http://togogenome.org/gene/9305:S100G ^@ http://purl.uniprot.org/uniprot/A0A7N4UY54 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9305:MFAP3 ^@ http://purl.uniprot.org/uniprot/G3VEW9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:CTBP1 ^@ http://purl.uniprot.org/uniprot/G3WAR2|||http://purl.uniprot.org/uniprot/G3WAR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9305:BARX2 ^@ http://purl.uniprot.org/uniprot/G3VXN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SLC17A6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SPRY2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sprouty family.|||ruffle membrane http://togogenome.org/gene/9305:LOC100924365 ^@ http://purl.uniprot.org/uniprot/G3VPR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IL6R ^@ http://purl.uniprot.org/uniprot/G3WLK1 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9305:GDF9 ^@ http://purl.uniprot.org/uniprot/G3WI32 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9305:ND6 ^@ http://purl.uniprot.org/uniprot/G1FKC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9305:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/G3W7M1|||http://purl.uniprot.org/uniprot/G3W7M2 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9305:SPOP ^@ http://purl.uniprot.org/uniprot/A0A7N4PZC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9305:PNMT ^@ http://purl.uniprot.org/uniprot/A0A7N4PKM4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9305:CCDC90B ^@ http://purl.uniprot.org/uniprot/G3VEI3 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9305:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V519 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9305:NTMT1 ^@ http://purl.uniprot.org/uniprot/G3WAY1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9305:SYNE3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN44 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9305:TCP11L2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDJ9 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9305:SVOP ^@ http://purl.uniprot.org/uniprot/G3WDW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9305:INPP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYJ6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9305:CDH12 ^@ http://purl.uniprot.org/uniprot/G3W548 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CBS ^@ http://purl.uniprot.org/uniprot/A0A7N4NYN7 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9305:CLUAP1 ^@ http://purl.uniprot.org/uniprot/G3WRK6|||http://purl.uniprot.org/uniprot/G3WRK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9305:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V747|||http://purl.uniprot.org/uniprot/G3W9I6 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9305:CWC25 ^@ http://purl.uniprot.org/uniprot/G3WY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/9305:LOC100921013 ^@ http://purl.uniprot.org/uniprot/G3VXL3|||http://purl.uniprot.org/uniprot/G3VXL4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9305:PLOD2 ^@ http://purl.uniprot.org/uniprot/G3WYU3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9305:SELL ^@ http://purl.uniprot.org/uniprot/A0A7N4V5X1|||http://purl.uniprot.org/uniprot/G3W9F5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:SPTLC3 ^@ http://purl.uniprot.org/uniprot/G3W945 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9305:LOC116419006 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWS5|||http://purl.uniprot.org/uniprot/A0A7N4UY15 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9305:LOC100934514 ^@ http://purl.uniprot.org/uniprot/G3WD05 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:GBA ^@ http://purl.uniprot.org/uniprot/G3W179 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 30 family.|||Lysosome membrane http://togogenome.org/gene/9305:METTL2A ^@ http://purl.uniprot.org/uniprot/A0A7N4PKX9|||http://purl.uniprot.org/uniprot/G3VJH1 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9305:CCNY ^@ http://purl.uniprot.org/uniprot/A0A7N4PML3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9305:LOC100925518 ^@ http://purl.uniprot.org/uniprot/G3VE78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ODR4 ^@ http://purl.uniprot.org/uniprot/G3WS48 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9305:LOC100931389 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CHMP4A ^@ http://purl.uniprot.org/uniprot/A0A7N4V7P0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9305:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9305:LOC100919708 ^@ http://purl.uniprot.org/uniprot/G3VHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100930807 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:WASHC1 ^@ http://purl.uniprot.org/uniprot/G3WP97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9305:TMEM33 ^@ http://purl.uniprot.org/uniprot/G3WPE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9305:CHAC2 ^@ http://purl.uniprot.org/uniprot/G3WPZ6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9305:LOC100915447 ^@ http://purl.uniprot.org/uniprot/G3WM46 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9305:KHDC4 ^@ http://purl.uniprot.org/uniprot/G3WHD1 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/9305:NMBR ^@ http://purl.uniprot.org/uniprot/G3VSN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PPP1R1A ^@ http://purl.uniprot.org/uniprot/G3WGS6 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9305:SPRY1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sprouty family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9305:SEC61A2 ^@ http://purl.uniprot.org/uniprot/G3W5D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:AVIL ^@ http://purl.uniprot.org/uniprot/G3W7C3 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9305:KRR1 ^@ http://purl.uniprot.org/uniprot/G3VF94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9305:IMPACT ^@ http://purl.uniprot.org/uniprot/A0A7N4PEV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/9305:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM36|||http://purl.uniprot.org/uniprot/G3VZQ2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:CER1 ^@ http://purl.uniprot.org/uniprot/G3WY53 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:DGLUCY ^@ http://purl.uniprot.org/uniprot/G3WIZ8 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9305:CHRNA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:ARRDC3 ^@ http://purl.uniprot.org/uniprot/G3WH02 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9305:PEX7 ^@ http://purl.uniprot.org/uniprot/G3WMB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Cytoplasm http://togogenome.org/gene/9305:ATP5F1A ^@ http://purl.uniprot.org/uniprot/G3WXU6 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9305:PSD4 ^@ http://purl.uniprot.org/uniprot/G3WDA0|||http://purl.uniprot.org/uniprot/G3WDA1 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9305:RPS20 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJW7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9305:LOC100919663 ^@ http://purl.uniprot.org/uniprot/A0A7N4PP98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9305:CASR ^@ http://purl.uniprot.org/uniprot/G3WHI5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUQ7|||http://purl.uniprot.org/uniprot/G3VLT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:HTR2A ^@ http://purl.uniprot.org/uniprot/G3W3N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/9305:TUBB4B ^@ http://purl.uniprot.org/uniprot/A0A7N4V388|||http://purl.uniprot.org/uniprot/G3W1X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9305:NOX4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLA0|||http://purl.uniprot.org/uniprot/G3VR45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SLC39A8 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4N0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PCNA ^@ http://purl.uniprot.org/uniprot/A0A7N4V2Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9305:LOC100916674 ^@ http://purl.uniprot.org/uniprot/G3VSG7 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9305:PLLP ^@ http://purl.uniprot.org/uniprot/G3WNY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GAD1 ^@ http://purl.uniprot.org/uniprot/G3WDA8 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9305:AWAT2 ^@ http://purl.uniprot.org/uniprot/G3W0E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:LOC100917158 ^@ http://purl.uniprot.org/uniprot/G3VTN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100913664 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRX4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9305:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1I5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9305:DOLPP1 ^@ http://purl.uniprot.org/uniprot/G3X3U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9305:PAQR8 ^@ http://purl.uniprot.org/uniprot/G3WKB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:UBE2N ^@ http://purl.uniprot.org/uniprot/A0A7N4NHS9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9305:PLAU ^@ http://purl.uniprot.org/uniprot/G3W3Y6 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. http://togogenome.org/gene/9305:NPM3 ^@ http://purl.uniprot.org/uniprot/G3W389 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9305:AOX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZY8|||http://purl.uniprot.org/uniprot/G3WVK3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9305:CC2D1A ^@ http://purl.uniprot.org/uniprot/G3W9K7|||http://purl.uniprot.org/uniprot/G3W9K8 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/9305:VEGFD ^@ http://purl.uniprot.org/uniprot/G3VQP3 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9305:NKX3-1 ^@ http://purl.uniprot.org/uniprot/G3WS21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100928062 ^@ http://purl.uniprot.org/uniprot/G3VI51 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:SRD5A2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9305:LOC100924887 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ATP5MG ^@ http://purl.uniprot.org/uniprot/A0A7N4PNJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9305:LOC100925430 ^@ http://purl.uniprot.org/uniprot/G3VQT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ARRB2 ^@ http://purl.uniprot.org/uniprot/G3VAC5 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9305:GCDH ^@ http://purl.uniprot.org/uniprot/G3WR30 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9305:CD99 ^@ http://purl.uniprot.org/uniprot/A0A7N4PR11 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9305:LOC100923433 ^@ http://purl.uniprot.org/uniprot/G3WUI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Microsome membrane http://togogenome.org/gene/9305:LOC100924334 ^@ http://purl.uniprot.org/uniprot/G3VHA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:A2M ^@ http://purl.uniprot.org/uniprot/G3VI84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9305:LOC100922043 ^@ http://purl.uniprot.org/uniprot/G3VEH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100915155 ^@ http://purl.uniprot.org/uniprot/G3VWF0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:CDC123 ^@ http://purl.uniprot.org/uniprot/G3W7K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9305:SLC34A3 ^@ http://purl.uniprot.org/uniprot/G3W2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100916737 ^@ http://purl.uniprot.org/uniprot/G3VFV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:ASB17 ^@ http://purl.uniprot.org/uniprot/G3VXA7 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9305:LOC100917840 ^@ http://purl.uniprot.org/uniprot/A0A7N4P369 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9305:DEGS2 ^@ http://purl.uniprot.org/uniprot/G3WRA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSL9 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9305:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A7N4P5U5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9305:NSA2 ^@ http://purl.uniprot.org/uniprot/G3WZG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/9305:PDIK1L ^@ http://purl.uniprot.org/uniprot/G3W421 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:CFAP298 ^@ http://purl.uniprot.org/uniprot/G3W6P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9305:RDH13 ^@ http://purl.uniprot.org/uniprot/G3VHT0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:PLET1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSV7 ^@ Function ^@ Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. http://togogenome.org/gene/9305:LOC100924515 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CTSB ^@ http://purl.uniprot.org/uniprot/G3W5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9305:IBSP ^@ http://purl.uniprot.org/uniprot/G3VPY7 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9305:BDKRB1 ^@ http://purl.uniprot.org/uniprot/G3VUF0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9305:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXU5|||http://purl.uniprot.org/uniprot/G3X150 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9305:BSX ^@ http://purl.uniprot.org/uniprot/A0A7N4NKV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PDLIM3 ^@ http://purl.uniprot.org/uniprot/G3WFZ3|||http://purl.uniprot.org/uniprot/G3WFZ4 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9305:CA14 ^@ http://purl.uniprot.org/uniprot/G3W4T4 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9305:CCN3 ^@ http://purl.uniprot.org/uniprot/G3WY44 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:CNGA4 ^@ http://purl.uniprot.org/uniprot/G3VKE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:POLR2K ^@ http://purl.uniprot.org/uniprot/A0A7N4P3Q7 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9305:PDIA3 ^@ http://purl.uniprot.org/uniprot/G3WNM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9305:CA10 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1G9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9305:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:APP ^@ http://purl.uniprot.org/uniprot/G3VGV4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle|||Early endosome|||Endoplasmic reticulum|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Secreted|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9305:LOC100915965 ^@ http://purl.uniprot.org/uniprot/G3WFZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CCNT1 ^@ http://purl.uniprot.org/uniprot/G3VXD0 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin C subfamily. http://togogenome.org/gene/9305:LOC100916784 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q053 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/9305:YJU2 ^@ http://purl.uniprot.org/uniprot/G3W9R5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/9305:CALCRL ^@ http://purl.uniprot.org/uniprot/A0A7N4PKP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9305:MMAA ^@ http://purl.uniprot.org/uniprot/G3VR08 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9305:CENPA ^@ http://purl.uniprot.org/uniprot/G3W9B0 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9305:CD2 ^@ http://purl.uniprot.org/uniprot/G3WZT7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:LIPT1 ^@ http://purl.uniprot.org/uniprot/G3W3X3 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9305:LOC100917932 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HAPLN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXA6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LGI1 ^@ http://purl.uniprot.org/uniprot/G3WVC8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:INTS13 ^@ http://purl.uniprot.org/uniprot/A0A7N4PG55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:LOC100915322 ^@ http://purl.uniprot.org/uniprot/G3WNV3 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9305:CPSF3 ^@ http://purl.uniprot.org/uniprot/G3VY42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:HDC ^@ http://purl.uniprot.org/uniprot/G3WC78 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9305:DUSP9 ^@ http://purl.uniprot.org/uniprot/G3W0X4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9305:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKD6|||http://purl.uniprot.org/uniprot/A0A7N4Q094 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZQ9|||http://purl.uniprot.org/uniprot/G3VU84 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9305:BASP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ99 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/9305:OLFM4 ^@ http://purl.uniprot.org/uniprot/G3WXX4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:CCNB2 ^@ http://purl.uniprot.org/uniprot/G3WPD4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9305:SLC25A15 ^@ http://purl.uniprot.org/uniprot/G3W0M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9305:CALB1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2M2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.|||Interacts with RANBP9. http://togogenome.org/gene/9305:DNASE1 ^@ http://purl.uniprot.org/uniprot/G3WP67 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9305:LOC100928117 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CLCA2 ^@ http://purl.uniprot.org/uniprot/G3VY26 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9305:RNASEH2B ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0J0|||http://purl.uniprot.org/uniprot/G3WUG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/9305:STAM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9305:FAM163A ^@ http://purl.uniprot.org/uniprot/A0A7N4NFQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9305:GRAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRG3 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/9305:SLC25A51 ^@ http://purl.uniprot.org/uniprot/A0A7N4PC66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:GABRR2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS30 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:C1H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0S6 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9305:GALNT16 ^@ http://purl.uniprot.org/uniprot/G3VX26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:LOC100926074 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RARS2 ^@ http://purl.uniprot.org/uniprot/G3WA78 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:RHCG ^@ http://purl.uniprot.org/uniprot/G3WNU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9305:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P183|||http://purl.uniprot.org/uniprot/G3VMU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:TSPAN17 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:LOC100914950 ^@ http://purl.uniprot.org/uniprot/G3W5I9 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9305:HOXD10 ^@ http://purl.uniprot.org/uniprot/G3WTV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9305:P2RX3 ^@ http://purl.uniprot.org/uniprot/G3WNT8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9305:STARD5 ^@ http://purl.uniprot.org/uniprot/A0A7N4V068 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9305:CDC42 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9305:HSD17B13 ^@ http://purl.uniprot.org/uniprot/G3VDR1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:IWS1 ^@ http://purl.uniprot.org/uniprot/G3VFB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:NID2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8D1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9305:KCNG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:NKAIN4 ^@ http://purl.uniprot.org/uniprot/G3W658 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100933824 ^@ http://purl.uniprot.org/uniprot/G3WR51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9305:LOC100925546 ^@ http://purl.uniprot.org/uniprot/G3X112 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PPP1R14D ^@ http://purl.uniprot.org/uniprot/G3WTH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9305:SLU7 ^@ http://purl.uniprot.org/uniprot/G3W7P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9305:RUNX1 ^@ http://purl.uniprot.org/uniprot/G3WPP2 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9305:LOC100924962 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRL3 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9305:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY70 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A7N4UZW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9305:ATP5MF ^@ http://purl.uniprot.org/uniprot/A0A7N4V4J9 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/9305:NDUFS4 ^@ http://purl.uniprot.org/uniprot/G3W7E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:LOC100919984 ^@ http://purl.uniprot.org/uniprot/G3VU07 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:HACD4 ^@ http://purl.uniprot.org/uniprot/G3WYT8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100925390 ^@ http://purl.uniprot.org/uniprot/G3W948 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9305:WDR55 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/9305:SERINC1 ^@ http://purl.uniprot.org/uniprot/G3WKV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9305:PEX19 ^@ http://purl.uniprot.org/uniprot/A0A7N4PW88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9305:GDI2 ^@ http://purl.uniprot.org/uniprot/G3W4Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9305:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQM6|||http://purl.uniprot.org/uniprot/G3WRV5 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9305:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9305:LOC100919379 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||May act as a zinc-influx transporter.|||Membrane http://togogenome.org/gene/9305:MPEG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V194|||http://purl.uniprot.org/uniprot/G3VC57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9305:LOC100932782 ^@ http://purl.uniprot.org/uniprot/G3WM57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LUM ^@ http://purl.uniprot.org/uniprot/G3VSV0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to laminin.|||extracellular matrix http://togogenome.org/gene/9305:CEBPE ^@ http://purl.uniprot.org/uniprot/G3WLZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9305:VDAC3 ^@ http://purl.uniprot.org/uniprot/G3X0H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic mitochondrial porin family.|||Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.|||Interacts with ARMC12 in a TBC1D21-dependent manner.|||Mitochondrion outer membrane http://togogenome.org/gene/9305:RDH8 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/9305:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3U3 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9305:TIGD6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJG1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100915128 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLD7 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9305:LOC100918197 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100931259 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:GPR37 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ43 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100916272 ^@ http://purl.uniprot.org/uniprot/G3X337 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9305:NCOA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS31|||http://purl.uniprot.org/uniprot/G3VKH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9305:FAM120B ^@ http://purl.uniprot.org/uniprot/A0A7N4NYR3 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9305:FAM163B ^@ http://purl.uniprot.org/uniprot/A0A7N4UXQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9305:TAP2 ^@ http://purl.uniprot.org/uniprot/G3VDD0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. http://togogenome.org/gene/9305:TSPO2 ^@ http://purl.uniprot.org/uniprot/G3WZS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9305:FAM122B ^@ http://purl.uniprot.org/uniprot/G3WB29 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9305:ZC3H15 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1Q3|||http://purl.uniprot.org/uniprot/G3W1U2 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/9305:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1Z4|||http://purl.uniprot.org/uniprot/G3WFM8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:SLC6A7 ^@ http://purl.uniprot.org/uniprot/G3WY95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9305:LOC100917008 ^@ http://purl.uniprot.org/uniprot/G3WC44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HSPA14 ^@ http://purl.uniprot.org/uniprot/G3X250 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9305:IFT43 ^@ http://purl.uniprot.org/uniprot/A0A7N4V189 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9305:LOC100926602 ^@ http://purl.uniprot.org/uniprot/G3WPT4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9305:CFD ^@ http://purl.uniprot.org/uniprot/A0A7N4V4J2 ^@ Function ^@ Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. http://togogenome.org/gene/9305:PMPCB ^@ http://purl.uniprot.org/uniprot/G3VDB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.|||Mitochondrion matrix http://togogenome.org/gene/9305:AP3B1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5P0|||http://purl.uniprot.org/uniprot/G3WY03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9305:REXO2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY53 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9305:GPR107 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPR1|||http://purl.uniprot.org/uniprot/G3WKN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100915652 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7P9|||http://purl.uniprot.org/uniprot/G3W2J1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Component of the 40S small ribosomal subunit.|||Rough endoplasmic reticulum http://togogenome.org/gene/9305:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSC2|||http://purl.uniprot.org/uniprot/A0A7N4PYN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9305:COLGALT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0R8 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9305:UBE2B ^@ http://purl.uniprot.org/uniprot/A0A7N4NNV8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9305:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PS37|||http://purl.uniprot.org/uniprot/G3VEG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9305:CUL5 ^@ http://purl.uniprot.org/uniprot/G3WFH2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9305:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A7N4PB44 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9305:TNFRSF6B ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ43 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100914456 ^@ http://purl.uniprot.org/uniprot/G3VK56 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100921718 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100923196 ^@ http://purl.uniprot.org/uniprot/G3VVI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EXOC1 ^@ http://purl.uniprot.org/uniprot/G3W5Q7|||http://purl.uniprot.org/uniprot/G3W5Q8 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9305:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P172 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9305:DDX31 ^@ http://purl.uniprot.org/uniprot/G3X3H2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9305:COX1 ^@ http://purl.uniprot.org/uniprot/G1FKC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/G3VIA5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9305:LOC100913330 ^@ http://purl.uniprot.org/uniprot/G3VWR8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9305:PPARD ^@ http://purl.uniprot.org/uniprot/A0A7N4NN99|||http://purl.uniprot.org/uniprot/A0A7N4PLD5|||http://purl.uniprot.org/uniprot/G3WB48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:MLST8 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVB7|||http://purl.uniprot.org/uniprot/G3WWQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9305:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A7N4PLC2|||http://purl.uniprot.org/uniprot/G3VTI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9305:SLC25A4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PK42|||http://purl.uniprot.org/uniprot/G3VCY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9305:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A7N4PAW9 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9305:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A7N4V578 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:TSHB ^@ http://purl.uniprot.org/uniprot/G3WD21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9305:LLPH ^@ http://purl.uniprot.org/uniprot/A0A7N4PT62 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9305:GPD2 ^@ http://purl.uniprot.org/uniprot/G3WLA1 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/9305:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A7N4V576 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9305:EFNB3 ^@ http://purl.uniprot.org/uniprot/G3WRN7 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVB4 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9305:LOC105750536 ^@ http://purl.uniprot.org/uniprot/G3WLV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:SLC2A6 ^@ http://purl.uniprot.org/uniprot/G3VXJ7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9305:SAT1 ^@ http://purl.uniprot.org/uniprot/G3W771 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family.