|||Complete loss of phosphorylation.|||OmpR/PhoB-type|||Response regulatory|||Transcriptional regulatory protein KdpE ^@ http://purl.uniprot.org/annotation/PRO_0000412199 http://togogenome.org/gene/83332:Rv3616c ^@ http://purl.uniprot.org/uniprot/P9WJE1 ^@ Experimental Information|||Modification|||Molecule Processing ^@ Chain|||Disulfide Bond|||Mutagenesis Site ^@ Does not affect secretion, but inhibits disulfide bond formation. Alters mycobacterial cell wall integrity and significantly attenuates virulence.|||ESX-1 secretion-associated protein EspA|||Impairs EsxA and EsxB secretion in vitro. Modest impact on EspD stability and secretion. Attenuated in cellular models of tuberculosis infection.|||Interchain|||Severely destabilizes EspA and blocks ESX-1 secretion in vitro, but does not impact the cytotoxicity in cellular models of infection. Can induce pro-inflammatory responses in THP-1 cells and is as virulent as wild-type during the acute phase of infection in mice.|||Severely destabilizes EspA and blocks ESX-1 secretion in vitro. Attenuated in cellular models of tuberculosis infection. ^@ http://purl.uniprot.org/annotation/PRO_0000393903 http://togogenome.org/gene/83332:Rv0845 ^@ http://purl.uniprot.org/uniprot/O53857 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Transmembrane ^@ Complete loss of autophosphorylation.|||Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Sensor histidine kinase NarS ^@ http://purl.uniprot.org/annotation/PRO_0000401133 http://togogenome.org/gene/83332:Rv0490 ^@ http://purl.uniprot.org/uniprot/P9WGK5 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Transmembrane ^@ Helical|||Histidine kinase|||Phosphohistidine; by autocatalysis|||Sensor-like histidine kinase SenX3 ^@ http://purl.uniprot.org/annotation/PRO_0000074876 http://togogenome.org/gene/83332:Rv1323 ^@ http://purl.uniprot.org/uniprot/P9WG69 ^@ Molecule Processing|||Site ^@ Active Site|||Chain|||Initiator Methionine|||Propeptide ^@ Acyl-thioester intermediate|||Probable acetyl-CoA acetyltransferase|||Probable acetyl-CoA acetyltransferase, propeptide removed|||Proton acceptor|||Removed|||Removed; alternate ^@ http://purl.uniprot.org/annotation/PRO_0000206458|||http://purl.uniprot.org/annotation/PRO_0000455386|||http://purl.uniprot.org/annotation/PRO_0000455387 http://togogenome.org/gene/83332:Rv3873 ^@ http://purl.uniprot.org/uniprot/P9WHW9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Acidic residues|||PPE family immunomodulator PPE68 ^@ http://purl.uniprot.org/annotation/PRO_0000379593 http://togogenome.org/gene/83332:Rv3361c ^@ http://purl.uniprot.org/uniprot/I6YBX3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Pentapeptide repeat|||Pentapeptide repeat protein MfpA ^@ http://purl.uniprot.org/annotation/PRO_0000434153 http://togogenome.org/gene/83332:Rv1160 ^@ http://purl.uniprot.org/uniprot/P9WIY1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ Nudix box|||Nudix hydrolase|||Putative 8-oxo-dGTP diphosphatase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000391776 http://togogenome.org/gene/83332:Rv0934 ^@ http://purl.uniprot.org/uniprot/P9WGU1 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Lipid Binding|||Signal Peptide|||Strand|||Turn ^@ N-palmitoyl cysteine|||Phosphate-binding protein PstS 1|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000031854 http://togogenome.org/gene/83332:Rv2329c ^@ http://purl.uniprot.org/uniprot/P71883 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1995 ^@ http://purl.uniprot.org/uniprot/P9WLP3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1995 ^@ http://purl.uniprot.org/annotation/PRO_0000103922 http://togogenome.org/gene/83332:Rv2820c ^@ http://purl.uniprot.org/uniprot/A0A4Y5QPX8|||http://purl.uniprot.org/uniprot/P9WJF7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ CRISPR system Cms protein Csm4|||Csm4_C ^@ http://purl.uniprot.org/annotation/PRO_0000418227 http://togogenome.org/gene/83332:Rv0065 ^@ http://purl.uniprot.org/uniprot/P9WFC1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribonuclease VapC1 ^@ http://purl.uniprot.org/annotation/PRO_0000407864 http://togogenome.org/gene/83332:Rv3178 ^@ http://purl.uniprot.org/uniprot/O53328 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative F420H(2)-dependent quinone reductase Rv3178 ^@ http://purl.uniprot.org/annotation/PRO_0000399508 http://togogenome.org/gene/83332:Rv1295 ^@ http://purl.uniprot.org/uniprot/P9WG59 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Initiator Methionine|||Modified Residue|||Strand ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylthreonine|||N6-(pyridoxal phosphate)lysine|||Removed|||Threonine synthase ^@ http://purl.uniprot.org/annotation/PRO_0000185637 http://togogenome.org/gene/83332:Rv1828 ^@ http://purl.uniprot.org/uniprot/P9WME7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand ^@ H-T-H motif|||HTH merR-type|||Uncharacterized HTH-type transcriptional regulator Rv1828 ^@ http://purl.uniprot.org/annotation/PRO_0000098168 http://togogenome.org/gene/83332:Rv2988c ^@ http://purl.uniprot.org/uniprot/P9WQF5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 3-isopropylmalate dehydratase large subunit ^@ http://purl.uniprot.org/annotation/PRO_0000076766 http://togogenome.org/gene/83332:Rv2645 ^@ http://purl.uniprot.org/uniprot/P9WL51 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2645 ^@ http://purl.uniprot.org/annotation/PRO_0000104080 http://togogenome.org/gene/83332:Rv2824c ^@ http://purl.uniprot.org/uniprot/P9WPJ1 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ CRISPR-associated endoribonuclease Cas6|||Incorrect processing of pre-crRNA, binds pre-crRNA.|||Incorrect processing of pre-crRNA, no longer binds pre-crRNA. ^@ http://purl.uniprot.org/annotation/PRO_0000418222 http://togogenome.org/gene/83332:Rv3487c ^@ http://purl.uniprot.org/uniprot/O06350 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Motif|||Mutagenesis Site|||Propeptide ^@ Carboxylesterase/phospholipase LipF|||Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole|||Loss of activity. ^@ http://purl.uniprot.org/annotation/PRO_0000419168|||http://purl.uniprot.org/annotation/PRO_0000455443 http://togogenome.org/gene/83332:Rv0718 ^@ http://purl.uniprot.org/uniprot/P9WH27 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S8 ^@ http://purl.uniprot.org/annotation/PRO_0000126448 http://togogenome.org/gene/83332:Rv2788 ^@ http://purl.uniprot.org/uniprot/I6Y1Q2 ^@ Region ^@ Domain Extent ^@ HTH dtxR-type ^@ http://togogenome.org/gene/83332:Rv3426 ^@ http://purl.uniprot.org/uniprot/Q50702 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE58 ^@ http://purl.uniprot.org/annotation/PRO_0000217854 http://togogenome.org/gene/83332:Rv1550 ^@ http://purl.uniprot.org/uniprot/P9WQ53 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative fatty-acid--CoA ligase fadD11 ^@ http://purl.uniprot.org/annotation/PRO_0000193133 http://togogenome.org/gene/83332:Rv3300c ^@ http://purl.uniprot.org/uniprot/O07166 ^@ Region ^@ Domain Extent ^@ PseudoU_synth_2 ^@ http://togogenome.org/gene/83332:Rv0010c ^@ http://purl.uniprot.org/uniprot/P9WMA3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0010c ^@ http://purl.uniprot.org/annotation/PRO_0000103641 http://togogenome.org/gene/83332:Rv2219 ^@ http://purl.uniprot.org/uniprot/P9WLI1 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2219 ^@ http://purl.uniprot.org/annotation/PRO_0000014126 http://togogenome.org/gene/83332:Rv0329c ^@ http://purl.uniprot.org/uniprot/O07253 ^@ Region ^@ Domain Extent ^@ Methyltransf_11 ^@ http://togogenome.org/gene/83332:Rv3451 ^@ http://purl.uniprot.org/uniprot/P9WP39 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Signal Peptide ^@ Nucleophile|||Probable carboxylesterase Culp3|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000006451 http://togogenome.org/gene/83332:Rv0149 ^@ http://purl.uniprot.org/uniprot/P96826 ^@ Region ^@ Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv0988 ^@ http://purl.uniprot.org/uniprot/O86370 ^@ Region ^@ Domain Extent ^@ CrtC ^@ http://togogenome.org/gene/83332:Rv1858 ^@ http://purl.uniprot.org/uniprot/P9WG13 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical|||Molybdenum transport system permease protein ModB ^@ http://purl.uniprot.org/annotation/PRO_0000060116 http://togogenome.org/gene/83332:Rv0633c ^@ http://purl.uniprot.org/uniprot/P96923 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1824 ^@ http://purl.uniprot.org/uniprot/P9WLR7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1824 ^@ http://purl.uniprot.org/annotation/PRO_0000103900 http://togogenome.org/gene/83332:Rv0810c ^@ http://purl.uniprot.org/uniprot/I6XWB9 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2171 ^@ http://purl.uniprot.org/uniprot/O53505 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Lipid Binding|||Mutagenesis Site|||Signal Peptide|||Strand|||Transmembrane|||Turn ^@ Helical|||N-palmitoyl cysteine|||Protein LppM|||Remains cell wall associated, no difference in gel migration, upon overexpression in M.smegmatis.|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_5004158821 http://togogenome.org/gene/83332:Rv1636 ^@ http://purl.uniprot.org/uniprot/P9WFC9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Universal stress protein Rv1636 ^@ http://purl.uniprot.org/annotation/PRO_0000396947 http://togogenome.org/gene/83332:Rv2489c ^@ http://purl.uniprot.org/uniprot/O53214 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv3351c ^@ http://purl.uniprot.org/uniprot/O50380 ^@ Region ^@ Domain Extent ^@ BBE ^@ http://togogenome.org/gene/83332:Rv0270 ^@ http://purl.uniprot.org/uniprot/P95227 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv2305 ^@ http://purl.uniprot.org/uniprot/P9WLD1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2305 ^@ http://purl.uniprot.org/annotation/PRO_0000104015 http://togogenome.org/gene/83332:Rv0558 ^@ http://purl.uniprot.org/uniprot/P9WFR3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Demethylmenaquinone methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000193297 http://togogenome.org/gene/83332:Rv3576 ^@ http://purl.uniprot.org/uniprot/I6YGJ4 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PknH_C ^@ http://purl.uniprot.org/annotation/PRO_5010219482 http://togogenome.org/gene/83332:Rv2142A ^@ http://purl.uniprot.org/uniprot/P9WJ75 ^@ Molecule Processing ^@ Chain ^@ Antitoxin ParD2 ^@ http://purl.uniprot.org/annotation/PRO_0000408461 http://togogenome.org/gene/83332:Rv3138 ^@ http://purl.uniprot.org/uniprot/P95188 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ Radical SAM core ^@ http://togogenome.org/gene/83332:Rv3808c ^@ http://purl.uniprot.org/uniprot/O53585 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 1200-fold decrease in transferase activity. No effect on affinity for the substrate UDP-Galf.|||1400-fold decrease in transferase activity. No effect on affinity for the substrate UDP-Galf.|||1700-fold decrease in transferase activity. No effect on affinity for the substrate UDP-Galf.|||Galactofuranosyltransferase GlfT2|||Loss of transferase activity.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000395356 http://togogenome.org/gene/83332:Rv2435c ^@ http://purl.uniprot.org/uniprot/P71914 ^@ Region ^@ Coiled-Coil|||Domain Extent|||Transmembrane ^@ Guanylate cyclase|||HAMP|||Helical ^@ http://togogenome.org/gene/83332:Rv0500 ^@ http://purl.uniprot.org/uniprot/P9WHU7 ^@ Molecule Processing ^@ Chain ^@ Pyrroline-5-carboxylate reductase ^@ http://purl.uniprot.org/annotation/PRO_0000187294 http://togogenome.org/gene/83332:Rv1334 ^@ http://purl.uniprot.org/uniprot/P9WHS1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ CysO-cysteine peptidase|||JAMM motif|||MPN ^@ http://purl.uniprot.org/annotation/PRO_0000014095 http://togogenome.org/gene/83332:Rv1173 ^@ http://purl.uniprot.org/uniprot/P9WP77 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ FO synthase|||Radical SAM core 1|||Radical SAM core 2 ^@ http://purl.uniprot.org/annotation/PRO_0000147772 http://togogenome.org/gene/83332:Rv3372 ^@ http://purl.uniprot.org/uniprot/P9WFZ5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Nucleophile|||Trehalose-phosphate phosphatase ^@ http://purl.uniprot.org/annotation/PRO_0000370706 http://togogenome.org/gene/83332:Rv2005c ^@ http://purl.uniprot.org/uniprot/P9WLN1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Universal stress protein Rv2005c ^@ http://purl.uniprot.org/annotation/PRO_0000103934 http://togogenome.org/gene/83332:Rv1647 ^@ http://purl.uniprot.org/uniprot/P94982 ^@ Region ^@ Domain Extent ^@ Guanylate cyclase ^@ http://togogenome.org/gene/83332:Rv0075 ^@ http://purl.uniprot.org/uniprot/O53620 ^@ Region ^@ Domain Extent ^@ Aminotran_1_2 ^@ http://togogenome.org/gene/83332:Rv3192 ^@ http://purl.uniprot.org/uniprot/O53338 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv1838c ^@ http://purl.uniprot.org/uniprot/P9WFA1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC13 ^@ http://purl.uniprot.org/annotation/PRO_0000103911 http://togogenome.org/gene/83332:Rv1305 ^@ http://purl.uniprot.org/uniprot/P9WPS1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ATP synthase subunit c|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000112155 http://togogenome.org/gene/83332:Rv2657c ^@ http://purl.uniprot.org/uniprot/I6YE30 ^@ Region ^@ Domain Extent ^@ HTH_17 ^@ http://togogenome.org/gene/83332:Rv3497c ^@ http://purl.uniprot.org/uniprot/I6YGB1 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MlaD ^@ http://togogenome.org/gene/83332:Rv0728c ^@ http://purl.uniprot.org/uniprot/I6WZ71 ^@ Region ^@ Domain Extent ^@ 2-Hacid_dh|||2-Hacid_dh_C ^@ http://togogenome.org/gene/83332:Rv3687c ^@ http://purl.uniprot.org/uniprot/P9WGE1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ Anti-sigma-F factor antagonist RsfB|||No longer interacts with RsbW.|||Phosphoserine|||STAS|||Still interacts with RsbW. ^@ http://purl.uniprot.org/annotation/PRO_0000422956 http://togogenome.org/gene/83332:Rv0195 ^@ http://purl.uniprot.org/uniprot/O53646 ^@ Region ^@ Domain Extent ^@ HTH luxR-type ^@ http://togogenome.org/gene/83332:Rv3312c ^@ http://purl.uniprot.org/uniprot/O53363 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv1954c ^@ http://purl.uniprot.org/uniprot/P9WLQ3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1954c ^@ http://purl.uniprot.org/annotation/PRO_0000103915 http://togogenome.org/gene/83332:Rv3123 ^@ http://purl.uniprot.org/uniprot/O07034 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0021c ^@ http://purl.uniprot.org/uniprot/P71591 ^@ Region ^@ Domain Extent ^@ NMO ^@ http://togogenome.org/gene/83332:Rv3463 ^@ http://purl.uniprot.org/uniprot/I6X7D4 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv1808 ^@ http://purl.uniprot.org/uniprot/P9WI05 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE32 ^@ http://purl.uniprot.org/annotation/PRO_0000379112 http://togogenome.org/gene/83332:Rv0678 ^@ http://purl.uniprot.org/uniprot/I6Y8F7 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Mutagenesis Site|||Sequence Variant|||Strand|||Turn ^@ Decreases DNA binding.|||H-T-H motif|||HTH marR-type|||HTH-type transcriptional regulator MmpR5|||In CFZ-R1; leads to increased expression of mmpL5 and partial resistance to both clofazimine and bedaquiline. ^@ http://purl.uniprot.org/annotation/PRO_0000432768 http://togogenome.org/gene/83332:Rv2889c ^@ http://purl.uniprot.org/uniprot/P9WNM1 ^@ Molecule Processing ^@ Chain ^@ Elongation factor Ts ^@ http://purl.uniprot.org/annotation/PRO_0000161160 http://togogenome.org/gene/83332:Rv1525 ^@ http://purl.uniprot.org/uniprot/P9WLV3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1525 ^@ http://purl.uniprot.org/annotation/PRO_0000103870 http://togogenome.org/gene/83332:Rv1869c ^@ http://purl.uniprot.org/uniprot/P95146 ^@ Region ^@ Domain Extent ^@ Pyr_redox_2|||Reductase_C ^@ http://togogenome.org/gene/83332:Rv0999 ^@ http://purl.uniprot.org/uniprot/O05582 ^@ Region ^@ Domain Extent ^@ DUF5642 ^@ http://togogenome.org/gene/83332:Rv0644c ^@ http://purl.uniprot.org/uniprot/Q79FX6 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Cyclopropane mycolic acid synthase MmaA2|||N-acetylvaline|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000398359 http://togogenome.org/gene/83332:Rv2351c ^@ http://purl.uniprot.org/uniprot/P9WIB5 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict|||Signal Peptide ^@ Phospholipase C A|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000023942 http://togogenome.org/gene/83332:Rv1349 ^@ http://purl.uniprot.org/uniprot/P9WQJ7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Topological Domain|||Transmembrane ^@ ABC transmembrane type-1|||ABC transporter|||Cytoplasmic|||Helical|||Mycobactin import ATP-binding/permease protein IrtB|||Periplasmic ^@ http://purl.uniprot.org/annotation/PRO_0000093257 http://togogenome.org/gene/83332:Rv0821c ^@ http://purl.uniprot.org/uniprot/P9WI95 ^@ Molecule Processing ^@ Chain ^@ Phosphate-specific transport system accessory protein PhoU homolog 2 ^@ http://purl.uniprot.org/annotation/PRO_0000155173 http://togogenome.org/gene/83332:Rv2534c ^@ http://purl.uniprot.org/uniprot/P9WNM3 ^@ Molecule Processing ^@ Chain ^@ Elongation factor P ^@ http://purl.uniprot.org/annotation/PRO_0000094292 http://togogenome.org/gene/83332:Rv1315 ^@ http://purl.uniprot.org/uniprot/P9WJM1 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Proton donor|||UDP-N-acetylglucosamine 1-carboxyvinyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000178890 http://togogenome.org/gene/83332:Rv2181 ^@ http://purl.uniprot.org/uniprot/P9WMZ9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000393740 http://togogenome.org/gene/83332:Rv2500c ^@ http://purl.uniprot.org/uniprot/I6Y0W5 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv0284 ^@ http://purl.uniprot.org/uniprot/P9WNA9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Transmembrane|||Turn ^@ ESX-3 secretion system protein EccC3|||FtsK 1|||FtsK 2|||FtsK 3|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393430 http://togogenome.org/gene/83332:Rv0978c ^@ http://purl.uniprot.org/uniprot/Q79FU2 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Repeat ^@ NHL 1|||NHL 2|||NHL 3|||PE|||PE-PGRS family protein PE_PGRS17 ^@ http://purl.uniprot.org/annotation/PRO_5007710445 http://togogenome.org/gene/83332:Rv3000 ^@ http://purl.uniprot.org/uniprot/I6X5Z8 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transporter|||Helical ^@ http://togogenome.org/gene/83332:Rv0684 ^@ http://purl.uniprot.org/uniprot/P9WNM7 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Domain Extent|||Helix|||Strand|||Turn ^@ Elongation factor G|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||tr-type G ^@ http://purl.uniprot.org/annotation/PRO_0000091165 http://togogenome.org/gene/83332:Rv3652 ^@ http://purl.uniprot.org/uniprot/Q6MWV1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS60 ^@ http://purl.uniprot.org/annotation/PRO_0000438130 http://togogenome.org/gene/83332:Rv2834c ^@ http://purl.uniprot.org/uniprot/I6Y1U3 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv3149 ^@ http://purl.uniprot.org/uniprot/P9WIV5 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink|||Initiator Methionine|||Modified Residue ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylthreonine|||NADH-quinone oxidoreductase subunit E|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000118696 http://togogenome.org/gene/83332:Rv0945 ^@ http://purl.uniprot.org/uniprot/P9WGR7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv0945 ^@ http://purl.uniprot.org/annotation/PRO_0000054862 http://togogenome.org/gene/83332:Rv0043c ^@ http://purl.uniprot.org/uniprot/P9WMG9 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH gntR-type|||Uncharacterized HTH-type transcriptional regulator Rv0043c ^@ http://purl.uniprot.org/annotation/PRO_0000050695 http://togogenome.org/gene/83332:Rv2970c ^@ http://purl.uniprot.org/uniprot/P95125 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ Carboxylic ester hydrolase LipN|||Loss of activity.|||No change in activity. ^@ http://purl.uniprot.org/annotation/PRO_0000448853 http://togogenome.org/gene/83332:Rv3518c ^@ http://purl.uniprot.org/uniprot/P9WPL5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Steroid C26-monooxygenase|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052304 http://togogenome.org/gene/83332:Rv3479 ^@ http://purl.uniprot.org/uniprot/O06342 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Motif|||Transmembrane ^@ DGA/G|||GXSXG|||Helical|||Nucleophile|||PNPLA|||Proton acceptor|||Uncharacterized membrane protein Rv3479 ^@ http://purl.uniprot.org/annotation/PRO_0000432522 http://togogenome.org/gene/83332:Rv1056 ^@ http://purl.uniprot.org/uniprot/O53404 ^@ Region ^@ Domain Extent ^@ NTP_transf_9 ^@ http://togogenome.org/gene/83332:Rv2445c ^@ http://purl.uniprot.org/uniprot/P9WJH7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Nucleoside diphosphate kinase|||Pros-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000137010 http://togogenome.org/gene/83332:Rv0517 ^@ http://purl.uniprot.org/uniprot/O33362 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Acyl_transf_3|||Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0166 ^@ http://purl.uniprot.org/uniprot/O07411 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv1879 ^@ http://purl.uniprot.org/uniprot/O07751 ^@ Region ^@ Domain Extent ^@ Amidohydro-rel ^@ http://togogenome.org/gene/83332:Rv1345 ^@ http://purl.uniprot.org/uniprot/P9WQ41 ^@ Molecule Processing ^@ Chain ^@ Medium/long-chain-fatty-acid--[acyl-carrier-protein] ligase MbtM ^@ http://purl.uniprot.org/annotation/PRO_0000193141 http://togogenome.org/gene/83332:Rv3087 ^@ http://purl.uniprot.org/uniprot/P9WKB1 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv3087 ^@ http://purl.uniprot.org/annotation/PRO_0000222913 http://togogenome.org/gene/83332:Rv0344c ^@ http://purl.uniprot.org/uniprot/O06295 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide ^@ Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5010230426 http://togogenome.org/gene/83332:Rv1183 ^@ http://purl.uniprot.org/uniprot/P9WJU1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Acyltrehalose exporter MmpL10|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000103574 http://togogenome.org/gene/83332:Rv2018 ^@ http://purl.uniprot.org/uniprot/O53464 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Putative antitoxin VapB45 ^@ http://purl.uniprot.org/annotation/PRO_0000433058 http://togogenome.org/gene/83332:Rv3781 ^@ http://purl.uniprot.org/uniprot/P72047 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv1850 ^@ http://purl.uniprot.org/uniprot/P9WFF1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue|||Sequence Conflict ^@ N6-carboxylysine|||Proton donor|||Removed|||Urease|||Urease subunit alpha|||via carbamate group ^@ http://purl.uniprot.org/annotation/PRO_0000067549 http://togogenome.org/gene/83332:Rv2674 ^@ http://purl.uniprot.org/uniprot/I6YA00 ^@ Region ^@ Domain Extent ^@ MsrB ^@ http://togogenome.org/gene/83332:Rv3510c ^@ http://purl.uniprot.org/uniprot/I6Y3Q7 ^@ Region ^@ Domain Extent ^@ Amidohydro-rel ^@ http://togogenome.org/gene/83332:Rv0739 ^@ http://purl.uniprot.org/uniprot/P9WKS1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0739 ^@ http://purl.uniprot.org/annotation/PRO_0000103716 http://togogenome.org/gene/83332:Rv2139 ^@ http://purl.uniprot.org/uniprot/P9WHL1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Dihydroorotate dehydrogenase (quinone)|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000148457 http://togogenome.org/gene/83332:Rv2504c ^@ http://purl.uniprot.org/uniprot/P9WPW5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A ^@ http://purl.uniprot.org/annotation/PRO_0000157911 http://togogenome.org/gene/83332:Rv3697c ^@ http://purl.uniprot.org/uniprot/P9WF47 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC48 ^@ http://purl.uniprot.org/annotation/PRO_0000407899 http://togogenome.org/gene/83332:Rv3324c ^@ http://purl.uniprot.org/uniprot/P9WJR5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Cyclic pyranopterin monophosphate synthase 3 ^@ http://purl.uniprot.org/annotation/PRO_0000097814 http://togogenome.org/gene/83332:Rv0205 ^@ http://purl.uniprot.org/uniprot/P9WFM5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Putative transport protein Rv0205 ^@ http://purl.uniprot.org/annotation/PRO_0000148317 http://togogenome.org/gene/83332:Rv1964 ^@ http://purl.uniprot.org/uniprot/O53965 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0742 ^@ http://purl.uniprot.org/uniprot/I6Y8K5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS8 ^@ http://purl.uniprot.org/annotation/PRO_5008166656 http://togogenome.org/gene/83332:Rv0032 ^@ http://purl.uniprot.org/uniprot/P9WQ85 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Putative 8-amino-7-oxononanoate synthase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000420959 http://togogenome.org/gene/83332:Rv1966 ^@ http://purl.uniprot.org/uniprot/L7N698 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv0867c ^@ http://purl.uniprot.org/uniprot/P9WG31 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Repeat|||Signal Peptide ^@ 1|||10|||11|||12|||2|||3|||4|||5|||6|||7|||8|||9|||Pro residues|||Resuscitation-promoting factor RpfA ^@ http://purl.uniprot.org/annotation/PRO_0000421025 http://togogenome.org/gene/83332:Rv2900c ^@ http://purl.uniprot.org/uniprot/P9WJP9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized oxidoreductase Rv2900c ^@ http://purl.uniprot.org/annotation/PRO_0000063243 http://togogenome.org/gene/83332:Rv1010 ^@ http://purl.uniprot.org/uniprot/P9WH07 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribosomal RNA small subunit methyltransferase A ^@ http://purl.uniprot.org/annotation/PRO_0000101568 http://togogenome.org/gene/83332:Rv1193 ^@ http://purl.uniprot.org/uniprot/O05295 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv2367c ^@ http://purl.uniprot.org/uniprot/P9WGX9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Endoribonuclease YbeY ^@ http://purl.uniprot.org/annotation/PRO_0000102494 http://togogenome.org/gene/83332:Rv1359 ^@ http://purl.uniprot.org/uniprot/P9WM05 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1359 ^@ http://purl.uniprot.org/annotation/PRO_0000103830 http://togogenome.org/gene/83332:Rv1326c ^@ http://purl.uniprot.org/uniprot/P9WN45 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Helix|||Strand|||Turn ^@ 1,4-alpha-glucan branching enzyme GlgB|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000188718 http://togogenome.org/gene/83332:Rv2191 ^@ http://purl.uniprot.org/uniprot/P9WLJ1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Exonuclease|||GIY-YIG|||Putative bifunctional exonuclease/endonuclease protein Rv2191 ^@ http://purl.uniprot.org/annotation/PRO_0000103970 http://togogenome.org/gene/83332:Rv1068c ^@ http://purl.uniprot.org/uniprot/P9WIF9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ PE|||Polar residues|||Uncharacterized PE-PGRS family protein PE_PGRS20 ^@ http://purl.uniprot.org/annotation/PRO_0000216163 http://togogenome.org/gene/83332:Rv3011c ^@ http://purl.uniprot.org/uniprot/P9WQA1 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-ester intermediate|||Charge relay system|||Glutamyl-tRNA(Gln) amidotransferase subunit A ^@ http://purl.uniprot.org/annotation/PRO_0000105181 http://togogenome.org/gene/83332:Rv1653 ^@ http://purl.uniprot.org/uniprot/P9WPZ3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand ^@ Arginine biosynthesis bifunctional protein ArgJ alpha chain|||Arginine biosynthesis bifunctional protein ArgJ beta chain|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000002193|||http://purl.uniprot.org/annotation/PRO_0000002194 http://togogenome.org/gene/83332:Rv3782 ^@ http://purl.uniprot.org/uniprot/P9WMX3 ^@ Molecule Processing ^@ Chain ^@ Galactofuranosyltransferase GlfT1 ^@ http://purl.uniprot.org/annotation/PRO_0000395355 http://togogenome.org/gene/83332:Rv1987 ^@ http://purl.uniprot.org/uniprot/P9WLQ1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ CBM2|||Uncharacterized protein Rv1987 ^@ http://purl.uniprot.org/annotation/PRO_0000014114 http://togogenome.org/gene/83332:Rv2844 ^@ http://purl.uniprot.org/uniprot/I6Y1V1 ^@ Region ^@ Domain Extent ^@ DUF4439 ^@ http://togogenome.org/gene/83332:Rv3707c ^@ http://purl.uniprot.org/uniprot/I6Y4C4 ^@ Region ^@ Domain Extent ^@ DUF4185 ^@ http://togogenome.org/gene/83332:Rv0957 ^@ http://purl.uniprot.org/uniprot/P9WHM7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Bifunctional purine biosynthesis protein PurH|||MGS-like ^@ http://purl.uniprot.org/annotation/PRO_0000192106 http://togogenome.org/gene/83332:Rv3160c ^@ http://purl.uniprot.org/uniprot/O53310 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2980 ^@ http://purl.uniprot.org/uniprot/P95115 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1622c ^@ http://purl.uniprot.org/uniprot/O06139 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0390 ^@ http://purl.uniprot.org/uniprot/P95198 ^@ Region ^@ Domain Extent ^@ Rhodanese ^@ http://togogenome.org/gene/83332:Rv0351 ^@ http://purl.uniprot.org/uniprot/P9WMT5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue|||Sequence Conflict ^@ Basic and acidic residues|||N-acetylthreonine|||Polar residues|||Protein GrpE|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000113824 http://togogenome.org/gene/83332:Rv3826 ^@ http://purl.uniprot.org/uniprot/P9WQ47 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Long-chain-fatty-acid--AMP ligase FadD23 ^@ http://purl.uniprot.org/annotation/PRO_0000406793 http://togogenome.org/gene/83332:Rv1061 ^@ http://purl.uniprot.org/uniprot/O53409 ^@ Region ^@ Domain Extent ^@ Glutamine amidotransferase type-2 ^@ http://togogenome.org/gene/83332:Rv0531 ^@ http://purl.uniprot.org/uniprot/O06397 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0177 ^@ http://purl.uniprot.org/uniprot/O07421 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1020 ^@ http://purl.uniprot.org/uniprot/P9WMQ5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ DEEQ box|||Helicase ATP-binding|||Helicase C-terminal|||Transcription-repair-coupling factor ^@ http://purl.uniprot.org/annotation/PRO_0000102170 http://togogenome.org/gene/83332:Rv1355c ^@ http://purl.uniprot.org/uniprot/P9WM11 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1355c ^@ http://purl.uniprot.org/annotation/PRO_0000103825 http://togogenome.org/gene/83332:Rv3657c ^@ http://purl.uniprot.org/uniprot/O69625 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||T2SSF ^@ http://togogenome.org/gene/83332:Rv0847 ^@ http://purl.uniprot.org/uniprot/O53859 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ Lipoprotein LpqS|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000433100 http://togogenome.org/gene/83332:Rv2029c ^@ http://purl.uniprot.org/uniprot/P9WID3 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink|||Initiator Methionine|||Modified Residue ^@ ATP-dependent 6-phosphofructokinase isozyme 2|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylthreonine|||Removed|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000392912 http://togogenome.org/gene/83332:Rv3793 ^@ http://purl.uniprot.org/uniprot/P9WNL5 ^@ Molecule Processing|||Natural Variation|||Region|||Secondary Structure ^@ Chain|||Helix|||Sequence Variant|||Strand|||Transmembrane|||Turn ^@ Helical|||Probable arabinosyltransferase C|||Resistance to EMB. ^@ http://purl.uniprot.org/annotation/PRO_0000220573 http://togogenome.org/gene/83332:Rv2544 ^@ http://purl.uniprot.org/uniprot/P9WK79 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppB|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000361671 http://togogenome.org/gene/83332:Rv1861 ^@ http://purl.uniprot.org/uniprot/P95154 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2687c ^@ http://purl.uniprot.org/uniprot/P9WJB1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Fluoroquinolones export permease protein Rv2687c|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000390880 http://togogenome.org/gene/83332:Rv2331 ^@ http://purl.uniprot.org/uniprot/P9WLB3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2331 ^@ http://purl.uniprot.org/annotation/PRO_0000104030 http://togogenome.org/gene/83332:Rv0967 ^@ http://purl.uniprot.org/uniprot/P9WP49 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Turn ^@ Copper-sensing transcriptional repressor CsoR|||Decrease in ability to dissociate from DNA in the presence of copper.|||Loss of ability to bind copper; loss of ability to dissociate from DNA in the presence of copper.|||Loss of ability to bind to DNA; when associated with A-15 and A-36.|||Loss of ability to bind to DNA; when associated with A-15 and A-52.|||Loss of ability to bind to DNA; when associated with A-36 and A-52.|||No effect in ability to bind copper.|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000295581 http://togogenome.org/gene/83332:Rv0753c ^@ http://purl.uniprot.org/uniprot/O53816 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Aldedh ^@ http://togogenome.org/gene/83332:Rv2150c ^@ http://purl.uniprot.org/uniprot/P9WN95 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Cell division protein FtsZ|||Decrease in GTPase activity.|||Reduces FtsZ polymerization and GTP hydrolysis. Does not affect the structure or the stability of the unpolymerized FtsZ.|||Strong decrease in GTPase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000114365 http://togogenome.org/gene/83332:Rv1975 ^@ http://purl.uniprot.org/uniprot/O53976 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ SCP|||SCP domain-containing protein ^@ http://purl.uniprot.org/annotation/PRO_5030174837 http://togogenome.org/gene/83332:Rv0824c ^@ http://purl.uniprot.org/uniprot/P9WNZ7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Putative acyl-[acyl-carrier-protein] desaturase DesA1 ^@ http://purl.uniprot.org/annotation/PRO_0000392675 http://togogenome.org/gene/83332:Rv2804c ^@ http://purl.uniprot.org/uniprot/I6YEE9 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues|||Basic residues|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0048c ^@ http://purl.uniprot.org/uniprot/P9WM87 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0048c ^@ http://purl.uniprot.org/annotation/PRO_0000014065 http://togogenome.org/gene/83332:Rv0879c ^@ http://purl.uniprot.org/uniprot/P9WKR1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0879c ^@ http://purl.uniprot.org/annotation/PRO_0000103723 http://togogenome.org/gene/83332:Rv2631 ^@ http://purl.uniprot.org/uniprot/P9WGW5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ GMP-histidine intermediate|||RNA-splicing ligase RtcB ^@ http://purl.uniprot.org/annotation/PRO_0000215111 http://togogenome.org/gene/83332:Rv3484 ^@ http://purl.uniprot.org/uniprot/O06347 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Helical|||LytR_C|||LytR_cpsA_psr|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1725c ^@ http://purl.uniprot.org/uniprot/P71983 ^@ Region ^@ Domain Extent ^@ HTH hxlR-type ^@ http://togogenome.org/gene/83332:Rv1545 ^@ http://purl.uniprot.org/uniprot/P9WLU9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1545 ^@ http://purl.uniprot.org/annotation/PRO_0000103874 http://togogenome.org/gene/83332:Rv2206 ^@ http://purl.uniprot.org/uniprot/P9WLI5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Polar residues|||Uncharacterized protein Rv2206 ^@ http://purl.uniprot.org/annotation/PRO_0000103974 http://togogenome.org/gene/83332:Rv3025c ^@ http://purl.uniprot.org/uniprot/P9WQ71 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Cysteine persulfide intermediate|||IscS-like cysteine desulfurase|||N6-(pyridoxal phosphate)lysine|||via persulfide group ^@ http://purl.uniprot.org/annotation/PRO_0000420404 http://togogenome.org/gene/83332:Rv1663 ^@ http://purl.uniprot.org/uniprot/O06585 ^@ Region ^@ Domain Extent ^@ Carrier ^@ http://togogenome.org/gene/83332:Rv3208 ^@ http://purl.uniprot.org/uniprot/O05858 ^@ Region ^@ Compositionally Biased Region|||DNA Binding|||Domain Extent ^@ Basic and acidic residues|||H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1997 ^@ http://purl.uniprot.org/uniprot/P9WPS9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Helical|||Probable cation-transporting ATPase F ^@ http://purl.uniprot.org/annotation/PRO_0000046343 http://togogenome.org/gene/83332:Rv3717 ^@ http://purl.uniprot.org/uniprot/I6Y4D2 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Disulfide Bond|||Domain Extent|||Mutagenesis Site|||Signal Peptide ^@ Loss of catalytic activity.|||MurNAc-LAA|||N-acetylmuramoyl-L-alanine amidase Rv3717|||Polar residues|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_5004159884 http://togogenome.org/gene/83332:Rv3170 ^@ http://purl.uniprot.org/uniprot/P9WQ15 ^@ Molecule Processing ^@ Chain ^@ Putative flavin-containing monoamine oxidase AofH ^@ http://purl.uniprot.org/annotation/PRO_0000099867 http://togogenome.org/gene/83332:Rv1495 ^@ http://purl.uniprot.org/uniprot/P9WII5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Endoribonuclease MazF4 ^@ http://purl.uniprot.org/annotation/PRO_0000201902 http://togogenome.org/gene/83332:Rv3542c ^@ http://purl.uniprot.org/uniprot/I6YGF8 ^@ Molecule Processing ^@ Chain ^@ 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase alpha subunit ^@ http://purl.uniprot.org/annotation/PRO_0000452241 http://togogenome.org/gene/83332:Rv1633 ^@ http://purl.uniprot.org/uniprot/P9WFC7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ Beta-hairpin|||Helicase ATP-binding|||Helicase C-terminal|||UVR|||UvrABC system protein B ^@ http://purl.uniprot.org/annotation/PRO_0000138412 http://togogenome.org/gene/83332:Rv0400c ^@ http://purl.uniprot.org/uniprot/P95208 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv0709 ^@ http://purl.uniprot.org/uniprot/P9WHA7 ^@ Molecule Processing ^@ Chain|||Initiator Methionine ^@ 50S ribosomal protein L29|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000130424 http://togogenome.org/gene/83332:Rv1030 ^@ http://purl.uniprot.org/uniprot/P9WPU3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Helical|||Potassium-transporting ATPase ATP-binding subunit ^@ http://purl.uniprot.org/annotation/PRO_0000046126 http://togogenome.org/gene/83332:Rv1901 ^@ http://purl.uniprot.org/uniprot/P9WPE3 ^@ Molecule Processing ^@ Chain ^@ CinA-like protein ^@ http://purl.uniprot.org/annotation/PRO_0000156770 http://togogenome.org/gene/83332:Rv3668c ^@ http://purl.uniprot.org/uniprot/I6YGW2 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010281220 http://togogenome.org/gene/83332:Rv0368c ^@ http://purl.uniprot.org/uniprot/O53703 ^@ Region ^@ Domain Extent ^@ VWFA ^@ http://togogenome.org/gene/83332:Rv0859 ^@ http://purl.uniprot.org/uniprot/O53871 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Crosslink|||Helix|||Strand|||Turn ^@ Acyl-thioester intermediate|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Proton acceptor|||Putative acyltransferase Rv0859 ^@ http://purl.uniprot.org/annotation/PRO_0000395883 http://togogenome.org/gene/83332:Rv1384 ^@ http://purl.uniprot.org/uniprot/P9WPK3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ ATP-grasp 1|||ATP-grasp 2|||Carbamoyl-phosphate synthase large chain|||MGS-like ^@ http://purl.uniprot.org/annotation/PRO_0000145023 http://togogenome.org/gene/83332:Rv3805c ^@ http://purl.uniprot.org/uniprot/O53582 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Terminal beta-(1->2)-arabinofuranosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000420577 http://togogenome.org/gene/83332:Rv2554c ^@ http://purl.uniprot.org/uniprot/P9WGV7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Strand|||Turn ^@ Basic and acidic residues|||Putative pre-16S rRNA nuclease ^@ http://purl.uniprot.org/annotation/PRO_0000172100 http://togogenome.org/gene/83332:Rv0660c ^@ http://purl.uniprot.org/uniprot/O06779 ^@ Molecule Processing ^@ Chain ^@ Probable antitoxin MazE2 ^@ http://purl.uniprot.org/annotation/PRO_0000406297 http://togogenome.org/gene/83332:Rv1517 ^@ http://purl.uniprot.org/uniprot/P71796 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3220c ^@ http://purl.uniprot.org/uniprot/P9WGL5 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Modified Residue|||Strand ^@ Histidine kinase|||Phosphohistidine; by autocatalysis|||Probable sensor histidine kinase PdtaS ^@ http://purl.uniprot.org/annotation/PRO_0000386596 http://togogenome.org/gene/83332:Rv0486 ^@ http://purl.uniprot.org/uniprot/P9WMY7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ D-inositol 3-phosphate glycosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000080318 http://togogenome.org/gene/83332:Rv2699c ^@ http://purl.uniprot.org/uniprot/I6YA17 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv1331 ^@ http://purl.uniprot.org/uniprot/P9WPC1 ^@ Molecule Processing ^@ Chain ^@ ATP-dependent Clp protease adapter protein ClpS ^@ http://purl.uniprot.org/annotation/PRO_0000215726 http://togogenome.org/gene/83332:Rv2161c ^@ http://purl.uniprot.org/uniprot/O06216 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv2525c ^@ http://purl.uniprot.org/uniprot/I6XEI5 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site|||Signal Peptide ^@ 83% loss of esterase activity.|||Complete loss of esterase activity.|||Putative peptidoglycan hydrolase Rv2525c|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_5003706761 http://togogenome.org/gene/83332:Rv2397c ^@ http://purl.uniprot.org/uniprot/P9WQM1 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ ABC transporter|||N-acetylthreonine|||Removed|||Sulfate/thiosulfate import ATP-binding protein CysA ^@ http://purl.uniprot.org/annotation/PRO_0000092276 http://togogenome.org/gene/83332:Rv1167c ^@ http://purl.uniprot.org/uniprot/O50423 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0924c ^@ http://purl.uniprot.org/uniprot/P9WIZ5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Divalent metal cation transporter MntH|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000212627 http://togogenome.org/gene/83332:Rv3346c ^@ http://purl.uniprot.org/uniprot/O50377 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2817c ^@ http://purl.uniprot.org/uniprot/P9WPJ5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ CRISPR-associated endonuclease Cas1 ^@ http://purl.uniprot.org/annotation/PRO_0000418217 http://togogenome.org/gene/83332:Rv0060 ^@ http://purl.uniprot.org/uniprot/O53605 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ DNA ADP-ribosyl glycohydrolase|||Macro|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000456046 http://togogenome.org/gene/83332:Rv2219A ^@ http://purl.uniprot.org/uniprot/Q79FG7 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||RDD ^@ http://togogenome.org/gene/83332:Rv0553 ^@ http://purl.uniprot.org/uniprot/P9WJP3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Proton donor|||o-succinylbenzoate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000171279 http://togogenome.org/gene/83332:Rv0889c ^@ http://purl.uniprot.org/uniprot/P9WPD3 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Putative citrate synthase 2|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000169949 http://togogenome.org/gene/83332:Rv3164c ^@ http://purl.uniprot.org/uniprot/O53314 ^@ Region ^@ Domain Extent ^@ AAA_3|||AAA_lid_2 ^@ http://togogenome.org/gene/83332:Rv2642 ^@ http://purl.uniprot.org/uniprot/P71941 ^@ Region ^@ Domain Extent ^@ HTH arsR-type ^@ http://togogenome.org/gene/83332:Rv3494c ^@ http://purl.uniprot.org/uniprot/I6YC95 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Helical|||MlaD|||Pro residues ^@ http://togogenome.org/gene/83332:Rv3126c ^@ http://purl.uniprot.org/uniprot/P9WL09 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Uncharacterized protein Rv3126c ^@ http://purl.uniprot.org/annotation/PRO_0000392937 http://togogenome.org/gene/83332:Rv1557 ^@ http://purl.uniprot.org/uniprot/P9WJU9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport protein MmpL6 ^@ http://purl.uniprot.org/annotation/PRO_0000103569 http://togogenome.org/gene/83332:Rv3309c ^@ http://purl.uniprot.org/uniprot/P9WFF3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Uracil phosphoribosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000120858 http://togogenome.org/gene/83332:Rv1385 ^@ http://purl.uniprot.org/uniprot/P9WIU3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Orotidine 5'-phosphate decarboxylase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000134630 http://togogenome.org/gene/83332:Rv2039c ^@ http://purl.uniprot.org/uniprot/O53483 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv2216 ^@ http://purl.uniprot.org/uniprot/P9WGP7 ^@ Molecule Processing ^@ Chain ^@ Epimerase family protein Rv2216 ^@ http://purl.uniprot.org/annotation/PRO_0000162407 http://togogenome.org/gene/83332:Rv0497 ^@ http://purl.uniprot.org/uniprot/P9WKU3 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ Basic and acidic residues|||Helical|||N-acetylthreonine|||Removed|||Uncharacterized protein Rv0497 ^@ http://purl.uniprot.org/annotation/PRO_0000103699 http://togogenome.org/gene/83332:Rv1675c ^@ http://purl.uniprot.org/uniprot/P9WMH5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH crp-type|||HTH-type transcriptional regulator Cmr ^@ http://purl.uniprot.org/annotation/PRO_0000420401 http://togogenome.org/gene/83332:Rv2043c ^@ http://purl.uniprot.org/uniprot/I6XD65 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ 10-fold decrease in enzymatic activity with NAM as substrate, and 21-fold decrease in enzymatic activity with PZA as substrate. The mutant has a low metal ion content.|||100-fold decrease in enzymatic activity with NAM or PZA as substrate. The mutant has a low metal ion content.|||112-fold decrease in enzymatic activity with NAM as substrate, and 164-fold decrease in enzymatic activity with PZA as substrate. The mutant has no detectable iron and manganese.|||2.4-fold decrease in enzymatic activity with NAM or PZA as substrate. No effect on metal ion content.|||3000-fold decrease in enzymatic activity with NAM as substrate, and 410-fold decrease in enzymatic activity with PZA as substrate. The mutant has no detectable iron and manganese.|||5-fold decrease in enzymatic activity with NAM as substrate, and 3-fold decrease in enzymatic activity with PZA as substrate. No effect on metal ion content.|||Loss of enzymatic activity. No effect on metal ion content.|||Nicotinamidase/pyrazinamidase|||Nucleophile|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000438715 http://togogenome.org/gene/83332:Rv2868c ^@ http://purl.uniprot.org/uniprot/P9WKG3 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000190602 http://togogenome.org/gene/83332:Rv2536 ^@ http://purl.uniprot.org/uniprot/P95017 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv3728 ^@ http://purl.uniprot.org/uniprot/O69695 ^@ Region|||Site ^@ Active Site|||Compositionally Biased Region|||Domain Extent|||Motif|||Transmembrane ^@ Cyclic nucleotide-binding|||DGA/G|||GXSXG|||Helical|||MFS|||Nucleophile|||PNPLA|||Pro residues|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv1507c ^@ http://purl.uniprot.org/uniprot/P9WLW5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1507c ^@ http://purl.uniprot.org/annotation/PRO_0000103862 http://togogenome.org/gene/83332:Rv3552 ^@ http://purl.uniprot.org/uniprot/P9WPV9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Cholesterol ring-cleaving hydrolase IpdB subunit ^@ http://purl.uniprot.org/annotation/PRO_0000157931 http://togogenome.org/gene/83332:Rv2519 ^@ http://purl.uniprot.org/uniprot/Q79FD3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010161335 http://togogenome.org/gene/83332:Rv0410c ^@ http://purl.uniprot.org/uniprot/P9WI73 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Repeat|||Strand|||Turn ^@ Decrease in activity.|||Decrease in activity; when associated with A-106; A-109 and A-128.|||Decrease in activity; when associated with A-106; A-109 and A-131.|||Decrease in activity; when associated with A-106; A-128 and A-131.|||Decrease in activity; when associated with A-109; A-128 and A-131.|||Decreases inhibition by AX20017; when associated with S-87.|||Decreases inhibition by AX20017; when associated with S-92.|||Lack of activity.|||Lack of activity; when associated with S-106; S-109 and S-128.|||Lack of activity; when associated with S-106; S-109 and S-131.|||Lack of activity; when associated with S-106; S-128 and S-131.|||Lack of activity; when associated with S-109; S-128 and S-131.|||Lack of phosphorylation. Does not affect kinase activity.|||Phosphothreonine; by autocatalysis|||Polar residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknG|||TPR ^@ http://purl.uniprot.org/annotation/PRO_0000171216 http://togogenome.org/gene/83332:Rv2166c ^@ http://purl.uniprot.org/uniprot/P9WJN9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ SpoVT-AbrB 1|||SpoVT-AbrB 2|||Transcriptional regulator MraZ ^@ http://purl.uniprot.org/annotation/PRO_0000108510 http://togogenome.org/gene/83332:Rv3846 ^@ http://purl.uniprot.org/uniprot/P9WGE7 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Strand|||Turn ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Superoxide dismutase [Fe] ^@ http://purl.uniprot.org/annotation/PRO_0000159990 http://togogenome.org/gene/83332:Rv1084 ^@ http://purl.uniprot.org/uniprot/O53432 ^@ Region ^@ Domain Extent ^@ Thioredox_DsbH ^@ http://togogenome.org/gene/83332:Rv2302 ^@ http://purl.uniprot.org/uniprot/P9WLD5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Uncharacterized protein Rv2302 ^@ http://purl.uniprot.org/annotation/PRO_0000104011 http://togogenome.org/gene/83332:Rv0720 ^@ http://purl.uniprot.org/uniprot/P9WHD1 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L18 ^@ http://purl.uniprot.org/annotation/PRO_0000131305 http://togogenome.org/gene/83332:Rv3678c ^@ http://purl.uniprot.org/uniprot/I6YGW9 ^@ Region ^@ Domain Extent ^@ YjgF_endoribonc ^@ http://togogenome.org/gene/83332:Rv1730c ^@ http://purl.uniprot.org/uniprot/P71988 ^@ Region ^@ Domain Extent ^@ Beta-lactamase ^@ http://togogenome.org/gene/83332:Rv1695 ^@ http://purl.uniprot.org/uniprot/P9WHV7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes catalytic activity.|||It promotes stronger allosteric interactions.|||Lower catalytic efficiency. A perturbation of the allosteric interactions is observed when NAD is used as substrate.|||NAD kinase|||Possesses 30% of the activity compared to the wild-type enzyme. While mutant affects the catalytic efficiency, it does not alter the binding affinity for ATP and poly(P). It causes a decrease in the affinity for NAD and alters the allosteric interactions mediated by the dinucleotide, both in the presence of poly(P) and ATP.|||Proton acceptor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000120635 http://togogenome.org/gene/83332:Rv2566 ^@ http://purl.uniprot.org/uniprot/Q50732 ^@ Region ^@ Domain Extent ^@ TGc ^@ http://togogenome.org/gene/83332:Rv0670 ^@ http://purl.uniprot.org/uniprot/P9WQ13 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Probable endonuclease 4 ^@ http://purl.uniprot.org/annotation/PRO_0000190860 http://togogenome.org/gene/83332:Rv1527c ^@ http://purl.uniprot.org/uniprot/O53901 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Lipid Binding|||Modified Residue|||Signal Peptide ^@ Acyl-ester intermediate; for acyltransferase activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase activity|||Carrier|||For beta-ketoacyl synthase activity|||Ketosynthase family 3 (KS3)|||Mycocerosic acid synthase-like polyketide synthase|||N-palmitoyl cysteine|||O-(pantetheine 4'-phosphoryl)serine|||Proton acceptor; for dehydratase activity|||Proton donor; for dehydratase activity|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000437078 http://togogenome.org/gene/83332:Rv0158 ^@ http://purl.uniprot.org/uniprot/O53641 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2709 ^@ http://purl.uniprot.org/uniprot/I6YA25 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv1024 ^@ http://purl.uniprot.org/uniprot/P96376 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1341 ^@ http://purl.uniprot.org/uniprot/P9WMR7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||dITP/XTP pyrophosphatase ^@ http://purl.uniprot.org/annotation/PRO_0000178197 http://togogenome.org/gene/83332:Rv0990c ^@ http://purl.uniprot.org/uniprot/O05573 ^@ Region ^@ Domain Extent ^@ SAF ^@ http://togogenome.org/gene/83332:Rv2487c ^@ http://purl.uniprot.org/uniprot/I6XEF1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5003706547 http://togogenome.org/gene/83332:Rv1180 ^@ http://purl.uniprot.org/uniprot/A0A089QRB9 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Lipid Binding|||Modified Residue|||Signal Peptide ^@ Acyl-ester intermediate; for acyltransferase activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase activity|||Carrier|||For beta-ketoacyl synthase activity|||Ketosynthase family 3 (KS3)|||Mycolipanoate synthase|||N-palmitoyl cysteine|||O-(pantetheine 4'-phosphoryl)serine|||Proton acceptor; for dehydratase activity|||Proton donor; for dehydratase activity|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000438278 http://togogenome.org/gene/83332:Rv0980c ^@ http://purl.uniprot.org/uniprot/Q79FU0 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Repeat ^@ NHL 1|||NHL 2|||NHL 3|||NHL 4|||PE|||PE-PGRS family protein PE_PGRS18 ^@ http://purl.uniprot.org/annotation/PRO_5008177030 http://togogenome.org/gene/83332:Rv3903c ^@ http://purl.uniprot.org/uniprot/O05442 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 2-fold decrease in glycohydrolase activity. Intermediate cytotoxicity.|||Decreases glycohydrolase activity and cytotoxicity in macrophages.|||Lack of glycohydrolase activity and of cytotoxicity; when associated with K-822.|||Lack of glycohydrolase activity and of cytotoxicity; when associated with N-792.|||N-terminal channel domain|||Outer membrane channel protein CpnT|||Pro residues|||TNT|||Tuberculosis necrotizing toxin|||Unfolded. Lack of glycohydrolase activity. Abolishes toxicity. ^@ http://purl.uniprot.org/annotation/PRO_0000437782|||http://purl.uniprot.org/annotation/PRO_0000437783|||http://purl.uniprot.org/annotation/PRO_0000437784 http://togogenome.org/gene/83332:Rv3866 ^@ http://purl.uniprot.org/uniprot/P96210 ^@ Molecule Processing ^@ Chain ^@ ESX-1 secretion-associated protein EspG1 ^@ http://purl.uniprot.org/annotation/PRO_0000394152 http://togogenome.org/gene/83332:Rv1643 ^@ http://purl.uniprot.org/uniprot/P9WHC5 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L20 ^@ http://purl.uniprot.org/annotation/PRO_0000177190 http://togogenome.org/gene/83332:Rv3358 ^@ http://purl.uniprot.org/uniprot/P9WF09 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand ^@ Proton acceptor|||Proton donor|||Toxin RelK ^@ http://purl.uniprot.org/annotation/PRO_0000216213 http://togogenome.org/gene/83332:Rv2827c ^@ http://purl.uniprot.org/uniprot/P71625 ^@ Region ^@ Domain Extent ^@ AbiEi_1 ^@ http://togogenome.org/gene/83332:Rv0072 ^@ http://purl.uniprot.org/uniprot/P9WG17 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized ABC transporter permease Rv0072 ^@ http://purl.uniprot.org/annotation/PRO_0000395862 http://togogenome.org/gene/83332:Rv0564c ^@ http://purl.uniprot.org/uniprot/P9WN75 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Probable glycerol-3-phosphate dehydrogenase 2 [NAD(P)+]|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000137997 http://togogenome.org/gene/83332:Rv3699 ^@ http://purl.uniprot.org/uniprot/O69667 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv2314c ^@ http://purl.uniprot.org/uniprot/P71898 ^@ Region ^@ Domain Extent ^@ PmbA_TldD_C ^@ http://togogenome.org/gene/83332:Rv2654c ^@ http://purl.uniprot.org/uniprot/P9WJ11 ^@ Molecule Processing ^@ Chain ^@ Antitoxin Rv2654c ^@ http://purl.uniprot.org/annotation/PRO_0000406888 http://togogenome.org/gene/83332:Rv3505 ^@ http://purl.uniprot.org/uniprot/I6Y3Q0 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Acyl-CoA dehydrogenase FadE27 ^@ http://purl.uniprot.org/annotation/PRO_0000438521 http://togogenome.org/gene/83332:Rv3140 ^@ http://purl.uniprot.org/uniprot/P95186 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M ^@ http://togogenome.org/gene/83332:Rv0392c ^@ http://purl.uniprot.org/uniprot/P95200 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Transmembrane ^@ Helical|||Type II NADH:quinone oxidoreductase NdhA ^@ http://purl.uniprot.org/annotation/PRO_0000452728 http://togogenome.org/gene/83332:Rv3319 ^@ http://purl.uniprot.org/uniprot/O53371 ^@ Region ^@ Domain Extent ^@ 4Fe-4S ferredoxin-type ^@ http://togogenome.org/gene/83332:Rv0192 ^@ http://purl.uniprot.org/uniprot/O07436 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||L,D-transpeptidase 4|||Nucleophile|||Pro residues|||Proton donor/acceptor|||YkuD ^@ http://purl.uniprot.org/annotation/PRO_0000430336 http://togogenome.org/gene/83332:Rv0681 ^@ http://purl.uniprot.org/uniprot/O53789 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent|||Initiator Methionine|||Modified Residue|||Mutagenesis Site ^@ Almost completely abolishes phosphorylation by PknH.|||H-T-H motif|||HTH tetR-type|||Phosphothreonine; by PknH|||Removed|||Uncharacterized HTH-type transcriptional regulator Rv0681 ^@ http://purl.uniprot.org/annotation/PRO_0000450669 http://togogenome.org/gene/83332:Rv3817 ^@ http://purl.uniprot.org/uniprot/O07806 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ APH|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2226 ^@ http://purl.uniprot.org/uniprot/P9WLH9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2226 ^@ http://purl.uniprot.org/annotation/PRO_0000103979 http://togogenome.org/gene/83332:Rv0018c ^@ http://purl.uniprot.org/uniprot/P9WHW5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ 60% loss of phosphatase activity.|||90% loss of phosphatase activity.|||Cytoplasmic|||Decreases affinity for Mn3 by 4-fold, no effect on hydrolysis of p-nitrophenyl phosphate.|||Extracellular|||Helical|||No change in activity.|||No change in affinity for Mn3, no effect on hydrolysis of p-nitrophenyl phosphate.|||PPM-type phosphatase|||Phosphothreonine; by PknA and PknB|||Phosphothreonine; by PknB|||Polar residues|||Pro residues|||Serine/threonine protein phosphatase PstP ^@ http://purl.uniprot.org/annotation/PRO_0000344805 http://togogenome.org/gene/83332:Rv0864 ^@ http://purl.uniprot.org/uniprot/P9WJR7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Cyclic pyranopterin monophosphate synthase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000097812 http://togogenome.org/gene/83332:Rv0508 ^@ http://purl.uniprot.org/uniprot/P9WKS9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0508 ^@ http://purl.uniprot.org/annotation/PRO_0000103712 http://togogenome.org/gene/83332:Rv1685c ^@ http://purl.uniprot.org/uniprot/O33187 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2053c ^@ http://purl.uniprot.org/uniprot/O53495 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3448 ^@ http://purl.uniprot.org/uniprot/P9WNQ1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-4 secretion system protein eccD4|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393236 http://togogenome.org/gene/83332:Rv2546 ^@ http://purl.uniprot.org/uniprot/P95007 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC18 ^@ http://purl.uniprot.org/annotation/PRO_0000407877 http://togogenome.org/gene/83332:Rv1087 ^@ http://purl.uniprot.org/uniprot/Q79FT0 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv2873 ^@ http://purl.uniprot.org/uniprot/P9WNF3 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Glycosylation Site|||Lipid Binding|||Signal Peptide ^@ Cell surface glycolipoprotein MPT83|||FAS1|||N-palmitoyl cysteine|||O-linked (Man...) threonine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000008788 http://togogenome.org/gene/83332:Rv2837c ^@ http://purl.uniprot.org/uniprot/P71615 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Bifunctional oligoribonuclease and PAP phosphatase NrnA ^@ http://purl.uniprot.org/annotation/PRO_0000419753 http://togogenome.org/gene/83332:Rv0420c ^@ http://purl.uniprot.org/uniprot/P96266 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0082 ^@ http://purl.uniprot.org/uniprot/I6XUD2 ^@ Region ^@ Domain Extent ^@ Oxidored_q6 ^@ http://togogenome.org/gene/83332:Rv2178c ^@ http://purl.uniprot.org/uniprot/O53512 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mass|||Strand|||Turn ^@ Phospho-2-dehydro-3-deoxyheptonate aldolase AroG ^@ http://purl.uniprot.org/annotation/PRO_0000414909 http://togogenome.org/gene/83332:Rv3856c ^@ http://purl.uniprot.org/uniprot/P96221 ^@ Region ^@ Domain Extent ^@ POLIIIAc ^@ http://togogenome.org/gene/83332:Rv1100 ^@ http://purl.uniprot.org/uniprot/O53448 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2841c ^@ http://purl.uniprot.org/uniprot/P9WIV3 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ KH 1|||KH 2|||S1 motif|||Transcription termination/antitermination protein NusA ^@ http://purl.uniprot.org/annotation/PRO_0000181974 http://togogenome.org/gene/83332:Rv3689 ^@ http://purl.uniprot.org/uniprot/I6YCR8 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv3558 ^@ http://purl.uniprot.org/uniprot/Q6MWW0 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv1740 ^@ http://purl.uniprot.org/uniprot/P9WJ31 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB34 ^@ http://purl.uniprot.org/annotation/PRO_0000413610 http://togogenome.org/gene/83332:Rv1400c ^@ http://purl.uniprot.org/uniprot/P71668 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site ^@ 90% loss of activity.|||Complete loss of activity.|||Esterase LipI ^@ http://purl.uniprot.org/annotation/PRO_0000448851 http://togogenome.org/gene/83332:Rv2576c ^@ http://purl.uniprot.org/uniprot/P9WL83 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2576c ^@ http://purl.uniprot.org/annotation/PRO_0000104058 http://togogenome.org/gene/83332:Rv0028 ^@ http://purl.uniprot.org/uniprot/P9WM97 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Removed|||Uncharacterized protein Rv0028 ^@ http://purl.uniprot.org/annotation/PRO_0000103646 http://togogenome.org/gene/83332:Rv1222 ^@ http://purl.uniprot.org/uniprot/L0T905 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue|||Mutagenesis Site ^@ Anti-sigma-E factor RseA|||Considerably reduced interaction with SigE. Complete loss of interaction; when associated with A-70.|||Considerably reduced interaction with SigE. Complete loss of interaction; when associated with A-73.|||Loss of phosphorylation, no protein degradation.|||No change in interaction with SigE.|||No change in phosphorylation.