|||Homodimer. http://togogenome.org/gene/9305:CSRNP3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9305:LOC100924781 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CCN5 ^@ http://purl.uniprot.org/uniprot/G3W7V5 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9305:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJA3|||http://purl.uniprot.org/uniprot/G3WC12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:STAR ^@ http://purl.uniprot.org/uniprot/G3WXW3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9305:BZW1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVW0 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9305:LOC100934546 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:INSL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NW71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. http://togogenome.org/gene/9305:LOC100921885 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DHRS7C ^@ http://purl.uniprot.org/uniprot/G3VGD9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:S100Z ^@ http://purl.uniprot.org/uniprot/A0A7N4NPU4 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9305:LOC100930070 ^@ http://purl.uniprot.org/uniprot/G3VFQ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9305:MMP14 ^@ http://purl.uniprot.org/uniprot/G3WH26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9305:LOC100913808 ^@ http://purl.uniprot.org/uniprot/G3W4B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/G3VTI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9305:EED ^@ http://purl.uniprot.org/uniprot/G3WKF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ESC family.|||Nucleus http://togogenome.org/gene/9305:CPSF2 ^@ http://purl.uniprot.org/uniprot/G3W9U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9305:DMGDH ^@ http://purl.uniprot.org/uniprot/G3WQF5 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9305:EPHA1 ^@ http://purl.uniprot.org/uniprot/G3VXD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100930478 ^@ http://purl.uniprot.org/uniprot/G3W8B8 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9305:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A7N4PJT8|||http://purl.uniprot.org/uniprot/G3WX77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A7N4UXZ8|||http://purl.uniprot.org/uniprot/G3X284 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9305:C3H2orf49 ^@ http://purl.uniprot.org/uniprot/G3X218 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9305:CSTB ^@ http://purl.uniprot.org/uniprot/A0A7N4V3D9 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9305:LOC100932860 ^@ http://purl.uniprot.org/uniprot/G3VIT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9305:IGFBP1 ^@ http://purl.uniprot.org/uniprot/G3VK90 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:NFU1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCW8 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9305:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFK5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9305:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9305:SGPL1 ^@ http://purl.uniprot.org/uniprot/G3W3D1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9305:EDA2R ^@ http://purl.uniprot.org/uniprot/G3W2V0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:SH2B1 ^@ http://purl.uniprot.org/uniprot/G3WFN7 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9305:CKAP2 ^@ http://purl.uniprot.org/uniprot/G3W865 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9305:LOC100923001 ^@ http://purl.uniprot.org/uniprot/G3VEE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:KCND2 ^@ http://purl.uniprot.org/uniprot/G3VYU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9305:RC3H2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJR8|||http://purl.uniprot.org/uniprot/G3VZP9 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9305:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ04 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:LOC100924488 ^@ http://purl.uniprot.org/uniprot/G3VXC8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:F13B ^@ http://purl.uniprot.org/uniprot/G3VDY8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100918637 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:PRKAR1B ^@ http://purl.uniprot.org/uniprot/G3WA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100928280 ^@ http://purl.uniprot.org/uniprot/G3VTI3|||http://purl.uniprot.org/uniprot/G3W1M2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9305:SCD ^@ http://purl.uniprot.org/uniprot/G3VF96 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9305:GPC3 ^@ http://purl.uniprot.org/uniprot/G3VD75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/9305:LOC100928083 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0S2 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9305:LOC100933077 ^@ http://purl.uniprot.org/uniprot/G3WRS6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:ELF5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PW60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:MYB ^@ http://purl.uniprot.org/uniprot/A0A7N4P7K7|||http://purl.uniprot.org/uniprot/G3WPH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ACVR2A ^@ http://purl.uniprot.org/uniprot/G3W8S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9305:ISM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ65 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9305:CCN2 ^@ http://purl.uniprot.org/uniprot/G3WBU2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:SARS1 ^@ http://purl.uniprot.org/uniprot/G3X052 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9305:MNS1 ^@ http://purl.uniprot.org/uniprot/G3WZM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9305:FITM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. http://togogenome.org/gene/9305:DCLRE1C ^@ http://purl.uniprot.org/uniprot/G3X2C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9305:LOC100919937 ^@ http://purl.uniprot.org/uniprot/G3VMQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:FAXC ^@ http://purl.uniprot.org/uniprot/A0A7N4P8D3 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9305:LOC100924139 ^@ http://purl.uniprot.org/uniprot/G3W6G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CRHBP ^@ http://purl.uniprot.org/uniprot/G3VXK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9305:PSMA8 ^@ http://purl.uniprot.org/uniprot/G3WX18 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9305:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9305:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A7N4NZG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:COPS7A ^@ http://purl.uniprot.org/uniprot/G3WS15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:MRPL43 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/9305:MFSD6 ^@ http://purl.uniprot.org/uniprot/G3WRF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9305:BTD ^@ http://purl.uniprot.org/uniprot/A0A7N4P1G9 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9305:LOC100927348 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT30 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC100930597 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PAU1 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9305:PKN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9305:HSD17B2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGI3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:METTL6 ^@ http://purl.uniprot.org/uniprot/G3VW57 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9305:WASHC3 ^@ http://purl.uniprot.org/uniprot/G3VIX2 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9305:TSPAN11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIT4|||http://purl.uniprot.org/uniprot/G3WA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:LOC100921604 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100917673 ^@ http://purl.uniprot.org/uniprot/G3VVI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TMEM38A ^@ http://purl.uniprot.org/uniprot/A0A7N4PNG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9305:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/G3VPG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9305:LOC100922300 ^@ http://purl.uniprot.org/uniprot/G3VGK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EVA1C ^@ http://purl.uniprot.org/uniprot/G3VEV1 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9305:LOC100916591 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).|||Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9305:LOC100934553 ^@ http://purl.uniprot.org/uniprot/G3WZP4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:SPO11 ^@ http://purl.uniprot.org/uniprot/G3VC58 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9305:LMOD2 ^@ http://purl.uniprot.org/uniprot/G3W7C1 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9305:FGR ^@ http://purl.uniprot.org/uniprot/G3VEY1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:FGFBP2 ^@ http://purl.uniprot.org/uniprot/G3X269 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9305:IFRD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1L5 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9305:MTERF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQY9 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9305:FMNL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFZ3|||http://purl.uniprot.org/uniprot/G3VRC4 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9305:PLBD1 ^@ http://purl.uniprot.org/uniprot/G3WYC5 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9305:ATPSCKMT ^@ http://purl.uniprot.org/uniprot/A0A7N4NW72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/9305:DCPS ^@ http://purl.uniprot.org/uniprot/G3VH86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9305:TMEM218 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9305:BROX ^@ http://purl.uniprot.org/uniprot/A0A7N4V7B9|||http://purl.uniprot.org/uniprot/G3W5N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BROX family.|||Membrane http://togogenome.org/gene/9305:NIFK ^@ http://purl.uniprot.org/uniprot/G3WED0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:SATB1 ^@ http://purl.uniprot.org/uniprot/G3WRP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC100924624 ^@ http://purl.uniprot.org/uniprot/G3VQH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CDH18 ^@ http://purl.uniprot.org/uniprot/G3VZE2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPS9|||http://purl.uniprot.org/uniprot/G3W1X0 ^@ Caution|||Similarity ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0Q2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:POMC ^@ http://purl.uniprot.org/uniprot/A0A7N4NUF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Belongs to the POMC family.|||Endogenous opiate.|||Endogenous orexigenic opiate.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/9305:SNF8 ^@ http://purl.uniprot.org/uniprot/G3WLY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/9305:STARD6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2E6 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9305:SNAP47 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZH1|||http://purl.uniprot.org/uniprot/G3W5G0 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/9305:LOC100928980 ^@ http://purl.uniprot.org/uniprot/G3VLK2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJN3|||http://purl.uniprot.org/uniprot/G3VS31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100913481 ^@ http://purl.uniprot.org/uniprot/A0A7N4PB35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:TAF7L ^@ http://purl.uniprot.org/uniprot/A0A7N4PA98|||http://purl.uniprot.org/uniprot/G3WL50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9305:EFEMP1 ^@ http://purl.uniprot.org/uniprot/G3WI99 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A7N4NK77|||http://purl.uniprot.org/uniprot/G3W100 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9305:NCOA7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDT7|||http://purl.uniprot.org/uniprot/G3WW09 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9305:MRPS23 ^@ http://purl.uniprot.org/uniprot/G3VWQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS23 family.|||Mitochondrion http://togogenome.org/gene/9305:ASF1B ^@ http://purl.uniprot.org/uniprot/G3W518 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9305:CASP10 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6N5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9305:LOC100917414 ^@ http://purl.uniprot.org/uniprot/G3VUF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LETM1 ^@ http://purl.uniprot.org/uniprot/G3W3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:CD55 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFP9|||http://purl.uniprot.org/uniprot/G3X2Y3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:CAPN1 ^@ http://purl.uniprot.org/uniprot/G3VKY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9305:DUSP27 ^@ http://purl.uniprot.org/uniprot/G3X249 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9305:LOC100928205 ^@ http://purl.uniprot.org/uniprot/G3VW86 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:SEC22C ^@ http://purl.uniprot.org/uniprot/G3W5T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9305:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/G3WA14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9305:AKAP5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ERGIC1 ^@ http://purl.uniprot.org/uniprot/G3VPI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9305:TBC1D7 ^@ http://purl.uniprot.org/uniprot/G3W592 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9305:ADAMDEC1 ^@ http://purl.uniprot.org/uniprot/G3WF19 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:JPH1 ^@ http://purl.uniprot.org/uniprot/G3VWL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9305:SLC12A9 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1X4|||http://purl.uniprot.org/uniprot/G3VZW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100926719 ^@ http://purl.uniprot.org/uniprot/A0A7N4NR34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRAME family. LRRC14 subfamily.|||Cytoplasm http://togogenome.org/gene/9305:CCN1 ^@ http://purl.uniprot.org/uniprot/G3WHV5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:CDADC1 ^@ http://purl.uniprot.org/uniprot/G3W657 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9305:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/G3WLK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9305:CCR10 ^@ http://purl.uniprot.org/uniprot/G3WKR2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LOC100915501 ^@ http://purl.uniprot.org/uniprot/G3WTT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ANKRD34B ^@ http://purl.uniprot.org/uniprot/A0A7N4V4X9 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9305:RPRM ^@ http://purl.uniprot.org/uniprot/A0A7N4PWD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reprimo family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9305:TMEM163 ^@ http://purl.uniprot.org/uniprot/G3WMI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Early endosome membrane|||Endosome membrane|||May bind zinc and other divalent cations and recruit them to vesicular organelles.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9305:KIF18B ^@ http://purl.uniprot.org/uniprot/G3W437 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:LOC100916127 ^@ http://purl.uniprot.org/uniprot/G3WUW9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:CLTRN ^@ http://purl.uniprot.org/uniprot/G3WLD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100915272 ^@ http://purl.uniprot.org/uniprot/G3VCN9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9305:MED21 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9305:DDX18 ^@ http://purl.uniprot.org/uniprot/G3X3E5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. http://togogenome.org/gene/9305:WNT3 ^@ http://purl.uniprot.org/uniprot/G3WLF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:TMEM45A ^@ http://purl.uniprot.org/uniprot/G3VP58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9305:TPX2 ^@ http://purl.uniprot.org/uniprot/G3WJN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9305:LOC100920242 ^@ http://purl.uniprot.org/uniprot/G3VI21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100915323 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100922672 ^@ http://purl.uniprot.org/uniprot/G3VQ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ICOS ^@ http://purl.uniprot.org/uniprot/A0A7N4PM64|||http://purl.uniprot.org/uniprot/G3WT94 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9305:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM23|||http://purl.uniprot.org/uniprot/G3W7S3 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9305:GLYATL3 ^@ http://purl.uniprot.org/uniprot/G3VNU7 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9305:LOC100920753 ^@ http://purl.uniprot.org/uniprot/G3VI12 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9305:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1F2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9305:CAPN3 ^@ http://purl.uniprot.org/uniprot/G3VZS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9305:SLC26A1 ^@ http://purl.uniprot.org/uniprot/G3WPW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.|||Membrane http://togogenome.org/gene/9305:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9305:ATP6 ^@ http://purl.uniprot.org/uniprot/G1FKC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:FAM102A ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ14 ^@ Similarity ^@ Belongs to the FAM102 family. http://togogenome.org/gene/9305:LOC100933477 ^@ http://purl.uniprot.org/uniprot/G3VL95 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A7N4NHB9|||http://purl.uniprot.org/uniprot/G3VVB6 ^@ Similarity ^@ Belongs to the TENT family.|||Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9305:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A7N4NGT6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9305:GABRA4 ^@ http://purl.uniprot.org/uniprot/G3W8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:LOC100923826 ^@ http://purl.uniprot.org/uniprot/G3VPD0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:ORM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9305:FOXI1 ^@ http://purl.uniprot.org/uniprot/G3X2P6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100915842 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PLD2 ^@ http://purl.uniprot.org/uniprot/G3VJE2 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9305:TAAR5 ^@ http://purl.uniprot.org/uniprot/G3VUD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9305:SLC7A11 ^@ http://purl.uniprot.org/uniprot/G3WGE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/9305:PLIN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PA51 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9305:SLC5A6 ^@ http://purl.uniprot.org/uniprot/G3WGU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9305:CFAP206 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0V8|||http://purl.uniprot.org/uniprot/G3W7I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9305:CNTF ^@ http://purl.uniprot.org/uniprot/A0A7N4P4Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9305:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0R5 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9305:SPG7 ^@ http://purl.uniprot.org/uniprot/G3WS00 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9305:CHRM2 ^@ http://purl.uniprot.org/uniprot/G3VX75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9305:TMCO3 ^@ http://purl.uniprot.org/uniprot/G3WT35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:KCNAB3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUH1|||http://purl.uniprot.org/uniprot/A0A7N4PF26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100918111 ^@ http://purl.uniprot.org/uniprot/G3W4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HAL ^@ http://purl.uniprot.org/uniprot/A0A7N4UY41|||http://purl.uniprot.org/uniprot/G3WHS2 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9305:GASK1B ^@ http://purl.uniprot.org/uniprot/G3WRS9 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9305:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A7N4PZ51 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9305:LOC100918039 ^@ http://purl.uniprot.org/uniprot/G3W9G4 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/9305:TEX10 ^@ http://purl.uniprot.org/uniprot/G3W910 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9305:NR2C1 ^@ http://purl.uniprot.org/uniprot/G3VMA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:KIF23 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYD1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:LOC100919276 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100929673 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0A1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:ATP5PO ^@ http://purl.uniprot.org/uniprot/G3VBA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:LOC100920453 ^@ http://purl.uniprot.org/uniprot/G3WZU8 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/9305:RBKS ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ42 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9305:PLPBP ^@ http://purl.uniprot.org/uniprot/A0A7N4NFG9|||http://purl.uniprot.org/uniprot/G3WVA8 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9305:CAV1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9305:PDGFD ^@ http://purl.uniprot.org/uniprot/A0A7N4V4P0 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the PDGF/VEGF growth factor family.|||Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:RAB27B ^@ http://purl.uniprot.org/uniprot/G3WXN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9305:SLC39A12 ^@ http://purl.uniprot.org/uniprot/G3WED6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9305:KCNG3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6R8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100922659 ^@ http://purl.uniprot.org/uniprot/G3VNX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:HRH3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPQ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:VWC2L ^@ http://purl.uniprot.org/uniprot/G3WP94 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9305:NPRL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V759 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/9305:CBY2 ^@ http://purl.uniprot.org/uniprot/G3W232 ^@ Similarity|||Subunit ^@ Belongs to the chibby family. SPERT subfamily.|||Homodimer. Binds to NEK1. http://togogenome.org/gene/9305:TELO2 ^@ http://purl.uniprot.org/uniprot/G3WA99 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/9305:LOC100921734 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGF0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:NDC80 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMV7|||http://purl.uniprot.org/uniprot/G3VCQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9305:PHTF1 ^@ http://purl.uniprot.org/uniprot/G3WEV3|||http://purl.uniprot.org/uniprot/G3WEV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CCNH ^@ http://purl.uniprot.org/uniprot/G3WWE0 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9305:LOC100925341 ^@ http://purl.uniprot.org/uniprot/G3VLK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9305:AQP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9305:LOC105749869 ^@ http://purl.uniprot.org/uniprot/G3W529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100915003 ^@ http://purl.uniprot.org/uniprot/G3VAJ0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9305:LOC100930036 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/G3W5X1 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9305:HSPA5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9305:B3GALT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:SLC43A1 ^@ http://purl.uniprot.org/uniprot/G3WR82|||http://purl.uniprot.org/uniprot/G3WR83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SLC30A4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9305:CDC42EP4 ^@ http://purl.uniprot.org/uniprot/G3WSC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9305:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A7N4P668|||http://purl.uniprot.org/uniprot/G3X2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9305:F2RL3 ^@ http://purl.uniprot.org/uniprot/G3VUX6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:TIGD4 ^@ http://purl.uniprot.org/uniprot/G3W0T3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PL11|||http://purl.uniprot.org/uniprot/G3VPS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9305:QPCT ^@ http://purl.uniprot.org/uniprot/G3W588 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9305:LOC100924274 ^@ http://purl.uniprot.org/uniprot/G3VF77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SSTR1 ^@ http://purl.uniprot.org/uniprot/G3VL76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CD5 ^@ http://purl.uniprot.org/uniprot/G3WAW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:TMEM135 ^@ http://purl.uniprot.org/uniprot/G3VRF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9305:SLBP ^@ http://purl.uniprot.org/uniprot/A0A7N4NKA5 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/9305:CFAP126 ^@ http://purl.uniprot.org/uniprot/G3WX54 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9305:GDAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQM9 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/9305:CD163 ^@ http://purl.uniprot.org/uniprot/G3VJT8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:SLC26A9 ^@ http://purl.uniprot.org/uniprot/G3WVG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport.|||Membrane http://togogenome.org/gene/9305:CACNG3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9305:SLC46A3 ^@ http://purl.uniprot.org/uniprot/G3X2H1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GNAQ ^@ http://purl.uniprot.org/uniprot/G3W7B2 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9305:STXBP3 ^@ http://purl.uniprot.org/uniprot/G3WXV5 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9305:TPP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSG9|||http://purl.uniprot.org/uniprot/G3W6M3 ^@ Cofactor ^@ Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9305:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUN7|||http://purl.uniprot.org/uniprot/G3WF58 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9305:LOC100926690 ^@ http://purl.uniprot.org/uniprot/G3WEG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ARRDC1 ^@ http://purl.uniprot.org/uniprot/G3WGP9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9305:LOC100919222 ^@ http://purl.uniprot.org/uniprot/G3WEY5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:NCOA3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9305:LOC100935364 ^@ http://purl.uniprot.org/uniprot/G3WCM8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:UTS2R ^@ http://purl.uniprot.org/uniprot/A0A7N4PJ67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9305:STX7 ^@ http://purl.uniprot.org/uniprot/G3WNI0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9305:PAPPA2 ^@ http://purl.uniprot.org/uniprot/G3W214 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:CD244 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2S3|||http://purl.uniprot.org/uniprot/G3VKD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/G3WLS5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9305:KCNB1 ^@ http://purl.uniprot.org/uniprot/G3VVR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||sarcolemma|||synaptosome http://togogenome.org/gene/9305:MRPS18C ^@ http://purl.uniprot.org/uniprot/G3VYC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9305:ACAA2 ^@ http://purl.uniprot.org/uniprot/G3VDY7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9305:LOC100935001 ^@ http://purl.uniprot.org/uniprot/G3VS46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100918395 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGP2 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/9305:SLITRK5 ^@ http://purl.uniprot.org/uniprot/G3W5F4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9305:DDX59 ^@ http://purl.uniprot.org/uniprot/G3WPP1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9305:ARL2 ^@ http://purl.uniprot.org/uniprot/G3VKZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9305:PGF ^@ http://purl.uniprot.org/uniprot/A0A7N4PZP4|||http://purl.uniprot.org/uniprot/G3X1B7 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9305:LMNB1 ^@ http://purl.uniprot.org/uniprot/G3WGG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9305:FAM214B ^@ http://purl.uniprot.org/uniprot/G3WVR4 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/9305:TTYH2 ^@ http://purl.uniprot.org/uniprot/G3W0G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9305:GPR15 ^@ http://purl.uniprot.org/uniprot/G3VH89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:THEMIS2 ^@ http://purl.uniprot.org/uniprot/G3WQW9 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9305:EIF4E1B ^@ http://purl.uniprot.org/uniprot/G3W0X3 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9305:NKX2-1 ^@ http://purl.uniprot.org/uniprot/G3W6D0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:MINDY1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4S6|||http://purl.uniprot.org/uniprot/G3WIN0 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9305:TMEM39A ^@ http://purl.uniprot.org/uniprot/A0A7N4PTK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9305:SMPDL3A ^@ http://purl.uniprot.org/uniprot/G3VLN6|||http://purl.uniprot.org/uniprot/G3VLN7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9305:NPR3 ^@ http://purl.uniprot.org/uniprot/G3WCY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTF8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9305:GPRC5C ^@ http://purl.uniprot.org/uniprot/G3VJE9|||http://purl.uniprot.org/uniprot/G3VJF0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:SHROOM3 ^@ http://purl.uniprot.org/uniprot/G3W3K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9305:LOC100921866 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TFB2M ^@ http://purl.uniprot.org/uniprot/G3W8D9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/9305:TFAP2C ^@ http://purl.uniprot.org/uniprot/G3WDQ5 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9305:DIS3L ^@ http://purl.uniprot.org/uniprot/G3WBL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNR ribonuclease family.