|||Phosphothreonine; by PknB ^@ http://purl.uniprot.org/annotation/PRO_0000422950 http://togogenome.org/gene/83332:Rv2065 ^@ http://purl.uniprot.org/uniprot/P9WP87 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Precorrin-8X methylmutase|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000135924 http://togogenome.org/gene/83332:Rv1537 ^@ http://purl.uniprot.org/uniprot/P9WNT3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ DNA polymerase IV 1|||UmuC ^@ http://purl.uniprot.org/annotation/PRO_0000173924 http://togogenome.org/gene/83332:Rv0174 ^@ http://purl.uniprot.org/uniprot/L0T2W6 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv1037c ^@ http://purl.uniprot.org/uniprot/P0DOA6|||http://purl.uniprot.org/uniprot/P0DOA7 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ ESAT-6-like protein EsxI|||ESAT-6-like protein EsxV ^@ http://purl.uniprot.org/annotation/PRO_0000167800|||http://purl.uniprot.org/annotation/PRO_0000436928 http://togogenome.org/gene/83332:Rv3244c ^@ http://purl.uniprot.org/uniprot/P9WK37 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ Lipoprotein LpqB|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000286724 http://togogenome.org/gene/83332:Rv0109 ^@ http://purl.uniprot.org/uniprot/L0T2H7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5003947676 http://togogenome.org/gene/83332:Rv1876 ^@ http://purl.uniprot.org/uniprot/P9WPQ9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix ^@ Bacterioferritin BfrA|||Ferritin-like diiron|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000192600 http://togogenome.org/gene/83332:Rv3914 ^@ http://purl.uniprot.org/uniprot/P9WG67 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Disulfide Bond|||Domain Extent|||Helix|||Initiator Methionine|||Strand|||Turn ^@ Redox-active|||Removed|||Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_0000120117 http://togogenome.org/gene/83332:Rv0830 ^@ http://purl.uniprot.org/uniprot/P9WFI3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0830 ^@ http://purl.uniprot.org/annotation/PRO_0000361244 http://togogenome.org/gene/83332:Rv3563 ^@ http://purl.uniprot.org/uniprot/P96845 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv2015c ^@ http://purl.uniprot.org/uniprot/O53461 ^@ Region ^@ Domain Extent ^@ HNHc ^@ http://togogenome.org/gene/83332:Rv1655 ^@ http://purl.uniprot.org/uniprot/P9WPZ7 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Acetylornithine aminotransferase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||N-acetylthreonine; partial|||N6-(pyridoxal phosphate)lysine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000112756 http://togogenome.org/gene/83332:Rv3369 ^@ http://purl.uniprot.org/uniprot/O50398 ^@ Region ^@ Domain Extent ^@ Putative_PNPOx ^@ http://togogenome.org/gene/83332:Rv1847 ^@ http://purl.uniprot.org/uniprot/P9WIM3 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Putative esterase Rv1847 ^@ http://purl.uniprot.org/annotation/PRO_0000156683 http://togogenome.org/gene/83332:Rv3189 ^@ http://purl.uniprot.org/uniprot/O53335 ^@ Molecule Processing ^@ Chain ^@ Probable NAD(+) phosphorylase Rv3189 ^@ http://purl.uniprot.org/annotation/PRO_0000448609 http://togogenome.org/gene/83332:Rv2327 ^@ http://purl.uniprot.org/uniprot/P71885 ^@ Region ^@ Domain Extent ^@ HTH marR-type ^@ http://togogenome.org/gene/83332:Rv3521 ^@ http://purl.uniprot.org/uniprot/O53566 ^@ Region ^@ Domain Extent ^@ OB_aCoA_assoc ^@ http://togogenome.org/gene/83332:Rv1242 ^@ http://purl.uniprot.org/uniprot/P9WF69 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribonuclease VapC33 ^@ http://purl.uniprot.org/annotation/PRO_0000407890 http://togogenome.org/gene/83332:Rv3860 ^@ http://purl.uniprot.org/uniprot/P96217 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||CbiA|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0202c ^@ http://purl.uniprot.org/uniprot/P9WJT9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Strand|||Transmembrane ^@ Helical|||Heme uptake protein MmpL11 ^@ http://purl.uniprot.org/annotation/PRO_0000103577 http://togogenome.org/gene/83332:Rv0692 ^@ http://purl.uniprot.org/uniprot/P95038 ^@ Molecule Processing ^@ Chain ^@ Peptide chaperone MftB ^@ http://purl.uniprot.org/annotation/PRO_0000415283 http://togogenome.org/gene/83332:Rv3828c ^@ http://purl.uniprot.org/uniprot/O07795 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ O-(5'-phospho-DNA)-serine intermediate|||Resolvase/invertase-type recombinase catalytic ^@ http://togogenome.org/gene/83332:Rv1063c ^@ http://purl.uniprot.org/uniprot/P9WIY9 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Motif ^@ DGA/G|||GXSXG|||Nucleophile|||PNPLA|||Proton acceptor|||Uncharacterized NTE family protein Rv1063c ^@ http://purl.uniprot.org/annotation/PRO_0000172534 http://togogenome.org/gene/83332:Rv2237 ^@ http://purl.uniprot.org/uniprot/P9WLH1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2237 ^@ http://purl.uniprot.org/annotation/PRO_0000103985 http://togogenome.org/gene/83332:Rv0875c ^@ http://purl.uniprot.org/uniprot/P9WKR7 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv0875c ^@ http://purl.uniprot.org/annotation/PRO_0000014079 http://togogenome.org/gene/83332:Rv3460c ^@ http://purl.uniprot.org/uniprot/P9WH61 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 30S ribosomal protein S13|||Basic residues ^@ http://purl.uniprot.org/annotation/PRO_0000132114 http://togogenome.org/gene/83332:Rv0696 ^@ http://purl.uniprot.org/uniprot/P9WMX1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Pre-mycofactocin glycosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000415278 http://togogenome.org/gene/83332:Rv1352 ^@ http://purl.uniprot.org/uniprot/P9WM15 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv1352 ^@ http://purl.uniprot.org/annotation/PRO_0000014097 http://togogenome.org/gene/83332:Rv3394c ^@ http://purl.uniprot.org/uniprot/O50419 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ UmuC|||UmuC domain-containing protein ^@ http://purl.uniprot.org/annotation/PRO_5010342987 http://togogenome.org/gene/83332:Rv1190 ^@ http://purl.uniprot.org/uniprot/O86348 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv2886c ^@ http://purl.uniprot.org/uniprot/P9WL35 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ O-(5'-phospho-DNA)-serine intermediate|||Resolvase/invertase-type recombinase catalytic|||Uncharacterized protein Rv2886c ^@ http://purl.uniprot.org/annotation/PRO_0000104091 http://togogenome.org/gene/83332:Rv2363 ^@ http://purl.uniprot.org/uniprot/P9WQ99 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-ester intermediate|||Charge relay system|||Putative amidase AmiA2 ^@ http://purl.uniprot.org/annotation/PRO_0000105253 http://togogenome.org/gene/83332:Rv2744c ^@ http://purl.uniprot.org/uniprot/P9WHP5 ^@ Molecule Processing ^@ Chain ^@ PspA protein ^@ http://purl.uniprot.org/annotation/PRO_0000166290 http://togogenome.org/gene/83332:Rv2847c ^@ http://purl.uniprot.org/uniprot/I6X5I7 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Proton acceptor|||Proton donor|||TP_methylase ^@ http://togogenome.org/gene/83332:Rv0092 ^@ http://purl.uniprot.org/uniprot/P9WPU1 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ 4-aspartylphosphate intermediate|||Copper-exporting P-type ATPase|||HMA|||Helical|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000046165 http://togogenome.org/gene/83332:Rv1857 ^@ http://purl.uniprot.org/uniprot/P9WGU3 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Lipid Binding|||Sequence Conflict|||Signal Peptide ^@ Molybdate-binding protein ModA|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000031831 http://togogenome.org/gene/83332:Rv2188c ^@ http://purl.uniprot.org/uniprot/P9WMZ3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000393733 http://togogenome.org/gene/83332:Rv3019c ^@ http://purl.uniprot.org/uniprot/P9WNI9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ ESAT-6-like protein EsxR ^@ http://purl.uniprot.org/annotation/PRO_0000167813 http://togogenome.org/gene/83332:Rv2676c ^@ http://purl.uniprot.org/uniprot/P9WL45 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink|||Mutagenesis Site ^@ Coproheme decarboxylase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Strong decrease in heme binding.|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000396082 http://togogenome.org/gene/83332:Rv2852c ^@ http://purl.uniprot.org/uniprot/P9WJP5 ^@ Molecule Processing ^@ Chain ^@ Probable malate:quinone oxidoreductase ^@ http://purl.uniprot.org/annotation/PRO_0000128721 http://togogenome.org/gene/83332:Rv3621c ^@ http://purl.uniprot.org/uniprot/P9WHX3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE65 ^@ http://purl.uniprot.org/annotation/PRO_0000378487 http://togogenome.org/gene/83332:Rv0212c ^@ http://purl.uniprot.org/uniprot/P96394 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ AAA_28 ^@ http://togogenome.org/gene/83332:Rv3333c ^@ http://purl.uniprot.org/uniprot/O53383 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ DUF732|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5010186603 http://togogenome.org/gene/83332:Rv0579 ^@ http://purl.uniprot.org/uniprot/O53776 ^@ Region ^@ Domain Extent ^@ Mut7-C|||Ub-Mut7C ^@ http://togogenome.org/gene/83332:Rv3146 ^@ http://purl.uniprot.org/uniprot/P9WJH1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ NADH-quinone oxidoreductase subunit B ^@ http://purl.uniprot.org/annotation/PRO_0000118773 http://togogenome.org/gene/83332:Rv1750c ^@ http://purl.uniprot.org/uniprot/P72007 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv0040c ^@ http://purl.uniprot.org/uniprot/P9WIM9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Signal Peptide|||Strand|||Turn ^@ Pro residues|||Proline-rich 28 kDa antigen ^@ http://purl.uniprot.org/annotation/PRO_0000022094 http://togogenome.org/gene/83332:Rv2247 ^@ http://purl.uniprot.org/uniprot/P9WQH5 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit|||CoA carboxyltransferase C-terminal|||CoA carboxyltransferase N-terminal|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000199800 http://togogenome.org/gene/83332:Rv1232c ^@ http://purl.uniprot.org/uniprot/O86315 ^@ Region ^@ Domain Extent ^@ CBS ^@ http://togogenome.org/gene/83332:Rv2075c ^@ http://purl.uniprot.org/uniprot/P9WLL5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2075c ^@ http://purl.uniprot.org/annotation/PRO_0000103946 http://togogenome.org/gene/83332:Rv0184 ^@ http://purl.uniprot.org/uniprot/O07428 ^@ Region ^@ Domain Extent ^@ DUF2786 ^@ http://togogenome.org/gene/83332:Rv3254 ^@ http://purl.uniprot.org/uniprot/O05897 ^@ Molecule Processing ^@ Chain|||Propeptide ^@ Protein Rv3254 ^@ http://purl.uniprot.org/annotation/PRO_0000432521|||http://purl.uniprot.org/annotation/PRO_0000455444 http://togogenome.org/gene/83332:Rv0164 ^@ http://purl.uniprot.org/uniprot/L7N657 ^@ Region ^@ Domain Extent ^@ Polyketide_cyc ^@ http://togogenome.org/gene/83332:Rv1886c ^@ http://purl.uniprot.org/uniprot/P9WQP1 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond|||Helix|||Signal Peptide|||Strand|||Turn ^@ Diacylglycerol acyltransferase/mycolyltransferase Ag85B|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000000222 http://togogenome.org/gene/83332:Rv2376c ^@ http://purl.uniprot.org/uniprot/P9WIN7 ^@ Molecule Processing ^@ Chain|||Propeptide|||Signal Peptide ^@ Low molecular weight antigen MTB12 ^@ http://purl.uniprot.org/annotation/PRO_0000021777|||http://purl.uniprot.org/annotation/PRO_0000021778 http://togogenome.org/gene/83332:Rv0844c ^@ http://purl.uniprot.org/uniprot/P9WGM5 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand ^@ 4-aspartylphosphate|||Complete loss of phosphorylation.|||H-T-H motif|||HTH luxR-type|||Probable transcriptional regulatory protein NarL|||Response regulatory ^@ http://purl.uniprot.org/annotation/PRO_0000401134 http://togogenome.org/gene/83332:Rv1699 ^@ http://purl.uniprot.org/uniprot/P9WHK7 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 14-fold reduction in catalytic activity. 10-fold decrease in affinity for ATP but no change in affinity for UTP. Causes resistance to the anti-tubercular compounds 7947882 and 7904688. Catalytic activity cannot be inhibited by the active metabolite of 7947882.|||CTP synthase|||Glutamine amidotransferase type-1|||Nucleophile; for glutamine hydrolysis ^@ http://purl.uniprot.org/annotation/PRO_0000138202 http://togogenome.org/gene/83332:Rv2551c ^@ http://purl.uniprot.org/uniprot/I6Y9M6 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Peptidase_A24 ^@ http://togogenome.org/gene/83332:Rv2026c ^@ http://purl.uniprot.org/uniprot/P9WFD1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Universal stress protein Rv2026c ^@ http://purl.uniprot.org/annotation/PRO_0000396946 http://togogenome.org/gene/83332:Rv2198c ^@ http://purl.uniprot.org/uniprot/P9WJT1 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue|||Transmembrane ^@ Basic and acidic residues|||Helical|||N-acetylserine|||Polar residues|||Pro residues|||Probable transport accessory protein MmpS3|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000216155 http://togogenome.org/gene/83332:Rv1665 ^@ http://purl.uniprot.org/uniprot/P9WPF3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Can catalyze the hydrolysis of palmitoyl-CoA, but cannot produce cyclic polyketide products.|||Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000407318 http://togogenome.org/gene/83332:Rv3383c ^@ http://purl.uniprot.org/uniprot/O50410 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ DDXXD motif|||Geranylgeranyl diphosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000451296 http://togogenome.org/gene/83332:Rv1110 ^@ http://purl.uniprot.org/uniprot/P9WKG1 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000128841 http://togogenome.org/gene/83332:Rv2339 ^@ http://purl.uniprot.org/uniprot/P9WJU3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport protein MmpL9 ^@ http://purl.uniprot.org/annotation/PRO_0000103573 http://togogenome.org/gene/83332:Rv3199c ^@ http://purl.uniprot.org/uniprot/P9WIX5 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Motif ^@ NAD-capped RNA hydrolase NudC|||Nudix box|||Nudix hydrolase ^@ http://purl.uniprot.org/annotation/PRO_0000056970 http://togogenome.org/gene/83332:Rv3872 ^@ http://purl.uniprot.org/uniprot/P9WIG7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE family immunomodulator PE35 ^@ http://purl.uniprot.org/annotation/PRO_0000394202 http://togogenome.org/gene/83332:Rv1113 ^@ http://purl.uniprot.org/uniprot/P9WJ33 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB32 ^@ http://purl.uniprot.org/annotation/PRO_0000408076 http://togogenome.org/gene/83332:Rv1253 ^@ http://purl.uniprot.org/uniprot/P9WH05 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Motif ^@ ATP-dependent RNA helicase DeaD|||Basic and acidic residues|||DEAD box|||Helicase ATP-binding|||Helicase C-terminal|||Q motif ^@ http://purl.uniprot.org/annotation/PRO_0000055106 http://togogenome.org/gene/83332:Rv0878c ^@ http://purl.uniprot.org/uniprot/P9WI35 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized PPE family protein PPE13 ^@ http://purl.uniprot.org/annotation/PRO_0000217844 http://togogenome.org/gene/83332:Rv2987c ^@ http://purl.uniprot.org/uniprot/P9WK95 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Crosslink|||Helix|||Strand|||Turn ^@ 3-isopropylmalate dehydratase small subunit|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000141840 http://togogenome.org/gene/83332:Rv0736 ^@ http://purl.uniprot.org/uniprot/P9WJ67 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Topological Domain|||Transmembrane ^@ Anti-sigma-L factor RslA|||Cytoplasmic|||Extracellular|||Helical|||Loss of Zn(2+)-binding.|||No change in Zn(2+)-binding. ^@ http://purl.uniprot.org/annotation/PRO_0000422682 http://togogenome.org/gene/83332:Rv3870 ^@ http://purl.uniprot.org/uniprot/P9WNB3 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Mutagenesis Site|||Transmembrane ^@ Cells unable to export EsxB, missing transmembrane domain.|||Cells unable to export EsxB.|||Decreased export of EsxB.|||ESX-1 secretion system protein EccCa1|||FtsK|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393428 http://togogenome.org/gene/83332:Rv1075c ^@ http://purl.uniprot.org/uniprot/O53423 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site|||Signal Peptide ^@ GDSL-like esterase Rv1075c|||Nucleophile|||Proton acceptor|||Proton donor|||Strong decrease in activity. ^@ http://purl.uniprot.org/annotation/PRO_0000448307 http://togogenome.org/gene/83332:Rv0534c ^@ http://purl.uniprot.org/uniprot/P9WIP3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ 1,4-dihydroxy-2-naphthoate octaprenyltransferase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000096418 http://togogenome.org/gene/83332:Rv1363c ^@ http://purl.uniprot.org/uniprot/P9WLZ9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1363c ^@ http://purl.uniprot.org/annotation/PRO_0000103832 http://togogenome.org/gene/83332:Rv1542c ^@ http://purl.uniprot.org/uniprot/P9WN25 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Turn ^@ Group 1 truncated hemoglobin GlbN|||proximal binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000162640 http://togogenome.org/gene/83332:Rv2036 ^@ http://purl.uniprot.org/uniprot/O53480 ^@ Region ^@ Domain Extent ^@ MDMPI_N ^@ http://togogenome.org/gene/83332:Rv2897c ^@ http://purl.uniprot.org/uniprot/P9WPR1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2897c ^@ http://purl.uniprot.org/annotation/PRO_0000206880 http://togogenome.org/gene/83332:Rv1007c ^@ http://purl.uniprot.org/uniprot/P9WFU5 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Helix|||Motif|||Strand|||Turn ^@ 'HIGH' region|||'KMSKS' region|||Methionine--tRNA ligase|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000139233 http://togogenome.org/gene/83332:Rv2855 ^@ http://purl.uniprot.org/uniprot/P9WHH3 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond ^@ Mycothione reductase|||Proton acceptor|||Redox-active ^@ http://purl.uniprot.org/annotation/PRO_0000399830 http://togogenome.org/gene/83332:Rv3032 ^@ http://purl.uniprot.org/uniprot/P9WMY9 ^@ Molecule Processing ^@ Chain ^@ Glycogen synthase ^@ http://purl.uniprot.org/annotation/PRO_0000413905 http://togogenome.org/gene/83332:Rv3569c ^@ http://purl.uniprot.org/uniprot/P9WNH5 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase|||Proton acceptor|||Reduces the hydrolase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000404509 http://togogenome.org/gene/83332:Rv0763c ^@ http://purl.uniprot.org/uniprot/P71820 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ferredoxin Fdx ^@ http://purl.uniprot.org/annotation/PRO_0000456900 http://togogenome.org/gene/83332:Rv3738c ^@ http://purl.uniprot.org/uniprot/P9WHX1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized PPE family protein PPE66 ^@ http://purl.uniprot.org/annotation/PRO_0000379592 http://togogenome.org/gene/83332:Rv0223c ^@ http://purl.uniprot.org/uniprot/I6X8S7 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Aldedh ^@ http://togogenome.org/gene/83332:Rv0591 ^@ http://purl.uniprot.org/uniprot/O07787 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Mce4_CUP1|||MlaD|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1984c ^@ http://purl.uniprot.org/uniprot/P9WP43 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Mutagenesis Site|||Signal Peptide ^@ 30% decrease in activity with pNP-octanoate and vinyl-caprylate as substrates.|||Carboxylesterase Culp1|||Loss of activity.|||Nucleophile|||Proton donor/acceptor|||Shows a strong preference for substrates with a medium chain length ranging between 6 and 8 carbon atoms. 17-18% increase in activity with VC6 or VC8 as substrates. Aquires phospholipase A activity and shows cytotoxic effects on macrophages.|||Shows a strong preference for substrates with a medium chain length ranging between 6 and 8 carbon atoms. 31% and 25% decrease in activity with 6 carbon atoms vinyl esters (VC6) or 8 carbon atoms vinyl esters (VC8) as substrates. Enhances lipase activity on triglycerides. Aquires phospholipase A activity and shows cytotoxic effects on macrophages.|||Shows a strong preference for substrates with a medium chain length ranging between 6 and 8 carbon atoms. Loses 99% and 80% of activity with VC6 or VC8 as substrates. Loss of lipase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000006447 http://togogenome.org/gene/83332:Rv1767 ^@ http://purl.uniprot.org/uniprot/O06800 ^@ Region ^@ Domain Extent ^@ CMD ^@ http://togogenome.org/gene/83332:Rv3156 ^@ http://purl.uniprot.org/uniprot/P9WIW1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||NADH-quinone oxidoreductase subunit L ^@ http://purl.uniprot.org/annotation/PRO_0000118218 http://togogenome.org/gene/83332:Rv3537 ^@ http://purl.uniprot.org/uniprot/P71864 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 3-oxosteroid 1-dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000403952 http://togogenome.org/gene/83332:Rv0407 ^@ http://purl.uniprot.org/uniprot/P9WNE1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ F420-dependent glucose-6-phosphate dehydrogenase|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000399504 http://togogenome.org/gene/83332:Rv0051 ^@ http://purl.uniprot.org/uniprot/P71708 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv2977c ^@ http://purl.uniprot.org/uniprot/P9WG71 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Thiamine-monophosphate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000415641 http://togogenome.org/gene/83332:Rv0227c ^@ http://purl.uniprot.org/uniprot/P96409 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0886 ^@ http://purl.uniprot.org/uniprot/P9WJI1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ 4Fe-4S ferredoxin-type 1|||4Fe-4S ferredoxin-type 2|||Probable ferredoxin/ferredoxin--NADP reductase ^@ http://purl.uniprot.org/annotation/PRO_0000167676 http://togogenome.org/gene/83332:Rv0194 ^@ http://purl.uniprot.org/uniprot/O53645 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ ABC transmembrane type-1 1|||ABC transmembrane type-1 2|||ABC transporter 1|||ABC transporter 2|||Helical|||Multidrug efflux ATP-binding/permease protein Rv0194 ^@ http://purl.uniprot.org/annotation/PRO_0000432861 http://togogenome.org/gene/83332:Rv0275c ^@ http://purl.uniprot.org/uniprot/L7N6A2 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv0706 ^@ http://purl.uniprot.org/uniprot/P9WHC1 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue ^@ 50S ribosomal protein L22|||Basic and acidic residues|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000125187 http://togogenome.org/gene/83332:Rv2918c ^@ http://purl.uniprot.org/uniprot/P9WN29 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ ACT 1|||ACT 2|||Bifunctional uridylyltransferase/uridylyl-removing enzyme|||HD ^@ http://purl.uniprot.org/annotation/PRO_0000192745 http://togogenome.org/gene/83332:Rv1898 ^@ http://purl.uniprot.org/uniprot/P9WFQ1 ^@ Molecule Processing ^@ Chain ^@ UPF0045 protein Rv1898 ^@ http://purl.uniprot.org/annotation/PRO_0000147623 http://togogenome.org/gene/83332:Rv2388c ^@ http://purl.uniprot.org/uniprot/P9WP73 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Heme chaperone HemW|||Radical SAM core ^@ http://purl.uniprot.org/annotation/PRO_0000109944 http://togogenome.org/gene/83332:Rv2745c ^@ http://purl.uniprot.org/uniprot/P9WMH7 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH cro/C1-type|||Transcriptional regulator ClgR ^@ http://purl.uniprot.org/annotation/PRO_0000423653 http://togogenome.org/gene/83332:Rv1711 ^@ http://purl.uniprot.org/uniprot/P9WHQ1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Nucleophile|||S4 RNA-binding|||Uncharacterized RNA pseudouridine synthase Rv1711 ^@ http://purl.uniprot.org/annotation/PRO_0000100029 http://togogenome.org/gene/83332:Rv0856 ^@ http://purl.uniprot.org/uniprot/O53868 ^@ Region ^@ Domain Extent ^@ Polyketide_cyc ^@ http://togogenome.org/gene/83332:Rv1381 ^@ http://purl.uniprot.org/uniprot/P9WHL3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Dihydroorotase ^@ http://purl.uniprot.org/annotation/PRO_0000147244 http://togogenome.org/gene/83332:Rv2563 ^@ http://purl.uniprot.org/uniprot/P9WG15 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized ABC transporter permease Rv2563 ^@ http://purl.uniprot.org/annotation/PRO_0000014134 http://togogenome.org/gene/83332:Rv2208 ^@ http://purl.uniprot.org/uniprot/P9WP91 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Adenosylcobinamide-GDP ribazoletransferase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000146886 http://togogenome.org/gene/83332:Rv2392 ^@ http://purl.uniprot.org/uniprot/P9WIK3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Adenosine 5'-phosphosulfate reductase|||Nucleophile; cysteine thiosulfonate intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000100633 http://togogenome.org/gene/83332:Rv1196 ^@ http://purl.uniprot.org/uniprot/L7N675 ^@ Molecule Processing ^@ Chain ^@ PPE family protein PPE18 ^@ http://purl.uniprot.org/annotation/PRO_0000438002 http://togogenome.org/gene/83332:Rv2350c ^@ http://purl.uniprot.org/uniprot/P9WIB3 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict|||Signal Peptide ^@ Phospholipase C B|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000023943 http://togogenome.org/gene/83332:Rv2465c ^@ http://purl.uniprot.org/uniprot/P9WKD7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand ^@ Proton acceptor|||Proton donor|||Ribose-5-phosphate isomerase B ^@ http://purl.uniprot.org/annotation/PRO_0000251148 http://togogenome.org/gene/83332:Rv2865 ^@ http://purl.uniprot.org/uniprot/O33347 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Antitoxin RelF ^@ http://purl.uniprot.org/annotation/PRO_0000406202 http://togogenome.org/gene/83332:Rv0977 ^@ http://purl.uniprot.org/uniprot/Q79FU3 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Motif|||Strand|||Turn ^@ D(T/S)G 1|||D(T/S)G 2|||PE|||PE-PGRS family protein PE_PGRS16 ^@ http://purl.uniprot.org/annotation/PRO_0000438172 http://togogenome.org/gene/83332:Rv2999 ^@ http://purl.uniprot.org/uniprot/O53246 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010212198 http://togogenome.org/gene/83332:Rv3883c ^@ http://purl.uniprot.org/uniprot/O05461 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Mutagenesis Site|||Signal Peptide|||Transmembrane ^@ Charge relay system|||Helical|||Lack of protease activity. Has hyperactivated ESX-1 secretion during macrophage infection, resulting in increased innate immune signaling. Secretes full-length EspB.|||Mycosin-1|||Peptidase S8 ^@ http://purl.uniprot.org/annotation/PRO_5007696644 http://togogenome.org/gene/83332:Rv0550c ^@ http://purl.uniprot.org/uniprot/P9WJ59 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB3 ^@ http://purl.uniprot.org/annotation/PRO_0000408053 http://togogenome.org/gene/83332:Rv1415 ^@ http://purl.uniprot.org/uniprot/P9WHF1 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Sequence Conflict ^@ Nucleophile; for GTP cyclohydrolase activity|||Proton acceptor; for GTP cyclohydrolase activity|||Riboflavin biosynthesis protein RibBA ^@ http://purl.uniprot.org/annotation/PRO_0000151728 http://togogenome.org/gene/83332:Rv1377c ^@ http://purl.uniprot.org/uniprot/P71805 ^@ Region ^@ Domain Extent ^@ Methyltransf_25 ^@ http://togogenome.org/gene/83332:Rv2063 ^@ http://purl.uniprot.org/uniprot/P9WJ85 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Strand ^@ Antitoxin MazE7|||Basic and acidic residues ^@ http://purl.uniprot.org/annotation/PRO_0000406301 http://togogenome.org/gene/83332:Rv1908c ^@ http://purl.uniprot.org/uniprot/I6YBX7|||http://purl.uniprot.org/uniprot/P9WIE5 ^@ Experimental Information|||Modification|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink|||Domain Extent|||Helix|||Mutagenesis Site|||Sequence Conflict|||Sequence Variant|||Strand|||Turn ^@ 20-fold decrease in the rate of INH-NAD adduct formation. Exhibits significantly reduced affinity for INH (KM is increased by 43-fold).|||Catalase-peroxidase|||Exhibits 1.7-fold decreased catalytic efficiency for the activation of INH.|||Exhibits 2-fold increased affinity for INH.|||Exhibits 8-fold increased catalytic efficiency for the activation of INH (INH-NAD formation). Possesses an enlarged substrate access channel.|||In strain: 15726/89; INH-resistant.|||In strain: H0004/93; INH-resistant.|||In strain: H0169/93; INH-resistant.|||In strain: H0181/94, H0452/92, H0948/92 and H0169/93; INH-resistant.|||In strain: H0251/90; INH-resistant.|||In strain: H0892/92; INH-resistant.|||In strain: H0948/92; INH-resistant.|||Nearly no effect on the kinetic parameters for the activation of INH.|||Nearly no effect on the kinetic parameters for the catalase and peroxidase activity. Activates INH and mediates InhA inactivation as efficiently as wild-type.|||PEROXIDASE_4|||Proton acceptor|||Tryptophan radical intermediate|||Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255); alternate|||Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-107)|||Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107); alternate|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000055574 http://togogenome.org/gene/83332:Rv0375c ^@ http://purl.uniprot.org/uniprot/I6Y7N2 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv1554 ^@ http://purl.uniprot.org/uniprot/P9WNB7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Fumarate reductase subunit C|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000196531 http://togogenome.org/gene/83332:Rv1213 ^@ http://purl.uniprot.org/uniprot/P9WN43 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Glucose-1-phosphate adenylyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000195309 http://togogenome.org/gene/83332:Rv1722 ^@ http://purl.uniprot.org/uniprot/P71980 ^@ Region ^@ Domain Extent ^@ ATP-grasp ^@ http://togogenome.org/gene/83332:Rv2907c ^@ http://purl.uniprot.org/uniprot/P9WH19 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ PRC barrel|||Ribosome maturation factor RimM ^@ http://purl.uniprot.org/annotation/PRO_0000163320 http://togogenome.org/gene/83332:Rv1878 ^@ http://purl.uniprot.org/uniprot/O07752 ^@ Region ^@ Domain Extent ^@ GS catalytic ^@ http://togogenome.org/gene/83332:Rv0061c ^@ http://purl.uniprot.org/uniprot/I6X8E6 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Secreted protein ^@ http://purl.uniprot.org/annotation/PRO_5003706633 http://togogenome.org/gene/83332:Rv3581c ^@ http://purl.uniprot.org/uniprot/P9WKG5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000189485 http://togogenome.org/gene/83332:Rv2533c ^@ http://purl.uniprot.org/uniprot/P9WIV1 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ Transcription antitermination protein NusB ^@ http://purl.uniprot.org/annotation/PRO_0000176557 http://togogenome.org/gene/83332:Rv3725 ^@ http://purl.uniprot.org/uniprot/O69692 ^@ Region ^@ Domain Extent ^@ Epimerase ^@ http://togogenome.org/gene/83332:Rv3895c ^@ http://purl.uniprot.org/uniprot/P9WNR5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-2 secretion system ATPase EccB2|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393229 http://togogenome.org/gene/83332:Rv3360 ^@ http://purl.uniprot.org/uniprot/O50389 ^@ Region ^@ Domain Extent ^@ FHA ^@ http://togogenome.org/gene/83332:Rv0233 ^@ http://purl.uniprot.org/uniprot/P9WH69 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Turn ^@ 3-(O4'-tyrosyl)-valine (Val-Tyr)|||R2-like ligand binding oxidase ^@ http://purl.uniprot.org/annotation/PRO_0000375432 http://togogenome.org/gene/83332:Rv0601c ^@ http://purl.uniprot.org/uniprot/O07777 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||Extracellular|||HAMP|||Helical|||Histidine kinase; first part|||Phosphohistidine; by autocatalysis|||Sensor histidine kinase component HK2 ^@ http://purl.uniprot.org/annotation/PRO_0000391080 http://togogenome.org/gene/83332:Rv1994c ^@ http://purl.uniprot.org/uniprot/P9WMI9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mass|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes metal-induced derepression.|||HTH arsR-type|||HTH-type transcriptional regulator CmtR|||Loss of repressor activity.|||No effect.|||The measured mass is that of a dimer, plus 2 cadmium ions.|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000160629 http://togogenome.org/gene/83332:Rv3549c ^@ http://purl.uniprot.org/uniprot/I6YCE1 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv0064 ^@ http://purl.uniprot.org/uniprot/P9WFL5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||UPF0182 protein Rv0064 ^@ http://purl.uniprot.org/annotation/PRO_0000157723 http://togogenome.org/gene/83332:Rv0896 ^@ http://purl.uniprot.org/uniprot/P9WPD5 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Crosslink|||Helix|||Strand|||Turn ^@ Citrate synthase 1|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000169948 http://togogenome.org/gene/83332:Rv3843c ^@ http://purl.uniprot.org/uniprot/P96235 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DUF4328|||Helical ^@ http://togogenome.org/gene/83332:Rv0318c ^@ http://purl.uniprot.org/uniprot/Q6MX47 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0716 ^@ http://purl.uniprot.org/uniprot/P9WH83 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L5 ^@ http://purl.uniprot.org/annotation/PRO_0000124956 http://togogenome.org/gene/83332:Rv1567c ^@ http://purl.uniprot.org/uniprot/O06623 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2756c ^@ http://purl.uniprot.org/uniprot/O33298 ^@ Region ^@ Domain Extent ^@ HsdM_N|||N6_Mtase ^@ http://togogenome.org/gene/83332:Rv1397c ^@ http://purl.uniprot.org/uniprot/P9WFA7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC10 ^@ http://purl.uniprot.org/annotation/PRO_0000407872 http://togogenome.org/gene/83332:Rv0866 ^@ http://purl.uniprot.org/uniprot/P9WJR1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Molybdopterin synthase catalytic subunit 2 ^@ http://purl.uniprot.org/annotation/PRO_0000163088 http://togogenome.org/gene/83332:Rv2573 ^@ http://purl.uniprot.org/uniprot/P9WIL1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand ^@ 2-dehydropantoate 2-reductase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000157316 http://togogenome.org/gene/83332:Rv2992c ^@ http://purl.uniprot.org/uniprot/P9WFV9 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Motif|||Strand|||Turn ^@ 'HIGH' region|||'KMSKS' region|||Glutamate--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000119610 http://togogenome.org/gene/83332:Rv1364c ^@ http://purl.uniprot.org/uniprot/P9WLZ7 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes autophosphorylation.|||Decreases ATPase activity. Abolishes autophosphorylation. Can still be phosphorylated by PknD.|||Does not affect ATPase activity. Abolishes autophosphorylation.|||Does not affect autophosphorylation. 10-fold decrease in phosphatase activity.|||Leads to the accumulation of the autophosphorylated protein. 10-fold decrease in phosphatase activity.|||Multidomain regulatory protein Rv1364c|||PAC|||PPM-type phosphatase|||Phosphoserine; by PknD|||Phosphoserine; by autocatalysis|||Phosphothreonine; by PknD|||STAS|||Strong decrease in ATPase activity. Abolishes autophosphorylation. ^@ http://purl.uniprot.org/annotation/PRO_0000103833 http://togogenome.org/gene/83332:Rv3042c ^@ http://purl.uniprot.org/uniprot/O53289 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Mutagenesis Site ^@ ACT 1|||ACT 2|||Completely abolishes enzymatic activity (PubMed:25521849). Decreases enzymatic activity by 60% (PubMed:25037224).|||Completely abolishes enzymatic activity.|||Decreases enzymatic activity by 15%.|||Decreases enzymatic activity by 50%.|||Decreases enzymatic activity by 55%. Completely abolishes enzymatic activity, does not elicit cytoskeletal rearrangements, and does not suppress IL-8 production after TNF-alpha stimulation; when associated with N-341.|||Decreases enzymatic activity by 80%.|||Decreases enzymatic activity by 85%. Completely abolishes enzymatic activity, does not elicit cytoskeletal rearrangements, and does not suppress IL-8 production after TNF-alpha stimulation; when associated with N-345.|||Does not bind L-serine and correspondingly no oligomeric transitions is observed in the presence of L-serine.|||No effect on enzymatic activity.|||Nucleophile|||Phosphoserine phosphatase SerB2|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000437672 http://togogenome.org/gene/83332:Rv1682 ^@ http://purl.uniprot.org/uniprot/O33184 ^@ Region ^@ Coiled-Coil ^@ ^@ http://togogenome.org/gene/83332:Rv0298 ^@ http://purl.uniprot.org/uniprot/P9WJ09 ^@ Molecule Processing ^@ Chain ^@ Antitoxin Rv0298 ^@ http://purl.uniprot.org/annotation/PRO_0000406884 http://togogenome.org/gene/83332:Rv3227 ^@ http://purl.uniprot.org/uniprot/P9WPY5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ 3-phosphoshikimate 1-carboxyvinyltransferase|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000088273 http://togogenome.org/gene/83332:Rv2875 ^@ http://purl.uniprot.org/uniprot/P9WNF5 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Signal Peptide|||Strand|||Turn ^@ FAS1|||Immunogenic protein MPT70 ^@ http://purl.uniprot.org/annotation/PRO_0000008786 http://togogenome.org/gene/83332:Rv1514c ^@ http://purl.uniprot.org/uniprot/P9WMX9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized glycosyltransferase Rv1514c ^@ http://purl.uniprot.org/annotation/PRO_0000059249 http://togogenome.org/gene/83332:Rv2696c ^@ http://purl.uniprot.org/uniprot/I6XF31 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv3560c ^@ http://purl.uniprot.org/uniprot/I6Y3V5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Acyl-CoA dehydrogenase IpdE1|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000452315 http://togogenome.org/gene/83332:Rv3010c ^@ http://purl.uniprot.org/uniprot/P9WID7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ ATP-dependent 6-phosphofructokinase|||Proton acceptor|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000111968 http://togogenome.org/gene/83332:Rv2522c ^@ http://purl.uniprot.org/uniprot/I6X4J0 ^@ Region ^@ Domain Extent ^@ M20_dimer ^@ http://togogenome.org/gene/83332:Rv0417 ^@ http://purl.uniprot.org/uniprot/P9WG73 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Schiff-base intermediate with DXP|||Thiazole synthase ^@ http://purl.uniprot.org/annotation/PRO_0000162832 http://togogenome.org/gene/83332:Rv2455c ^@ http://purl.uniprot.org/uniprot/O53182 ^@ Molecule Processing ^@ Chain ^@ 2-oxoglutarate oxidoreductase subunit KorA ^@ http://purl.uniprot.org/annotation/PRO_0000420516 http://togogenome.org/gene/83332:Rv0238 ^@ http://purl.uniprot.org/uniprot/O53661 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1425 ^@ http://purl.uniprot.org/uniprot/P9WKC1 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv1425 ^@ http://purl.uniprot.org/annotation/PRO_0000222908 http://togogenome.org/gene/83332:Rv0561c ^@ http://purl.uniprot.org/uniprot/P9WNY9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Menaquinone reductase ^@ http://purl.uniprot.org/annotation/PRO_0000419774 http://togogenome.org/gene/83332:Rv0204c ^@ http://purl.uniprot.org/uniprot/I6Y748 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1920 ^@ http://purl.uniprot.org/uniprot/O53962 ^@ Region ^@ Domain Extent ^@ PlsC ^@ http://togogenome.org/gene/83332:Rv3686c ^@ http://purl.uniprot.org/uniprot/O69654 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0389 ^@ http://purl.uniprot.org/uniprot/P95197 ^@ Region ^@ Domain Extent ^@ ATP-grasp ^@ http://togogenome.org/gene/83332:Rv0910 ^@ http://purl.uniprot.org/uniprot/P9WJ05 ^@ Molecule Processing ^@ Chain ^@ Toxin Rv0910 ^@ http://purl.uniprot.org/annotation/PRO_0000406885 http://togogenome.org/gene/83332:Rv2091c ^@ http://purl.uniprot.org/uniprot/P9WLJ5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues|||Uncharacterized protein Rv2091c ^@ http://purl.uniprot.org/annotation/PRO_0000103961 http://togogenome.org/gene/83332:Rv0877 ^@ http://purl.uniprot.org/uniprot/P9WKR3 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Removed|||Uncharacterized protein Rv0877 ^@ http://purl.uniprot.org/annotation/PRO_0000103721 http://togogenome.org/gene/83332:Rv1224 ^@ http://purl.uniprot.org/uniprot/P9WG99 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Sec-independent protein translocase protein TatB ^@ http://purl.uniprot.org/annotation/PRO_0000192661 http://togogenome.org/gene/83332:Rv1732c ^@ http://purl.uniprot.org/uniprot/P71990 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Thioredoxin ^@ http://purl.uniprot.org/annotation/PRO_5010332137 http://togogenome.org/gene/83332:Rv2056c ^@ http://purl.uniprot.org/uniprot/P9WH59 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 30S ribosomal protein S14|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000130912 http://togogenome.org/gene/83332:Rv1890c ^@ http://purl.uniprot.org/uniprot/O07742 ^@ Region ^@ Domain Extent ^@ YceI ^@ http://togogenome.org/gene/83332:Rv0124 ^@ http://purl.uniprot.org/uniprot/Q79G08 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5004286890 http://togogenome.org/gene/83332:Rv2404c ^@ http://purl.uniprot.org/uniprot/P9WK97 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Elongation factor 4|||tr-type G ^@ http://purl.uniprot.org/annotation/PRO_0000176307 http://togogenome.org/gene/83332:Rv3592 ^@ http://purl.uniprot.org/uniprot/P9WKH3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ ABM|||Heme oxygenase (mycobilin-producing)|||Inactive.|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000422665 http://togogenome.org/gene/83332:Rv0504c ^@ http://purl.uniprot.org/uniprot/P9WFK3 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ MaoC-like|||N-acetylthreonine|||Removed|||UPF0336 protein Rv0504c ^@ http://purl.uniprot.org/annotation/PRO_0000216142 http://togogenome.org/gene/83332:Rv2716 ^@ http://purl.uniprot.org/uniprot/P9WL43 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2716 ^@ http://purl.uniprot.org/annotation/PRO_0000104083 http://togogenome.org/gene/83332:Rv2543 ^@ http://purl.uniprot.org/uniprot/P9WK81 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Lipid Binding|||Signal Peptide|||Strand|||Turn ^@ N-palmitoyl cysteine|||Putative lipoprotein LppA|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000361670 http://togogenome.org/gene/83332:Rv2548A ^@ http://purl.uniprot.org/uniprot/I6XEK2 ^@ Region ^@ Coiled-Coil ^@ ^@ http://togogenome.org/gene/83332:Rv3905c ^@ http://purl.uniprot.org/uniprot/P9WNH7 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxF ^@ http://purl.uniprot.org/annotation/PRO_0000167820 http://togogenome.org/gene/83332:Rv2004c ^@ http://purl.uniprot.org/uniprot/P9WLN3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized protein Rv2004c ^@ http://purl.uniprot.org/annotation/PRO_0000103932 http://togogenome.org/gene/83332:Rv1067c ^@ http://purl.uniprot.org/uniprot/Q79FT3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5004287635 http://togogenome.org/gene/83332:Rv0079 ^@ http://purl.uniprot.org/uniprot/P9WMA9 ^@ Molecule Processing ^@ Chain ^@ Dormancy associated translation inhibitor ^@ http://purl.uniprot.org/annotation/PRO_0000392679 http://togogenome.org/gene/83332:Rv1436 ^@ http://purl.uniprot.org/uniprot/P9WN83 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Mutagenesis Site ^@ Glyceraldehyde-3-phosphate dehydrogenase|||Loss of dehydrogenase activity.|||Nucleophile|||Same dehydrogenase activity compared to the wild-type. ^@ http://purl.uniprot.org/annotation/PRO_0000145671 http://togogenome.org/gene/83332:Rv0906 ^@ http://purl.uniprot.org/uniprot/P9WKP3 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized protein Rv0906 ^@ http://purl.uniprot.org/annotation/PRO_0000014085 http://togogenome.org/gene/83332:Rv3853 ^@ http://purl.uniprot.org/uniprot/P9WGY3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand ^@ Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase ^@ http://purl.uniprot.org/annotation/PRO_0000209623 http://togogenome.org/gene/83332:Rv1097c ^@ http://purl.uniprot.org/uniprot/O53445 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0727c ^@ http://purl.uniprot.org/uniprot/P95075 ^@ Region ^@ Domain Extent ^@ Aldolase_II ^@ http://togogenome.org/gene/83332:Rv3330 ^@ http://purl.uniprot.org/uniprot/O53380 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Signal Peptide|||Strand|||Transmembrane|||Turn ^@ 60% decrease in phosphorylation by PknH.|||Acyl-ester intermediate|||D-alanyl-D-alanine carboxypeptidase DacB1|||Helical|||Phosphothreonine; by PknH|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_5010219484 http://togogenome.org/gene/83332:Rv1407 ^@ http://purl.uniprot.org/uniprot/P9WGX3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Nucleophile|||Putative methyltransferase Rv1407 ^@ http://purl.uniprot.org/annotation/PRO_0000211823 http://togogenome.org/gene/83332:Rv2234 ^@ http://purl.uniprot.org/uniprot/P9WIA1 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 11-fold decrease in catalytic efficiency toward pNPP at pH 7.0.|||Does not affect nitrosylation. 80% decrease in phosphatase activity.|||Lack of nitrosylation. Does not affect phosphatase activity.|||Loss of phosphatase activity.|||Loss of phosphatase activity. Inhibits its dephosphorylation activity on human VPS33B. 36-fold decrease in catalytic efficiency toward pNPP at pH 7.0.|||Loss of phosphatase activity. Inhibits its dephosphorylation activity on human VPS33B. Reduces its effect on phagolysosome fusion in infected macrophages. Does not affect nitrosylation.|||Loss of phosphatase activity. Inhibits its dephosphorylation activity on human VPS33B. Reduces its effect on phagolysosome fusion in infected macrophages. Still binds V-ATPase subunit H. 380-fold decrease in catalytic efficiency toward pNPP at pH 7.0.|||Loss of phosphatase activity; when associated with E-128.|||Loss of phosphatase activity; when associated with E-129.|||Low molecular weight protein-tyrosine phosphatase A|||Mutant can be phosphorylated.|||Mutant can be phosphorylated. Lack of phosphorylation and loss of phosphatase activity; when associated with A-128.|||Mutant can be phosphorylated. Lack of phosphorylation and loss of phosphatase activity; when associated with A-129.|||No change in phosphatase activity.|||No longer binds to ubiquitin. Abolishes the Jnk- and p38-dependent production of TNF and IL-1-beta in macrophages. Also abolishes the PtpA-mediated inhibition of phagosome acidification.|||Nucleophile|||Phosphothreonine; by PknA|||Phosphotyrosine|||Proton donor|||Retains phosphatase activity but does not bind V-ATPase subunit H. Fails to inhibit V-ATPase trafficking to phagosomes and shows impaired intracellular survival.|||S-nitrosocysteine|||Slight decrease in phosphatase activity.|||Strong decrease in phosphatase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000046567 http://togogenome.org/gene/83332:Rv1441c ^@ http://purl.uniprot.org/uniprot/Q79FP3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS26 ^@ http://purl.uniprot.org/annotation/PRO_5004286886 http://togogenome.org/gene/83332:Rv3053c ^@ http://purl.uniprot.org/uniprot/I6YB06 ^@ Modification|||Region ^@ Disulfide Bond|||Domain Extent ^@ Glutaredoxin ^@ http://togogenome.org/gene/83332:Rv0310c ^@ http://purl.uniprot.org/uniprot/O07237 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv1692 ^@ http://purl.uniprot.org/uniprot/O33194 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ D-glycerol 3-phosphate phosphatase|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000435901 http://togogenome.org/gene/83332:Rv2061c ^@ http://purl.uniprot.org/uniprot/O86340 ^@ Region ^@ Domain Extent ^@ Putative_PNPOx ^@ http://togogenome.org/gene/83332:Rv3241c ^@ http://purl.uniprot.org/uniprot/O05886 ^@ Molecule Processing ^@ Chain ^@ Ribosome hibernation promotion factor ^@ http://purl.uniprot.org/annotation/PRO_0000436446 http://togogenome.org/gene/83332:Rv2888c ^@ http://purl.uniprot.org/uniprot/P9WQ95 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acyl-ester intermediate|||Charge relay system|||Putative amidase AmiC ^@ http://purl.uniprot.org/annotation/PRO_0000105258 http://togogenome.org/gene/83332:Rv1524 ^@ http://purl.uniprot.org/uniprot/P9WN07 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized glycosyltransferase Rv1524 ^@ http://purl.uniprot.org/annotation/PRO_0000215623 http://togogenome.org/gene/83332:Rv3057c ^@ http://purl.uniprot.org/uniprot/I6YB11 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv3024c ^@ http://purl.uniprot.org/uniprot/P9WJS5 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond ^@ Cysteine persulfide intermediate|||Nucleophile|||tRNA-specific 2-thiouridylase MnmA ^@ http://purl.uniprot.org/annotation/PRO_0000121656 http://togogenome.org/gene/83332:Rv3571 ^@ http://purl.uniprot.org/uniprot/P9WJ93 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ 2Fe-2S ferredoxin-type|||3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component|||FAD-binding FR-type ^@ http://purl.uniprot.org/annotation/PRO_0000404100 http://togogenome.org/gene/83332:Rv0427c ^@ http://purl.uniprot.org/uniprot/P96273 ^@ Region ^@ Domain Extent ^@ Endo/exonuclease/phosphatase ^@ http://togogenome.org/gene/83332:Rv3365c ^@ http://purl.uniprot.org/uniprot/Q93IG6 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ HAMP|||HATPase_c|||Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv2468c ^@ http://purl.uniprot.org/uniprot/P9WLA7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2468c ^@ http://purl.uniprot.org/annotation/PRO_0000396081 http://togogenome.org/gene/83332:Rv0248c ^@ http://purl.uniprot.org/uniprot/O53670 ^@ Region ^@ Domain Extent ^@ FAD_binding_2|||Succ_DH_flav_C ^@ http://togogenome.org/gene/83332:Rv1109c ^@ http://purl.uniprot.org/uniprot/P9WM59 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Initiator Methionine ^@ Polar residues|||Removed|||Uncharacterized protein Rv1109c ^@ http://purl.uniprot.org/annotation/PRO_0000403669 http://togogenome.org/gene/83332:Rv0571c ^@ http://purl.uniprot.org/uniprot/P9WHK1 ^@ Molecule Processing ^@ Chain ^@ Putative phosphoribosyl transferase Rv0571c ^@ http://purl.uniprot.org/annotation/PRO_0000392688 http://togogenome.org/gene/83332:Rv3696c ^@ http://purl.uniprot.org/uniprot/P9WPK1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Glycerol kinase ^@ http://purl.uniprot.org/annotation/PRO_0000059472 http://togogenome.org/gene/83332:Rv0442c ^@ http://purl.uniprot.org/uniprot/P9WI41 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Sequence Conflict ^@ PPE family protein PPE10|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000217843 http://togogenome.org/gene/83332:Rv0399c ^@ http://purl.uniprot.org/uniprot/P95207 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ Beta-lactamase ^@ http://purl.uniprot.org/annotation/PRO_5030174932 http://togogenome.org/gene/83332:Rv0922 ^@ http://purl.uniprot.org/uniprot/I6Y560 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ OrfB_IS605|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2103c ^@ http://purl.uniprot.org/uniprot/O53501 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC37 ^@ http://purl.uniprot.org/annotation/PRO_0000407892 http://togogenome.org/gene/83332:Rv2584c ^@ http://purl.uniprot.org/uniprot/P9WQ07 ^@ Molecule Processing ^@ Chain ^@ Adenine phosphoribosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000149420 http://togogenome.org/gene/83332:Rv1229c ^@ http://purl.uniprot.org/uniprot/P9WJN7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Iron-sulfur cluster carrier protein ^@ http://purl.uniprot.org/annotation/PRO_0000184938 http://togogenome.org/gene/83332:Rv0169 ^@ http://purl.uniprot.org/uniprot/Q79FZ9 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv2761c ^@ http://purl.uniprot.org/uniprot/I6YEB1 ^@ Region ^@ Domain Extent ^@ Methylase_S ^@ http://togogenome.org/gene/83332:Rv2415c ^@ http://purl.uniprot.org/uniprot/P71728 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Basic and acidic residues|||Helical|||HhH1|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3251c ^@ http://purl.uniprot.org/uniprot/O05894 ^@ Region ^@ Domain Extent ^@ Rubredoxin-like ^@ http://togogenome.org/gene/83332:Rv3605c ^@ http://purl.uniprot.org/uniprot/O06277 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0516c ^@ http://purl.uniprot.org/uniprot/O33361 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ Lack of phosphorylation by PknD. Reduced oprA induction in response to osmotic stress.|||Osmosensory protein A|||Phosphothreonine; by PknD|||STAS ^@ http://purl.uniprot.org/annotation/PRO_0000451030 http://togogenome.org/gene/83332:Rv2726c ^@ http://purl.uniprot.org/uniprot/P9WP19 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Completely abolishes the diaminopimelate epimerase activity.|||Diaminopimelate epimerase|||Proton acceptor|||Proton donor|||Strongly reduces the diaminopimelate epimerase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000149853 http://togogenome.org/gene/83332:Rv2223c ^@ http://purl.uniprot.org/uniprot/P9WHR5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Signal Peptide ^@ AB hydrolase-1|||Carboxylesterase B|||Nucleophile|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000027327 http://togogenome.org/gene/83332:Rv3068c ^@ http://purl.uniprot.org/uniprot/I6Y2G3 ^@ Region ^@ Domain Extent ^@ PGM_PMM_I|||PGM_PMM_II|||PGM_PMM_III|||PGM_PMM_IV ^@ http://togogenome.org/gene/83332:Rv2667 ^@ http://purl.uniprot.org/uniprot/P9WPC7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Clp R|||Uncharacterized protein Rv2667 ^@ http://purl.uniprot.org/annotation/PRO_0000191238 http://togogenome.org/gene/83332:Rv2553c ^@ http://purl.uniprot.org/uniprot/I6XEK6 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv1199c ^@ http://purl.uniprot.org/uniprot/P60230 ^@ Molecule Processing ^@ Chain ^@ Transposase for insertion sequence element IS1081 ^@ http://purl.uniprot.org/annotation/PRO_0000211350 http://togogenome.org/gene/83332:Rv2050 ^@ http://purl.uniprot.org/uniprot/P9WHJ5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ RNA polymerase-binding protein RbpA ^@ http://purl.uniprot.org/annotation/PRO_0000423656 http://togogenome.org/gene/83332:Rv2017 ^@ http://purl.uniprot.org/uniprot/O53463 ^@ Region ^@ Domain Extent ^@ HTH cro/C1-type ^@ http://togogenome.org/gene/83332:Rv1135c ^@ http://purl.uniprot.org/uniprot/P9WI29 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Uncharacterized PPE family protein PPE16 ^@ http://purl.uniprot.org/annotation/PRO_0000379587 http://togogenome.org/gene/83332:Rv2691 ^@ http://purl.uniprot.org/uniprot/I6XF25 ^@ Region ^@ Domain Extent ^@ RCK C-terminal|||RCK N-terminal ^@ http://togogenome.org/gene/83332:Rv0089 ^@ http://purl.uniprot.org/uniprot/P9WK03 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized methyltransferase Rv0089 ^@ http://purl.uniprot.org/annotation/PRO_0000204441 http://togogenome.org/gene/83332:Rv1447c ^@ http://purl.uniprot.org/uniprot/P9WN73 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Glucose-6-phosphate 1-dehydrogenase 2|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000068126 http://togogenome.org/gene/83332:Rv2673 ^@ http://purl.uniprot.org/uniprot/P9WMZ7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Alpha-(1->3)-arabinofuranosyltransferase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000420579 http://togogenome.org/gene/83332:Rv0738 ^@ http://purl.uniprot.org/uniprot/P9WKS3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0738 ^@ http://purl.uniprot.org/annotation/PRO_0000403672 http://togogenome.org/gene/83332:Rv0409 ^@ http://purl.uniprot.org/uniprot/P9WQH1 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Acetate kinase|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000107589 http://togogenome.org/gene/83332:Rv1589 ^@ http://purl.uniprot.org/uniprot/P9WPQ7 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ Biotin synthase|||N-acetylthreonine|||Radical SAM core|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000185560 http://togogenome.org/gene/83332:Rv3342 ^@ http://purl.uniprot.org/uniprot/P9WK01 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized methyltransferase Rv3342 ^@ http://purl.uniprot.org/annotation/PRO_0000204443 http://togogenome.org/gene/83332:Rv1417 ^@ http://purl.uniprot.org/uniprot/P9WLY1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1417 ^@ http://purl.uniprot.org/annotation/PRO_0000103843 http://togogenome.org/gene/83332:Rv2244 ^@ http://purl.uniprot.org/uniprot/P9WQF3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Abolishes activation by PptT.|||Carrier|||Meromycolate extension acyl carrier protein|||O-(pantetheine 4'-phosphoryl)serine ^@ http://purl.uniprot.org/annotation/PRO_0000180247 http://togogenome.org/gene/83332:Rv0037c ^@ http://purl.uniprot.org/uniprot/P9WJY1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized MFS-type transporter Rv0037c ^@ http://purl.uniprot.org/annotation/PRO_0000103654 http://togogenome.org/gene/83332:Rv3618 ^@ http://purl.uniprot.org/uniprot/I6X7W8 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv0321 ^@ http://purl.uniprot.org/uniprot/P9WP17 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton donor/acceptor|||dCTP deaminase, dUMP-forming ^@ http://purl.uniprot.org/annotation/PRO_0000155997 http://togogenome.org/gene/83332:Rv1702c ^@ http://purl.uniprot.org/uniprot/P9WLT3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1702cMb1728c ^@ http://purl.uniprot.org/annotation/PRO_0000103894 http://togogenome.org/gene/83332:Rv2072c ^@ http://purl.uniprot.org/uniprot/P9WGA9 ^@ Molecule Processing ^@ Chain ^@ Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] ^@ http://purl.uniprot.org/annotation/PRO_0000150409 http://togogenome.org/gene/83332:Rv3759c ^@ http://purl.uniprot.org/uniprot/O69725 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ OpuAC ^@ http://purl.uniprot.org/annotation/PRO_5010212199 http://togogenome.org/gene/83332:Rv1534 ^@ http://purl.uniprot.org/uniprot/O08377 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv3583c ^@ http://purl.uniprot.org/uniprot/P9WJG3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ RNA polymerase-binding transcription factor CarD|||Weakens interaction with RpoB, decreases growth rate and virulence, and increases rifampicin sensitivity. Abolishes interaction with RpoB; when associated with E-25.|||Weakens interaction with RpoB. Abolishes interaction with RpoB; when associated with E-47. ^@ http://purl.uniprot.org/annotation/PRO_0000420262 http://togogenome.org/gene/83332:Rv2373c ^@ http://purl.uniprot.org/uniprot/P9WNV7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Repeat|||Zinc Finger ^@ CR-type|||CXXCXGXG motif|||Chaperone protein DnaJ 2|||J ^@ http://purl.uniprot.org/annotation/PRO_0000070836 http://togogenome.org/gene/83332:Rv0437c ^@ http://purl.uniprot.org/uniprot/P9WHQ5 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Modified Residue ^@ Phosphatidylserine decarboxylase alpha chain|||Phosphatidylserine decarboxylase beta chain|||Pyruvic acid (Ser); by autocatalysis|||Schiff-base intermediate with substrate; via pyruvic acid ^@ http://purl.uniprot.org/annotation/PRO_0000029779|||http://purl.uniprot.org/annotation/PRO_0000029780 http://togogenome.org/gene/83332:Rv2195 ^@ http://purl.uniprot.org/uniprot/P9WH23 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Strand|||Transmembrane|||Turn ^@ Cytochrome bc1 complex Rieske iron-sulfur subunit|||Helical|||Rieske ^@ http://purl.uniprot.org/annotation/PRO_0000127792 http://togogenome.org/gene/83332:Rv3029c ^@ http://purl.uniprot.org/uniprot/P9WNG7 ^@ Molecule Processing ^@ Chain ^@ Electron transfer flavoprotein subunit beta ^@ http://purl.uniprot.org/annotation/PRO_0000167882 http://togogenome.org/gene/83332:Rv3377c ^@ http://purl.uniprot.org/uniprot/O50406 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Loss of cyclase activity.|||No change.|||Type B diterpene cyclase ^@ http://purl.uniprot.org/annotation/PRO_0000416457 http://togogenome.org/gene/83332:Rv0620 ^@ http://purl.uniprot.org/uniprot/P9WN63 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Galactokinase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000184619 http://togogenome.org/gene/83332:Rv3876 ^@ http://purl.uniprot.org/uniprot/P9WJC5 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Mutagenesis Site ^@ Basic and acidic residues|||Basic residues|||Does not block ESX-1-mediated secretion during ATP depletion. Lack of ATP-binding.|||ESX-1 secretion-associated protein EspI|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000394147 http://togogenome.org/gene/83332:Rv0261c ^@ http://purl.uniprot.org/uniprot/P95218 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1120c ^@ http://purl.uniprot.org/uniprot/O06572 ^@ Region ^@ Domain Extent ^@ Guanylate cyclase ^@ http://togogenome.org/gene/83332:Rv0582 ^@ http://purl.uniprot.org/uniprot/O53779 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ PINc|||Ribonuclease VapC26 ^@ http://purl.uniprot.org/annotation/PRO_0000407885 http://togogenome.org/gene/83332:Rv3706c ^@ http://purl.uniprot.org/uniprot/I6X849 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0937c ^@ http://purl.uniprot.org/uniprot/P9WKD9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Ku|||Non-homologous end joining protein Ku ^@ http://purl.uniprot.org/annotation/PRO_0000425945 http://togogenome.org/gene/83332:Rv3880c ^@ http://purl.uniprot.org/uniprot/P9WJB9 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ ESX-1 secretion-associated protein EspL|||N-acetylserine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000394150 http://togogenome.org/gene/83332:Rv1762c ^@ http://purl.uniprot.org/uniprot/O06797 ^@ Molecule Processing ^@ Chain ^@ Encapsulin nanocompartment protein Rv1762c ^@ http://purl.uniprot.org/annotation/PRO_0000455334 http://togogenome.org/gene/83332:Rv2595 ^@ http://purl.uniprot.org/uniprot/P9WFC3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Antitoxin VapB40|||SpoVT-AbrB ^@ http://purl.uniprot.org/annotation/PRO_0000104063 http://togogenome.org/gene/83332:Rv1239c ^@ http://purl.uniprot.org/uniprot/O50455 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1593c ^@ http://purl.uniprot.org/uniprot/O06597 ^@ Region ^@ Domain Extent ^@ Nudix hydrolase ^@ http://togogenome.org/gene/83332:Rv2775 ^@ http://purl.uniprot.org/uniprot/O33317 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv1556 ^@ http://purl.uniprot.org/uniprot/P9WMD1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ HTH tetR-type|||Uncharacterized HTH-type transcriptional regulator Rv1556 ^@ http://purl.uniprot.org/annotation/PRO_0000070664 http://togogenome.org/gene/83332:Rv3261 ^@ http://purl.uniprot.org/uniprot/P9WP81 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Phosphoenolpyruvate transferase ^@ http://purl.uniprot.org/annotation/PRO_0000145763 http://togogenome.org/gene/83332:Rv0530 ^@ http://purl.uniprot.org/uniprot/O06396 ^@ Region ^@ Domain Extent ^@ CbiA ^@ http://togogenome.org/gene/83332:Rv2736c ^@ http://purl.uniprot.org/uniprot/P9WHI1 ^@ Molecule Processing ^@ Chain ^@ Regulatory protein RecX ^@ http://purl.uniprot.org/annotation/PRO_0000162450 http://togogenome.org/gene/83332:Rv3112 ^@ http://purl.uniprot.org/uniprot/L7N6B4 ^@ Molecule Processing ^@ Chain ^@ Molybdopterin synthase sulfur carrier subunit ^@ http://purl.uniprot.org/annotation/PRO_0000438347 http://togogenome.org/gene/83332:Rv3079c ^@ http://purl.uniprot.org/uniprot/I6XG43 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv2769c ^@ http://purl.uniprot.org/uniprot/Q79FA8 ^@ Region ^@ Domain Extent ^@ PE|||PPE-SVP ^@ http://togogenome.org/gene/83332:Rv2565 ^@ http://purl.uniprot.org/uniprot/P9WIY7 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Motif ^@ DGA/G|||GXGXXG|||GXSXG|||Nucleophile|||PNPLA|||Proton acceptor|||Uncharacterized NTE family protein Rv2565 ^@ http://purl.uniprot.org/annotation/PRO_0000172536 http://togogenome.org/gene/83332:Rv1214c ^@ http://purl.uniprot.org/uniprot/L7N6A7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ PE ^@ http://purl.uniprot.org/annotation/PRO_5010314126 http://togogenome.org/gene/83332:Rv3391 ^@ http://purl.uniprot.org/uniprot/O50417 ^@ Region ^@ Domain Extent ^@ Thioester reductase (TE) ^@ http://togogenome.org/gene/83332:Rv3763 ^@ http://purl.uniprot.org/uniprot/P9WK61 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Disulfide Bond|||Helix|||Lipid Binding|||Mass|||Mutagenesis Site|||Signal Peptide|||Strand ^@ Decreased ConA binding; altered protein processing yields 21 and 16 kDa forms in M.smegmatis.