|||Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.|||Cytoplasm|||Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. http://togogenome.org/gene/9305:CLVS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9C9 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9305:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/G3VSU8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:ENO3 ^@ http://purl.uniprot.org/uniprot/G3VUH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100913627 ^@ http://purl.uniprot.org/uniprot/G3WPB5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9305:GHITM ^@ http://purl.uniprot.org/uniprot/G3VX05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9305:RAPSN ^@ http://purl.uniprot.org/uniprot/G3WYM7 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/9305:RSPO2 ^@ http://purl.uniprot.org/uniprot/G3WC93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the R-spondin family.|||Secreted http://togogenome.org/gene/9305:LPAR5 ^@ http://purl.uniprot.org/uniprot/G3WR60 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIW3|||http://purl.uniprot.org/uniprot/G3W7C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9305:OPN4 ^@ http://purl.uniprot.org/uniprot/G3W2U2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:PLRG1 ^@ http://purl.uniprot.org/uniprot/G3WN54 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9305:TMEM161B ^@ http://purl.uniprot.org/uniprot/A0A7N4PTI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9305:ENTPD7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWM0 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9305:CIAO2B ^@ http://purl.uniprot.org/uniprot/A0A7N4NGD7 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9305:LOC100925903 ^@ http://purl.uniprot.org/uniprot/G3VW39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PLXNA4 ^@ http://purl.uniprot.org/uniprot/G3WT00 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LPAR3 ^@ http://purl.uniprot.org/uniprot/G3WUP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TTC21B ^@ http://purl.uniprot.org/uniprot/G3WF32 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9305:TAF13 ^@ http://purl.uniprot.org/uniprot/G3WZF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:DOK5 ^@ http://purl.uniprot.org/uniprot/G3W4P5 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9305:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A7N4NM46 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9305:HOXB1 ^@ http://purl.uniprot.org/uniprot/G3WFK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100919979 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.|||Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9305:RBM8A ^@ http://purl.uniprot.org/uniprot/G3X2V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9305:LOC100931640 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GRM3 ^@ http://purl.uniprot.org/uniprot/G3X3G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9305:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RAD52 ^@ http://purl.uniprot.org/uniprot/G3VQX1|||http://purl.uniprot.org/uniprot/G3VQX2 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/9305:LOC100928456 ^@ http://purl.uniprot.org/uniprot/G3VIU9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9305:HEXIM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9305:CROT ^@ http://purl.uniprot.org/uniprot/A0A7N4PBK0 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9305:DUT ^@ http://purl.uniprot.org/uniprot/A0A7N4PQC6 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/9305:GPR157 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:C1H12orf65 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9305:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYD2|||http://purl.uniprot.org/uniprot/G3WLN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TOM1L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P833|||http://purl.uniprot.org/uniprot/G3WVN8 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9305:TMEM50B ^@ http://purl.uniprot.org/uniprot/A0A7N4PGB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9305:LOC100918656 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GBA2 ^@ http://purl.uniprot.org/uniprot/G3WMQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/9305:LOC100916721 ^@ http://purl.uniprot.org/uniprot/G5EA65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9305:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZN1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9305:AZIN1 ^@ http://purl.uniprot.org/uniprot/G3X2J1 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9305:SPSB3 ^@ http://purl.uniprot.org/uniprot/G3WJU3 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9305:LOC100926477 ^@ http://purl.uniprot.org/uniprot/G3VAY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9305:LOC100929937 ^@ http://purl.uniprot.org/uniprot/G3VCN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CLDN14 ^@ http://purl.uniprot.org/uniprot/G3VXY2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:OTX1 ^@ http://purl.uniprot.org/uniprot/G3WD18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:VGLL2 ^@ http://purl.uniprot.org/uniprot/G3WDJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/9305:PHKG2 ^@ http://purl.uniprot.org/uniprot/G3W787 ^@ Subunit ^@ Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9305:OLFML1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NND2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:USP5 ^@ http://purl.uniprot.org/uniprot/G3WTY6 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9305:LOC100927276 ^@ http://purl.uniprot.org/uniprot/G3WEK8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9305:LOC100925813 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACADSB ^@ http://purl.uniprot.org/uniprot/G3VCY3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9305:BGLAP ^@ http://purl.uniprot.org/uniprot/A0A7N4PPV9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9305:LOC100925756 ^@ http://purl.uniprot.org/uniprot/G3WG85 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5V1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:SFXN2 ^@ http://purl.uniprot.org/uniprot/G3X372 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:SLC34A1 ^@ http://purl.uniprot.org/uniprot/G3WPR4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IRF8 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2J5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:SMAD7 ^@ http://purl.uniprot.org/uniprot/G3WYR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:PRKD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V735 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9305:LOC100920148 ^@ http://purl.uniprot.org/uniprot/A0A7N4NH76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ASF1A ^@ http://purl.uniprot.org/uniprot/G3W4C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9305:PDE6G ^@ http://purl.uniprot.org/uniprot/G3WIX9 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9305:HCK ^@ http://purl.uniprot.org/uniprot/G3WE58 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:KCNH8 ^@ http://purl.uniprot.org/uniprot/G3W1Y1 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9305:C1H9orf64 ^@ http://purl.uniprot.org/uniprot/G3WXZ8 ^@ Function|||Similarity ^@ Belongs to the queuosine salvage protein family.|||Involved in salvaging queuosine. http://togogenome.org/gene/9305:PDC ^@ http://purl.uniprot.org/uniprot/G3WSQ3 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9305:ANXA4 ^@ http://purl.uniprot.org/uniprot/G3WNV2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9305:MAGT1 ^@ http://purl.uniprot.org/uniprot/G3WG52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LOC100916837 ^@ http://purl.uniprot.org/uniprot/G3WRH8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:CMAS ^@ http://purl.uniprot.org/uniprot/G3WLL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/9305:LOC100918853 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100913673 ^@ http://purl.uniprot.org/uniprot/G3WER1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100920922 ^@ http://purl.uniprot.org/uniprot/A0A7N4P6Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACTL6B ^@ http://purl.uniprot.org/uniprot/A0A7N4NGL1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:LOC100927341 ^@ http://purl.uniprot.org/uniprot/G3VQ98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9305:VIPAS39 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLU4 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/9305:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYR1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:RRM2B ^@ http://purl.uniprot.org/uniprot/G3WZC9 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/9305:PSKH2 ^@ http://purl.uniprot.org/uniprot/G3W841 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:HTRA3 ^@ http://purl.uniprot.org/uniprot/G3WT65 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9305:FAM110D ^@ http://purl.uniprot.org/uniprot/G3W5C1 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9305:EMG1 ^@ http://purl.uniprot.org/uniprot/G3WV86 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9305:LOC100914525 ^@ http://purl.uniprot.org/uniprot/G3VKV6 ^@ Similarity|||Subunit ^@ Belongs to the SFTPD family.|||Oligomeric complex of 4 set of homotrimers. http://togogenome.org/gene/9305:LOC100931905 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100923336 ^@ http://purl.uniprot.org/uniprot/G3VJJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ITIH5 ^@ http://purl.uniprot.org/uniprot/G3X008 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9305:LOC100916042 ^@ http://purl.uniprot.org/uniprot/G3W9Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CYRIB ^@ http://purl.uniprot.org/uniprot/G3WJB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9305:LOC100922250 ^@ http://purl.uniprot.org/uniprot/G3W4N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNF2 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/9305:ATP1A2 ^@ http://purl.uniprot.org/uniprot/G3W5F0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LGALS3 ^@ http://purl.uniprot.org/uniprot/G3VNU5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9305:LOC100932082 ^@ http://purl.uniprot.org/uniprot/G3VEX5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9305:LOC100927223 ^@ http://purl.uniprot.org/uniprot/G3W1B0 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9305:LOC100916162 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIY4 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9305:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:IFNG ^@ http://purl.uniprot.org/uniprot/G3WQJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9305:EME1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI39 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9305:VWA2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN05 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:ADCY4 ^@ http://purl.uniprot.org/uniprot/G3VVT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9305:LOC100926346 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYZ5|||http://purl.uniprot.org/uniprot/G3W9D9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9305:PDLIM1 ^@ http://purl.uniprot.org/uniprot/G3WKQ6 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9305:DHRS9 ^@ http://purl.uniprot.org/uniprot/G3WX97 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:BCO1 ^@ http://purl.uniprot.org/uniprot/G3W0D4 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9305:LOC100920064 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TENM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMU8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100914771 ^@ http://purl.uniprot.org/uniprot/G3WI18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:LOC100932984 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3X1|||http://purl.uniprot.org/uniprot/G3X1D9 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9305:PSMB5 ^@ http://purl.uniprot.org/uniprot/G3WKE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:TCTA ^@ http://purl.uniprot.org/uniprot/A0A7N4PJU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9305:TRMT10C ^@ http://purl.uniprot.org/uniprot/G3W497 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9305:ARMC8 ^@ http://purl.uniprot.org/uniprot/G3VYC8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:SUGP1 ^@ http://purl.uniprot.org/uniprot/G3WGC4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:FGGY ^@ http://purl.uniprot.org/uniprot/G3VRY7 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9305:SLC25A47 ^@ http://purl.uniprot.org/uniprot/G3WM98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:LOC100913765 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:AHSA1 ^@ http://purl.uniprot.org/uniprot/G3VQM5 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9305:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/G3VIW1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/G3W920 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/9305:ATG16L2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V4F2|||http://purl.uniprot.org/uniprot/G3VTT0 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9305:ITGA6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:DRD3 ^@ http://purl.uniprot.org/uniprot/G3VZA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/9305:TMEM17 ^@ http://purl.uniprot.org/uniprot/G3WMS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100920969 ^@ http://purl.uniprot.org/uniprot/G3W3S2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9305:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYN8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9305:LMBR1L ^@ http://purl.uniprot.org/uniprot/G3VSI5 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9305:NUDT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIH3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/9305:MPPED2 ^@ http://purl.uniprot.org/uniprot/G3WBR2 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9305:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/G3WA41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9305:ARL11 ^@ http://purl.uniprot.org/uniprot/G3VQU9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9305:LOC100914326 ^@ http://purl.uniprot.org/uniprot/G3WD90 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9305:IL18 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Secreted http://togogenome.org/gene/9305:SERPINI1 ^@ http://purl.uniprot.org/uniprot/G3VI34 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:ZNRD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQ74|||http://purl.uniprot.org/uniprot/G3VEY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/9305:LOC100927922 ^@ http://purl.uniprot.org/uniprot/A0A7N4PY73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ND4L ^@ http://purl.uniprot.org/uniprot/G1FKC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2D6 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9305:COPS9 ^@ http://purl.uniprot.org/uniprot/G3WYG9 ^@ Similarity ^@ Belongs to the CSN9 family. http://togogenome.org/gene/9305:KCNG1 ^@ http://purl.uniprot.org/uniprot/G3X319 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ACTA1 ^@ http://purl.uniprot.org/uniprot/G3WM41 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:XRCC3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJ46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/9305:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9305:POT1 ^@ http://purl.uniprot.org/uniprot/G3WTD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9305:RGS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V115 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||nucleolus http://togogenome.org/gene/9305:LOC100926920 ^@ http://purl.uniprot.org/uniprot/G3VQN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100922640 ^@ http://purl.uniprot.org/uniprot/G3VK96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HTR2B ^@ http://purl.uniprot.org/uniprot/G3VRJ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts (via C-terminus) with MPDZ.|||Membrane|||synaptosome http://togogenome.org/gene/9305:GPLD1 ^@ http://purl.uniprot.org/uniprot/G3VXB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9305:LOC100931010 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RPL32 ^@ http://purl.uniprot.org/uniprot/G3WHS6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9305:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9305:BMX ^@ http://purl.uniprot.org/uniprot/G3VBH5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:ZBED1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A7N4PXH0|||http://purl.uniprot.org/uniprot/G3WW36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:ANP32E ^@ http://purl.uniprot.org/uniprot/A0A7N4V0R9 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/9305:LOC100922493 ^@ http://purl.uniprot.org/uniprot/G3W950 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PSMB10 ^@ http://purl.uniprot.org/uniprot/G3W0G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:ERMAP ^@ http://purl.uniprot.org/uniprot/G3WQ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9305:LEP ^@ http://purl.uniprot.org/uniprot/A0A7N4NJU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9305:PSMC5 ^@ http://purl.uniprot.org/uniprot/G3WIV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/9305:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:PCSK1 ^@ http://purl.uniprot.org/uniprot/G3VJH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9305:TRH ^@ http://purl.uniprot.org/uniprot/A0A7N4NMF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/9305:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A7N4V4H6 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/9305:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/A0A7N4P397 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9305:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/G3WFL4 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9305:CCDC130 ^@ http://purl.uniprot.org/uniprot/G3WDP9 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/9305:MCTP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MARS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRU3|||http://purl.uniprot.org/uniprot/G3VYN2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:LOC100928641 ^@ http://purl.uniprot.org/uniprot/G3VRU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9305:LOC100922169 ^@ http://purl.uniprot.org/uniprot/G3WIJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9305:LOC100914215 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXH3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC100920562 ^@ http://purl.uniprot.org/uniprot/G3VQI3|||http://purl.uniprot.org/uniprot/G3WSM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9305:AGMAT ^@ http://purl.uniprot.org/uniprot/G3W5P0 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/9305:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NH74|||http://purl.uniprot.org/uniprot/G3X317 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9305:LOC100917175 ^@ http://purl.uniprot.org/uniprot/K9HXI3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9305:HOXA1 ^@ http://purl.uniprot.org/uniprot/G3WWK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9305:LTB ^@ http://purl.uniprot.org/uniprot/G3VNG6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9305:SLC16A14 ^@ http://purl.uniprot.org/uniprot/G3X0F6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100929712 ^@ http://purl.uniprot.org/uniprot/G3VG75 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/9305:S1PR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC105750284 ^@ http://purl.uniprot.org/uniprot/G3WIW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SOD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9305:LOC100929289 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FTHL17 ^@ http://purl.uniprot.org/uniprot/G3X002 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9305:ITGA5 ^@ http://purl.uniprot.org/uniprot/G3WC24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:NIPA2 ^@ http://purl.uniprot.org/uniprot/G3VYH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9305:RAG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P622 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9305:LOC100929552 ^@ http://purl.uniprot.org/uniprot/G3W3I5|||http://purl.uniprot.org/uniprot/G3W3Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9305:LOC100927475 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3N9|||http://purl.uniprot.org/uniprot/G3W1A9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9305:CEL ^@ http://purl.uniprot.org/uniprot/G3VZE3 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9305:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A7N4PVA0 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9305:LOC100925879 ^@ http://purl.uniprot.org/uniprot/G3VX64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GJB3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4D7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:MSTN ^@ http://purl.uniprot.org/uniprot/G3WMK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted http://togogenome.org/gene/9305:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9305:LOC100919047 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ53 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9305:CEMIP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PV12|||http://purl.uniprot.org/uniprot/G3VTP2 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9305:RND3 ^@ http://purl.uniprot.org/uniprot/G3WXU2 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9305:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PU65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9305:PER1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIK5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:GPAT3 ^@ http://purl.uniprot.org/uniprot/G3VZS8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9305:UTP15 ^@ http://purl.uniprot.org/uniprot/G3WJV4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PAQ7|||http://purl.uniprot.org/uniprot/A0A7N4PGS0|||http://purl.uniprot.org/uniprot/G3VYU4 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9305:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1S1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9305:LOC100916704 ^@ http://purl.uniprot.org/uniprot/G3VGF4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:AK3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTC5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9305:GADD45B ^@ http://purl.uniprot.org/uniprot/A0A7N4PYY6 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9305:LOC100931665 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IER2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PK74 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9305:SSTR4 ^@ http://purl.uniprot.org/uniprot/G3WHG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNR4 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9305:PKP4 ^@ http://purl.uniprot.org/uniprot/G3X1Y9 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9305:NMB ^@ http://purl.uniprot.org/uniprot/G3WTK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9305:HSPD1 ^@ http://purl.uniprot.org/uniprot/G3WZS7 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9305:MDH2 ^@ http://purl.uniprot.org/uniprot/G3WJR3 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9305:ABHD2 ^@ http://purl.uniprot.org/uniprot/G3WT24 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9305:SLC35F1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NL53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9305:EMC4 ^@ http://purl.uniprot.org/uniprot/G3VT98 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:GGNBP2 ^@ http://purl.uniprot.org/uniprot/G3VRR9 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9305:SRP9 ^@ http://purl.uniprot.org/uniprot/G3WK96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9305:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A7N4PHC9|||http://purl.uniprot.org/uniprot/G3WYS8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9305:NKD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9305:NME4 ^@ http://purl.uniprot.org/uniprot/G3W378 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9305:GPR180 ^@ http://purl.uniprot.org/uniprot/G3WWU9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:EPO ^@ http://purl.uniprot.org/uniprot/G3W289 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9305:SMARCA4 ^@ http://purl.uniprot.org/uniprot/G3VF88|||http://purl.uniprot.org/uniprot/G3VF89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9305:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXM6|||http://purl.uniprot.org/uniprot/G3WVJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PKIB ^@ http://purl.uniprot.org/uniprot/G3VED5 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9305:FABP4 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXM2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:LOC100919718 ^@ http://purl.uniprot.org/uniprot/A0A7N4NP99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NR2F1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:LOC100913242 ^@ http://purl.uniprot.org/uniprot/G3WPZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACSS1 ^@ http://purl.uniprot.org/uniprot/G3VNY8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9305:GDAP2 ^@ http://purl.uniprot.org/uniprot/G3VMC6 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/9305:TLE3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9305:FOXF2 ^@ http://purl.uniprot.org/uniprot/G3WHK3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SMIM5 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q141 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:TNMD ^@ http://purl.uniprot.org/uniprot/G3VID0 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9305:UST ^@ http://purl.uniprot.org/uniprot/A0A7N4PPT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane http://togogenome.org/gene/9305:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P859|||http://purl.uniprot.org/uniprot/A0A7N4P9U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/9305:PAXBP1 ^@ http://purl.uniprot.org/uniprot/G3W1S5 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9305:REM1 ^@ http://purl.uniprot.org/uniprot/G3WNH2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9305:ADCK5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NV28 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9305:EPYC ^@ http://purl.uniprot.org/uniprot/G3VIK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||extracellular matrix http://togogenome.org/gene/9305:PTS ^@ http://purl.uniprot.org/uniprot/A0A7N4PTE0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9305:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A7N4NJG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9305:LOC100916571 ^@ http://purl.uniprot.org/uniprot/G3VEY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100925039 ^@ http://purl.uniprot.org/uniprot/A0A7N4NL49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:COX3 ^@ http://purl.uniprot.org/uniprot/G1FKC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/9305:CMC1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9305:LOC100926318 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8I9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9305:RNMT ^@ http://purl.uniprot.org/uniprot/A0A7N4PMF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9305:BARHL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NI72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100925107 ^@ http://purl.uniprot.org/uniprot/G3WBT7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9305:MCL1 ^@ http://purl.uniprot.org/uniprot/G3WBC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||nucleoplasm http://togogenome.org/gene/9305:RPL4 ^@ http://purl.uniprot.org/uniprot/G3VHT1 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL4 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9305:HDHD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPZ2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9305:KCNA10 ^@ http://purl.uniprot.org/uniprot/G3VP89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:NIPA1 ^@ http://purl.uniprot.org/uniprot/G3W059 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9305:KRT35 ^@ http://purl.uniprot.org/uniprot/G3VR19 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:SERPINE1 ^@ http://purl.uniprot.org/uniprot/G3VRY9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:LOC100931606 ^@ http://purl.uniprot.org/uniprot/G3VXJ6|||http://purl.uniprot.org/uniprot/G3W3K3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. http://togogenome.org/gene/9305:PPP2CA ^@ http://purl.uniprot.org/uniprot/G3WVY5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9305:NSUN3 ^@ http://purl.uniprot.org/uniprot/G3VJ01 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9305:LOC100929577 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100924469 ^@ http://purl.uniprot.org/uniprot/G3VN27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100926076 ^@ http://purl.uniprot.org/uniprot/G3W241 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HSPA9 ^@ http://purl.uniprot.org/uniprot/G3WI07 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9305:NELFE ^@ http://purl.uniprot.org/uniprot/A0A7N4PGT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9305:BRIX1 ^@ http://purl.uniprot.org/uniprot/G3WB09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9305:LOC100916231 ^@ http://purl.uniprot.org/uniprot/G3WFN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SIX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1Z7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:STX16 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2Z2|||http://purl.uniprot.org/uniprot/G3WRF7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9305:LOC100923773 ^@ http://purl.uniprot.org/uniprot/G3W424 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9305:TENT5A ^@ http://purl.uniprot.org/uniprot/A0A7N4PWT2 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9305:HOXD1 ^@ http://purl.uniprot.org/uniprot/G3WUG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100935218 ^@ http://purl.uniprot.org/uniprot/G3VUV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CACNG1 ^@ http://purl.uniprot.org/uniprot/G3WGD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9305:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFS8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||Membrane|||caveola http://togogenome.org/gene/9305:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTL4 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9305:LOC100923259 ^@ http://purl.uniprot.org/uniprot/G3VLP6 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9305:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A7N4V2L8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9305:CENPBD1 ^@ http://purl.uniprot.org/uniprot/G3W5F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9305:PRKAB1 ^@ http://purl.uniprot.org/uniprot/G3X120 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9305:MKS1 ^@ http://purl.uniprot.org/uniprot/G3WG81 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9305:NCEH1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5B8 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9305:RIOK2 ^@ http://purl.uniprot.org/uniprot/G3VXT7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9305:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A7N4V240 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9305:DTD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/9305:CASS4 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9305:LOC100934169 ^@ http://purl.uniprot.org/uniprot/G3WNE3 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9305:LOC100934257 ^@ http://purl.uniprot.org/uniprot/G3WCC2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:LOC100934288 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYE1|||http://purl.uniprot.org/uniprot/G3WQ15 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:GPAT4 ^@ http://purl.uniprot.org/uniprot/G3WV51 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9305:ACTL7B ^@ http://purl.uniprot.org/uniprot/G3W6L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9305:FREM2 ^@ http://purl.uniprot.org/uniprot/G3VII7 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9305:LOC100926245 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CITED2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PST8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9305:BHMT ^@ http://purl.uniprot.org/uniprot/G3WPY2 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9305:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/G3WKJ9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9305:YAF2 ^@ http://purl.uniprot.org/uniprot/G3VYJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100930545 ^@ http://purl.uniprot.org/uniprot/G3VNY2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.|||Nucleus http://togogenome.org/gene/9305:AGPAT4 ^@ http://purl.uniprot.org/uniprot/G3VUK2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9305:LTB4R ^@ http://purl.uniprot.org/uniprot/A0A7N4PJM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TIGD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9305:BNIP1 ^@ http://purl.uniprot.org/uniprot/G3W0F4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZC4|||http://purl.uniprot.org/uniprot/G3WGI8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9305:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWJ5|||http://purl.uniprot.org/uniprot/A0A7N4UWZ4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9305:ALB ^@ http://purl.uniprot.org/uniprot/G3WQH5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:MAN2B2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJY6|||http://purl.uniprot.org/uniprot/G3VAF5 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9305:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/G3W8N5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:TAGLN3 ^@ http://purl.uniprot.org/uniprot/G3WU95 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9305:CERS3 ^@ http://purl.uniprot.org/uniprot/G3VHI1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9305:SLC50A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX37 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/9305:ASCC3 ^@ http://purl.uniprot.org/uniprot/G3WVG9 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/9305:DNTT ^@ http://purl.uniprot.org/uniprot/G3VQ55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9305:KREMEN2 ^@ http://purl.uniprot.org/uniprot/G3VDU6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:RGS8 ^@ http://purl.uniprot.org/uniprot/G3VU30 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nucleus|||Perikaryon|||dendrite http://togogenome.org/gene/9305:ELP5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:TSEN54 ^@ http://purl.uniprot.org/uniprot/G3X134 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/9305:LOC100916236 ^@ http://purl.uniprot.org/uniprot/G3VM25 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9305:LOC100916460 ^@ http://purl.uniprot.org/uniprot/G3W9C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9305:LAPTM4A ^@ http://purl.uniprot.org/uniprot/G3VWK7 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9305:LOC100927083 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9305:PHOX2A ^@ http://purl.uniprot.org/uniprot/G3VX50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SENP6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZ26|||http://purl.uniprot.org/uniprot/G3WDB4|||http://purl.uniprot.org/uniprot/G3WDB5 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9305:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9305:GPR34 ^@ http://purl.uniprot.org/uniprot/G3VFJ7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LOC100923548 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJK4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9305:MBOAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVX3|||http://purl.uniprot.org/uniprot/G3WVF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100922568 ^@ http://purl.uniprot.org/uniprot/G3W692 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:TREH ^@ http://purl.uniprot.org/uniprot/G3WE94 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/9305:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PS52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Interacts with SPTLC1.|||Membrane|||Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. http://togogenome.org/gene/9305:LOC100924731 ^@ http://purl.uniprot.org/uniprot/G3VUX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC100916307 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:QSOX1 ^@ http://purl.uniprot.org/uniprot/G3W7M3 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/9305:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1G0|||http://purl.uniprot.org/uniprot/G3VZY8 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Endoplasmic reticulum|||Membrane|||Secreted http://togogenome.org/gene/9305:SLC41A1 ^@ http://purl.uniprot.org/uniprot/G3WUF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9305:POLR2E ^@ http://purl.uniprot.org/uniprot/G3WAN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/9305:MGAT5 ^@ http://purl.uniprot.org/uniprot/G3WJ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9305:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYJ5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9305:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPH6|||http://purl.uniprot.org/uniprot/A0A7N4PXZ1|||http://purl.uniprot.org/uniprot/G3WY32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9305:VEZT ^@ http://purl.uniprot.org/uniprot/G3W1H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9305:SLC44A4 ^@ http://purl.uniprot.org/uniprot/G3W1J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9305:HNRNPA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYE2|||http://purl.uniprot.org/uniprot/A0A7N4PMM7|||http://purl.uniprot.org/uniprot/G3W829 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:SURF6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P933 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/9305:WDR12 ^@ http://purl.uniprot.org/uniprot/G3VXW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9305:KRT79 ^@ http://purl.uniprot.org/uniprot/G3VRH8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:SPDL1 ^@ http://purl.uniprot.org/uniprot/G3X0R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9305:INA ^@ http://purl.uniprot.org/uniprot/G3X1X5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:EIF5 ^@ http://purl.uniprot.org/uniprot/G3WXG2 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/9305:DDX11 ^@ http://purl.uniprot.org/uniprot/G3WNZ4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. http://togogenome.org/gene/9305:PPP3R1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q027 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/9305:LOC105749534 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGI9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9305:MCOLN2 ^@ http://purl.uniprot.org/uniprot/G3WTL6 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9305:PDCL ^@ http://purl.uniprot.org/uniprot/A0A7N4V0Y6 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9305:ADAM17 ^@ http://purl.uniprot.org/uniprot/G3VVV2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:POLR2G ^@ http://purl.uniprot.org/uniprot/G3VUQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||Nucleus http://togogenome.org/gene/9305:CPNE3 ^@ http://purl.uniprot.org/uniprot/G3VWY6 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9305:LOC100914775 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0F2 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9305:LOC100920628 ^@ http://purl.uniprot.org/uniprot/G3VFM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TXNRD3 ^@ http://purl.uniprot.org/uniprot/G3WF07 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/9305:EIF3H ^@ http://purl.uniprot.org/uniprot/G3WQD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9305:LOC100917721 ^@ http://purl.uniprot.org/uniprot/G3VDM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:KLHL36 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2N1|||http://purl.uniprot.org/uniprot/G3VRE7 ^@ Function ^@ Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9305:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/G3WCC6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9305:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1V0|||http://purl.uniprot.org/uniprot/G3WCI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9305:HAO1 ^@ http://purl.uniprot.org/uniprot/G3VF29 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9305:LOC100924766 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ74 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:ERGIC2 ^@ http://purl.uniprot.org/uniprot/G3VQR3|||http://purl.uniprot.org/uniprot/G3VQR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9305:SLC25A53 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIT8|||http://purl.uniprot.org/uniprot/G3WGT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9305:MYOC ^@ http://purl.uniprot.org/uniprot/G3WXB5 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion intermembrane space|||Mitochondrion outer membrane|||Rough endoplasmic reticulum|||cilium|||extracellular exosome|||extracellular matrix http://togogenome.org/gene/9305:LOC100927892 ^@ http://purl.uniprot.org/uniprot/G3VY59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HS3ST5 ^@ http://purl.uniprot.org/uniprot/G3WJQ9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:MRI1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ31|||http://purl.uniprot.org/uniprot/G3WDI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:TPRG1 ^@ http://purl.uniprot.org/uniprot/G3WCP6 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9305:RCAN1 ^@ http://purl.uniprot.org/uniprot/G3WV36|||http://purl.uniprot.org/uniprot/G3WV37 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9305:PSMB1 ^@ http://purl.uniprot.org/uniprot/G3WSZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:KIF18A ^@ http://purl.uniprot.org/uniprot/G3WSK3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:MMP2 ^@ http://purl.uniprot.org/uniprot/G3WFR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M10A family.|||Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.|||extracellular matrix http://togogenome.org/gene/9305:SLC41A3 ^@ http://purl.uniprot.org/uniprot/G3WAE9|||http://purl.uniprot.org/uniprot/G3WAF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9305:SMAGP ^@ http://purl.uniprot.org/uniprot/A0A7N4PEK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAGP family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9305:DRAM2 ^@ http://purl.uniprot.org/uniprot/G3WDA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PARPBP ^@ http://purl.uniprot.org/uniprot/G3VSR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:TMOD1 ^@ http://purl.uniprot.org/uniprot/G3WRK9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:LOC100915117 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZ80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SLC39A6 ^@ http://purl.uniprot.org/uniprot/G3WU64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:WNT7A ^@ http://purl.uniprot.org/uniprot/A0A7N4PN03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:LDHD ^@ http://purl.uniprot.org/uniprot/G3WBP4 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9305:UBA52 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSM3 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/9305:KIF2B ^@ http://purl.uniprot.org/uniprot/G3VZ52 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:MARCHF4 ^@ http://purl.uniprot.org/uniprot/G3WM13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100914986 ^@ http://purl.uniprot.org/uniprot/G5EA71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/9305:SEC24A ^@ http://purl.uniprot.org/uniprot/G3WPN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9305:TM4SF1 ^@ http://purl.uniprot.org/uniprot/G5EA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9305:KCNMB4 ^@ http://purl.uniprot.org/uniprot/G3VX28 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9305:OXTR ^@ http://purl.uniprot.org/uniprot/G3WCZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9305:LOC100916723 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100920855 ^@ http://purl.uniprot.org/uniprot/A0A7N4P713 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9305:SFXN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2V9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:LOC100927711 ^@ http://purl.uniprot.org/uniprot/G3WRN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9305:LOC100922045 ^@ http://purl.uniprot.org/uniprot/G3WY72 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9305:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPH8|||http://purl.uniprot.org/uniprot/G3WXQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9305:LOC100914552 ^@ http://purl.uniprot.org/uniprot/G3WTP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NDRG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMM3|||http://purl.uniprot.org/uniprot/G3WRD7 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9305:PIGP ^@ http://purl.uniprot.org/uniprot/G3WMY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9305:LOC100924880 ^@ http://purl.uniprot.org/uniprot/G3VV21 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9305:PDIA6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P346 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9305:GSC ^@ http://purl.uniprot.org/uniprot/A0A7N4P6F9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSJ3|||http://purl.uniprot.org/uniprot/G3WRE3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9305:GHSR ^@ http://purl.uniprot.org/uniprot/A0A7N4PWQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). http://togogenome.org/gene/9305:MFSD8 ^@ http://purl.uniprot.org/uniprot/G3WLV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF70|||http://purl.uniprot.org/uniprot/G3WAY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9305:DPYS ^@ http://purl.uniprot.org/uniprot/A0A7N4V2C4|||http://purl.uniprot.org/uniprot/G3WHL7 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/9305:LOC100921663 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5F3 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9305:C4H6orf120 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.|||Secreted http://togogenome.org/gene/9305:TMEM70 ^@ http://purl.uniprot.org/uniprot/G3W7W4 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9305:CALCB ^@ http://purl.uniprot.org/uniprot/A0A7N4V5T5 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9305:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3J3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:ABCG1 ^@ http://purl.uniprot.org/uniprot/G3WMN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9305:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A7N4NV51|||http://purl.uniprot.org/uniprot/G3W856 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9305:SLC16A13 ^@ http://purl.uniprot.org/uniprot/G3VC65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/G3WUF9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:CHRDL2 ^@ http://purl.uniprot.org/uniprot/G3W438 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:HOMEZ ^@ http://purl.uniprot.org/uniprot/A0A7N4V421|||http://purl.uniprot.org/uniprot/G3WPK3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A7N4P6S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:CMTM3 ^@ http://purl.uniprot.org/uniprot/G3VDH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PCNP ^@ http://purl.uniprot.org/uniprot/G3W3S0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/9305:OTP ^@ http://purl.uniprot.org/uniprot/G3X0Z0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100932338 ^@ http://purl.uniprot.org/uniprot/G3VN36 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9305:FAM83A ^@ http://purl.uniprot.org/uniprot/G3WI28 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9305:LOC100922691 ^@ http://purl.uniprot.org/uniprot/G3WLR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:SLC10A1 ^@ http://purl.uniprot.org/uniprot/G3VK42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9305:PFKFB3 ^@ http://purl.uniprot.org/uniprot/G3WJ62 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9305:GPNMB ^@ http://purl.uniprot.org/uniprot/G3W1A5 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9305:TK1 ^@ http://purl.uniprot.org/uniprot/G3X1C7 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9305:LPAR6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLE7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:IL26 ^@ http://purl.uniprot.org/uniprot/A0A7N4PH38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9305:STING1 ^@ http://purl.uniprot.org/uniprot/G3WCT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9305:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/9305:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJI3|||http://purl.uniprot.org/uniprot/G3WUD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9305:TMEM176A ^@ http://purl.uniprot.org/uniprot/A0A7N4P9P0 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9305:INHBC ^@ http://purl.uniprot.org/uniprot/G3VW78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9305:ACAT1 ^@ http://purl.uniprot.org/uniprot/G3WEN4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9305:LOC105751160 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0J5 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9305:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ64 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9305:C8A ^@ http://purl.uniprot.org/uniprot/G3VVQ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:OSMR ^@ http://purl.uniprot.org/uniprot/G3WEM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9305:LOC100933474 ^@ http://purl.uniprot.org/uniprot/G3W072 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9305:ALAS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NX02|||http://purl.uniprot.org/uniprot/G3W082 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A7N4P307 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9305:RAD50 ^@ http://purl.uniprot.org/uniprot/G3WB07 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9305:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9305:LOC100933335 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0Q6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MRPL44 ^@ http://purl.uniprot.org/uniprot/G3W7K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9305:RGS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V4D2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9305:YARS2 ^@ http://purl.uniprot.org/uniprot/G3VPN2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A7N4V3Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SGCA ^@ http://purl.uniprot.org/uniprot/G3WJL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||cytoskeleton http://togogenome.org/gene/9305:ALDH7A1 ^@ http://purl.uniprot.org/uniprot/G3WJ35 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9305:PARVB ^@ http://purl.uniprot.org/uniprot/A0A7N4P885 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||cytoskeleton http://togogenome.org/gene/9305:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/G3WSY8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:RPSA ^@ http://purl.uniprot.org/uniprot/G3VXP4 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9305:LOC100916977 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q095 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:TATDN1 ^@ http://purl.uniprot.org/uniprot/G3VY17 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9305:ADAM33 ^@ http://purl.uniprot.org/uniprot/G3WUH9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:AGT ^@ http://purl.uniprot.org/uniprot/G3WZF9|||http://purl.uniprot.org/uniprot/G3WZG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9305:MLF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P192 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9305:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/G3WUG1 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9305:CDNF ^@ http://purl.uniprot.org/uniprot/G3X224 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9305:PHAX ^@ http://purl.uniprot.org/uniprot/G3WIK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm http://togogenome.org/gene/9305:SLC35F2 ^@ http://purl.uniprot.org/uniprot/G3WIB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9305:INSRR ^@ http://purl.uniprot.org/uniprot/G3WV44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BATF ^@ http://purl.uniprot.org/uniprot/A0A7N4PD30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/9305:GSTK1 ^@ http://purl.uniprot.org/uniprot/G3VMY8 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9305:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.