|||Decreased ConA binding; altered protein processing yields 21 and 17 kDa forms in M.smegmatis.|||Expressed in M.bovis, lipidated.|||Lipoprotein LpqH|||N-palmitoyl cysteine|||No ConA binding; altered protein processing yields 16 kDa soluble form starting on residue 40 in M.smegmatis. Protein poorly released into host cytoplasm (uses recombinant M.vaccae to infect mouse macrophages).|||Polar residues|||Protein not exported from cytoplasm, not released into host cytoplasm (uses recombinant M.vaccae to infect mouse macrophages).|||Protein not released into host cytoplasm (uses recombinant M.vaccae to infect mouse macrophages).|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018128 http://togogenome.org/gene/83332:Rv0100 ^@ http://purl.uniprot.org/uniprot/P9WM65 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue ^@ Acyl carrier protein Rv0100|||Carrier|||O-(pantetheine 4'-phosphoryl)serine ^@ http://purl.uniprot.org/annotation/PRO_0000103671 http://togogenome.org/gene/83332:Rv0630c ^@ http://purl.uniprot.org/uniprot/P9WMQ3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ For nuclease activity|||RecBCD enzyme subunit RecB|||UvrD-like helicase ATP-binding|||UvrD-like helicase C-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000102048 http://togogenome.org/gene/83332:Rv1459c ^@ http://purl.uniprot.org/uniprot/O53150 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Alpha-(1->6)-mannopyranosyltransferase Rv1459c|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000420594 http://togogenome.org/gene/83332:Rv3207c ^@ http://purl.uniprot.org/uniprot/O05859 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||ZnMc ^@ http://togogenome.org/gene/83332:Rv2686c ^@ http://purl.uniprot.org/uniprot/P9WJB3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Fluoroquinolones export permease protein Rv2686c|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000390879 http://togogenome.org/gene/83332:Rv0419 ^@ http://purl.uniprot.org/uniprot/P96265 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical ^@ http://purl.uniprot.org/annotation/PRO_5004162047 http://togogenome.org/gene/83332:Rv3357 ^@ http://purl.uniprot.org/uniprot/P9WF25 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand ^@ Antitoxin RelJ ^@ http://purl.uniprot.org/annotation/PRO_0000213742 http://togogenome.org/gene/83332:Rv0220 ^@ http://purl.uniprot.org/uniprot/P96402 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Esterase LipC ^@ http://purl.uniprot.org/annotation/PRO_0000448850 http://togogenome.org/gene/83332:Rv2785c ^@ http://purl.uniprot.org/uniprot/P9WH55 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S15 ^@ http://purl.uniprot.org/annotation/PRO_0000115473 http://togogenome.org/gene/83332:Rv0047c ^@ http://purl.uniprot.org/uniprot/P71704 ^@ Region ^@ Coiled-Coil|||Domain Extent ^@ PadR ^@ http://togogenome.org/gene/83332:Rv2254c ^@ http://purl.uniprot.org/uniprot/O53528 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1747 ^@ http://purl.uniprot.org/uniprot/O65934 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Modified Residue|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ ABC transmembrane type-2|||ABC transporter|||ABC transporter ATP-binding/permease protein Rv1747|||FHA 1|||FHA 2|||Helical|||Lack of phosphorylation. Attenuates growth in macrophages and in mice; when associated with A-152.|||Lack of phosphorylation. Attenuates growth in macrophages and in mice; when associated with A-210.|||Loss of ATPase activity.|||Phosphothreonine|||Polar residues|||Pro residues|||Strong decrease in phosphorylation.|||Strong decrease in phosphorylation. Decreases interaction with PknF.|||Strong decrease in phosphorylation. Lack of interaction with PknF. Attenuates growth in macrophages. ^@ http://purl.uniprot.org/annotation/PRO_0000419321 http://togogenome.org/gene/83332:Rv0893c ^@ http://purl.uniprot.org/uniprot/P9WFI1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0893c ^@ http://purl.uniprot.org/annotation/PRO_0000103733 http://togogenome.org/gene/83332:Rv0542c ^@ http://purl.uniprot.org/uniprot/P9WQ39 ^@ Molecule Processing ^@ Chain ^@ Probable 2-succinylbenzoate--CoA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000399477 http://togogenome.org/gene/83332:Rv1714 ^@ http://purl.uniprot.org/uniprot/P9WGQ3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv1714 ^@ http://purl.uniprot.org/annotation/PRO_0000415508 http://togogenome.org/gene/83332:Rv2082 ^@ http://purl.uniprot.org/uniprot/Q10690 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Polar residues|||Pro residues|||Uncharacterized protein Rv2082 ^@ http://purl.uniprot.org/annotation/PRO_0000103953 http://togogenome.org/gene/83332:Rv0713 ^@ http://purl.uniprot.org/uniprot/I6WZ58 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0256c ^@ http://purl.uniprot.org/uniprot/P9WI47 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Motif|||Mutagenesis Site ^@ Does not affect interaction with NCF2 and ROS production.|||Does not interact with NCF2 and cannot inhibit ROS production.|||Nuclear localization signal|||PPE family protein PPE2|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000378473 http://togogenome.org/gene/83332:Rv1544 ^@ http://purl.uniprot.org/uniprot/Q10782 ^@ Site ^@ Active Site ^@ Proton acceptor ^@ http://togogenome.org/gene/83332:Rv2383c ^@ http://purl.uniprot.org/uniprot/P9WQ63 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue ^@ Carrier 1|||Carrier 2|||O-(pantetheine 4'-phosphoryl)serine|||Phenyloxazoline synthase MbtB ^@ http://purl.uniprot.org/annotation/PRO_0000261306 http://togogenome.org/gene/83332:Rv2943A ^@ http://purl.uniprot.org/uniprot/Q6MX22 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic residues|||IstB_IS21 ^@ http://togogenome.org/gene/83332:Rv0449c ^@ http://purl.uniprot.org/uniprot/O53734 ^@ Region ^@ Domain Extent ^@ Amino_oxidase ^@ http://togogenome.org/gene/83332:Rv2730 ^@ http://purl.uniprot.org/uniprot/I6Y1K4 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv2205c ^@ http://purl.uniprot.org/uniprot/P9WMT7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2205c ^@ http://purl.uniprot.org/annotation/PRO_0000071539 http://togogenome.org/gene/83332:Rv3039c ^@ http://purl.uniprot.org/uniprot/P9WNN3 ^@ Molecule Processing ^@ Chain ^@ Probable enoyl-CoA hydratase EchA17 ^@ http://purl.uniprot.org/annotation/PRO_0000383565 http://togogenome.org/gene/83332:Rv3922c ^@ http://purl.uniprot.org/uniprot/P9WFL9 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Putative membrane protein insertion efficiency factor ^@ http://purl.uniprot.org/annotation/PRO_0000171841 http://togogenome.org/gene/83332:Rv2698 ^@ http://purl.uniprot.org/uniprot/I6X552 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3886c ^@ http://purl.uniprot.org/uniprot/O05458 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide|||Transmembrane ^@ Charge relay system|||Helical|||Mycosin-2|||Peptidase S8|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_5004157025 http://togogenome.org/gene/83332:Rv1131 ^@ http://purl.uniprot.org/uniprot/I6Y9Q3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ 2-methylcitrate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000432969 http://togogenome.org/gene/83332:Rv2872 ^@ http://purl.uniprot.org/uniprot/P9WF55 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC43 ^@ http://purl.uniprot.org/annotation/PRO_0000104087 http://togogenome.org/gene/83332:Rv3716c ^@ http://purl.uniprot.org/uniprot/P9WNR9 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Strand|||Turn ^@ Nucleoid-associated protein Rv3716c|||Pro residues ^@ http://purl.uniprot.org/annotation/PRO_0000170412 http://togogenome.org/gene/83332:Rv0948c ^@ http://purl.uniprot.org/uniprot/P9WIC1 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mass|||Mutagenesis Site ^@ Chorismate mutase|||Intracellular chorismate mutase|||It is catalytically catastrophic, but strongly activated by AroG.|||The catalytic efficiency and the affinity are 5 and 3-fold lower than the wild-type. The activation by AroG is 10-fold lower than the wild-type.|||The catalytic efficiency and the affinity are higher than the wild-type. The activation by AroG is 20-fold lower than the wild-type.|||The catalytic efficiency and the affinity are identical to the wild-type. The activation by AroG is 10-fold lower than the wild type.|||The catalytic efficiency and the affinity are slightly modified. The activation by AroG is 2-fold lower than the wild-type. ^@ http://purl.uniprot.org/annotation/PRO_0000119200 http://togogenome.org/gene/83332:Rv3811 ^@ http://purl.uniprot.org/uniprot/Q79F96 ^@ Region ^@ Domain Extent ^@ PGRP ^@ http://togogenome.org/gene/83332:Rv1775 ^@ http://purl.uniprot.org/uniprot/O33178 ^@ Region ^@ Domain Extent ^@ DAPG_hydrolase ^@ http://togogenome.org/gene/83332:Rv1427c ^@ http://purl.uniprot.org/uniprot/O06831 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv1250 ^@ http://purl.uniprot.org/uniprot/P9WG87 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized MFS-type transporter Rv1250 ^@ http://purl.uniprot.org/annotation/PRO_0000390688 http://togogenome.org/gene/83332:Rv1604 ^@ http://purl.uniprot.org/uniprot/O53907 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable inositol 1-monophosphatase ImpA ^@ http://purl.uniprot.org/annotation/PRO_0000404321 http://togogenome.org/gene/83332:Rv2437 ^@ http://purl.uniprot.org/uniprot/P71912 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3273 ^@ http://purl.uniprot.org/uniprot/P96878 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Sulfate_transp ^@ http://togogenome.org/gene/83332:Rv1072 ^@ http://purl.uniprot.org/uniprot/O53420 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3176c ^@ http://purl.uniprot.org/uniprot/Q6MX03 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv1905c ^@ http://purl.uniprot.org/uniprot/P9WP27 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable D-amino-acid oxidase ^@ http://purl.uniprot.org/annotation/PRO_0000390617 http://togogenome.org/gene/83332:Rv3089 ^@ http://purl.uniprot.org/uniprot/P9WQ37 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Alteration of the strength of the membrane binding; when associated with A-17; A-195; A-195 and A-197.|||Alteration of the strength of the membrane binding; when associated with A-9; A-17; A-195 and A-244.|||Alteration of the strength of the membrane binding; when associated with A-9; A-17; A-197 and A-244.|||Alteration of the strength of the membrane binding; when associated with A-9; A-195; A-197 and A-244.|||Does not show activity with small, medium or long acyl chains.|||Long-chain-fatty-acid--CoA ligase FadD13|||No effect on the formation of acyl-adenylate intermediate. However, it shows very poor catalytic efficiency to form acyl-CoA.|||Reduction of binding affinity for fatty acids.|||Shows a marked decrease in the activity with lauric and palmitic acid (C12 and C16 fatty acid) with a simultaneous increase in the activity with caprylic acid (C8 fatty acid).|||Slight increase of the fatty acyl-CoA ligase activity. Reduced rate of proteolytic degradation.|||Slight reduction of the fatty acyl-CoA ligase activity. Enhanced affinity towards palmitic acid binding.|||Slight reduction of the fatty acyl-CoA ligase activity. Slight increase of susceptibility to proteolysis.|||Strong reduction of the fatty acyl-CoA ligase activity. Enhanced affinity towards palmitic acid binding. No significant change in the total expression level, however the cytoplasmic expression is low. Slight increase of susceptibility to proteolysis.|||Strong reduction of the fatty acyl-CoA ligase activity. No significant change in the total expression level, however the cytoplasmic expression is reduced.|||Strong reduction of the fatty acyl-CoA ligase activity. No significant change in the total expression level, however the cytoplasmic expression is reduced. Slight increase of susceptibility to proteolysis.|||Strong reduction of the fatty acyl-CoA ligase activity. Reduction of binding affinity for ATP. ^@ http://purl.uniprot.org/annotation/PRO_0000420960 http://togogenome.org/gene/83332:Rv1719 ^@ http://purl.uniprot.org/uniprot/P71977 ^@ Region ^@ Domain Extent ^@ HTH cro/C1-type|||HTH iclR-type|||IclR-ED ^@ http://togogenome.org/gene/83332:Rv2904c ^@ http://purl.uniprot.org/uniprot/P9WHC9 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L19 ^@ http://purl.uniprot.org/annotation/PRO_0000163494 http://togogenome.org/gene/83332:Rv2570 ^@ http://purl.uniprot.org/uniprot/P9WL91 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2570 ^@ http://purl.uniprot.org/annotation/PRO_0000104050 http://togogenome.org/gene/83332:Rv3402c ^@ http://purl.uniprot.org/uniprot/P9WGJ7 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N6-(pyridoxal phosphate)lysine|||Protein Rv3402c ^@ http://purl.uniprot.org/annotation/PRO_0000104122 http://togogenome.org/gene/83332:Rv0641 ^@ http://purl.uniprot.org/uniprot/P9WHC7 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L1 ^@ http://purl.uniprot.org/annotation/PRO_0000125697 http://togogenome.org/gene/83332:Rv0112 ^@ http://purl.uniprot.org/uniprot/O53634 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ NAD(P)-bd_dom|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv1875 ^@ http://purl.uniprot.org/uniprot/O07754 ^@ Region ^@ Domain Extent ^@ Putative_PNPOx ^@ http://togogenome.org/gene/83332:Rv3588c ^@ http://purl.uniprot.org/uniprot/P9WPJ9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Carbonic anhydrase 2 ^@ http://purl.uniprot.org/annotation/PRO_0000396117 http://togogenome.org/gene/83332:Rv3219 ^@ http://purl.uniprot.org/uniprot/P9WF43 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mass|||Mutagenesis Site|||Strand ^@ 4Fe-4S Wbl-type|||Does not bind 4Fe-4S cluster, binds DNA.|||For fully alkylated recombinant protein tagged at both termini.|||Fully oxidized recombinant protein tagged at both termini.|||Loss of 4Fe-4S cluster, loss of DNA-binding.|||Loss of DNA-binding, still binds 4Fe-4S cluster.|||No change in 4Fe-4S cluster, binds DNA.|||Still binds DNA.|||Transcriptional regulator WhiB1 ^@ http://purl.uniprot.org/annotation/PRO_0000420379 http://togogenome.org/gene/83332:Rv1302 ^@ http://purl.uniprot.org/uniprot/P9WMW5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Decaprenyl-phosphate N-acetylglucosaminephosphotransferase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000108951 http://togogenome.org/gene/83332:Rv3368c ^@ http://purl.uniprot.org/uniprot/O50397 ^@ Region ^@ Domain Extent ^@ Nitroreductase ^@ http://togogenome.org/gene/83332:Rv1270c ^@ http://purl.uniprot.org/uniprot/P9WK55 ^@ Experimental Information|||Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Mutagenesis Site|||Signal Peptide ^@ Lipoprotein LprA|||N-palmitoyl cysteine|||S-diacylglycerol cysteine|||When expressed from this site no longer acts as a TLR2 agonist, suggests active protein is acylated. No glycosylated form detected. ^@ http://purl.uniprot.org/annotation/PRO_0000018135 http://togogenome.org/gene/83332:Rv1028A ^@ http://purl.uniprot.org/uniprot/Q79FT7 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2131c ^@ http://purl.uniprot.org/uniprot/P9WKJ1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Mass|||Mutagenesis Site|||Strand|||Turn ^@ 3'-phosphoadenosine 5'-phosphate phosphatase|||Less than 2% of wild-type IMPase and FBPase activities.|||Less than 3% of wild-type IMPase and FBPase activities.|||No effect on IMPase and FBPase activities. Much less sensitive to inhibition by Li(+).|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000142551 http://togogenome.org/gene/83332:Rv0759c ^@ http://purl.uniprot.org/uniprot/P9WML3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Motif ^@ HIT|||Histidine triad motif|||Uncharacterized HIT-like protein Rv0759c ^@ http://purl.uniprot.org/annotation/PRO_0000109825 http://togogenome.org/gene/83332:Rv0230c ^@ http://purl.uniprot.org/uniprot/P9WHN9 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-carboxylysine|||Phosphotriesterase homology protein|||via carbamate group ^@ http://purl.uniprot.org/annotation/PRO_0000205363 http://togogenome.org/gene/83332:Rv3890c ^@ http://purl.uniprot.org/uniprot/P9WNI1 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxC ^@ http://purl.uniprot.org/annotation/PRO_0000167818 http://togogenome.org/gene/83332:Rv1099c ^@ http://purl.uniprot.org/uniprot/P9WN21 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Initiator Methionine|||Modified Residue ^@ Fructose-1,6-bisphosphatase class 2|||N-acetylthreonine; partial|||Polar residues|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000403673 http://togogenome.org/gene/83332:Rv2795c ^@ http://purl.uniprot.org/uniprot/I6YEE1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ [Acyl-carrier-protein] phosphodiesterase PptH ^@ http://purl.uniprot.org/annotation/PRO_0000451443 http://togogenome.org/gene/83332:Rv0059 ^@ http://purl.uniprot.org/uniprot/O53604 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ DNA ADP-ribosyl transferase|||DarT|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000456050 http://togogenome.org/gene/83332:Rv2267c ^@ http://purl.uniprot.org/uniprot/P9WLG1 ^@ Molecule Processing ^@ Chain ^@ Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3 ^@ http://purl.uniprot.org/annotation/PRO_0000103993 http://togogenome.org/gene/83332:Rv0586 ^@ http://purl.uniprot.org/uniprot/P9WMG5 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH gntR-type|||HTH-type transcriptional regulator Mce2R ^@ http://purl.uniprot.org/annotation/PRO_0000050699 http://togogenome.org/gene/83332:Rv0903c ^@ http://purl.uniprot.org/uniprot/P9WGM1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||DNA Binding|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ 4-aspartylphosphate|||Loss of phosphorylation by PknG/PknK/PknJ.|||Loss of phosphorylation by PrrB.|||OmpR/PhoB-type|||Phosphothreonine|||Response regulatory|||Transcriptional regulatory protein PrrA ^@ http://purl.uniprot.org/annotation/PRO_0000081327 http://togogenome.org/gene/83332:Rv0552 ^@ http://purl.uniprot.org/uniprot/O06418 ^@ Region ^@ Domain Extent ^@ Amidohydro_3 ^@ http://togogenome.org/gene/83332:Rv2093c ^@ http://purl.uniprot.org/uniprot/P9WG97 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Sec-independent protein translocase protein TatC ^@ http://purl.uniprot.org/annotation/PRO_0000098090 http://togogenome.org/gene/83332:Rv3221A ^@ http://purl.uniprot.org/uniprot/P9WJ69 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Modified Residue|||Mutagenesis Site ^@ Anti-sigma factor RshA|||No in vitro phosphorylation by PknB.|||Phosphothreonine ^@ http://purl.uniprot.org/annotation/PRO_0000423650 http://togogenome.org/gene/83332:Rv0724 ^@ http://purl.uniprot.org/uniprot/P95072 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ Nucleophile|||Peptidase_S49|||Proton donor/acceptor ^@ http://togogenome.org/gene/83332:Rv0297 ^@ http://purl.uniprot.org/uniprot/Q6MX50 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS5|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000445087 http://togogenome.org/gene/83332:Rv1221 ^@ http://purl.uniprot.org/uniprot/P9WGG7 ^@ Molecule Processing|||Natural Variation|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif|||Splice Variant|||Strand ^@ ECF RNA polymerase sigma factor SigE|||H-T-H motif|||In isoform 2.|||In isoform 3.|||Polymerase core binding ^@ http://purl.uniprot.org/annotation/PRO_0000422945|||http://purl.uniprot.org/annotation/VSP_047440|||http://purl.uniprot.org/annotation/VSP_047441|||http://purl.uniprot.org/annotation/VSP_047442|||http://purl.uniprot.org/annotation/VSP_047443 http://togogenome.org/gene/83332:Rv2915c ^@ http://purl.uniprot.org/uniprot/P9WL23 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2915c ^@ http://purl.uniprot.org/annotation/PRO_0000104101 http://togogenome.org/gene/83332:Rv2395 ^@ http://purl.uniprot.org/uniprot/P71749 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3048c ^@ http://purl.uniprot.org/uniprot/P9WH71 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Turn ^@ Ribonucleoside-diphosphate reductase subunit beta nrdF2 ^@ http://purl.uniprot.org/annotation/PRO_0000393356 http://togogenome.org/gene/83332:Rv2740 ^@ http://purl.uniprot.org/uniprot/O33283 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ Epoxide hydrolase EphG|||Proton acceptor|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000420415 http://togogenome.org/gene/83332:Rv2215 ^@ http://purl.uniprot.org/uniprot/P9WIS7 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex|||Lipoyl-binding 1|||Lipoyl-binding 2|||N-acetylalanine|||N6-lipoyllysine|||Peripheral subunit-binding (PSBD)|||Pro residues|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000162266 http://togogenome.org/gene/83332:Rv3050c ^@ http://purl.uniprot.org/uniprot/I6XG13 ^@ Region ^@ DNA Binding|||Domain Extent|||Transmembrane ^@ H-T-H motif|||HTH tetR-type|||Helical ^@ http://togogenome.org/gene/83332:Rv1144 ^@ http://purl.uniprot.org/uniprot/P9WGQ7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv1144 ^@ http://purl.uniprot.org/annotation/PRO_0000415506 http://togogenome.org/gene/83332:Rv2885c ^@ http://purl.uniprot.org/uniprot/P9WL37 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Putative RNA-guided DNA endonuclease Rv2885c ^@ http://purl.uniprot.org/annotation/PRO_0000014146 http://togogenome.org/gene/83332:Rv3732 ^@ http://purl.uniprot.org/uniprot/O69699 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical ^@ http://purl.uniprot.org/annotation/PRO_5010314128 http://togogenome.org/gene/83332:Rv0241c ^@ http://purl.uniprot.org/uniprot/O53664 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ 3-hydroxyacyl-thioester dehydratase X|||MaoC-like ^@ http://purl.uniprot.org/annotation/PRO_0000448719 http://togogenome.org/gene/83332:Rv1794 ^@ http://purl.uniprot.org/uniprot/O53943 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ ESX-5 secretion-associated protein EspG5 ^@ http://purl.uniprot.org/annotation/PRO_0000435131 http://togogenome.org/gene/83332:Rv3556c ^@ http://purl.uniprot.org/uniprot/I6XHJ3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Acyl-thioester intermediate|||Proton acceptor|||Steroid 3-ketoacyl-CoA thiolase FadA6 ^@ http://purl.uniprot.org/annotation/PRO_0000452312 http://togogenome.org/gene/83332:Rv0071 ^@ http://purl.uniprot.org/uniprot/O53616 ^@ Region ^@ Domain Extent ^@ Reverse transcriptase ^@ http://togogenome.org/gene/83332:Rv1260 ^@ http://purl.uniprot.org/uniprot/P9WM51 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1260 ^@ http://purl.uniprot.org/annotation/PRO_0000103777 http://togogenome.org/gene/83332:Rv1614 ^@ http://purl.uniprot.org/uniprot/P9WK93 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical|||Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase ^@ http://purl.uniprot.org/annotation/PRO_0000172639 http://togogenome.org/gene/83332:Rv2995c ^@ http://purl.uniprot.org/uniprot/P9WKK9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ 3-isopropylmalate dehydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000083803 http://togogenome.org/gene/83332:Rv1083 ^@ http://purl.uniprot.org/uniprot/O53431 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv0382c ^@ http://purl.uniprot.org/uniprot/P9WHK9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Orotate phosphoribosyltransferase|||in other chain ^@ http://purl.uniprot.org/annotation/PRO_0000110712 http://togogenome.org/gene/83332:Rv1915 ^@ http://purl.uniprot.org/uniprot/O07718 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Putative isocitrate lyase subunit A ^@ http://purl.uniprot.org/annotation/PRO_0000432566 http://togogenome.org/gene/83332:Rv1729c ^@ http://purl.uniprot.org/uniprot/P9WFH9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv1729c ^@ http://purl.uniprot.org/annotation/PRO_0000361237 http://togogenome.org/gene/83332:Rv2581c ^@ http://purl.uniprot.org/uniprot/P9WMW3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized protein Rv2581c ^@ http://purl.uniprot.org/annotation/PRO_0000192361 http://togogenome.org/gene/83332:Rv2225 ^@ http://purl.uniprot.org/uniprot/P9WIL7 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Mass|||Modified Residue|||Strand|||Turn ^@ 3-methyl-2-oxobutanoate hydroxymethyltransferase|||N-acetylserine|||Proton acceptor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000184864 http://togogenome.org/gene/83332:Rv3412 ^@ http://purl.uniprot.org/uniprot/P9WKY9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3412 ^@ http://purl.uniprot.org/annotation/PRO_0000104130 http://togogenome.org/gene/83332:Rv0652 ^@ http://purl.uniprot.org/uniprot/P9WHE3 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L7/L12 ^@ http://purl.uniprot.org/annotation/PRO_0000157550 http://togogenome.org/gene/83332:Rv3785 ^@ http://purl.uniprot.org/uniprot/P9WKX1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3785 ^@ http://purl.uniprot.org/annotation/PRO_0000104148 http://togogenome.org/gene/83332:Rv2412 ^@ http://purl.uniprot.org/uniprot/P9WH41 ^@ Molecule Processing ^@ Chain ^@ 30S ribosomal protein S20 ^@ http://purl.uniprot.org/annotation/PRO_0000167997 http://togogenome.org/gene/83332:Rv1885c ^@ http://purl.uniprot.org/uniprot/P9WIB9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Mutagenesis Site|||Signal Peptide|||Turn ^@ 10% of the wild-type enzyme activity.|||20% of the wild-type enzyme activity.|||40% of the wild-type enzyme activity at pH 7.5 and 27% of the wild-type enzyme activity at pH 4.|||Chorismate mutase|||Less than 1% of the wild-type enzyme activity.|||No effect on the enzyme activity.|||Secreted chorismate mutase ^@ http://purl.uniprot.org/annotation/PRO_0000414906 http://togogenome.org/gene/83332:Rv1395 ^@ http://purl.uniprot.org/uniprot/P9WMJ1 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH araC/xylS-type|||Uncharacterized HTH-type transcriptional regulator Rv1395 ^@ http://purl.uniprot.org/annotation/PRO_0000194624 http://togogenome.org/gene/83332:Rv3230c ^@ http://purl.uniprot.org/uniprot/P9WNE9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ 2Fe-2S ferredoxin-type|||FAD-binding FR-type|||NADPH oxidoreductase ^@ http://purl.uniprot.org/annotation/PRO_0000392678 http://togogenome.org/gene/83332:Rv0035 ^@ http://purl.uniprot.org/uniprot/L7N699 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ AMP-binding|||Polar residues ^@ http://togogenome.org/gene/83332:Rv1312 ^@ http://purl.uniprot.org/uniprot/P9WM29 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1312 ^@ http://purl.uniprot.org/annotation/PRO_0000103796 http://togogenome.org/gene/83332:Rv0959 ^@ http://purl.uniprot.org/uniprot/P9WKN1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Uncharacterized protein Rv0959 ^@ http://purl.uniprot.org/annotation/PRO_0000103753 http://togogenome.org/gene/83332:Rv2142c ^@ http://purl.uniprot.org/uniprot/P9WHG5 ^@ Molecule Processing ^@ Chain ^@ Toxin ParE2 ^@ http://purl.uniprot.org/annotation/PRO_0000408373 http://togogenome.org/gene/83332:Rv1093 ^@ http://purl.uniprot.org/uniprot/P9WGI9 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||Serine hydroxymethyltransferase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000113618 http://togogenome.org/gene/83332:Rv0770 ^@ http://purl.uniprot.org/uniprot/P9WNY3 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Uncharacterized oxidoreductase Rv0770 ^@ http://purl.uniprot.org/annotation/PRO_0000173069 http://togogenome.org/gene/83332:Rv3902c ^@ http://purl.uniprot.org/uniprot/O05443 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Immunity factor for TNT ^@ http://purl.uniprot.org/annotation/PRO_0000437788 http://togogenome.org/gene/83332:Rv2806 ^@ http://purl.uniprot.org/uniprot/I6YAA5 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0598c ^@ http://purl.uniprot.org/uniprot/P9WF83 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC27 ^@ http://purl.uniprot.org/annotation/PRO_0000407886 http://togogenome.org/gene/83332:Rv1433 ^@ http://purl.uniprot.org/uniprot/O06825 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Nucleophile|||Probable L,D-transpeptidase 3|||Proton donor/acceptor|||YkuD ^@ http://purl.uniprot.org/annotation/PRO_0000430335 http://togogenome.org/gene/83332:Rv3312A ^@ http://purl.uniprot.org/uniprot/P9WI87 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide ^@ Basic and acidic residues|||Pilin ^@ http://purl.uniprot.org/annotation/PRO_0000314591 http://togogenome.org/gene/83332:Rv3471c ^@ http://purl.uniprot.org/uniprot/O06336 ^@ Region ^@ Domain Extent ^@ Cupin type-1 ^@ http://togogenome.org/gene/83332:Rv2442c ^@ http://purl.uniprot.org/uniprot/P9WHC3 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L21 ^@ http://purl.uniprot.org/annotation/PRO_0000181010 http://togogenome.org/gene/83332:Rv1231c ^@ http://purl.uniprot.org/uniprot/O86314 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||Helical ^@ http://togogenome.org/gene/83332:Rv2925c ^@ http://purl.uniprot.org/uniprot/P9WH03 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Strand ^@ DRBM|||RNase III|||Ribonuclease 3 ^@ http://purl.uniprot.org/annotation/PRO_0000180413 http://togogenome.org/gene/83332:Rv2407 ^@ http://purl.uniprot.org/uniprot/P9WGZ5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Ribonuclease Z ^@ http://purl.uniprot.org/annotation/PRO_0000155879 http://togogenome.org/gene/83332:Rv1404 ^@ http://purl.uniprot.org/uniprot/P71672 ^@ Region ^@ Domain Extent ^@ HTH marR-type ^@ http://togogenome.org/gene/83332:Rv3118 ^@ http://purl.uniprot.org/uniprot/P0CG95|||http://purl.uniprot.org/uniprot/P0CG96 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Uncharacterized protein Rv0814c|||Uncharacterized protein Rv3118 ^@ http://purl.uniprot.org/annotation/PRO_0000396084|||http://purl.uniprot.org/annotation/PRO_0000396092 http://togogenome.org/gene/83332:Rv2752c ^@ http://purl.uniprot.org/uniprot/P9WGZ9 ^@ Experimental Information|||Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Crosslink|||Mutagenesis Site ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Ribonuclease J|||Significantly decreased beta-lactamase and RNase activity. ^@ http://purl.uniprot.org/annotation/PRO_0000395887 http://togogenome.org/gene/83332:Rv1897c ^@ http://purl.uniprot.org/uniprot/P9WNS9 ^@ Molecule Processing|||Region ^@ Chain|||Motif ^@ D-aminoacyl-tRNA deacylase|||Gly-cisPro motif, important for rejection of L-amino acids ^@ http://purl.uniprot.org/annotation/PRO_0000164562 http://togogenome.org/gene/83332:Rv3060c ^@ http://purl.uniprot.org/uniprot/P95098 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH gntR-type ^@ http://togogenome.org/gene/83332:Rv3602c ^@ http://purl.uniprot.org/uniprot/P9WIL5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Mass|||Modified Residue|||Mutagenesis Site|||Strand ^@ 50-fold reduction in activity and slight reduction in the affinity for beta-alanine. 