|||Nucleus http://togogenome.org/gene/9305:SPNS1 ^@ http://purl.uniprot.org/uniprot/G3WH45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9305:PCNX4 ^@ http://purl.uniprot.org/uniprot/G3WKU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9305:LOC100934191 ^@ http://purl.uniprot.org/uniprot/G3WM93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9305:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A7N4NY11|||http://purl.uniprot.org/uniprot/A0A7N4P880|||http://purl.uniprot.org/uniprot/G3WN96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9305:OSGEP ^@ http://purl.uniprot.org/uniprot/A0A7N4NLM5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:CHGB ^@ http://purl.uniprot.org/uniprot/G3WBP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9305:LOC100921373 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ATP5PF ^@ http://purl.uniprot.org/uniprot/G3WBY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9305:F9 ^@ http://purl.uniprot.org/uniprot/G3W4I8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:LOC100931911 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:HS2ST1 ^@ http://purl.uniprot.org/uniprot/G3VQJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane http://togogenome.org/gene/9305:LOC100914443 ^@ http://purl.uniprot.org/uniprot/G3WZF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9305:LOC100920676 ^@ http://purl.uniprot.org/uniprot/G3VEN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/G3WPQ5 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9305:KCNJ8 ^@ http://purl.uniprot.org/uniprot/G3WQR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9305:SAG ^@ http://purl.uniprot.org/uniprot/G3VMY5 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9305:IFT57 ^@ http://purl.uniprot.org/uniprot/G3WIG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9305:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVT3|||http://purl.uniprot.org/uniprot/G3WZI8 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9305:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3T7 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9305:IL18R1 ^@ http://purl.uniprot.org/uniprot/G3W1C1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9305:GAA ^@ http://purl.uniprot.org/uniprot/G3VVM7 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:ITK ^@ http://purl.uniprot.org/uniprot/G3WSK6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:LOC105749295 ^@ http://purl.uniprot.org/uniprot/G3X2D7|||http://purl.uniprot.org/uniprot/G3X2D8 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9305:LDHA ^@ http://purl.uniprot.org/uniprot/A0A7N4PK07|||http://purl.uniprot.org/uniprot/G3WT28 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9305:MGAT2 ^@ http://purl.uniprot.org/uniprot/G3VUH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:LOC100932136 ^@ http://purl.uniprot.org/uniprot/G3VR42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SLC29A1 ^@ http://purl.uniprot.org/uniprot/G3WYI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9305:RNF7 ^@ http://purl.uniprot.org/uniprot/G3WYG8 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9305:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSN1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:UBE4A ^@ http://purl.uniprot.org/uniprot/A0A7N4NLX9|||http://purl.uniprot.org/uniprot/G3WJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100931269 ^@ http://purl.uniprot.org/uniprot/G3WXV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:LOC100922209 ^@ http://purl.uniprot.org/uniprot/G3WH64 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:COL4A1 ^@ http://purl.uniprot.org/uniprot/G3WDT4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9305:INTS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUH7 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/9305:LOC100917088 ^@ http://purl.uniprot.org/uniprot/G3VQV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:FIGNL1 ^@ http://purl.uniprot.org/uniprot/G3WW32 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9305:PATL1 ^@ http://purl.uniprot.org/uniprot/G3VP14 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9305:LOC100918969 ^@ http://purl.uniprot.org/uniprot/G3VSD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXM2|||http://purl.uniprot.org/uniprot/G3WNC5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:BCAP31 ^@ http://purl.uniprot.org/uniprot/G3W549 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9305:TMEM14A ^@ http://purl.uniprot.org/uniprot/G3WQ40 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9305:LOC100925611 ^@ http://purl.uniprot.org/uniprot/G3WNF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9305:NCF2 ^@ http://purl.uniprot.org/uniprot/G3WJY7 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9305:ELAC1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q146 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9305:POLR3GL ^@ http://purl.uniprot.org/uniprot/A0A7N4PPB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9305:TSPAN12 ^@ http://purl.uniprot.org/uniprot/G3WFJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:DDX3X ^@ http://purl.uniprot.org/uniprot/G3W048 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9305:DUOX1 ^@ http://purl.uniprot.org/uniprot/G3WYX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9305:CHST10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A7N4V195|||http://purl.uniprot.org/uniprot/G3X3K1 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9305:LOC100919171 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:ETNPPL ^@ http://purl.uniprot.org/uniprot/G3VHJ6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9305:EIF3D ^@ http://purl.uniprot.org/uniprot/G3WCF6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9305:LOC100923025 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRW0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9305:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A7N4V1T8|||http://purl.uniprot.org/uniprot/G3X047 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9305:RHBG ^@ http://purl.uniprot.org/uniprot/A0A7N4PMQ1|||http://purl.uniprot.org/uniprot/G3WNR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9305:LOC100913730 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9305:ATF7IP ^@ http://purl.uniprot.org/uniprot/G3WYY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9305:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A7N4PWH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9305:TLL1 ^@ http://purl.uniprot.org/uniprot/G3W493 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100930860 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NDUFS8 ^@ http://purl.uniprot.org/uniprot/A0A7N4V4G4 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/9305:PRKG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIK1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9305:SCNN1B ^@ http://purl.uniprot.org/uniprot/G3W1E4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RBCK1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMQ0|||http://purl.uniprot.org/uniprot/G3VSL8 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9305:LOC100925613 ^@ http://purl.uniprot.org/uniprot/G3VWE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A7N4PCR2 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9305:LOC100919497 ^@ http://purl.uniprot.org/uniprot/G3WNK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100929658 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0I2|||http://purl.uniprot.org/uniprot/G3VSB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3A4|||http://purl.uniprot.org/uniprot/G3VFL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Mitochondrion inner membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/9305:UCMA ^@ http://purl.uniprot.org/uniprot/G3WQB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9305:RRAGD ^@ http://purl.uniprot.org/uniprot/G3WMR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9305:VWC2 ^@ http://purl.uniprot.org/uniprot/G3VW59 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9305:PLIN5 ^@ http://purl.uniprot.org/uniprot/G3VL52 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9305:BLK ^@ http://purl.uniprot.org/uniprot/G3WE04 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:RNF31 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFN3|||http://purl.uniprot.org/uniprot/G3VEA8 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9305:CCL21 ^@ http://purl.uniprot.org/uniprot/G3WY31 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:GSTA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMT7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9305:SMU1 ^@ http://purl.uniprot.org/uniprot/G3WGW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9305:MGRN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEJ5|||http://purl.uniprot.org/uniprot/G3W2V5|||http://purl.uniprot.org/uniprot/G3W2V6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9305:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXE5|||http://purl.uniprot.org/uniprot/G3WJR8 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9305:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/G3WRD3 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9305:TMC6 ^@ http://purl.uniprot.org/uniprot/G3X1M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9305:LOC100926333 ^@ http://purl.uniprot.org/uniprot/G3W241 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FABP1 ^@ http://purl.uniprot.org/uniprot/G3WAA6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9305:TAS2R1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9305:CSK ^@ http://purl.uniprot.org/uniprot/A0A7N4V2M7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:LOC100920457 ^@ http://purl.uniprot.org/uniprot/G3VBD0 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9305:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A7N4P206 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:AGA ^@ http://purl.uniprot.org/uniprot/G3VWM7 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9305:TXNIP ^@ http://purl.uniprot.org/uniprot/G3X2Y5 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9305:LOC100932522 ^@ http://purl.uniprot.org/uniprot/G3WJK7|||http://purl.uniprot.org/uniprot/G3WSM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9305:TP53INP2 ^@ http://purl.uniprot.org/uniprot/G3WZV8 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9305:TBR1 ^@ http://purl.uniprot.org/uniprot/G3WVW3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLY8 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9305:USP14 ^@ http://purl.uniprot.org/uniprot/G3WPF3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9305:MRPL41 ^@ http://purl.uniprot.org/uniprot/G3WAD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/9305:GLE1 ^@ http://purl.uniprot.org/uniprot/G3X3D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9305:RNASE12 ^@ http://purl.uniprot.org/uniprot/G3VEQ9 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9305:LOC100921482 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:BDKRB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V174 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9305:FAM3D ^@ http://purl.uniprot.org/uniprot/G3VKA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9305:TES ^@ http://purl.uniprot.org/uniprot/A0A7N4NYW6|||http://purl.uniprot.org/uniprot/G3WKX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||focal adhesion http://togogenome.org/gene/9305:MYF5 ^@ http://purl.uniprot.org/uniprot/G3WJV7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9305:CNKSR3 ^@ http://purl.uniprot.org/uniprot/G3VY28 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9305:ZWILCH ^@ http://purl.uniprot.org/uniprot/A0A7N4NYL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9305:C2H9orf78 ^@ http://purl.uniprot.org/uniprot/G3WG65 ^@ Similarity ^@ Belongs to the TLS1 family. http://togogenome.org/gene/9305:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPX5 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9305:LRP10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFD2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:NADK2 ^@ http://purl.uniprot.org/uniprot/G3VIN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Homodimer.|||Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.|||Mitochondrion http://togogenome.org/gene/9305:HSDL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSY3 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9305:HOMER2 ^@ http://purl.uniprot.org/uniprot/G3WZ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9305:RBM22 ^@ http://purl.uniprot.org/uniprot/G3WZQ9 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/9305:PTER ^@ http://purl.uniprot.org/uniprot/A0A7N4V3J6|||http://purl.uniprot.org/uniprot/G3VZ17 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LHFPL6 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ITGAX ^@ http://purl.uniprot.org/uniprot/G3VIX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:LOC100921723 ^@ http://purl.uniprot.org/uniprot/A0A7N4PD47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FABP7 ^@ http://purl.uniprot.org/uniprot/G3VLN6 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:CKMT1A ^@ http://purl.uniprot.org/uniprot/G3WMF9 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9305:RMI1 ^@ http://purl.uniprot.org/uniprot/G3WXI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9305:LOC100934670 ^@ http://purl.uniprot.org/uniprot/G3W2W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A7N4UXE2|||http://purl.uniprot.org/uniprot/G3WQL4 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9305:LOC100919277 ^@ http://purl.uniprot.org/uniprot/G3WSK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9305:ATP8 ^@ http://purl.uniprot.org/uniprot/G1FKC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9305:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLY2|||http://purl.uniprot.org/uniprot/G3VVI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9305:FAM174C ^@ http://purl.uniprot.org/uniprot/A0A7N4PEM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9305:IFITM5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYF9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9305:SGSH ^@ http://purl.uniprot.org/uniprot/G3VKR9 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9305:NEDD9 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIJ2|||http://purl.uniprot.org/uniprot/G3W026|||http://purl.uniprot.org/uniprot/G3W027 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9305:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A7N4NWQ1 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9305:DOK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGC6|||http://purl.uniprot.org/uniprot/G3WZM1 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9305:LOC100928736 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919393 ^@ http://purl.uniprot.org/uniprot/G3WEX2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9305:LOC100921468 ^@ http://purl.uniprot.org/uniprot/G3W064 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKJ8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9305:FABP9 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTI3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:LOC100933041 ^@ http://purl.uniprot.org/uniprot/G3VJP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Endoplasmic reticulum http://togogenome.org/gene/9305:BANP ^@ http://purl.uniprot.org/uniprot/G3VHZ1 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/9305:SPON1 ^@ http://purl.uniprot.org/uniprot/G3W1M1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9305:DIPK2B ^@ http://purl.uniprot.org/uniprot/G3WV56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9305:EXTL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PK72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:CD53 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEA5|||http://purl.uniprot.org/uniprot/G3WA72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:CALHM4 ^@ http://purl.uniprot.org/uniprot/G3VWK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9305:RPL7L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF84|||http://purl.uniprot.org/uniprot/G3WCG7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9305:LOC100920933 ^@ http://purl.uniprot.org/uniprot/G3W7Z8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BTK ^@ http://purl.uniprot.org/uniprot/G3WK98 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:OTULIN ^@ http://purl.uniprot.org/uniprot/G3WD99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9305:RPAP1 ^@ http://purl.uniprot.org/uniprot/G3WY13 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9305:TAGLN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQG6 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9305:TMEM175 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/9305:LOC100928795 ^@ http://purl.uniprot.org/uniprot/G3VQR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PTP4A3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGG7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9305:TOMM20 ^@ http://purl.uniprot.org/uniprot/A0A7N4V737 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:RNF20 ^@ http://purl.uniprot.org/uniprot/G3WDN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9305:TREX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PT14 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9305:CREBBP ^@ http://purl.uniprot.org/uniprot/G3WLJ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:MFAP3L ^@ http://purl.uniprot.org/uniprot/A0A7N4NRK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A7N4UYN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9305:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/G3WWY1 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9305:ZGPAT ^@ http://purl.uniprot.org/uniprot/A0A7N4PHV0|||http://purl.uniprot.org/uniprot/G3X020 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CHD4/Mi-2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9305:HSPB2 ^@ http://purl.uniprot.org/uniprot/G3WJW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9305:MYF6 ^@ http://purl.uniprot.org/uniprot/G3WJP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100922956 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9305:LOC100934627 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9305:LOC100931403 ^@ http://purl.uniprot.org/uniprot/G3VCJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100930365 ^@ http://purl.uniprot.org/uniprot/G3VMM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:JPH2 ^@ http://purl.uniprot.org/uniprot/G3VIV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9305:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9305:LPAR2 ^@ http://purl.uniprot.org/uniprot/G3WCQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GPR21 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8K2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:SNX30 ^@ http://purl.uniprot.org/uniprot/A0A7N4P684|||http://purl.uniprot.org/uniprot/G3W4J9 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9305:EPHB4 ^@ http://purl.uniprot.org/uniprot/G3W0Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:EXOSC2 ^@ http://purl.uniprot.org/uniprot/G3WU02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100915930 ^@ http://purl.uniprot.org/uniprot/G3W8C9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:PEX13 ^@ http://purl.uniprot.org/uniprot/G3WLZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-13 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9305:LOC100917623 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IFT122 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXB1 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/9305:DOCK2 ^@ http://purl.uniprot.org/uniprot/G3X0W7 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9305:FNTA ^@ http://purl.uniprot.org/uniprot/A0A7N4PRQ8|||http://purl.uniprot.org/uniprot/G3X2Q8 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9305:ITGA4 ^@ http://purl.uniprot.org/uniprot/G3WM33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:SATB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYS2|||http://purl.uniprot.org/uniprot/G3WBZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9305:TENT5D ^@ http://purl.uniprot.org/uniprot/A0A7N4PI35 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9305:NPC2 ^@ http://purl.uniprot.org/uniprot/G3X357 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/9305:UBR1 ^@ http://purl.uniprot.org/uniprot/G3W8M9 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9305:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY58 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/9305:LOC100918704 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZM4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:PDSS1 ^@ http://purl.uniprot.org/uniprot/G3WDJ1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9305:DUSP1 ^@ http://purl.uniprot.org/uniprot/G3VH35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9305:GMPR2 ^@ http://purl.uniprot.org/uniprot/G3VMX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9305:LOC100927334 ^@ http://purl.uniprot.org/uniprot/G3WGK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM98|||http://purl.uniprot.org/uniprot/G3WFM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9305:LOC100921329 ^@ http://purl.uniprot.org/uniprot/G3VY43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100926993 ^@ http://purl.uniprot.org/uniprot/G3W361 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100916019 ^@ http://purl.uniprot.org/uniprot/G3VYV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVU1|||http://purl.uniprot.org/uniprot/A0A7N4P6G4|||http://purl.uniprot.org/uniprot/G3W0J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:EDN1 ^@ http://purl.uniprot.org/uniprot/G3WQW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9305:HOXB9 ^@ http://purl.uniprot.org/uniprot/G3WHG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9305:RARRES2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZV4|||http://purl.uniprot.org/uniprot/G3W6Y7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:AGXT2 ^@ http://purl.uniprot.org/uniprot/G3W826 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9305:SF3B1 ^@ http://purl.uniprot.org/uniprot/G3WZ55|||http://purl.uniprot.org/uniprot/G3WZ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9305:SGO1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P134 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9305:HMCES ^@ http://purl.uniprot.org/uniprot/A0A7N4NTI8 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9305:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT33|||http://purl.uniprot.org/uniprot/A0A7N4PDG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9305:AASDHPPT ^@ http://purl.uniprot.org/uniprot/A0A7N4P0E7 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/9305:NELFCD ^@ http://purl.uniprot.org/uniprot/G3WJN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/9305:CLDN18 ^@ http://purl.uniprot.org/uniprot/G3VPH5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:LOC100924432 ^@ http://purl.uniprot.org/uniprot/G3WBG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1E7|||http://purl.uniprot.org/uniprot/G3WJN2 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/9305:RECQL5 ^@ http://purl.uniprot.org/uniprot/G3X0D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9305:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDH5 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9305:MANEA ^@ http://purl.uniprot.org/uniprot/G3W8H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:CLPS ^@ http://purl.uniprot.org/uniprot/A0A7N4NVC9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9305:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUA0 ^@ Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9305:RPL21 ^@ http://purl.uniprot.org/uniprot/G3VCP1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9305:MRAP2 ^@ http://purl.uniprot.org/uniprot/G3W7B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LOC100920353 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKL3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A7N4P8Y1|||http://purl.uniprot.org/uniprot/G3X197 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9305:ABCG5 ^@ http://purl.uniprot.org/uniprot/G3X3F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9305:LOC100931063 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GGACT ^@ http://purl.uniprot.org/uniprot/A0A7N4PIE7|||http://purl.uniprot.org/uniprot/G3WM55 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9305:CREB3L3 ^@ http://purl.uniprot.org/uniprot/G3W7T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2D5|||http://purl.uniprot.org/uniprot/A0A7N4V065 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9305:FAM76B ^@ http://purl.uniprot.org/uniprot/A0A7N4P2L0 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9305:CTH ^@ http://purl.uniprot.org/uniprot/G3WDG1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9305:LOC105750430 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CCDC47 ^@ http://purl.uniprot.org/uniprot/G3WHB6 ^@ Subcellular Location Annotation ^@ Membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9305:SMPD1 ^@ http://purl.uniprot.org/uniprot/G3VUX4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9305:SIX6 ^@ http://purl.uniprot.org/uniprot/G3WRH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Nucleus http://togogenome.org/gene/9305:SKP1 ^@ http://purl.uniprot.org/uniprot/G3WVY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9305:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9305:GREM2 ^@ http://purl.uniprot.org/uniprot/G3WF61 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:KCNJ13 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9305:REEP5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9305:MTMR9 ^@ http://purl.uniprot.org/uniprot/G3W443 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9305:IL15 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9305:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PH01 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9305:LOC100919888 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:C1H19orf53 ^@ http://purl.uniprot.org/uniprot/A0A7N4P470 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/9305:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9305:LOC100927424 ^@ http://purl.uniprot.org/uniprot/G3VU26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:VIPR1 ^@ http://purl.uniprot.org/uniprot/G3W7S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:BID ^@ http://purl.uniprot.org/uniprot/G3W5W1|||http://purl.uniprot.org/uniprot/G3W5W2 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.|||Induces caspases and apoptosis. Counters the protective effect of BCL2.|||Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9305:POLR3G ^@ http://purl.uniprot.org/uniprot/G3VWU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9305:CCT8L2 ^@ http://purl.uniprot.org/uniprot/G3WJ07 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/9305:DCT ^@ http://purl.uniprot.org/uniprot/G3WXQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9305:WNT8A ^@ http://purl.uniprot.org/uniprot/G3W8Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:MAP3K9 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLE3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9305:ARF6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PES5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9305:PKLR ^@ http://purl.uniprot.org/uniprot/A0A7N4P705 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9305:AQP9 ^@ http://purl.uniprot.org/uniprot/G3WD79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9305:TBCA ^@ http://purl.uniprot.org/uniprot/A0A7N4PYD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9305:GJB6 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:GEM ^@ http://purl.uniprot.org/uniprot/G3WWE5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9305:TMED6 ^@ http://purl.uniprot.org/uniprot/G3WKT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:CEMIP ^@ http://purl.uniprot.org/uniprot/G3W7K8 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9305:KCNMB3 ^@ http://purl.uniprot.org/uniprot/G3WVJ7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9305:GCNT3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS78 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:FGF20 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPK7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9305:PANX3 ^@ http://purl.uniprot.org/uniprot/G3WP76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9305:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9305:LOC100917272 ^@ http://purl.uniprot.org/uniprot/G3VPG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100916105 ^@ http://purl.uniprot.org/uniprot/G3VL01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MCM8 ^@ http://purl.uniprot.org/uniprot/G3WA38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9305:RECQL ^@ http://purl.uniprot.org/uniprot/G3WT75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100918335 ^@ http://purl.uniprot.org/uniprot/G3VXP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:COQ5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQZ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9305:SLC45A2 ^@ http://purl.uniprot.org/uniprot/G3VL33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC105749827 ^@ http://purl.uniprot.org/uniprot/G3VJ40 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9305:LOC100913862 ^@ http://purl.uniprot.org/uniprot/G3VYV5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9305:HSD17B11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUX4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:RPS15A ^@ http://purl.uniprot.org/uniprot/G3WY83 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit. http://togogenome.org/gene/9305:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A7N4PD36|||http://purl.uniprot.org/uniprot/G3WXL3|||http://purl.uniprot.org/uniprot/G3WXL4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9305:TBX18 ^@ http://purl.uniprot.org/uniprot/G3WB37 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:FFAR3 ^@ http://purl.uniprot.org/uniprot/G3VX91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9305:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:NDP ^@ http://purl.uniprot.org/uniprot/A0A7N4V2X2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:IFRD1 ^@ http://purl.uniprot.org/uniprot/G3WNB2|||http://purl.uniprot.org/uniprot/G3WNB3 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9305:TM6SF1 ^@ http://purl.uniprot.org/uniprot/G3X0R8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100914400 ^@ http://purl.uniprot.org/uniprot/G3WNG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9305:RPLP0 ^@ http://purl.uniprot.org/uniprot/G3VF68 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9305:LOC100922731 ^@ http://purl.uniprot.org/uniprot/G3VFG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CCNG1 ^@ http://purl.uniprot.org/uniprot/G3VZL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin G subfamily.|||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.