30- and 40-fold decrease in adenylate formation and pantothenate formation, respectively.|||More than 1000-fold reduction in activity and 120-fold decrease in adenylate formation. The enzymatic activity and the affinity for beta-alanine can be increased 10- and 3-fold, respectively, by alkylation of cysteine of mutant C-160.|||More than 1000-fold reduction in activity and 45-fold decrease in adenylate formation.|||More than 1000-fold reduction in activity and 50-fold decrease in adenylate formation.|||More than 1000-fold reduction in activity and 50-fold decrease in the affinity for ATP.|||More than 1000-fold reduction in activity and 52-fold decrease in adenylate formation.|||More than 1000-fold reduction in activity and 60-fold decrease in adenylate formation. 10-fold decrease in the affinity for ATP.|||N-acetylthreonine|||No effect.|||Pantothenate synthetase|||Proton donor|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000128245 http://togogenome.org/gene/83332:Rv2896c ^@ http://purl.uniprot.org/uniprot/P9WL29 ^@ Molecule Processing ^@ Chain ^@ Putative DNA processing protein DprA ^@ http://purl.uniprot.org/annotation/PRO_0000104095 http://togogenome.org/gene/83332:Rv0792c ^@ http://purl.uniprot.org/uniprot/O86331 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH gntR-type ^@ http://togogenome.org/gene/83332:Rv3416 ^@ http://purl.uniprot.org/uniprot/P9WF41 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mass|||Mutagenesis Site ^@ 4Fe-4S Wbl-type|||Fully oxidized protein.|||Fully reduced protein.|||No 4Fe-4S cluster assembly, does not complement growth defects; when associated with A-23; A-56 and A-62.|||No 4Fe-4S cluster assembly, does not complement growth defects; when associated with A-33; A-53 and A-56.|||No 4Fe-4S cluster assembly, does not complement growth defects; when associated with A-33; A-53 and A-62.|||No 4Fe-4S cluster assembly, does not complement growth defects; when associated with A-53; A-56 and A-62.|||Redox- and pH-responsive transcriptional regulator WhiB3 ^@ http://purl.uniprot.org/annotation/PRO_0000420382 http://togogenome.org/gene/83332:Rv0293c ^@ http://purl.uniprot.org/uniprot/O53697 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv3744 ^@ http://purl.uniprot.org/uniprot/O69711 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||DNA Binding|||Domain Extent|||Mass|||Mutagenesis Site ^@ Does not affect activity and regulation by metal ions.|||H-T-H motif|||HTH arsR-type|||HTH-type transcriptional regulator NmtR|||No change in activity. Lack of regulation by metal ions. ^@ http://purl.uniprot.org/annotation/PRO_0000419179 http://togogenome.org/gene/83332:Rv0251c ^@ http://purl.uniprot.org/uniprot/O53673 ^@ Region ^@ Domain Extent ^@ SHSP ^@ http://togogenome.org/gene/83332:Rv3379c ^@ http://purl.uniprot.org/uniprot/O50408 ^@ Region ^@ Domain Extent ^@ Transket_pyr ^@ http://togogenome.org/gene/83332:Rv0622 ^@ http://purl.uniprot.org/uniprot/P96912 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DUF732|||Helical ^@ http://togogenome.org/gene/83332:Rv1812c ^@ http://purl.uniprot.org/uniprot/P9WJJ1 ^@ Molecule Processing ^@ Chain ^@ NADH dehydrogenase-like protein Rv1812c ^@ http://purl.uniprot.org/annotation/PRO_0000392911 http://togogenome.org/gene/83332:Rv3568c ^@ http://purl.uniprot.org/uniprot/P9WNW7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ Iron-dependent extradiol dioxygenase|||VOC 1|||VOC 2 ^@ http://purl.uniprot.org/annotation/PRO_0000404507 http://togogenome.org/gene/83332:Rv0434 ^@ http://purl.uniprot.org/uniprot/P96280 ^@ Region ^@ Domain Extent ^@ Lon N-terminal ^@ http://togogenome.org/gene/83332:Rv0081 ^@ http://purl.uniprot.org/uniprot/P9WMI7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Strand ^@ H-T-H motif|||HTH arsR-type|||Uncharacterized HTH-type transcriptional regulator Rv0081 ^@ http://purl.uniprot.org/annotation/PRO_0000392681 http://togogenome.org/gene/83332:Rv1625c ^@ http://purl.uniprot.org/uniprot/P9WQ35 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Abolishes homodimerization and strongly decreases enzyme activitywhen associated with E-296 and R-363.|||Adenylate cyclase|||Almost complete loss of enzyme activity.|||Almost no loss of activity.|||Cytoplasmic|||Decreased enzyme activity.|||Guanylate cyclase|||Helical|||Loss of activity.|||Promotes formation of a domain-swapped dimer. Abolishes homodimerization and strongly decreases enzyme activity; when associated with E-296 and C-365.|||Strongly decreased enzyme activity. Abolishes homodimerization and strongly decreases enzyme activity; when associated with R-363 and C-365. ^@ http://purl.uniprot.org/annotation/PRO_0000195727 http://togogenome.org/gene/83332:Rv3007c ^@ http://purl.uniprot.org/uniprot/O53254 ^@ Region ^@ Domain Extent ^@ Flavin_Reduct ^@ http://togogenome.org/gene/83332:Rv0258c ^@ http://purl.uniprot.org/uniprot/P95215 ^@ Region ^@ Domain Extent ^@ TetR_C_16 ^@ http://togogenome.org/gene/83332:Rv0470c ^@ http://purl.uniprot.org/uniprot/P9WPB3 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Cyclopropane mycolic acid synthase 3|||Loss of phosphorylation; when associated with A-168.|||Loss of phosphorylation; when associated with A-183.|||N-acetylserine|||Phosphothreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000398358 http://togogenome.org/gene/83332:Rv0735 ^@ http://purl.uniprot.org/uniprot/P9WGH5 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Helix|||Motif|||Strand ^@ ECF RNA polymerase sigma factor SigL|||H-T-H motif|||Interaction with polymerase core subunit RpoC ^@ http://purl.uniprot.org/annotation/PRO_0000423646 http://togogenome.org/gene/83332:Rv2452c ^@ http://purl.uniprot.org/uniprot/O53179 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Secreted protein ^@ http://purl.uniprot.org/annotation/PRO_5030174832 http://togogenome.org/gene/83332:Rv1739c ^@ http://purl.uniprot.org/uniprot/P9WGF7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Helical|||Probable sulfate transporter Rv1739c|||STAS ^@ http://purl.uniprot.org/annotation/PRO_0000393282 http://togogenome.org/gene/83332:Rv2592c ^@ http://purl.uniprot.org/uniprot/P9WGW1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Holliday junction ATP-dependent DNA helicase RuvB ^@ http://purl.uniprot.org/annotation/PRO_0000165562 http://togogenome.org/gene/83332:Rv2236c ^@ http://purl.uniprot.org/uniprot/P9WP93 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Cobalamin biosynthesis protein CobD|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000150933 http://togogenome.org/gene/83332:Rv0662c ^@ http://purl.uniprot.org/uniprot/O06777 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB7 ^@ http://purl.uniprot.org/annotation/PRO_0000408055 http://togogenome.org/gene/83332:Rv3795 ^@ http://purl.uniprot.org/uniprot/P9WNL7 ^@ Experimental Information|||Molecule Processing|||Natural Variation|||Region|||Secondary Structure ^@ Chain|||Helix|||Sequence Conflict|||Sequence Variant|||Strand|||Transmembrane|||Turn ^@ Helical|||Probable arabinosyltransferase B|||Resistance to EMB. ^@ http://purl.uniprot.org/annotation/PRO_0000220569 http://togogenome.org/gene/83332:Rv1489 ^@ http://purl.uniprot.org/uniprot/L7N692 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3248c ^@ http://purl.uniprot.org/uniprot/P9WGV3 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Crosslink|||Helix|||Strand|||Turn ^@ Adenosylhomocysteinase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000116971 http://togogenome.org/gene/83332:Rv0105c ^@ http://purl.uniprot.org/uniprot/P9WHB1 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L28-1 ^@ http://purl.uniprot.org/annotation/PRO_0000178512 http://togogenome.org/gene/83332:Rv1322 ^@ http://purl.uniprot.org/uniprot/P9WM27 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1322 ^@ http://purl.uniprot.org/annotation/PRO_0000103802 http://togogenome.org/gene/83332:Rv2713 ^@ http://purl.uniprot.org/uniprot/P9WHH5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable soluble pyridine nucleotide transhydrogenase ^@ http://purl.uniprot.org/annotation/PRO_0000068065 http://togogenome.org/gene/83332:Rv1195 ^@ http://purl.uniprot.org/uniprot/Q79FR3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE family protein PE13 ^@ http://purl.uniprot.org/annotation/PRO_5007710417 http://togogenome.org/gene/83332:Rv3913 ^@ http://purl.uniprot.org/uniprot/P9WHH1 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Disulfide Bond|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Sequence Conflict|||Strand|||Turn ^@ N-acetylthreonine|||Phosphotyrosine; by PtkA|||Redox-active|||Removed|||Significantly reduces phosphorylation.|||Thioredoxin reductase ^@ http://purl.uniprot.org/annotation/PRO_0000166741 http://togogenome.org/gene/83332:Rv0780 ^@ http://purl.uniprot.org/uniprot/P9WHN1 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Sequence Conflict ^@ Phosphoribosylaminoimidazole-succinocarboxamide synthase ^@ http://purl.uniprot.org/annotation/PRO_0000100843 http://togogenome.org/gene/83332:Rv2540c ^@ http://purl.uniprot.org/uniprot/P9WPY1 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Chorismate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000140615 http://togogenome.org/gene/83332:Rv1635c ^@ http://purl.uniprot.org/uniprot/O06152 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||PMT_2 ^@ http://togogenome.org/gene/83332:Rv0609 ^@ http://purl.uniprot.org/uniprot/P9WF81 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC28 ^@ http://purl.uniprot.org/annotation/PRO_0000221197 http://togogenome.org/gene/83332:Rv1444c ^@ http://purl.uniprot.org/uniprot/O06815 ^@ Region ^@ Coiled-Coil ^@ ^@ http://togogenome.org/gene/83332:Rv3382c ^@ http://purl.uniprot.org/uniprot/P9WKF9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000128842 http://togogenome.org/gene/83332:Rv0406c ^@ http://purl.uniprot.org/uniprot/O86336 ^@ Region ^@ Domain Extent ^@ Lactamase_B ^@ http://togogenome.org/gene/83332:Rv1274 ^@ http://purl.uniprot.org/uniprot/P9WK53 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine; alternate|||Putative lipoprotein LprB|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018138 http://togogenome.org/gene/83332:Rv3486 ^@ http://purl.uniprot.org/uniprot/O06349 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein Rv3486 ^@ http://purl.uniprot.org/annotation/PRO_0000432510 http://togogenome.org/gene/83332:Rv1586c ^@ http://purl.uniprot.org/uniprot/O06604 ^@ Region ^@ Domain Extent ^@ Recombinase|||Resolvase/invertase-type recombinase catalytic ^@ http://togogenome.org/gene/83332:Rv1749c ^@ http://purl.uniprot.org/uniprot/O65935 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1241 ^@ http://purl.uniprot.org/uniprot/O50456 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB33 ^@ http://purl.uniprot.org/annotation/PRO_0000408077 http://togogenome.org/gene/83332:Rv2935 ^@ http://purl.uniprot.org/uniprot/P9WQE1 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Initiator Methionine|||Modified Residue ^@ Carrier|||For beta-ketoacyl synthase activity|||For malonyltransferase activity|||Ketosynthase family 3 (KS3)|||N-acetylserine|||O-(pantetheine 4'-phosphoryl)serine|||Phenolphthiocerol/phthiocerol polyketide synthase subunit E|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000406952 http://togogenome.org/gene/83332:Rv1942c ^@ http://purl.uniprot.org/uniprot/P95272 ^@ Molecule Processing ^@ Chain ^@ Probable endoribonuclease MazF5 ^@ http://purl.uniprot.org/annotation/PRO_0000406307 http://togogenome.org/gene/83332:Rv1414 ^@ http://purl.uniprot.org/uniprot/P9WLY3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1414 ^@ http://purl.uniprot.org/annotation/PRO_0000103841 http://togogenome.org/gene/83332:Rv2763c ^@ http://purl.uniprot.org/uniprot/P9WNX1 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ DHFR|||Dihydrofolate reductase ^@ http://purl.uniprot.org/annotation/PRO_0000186400 http://togogenome.org/gene/83332:Rv3615c ^@ http://purl.uniprot.org/uniprot/P9WJD7 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ ESX-1 secretion-associated protein EspC|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000104138 http://togogenome.org/gene/83332:Rv2560 ^@ http://purl.uniprot.org/uniprot/P9WLA1 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||Uncharacterized protein Rv2560 ^@ http://purl.uniprot.org/annotation/PRO_0000104041 http://togogenome.org/gene/83332:Rv3428c ^@ http://purl.uniprot.org/uniprot/Q50700 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Integrase catalytic|||Putative transposase Rv3428c ^@ http://purl.uniprot.org/annotation/PRO_0000075471 http://togogenome.org/gene/83332:Rv3756c ^@ http://purl.uniprot.org/uniprot/O69722 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv1531 ^@ http://purl.uniprot.org/uniprot/O53905 ^@ Region ^@ Domain Extent ^@ CMD ^@ http://togogenome.org/gene/83332:Rv0446c ^@ http://purl.uniprot.org/uniprot/O53731 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||S5A_REDUCTASE ^@ http://togogenome.org/gene/83332:Rv3579c ^@ http://purl.uniprot.org/uniprot/P9WFY5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Uncharacterized tRNA/rRNA methyltransferase Rv3579c ^@ http://purl.uniprot.org/annotation/PRO_0000379581 http://togogenome.org/gene/83332:Rv0926c ^@ http://purl.uniprot.org/uniprot/I6WZS8 ^@ Region ^@ Domain Extent ^@ DAP_DH_C ^@ http://togogenome.org/gene/83332:Rv1117 ^@ http://purl.uniprot.org/uniprot/O06569 ^@ Region ^@ Domain Extent ^@ ABM ^@ http://togogenome.org/gene/83332:Rv0536 ^@ http://purl.uniprot.org/uniprot/L7N670 ^@ Region ^@ Domain Extent ^@ Epimerase ^@ http://togogenome.org/gene/83332:Rv0749 ^@ http://purl.uniprot.org/uniprot/P9WF75 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC31 ^@ http://purl.uniprot.org/annotation/PRO_0000407888 http://togogenome.org/gene/83332:Rv2463 ^@ http://purl.uniprot.org/uniprot/O53190 ^@ Region ^@ Domain Extent ^@ Beta-lactamase ^@ http://togogenome.org/gene/83332:Rv1596 ^@ http://purl.uniprot.org/uniprot/P9WJJ7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Nicotinate-nucleotide pyrophosphorylase [carboxylating] ^@ http://purl.uniprot.org/annotation/PRO_0000155946 http://togogenome.org/gene/83332:Rv1937 ^@ http://purl.uniprot.org/uniprot/P95277 ^@ Region ^@ Domain Extent ^@ 2Fe-2S ferredoxin-type|||FAD-binding FR-type ^@ http://togogenome.org/gene/83332:Rv0568 ^@ http://purl.uniprot.org/uniprot/P9WPM9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative cytochrome P450 135B1|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000052293 http://togogenome.org/gene/83332:Rv3703c ^@ http://purl.uniprot.org/uniprot/O69671 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Hercynine oxygenase ^@ http://purl.uniprot.org/annotation/PRO_0000413648 http://togogenome.org/gene/83332:Rv0931c ^@ http://purl.uniprot.org/uniprot/P9WI79 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Repeat|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ 2600-fold decrease in activity.|||Cytoplasmic|||Decreases activity and alters substrate specificity.|||Extracellular|||Helical|||Lack of activity.|||N-acetylserine|||NHL 1|||NHL 2|||NHL 3|||NHL 4|||NHL 5|||NHL 6|||Phosphothreonine; by autocatalysis|||Protein kinase|||Proton acceptor|||Removed|||Serine/threonine-protein kinase PknD ^@ http://purl.uniprot.org/annotation/PRO_0000171209 http://togogenome.org/gene/83332:Rv1424c ^@ http://purl.uniprot.org/uniprot/P9WLX7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1424c ^@ http://purl.uniprot.org/annotation/PRO_0000103847 http://togogenome.org/gene/83332:Rv2603c ^@ http://purl.uniprot.org/uniprot/P9WGA5 ^@ Molecule Processing ^@ Chain ^@ Probable transcriptional regulatory protein Rv2603c ^@ http://purl.uniprot.org/annotation/PRO_0000175853 http://togogenome.org/gene/83332:Rv3105c ^@ http://purl.uniprot.org/uniprot/P9WHG1 ^@ Modification|||Molecule Processing ^@ Chain|||Modified Residue ^@ N5-methylglutamine|||Peptide chain release factor 2 ^@ http://purl.uniprot.org/annotation/PRO_0000166832 http://togogenome.org/gene/83332:Rv2434c ^@ http://purl.uniprot.org/uniprot/P71915 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Cyclic nucleotide-binding|||Helical ^@ http://togogenome.org/gene/83332:Rv1600 ^@ http://purl.uniprot.org/uniprot/P9WML7 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ Histidinol-phosphate aminotransferase|||N6-(pyridoxal phosphate)lysine ^@ http://purl.uniprot.org/annotation/PRO_0000153397 http://togogenome.org/gene/83332:Rv0328 ^@ http://purl.uniprot.org/uniprot/O07252 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv3258c ^@ http://purl.uniprot.org/uniprot/O53351 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0162c ^@ http://purl.uniprot.org/uniprot/L7N6B3 ^@ Region ^@ Domain Extent ^@ Enoyl reductase (ER) ^@ http://togogenome.org/gene/83332:Rv2906c ^@ http://purl.uniprot.org/uniprot/P9WFY7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ tRNA (guanine-N(1)-)-methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000060410 http://togogenome.org/gene/83332:Rv0148 ^@ http://purl.uniprot.org/uniprot/P96825 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Proton acceptor|||Putative short-chain type dehydrogenase/reductase Rv0148 ^@ http://purl.uniprot.org/annotation/PRO_0000395884 http://togogenome.org/gene/83332:Rv1541c ^@ http://purl.uniprot.org/uniprot/P9WK41 ^@ Experimental Information|||Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Mutagenesis Site|||Signal Peptide ^@ Decreased apparent weight in M.smegmatis, a portion of the protein is protected from extracellular trypsin.|||Lipoprotein LprI|||N-palmitoyl cysteine|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018150 http://togogenome.org/gene/83332:Rv1333 ^@ http://purl.uniprot.org/uniprot/P9WM23 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized aminopeptidase Rv1333 ^@ http://purl.uniprot.org/annotation/PRO_0000103808 http://togogenome.org/gene/83332:Rv2723 ^@ http://purl.uniprot.org/uniprot/P9WG93 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized membrane protein Rv2723 ^@ http://purl.uniprot.org/annotation/PRO_0000103421 http://togogenome.org/gene/83332:Rv3075c ^@ http://purl.uniprot.org/uniprot/I6YF40 ^@ Region|||Site ^@ Binding Site|||Domain Extent ^@ HpcH_HpaI ^@ http://togogenome.org/gene/83332:Rv3591c ^@ http://purl.uniprot.org/uniprot/I6YGL1 ^@ Region ^@ Domain Extent ^@ AB hydrolase-1 ^@ http://togogenome.org/gene/83332:Rv3924c ^@ http://purl.uniprot.org/uniprot/P9WH93 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L34 ^@ http://purl.uniprot.org/annotation/PRO_0000187424 http://togogenome.org/gene/83332:Rv2550c ^@ http://purl.uniprot.org/uniprot/P9WJ45 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB20 ^@ http://purl.uniprot.org/annotation/PRO_0000408066 http://togogenome.org/gene/83332:Rv1456c ^@ http://purl.uniprot.org/uniprot/O53148 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2304c ^@ http://purl.uniprot.org/uniprot/P9WLD3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2304c ^@ http://purl.uniprot.org/annotation/PRO_0000104013 http://togogenome.org/gene/83332:Rv3496c ^@ http://purl.uniprot.org/uniprot/I6XHD6 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Mce4_CUP1|||MlaD|||Pro residues ^@ http://togogenome.org/gene/83332:Rv1284 ^@ http://purl.uniprot.org/uniprot/P9WPJ7 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ Beta-carbonic anhydrase 1|||N-acetylthreonine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000103784 http://togogenome.org/gene/83332:Rv2128 ^@ http://purl.uniprot.org/uniprot/O33262 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2141c ^@ http://purl.uniprot.org/uniprot/L7N684 ^@ Region ^@ Domain Extent ^@ M20_dimer ^@ http://togogenome.org/gene/83332:Rv2945c ^@ http://purl.uniprot.org/uniprot/P9WK65 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Lipid Binding|||Mass|||Signal Peptide|||Strand|||Turn ^@ Expressed in M.bovis, lipidated and glycosylated.|||N-palmitoyl cysteine|||Putative phthiocerol dimycocerosate transporter LppX|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018121 http://togogenome.org/gene/83332:Rv1800 ^@ http://purl.uniprot.org/uniprot/P9WI11 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE-PPE|||Uncharacterized PPE family protein PPE28 ^@ http://purl.uniprot.org/annotation/PRO_0000379111 http://togogenome.org/gene/83332:Rv1953 ^@ http://purl.uniprot.org/uniprot/P9WF99 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC14 ^@ http://purl.uniprot.org/annotation/PRO_0000407874 http://togogenome.org/gene/83332:Rv0305c ^@ http://purl.uniprot.org/uniprot/Q6MX48 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||PPE ^@ http://togogenome.org/gene/83332:Rv3627c ^@ http://purl.uniprot.org/uniprot/O06380 ^@ Molecule Processing|||Site ^@ Active Site|||Chain|||Signal Peptide ^@ Acyl-ester intermediate|||Carboxypeptidase Rv3627c|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_5004156985 http://togogenome.org/gene/83332:Rv2241 ^@ http://purl.uniprot.org/uniprot/P9WIS9 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Crosslink ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Polar residues|||Pyruvate dehydrogenase E1 component ^@ http://purl.uniprot.org/annotation/PRO_0000162246 http://togogenome.org/gene/83332:Rv1344 ^@ http://purl.uniprot.org/uniprot/P9WQF1 ^@ Experimental Information|||Modification|||Molecule Processing|||Region ^@ Chain|||Domain Extent|||Modified Residue|||Mutagenesis Site ^@ Acyl carrier protein MbtL|||Carrier|||Lack of phosphopantetheinylation.|||O-(pantetheine 4'-phosphoryl)serine ^@ http://purl.uniprot.org/annotation/PRO_0000180269 http://togogenome.org/gene/83332:Rv2572c ^@ http://purl.uniprot.org/uniprot/P9WFW3 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Aspartate--tRNA(Asp/Asn) ligase ^@ http://purl.uniprot.org/annotation/PRO_0000110908 http://togogenome.org/gene/83332:Rv0317c ^@ http://purl.uniprot.org/uniprot/O07244 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Initiator Methionine ^@ GP-PDE|||Probable glycerophosphodiester phosphodiesterase 2|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000455760 http://togogenome.org/gene/83332:Rv3766 ^@ http://purl.uniprot.org/uniprot/O69731 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3766 ^@ http://purl.uniprot.org/annotation/PRO_0000432523 http://togogenome.org/gene/83332:Rv1361c ^@ http://purl.uniprot.org/uniprot/P9WI25 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE19 ^@ http://purl.uniprot.org/annotation/PRO_0000217845 http://togogenome.org/gene/83332:Rv2212 ^@ http://purl.uniprot.org/uniprot/P9WMU7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Guanylate cyclase|||Uncharacterized protein Rv2212 ^@ http://purl.uniprot.org/annotation/PRO_0000074132 http://togogenome.org/gene/83332:Rv0974c ^@ http://purl.uniprot.org/uniprot/O86318 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ CoA carboxyltransferase C-terminal|||CoA carboxyltransferase N-terminal|||Probable biotin-dependent acyl-coenzyme A carboxylase beta2 subunit ^@ http://purl.uniprot.org/annotation/PRO_0000452369 http://togogenome.org/gene/83332:Rv0940c ^@ http://purl.uniprot.org/uniprot/P9WKP1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0940c ^@ http://purl.uniprot.org/annotation/PRO_0000103743 http://togogenome.org/gene/83332:Rv1640c ^@ http://purl.uniprot.org/uniprot/P9WFU7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||DNA Binding|||Transmembrane ^@ Helical|||Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX|||OB|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000152657 http://togogenome.org/gene/83332:Rv1128c ^@ http://purl.uniprot.org/uniprot/P9WM57 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1128c ^@ http://purl.uniprot.org/annotation/PRO_0000103769 http://togogenome.org/gene/83332:Rv1294 ^@ http://purl.uniprot.org/uniprot/P9WPX1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ ACT|||Homoserine dehydrogenase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000066702 http://togogenome.org/gene/83332:Rv1607 ^@ http://purl.uniprot.org/uniprot/O53910 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Na_Ca_ex ^@ http://togogenome.org/gene/83332:Rv3713 ^@ http://purl.uniprot.org/uniprot/I6XI14 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ GATase_3|||Nucleophile ^@ http://togogenome.org/gene/83332:Rv0944 ^@ http://purl.uniprot.org/uniprot/L0T864 ^@ Molecule Processing|||Region ^@ Chain|||Zinc Finger ^@ FPG-type|||Uncharacterized formamidopyrimidine-DNA glycosylase-like protein ^@ http://purl.uniprot.org/annotation/PRO_0000421384 http://togogenome.org/gene/83332:Rv1435c ^@ http://purl.uniprot.org/uniprot/O06823 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5004156960 http://togogenome.org/gene/83332:Rv1247c ^@ http://purl.uniprot.org/uniprot/O50462 ^@ Molecule Processing ^@ Chain ^@ Antitoxin RelB ^@ http://purl.uniprot.org/annotation/PRO_0000406201 http://togogenome.org/gene/83332:Rv1753c ^@ http://purl.uniprot.org/uniprot/P9WI15 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE24 ^@ http://purl.uniprot.org/annotation/PRO_0000378480 http://togogenome.org/gene/83332:Rv0339c ^@ http://purl.uniprot.org/uniprot/O33269 ^@ Region ^@ Domain Extent ^@ HTH luxR-type ^@ http://togogenome.org/gene/83332:Rv2090 ^@ http://purl.uniprot.org/uniprot/P9WNU3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ 5'-3' exonuclease ^@ http://purl.uniprot.org/annotation/PRO_0000101290 http://togogenome.org/gene/83332:Rv3814c ^@ http://purl.uniprot.org/uniprot/O07809 ^@ Region ^@ Domain Extent ^@ PlsC ^@ http://togogenome.org/gene/83332:Rv0265c ^@ http://purl.uniprot.org/uniprot/L7N6B2 ^@ Region ^@ Domain Extent ^@ Fe/B12 periplasmic-binding ^@ http://togogenome.org/gene/83332:Rv3270 ^@ http://purl.uniprot.org/uniprot/P9WPT5 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Mutagenesis Site|||Transmembrane ^@ 4-aspartylphosphate intermediate|||HMA|||Helical|||Loss of ATPase activity.|||Manganese-exporting P-type ATPase ^@ http://purl.uniprot.org/annotation/PRO_0000046337 http://togogenome.org/gene/83332:Rv2917 ^@ http://purl.uniprot.org/uniprot/P9WL21 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||Helicase ATP-binding|||Polar residues|||Uncharacterized protein Rv2917 ^@ http://purl.uniprot.org/annotation/PRO_0000104102 http://togogenome.org/gene/83332:Rv0163 ^@ http://purl.uniprot.org/uniprot/O07408 ^@ Region ^@ Domain Extent ^@ 4HBT ^@ http://togogenome.org/gene/83332:Rv1553 ^@ http://purl.uniprot.org/uniprot/P9WN89 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ 2Fe-2S ferredoxin-type|||4Fe-4S ferredoxin-type|||Fumarate reductase iron-sulfur subunit ^@ http://purl.uniprot.org/annotation/PRO_0000158705 http://togogenome.org/gene/83332:Rv3776 ^@ http://purl.uniprot.org/uniprot/P72042 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv3776 ^@ http://purl.uniprot.org/annotation/PRO_0000405540 http://togogenome.org/gene/83332:Rv2733c ^@ http://purl.uniprot.org/uniprot/P9WK05 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ MTTase N-terminal|||Radical SAM core|||TRAM|||tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase ^@ http://purl.uniprot.org/annotation/PRO_0000141745 http://togogenome.org/gene/83332:Rv3086 ^@ http://purl.uniprot.org/uniprot/P9WQB9 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative alcohol dehydrogenase D ^@ http://purl.uniprot.org/annotation/PRO_0000420879 http://togogenome.org/gene/83332:Rv3604c ^@ http://purl.uniprot.org/uniprot/O06278 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Basic and acidic residues|||DUF6779|||Helical|||Polar residues|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0458 ^@ http://purl.uniprot.org/uniprot/P9WNY1 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Probable aldehyde dehydrogenase|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000056449 http://togogenome.org/gene/83332:Rv3399 ^@ http://purl.uniprot.org/uniprot/P9WFH1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3399 ^@ http://purl.uniprot.org/annotation/PRO_0000104118 http://togogenome.org/gene/83332:Rv0637 ^@ http://purl.uniprot.org/uniprot/P9WFJ9 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ UPF0336 protein Rv0637 ^@ http://purl.uniprot.org/annotation/PRO_0000216144 http://togogenome.org/gene/83332:Rv0283 ^@ http://purl.uniprot.org/uniprot/P9WNR3 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Basic and acidic residues|||ESX-3 secretion system ATPase EccB3|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393230 http://togogenome.org/gene/83332:Rv1466 ^@ http://purl.uniprot.org/uniprot/O53157 ^@ Region ^@ Domain Extent ^@ FeS_assembly_P ^@ http://togogenome.org/gene/83332:Rv0097 ^@ http://purl.uniprot.org/uniprot/P9WG83 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative dioxygenase Rv0097 ^@ http://purl.uniprot.org/annotation/PRO_0000194020 http://togogenome.org/gene/83332:Rv3215 ^@ http://purl.uniprot.org/uniprot/P9WFW9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Proton donor|||Putative isochorismate synthase MenF ^@ http://purl.uniprot.org/annotation/PRO_0000399472 http://togogenome.org/gene/83332:Rv2316 ^@ http://purl.uniprot.org/uniprot/P71896 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||Helical ^@ http://togogenome.org/gene/83332:Rv3723 ^@ http://purl.uniprot.org/uniprot/O69690 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Acidic residues|||Basic residues|||Helical|||Lipid uptake coordinator A ^@ http://purl.uniprot.org/annotation/PRO_0000441801 http://togogenome.org/gene/83332:Rv0956 ^@ http://purl.uniprot.org/uniprot/P9WHM5 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Phosphoribosylglycinamide formyltransferase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000420698 http://togogenome.org/gene/83332:Rv0426c ^@ http://purl.uniprot.org/uniprot/P96272 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide|||Transmembrane ^@ Helical|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5010332139 http://togogenome.org/gene/83332:Rv2138 ^@ http://purl.uniprot.org/uniprot/O06237 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010252197 http://togogenome.org/gene/83332:Rv1963c ^@ http://purl.uniprot.org/uniprot/P95251 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type 1|||HTH tetR-type 2|||Transcriptional repressor Mce3R ^@ http://purl.uniprot.org/annotation/PRO_0000438536 http://togogenome.org/gene/83332:Rv2616 ^@ http://purl.uniprot.org/uniprot/O06198 ^@ Region ^@ Domain Extent ^@ DUF1990 ^@ http://togogenome.org/gene/83332:Rv2792c ^@ http://purl.uniprot.org/uniprot/I6YA93 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ O-(5'-phospho-DNA)-serine intermediate|||Resolvase/invertase-type recombinase catalytic ^@ http://togogenome.org/gene/83332:Rv2444c ^@ http://purl.uniprot.org/uniprot/P71905 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Acidic residues|||Basic and acidic residues|||Polar residues|||S1 motif ^@ http://togogenome.org/gene/83332:Rv1080c ^@ http://purl.uniprot.org/uniprot/P9WMT9 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Coiled-Coil|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||Removed|||Transcription elongation factor GreA ^@ http://purl.uniprot.org/annotation/PRO_0000176943 http://togogenome.org/gene/83332:Rv2251 ^@ http://purl.uniprot.org/uniprot/L0TBR2 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv2620c ^@ http://purl.uniprot.org/uniprot/I6Y9U6 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv3206c ^@ http://purl.uniprot.org/uniprot/P9WMN7 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ Cysteine persulfide intermediate; for sulfurtransferase activity|||Glycyl thioester intermediate; for adenylyltransferase activity|||Helical|||Probable adenylyltransferase/sulfurtransferase MoeZ|||Rhodanese ^@ http://purl.uniprot.org/annotation/PRO_0000401136 http://togogenome.org/gene/83332:Rv2583c ^@ http://purl.uniprot.org/uniprot/P9WHG9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand ^@ ACT|||Altered association with RAC components.|||Bifunctional (p)ppGpp synthase/hydrolase RelA|||HD|||Loss of hydrolytic activity.|||Loss of ppGpp synthase activity.|||Nucleophile, for hydrolase activity|||TGS ^@ http://purl.uniprot.org/annotation/PRO_0000166551 http://togogenome.org/gene/83332:Rv3096 ^@ http://purl.uniprot.org/uniprot/I6YB54 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ 1,4-beta-xylanase ^@ http://purl.uniprot.org/annotation/PRO_5010248535 http://togogenome.org/gene/83332:Rv3450c ^@ http://purl.uniprot.org/uniprot/P9WNR1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-4 secretion system ATPase EccB4|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393231 http://togogenome.org/gene/83332:Rv2079 ^@ http://purl.uniprot.org/uniprot/P9WLK7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2079 ^@ http://purl.uniprot.org/annotation/PRO_0000103951 http://togogenome.org/gene/83332:Rv1787 ^@ http://purl.uniprot.org/uniprot/P9WI13 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE25 ^@ http://purl.uniprot.org/annotation/PRO_0000379588 http://togogenome.org/gene/83332:Rv1430 ^@ http://purl.uniprot.org/uniprot/L7N697 ^@ Experimental Information|||Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent|||Mutagenesis Site|||Transmembrane ^@ Esterase PE16|||Helical|||Loss of activity.|||PE|||PE-PPE ^@ http://purl.uniprot.org/annotation/PRO_0000448332 http://togogenome.org/gene/83332:Rv3020c ^@ http://purl.uniprot.org/uniprot/Q6MX18 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ ESAT-6-like protein EsxS ^@ http://purl.uniprot.org/annotation/PRO_0000436932 http://togogenome.org/gene/83332:Rv0119 ^@ http://purl.uniprot.org/uniprot/O07169 ^@ Region ^@ Domain Extent ^@ AMP-binding|||AMP-binding_C ^@ http://togogenome.org/gene/83332:Rv0987 ^@ http://purl.uniprot.org/uniprot/O53900 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized ABC transporter permease protein Rv0987 ^@ http://purl.uniprot.org/annotation/PRO_0000451251 http://togogenome.org/gene/83332:Rv1478 ^@ http://purl.uniprot.org/uniprot/P9WHU5 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ Abolishes host cell invasion.|||NlpC/P60|||Nucleophile|||Peptidoglycan endopeptidase RipB|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000413763 http://togogenome.org/gene/83332:Rv1652 ^@ http://purl.uniprot.org/uniprot/P9WPZ9 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Strand|||Turn ^@ N-acetyl-gamma-glutamyl-phosphate reductase ^@ http://purl.uniprot.org/annotation/PRO_0000112424 http://togogenome.org/gene/83332:Rv1304 ^@ http://purl.uniprot.org/uniprot/P9WPV7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ATP synthase subunit a|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000082063 http://togogenome.org/gene/83332:Rv1617 ^@ http://purl.uniprot.org/uniprot/P9WKE5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Partial loss of phosphorylation. Decrease in activity.|||Phosphoserine; by PknJ; in vitro|||Pyruvate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000112082 http://togogenome.org/gene/83332:Rv2488c ^@ http://purl.uniprot.org/uniprot/O53213 ^@ Region ^@ Coiled-Coil|||Domain Extent ^@ Guanylate cyclase|||HTH luxR-type ^@ http://togogenome.org/gene/83332:Rv1446c ^@ http://purl.uniprot.org/uniprot/O06813 ^@ Region ^@ Domain Extent ^@ OpcA_G6PD_C|||OpcA_G6PD_assem ^@ http://togogenome.org/gene/83332:Rv2274c ^@ http://purl.uniprot.org/uniprot/P9WIH7 ^@ Molecule Processing ^@ Chain ^@ Putative toxin MazF8 ^@ http://purl.uniprot.org/annotation/PRO_0000104003 http://togogenome.org/gene/83332:Rv3137 ^@ http://purl.uniprot.org/uniprot/P95189 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Causes a probable loss of enzymatic activity.|||Histidinol-phosphatase ^@ http://purl.uniprot.org/annotation/PRO_0000404323 http://togogenome.org/gene/83332:Rv1257c ^@ http://purl.uniprot.org/uniprot/Q11061 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv2102 ^@ http://purl.uniprot.org/uniprot/O53500 ^@ Molecule Processing|||Region ^@ Chain|||Zinc Finger ^@ SWIM-type|||Uncharacterized protein Rv2102 ^@ http://purl.uniprot.org/annotation/PRO_0000432518 http://togogenome.org/gene/83332:Rv3280 ^@ http://purl.uniprot.org/uniprot/P9WQH7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Initiator Methionine|||Strand|||Turn ^@ Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit|||CoA carboxyltransferase C-terminal|||CoA carboxyltransferase N-terminal|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000199799 http://togogenome.org/gene/83332:Rv3825c ^@ http://purl.uniprot.org/uniprot/P9WQE9 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Modified Residue ^@ Acyl-ester intermediate; for acyltransferase activity|||Acyl-thioester intermediate; for beta-ketoacyl synthase activity|||Carrier|||For beta-ketoacyl synthase activity|||Ketosynthase family 3 (KS3)|||O-(pantetheine 4'-phosphoryl)serine|||Phthioceranic/hydroxyphthioceranic acid synthase|||Proton acceptor; for dehydratase activity|||Proton donor; for dehydratase activity ^@ http://purl.uniprot.org/annotation/PRO_0000329012 http://togogenome.org/gene/83332:Rv3462c ^@ http://purl.uniprot.org/uniprot/P9WKK3 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ S1-like|||Translation initiation factor IF-1 ^@ http://purl.uniprot.org/annotation/PRO_0000095828 http://togogenome.org/gene/83332:Rv1924c ^@ http://purl.uniprot.org/uniprot/P95289 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1566c ^@ http://purl.uniprot.org/uniprot/O06624 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ NlpC/P60|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5010288530 http://togogenome.org/gene/83332:Rv1736c ^@ http://purl.uniprot.org/uniprot/P9WJQ1 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ 4Fe-4S Mo/W bis-MGD-type|||Helical|||Nitrate reductase-like protein NarX|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000392915 http://togogenome.org/gene/83332:Rv2222c ^@ http://purl.uniprot.org/uniprot/P9WN37 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Crosslink|||Domain Extent ^@ GS beta-grasp|||GS catalytic|||Glutamine synthetase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000153247 http://togogenome.org/gene/83332:Rv3409c ^@ http://purl.uniprot.org/uniprot/P9WMV9 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Cholesterol oxidase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000405326 http://togogenome.org/gene/83332:Rv0648 ^@ http://purl.uniprot.org/uniprot/P96937 ^@ Region ^@ Domain Extent ^@ Alpha-mann_mid ^@ http://togogenome.org/gene/83332:Rv0295c ^@ http://purl.uniprot.org/uniprot/O53699 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Trehalose 2-sulfotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000434782 http://togogenome.org/gene/83332:Rv1152 ^@ http://purl.uniprot.org/uniprot/O06550 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH gntR-type ^@ http://togogenome.org/gene/83332:Rv2893 ^@ http://purl.uniprot.org/uniprot/I6YEN3 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv3770c ^@ http://purl.uniprot.org/uniprot/P72037 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0475 ^@ http://purl.uniprot.org/uniprot/P9WIP9 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Sequence Conflict ^@ Basic residues|||Heparin-binding hemagglutinin ^@ http://purl.uniprot.org/annotation/PRO_0000083910 http://togogenome.org/gene/83332:Rv3734c ^@ http://purl.uniprot.org/uniprot/P9WKC7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Probable diacyglycerol O-acyltransferase tgs2|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000222921 http://togogenome.org/gene/83332:Rv0436c ^@ http://purl.uniprot.org/uniprot/P9WPG1 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ CDP-diacylglycerol--serine O-phosphatidyltransferase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000056798 http://togogenome.org/gene/83332:Rv0966c ^@ http://purl.uniprot.org/uniprot/P9WKM1 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0966c ^@ http://purl.uniprot.org/annotation/PRO_0000103764 http://togogenome.org/gene/83332:Rv2352c ^@ http://purl.uniprot.org/uniprot/P9WHZ9 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE38 ^@ http://purl.uniprot.org/annotation/PRO_0000378482 http://togogenome.org/gene/83332:Rv3910 ^@ http://purl.uniprot.org/uniprot/P9WJK3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Abolishes phosphorylation by PknB.|||Basic and acidic residues|||Cytoplasmic|||Extracellular|||Helical|||N-acetylmethionine|||Phosphothreonine|||Polar residues|||Probable peptidoglycan biosynthesis protein MviN ^@ http://purl.uniprot.org/annotation/PRO_0000419663 http://togogenome.org/gene/83332:Rv2626c ^@ http://purl.uniprot.org/uniprot/P9WJA3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Disulfide Bond|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ CBS 1|||CBS 2|||Forms less stable dimer.|||Hypoxic response protein 1|||Interchain|||No longer forms SDS-resistant dimer. ^@ http://purl.uniprot.org/annotation/PRO_0000392622 http://togogenome.org/gene/83332:Rv1267c ^@ http://purl.uniprot.org/uniprot/P9WGJ9 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Abolished phosphorylation.|||Decreases phosphorylation by PknH.|||FHA|||OmpR/PhoB-type|||Transcriptional regulatory protein EmbR ^@ http://purl.uniprot.org/annotation/PRO_0000110008 http://togogenome.org/gene/83332:Rv1621c ^@ http://purl.uniprot.org/uniprot/O06138 ^@ Region ^@ Domain Extent|||Transmembrane ^@ ABC transmembrane type-1|||ABC transporter|||Helical ^@ http://togogenome.org/gene/83332:Rv2802c ^@ http://purl.uniprot.org/uniprot/P71649 ^@ Region ^@ Domain Extent ^@ DUF2293 ^@ http://togogenome.org/gene/83332:Rv2454c ^@ http://purl.uniprot.org/uniprot/O53181 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 2-oxoglutarate oxidoreductase subunit KorB|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000420517 http://togogenome.org/gene/83332:Rv3290c ^@ http://purl.uniprot.org/uniprot/P9WQ77 ^@ Modification|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Modified Residue|||Strand|||Turn ^@ N6-(pyridoxal phosphate)lysine|||Probable L-lysine-epsilon aminotransferase ^@ http://purl.uniprot.org/annotation/PRO_0000120512 http://togogenome.org/gene/83332:Rv1096 ^@ http://purl.uniprot.org/uniprot/O53444 ^@ Region ^@ Compositionally Biased Region|||Domain Extent|||Transmembrane ^@ Helical|||NodB homology|||Polar residues ^@ http://togogenome.org/gene/83332:Rv2264c ^@ http://purl.uniprot.org/uniprot/O53538 ^@ Region ^@ Compositionally Biased Region ^@ Pro residues ^@ http://togogenome.org/gene/83332:Rv2630 ^@ http://purl.uniprot.org/uniprot/P9WQ03 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Probable protein archease ^@ http://purl.uniprot.org/annotation/PRO_0000392933 http://togogenome.org/gene/83332:Rv3294c ^@ http://purl.uniprot.org/uniprot/L7N658 ^@ Region ^@ Domain Extent ^@ DUF4143 ^@ http://togogenome.org/gene/83332:Rv3107c ^@ http://purl.uniprot.org/uniprot/O05784 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv1806 ^@ http://purl.uniprot.org/uniprot/L7N656 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv2922c ^@ http://purl.uniprot.org/uniprot/P9WGF3 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Coiled-Coil|||Domain Extent ^@ Chromosome partition protein Smc|||SMC hinge ^@ http://purl.uniprot.org/annotation/PRO_0000119030 http://togogenome.org/gene/83332:Rv3419c ^@ http://purl.uniprot.org/uniprot/P9WHT7 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ tRNA N6-adenosine threonylcarbamoyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000096970 http://togogenome.org/gene/83332:Rv3111 ^@ http://purl.uniprot.org/uniprot/P9WJR9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Cyclic pyranopterin monophosphate synthase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000097810 http://togogenome.org/gene/83332:Rv2028c ^@ http://purl.uniprot.org/uniprot/P9WFD9 ^@ Molecule Processing ^@ Chain ^@ Universal stress protein Rv2028c ^@ http://purl.uniprot.org/annotation/PRO_0000392627 http://togogenome.org/gene/83332:Rv0998 ^@ http://purl.uniprot.org/uniprot/O05581 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Acetyltransferase Pat|||Completely abolishes the interaction with the aliphatic tail of the substrate lysine.|||Induces autoacetylation of the new lysine in the absence of cAMP.|||N-acetyltransferase|||Substantially decreases the interaction with the aliphatic tail of the substrate lysine.|||Substantially decreases the interaction with the aliphatic tail of the substrate lysine. Markedly reduced activity, with an altered pH-rate profile and abolishes direct interactions with R-184. ^@ http://purl.uniprot.org/annotation/PRO_0000420362 http://togogenome.org/gene/83332:Rv0131c ^@ http://purl.uniprot.org/uniprot/P96808 ^@ Region ^@ Domain Extent ^@ Acyl-CoA_dh_1|||Acyl-CoA_dh_M|||Acyl-CoA_dh_N ^@ http://togogenome.org/gene/83332:Rv0659c ^@ http://purl.uniprot.org/uniprot/P9WII1 ^@ Molecule Processing ^@ Chain ^@ Probable endoribonuclease MazF2 ^@ http://purl.uniprot.org/annotation/PRO_0000406305 http://togogenome.org/gene/83332:Rv2749 ^@ http://purl.uniprot.org/uniprot/O33291 ^@ Region ^@ Domain Extent ^@ ABM ^@ http://togogenome.org/gene/83332:Rv3239c ^@ http://purl.uniprot.org/uniprot/O05884 ^@ Region|||Site ^@ Active Site|||Domain Extent|||Motif|||Transmembrane ^@ Cyclic nucleotide-binding|||DGA/G|||GXGXXG|||GXSXG|||Helical|||MFS|||Nucleophile|||PNPLA|||Proton acceptor ^@ http://togogenome.org/gene/83332:Rv0485 ^@ http://purl.uniprot.org/uniprot/P9WKV1 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding ^@ H-T-H motif|||Transcriptional regulator Rv0485 ^@ http://purl.uniprot.org/annotation/PRO_0000103687 http://togogenome.org/gene/83332:Rv1662 ^@ http://purl.uniprot.org/uniprot/O65933 ^@ Region ^@ Domain Extent ^@ Dehydrogenase (DH)|||Enoyl reductase (ER)|||Ketosynthase (KS)|||Malonyl-CoA:ACP transacylase (MAT) ^@ http://togogenome.org/gene/83332:Rv1314c ^@ http://purl.uniprot.org/uniprot/P9WP99 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Corrinoid adenosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000103798 http://togogenome.org/gene/83332:Rv2149c ^@ http://purl.uniprot.org/uniprot/P9WKD5 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Purine nucleoside phosphorylase Rv2149c ^@ http://purl.uniprot.org/annotation/PRO_0000163166 http://togogenome.org/gene/83332:Rv2324 ^@ http://purl.uniprot.org/uniprot/P71888 ^@ Region ^@ Domain Extent ^@ HTH asnC-type ^@ http://togogenome.org/gene/83332:Rv1974 ^@ http://purl.uniprot.org/uniprot/O53975 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Signal Peptide ^@ DUF732 ^@ http://purl.uniprot.org/annotation/PRO_5010161308 http://togogenome.org/gene/83332:Rv2287 ^@ http://purl.uniprot.org/uniprot/P9WJI3 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized Na(+)/H(+) exchanger Rv2287 ^@ http://purl.uniprot.org/annotation/PRO_0000052400 http://togogenome.org/gene/83332:Rv0605 ^@ http://purl.uniprot.org/uniprot/I6Y890 ^@ Region|||Site ^@ Active Site|||Domain Extent ^@ O-(5'-phospho-DNA)-serine intermediate|||Resolvase/invertase-type recombinase catalytic ^@ http://togogenome.org/gene/83332:Rv3148 ^@ http://purl.uniprot.org/uniprot/P9WJH5 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylthreonine|||NADH-quinone oxidoreductase subunit D|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000118620 http://togogenome.org/gene/83332:Rv0078 ^@ http://purl.uniprot.org/uniprot/O53623 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv1782 ^@ http://purl.uniprot.org/uniprot/P9WNQ9 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Disulfide Bond|||Topological Domain|||Transmembrane ^@ Cytoplasmic|||ESX-5 secretion system ATPase EccB5|||Helical|||Periplasmic ^@ http://purl.uniprot.org/annotation/PRO_0000393232 http://togogenome.org/gene/83332:Rv2116 ^@ http://purl.uniprot.org/uniprot/P9WK75 ^@ Modification|||Molecule Processing ^@ Chain|||Lipid Binding|||Signal Peptide ^@ N-palmitoyl cysteine|||Putative lipoprotein LppK|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000018111 http://togogenome.org/gene/83332:Rv2641 ^@ http://purl.uniprot.org/uniprot/P9WIR5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Initiator Methionine ^@ Cadmium-induced protein CadI|||Removed|||VOC ^@ http://purl.uniprot.org/annotation/PRO_0000089275 http://togogenome.org/gene/83332:Rv0744c ^@ http://purl.uniprot.org/uniprot/O53807 ^@ Region ^@ Domain Extent ^@ HTH_17 ^@ http://togogenome.org/gene/83332:Rv1611 ^@ http://purl.uniprot.org/uniprot/P9WFX7 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Strand|||Turn ^@ Indole-3-glycerol phosphate synthase ^@ http://purl.uniprot.org/annotation/PRO_0000154234 http://togogenome.org/gene/83332:Rv3835 ^@ http://purl.uniprot.org/uniprot/P9WKW5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues|||Uncharacterized membrane protein Rv3835 ^@ http://purl.uniprot.org/annotation/PRO_0000390678 http://togogenome.org/gene/83332:Rv1578c ^@ http://purl.uniprot.org/uniprot/O06612 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv0467 ^@ http://purl.uniprot.org/uniprot/P9WKK7 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Adopts a conformation almost identical to the wild-type.|||Isocitrate lyase|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000068779 http://togogenome.org/gene/83332:Rv3159c ^@ http://purl.uniprot.org/uniprot/Q6MX04 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv1009 ^@ http://purl.uniprot.org/uniprot/A0A2Z3DFM7|||http://purl.uniprot.org/uniprot/P9WG29 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Disulfide Bond|||Domain Extent|||Helix|||Lipid Binding|||Non-terminal Residue|||Signal Peptide|||Strand|||Turn ^@ G5|||N-palmitoyl cysteine|||Resuscitation-promoting factor RpfB|||S-diacylglycerol cysteine ^@ http://purl.uniprot.org/annotation/PRO_0000421026|||http://purl.uniprot.org/annotation/PRO_5016455089 http://togogenome.org/gene/83332:Rv2232 ^@ http://purl.uniprot.org/uniprot/P9WPI9 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Compositionally Biased Region|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Decreases affinity for ATP and autophosphorylation efficiency.|||Decreases affinity for ATP and autophosphorylation efficiency. Decreases interaction with PtpA.|||Does not affect autophosphorylation.|||Lack of autophosphorylation. Decreases interaction with PtpA. Cannot phosphorylate and activate PtpA.|||Phosphotyrosine; by autocatalysis|||Polar residues|||Significant decrease in ATP binding affinity and autophosphorylation efficiency. Decreases interaction with PtpA.|||Tyrosine-protein kinase PtkA ^@ http://purl.uniprot.org/annotation/PRO_0000108066 http://togogenome.org/gene/83332:Rv0309 ^@ http://purl.uniprot.org/uniprot/O07236 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010328433 http://togogenome.org/gene/83332:Rv1162 ^@ http://purl.uniprot.org/uniprot/O06560 ^@ Region ^@ Domain Extent ^@ 4Fe-4S ferredoxin-type ^@ http://togogenome.org/gene/83332:Rv3780 ^@ http://purl.uniprot.org/uniprot/P9WKX3 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure ^@ Chain|||Helix|||Motif|||Mutagenesis Site|||Strand ^@ Bacterial proteasome activator|||HbYX motif|||Loss of interaction with the proteasome subunit PrcA. ^@ http://purl.uniprot.org/annotation/PRO_0000104145 http://togogenome.org/gene/83332:Rv2903c ^@ http://purl.uniprot.org/uniprot/P9WKA1 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Compositionally Biased Region|||Topological Domain|||Transmembrane ^@ Basic and acidic residues|||Cytoplasmic|||Extracellular|||Helical|||Signal peptidase I ^@ http://purl.uniprot.org/annotation/PRO_0000109511 http://togogenome.org/gene/83332:Rv2396 ^@ http://purl.uniprot.org/uniprot/Q79FE6 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent|||Signal Peptide ^@ PE|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_5004286540 http://togogenome.org/gene/83332:Rv1820 ^@ http://purl.uniprot.org/uniprot/P9WG39 ^@ Modification|||Molecule Processing|||Site ^@ Binding Site|||Chain|||Initiator Methionine|||Modified Residue ^@ Acetolactate synthase large subunit IlvG|||N-acetylserine|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000090805 http://togogenome.org/gene/83332:Rv0777 ^@ http://purl.uniprot.org/uniprot/I6XWA1 ^@ Region ^@ Domain Extent ^@ ADSL_C ^@ http://togogenome.org/gene/83332:Rv3158 ^@ http://purl.uniprot.org/uniprot/P9WIW9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||NADH-quinone oxidoreductase subunit N ^@ http://purl.uniprot.org/annotation/PRO_0000117693 http://togogenome.org/gene/83332:Rv1277 ^@ http://purl.uniprot.org/uniprot/Q50699 ^@ Region ^@ Domain Extent ^@ Metallophos ^@ http://togogenome.org/gene/83332:Rv1632c ^@ http://purl.uniprot.org/uniprot/O06149 ^@ Region ^@ Domain Extent ^@ DUF402 ^@ http://togogenome.org/gene/83332:Rv2816c ^@ http://purl.uniprot.org/uniprot/P9WPJ3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ CRISPR-associated endoribonuclease Cas2 ^@ http://purl.uniprot.org/annotation/PRO_0000418219 http://togogenome.org/gene/83332:Rv1453 ^@ http://purl.uniprot.org/uniprot/O06807 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||GGDEF_2|||HTH_30 ^@ http://togogenome.org/gene/83332:Rv1108c ^@ http://purl.uniprot.org/uniprot/P9WF31 ^@ Molecule Processing ^@ Chain ^@ Exodeoxyribonuclease 7 large subunit ^@ http://purl.uniprot.org/annotation/PRO_0000197860 http://togogenome.org/gene/83332:Rv3347c ^@ http://purl.uniprot.org/uniprot/Q6MWX9 ^@ Region ^@ Domain Extent ^@ PPE ^@ http://togogenome.org/gene/83332:Rv1934c ^@ http://purl.uniprot.org/uniprot/P95280 ^@ Molecule Processing ^@ Chain ^@ Putative acyl-CoA dehydrogenase FadE17 ^@ http://purl.uniprot.org/annotation/PRO_0000438538 http://togogenome.org/gene/83332:Rv3124 ^@ http://purl.uniprot.org/uniprot/O05797 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||DNA Binding|||Mutagenesis Site ^@ Completely disrupts protein function, as shown by the dramatic decrease of RNA levels for the moa1 locus.|||Has no deleterious effect on the transcription of the moa1 locus.|||OmpR/PhoB-type|||Shows reduced transcription of the moa1 locus.|||Shows significantly reduced transcription of the moa1 locus.|||Transcriptional regulatory protein MoaR1 ^@ http://purl.uniprot.org/annotation/PRO_0000415513 http://togogenome.org/gene/83332:Rv1962A ^@ http://purl.uniprot.org/uniprot/P9WF17 ^@ Molecule Processing ^@ Chain ^@ Antitoxin VapB35 ^@ http://purl.uniprot.org/annotation/PRO_0000408048 http://togogenome.org/gene/83332:Rv0002 ^@ http://purl.uniprot.org/uniprot/P9WNU1 ^@ Experimental Information|||Molecule Processing|||Secondary Structure ^@ Chain|||Helix|||Sequence Conflict|||Strand|||Turn ^@ Beta sliding clamp ^@ http://purl.uniprot.org/annotation/PRO_0000105451 http://togogenome.org/gene/83332:Rv1746 ^@ http://purl.uniprot.org/uniprot/P9WI75 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Transmembrane|||Turn ^@ Abolishes interaction with Rv1747. Impairs autokinase activity.|||Decreases interaction with Rv1747.|||Decreases interaction with Rv1747. Decreases autokinase activity.|||Helical|||Loss of kinase activity. Abolishes interaction with Rv1747.|||Phosphoserine; by autocatalysis|||Phosphothreonine; by autocatalysis|||Polar residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknF ^@ http://purl.uniprot.org/annotation/PRO_0000171213 http://togogenome.org/gene/83332:Rv2932 ^@ http://purl.uniprot.org/uniprot/P9WQE5 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Modified Residue ^@ Carrier|||For beta-ketoacyl synthase activity|||For malonyltransferase activity|||Ketosynthase family 3 (KS3)|||O-(pantetheine 4'-phosphoryl)serine|||Phenolphthiocerol/phthiocerol polyketide synthase subunit B ^@ http://purl.uniprot.org/annotation/PRO_0000180302 http://togogenome.org/gene/83332:Rv3467 ^@ http://purl.uniprot.org/uniprot/Q50655 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||HNHc ^@ http://togogenome.org/gene/83332:Rv0181c ^@ http://purl.uniprot.org/uniprot/P9WI85 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative quercetin 2,3-dioxygenase Rv0181c ^@ http://purl.uniprot.org/annotation/PRO_0000214065 http://togogenome.org/gene/83332:Rv3433c ^@ http://purl.uniprot.org/uniprot/P9WF11 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ Bifunctional NAD(P)H-hydrate repair enzyme Nnr|||YjeF C-terminal|||YjeF N-terminal ^@ http://purl.uniprot.org/annotation/PRO_0000119048 http://togogenome.org/gene/83332:Rv0669c ^@ http://purl.uniprot.org/uniprot/O06769 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Neutral ceramidase|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000420250 http://togogenome.org/gene/83332:Rv0141c ^@ http://purl.uniprot.org/uniprot/P96818 ^@ Region ^@ Domain Extent ^@ SnoaL-like ^@ http://togogenome.org/gene/83332:Rv3804c ^@ http://purl.uniprot.org/uniprot/P9WQP3 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Disulfide Bond|||Helix|||Mutagenesis Site|||Signal Peptide|||Strand|||Turn ^@ Abolishes diacylglycerol acyltransferase activity.|||Diacylglycerol acyltransferase/mycolyltransferase Ag85A|||Nucleophile|||Tat-type signal ^@ http://purl.uniprot.org/annotation/PRO_0000000214 http://togogenome.org/gene/83332:Rv2760c ^@ http://purl.uniprot.org/uniprot/P9WJ19 ^@ Molecule Processing ^@ Chain ^@ Putative antitoxin VapB42 ^@ http://purl.uniprot.org/annotation/PRO_0000408083 http://togogenome.org/gene/83332:Rv2429 ^@ http://purl.uniprot.org/uniprot/P9WQB5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Alkyl hydroperoxide reductase AhpD|||Cysteine sulfenic acid (-SOH) intermediate|||Interchain (with C-61 in AhpC); in linked form|||Loss of activity.|||Loss of activity. Loss of interchain disulfide bond with AhpC.|||Proton donor|||Reduced catalytic activity.|||Reduces protein stability. No effect on catalytic activity.|||Slightly reduced catalytic activity. ^@ http://purl.uniprot.org/annotation/PRO_0000064507 http://togogenome.org/gene/83332:Rv3624c ^@ http://purl.uniprot.org/uniprot/P9WHQ9 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Sequence Conflict|||Strand|||Turn ^@ Hypoxanthine-guanine phosphoribosyltransferase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000139609 http://togogenome.org/gene/83332:Rv3250c ^@ http://purl.uniprot.org/uniprot/I6YFL7 ^@ Region ^@ Domain Extent ^@ Rubredoxin-like ^@ http://togogenome.org/gene/83332:Rv0496 ^@ http://purl.uniprot.org/uniprot/P9WHV5 ^@ Molecule Processing ^@ Chain ^@ Exopolyphosphatase 1 ^@ http://purl.uniprot.org/annotation/PRO_0000194307 http://togogenome.org/gene/83332:Rv3437 ^@ http://purl.uniprot.org/uniprot/I6YG51 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DUF2510|||Helical ^@ http://togogenome.org/gene/83332:Rv2159c ^@ http://purl.uniprot.org/uniprot/O06218 ^@ Region ^@ Domain Extent ^@ CMD ^@ http://togogenome.org/gene/83332:Rv0789c ^@ http://purl.uniprot.org/uniprot/I6Y4U0 ^@ Region ^@ Compositionally Biased Region ^@ Basic and acidic residues ^@ http://togogenome.org/gene/83332:Rv3921c ^@ http://purl.uniprot.org/uniprot/P9WIT5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Transmembrane ^@ Helical|||Membrane protein insertase YidC|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000124730 http://togogenome.org/gene/83332:Rv1166 ^@ http://purl.uniprot.org/uniprot/P9WGU7 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Signal Peptide ^@ Polar residues|||Pro residues|||Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW ^@ http://purl.uniprot.org/annotation/PRO_0000393727 http://togogenome.org/gene/83332:Rv2336 ^@ http://purl.uniprot.org/uniprot/P95232 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv1986 ^@ http://purl.uniprot.org/uniprot/P9WK31 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Lysine exporter LysE ^@ http://purl.uniprot.org/annotation/PRO_0000103916 http://togogenome.org/gene/83332:Rv1130 ^@ http://purl.uniprot.org/uniprot/O06582 ^@ Molecule Processing ^@ Chain ^@ 2-methylcitrate dehydratase ^@ http://purl.uniprot.org/annotation/PRO_0000432935 http://togogenome.org/gene/83332:Rv0617 ^@ http://purl.uniprot.org/uniprot/P9WF79 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC29 ^@ http://purl.uniprot.org/annotation/PRO_0000407887 http://togogenome.org/gene/83332:Rv0088 ^@ http://purl.uniprot.org/uniprot/P9WM73 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0088 ^@ http://purl.uniprot.org/annotation/PRO_0000103662 http://togogenome.org/gene/83332:Rv2653c ^@ http://purl.uniprot.org/uniprot/P9WJ13 ^@ Molecule Processing ^@ Chain ^@ Toxin Rv2653c ^@ http://purl.uniprot.org/annotation/PRO_0000406887 http://togogenome.org/gene/83332:Rv2130c ^@ http://purl.uniprot.org/uniprot/P9WJM9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Motif ^@ 'ERGGDP' region|||'HIGH' region|||'KMSKS' region|||L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase ^@ http://purl.uniprot.org/annotation/PRO_0000159442 http://togogenome.org/gene/83332:Rv0758 ^@ http://purl.uniprot.org/uniprot/P71815 ^@ Region ^@ Domain Extent|||Transmembrane ^@ HAMP|||Helical|||Histidine kinase ^@ http://togogenome.org/gene/83332:Rv0527 ^@ http://purl.uniprot.org/uniprot/L7N671 ^@ Region ^@ Domain Extent|||Transmembrane ^@ DsbD|||Helical ^@ http://togogenome.org/gene/83332:Rv2459 ^@ http://purl.uniprot.org/uniprot/P9WJW9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Drug efflux pump JefA|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000390685 http://togogenome.org/gene/83332:Rv2942 ^@ http://purl.uniprot.org/uniprot/P9WJU7 ^@ Experimental Information|||Molecule Processing|||Region ^@ Chain|||Mutagenesis Site|||Transmembrane ^@ Helical|||Leads to decreased interaction with PpsE, but does not decrease MmpL7 activity in vivo.