|||Nucleus http://togogenome.org/gene/9305:PAH ^@ http://purl.uniprot.org/uniprot/G3WCK3 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9305:TMTC4 ^@ http://purl.uniprot.org/uniprot/G3WJV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9305:FRG1 ^@ http://purl.uniprot.org/uniprot/G3VUB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9305:LOC100933576 ^@ http://purl.uniprot.org/uniprot/G3X0E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9305:SCG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P442 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/9305:NGF ^@ http://purl.uniprot.org/uniprot/G3WIM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9305:TMCC1 ^@ http://purl.uniprot.org/uniprot/G3WPI2|||http://purl.uniprot.org/uniprot/G3WPI3 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9305:DCAF13 ^@ http://purl.uniprot.org/uniprot/G3VWM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/9305:LOC100932434 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGX2|||http://purl.uniprot.org/uniprot/G3WBF4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9305:HDAC8 ^@ http://purl.uniprot.org/uniprot/A0A7N4P686 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.|||Nucleus http://togogenome.org/gene/9305:GPER1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT72 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:PSMB4 ^@ http://purl.uniprot.org/uniprot/G3WPG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9305:LOC100917515 ^@ http://purl.uniprot.org/uniprot/G3WA97 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9305:LOC100918961 ^@ http://purl.uniprot.org/uniprot/G3WEY4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:LOC100932554 ^@ http://purl.uniprot.org/uniprot/G3WUM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100932401 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LIPG ^@ http://purl.uniprot.org/uniprot/G3VR16 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:LOC100928430 ^@ http://purl.uniprot.org/uniprot/G3VYL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9305:SLC6A2 ^@ http://purl.uniprot.org/uniprot/G3VJ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9305:AKAP8L ^@ http://purl.uniprot.org/uniprot/A0A7N4PVD6 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9305:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/G3W368 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:CD74 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGC7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:NIPAL4 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9305:MED1 ^@ http://purl.uniprot.org/uniprot/G3WTX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9305:MAPK7 ^@ http://purl.uniprot.org/uniprot/G3WKJ6 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9305:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9305:MRPL24 ^@ http://purl.uniprot.org/uniprot/G3WTU2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9305:KIFC2 ^@ http://purl.uniprot.org/uniprot/G3W3E0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:NT5E ^@ http://purl.uniprot.org/uniprot/G3WQS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9305:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0S3 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9305:CHI3L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYD4|||http://purl.uniprot.org/uniprot/G3WVU0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 18 family.|||Cytoplasm|||Endoplasmic reticulum|||Monomer.|||extracellular space http://togogenome.org/gene/9305:LOC100928142 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVT9|||http://purl.uniprot.org/uniprot/A0A7N4Q024|||http://purl.uniprot.org/uniprot/G3W8G1 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9305:SDC2 ^@ http://purl.uniprot.org/uniprot/G3W2N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9305:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A7N4P4T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9305:LOC100923890 ^@ http://purl.uniprot.org/uniprot/G3VAX9|||http://purl.uniprot.org/uniprot/G3VHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IZUMO3 ^@ http://purl.uniprot.org/uniprot/G3VCF5 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9305:PRPF19 ^@ http://purl.uniprot.org/uniprot/G3W6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9305:NPY4R2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UX36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9305:LOC100934436 ^@ http://purl.uniprot.org/uniprot/G3VHH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC105750795 ^@ http://purl.uniprot.org/uniprot/A0A7N4PG79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V856 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9305:TUBG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P414|||http://purl.uniprot.org/uniprot/G3WM03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9305:CELF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXF6|||http://purl.uniprot.org/uniprot/A0A7N4P2E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:TBXAS1 ^@ http://purl.uniprot.org/uniprot/G3WIP2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:STK17B ^@ http://purl.uniprot.org/uniprot/G3WPU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHM2 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9305:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/G3WMV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule|||filopodium|||lamellipodium http://togogenome.org/gene/9305:LOC100931380 ^@ http://purl.uniprot.org/uniprot/G3W8I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9305:POLR3C ^@ http://purl.uniprot.org/uniprot/G3X2N1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9305:OXSM ^@ http://purl.uniprot.org/uniprot/A0A7N4NHD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9305:LOC100927108 ^@ http://purl.uniprot.org/uniprot/G3VUQ6|||http://purl.uniprot.org/uniprot/G3VUQ7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9305:VEPH1 ^@ http://purl.uniprot.org/uniprot/G3X378|||http://purl.uniprot.org/uniprot/G3X379 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9305:GAPVD1 ^@ http://purl.uniprot.org/uniprot/G3W6Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9305:PDHA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCJ7|||http://purl.uniprot.org/uniprot/G3WRQ6 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9305:LPL ^@ http://purl.uniprot.org/uniprot/A0A7N4PZY2|||http://purl.uniprot.org/uniprot/G3W1U8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9305:NOXRED1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWJ5 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9305:LOC100929819 ^@ http://purl.uniprot.org/uniprot/G3W1I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/G3WPA6 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9305:TFIP11 ^@ http://purl.uniprot.org/uniprot/G3WMC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9305:GBF1 ^@ http://purl.uniprot.org/uniprot/G3X3M7 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9305:C4H17orf80 ^@ http://purl.uniprot.org/uniprot/G3WSY0|||http://purl.uniprot.org/uniprot/G3WSY2 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/9305:SPATA20 ^@ http://purl.uniprot.org/uniprot/G3VSI1 ^@ Function|||Subcellular Location Annotation ^@ May play a role in fertility regulation.|||Secreted http://togogenome.org/gene/9305:LOC100930838 ^@ http://purl.uniprot.org/uniprot/A0A7N4PU06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9305:LOC105750699 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0C0 ^@ Function|||Similarity ^@ Belongs to the calmodulin family.|||May be involved in calcium-mediated signal transduction. http://togogenome.org/gene/9305:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ52 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9305:SLC39A2 ^@ http://purl.uniprot.org/uniprot/G3VUM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PYCARD ^@ http://purl.uniprot.org/uniprot/G3VLS4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/9305:MRGPRF ^@ http://purl.uniprot.org/uniprot/A0A7N4P1R0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LOC100930272 ^@ http://purl.uniprot.org/uniprot/A0A7N4PY83 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/G3WB67 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9305:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/G3VKV2 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9305:LOC100916098 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EPHX1 ^@ http://purl.uniprot.org/uniprot/G3WKR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9305:LOC100928884 ^@ http://purl.uniprot.org/uniprot/G3WHN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NR4A2 ^@ http://purl.uniprot.org/uniprot/G3WIG9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9305:CPSF4 ^@ http://purl.uniprot.org/uniprot/G3WDI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9305:POLR2A ^@ http://purl.uniprot.org/uniprot/G3VJ85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9305:LOC100923986 ^@ http://purl.uniprot.org/uniprot/G3WD23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MCEE ^@ http://purl.uniprot.org/uniprot/A0A7N4P8J3 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9305:ING3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK03|||http://purl.uniprot.org/uniprot/G3WIR9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9305:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXE0|||http://purl.uniprot.org/uniprot/G3W4P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9305:GALNT5 ^@ http://purl.uniprot.org/uniprot/G3WVT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:KDM4C ^@ http://purl.uniprot.org/uniprot/G3W3L5 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/9305:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCA3|||http://purl.uniprot.org/uniprot/A0A7N4PSB4 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9305:GALM ^@ http://purl.uniprot.org/uniprot/G3WTZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/9305:MKX ^@ http://purl.uniprot.org/uniprot/A0A7N4P0B5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:RNF111 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDR6|||http://purl.uniprot.org/uniprot/G3WQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arkadia family.|||PML body http://togogenome.org/gene/9305:PSMG1 ^@ http://purl.uniprot.org/uniprot/G3W230 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits. http://togogenome.org/gene/9305:PARP10 ^@ http://purl.uniprot.org/uniprot/G3VI98 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9305:PPP1R35 ^@ http://purl.uniprot.org/uniprot/G3WAC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP1R35 family.|||centriole http://togogenome.org/gene/9305:LOC100925599 ^@ http://purl.uniprot.org/uniprot/G3VXT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9305:AREG ^@ http://purl.uniprot.org/uniprot/G3VV74 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:IRX2 ^@ http://purl.uniprot.org/uniprot/G3VFC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9305:PAQR5 ^@ http://purl.uniprot.org/uniprot/G3WNR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:KLHL40 ^@ http://purl.uniprot.org/uniprot/G3VZM8 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/9305:DAZL ^@ http://purl.uniprot.org/uniprot/A0A7N4PYW3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:LOC100913294 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9305:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRY5|||http://purl.uniprot.org/uniprot/G3WS12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:NCAPG ^@ http://purl.uniprot.org/uniprot/G3WU03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9305:BVES ^@ http://purl.uniprot.org/uniprot/G3WIZ0 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9305:XPO7 ^@ http://purl.uniprot.org/uniprot/G3X025 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:HOXD3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9305:ANKRD34A ^@ http://purl.uniprot.org/uniprot/G3X2W4 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9305:RDH10 ^@ http://purl.uniprot.org/uniprot/G3WMQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9305:FSHB ^@ http://purl.uniprot.org/uniprot/G3W6F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9305:MBTPS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHA5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9305:C6 ^@ http://purl.uniprot.org/uniprot/G3WFL6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:LOC105749564 ^@ http://purl.uniprot.org/uniprot/G3W0S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9305:PSMC2 ^@ http://purl.uniprot.org/uniprot/G3VN17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.|||Cytoplasm http://togogenome.org/gene/9305:DDR1 ^@ http://purl.uniprot.org/uniprot/G3W4S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100918237 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CFAP53 ^@ http://purl.uniprot.org/uniprot/G3W8G4 ^@ Similarity ^@ Belongs to the CFAP53 family. http://togogenome.org/gene/9305:LOC100916056 ^@ http://purl.uniprot.org/uniprot/G3VS82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9305:CPNE2 ^@ http://purl.uniprot.org/uniprot/G3WLA0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9305:CAPN9 ^@ http://purl.uniprot.org/uniprot/G3WZT3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9305:LOC100933193 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC100928536 ^@ http://purl.uniprot.org/uniprot/G3VGV3|||http://purl.uniprot.org/uniprot/G3VPF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MRPS18B ^@ http://purl.uniprot.org/uniprot/A0A7N4NGX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/9305:SLC11A1 ^@ http://purl.uniprot.org/uniprot/G3WUK2 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/9305:BBS2 ^@ http://purl.uniprot.org/uniprot/G3W852 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9305:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4J6|||http://purl.uniprot.org/uniprot/A0A7N4PJ76 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9305:NANOS3 ^@ http://purl.uniprot.org/uniprot/G3WFF1 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9305:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:LOC100917204 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ND3 ^@ http://purl.uniprot.org/uniprot/G1FKC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9305:DDIT3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPE2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9305:PLCD4 ^@ http://purl.uniprot.org/uniprot/G3WSY4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum|||Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.|||Nucleus http://togogenome.org/gene/9305:SLC35A4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9305:SCRN3 ^@ http://purl.uniprot.org/uniprot/G3WT68 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9305:MCM10 ^@ http://purl.uniprot.org/uniprot/G3WPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/9305:LOC100930293 ^@ http://purl.uniprot.org/uniprot/G3VHH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ORAI3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PD75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9305:ARAF ^@ http://purl.uniprot.org/uniprot/G3VVG4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9305:BTN1A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9305:SYS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9305:RPL35 ^@ http://purl.uniprot.org/uniprot/G3VQJ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9305:UIMC1 ^@ http://purl.uniprot.org/uniprot/G3WAW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9305:RALA ^@ http://purl.uniprot.org/uniprot/A0A7N4P3Q9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/9305:BEST2 ^@ http://purl.uniprot.org/uniprot/G3WSR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9305:NAB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V810|||http://purl.uniprot.org/uniprot/G3VVL8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9305:SLC39A10 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIJ4|||http://purl.uniprot.org/uniprot/G3WJ14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ENTR1 ^@ http://purl.uniprot.org/uniprot/G3VZU8 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/9305:TEKT2 ^@ http://purl.uniprot.org/uniprot/G3VSY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9305:IMP3 ^@ http://purl.uniprot.org/uniprot/G3VVD1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9305:LOC105749029 ^@ http://purl.uniprot.org/uniprot/G3WGK3 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:ARL14 ^@ http://purl.uniprot.org/uniprot/G3WWQ1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9305:NFKB1 ^@ http://purl.uniprot.org/uniprot/G3VZA9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:CPN1 ^@ http://purl.uniprot.org/uniprot/G3WAE7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9305:LOC100933134 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100926976 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRAME family. LRRC14 subfamily.|||Cytoplasm http://togogenome.org/gene/9305:POMT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9305:PRL ^@ http://purl.uniprot.org/uniprot/G3VMY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9305:PTK6 ^@ http://purl.uniprot.org/uniprot/G3X1S8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPT2|||http://purl.uniprot.org/uniprot/G3VYK5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9305:CASP14 ^@ http://purl.uniprot.org/uniprot/G3VXC0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9305:TMEM170A ^@ http://purl.uniprot.org/uniprot/A0A7N4PMH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9305:CKMT2 ^@ http://purl.uniprot.org/uniprot/G3WP31 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9305:FADS6 ^@ http://purl.uniprot.org/uniprot/G3X3G5 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/9305:COPB1 ^@ http://purl.uniprot.org/uniprot/G3WSR6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9305:LOC100914808 ^@ http://purl.uniprot.org/uniprot/A0A7N4PAX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PIR ^@ http://purl.uniprot.org/uniprot/G3VE48 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9305:RNF40 ^@ http://purl.uniprot.org/uniprot/G3W7I1|||http://purl.uniprot.org/uniprot/G3W7I2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9305:TMEM35A ^@ http://purl.uniprot.org/uniprot/G3WNH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane|||Vesicle http://togogenome.org/gene/9305:CAMK1G ^@ http://purl.uniprot.org/uniprot/A0A7N4NTS5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:LOC100933087 ^@ http://purl.uniprot.org/uniprot/G3WC35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MGAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKK3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/9305:CFAP300 ^@ http://purl.uniprot.org/uniprot/A0A7N4NV09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9305:HIGD2A ^@ http://purl.uniprot.org/uniprot/A0A7N4NVA0 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9305:EGFL8 ^@ http://purl.uniprot.org/uniprot/G3W9E1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:CRABP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5A7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:COX2 ^@ http://purl.uniprot.org/uniprot/G1FKC1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:BARX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PDCD11 ^@ http://purl.uniprot.org/uniprot/G3X1K0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:NOL6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||nucleolus http://togogenome.org/gene/9305:PUS10 ^@ http://purl.uniprot.org/uniprot/G3WMA9 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9305:TAC3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXY8|||http://purl.uniprot.org/uniprot/G3VRE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9305:SLC1A1 ^@ http://purl.uniprot.org/uniprot/G3WGD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9305:SLC5A12 ^@ http://purl.uniprot.org/uniprot/G3W6P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9305:HMX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UX19 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PIK3CG ^@ http://purl.uniprot.org/uniprot/G3W321 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9305:SEC16B ^@ http://purl.uniprot.org/uniprot/G3WKS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9305:LOC100917324 ^@ http://purl.uniprot.org/uniprot/G3VZI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ETV6 ^@ http://purl.uniprot.org/uniprot/G3WQ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:PRIM1 ^@ http://purl.uniprot.org/uniprot/G3VKA9 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9305:LOC100914459 ^@ http://purl.uniprot.org/uniprot/G3WSL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100921191 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6C7 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9305:ENPP3 ^@ http://purl.uniprot.org/uniprot/G3W316 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9305:OAZ3 ^@ http://purl.uniprot.org/uniprot/G3WTA5 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9305:AGRP ^@ http://purl.uniprot.org/uniprot/A0A7N4V5E0|||http://purl.uniprot.org/uniprot/G3WKU1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKB7|||http://purl.uniprot.org/uniprot/G3WCB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9305:LOC100921193 ^@ http://purl.uniprot.org/uniprot/G3VUH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RAD21 ^@ http://purl.uniprot.org/uniprot/G3WSK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9305:LOC100929914 ^@ http://purl.uniprot.org/uniprot/G3WJ40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXQ0|||http://purl.uniprot.org/uniprot/G3W8Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9305:RFC5 ^@ http://purl.uniprot.org/uniprot/G3WLM1 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9305:WLS ^@ http://purl.uniprot.org/uniprot/A0A7N4PIX4|||http://purl.uniprot.org/uniprot/G3WY74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:DGKA ^@ http://purl.uniprot.org/uniprot/G3W1Q3|||http://purl.uniprot.org/uniprot/G3W1Q4 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9305:RPAIN ^@ http://purl.uniprot.org/uniprot/G3VGY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SNRPA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0C1|||http://purl.uniprot.org/uniprot/G3VVW4 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9305:STK11 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6K2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/9305:SPX ^@ http://purl.uniprot.org/uniprot/A0A7N4PL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/9305:HPCAL4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQA4 ^@ Function ^@ May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. http://togogenome.org/gene/9305:CTSZ ^@ http://purl.uniprot.org/uniprot/A0A7N4NU27|||http://purl.uniprot.org/uniprot/G3WJH4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Belongs to the peptidase C1 family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9305:LOC100930845 ^@ http://purl.uniprot.org/uniprot/A0A7N4P221 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:EPB42 ^@ http://purl.uniprot.org/uniprot/G3WE12 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/9305:LOC100922206 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8R7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:DNAAF4 ^@ http://purl.uniprot.org/uniprot/G3W7J6 ^@ Subcellular Location Annotation ^@ Dynein axonemal particle|||neuron projection http://togogenome.org/gene/9305:UPP2 ^@ http://purl.uniprot.org/uniprot/G3X0L6 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9305:C9 ^@ http://purl.uniprot.org/uniprot/G3W3E7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted|||Target cell membrane http://togogenome.org/gene/9305:TAS2R40 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9305:LOC100923460 ^@ http://purl.uniprot.org/uniprot/G3WCG3|||http://purl.uniprot.org/uniprot/G3WCQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:POU4F3 ^@ http://purl.uniprot.org/uniprot/G3W1P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9305:TIGD7 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100914686 ^@ http://purl.uniprot.org/uniprot/G3W2X3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9305:APEX1 ^@ http://purl.uniprot.org/uniprot/G3WKB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9305:POLH ^@ http://purl.uniprot.org/uniprot/G3WPK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100931087 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100918012 ^@ http://purl.uniprot.org/uniprot/A0A7N4NW04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/G3WB12 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9305:LOC100928538 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CLIC6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PB55 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9305:BCHE ^@ http://purl.uniprot.org/uniprot/G3WUZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9305:HOXB13 ^@ http://purl.uniprot.org/uniprot/G3WJ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9305:CIT ^@ http://purl.uniprot.org/uniprot/G3X145 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9305:SLC6A1 ^@ http://purl.uniprot.org/uniprot/G3X151 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9305:GGT6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PG22 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9305:LOC100924346 ^@ http://purl.uniprot.org/uniprot/G3W5X9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9305:PROZ ^@ http://purl.uniprot.org/uniprot/G3WX86 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:KRT18 ^@ http://purl.uniprot.org/uniprot/G3VTP8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:POP7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9305:CAVIN1 ^@ http://purl.uniprot.org/uniprot/G3WP13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9305:SOX8 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A7N4P0K4 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9305:RTF2 ^@ http://purl.uniprot.org/uniprot/G3WFW7 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9305:SLFN11 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM05 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9305:FGD5 ^@ http://purl.uniprot.org/uniprot/G3WV35 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:TGS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3M7|||http://purl.uniprot.org/uniprot/G3WI36 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/9305:LOC100931214 ^@ http://purl.uniprot.org/uniprot/A0A7N4V631 ^@ Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9305:FBLN7 ^@ http://purl.uniprot.org/uniprot/G3WTK0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LHPP ^@ http://purl.uniprot.org/uniprot/G3VTT2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9305:CHMP5 ^@ http://purl.uniprot.org/uniprot/G3W969 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9305:LOC100914388 ^@ http://purl.uniprot.org/uniprot/G3VF83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A7N4PYD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9305:MTERF3 ^@ http://purl.uniprot.org/uniprot/G3VRF2 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9305:PIGC ^@ http://purl.uniprot.org/uniprot/A0A7N4NUQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9305:PCSK6 ^@ http://purl.uniprot.org/uniprot/G3VXH5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9305:GATB ^@ http://purl.uniprot.org/uniprot/G3WE99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9305:PMS2 ^@ http://purl.uniprot.org/uniprot/G3WLR8 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9305:ANKRD34C ^@ http://purl.uniprot.org/uniprot/A0A7N4PA72 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9305:EIF3E ^@ http://purl.uniprot.org/uniprot/G3WJ02 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||Nucleus|||PML body|||Phosphorylated upon DNA damage, probably by ATM or ATR. http://togogenome.org/gene/9305:MPI ^@ http://purl.uniprot.org/uniprot/A0A7N4PNY7|||http://purl.uniprot.org/uniprot/G3WTA6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9305:AQP4 ^@ http://purl.uniprot.org/uniprot/G3WQD1|||http://purl.uniprot.org/uniprot/G3WQD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9305:GOT1 ^@ http://purl.uniprot.org/uniprot/G3WLZ6 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9305:FREM1 ^@ http://purl.uniprot.org/uniprot/G3WYA2 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9305:SULT4A1 ^@ http://purl.uniprot.org/uniprot/G3VPT7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:RNF121 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RPL8 ^@ http://purl.uniprot.org/uniprot/G3WKH0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9305:SPI1 ^@ http://purl.uniprot.org/uniprot/G3WY81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:LOC100919354 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1P0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:NUP62 ^@ http://purl.uniprot.org/uniprot/G3VGJ2 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/9305:NR0B2 ^@ http://purl.uniprot.org/uniprot/G3WN78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:MOGAT3 ^@ http://purl.uniprot.org/uniprot/G3VHW0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100915707 ^@ http://purl.uniprot.org/uniprot/G3WFD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GART ^@ http://purl.uniprot.org/uniprot/G3W376 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9305:DNAJB14 ^@ http://purl.uniprot.org/uniprot/G3VUI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:COQ6 ^@ http://purl.uniprot.org/uniprot/G3VLC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/9305:BORCS7 ^@ http://purl.uniprot.org/uniprot/G3X2X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Membrane http://togogenome.org/gene/9305:NCK1 ^@ http://purl.uniprot.org/uniprot/G3VW66 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9305:LOC100921728 ^@ http://purl.uniprot.org/uniprot/G3W1T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LTBP2 ^@ http://purl.uniprot.org/uniprot/G3X2N7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9305:SPAG7 ^@ http://purl.uniprot.org/uniprot/G3VUS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9305:F11R ^@ http://purl.uniprot.org/uniprot/G3WTT4|||http://purl.uniprot.org/uniprot/G3WTT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9305:PJVK ^@ http://purl.uniprot.org/uniprot/G3W8J0 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9305:UCN ^@ http://purl.uniprot.org/uniprot/G3WJB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9305:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4C8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:NAPG ^@ http://purl.uniprot.org/uniprot/G3WLN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9305:PMS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7U9|||http://purl.uniprot.org/uniprot/G3WIS0 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9305:DES ^@ http://purl.uniprot.org/uniprot/G3WHB8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/G3WQN1 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9305:CALHM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NU79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9305:SNRPG ^@ http://purl.uniprot.org/uniprot/G3WGG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9305:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNV9 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9305:TUSC3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXF2|||http://purl.uniprot.org/uniprot/G3WTN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/G3VSZ0 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9305:WSCD2 ^@ http://purl.uniprot.org/uniprot/G3WH65 ^@ Similarity ^@ Belongs to the WSCD family. http://togogenome.org/gene/9305:LOC100928060 ^@ http://purl.uniprot.org/uniprot/G3W942 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Involved in actively transporting phosphate into cells via Na(+) cotransport.