|||Phthiocerol dimycocerosate exporter MmpL7 ^@ http://purl.uniprot.org/annotation/PRO_0000103570 http://togogenome.org/gene/83332:Rv0191 ^@ http://purl.uniprot.org/uniprot/P9WJX7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Chloramphenicol efflux pump Rv0191|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000390681 http://togogenome.org/gene/83332:Rv1421 ^@ http://purl.uniprot.org/uniprot/P9WFQ3 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Nucleotide-binding protein Rv1421 ^@ http://purl.uniprot.org/annotation/PRO_0000107732 http://togogenome.org/gene/83332:Rv3214 ^@ http://purl.uniprot.org/uniprot/Q6MWZ7 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Acid phosphatase|||Proton donor/acceptor|||Tele-phosphohistidine intermediate ^@ http://purl.uniprot.org/annotation/PRO_0000437244 http://togogenome.org/gene/83332:Rv2599 ^@ http://purl.uniprot.org/uniprot/P9WL69 ^@ Molecule Processing|||Region ^@ Chain|||Signal Peptide|||Transmembrane ^@ Helical|||Uncharacterized protein Rv2599 ^@ http://purl.uniprot.org/annotation/PRO_0000014143 http://togogenome.org/gene/83332:Rv1019 ^@ http://purl.uniprot.org/uniprot/P96381 ^@ Region ^@ DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH tetR-type ^@ http://togogenome.org/gene/83332:Rv2243 ^@ http://purl.uniprot.org/uniprot/P9WNG5 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Crosslink|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)|||Malonyl CoA-acyl carrier protein transacylase|||Nearly abolishes pupylation and dramatically stabilizes this proteasome substrate in wild-type mycobacteria. ^@ http://purl.uniprot.org/annotation/PRO_0000194218 http://togogenome.org/gene/83332:Rv1563c ^@ http://purl.uniprot.org/uniprot/P9WQ21 ^@ Molecule Processing ^@ Chain ^@ Putative maltooligosyl trehalose synthase ^@ http://purl.uniprot.org/annotation/PRO_0000054342 http://togogenome.org/gene/83332:Rv3792 ^@ http://purl.uniprot.org/uniprot/P9WN03 ^@ Molecule Processing|||Region ^@ Chain|||Topological Domain|||Transmembrane ^@ Extracellular|||Galactan 5-O-arabinofuranosyltransferase|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000250356 http://togogenome.org/gene/83332:Rv2914c ^@ http://purl.uniprot.org/uniprot/P9WI69 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Strand|||Topological Domain|||Transmembrane|||Turn ^@ Cytoplasmic|||Extracellular|||Helical|||Polar residues|||Protein kinase|||Proton acceptor|||Serine/threonine-protein kinase PknI ^@ http://purl.uniprot.org/annotation/PRO_0000171220 http://togogenome.org/gene/83332:Rv1674c ^@ http://purl.uniprot.org/uniprot/O53921 ^@ Region ^@ Domain Extent ^@ HTH arsR-type|||Rhodanese ^@ http://togogenome.org/gene/83332:Rv1830 ^@ http://purl.uniprot.org/uniprot/P9WME5 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||HTH merR-type|||Polar residues|||Uncharacterized HTH-type transcriptional regulator Rv1830 ^@ http://purl.uniprot.org/annotation/PRO_0000098170 http://togogenome.org/gene/83332:Rv0455c ^@ http://purl.uniprot.org/uniprot/O53740 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5030174834 http://togogenome.org/gene/83332:Rv1319c ^@ http://purl.uniprot.org/uniprot/P9WQ31 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ Guanylate cyclase|||HAMP|||Helical|||Uncharacterized protein Rv1319c ^@ http://purl.uniprot.org/annotation/PRO_0000195754 http://togogenome.org/gene/83332:Rv3587c ^@ http://purl.uniprot.org/uniprot/O53572 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv0099 ^@ http://purl.uniprot.org/uniprot/P9WQ55 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Medium/long-chain-fatty-acid--[acyl-carrier-protein] ligase FadD10 ^@ http://purl.uniprot.org/annotation/PRO_0000420403 http://togogenome.org/gene/83332:Rv1287 ^@ http://purl.uniprot.org/uniprot/P9WME3 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ HTH rrf2-type|||Putative HTH-type transcriptional regulator Rv1287 ^@ http://purl.uniprot.org/annotation/PRO_0000036205 http://togogenome.org/gene/83332:Rv1642 ^@ http://purl.uniprot.org/uniprot/P9WH91 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L35 ^@ http://purl.uniprot.org/annotation/PRO_0000177387 http://togogenome.org/gene/83332:Rv0277c ^@ http://purl.uniprot.org/uniprot/P9WF85 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent ^@ PINc|||Ribonuclease VapC25 ^@ http://purl.uniprot.org/annotation/PRO_0000407884 http://togogenome.org/gene/83332:Rv0634B ^@ http://purl.uniprot.org/uniprot/P9WH95 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L33 2 ^@ http://purl.uniprot.org/annotation/PRO_0000170195 http://togogenome.org/gene/83332:Rv1945 ^@ http://purl.uniprot.org/uniprot/P9WLQ5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ HNH|||Uncharacterized protein Rv1945 ^@ http://purl.uniprot.org/annotation/PRO_0000103914 http://togogenome.org/gene/83332:Rv1761c ^@ http://purl.uniprot.org/uniprot/O06796 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2611c ^@ http://purl.uniprot.org/uniprot/P9WMB5 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Phosphatidylinositol mannoside acyltransferase|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000393105 http://togogenome.org/gene/83332:Rv3483c ^@ http://purl.uniprot.org/uniprot/I6X7F2 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3443c ^@ http://purl.uniprot.org/uniprot/P9WHE1 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L13 ^@ http://purl.uniprot.org/annotation/PRO_0000133744 http://togogenome.org/gene/83332:Rv0680c ^@ http://purl.uniprot.org/uniprot/I6Y4F1 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010186597 http://togogenome.org/gene/83332:Rv3816c ^@ http://purl.uniprot.org/uniprot/O07807 ^@ Region ^@ Domain Extent ^@ PlsC ^@ http://togogenome.org/gene/83332:Rv2441c ^@ http://purl.uniprot.org/uniprot/P9WHB3 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L27 ^@ http://purl.uniprot.org/annotation/PRO_0000181130 http://togogenome.org/gene/83332:Rv3634c ^@ http://purl.uniprot.org/uniprot/P9WN67 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Proton acceptor|||UDP-glucose 4-epimerase ^@ http://purl.uniprot.org/annotation/PRO_0000420762 http://togogenome.org/gene/83332:Rv3260c ^@ http://purl.uniprot.org/uniprot/O53353 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Mass|||Modified Residue|||Mutagenesis Site ^@ 4Fe-4S Wbl-type|||Considerable loss of chaperone activity.|||Fully oxidized recombinant protein tagged at both termini.|||Fully reduced recombinant protein tagged at both termini.|||Phosphoserine|||Retains chaperone activity; when associated with A-27, A-50 and A-53.|||Retains chaperone activity; when associated with A-27, A-50 and A-59.|||Retains chaperone activity; when associated with A-27, A-53 and A-59.|||Retains chaperone activity; when associated with A-50, A-53 and A-59.|||Transcriptional regulator WhiB2 ^@ http://purl.uniprot.org/annotation/PRO_0000420380 http://togogenome.org/gene/83332:Rv0507 ^@ http://purl.uniprot.org/uniprot/P9WJV7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Probable transport protein MmpL2 ^@ http://purl.uniprot.org/annotation/PRO_0000103563 http://togogenome.org/gene/83332:Rv0255c ^@ http://purl.uniprot.org/uniprot/P9WP95 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Chain|||Domain Extent ^@ Cobyric acid synthase|||GATase cobBQ-type|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000141312 http://togogenome.org/gene/83332:Rv1340 ^@ http://purl.uniprot.org/uniprot/P9WGZ7 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand ^@ Ribonuclease PH ^@ http://purl.uniprot.org/annotation/PRO_0000139912 http://togogenome.org/gene/83332:Rv0314c ^@ http://purl.uniprot.org/uniprot/O07241 ^@ Region ^@ Compositionally Biased Region|||Transmembrane ^@ Helical|||Pro residues ^@ http://togogenome.org/gene/83332:Rv0802c ^@ http://purl.uniprot.org/uniprot/P9WQG7 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Strand|||Turn ^@ N-acetyltransferase|||Putative succinyl-CoA transferase Rv0802c ^@ http://purl.uniprot.org/annotation/PRO_0000414586 http://togogenome.org/gene/83332:Rv1179c ^@ http://purl.uniprot.org/uniprot/O50435 ^@ Region ^@ Domain Extent ^@ Helicase ATP-binding ^@ http://togogenome.org/gene/83332:Rv2347c ^@ http://purl.uniprot.org/uniprot/P9WNI5 ^@ Molecule Processing|||Secondary Structure ^@ Chain|||Helix ^@ ESAT-6-like protein EsxP ^@ http://purl.uniprot.org/annotation/PRO_0000167815 http://togogenome.org/gene/83332:Rv3753c ^@ http://purl.uniprot.org/uniprot/O69720 ^@ Molecule Processing ^@ Chain|||Initiator Methionine ^@ Protein Rv3753c|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000456391 http://togogenome.org/gene/83332:Rv2836c ^@ http://purl.uniprot.org/uniprot/P71616 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0629c ^@ http://purl.uniprot.org/uniprot/P9WHJ1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ RecBCD enzyme subunit RecD ^@ http://purl.uniprot.org/annotation/PRO_0000390680 http://togogenome.org/gene/83332:Rv3515c ^@ http://purl.uniprot.org/uniprot/P9WQ51 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Basic and acidic residues|||Medium/long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000406790 http://togogenome.org/gene/83332:Rv1463 ^@ http://purl.uniprot.org/uniprot/O53154 ^@ Region ^@ Domain Extent ^@ ABC transporter ^@ http://togogenome.org/gene/83332:Rv0769 ^@ http://purl.uniprot.org/uniprot/P9WGQ9 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Proton acceptor|||Uncharacterized oxidoreductase Rv0769 ^@ http://purl.uniprot.org/annotation/PRO_0000415505 http://togogenome.org/gene/83332:Rv3504 ^@ http://purl.uniprot.org/uniprot/I6YCA3 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ Acyl-CoA dehydrogenase FadE26|||Loss of dehydrogenase activity.|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000438520 http://togogenome.org/gene/83332:Rv2162c ^@ http://purl.uniprot.org/uniprot/L7N6A1 ^@ Region ^@ Domain Extent ^@ PE ^@ http://togogenome.org/gene/83332:Rv1291c ^@ http://purl.uniprot.org/uniprot/P9WM33 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1291c ^@ http://purl.uniprot.org/annotation/PRO_0000103791 http://togogenome.org/gene/83332:Rv2952 ^@ http://purl.uniprot.org/uniprot/P9WIN3 ^@ Molecule Processing ^@ Chain ^@ Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000305165 http://togogenome.org/gene/83332:Rv3318 ^@ http://purl.uniprot.org/uniprot/O53370 ^@ Modification|||Region|||Site ^@ Active Site|||Domain Extent|||Modified Residue ^@ FAD_binding_2|||Proton acceptor|||Succ_DH_flav_C|||Tele-8alpha-FAD histidine ^@ http://togogenome.org/gene/83332:Rv2291 ^@ http://purl.uniprot.org/uniprot/P9WHF5 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent ^@ Cysteine persulfide intermediate|||Putative thiosulfate sulfurtransferase SseB|||Rhodanese 1|||Rhodanese 2 ^@ http://purl.uniprot.org/annotation/PRO_0000139419 http://togogenome.org/gene/83332:Rv3306c ^@ http://purl.uniprot.org/uniprot/L7N690 ^@ Region ^@ Domain Extent ^@ M20_dimer ^@ http://togogenome.org/gene/83332:Rv3132c ^@ http://purl.uniprot.org/uniprot/P9WGK3 ^@ Experimental Information|||Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Domain Extent|||Helix|||Initiator Methionine|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Can form a disulfide bond; when associated with C-440. Decreased autophosphorylation; when associated with C-524. Loss of autophosphorylation; when associated with C-440 or C-440 and C-524.|||Can form a disulfide bond; when associated with C-537. Loss of autophosphorylation; when associated with C-524 or C-524 and C-537.|||Decreased autophosphorylation when CO- or NO-bound, none in the deoxy or O(2)-bound state, protein more easily oxidized to Fe(3+) state.|||GAF 1|||GAF 2|||Histidine kinase|||Isolated kinase core no longer forms dimers, autophosphorylation unaffected. Decreased autophosphorylation; when associated with C-537. Loss of autophosphorylation; when associated with C-440 or C-440 and C-537.|||N-acetylthreonine|||No autophosphorylation activity no matter the bound gaseous ligand, protein more easily oxidized to Fe(3+) state.|||No autophosphorylation activity no matter the bound gaseous ligand.|||No autophosphorylation when Fe(2+) protein is bound to CO or NO; no change in autophosphorylation of deoxy-protein. No change in auto-oxidation, slightly higher affinity for O(2) and CO.|||No autophosphorylation, no transfer to DevR (DosR).|||No autophosphorylation.|||No autophosphorylation. Isolated kinase core binds ATP.|||No change in autophosphorylation when NO-bound, decreased autophosphorylation in deoxy or CO-bound state, slightly increased activity in O(2)-bound state.|||No change in autophosphorylation when NO-bound, loss of autophosphorylation in deoxy or CO-bound state.|||No change in autophosphorylation when deoxy or NO-bound, decreased autophosphorylation when CO-bound, increased activity in O(2)-bound state.|||No change in heme binding.|||No change in phosphorylation.|||Oxygen sensor histidine kinase response regulator DevS/DosS|||Phosphohistidine; by autocatalysis|||Removed|||Weaker than wild-type heme binding.|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000392623 http://togogenome.org/gene/83332:Rv2784c ^@ http://purl.uniprot.org/uniprot/I6XFA6 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010168519 http://togogenome.org/gene/83332:Rv2253 ^@ http://purl.uniprot.org/uniprot/O53527 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ Secreted protein ^@ http://purl.uniprot.org/annotation/PRO_5010277635 http://togogenome.org/gene/83332:Rv1706c ^@ http://purl.uniprot.org/uniprot/P9WI17 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE23 ^@ http://purl.uniprot.org/annotation/PRO_0000378479 http://togogenome.org/gene/83332:Rv2924c ^@ http://purl.uniprot.org/uniprot/P9WNC3 ^@ Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Initiator Methionine|||Zinc Finger ^@ FPG-type|||Formamidopyrimidine-DNA glycosylase 1|||Proton donor|||Proton donor; for beta-elimination activity|||Proton donor; for delta-elimination activity|||Removed|||Schiff-base intermediate with DNA ^@ http://purl.uniprot.org/annotation/PRO_0000170840 http://togogenome.org/gene/83332:Rv3447c ^@ http://purl.uniprot.org/uniprot/P9WNA7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Domain Extent|||Transmembrane ^@ ESX-4 secretion system protein EccC4|||FtsK 1|||FtsK 2|||FtsK 3|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393431 http://togogenome.org/gene/83332:Rv0651 ^@ http://purl.uniprot.org/uniprot/P9WHE7 ^@ Molecule Processing ^@ Chain ^@ 50S ribosomal protein L10 ^@ http://purl.uniprot.org/annotation/PRO_0000154674 http://togogenome.org/gene/83332:Rv2362c ^@ http://purl.uniprot.org/uniprot/P9WHI5 ^@ Molecule Processing ^@ Chain ^@ DNA repair protein RecO ^@ http://purl.uniprot.org/annotation/PRO_0000204972 http://togogenome.org/gene/83332:Rv0145 ^@ http://purl.uniprot.org/uniprot/P9WFJ1 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0145 ^@ http://purl.uniprot.org/annotation/PRO_0000361235 http://togogenome.org/gene/83332:Rv1841c ^@ http://purl.uniprot.org/uniprot/P9WLQ7 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent|||Transmembrane ^@ CBS 1|||CBS 2|||CNNM transmembrane|||Helical|||Uncharacterized protein Rv1841c ^@ http://purl.uniprot.org/annotation/PRO_0000103913 http://togogenome.org/gene/83332:Rv0465c ^@ http://purl.uniprot.org/uniprot/P9WMI1 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Domain Extent ^@ H-T-H motif|||HTH cro/C1-type|||HTH-type transcriptional regulator RamB ^@ http://purl.uniprot.org/annotation/PRO_0000382634 http://togogenome.org/gene/83332:Rv1330c ^@ http://purl.uniprot.org/uniprot/P9WJI9 ^@ Modification|||Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Modified Residue ^@ Basic and acidic residues|||Nicotinate phosphoribosyltransferase pncB1|||Phosphohistidine ^@ http://purl.uniprot.org/annotation/PRO_0000103804 http://togogenome.org/gene/83332:Rv3601c ^@ http://purl.uniprot.org/uniprot/P9WIL3 ^@ Experimental Information|||Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Modified Residue|||Mutagenesis Site|||Strand|||Turn ^@ Aspartate 1-decarboxylase alpha chain|||Aspartate 1-decarboxylase beta chain|||In S11; may confer PZA resistance; when associated with R-21.|||In S11; may confer PZA resistance; when associated with V-49.|||In S13; may confer PZA resistance.|||In S6; may confer PZA resistance.|||In S9, S10; may confer PZA resistance.|||Proton donor|||Pyruvic acid (Ser)|||Schiff-base intermediate with substrate; via pyruvic acid ^@ http://purl.uniprot.org/annotation/PRO_0000023121|||http://purl.uniprot.org/annotation/PRO_0000023122 http://togogenome.org/gene/83332:Rv0111 ^@ http://purl.uniprot.org/uniprot/O53633 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Acyl_transf_3|||Helical|||SGNH ^@ http://togogenome.org/gene/83332:Rv1654 ^@ http://purl.uniprot.org/uniprot/P9WQ01 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand|||Turn ^@ Acetylglutamate kinase ^@ http://purl.uniprot.org/annotation/PRO_0000112637 http://togogenome.org/gene/83332:Rv0292 ^@ http://purl.uniprot.org/uniprot/P9WJE5 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ ESX-3 secretion system protein EccE3|||Helical ^@ http://purl.uniprot.org/annotation/PRO_0000393871 http://togogenome.org/gene/83332:Rv1138c ^@ http://purl.uniprot.org/uniprot/O06538 ^@ Region ^@ Domain Extent ^@ FAD_binding_3 ^@ http://togogenome.org/gene/83332:Rv0747 ^@ http://purl.uniprot.org/uniprot/P9WIG1 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||Uncharacterized PE-PGRS family protein PE_PGRS10 ^@ http://purl.uniprot.org/annotation/PRO_0000023576 http://togogenome.org/gene/83332:Rv3855 ^@ http://purl.uniprot.org/uniprot/P9WMC1 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Helix|||Turn ^@ H-T-H motif|||HTH tetR-type|||HTH-type transcriptional regulator EthR ^@ http://purl.uniprot.org/annotation/PRO_0000398578 http://togogenome.org/gene/83332:Rv1956 ^@ http://purl.uniprot.org/uniprot/P9WJA7 ^@ Molecule Processing|||Region|||Secondary Structure ^@ Chain|||DNA Binding|||Domain Extent|||Strand ^@ Antitoxin HigA1|||H-T-H motif|||HTH cro/C1-type ^@ http://purl.uniprot.org/annotation/PRO_0000407371 http://togogenome.org/gene/83332:Rv2484c ^@ http://purl.uniprot.org/uniprot/P9WKB3 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Proton acceptor|||Putative diacyglycerol O-acyltransferase Rv2484c ^@ http://purl.uniprot.org/annotation/PRO_0000222912 http://togogenome.org/gene/83332:Rv2301 ^@ http://purl.uniprot.org/uniprot/P9WP41 ^@ Modification|||Molecule Processing|||Site ^@ Active Site|||Chain|||Disulfide Bond|||Signal Peptide ^@ Nucleophile|||Probable carboxylesterase Culp2|||Proton donor/acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000006449 http://togogenome.org/gene/83332:Rv1774 ^@ http://purl.uniprot.org/uniprot/O33177 ^@ Region ^@ Domain Extent ^@ FAD-binding PCMH-type ^@ http://togogenome.org/gene/83332:Rv3493c ^@ http://purl.uniprot.org/uniprot/I6X7G4 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2623 ^@ http://purl.uniprot.org/uniprot/P9WFD7 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand ^@ Reduces ATP-binding; M.tuberculosis overexpressing this protein grows normally.|||Universal stress protein Rv2623 ^@ http://purl.uniprot.org/annotation/PRO_0000392628 http://togogenome.org/gene/83332:Rv0413 ^@ http://purl.uniprot.org/uniprot/P9WIX9 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Motif ^@ Basic and acidic residues|||Nudix box|||Nudix hydrolase|||Putative 8-oxo-dGTP diphosphatase 3 ^@ http://purl.uniprot.org/annotation/PRO_0000391777 http://togogenome.org/gene/83332:Rv2451 ^@ http://purl.uniprot.org/uniprot/O53178 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@ http://togogenome.org/gene/83332:Rv1790 ^@ http://purl.uniprot.org/uniprot/Q79FK5 ^@ Region ^@ Domain Extent ^@ PPE|||PPE-SVP ^@ http://togogenome.org/gene/83332:Rv0518 ^@ http://purl.uniprot.org/uniprot/O33363 ^@ Experimental Information|||Molecule Processing|||Site ^@ Active Site|||Chain|||Mutagenesis Site|||Signal Peptide ^@ GDSL lipase Rv0518|||Loss of activity.|||Nucleophile|||Proton acceptor|||Proton donor|||Retains 15-20% of activity.|||Retains 50-55% of activity. ^@ http://purl.uniprot.org/annotation/PRO_0000448306 http://togogenome.org/gene/83332:Rv3277 ^@ http://purl.uniprot.org/uniprot/P96882 ^@ Region ^@ Domain Extent|||Transmembrane ^@ GtrA|||Helical ^@ http://togogenome.org/gene/83332:Rv0296c ^@ http://purl.uniprot.org/uniprot/Q6MX51 ^@ Modification|||Region ^@ Domain Extent|||Modified Residue ^@ 3-oxoalanine (Cys)|||Sulfatase ^@ http://togogenome.org/gene/83332:Rv1351 ^@ http://purl.uniprot.org/uniprot/P9WM17 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1351 ^@ http://purl.uniprot.org/annotation/PRO_0000103821 http://togogenome.org/gene/83332:Rv3093c ^@ http://purl.uniprot.org/uniprot/O05772 ^@ Region ^@ Domain Extent ^@ Bac_luciferase ^@ http://togogenome.org/gene/83332:Rv0813c ^@ http://purl.uniprot.org/uniprot/P9WFG9 ^@ Modification|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Motif|||Strand|||Turn ^@ GXWXGXG|||N-acetylserine|||Peroxynitrite isomerase 2|||Removed|||axial binding residue ^@ http://purl.uniprot.org/annotation/PRO_0000356933 http://togogenome.org/gene/83332:Rv1189 ^@ http://purl.uniprot.org/uniprot/P9WGH3 ^@ Molecule Processing|||Region ^@ Chain|||DNA Binding|||Motif ^@ H-T-H motif|||Polymerase core binding|||Probable ECF RNA polymerase sigma factor SigI ^@ http://purl.uniprot.org/annotation/PRO_0000423647 http://togogenome.org/gene/83332:Rv2569c ^@ http://purl.uniprot.org/uniprot/P9WL93 ^@ Modification|||Molecule Processing ^@ Chain|||Initiator Methionine|||Modified Residue ^@ N-acetylserine|||Removed|||Uncharacterized protein Rv2569c ^@ http://purl.uniprot.org/annotation/PRO_0000104047 http://togogenome.org/gene/83332:Rv0640 ^@ http://purl.uniprot.org/uniprot/P9WHE5 ^@ Modification|||Molecule Processing ^@ Chain|||Crosslink ^@ 50S ribosomal protein L11|||Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) ^@ http://purl.uniprot.org/annotation/PRO_0000104325 http://togogenome.org/gene/83332:Rv1475c ^@ http://purl.uniprot.org/uniprot/O53166 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Aconitate hydratase A ^@ http://purl.uniprot.org/annotation/PRO_0000432979 http://togogenome.org/gene/83332:Rv3520c ^@ http://purl.uniprot.org/uniprot/O53565 ^@ Molecule Processing ^@ Chain ^@ Putative coenzyme F420-dependent oxidoreductase Rv3520c ^@ http://purl.uniprot.org/annotation/PRO_0000415512 http://togogenome.org/gene/83332:Rv1301 ^@ http://purl.uniprot.org/uniprot/P9WGC9 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ Putative threonylcarbamoyl-AMP synthase|||YrdC-like ^@ http://purl.uniprot.org/annotation/PRO_0000202025 http://togogenome.org/gene/83332:Rv2146c ^@ http://purl.uniprot.org/uniprot/O06230 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv2962c ^@ http://purl.uniprot.org/uniprot/P9WN09 ^@ Molecule Processing ^@ Chain ^@ PGL/p-HBAD biosynthesis rhamnosyltransferase ^@ http://purl.uniprot.org/annotation/PRO_0000313792 http://togogenome.org/gene/83332:Rv0211 ^@ http://purl.uniprot.org/uniprot/P9WIH3 ^@ Modification|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Initiator Methionine|||Modified Residue|||Strand|||Turn ^@ N-acetylthreonine|||Phosphoenolpyruvate carboxykinase [GTP]|||Removed ^@ http://purl.uniprot.org/annotation/PRO_0000103611 http://togogenome.org/gene/83332:Rv3332 ^@ http://purl.uniprot.org/uniprot/O53382 ^@ Region|||Site ^@ Active Site|||Binding Site|||Domain Extent ^@ Amidohydro-rel|||Proton donor/acceptor ^@ http://togogenome.org/gene/83332:Rv1971 ^@ http://purl.uniprot.org/uniprot/O53972 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||MlaD ^@ http://togogenome.org/gene/83332:Rv3145 ^@ http://purl.uniprot.org/uniprot/P9WIW7 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||NADH-quinone oxidoreductase subunit A ^@ http://purl.uniprot.org/annotation/PRO_0000117870 http://togogenome.org/gene/83332:Rv2794c ^@ http://purl.uniprot.org/uniprot/O33336 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 100-fold decrease in phosphopantetheinylation activity.|||20-fold decrease in phosphopantetheinylation activity.|||4'-phosphopantetheinyl transferase PptT|||500-fold decrease in phosphopantetheinylation activity.|||Abolishes phosphopantetheinylation activity.|||Confers high-level resistance to compound 8918. ^@ http://purl.uniprot.org/annotation/PRO_0000451441 http://togogenome.org/gene/83332:Rv3646c ^@ http://purl.uniprot.org/uniprot/P9WG49 ^@ Experimental Information|||Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Compositionally Biased Region|||Domain Extent|||Helix|||Sequence Conflict|||Strand|||Turn ^@ Basic residues|||DNA topoisomerase 1|||O-(5'-phospho-DNA)-tyrosine intermediate|||Toprim ^@ http://purl.uniprot.org/annotation/PRO_0000145159 http://togogenome.org/gene/83332:Rv0874c ^@ http://purl.uniprot.org/uniprot/P9WKR9 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv0874c ^@ http://purl.uniprot.org/annotation/PRO_0000103717 http://togogenome.org/gene/83332:Rv0336 ^@ http://purl.uniprot.org/uniprot/O33266 ^@ Region ^@ Compositionally Biased Region|||Domain Extent ^@ HNHc|||Polar residues ^@ http://togogenome.org/gene/83332:Rv3459c ^@ http://purl.uniprot.org/uniprot/P9WH65 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region ^@ 30S ribosomal protein S11|||Basic residues ^@ http://purl.uniprot.org/annotation/PRO_0000123185 http://togogenome.org/gene/83332:Rv0157 ^@ http://purl.uniprot.org/uniprot/P96834 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||PNTB ^@ http://togogenome.org/gene/83332:Rv0478 ^@ http://purl.uniprot.org/uniprot/P9WP03 ^@ Molecule Processing|||Site ^@ Active Site|||Chain ^@ Deoxyribose-phosphate aldolase|||Proton donor/acceptor|||Schiff-base intermediate with acetaldehyde ^@ http://purl.uniprot.org/annotation/PRO_0000057248 http://togogenome.org/gene/83332:Rv3614c ^@ http://purl.uniprot.org/uniprot/P9WJD5 ^@ Experimental Information|||Molecule Processing ^@ Chain|||Mutagenesis Site ^@ Absence of EspD secretion.|||Absence of EspD secretion. Decreases EspA levels.|||Absence of EsxA secretion. Decreases EspD stability.|||Decreased EspD secretion and small reduction in cellular EspA levels.|||ESX-1 secretion-associated protein EspD ^@ http://purl.uniprot.org/annotation/PRO_0000393904 http://togogenome.org/gene/83332:Rv0995 ^@ http://purl.uniprot.org/uniprot/O05578 ^@ Region ^@ Domain Extent ^@ N-acetyltransferase ^@ http://togogenome.org/gene/83332:Rv0306 ^@ http://purl.uniprot.org/uniprot/O07233 ^@ Region ^@ Domain Extent ^@ Nitroreductase ^@ http://togogenome.org/gene/83332:Rv3017c ^@ http://purl.uniprot.org/uniprot/P9WNJ1 ^@ Molecule Processing ^@ Chain ^@ ESAT-6-like protein EsxQ ^@ http://purl.uniprot.org/annotation/PRO_0000167810 http://togogenome.org/gene/83332:Rv0817c ^@ http://purl.uniprot.org/uniprot/I6WZH9 ^@ Molecule Processing ^@ Chain|||Signal Peptide ^@ ^@ http://purl.uniprot.org/annotation/PRO_5010284879 http://togogenome.org/gene/83332:Rv2001 ^@ http://purl.uniprot.org/uniprot/P9WLN5 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2001 ^@ http://purl.uniprot.org/annotation/PRO_0000103929 http://togogenome.org/gene/83332:Rv1148c ^@ http://purl.uniprot.org/uniprot/P9WM55 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ HNH|||Uncharacterized protein Rv1148c ^@ http://purl.uniprot.org/annotation/PRO_0000103770 http://togogenome.org/gene/83332:Rv0779c ^@ http://purl.uniprot.org/uniprot/P71833 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv1967 ^@ http://purl.uniprot.org/uniprot/O53968 ^@ Region ^@ Domain Extent|||Transmembrane ^@ Helical|||Mce4_CUP1|||MlaD ^@ http://togogenome.org/gene/83332:Rv2496c ^@ http://purl.uniprot.org/uniprot/P9WIS1 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ 3-methyl-2-oxobutanoate dehydrogenase subunit beta|||Proton acceptor ^@ http://purl.uniprot.org/annotation/PRO_0000420519 http://togogenome.org/gene/83332:Rv0963c ^@ http://purl.uniprot.org/uniprot/P9WKM7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv0963c ^@ http://purl.uniprot.org/annotation/PRO_0000103759 http://togogenome.org/gene/83332:Rv2313c ^@ http://purl.uniprot.org/uniprot/P9WLB7 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2313c ^@ http://purl.uniprot.org/annotation/PRO_0000104024 http://togogenome.org/gene/83332:Rv2633c ^@ http://purl.uniprot.org/uniprot/P9WL59 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2633c ^@ http://purl.uniprot.org/annotation/PRO_0000104074 http://togogenome.org/gene/83332:Rv0423c ^@ http://purl.uniprot.org/uniprot/P9WG79 ^@ Molecule Processing|||Site ^@ Binding Site|||Chain ^@ Phosphomethylpyrimidine synthase ^@ http://purl.uniprot.org/annotation/PRO_0000152815 http://togogenome.org/gene/83332:Rv2462c ^@ http://purl.uniprot.org/uniprot/P9WG55 ^@ Molecule Processing|||Region ^@ Chain|||Compositionally Biased Region|||Domain Extent ^@ Basic and acidic residues|||PPIase FKBP-type|||Trigger factor ^@ http://purl.uniprot.org/annotation/PRO_0000179391 http://togogenome.org/gene/83332:Rv1818c ^@ http://purl.uniprot.org/uniprot/P9WIF5 ^@ Molecule Processing|||Region ^@ Chain|||Domain Extent ^@ PE|||PE-PGRS family protein PE_PGRS33 ^@ http://purl.uniprot.org/annotation/PRO_0000216164 http://togogenome.org/gene/83332:Rv3343c ^@ http://purl.uniprot.org/uniprot/Q6MWY2 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized PPE family protein PPE54 ^@ http://purl.uniprot.org/annotation/PRO_0000378486 http://togogenome.org/gene/83332:Rv3287c ^@ http://purl.uniprot.org/uniprot/P9WGX7 ^@ Molecule Processing|||Region|||Site ^@ Binding Site|||Chain|||Compositionally Biased Region ^@ Anti-sigma-F factor RsbW|||Polar residues ^@ http://purl.uniprot.org/annotation/PRO_0000422955 http://togogenome.org/gene/83332:Rv0379 ^@ http://purl.uniprot.org/uniprot/Q6MX43 ^@ Molecule Processing|||Secondary Structure|||Site ^@ Binding Site|||Chain|||Helix|||Strand ^@ Calcium dodecin ^@ http://purl.uniprot.org/annotation/PRO_0000429121 http://togogenome.org/gene/83332:Rv2934 ^@ http://purl.uniprot.org/uniprot/P9WQE3 ^@ Modification|||Molecule Processing|||Region|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Modified Residue ^@ Carrier|||For beta-ketoacyl synthase activity|||For malonyltransferase activity|||Ketosynthase family 3 (KS3)|||O-(pantetheine 4'-phosphoryl)serine|||Phenolphthiocerol/phthiocerol polyketide synthase subunit D ^@ http://purl.uniprot.org/annotation/PRO_0000406950 http://togogenome.org/gene/83332:Rv0183 ^@ http://purl.uniprot.org/uniprot/O07427 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Chain|||Helix|||Mass|||Mutagenesis Site|||Strand|||Turn ^@ Charge relay system|||Loss of lipase activity.|||Monoacylglycerol lipase|||Nucleophile ^@ http://purl.uniprot.org/annotation/PRO_0000438237 http://togogenome.org/gene/83332:Rv1362c ^@ http://purl.uniprot.org/uniprot/P9WM01 ^@ Molecule Processing|||Region ^@ Chain|||Transmembrane ^@ Helical|||Uncharacterized protein Rv1362c ^@ http://purl.uniprot.org/annotation/PRO_0000103831 http://togogenome.org/gene/83332:Rv3104c ^@ http://purl.uniprot.org/uniprot/O05781 ^@ Region ^@ Transmembrane ^@ Helical ^@ http://togogenome.org/gene/83332:Rv0823c ^@ http://purl.uniprot.org/uniprot/P9WNS7 ^@ Molecule Processing|||Site ^@ Active Site|||Binding Site|||Chain ^@ Probable tRNA-dihydrouridine synthase|||Proton donor ^@ http://purl.uniprot.org/annotation/PRO_0000162137 http://togogenome.org/gene/83332:Rv2580c ^@ http://purl.uniprot.org/uniprot/P9WFV5 ^@ Molecule Processing ^@ Chain ^@ Histidine--tRNA ligase ^@ http://purl.uniprot.org/annotation/PRO_0000136196 http://togogenome.org/gene/83332:Rv1201c ^@ http://purl.uniprot.org/uniprot/P9WP21 ^@ Experimental Information|||Molecule Processing|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Helix|||Mutagenesis Site|||Strand|||Turn ^@ 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase|||Acyl-anhydride intermediate|||Loss of activity. ^@ http://purl.uniprot.org/annotation/PRO_0000412254 http://togogenome.org/gene/83332:Rv2012 ^@ http://purl.uniprot.org/uniprot/P9WLM3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv2012 ^@ http://purl.uniprot.org/annotation/PRO_0000103941 http://togogenome.org/gene/83332:Rv1486c ^@ http://purl.uniprot.org/uniprot/P9WLX3 ^@ Molecule Processing ^@ Chain ^@ Uncharacterized protein Rv1486c ^@ http://purl.uniprot.org/annotation/PRO_0000103853 http://togogenome.org/gene/83332:Rv0116c ^@ http://purl.uniprot.org/uniprot/O53638 ^@ Molecule Processing|||Region|||Secondary Structure|||Site ^@ Active Site|||Binding Site|||Chain|||Domain Extent|||Helix|||Signal Peptide|||Strand|||Turn ^@ L,D-transpeptidase 1|||Nucleophile|||Proton donor/acceptor|||YkuD|||covalent ^@ http://purl.uniprot.org/annotation/PRO_0000430332 http://togogenome.org/gene/83332:Rv3235 ^@ http://purl.uniprot.org/uniprot/O05880 ^@ Region ^@ Compositionally Biased Region ^@ Polar residues ^@