|||Membrane http://togogenome.org/gene/9305:LAMP3 ^@ http://purl.uniprot.org/uniprot/G3WUM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9305:COCH ^@ http://purl.uniprot.org/uniprot/G3WM71 ^@ Function ^@ Plays a role in the control of cell shape and motility in the trabecular meshwork. http://togogenome.org/gene/9305:ASIC1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100913731 ^@ http://purl.uniprot.org/uniprot/G3WR56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBA2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9305:UCK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHG8 ^@ Similarity|||Subunit ^@ Belongs to the uridine kinase family.|||Homotetramer. http://togogenome.org/gene/9305:METTL8 ^@ http://purl.uniprot.org/uniprot/G3WLY8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9305:LOC100930974 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX98 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:ANAPC15 ^@ http://purl.uniprot.org/uniprot/G3VII4 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9305:TMX2 ^@ http://purl.uniprot.org/uniprot/G3WT70 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:IL18RAP ^@ http://purl.uniprot.org/uniprot/G3VG70 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9305:THNSL1 ^@ http://purl.uniprot.org/uniprot/G3WWT9 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9305:EVC ^@ http://purl.uniprot.org/uniprot/G3WQS6 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/9305:LOC100913939 ^@ http://purl.uniprot.org/uniprot/G3WEZ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A7N4NZR4|||http://purl.uniprot.org/uniprot/G3X0Y9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9305:LOC100925523 ^@ http://purl.uniprot.org/uniprot/G3VK77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100927203 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRA9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:LOC100917068 ^@ http://purl.uniprot.org/uniprot/G3VF03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC105750685 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYZ1 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9305:CTSH ^@ http://purl.uniprot.org/uniprot/A0A7N4PI91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9305:NPHS2 ^@ http://purl.uniprot.org/uniprot/G3VVV0 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9305:ADD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9A4 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9305:GABRB1 ^@ http://purl.uniprot.org/uniprot/G3VV14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:LOC100920416 ^@ http://purl.uniprot.org/uniprot/G3W6Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:EEF2 ^@ http://purl.uniprot.org/uniprot/G3VZU6 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/9305:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/G3VX45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:HMGCR ^@ http://purl.uniprot.org/uniprot/G3VNK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9305:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9305:ENO4 ^@ http://purl.uniprot.org/uniprot/G3WYH3 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/9305:SKA3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9305:TXLNB ^@ http://purl.uniprot.org/uniprot/G3VMC8 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9305:TASOR2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PES4 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9305:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9305:NOC3L ^@ http://purl.uniprot.org/uniprot/A0A7N4NGB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/9305:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q153 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heparin-binding growth factors family.|||Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.|||Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.|||Secreted http://togogenome.org/gene/9305:CCN4 ^@ http://purl.uniprot.org/uniprot/G3WQU8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:POLA1 ^@ http://purl.uniprot.org/uniprot/G3WJA6 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/9305:LOC100922607 ^@ http://purl.uniprot.org/uniprot/G3WMN8 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9305:SPA17 ^@ http://purl.uniprot.org/uniprot/G3WPY4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9305:EXOC2 ^@ http://purl.uniprot.org/uniprot/G3VEK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9305:MRPS5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX94 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9305:SFXN4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUP8|||http://purl.uniprot.org/uniprot/G3WNZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9305:LOC100934230 ^@ http://purl.uniprot.org/uniprot/G3WMB8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:BMP4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDK2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:FAM131B ^@ http://purl.uniprot.org/uniprot/A0A7N4P498 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9305:RNASE10 ^@ http://purl.uniprot.org/uniprot/G3VKR6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9305:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSC8|||http://purl.uniprot.org/uniprot/A0A7N4V7E5 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9305:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V464 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9305:LOC100919283 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ENKD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7K5|||http://purl.uniprot.org/uniprot/G3VRK7 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9305:GNGT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9305:TACR3 ^@ http://purl.uniprot.org/uniprot/G3VD07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ERCC3 ^@ http://purl.uniprot.org/uniprot/G3VZG5 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/9305:HTR1D ^@ http://purl.uniprot.org/uniprot/A0A7N4P594 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9305:NMNAT1 ^@ http://purl.uniprot.org/uniprot/G3W9B6 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9305:DCST2 ^@ http://purl.uniprot.org/uniprot/G3VSF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ENO2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3Q1|||http://purl.uniprot.org/uniprot/G3WUN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100917935 ^@ http://purl.uniprot.org/uniprot/A0A7N4PST4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FAM161B ^@ http://purl.uniprot.org/uniprot/G3VMX1 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9305:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NG55|||http://purl.uniprot.org/uniprot/G3W0L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9305:LOC100924004 ^@ http://purl.uniprot.org/uniprot/G3X0E0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:NIPAL2 ^@ http://purl.uniprot.org/uniprot/G3VNB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9305:LOC100932237 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HTRA4 ^@ http://purl.uniprot.org/uniprot/G3X2G8 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9305:LOC100918920 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CCDC172 ^@ http://purl.uniprot.org/uniprot/G3VA37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9305:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0B1|||http://purl.uniprot.org/uniprot/G3VV03 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:FGD3 ^@ http://purl.uniprot.org/uniprot/G3WXE9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:SLC39A5 ^@ http://purl.uniprot.org/uniprot/G3VH54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MINAR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWY2|||http://purl.uniprot.org/uniprot/G3VE22 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9305:LOC100925942 ^@ http://purl.uniprot.org/uniprot/G3VJL7 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9305:PYCR2 ^@ http://purl.uniprot.org/uniprot/G3WN62 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9305:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBC7 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9305:LOC100915753 ^@ http://purl.uniprot.org/uniprot/G3VFC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P650|||http://purl.uniprot.org/uniprot/G3VRT7 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9305:NOG ^@ http://purl.uniprot.org/uniprot/A0A7N4NWG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/9305:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYR2 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9305:RCAN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXJ6 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9305:LOC100927849 ^@ http://purl.uniprot.org/uniprot/G3WGY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GUCY2D ^@ http://purl.uniprot.org/uniprot/G3WLS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9305:LOC100924758 ^@ http://purl.uniprot.org/uniprot/G3VEZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NEU1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBU0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9305:PSMB7 ^@ http://purl.uniprot.org/uniprot/G3WU12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. http://togogenome.org/gene/9305:FAM110C ^@ http://purl.uniprot.org/uniprot/A0A7N4V5P5 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9305:LOC100917407 ^@ http://purl.uniprot.org/uniprot/G3W0T0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:SHOC2 ^@ http://purl.uniprot.org/uniprot/G3WBX1 ^@ Function|||Similarity ^@ Belongs to the SHOC2 family.|||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. http://togogenome.org/gene/9305:TYRP1 ^@ http://purl.uniprot.org/uniprot/G3VZQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9305:ZFPL1 ^@ http://purl.uniprot.org/uniprot/G3VGE2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/9305:LGI3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1W3|||http://purl.uniprot.org/uniprot/G3X116 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXJ5 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9305:EXO1 ^@ http://purl.uniprot.org/uniprot/G3W8T9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/9305:TLX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100921941 ^@ http://purl.uniprot.org/uniprot/G3VUD7 ^@ Caution|||Similarity ^@ Belongs to the FXYD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100918326 ^@ http://purl.uniprot.org/uniprot/G3W9C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TOR4A ^@ http://purl.uniprot.org/uniprot/A0A7N4NSZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Membrane http://togogenome.org/gene/9305:F2R ^@ http://purl.uniprot.org/uniprot/G3W599 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ATAD1 ^@ http://purl.uniprot.org/uniprot/G3VTP7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9305:TIMM44 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:CCDC153 ^@ http://purl.uniprot.org/uniprot/G3W503 ^@ Similarity ^@ Belongs to the UPF0610 family. http://togogenome.org/gene/9305:MRPL33 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUY1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9305:GCM1 ^@ http://purl.uniprot.org/uniprot/G3WTH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100923003 ^@ http://purl.uniprot.org/uniprot/G3VKC5 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9305:SEMA3F ^@ http://purl.uniprot.org/uniprot/G3X247|||http://purl.uniprot.org/uniprot/G3X248 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:SERPINF1 ^@ http://purl.uniprot.org/uniprot/G3VZE9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:LOC100916836 ^@ http://purl.uniprot.org/uniprot/G3WB26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9305:LOC100934578 ^@ http://purl.uniprot.org/uniprot/G3VVM9 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9305:PTPA ^@ http://purl.uniprot.org/uniprot/G3VB41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9305:RPL26 ^@ http://purl.uniprot.org/uniprot/G3WCU1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9305:LOC100928906 ^@ http://purl.uniprot.org/uniprot/G3VGC5 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9305:LOC100928229 ^@ http://purl.uniprot.org/uniprot/G3VSW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:KRT7 ^@ http://purl.uniprot.org/uniprot/G3WL72 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:LOC100919827 ^@ http://purl.uniprot.org/uniprot/G3W7W1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9305:GABBR1 ^@ http://purl.uniprot.org/uniprot/G3VPG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SFTPC ^@ http://purl.uniprot.org/uniprot/G3X147 ^@ Function|||Subcellular Location Annotation ^@ Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.|||surface film http://togogenome.org/gene/9305:ST3GAL4 ^@ http://purl.uniprot.org/uniprot/G3VC60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:DAO ^@ http://purl.uniprot.org/uniprot/G3WF43 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/9305:PFDN1 ^@ http://purl.uniprot.org/uniprot/G3WS10 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/9305:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A7N4PY72 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9305:SNAP25 ^@ http://purl.uniprot.org/uniprot/G3VSV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9305:GPR25 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3Z4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:HOPX ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ATP10B ^@ http://purl.uniprot.org/uniprot/A0A7N4PR68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9305:LOC100932138 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FLVCR2 ^@ http://purl.uniprot.org/uniprot/G3WWV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/G3VTN1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9305:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A7N4P4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MYOD1 ^@ http://purl.uniprot.org/uniprot/G3WXZ9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9305:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A7N4P707 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9305:PDCL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PG10 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9305:LOC100925080 ^@ http://purl.uniprot.org/uniprot/A0A7N4NU63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:NDNF ^@ http://purl.uniprot.org/uniprot/G3W1T7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:C2H9orf116 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPP2 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9305:NDUFS7 ^@ http://purl.uniprot.org/uniprot/G3WLN5 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/9305:FAM149B1 ^@ http://purl.uniprot.org/uniprot/G3VKS0 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9305:GPN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7U9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9305:LOC100918458 ^@ http://purl.uniprot.org/uniprot/G3VXY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100924360 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLI6|||http://purl.uniprot.org/uniprot/G3WFA5 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9305:CFAP97D2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ61 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9305:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P467|||http://purl.uniprot.org/uniprot/A0A7N4V731 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9305:STK40 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHM4|||http://purl.uniprot.org/uniprot/G3X0L0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/9305:TMEM254 ^@ http://purl.uniprot.org/uniprot/G3VUF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:AQP3 ^@ http://purl.uniprot.org/uniprot/G3VKB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NIM1K ^@ http://purl.uniprot.org/uniprot/G3WBK1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:CBLIF ^@ http://purl.uniprot.org/uniprot/A0A7N4PCH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9305:CDX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC105750241 ^@ http://purl.uniprot.org/uniprot/G3WY07 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9305:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKG8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9305:HIBCH ^@ http://purl.uniprot.org/uniprot/G3WP61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/9305:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NG49 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9305:JAG2 ^@ http://purl.uniprot.org/uniprot/G3VAT1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9305:TOX4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NW66|||http://purl.uniprot.org/uniprot/G3W4A0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:NETO1 ^@ http://purl.uniprot.org/uniprot/G3VFF1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:NLE1 ^@ http://purl.uniprot.org/uniprot/G3VN49 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:LMX1A ^@ http://purl.uniprot.org/uniprot/G3WNU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:NGFR ^@ http://purl.uniprot.org/uniprot/G3VV93 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100927938 ^@ http://purl.uniprot.org/uniprot/G3VYM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A7N4PQW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9305:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKR0 ^@ Subcellular Location Annotation|||Subunit ^@ Component of the nexin-dynein regulatory complex (N-DRC).|||flagellum axoneme http://togogenome.org/gene/9305:DIPK1C ^@ http://purl.uniprot.org/uniprot/G3W4A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:HPGD ^@ http://purl.uniprot.org/uniprot/G3W470 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:LOC100916478 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:LOC100914095 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PL24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9305:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNE9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9305:MC4R ^@ http://purl.uniprot.org/uniprot/G3VTY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9305:SPATA6L ^@ http://purl.uniprot.org/uniprot/G3WIC2 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9305:POLR2M ^@ http://purl.uniprot.org/uniprot/G3WLU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/9305:LOC100919403 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9305:POLE ^@ http://purl.uniprot.org/uniprot/G3W6W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/9305:FAM136A ^@ http://purl.uniprot.org/uniprot/G3WG72 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/9305:PYROXD1 ^@ http://purl.uniprot.org/uniprot/G3WTG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9305:ARSF ^@ http://purl.uniprot.org/uniprot/G3W030 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9305:ELOC ^@ http://purl.uniprot.org/uniprot/G3W849 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9305:NRN1L ^@ http://purl.uniprot.org/uniprot/A0A7N4P348 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9305:LEPROTL1 ^@ http://purl.uniprot.org/uniprot/G3WEN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9305:LOC100920499 ^@ http://purl.uniprot.org/uniprot/G3WZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9305:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVR8|||http://purl.uniprot.org/uniprot/G3WVC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9305:VCAN ^@ http://purl.uniprot.org/uniprot/G3VZ56 ^@ Caution|||Similarity ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:DRC7 ^@ http://purl.uniprot.org/uniprot/G3VWX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/9305:ARAP3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1X3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:MSH5 ^@ http://purl.uniprot.org/uniprot/G3VWQ2 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9305:SDC4 ^@ http://purl.uniprot.org/uniprot/G3WKH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9305:RARS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1A1|||http://purl.uniprot.org/uniprot/G3WRU8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPW4|||http://purl.uniprot.org/uniprot/G3WBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:LOC100915226 ^@ http://purl.uniprot.org/uniprot/G3WPS0|||http://purl.uniprot.org/uniprot/G3WPS1 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9305:DICER1 ^@ http://purl.uniprot.org/uniprot/G3WFC6 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/9305:SPPL2B ^@ http://purl.uniprot.org/uniprot/G3VS63|||http://purl.uniprot.org/uniprot/G3VS64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9305:GALC ^@ http://purl.uniprot.org/uniprot/G3VEU4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/9305:DDC ^@ http://purl.uniprot.org/uniprot/G3WV06 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9305:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDL1|||http://purl.uniprot.org/uniprot/G3VZU0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucagon family.|||Interacts with ADCYAP1R1 (via N-terminal extracellular domain).|||Secreted http://togogenome.org/gene/9305:TRIM54 ^@ http://purl.uniprot.org/uniprot/G3WIP5 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/9305:F12 ^@ http://purl.uniprot.org/uniprot/G3WPF1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:SMARCA2 ^@ http://purl.uniprot.org/uniprot/G3W0Z6|||http://purl.uniprot.org/uniprot/G3W0Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9305:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9305:TERF2IP ^@ http://purl.uniprot.org/uniprot/G3VIQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9305:LOC100914875 ^@ http://purl.uniprot.org/uniprot/G3VEJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A7N4NI24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9305:SLC17A8 ^@ http://purl.uniprot.org/uniprot/G3WDI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100916503 ^@ http://purl.uniprot.org/uniprot/G3VFG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/9305:SLC44A2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJJ1|||http://purl.uniprot.org/uniprot/G3VP50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9305:SERPINI2 ^@ http://purl.uniprot.org/uniprot/G3W2E9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:LOC100929496 ^@ http://purl.uniprot.org/uniprot/A0A7N4P994 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:SLC18A2 ^@ http://purl.uniprot.org/uniprot/G3WVI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9305:GDAP1L1 ^@ http://purl.uniprot.org/uniprot/G3VSU6 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/9305:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PY36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane|||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. http://togogenome.org/gene/9305:IAH1 ^@ http://purl.uniprot.org/uniprot/G3VXB7 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9305:C1H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q137 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/9305:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9305:LOC100935068 ^@ http://purl.uniprot.org/uniprot/A0A076G1J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9305:C3AR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9305:WASF2 ^@ http://purl.uniprot.org/uniprot/G3VQY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9305:TEF ^@ http://purl.uniprot.org/uniprot/A0A7N4P9I4|||http://purl.uniprot.org/uniprot/G3W605 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100915113 ^@ http://purl.uniprot.org/uniprot/G3VY30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDI2|||http://purl.uniprot.org/uniprot/G3WTS3 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9305:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9305:OGDH ^@ http://purl.uniprot.org/uniprot/A0A7N4NTG9|||http://purl.uniprot.org/uniprot/A0A7N4PJA4|||http://purl.uniprot.org/uniprot/G3WW88 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9305:KCNB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NII8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon http://togogenome.org/gene/9305:PRMT7 ^@ http://purl.uniprot.org/uniprot/G3VT19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/9305:MEAF6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFQ7|||http://purl.uniprot.org/uniprot/G3WES0|||http://purl.uniprot.org/uniprot/G3WES1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/9305:LETMD1 ^@ http://purl.uniprot.org/uniprot/G3VIF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CALR ^@ http://purl.uniprot.org/uniprot/A0A7N4PYZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen|||Monomer. http://togogenome.org/gene/9305:CAPN7 ^@ http://purl.uniprot.org/uniprot/G3VKK8 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9305:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PK04|||http://purl.uniprot.org/uniprot/G3X2J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9305:CWC15 ^@ http://purl.uniprot.org/uniprot/G3WVL5 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9305:ISL1 ^@ http://purl.uniprot.org/uniprot/G3WAC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100930173 ^@ http://purl.uniprot.org/uniprot/G3WJN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ORC5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJ88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:CHRNA7 ^@ http://purl.uniprot.org/uniprot/G3WE61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:LOC100930819 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CLDN7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLS7|||http://purl.uniprot.org/uniprot/G3W1I6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:PITX1 ^@ http://purl.uniprot.org/uniprot/G3WK78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9305:MDFI ^@ http://purl.uniprot.org/uniprot/G3W329 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9305:UBA7 ^@ http://purl.uniprot.org/uniprot/G3X040 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9305:LOC100933622 ^@ http://purl.uniprot.org/uniprot/G3WNM9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PIGF ^@ http://purl.uniprot.org/uniprot/G3W9U0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LOC100922680 ^@ http://purl.uniprot.org/uniprot/G3VZ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SHC1 ^@ http://purl.uniprot.org/uniprot/G3VPR5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVS3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9305:DACT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY91 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/9305:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100916119 ^@ http://purl.uniprot.org/uniprot/G3VEY5 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9305:HBZ ^@ http://purl.uniprot.org/uniprot/A0A7N4PK19|||http://purl.uniprot.org/uniprot/G3WDN9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9305:PDGFRA ^@ http://purl.uniprot.org/uniprot/A0A7N4NXR5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9305:STX1B ^@ http://purl.uniprot.org/uniprot/A0A7N4V672 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/9305:MGAT5B ^@ http://purl.uniprot.org/uniprot/G3VDS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:CLPTM1L ^@ http://purl.uniprot.org/uniprot/A0A7N4NPP1|||http://purl.uniprot.org/uniprot/G3WU60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9305:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/G3WQ65 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:LOC100929747 ^@ http://purl.uniprot.org/uniprot/G3VVD9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:LOC100917092 ^@ http://purl.uniprot.org/uniprot/G3VC51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKV0|||http://purl.uniprot.org/uniprot/G3VM85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:LOC100934869 ^@ http://purl.uniprot.org/uniprot/A0A7N4PC09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100922418 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACVR1 ^@ http://purl.uniprot.org/uniprot/G3WYP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9305:RPL29 ^@ http://purl.uniprot.org/uniprot/G3VXJ3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9305:LOC100913541 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MOGAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PH48|||http://purl.uniprot.org/uniprot/G3WSI8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:MED18 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9305:KCNA4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.|||Cell membrane|||Membrane|||axon http://togogenome.org/gene/9305:LOC100930076 ^@ http://purl.uniprot.org/uniprot/G3VX84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ICAM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9305:XPA ^@ http://purl.uniprot.org/uniprot/G3WTQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9305:CD36 ^@ http://purl.uniprot.org/uniprot/G3W326 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the CD36 family.|||Cell membrane|||Golgi apparatus|||Membrane|||Membrane raft http://togogenome.org/gene/9305:HMGB3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9305:MANEAL ^@ http://purl.uniprot.org/uniprot/G3WLP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:FUCA2 ^@ http://purl.uniprot.org/uniprot/G3WL20 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9305:TSPAN7 ^@ http://purl.uniprot.org/uniprot/G3WHB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:LHX3 ^@ http://purl.uniprot.org/uniprot/G3WDD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:MSANTD3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSQ2 ^@ Similarity ^@ Belongs to the MSANTD3 family. http://togogenome.org/gene/9305:BMP10 ^@ http://purl.uniprot.org/uniprot/G3W835 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:TUBB6 ^@ http://purl.uniprot.org/uniprot/G3VXT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9305:LRRC8A ^@ http://purl.uniprot.org/uniprot/G3X3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919063 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZE8|||http://purl.uniprot.org/uniprot/G3WSP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:EML4 ^@ http://purl.uniprot.org/uniprot/G3WFN5 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9305:ACKR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9305:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NI06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9305:IK ^@ http://purl.uniprot.org/uniprot/G3WV90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9305:TGM1 ^@ http://purl.uniprot.org/uniprot/G3VPQ0 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9305:PBX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC100931906 ^@ http://purl.uniprot.org/uniprot/G3W997 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:DYNLT3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZL1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9305:ATG7 ^@ http://purl.uniprot.org/uniprot/G3X2I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9305:LEPR ^@ http://purl.uniprot.org/uniprot/G3WA33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9305:RPL36 ^@ http://purl.uniprot.org/uniprot/G3WK82 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9305:EIF3M ^@ http://purl.uniprot.org/uniprot/G3WZE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9305:SGTA ^@ http://purl.uniprot.org/uniprot/G3WEQ9 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9305:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/G3VW05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9305:FZD6 ^@ http://purl.uniprot.org/uniprot/G3VPF7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:BCKDK ^@ http://purl.uniprot.org/uniprot/G3WE42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9305:LOC100935147 ^@ http://purl.uniprot.org/uniprot/G3VBV2 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC100915997 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSU1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:CHIT1 ^@ http://purl.uniprot.org/uniprot/G3WWC7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9305:CSTF1 ^@ http://purl.uniprot.org/uniprot/G3WIW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SLITRK6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NU28 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9305:LOC100921839 ^@ http://purl.uniprot.org/uniprot/G3W844 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9305:TAGLN ^@ http://purl.uniprot.org/uniprot/G3WC56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calponin family.|||Cytoplasm http://togogenome.org/gene/9305:RAB14 ^@ http://purl.uniprot.org/uniprot/G3WZY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9305:PHC3 ^@ http://purl.uniprot.org/uniprot/G3WRG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:NSUN6 ^@ http://purl.uniprot.org/uniprot/G3W2F4 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:RRP1B ^@ http://purl.uniprot.org/uniprot/G3WZX4 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9305:LOC100921717 ^@ http://purl.uniprot.org/uniprot/G3W0U7 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/9305:ENTPD1 ^@ http://purl.uniprot.org/uniprot/G3W8B3 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9305:ST14 ^@ http://purl.uniprot.org/uniprot/G3W452 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100920805 ^@ http://purl.uniprot.org/uniprot/G3W397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HSPA13 ^@ http://purl.uniprot.org/uniprot/G3VJF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9305:DDX6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ88|||http://purl.uniprot.org/uniprot/G3WD54 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9305:LARS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVK2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:IL21 ^@ http://purl.uniprot.org/uniprot/A0A7N4PK96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9305:F7 ^@ http://purl.uniprot.org/uniprot/G3WY11 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/G3X2C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:LOC100930214 ^@ http://purl.uniprot.org/uniprot/G3W6R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LAPTM5 ^@ http://purl.uniprot.org/uniprot/G3WJE8 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9305:EPN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0K6|||http://purl.uniprot.org/uniprot/G3VQA4 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9305:LOC100924990 ^@ http://purl.uniprot.org/uniprot/G3VVW9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:NDUFS5 ^@ http://purl.uniprot.org/uniprot/G3WYW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9305:ND5 ^@ http://purl.uniprot.org/uniprot/J9S3Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:KCNJ11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9305:KCNV1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PAT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/9305:GPRC5B ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ94 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:ACSM5 ^@ http://purl.uniprot.org/uniprot/G3X3T1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9305:GUCA2B ^@ http://purl.uniprot.org/uniprot/G3WEU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9305:CLDN17 ^@ http://purl.uniprot.org/uniprot/G3WHJ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:PRKAR2A ^@ http://purl.uniprot.org/uniprot/A0A7N4NNT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:XRCC6 ^@ http://purl.uniprot.org/uniprot/G3WB04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9305:SLC40A1 ^@ http://purl.uniprot.org/uniprot/G3WCX4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/9305:PLSCR5 ^@ http://purl.uniprot.org/uniprot/G3WXE2 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9305:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9305:ADGRG1 ^@ http://purl.uniprot.org/uniprot/G3VRU6|||http://purl.uniprot.org/uniprot/G3VRU7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9305:TECR ^@ http://purl.uniprot.org/uniprot/G3VD97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:DDO ^@ http://purl.uniprot.org/uniprot/G3VH80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9305:OPLAH ^@ http://purl.uniprot.org/uniprot/G3VND4 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/9305:CIBAR2 ^@ http://purl.uniprot.org/uniprot/G3WBY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9305:UFL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMC6 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/9305:ADA ^@ http://purl.uniprot.org/uniprot/G3W4S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9305:MMP27 ^@ http://purl.uniprot.org/uniprot/G3WLF4 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9305:MRPS15 ^@ http://purl.uniprot.org/uniprot/G3X124 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9305:MARCO ^@ http://purl.uniprot.org/uniprot/G3WYB9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:HESX1 ^@ http://purl.uniprot.org/uniprot/G3WGR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC100918178 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSI5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9305:LOC100929669 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFS4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LOC100923293 ^@ http://purl.uniprot.org/uniprot/G3WET9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PRNP ^@ http://purl.uniprot.org/uniprot/A0A7N4NL04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Golgi apparatus|||Membrane http://togogenome.org/gene/9305:LOC100916072 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2R4|||http://purl.uniprot.org/uniprot/G3WEH4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:FAM83C ^@ http://purl.uniprot.org/uniprot/G3X1V8|||http://purl.uniprot.org/uniprot/G3X1W9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAM83 family.|||Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-210 and Ser-211 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9305:DNAJC2 ^@ http://purl.uniprot.org/uniprot/G3VI89 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9305:HEBP2 ^@ http://purl.uniprot.org/uniprot/G3VA21 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9305:LOC100935408 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919095 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HMGB2 ^@ http://purl.uniprot.org/uniprot/G3WGP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9305:ISOC1 ^@ http://purl.uniprot.org/uniprot/G3VGN2 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9305:TOP1MT ^@ http://purl.uniprot.org/uniprot/A0A7N4PGC9|||http://purl.uniprot.org/uniprot/A0A7N4UXW5 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9305:UPK1A ^@ http://purl.uniprot.org/uniprot/G3VZ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:LOC100926077 ^@ http://purl.uniprot.org/uniprot/G3WEL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7Y0 ^@ Function ^@ Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. http://togogenome.org/gene/9305:LOC100919138 ^@ http://purl.uniprot.org/uniprot/G3VDB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/G3WBS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:SERPINE2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V656 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4E9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9305:ERCC4 ^@ http://purl.uniprot.org/uniprot/G3WDR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9305:MAL ^@ http://purl.uniprot.org/uniprot/G3WJI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RNF170 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMP2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0X5 ^@ Similarity ^@ Belongs to the GrpE family. http://togogenome.org/gene/9305:FBXO32 ^@ http://purl.uniprot.org/uniprot/G3WN58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TMEM184C ^@ http://purl.uniprot.org/uniprot/G3VRW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GLOD4 ^@ http://purl.uniprot.org/uniprot/G3WE18 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/9305:C1S ^@ http://purl.uniprot.org/uniprot/G3WVK6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PKMYT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEN0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:DUOXA1 ^@ http://purl.uniprot.org/uniprot/G3WYU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9305:CD27 ^@ http://purl.uniprot.org/uniprot/G3WPJ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100930678 ^@ http://purl.uniprot.org/uniprot/G3VFQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:FABP6 ^@ http://purl.uniprot.org/uniprot/G3W244 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:GUF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/9305:NIF3L1 ^@ http://purl.uniprot.org/uniprot/G3WHH7 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/9305:SEC16A ^@ http://purl.uniprot.org/uniprot/A0A7N4PYB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9305:PDXK ^@ http://purl.uniprot.org/uniprot/G3X091 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/9305:PNPLA7 ^@ http://purl.uniprot.org/uniprot/A0A7N4P624 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:GPR20 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY53 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:OLFM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UX22|||http://purl.uniprot.org/uniprot/G3WZT5 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9305:AXIN2 ^@ http://purl.uniprot.org/uniprot/G3VT89 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:PAQR6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8W3|||http://purl.uniprot.org/uniprot/G3WMC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:LOC105749391 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CAMK1D ^@ http://purl.uniprot.org/uniprot/A0A7N4PL52 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:SHFL ^@ http://purl.uniprot.org/uniprot/G3W6B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHFL family.|||Nucleus|||P-body http://togogenome.org/gene/9305:EPHA4 ^@ http://purl.uniprot.org/uniprot/G3WZW2 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9305:NUP107 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6D1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9305:LAMP2 ^@ http://purl.uniprot.org/uniprot/G3WBL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9305:SEMA3B ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ77 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:DOCK10 ^@ http://purl.uniprot.org/uniprot/G3X2A3|||http://purl.uniprot.org/uniprot/G3X2A4 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9305:AASS ^@ http://purl.uniprot.org/uniprot/G3WY37 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9305:DMRT2 ^@ http://purl.uniprot.org/uniprot/G3W5W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9305:LOC105750145 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYB0 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9305:NFIL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.|||Belongs to the bZIP family. NFIL3 subfamily.|||Homodimer. Binds DNA as a dimer.|||Nucleus http://togogenome.org/gene/9305:XDH ^@ http://purl.uniprot.org/uniprot/G3WL03 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Homodimer. Interacts with BTN1A1.|||Peroxisome http://togogenome.org/gene/9305:MID1 ^@ http://purl.uniprot.org/uniprot/G3WM73 ^@ Function|||Subcellular Location Annotation ^@ Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.|||cytoskeleton http://togogenome.org/gene/9305:CD3E ^@ http://purl.uniprot.org/uniprot/G3WKI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ADCY9 ^@ http://purl.uniprot.org/uniprot/G3WH44 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9305:UBXN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF03|||http://purl.uniprot.org/uniprot/G3VR25 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:CORO1A ^@ http://purl.uniprot.org/uniprot/A0A7N4NYU0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9305:HEATR1 ^@ http://purl.uniprot.org/uniprot/G3W120 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9305:LOC100920300 ^@ http://purl.uniprot.org/uniprot/G3VD59 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:LOC100926596 ^@ http://purl.uniprot.org/uniprot/G3W2I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PREB ^@ http://purl.uniprot.org/uniprot/A0A7N4P275|||http://purl.uniprot.org/uniprot/G3WGF9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9305:G6PC3 ^@ http://purl.uniprot.org/uniprot/G3WQH7|||http://purl.uniprot.org/uniprot/G3WQH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NV76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A7N4PY64|||http://purl.uniprot.org/uniprot/G3WNW4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9305:LOC100916020 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100934317 ^@ http://purl.uniprot.org/uniprot/G3VWD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/9305:GRIN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9305:SAHAI-12 ^@ http://purl.uniprot.org/uniprot/B3F368 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9305:CNIH4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9305:PRDM1 ^@ http://purl.uniprot.org/uniprot/G3W8I5|||http://purl.uniprot.org/uniprot/G3W8I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9305:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A7N4PHN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9305:NR2E1 ^@ http://purl.uniprot.org/uniprot/G3X050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:NR5A2 ^@ http://purl.uniprot.org/uniprot/G3WD27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9305:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/G3VWI2 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9305:SFMBT1 ^@ http://purl.uniprot.org/uniprot/G3VNX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMP1|||http://purl.uniprot.org/uniprot/A0A7N4V627|||http://purl.uniprot.org/uniprot/G3WGF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ITGA2B ^@ http://purl.uniprot.org/uniprot/G3WU27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:LOC100922237 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:XPC ^@ http://purl.uniprot.org/uniprot/G3VDT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9305:LOC100923479 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CSAD ^@ http://purl.uniprot.org/uniprot/G3VEQ4 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9305:PARG ^@ http://purl.uniprot.org/uniprot/G3VT35 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/9305:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1D6 ^@ Subcellular Location Annotation ^@ autophagosome http://togogenome.org/gene/9305:LRRC8E ^@ http://purl.uniprot.org/uniprot/A0A7N4PR96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC105751019 ^@ http://purl.uniprot.org/uniprot/G3VRN5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9305:APOA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ23 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9305:HR ^@ http://purl.uniprot.org/uniprot/A0A7N4V860|||http://purl.uniprot.org/uniprot/G3X0V2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:RAB32 ^@ http://purl.uniprot.org/uniprot/G3W0Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9305:WNT9A ^@ http://purl.uniprot.org/uniprot/G3WH52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:BFSP1 ^@ http://purl.uniprot.org/uniprot/G3W818 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/9305:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PC33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ATP4B ^@ http://purl.uniprot.org/uniprot/G3WQQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9305:PGAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9305:MRPL51 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHY1 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family. http://togogenome.org/gene/9305:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A7N4V038 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9305:CCNK ^@ http://purl.uniprot.org/uniprot/G3VQZ0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9305:MC3R ^@ http://purl.uniprot.org/uniprot/A0A7N4P8A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9305:RAB38 ^@ http://purl.uniprot.org/uniprot/G3VG12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9305:MLLT11 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/9305:GCG ^@ http://purl.uniprot.org/uniprot/G3WZV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9305:NPR1 ^@ http://purl.uniprot.org/uniprot/G3W938 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9305:KCNJ10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9305:USE1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PD91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:TBC1D24 ^@ http://purl.uniprot.org/uniprot/G3WNG7 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse|||Synapse http://togogenome.org/gene/9305:MYOG ^@ http://purl.uniprot.org/uniprot/G3WUV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:EXTL1 ^@ http://purl.uniprot.org/uniprot/G3W0D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:ATP8B1 ^@ http://purl.uniprot.org/uniprot/G3WZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9305:CD14 ^@ http://purl.uniprot.org/uniprot/G3WV43 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9305:TMED9 ^@ http://purl.uniprot.org/uniprot/G3WQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:PARP3 ^@ http://purl.uniprot.org/uniprot/G3VZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9305:PPP1R10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBM5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9305:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJ02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:SCRN2 ^@ http://purl.uniprot.org/uniprot/G3VMJ1 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9305:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM75 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:EXOC3 ^@ http://purl.uniprot.org/uniprot/G3X2Z6 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9305:LIMS2 ^@ http://purl.uniprot.org/uniprot/G3VV48 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9305:ZC3H12A ^@ http://purl.uniprot.org/uniprot/A0A7N4UXW6 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9305:PPIE ^@ http://purl.uniprot.org/uniprot/A0A7N4V6D6|||http://purl.uniprot.org/uniprot/G3X115 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9305:PARP6 ^@ http://purl.uniprot.org/uniprot/G3W7W9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9305:EFHC1 ^@ http://purl.uniprot.org/uniprot/G3WKQ8 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9305:GSX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NL71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PPDPF ^@ http://purl.uniprot.org/uniprot/G3X1U9 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9305:LOC100927686 ^@ http://purl.uniprot.org/uniprot/G3VV47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:DPM3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P357 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/9305:LOC100915444 ^@ http://purl.uniprot.org/uniprot/G3WF68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RNF112 ^@ http://purl.uniprot.org/uniprot/G3WLF8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9305:ADAMTS5 ^@ http://purl.uniprot.org/uniprot/G3WI56 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9305:SPSB4 ^@ http://purl.uniprot.org/uniprot/G3X144 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9305:TSN ^@ http://purl.uniprot.org/uniprot/G3WE39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9305:SIGIRR ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ39|||http://purl.uniprot.org/uniprot/G3VYY0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9305:DARS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNB3|||http://purl.uniprot.org/uniprot/G3VVB2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9305:KRT4 ^@ http://purl.uniprot.org/uniprot/G3VTL1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM01 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9305:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7D2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family.|||Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. http://togogenome.org/gene/9305:RACK1 ^@ http://purl.uniprot.org/uniprot/G3WI55 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/9305:SLC6A17 ^@ http://purl.uniprot.org/uniprot/G3W453 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9305:LOC100934611 ^@ http://purl.uniprot.org/uniprot/G3VL91 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9305:SPTB ^@ http://purl.uniprot.org/uniprot/A0A7N4P7T0 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9305:B3GAT3 ^@ http://purl.uniprot.org/uniprot/G3VNI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:GPATCH1 ^@ http://purl.uniprot.org/uniprot/G3WTW2 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/9305:KRT17 ^@ http://purl.uniprot.org/uniprot/G3VXT1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:LAMP5 ^@ http://purl.uniprot.org/uniprot/G3WH95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9305:MYO1G ^@ http://purl.uniprot.org/uniprot/G3VGW6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9305:LOC100932549 ^@ http://purl.uniprot.org/uniprot/G3WPN0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:MBD4 ^@ http://purl.uniprot.org/uniprot/G3WID2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with MLH1.|||Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.|||Nucleus http://togogenome.org/gene/9305:CLN8 ^@ http://purl.uniprot.org/uniprot/G3WZ61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BBS4 ^@ http://purl.uniprot.org/uniprot/G3WV05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS4 family.|||Membrane|||centrosome|||cilium membrane http://togogenome.org/gene/9305:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4Q3|||http://purl.uniprot.org/uniprot/G3VUD5 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9305:SLC39A1 ^@ http://purl.uniprot.org/uniprot/G3WE50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PPP1R16B ^@ http://purl.uniprot.org/uniprot/A0A7N4NIR5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:TAC1 ^@ http://purl.uniprot.org/uniprot/G3W054 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9305:SIM1 ^@ http://purl.uniprot.org/uniprot/G3WUK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:EPGN ^@ http://purl.uniprot.org/uniprot/G3WW74 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100934526 ^@ http://purl.uniprot.org/uniprot/G3VXJ6|||http://purl.uniprot.org/uniprot/G3W3K3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. http://togogenome.org/gene/9305:PLA2G4F ^@ http://purl.uniprot.org/uniprot/G3VNT3 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9305:LOC100931131 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9305:AQP11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9305:XYLB ^@ http://purl.uniprot.org/uniprot/G3WAV7 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/9305:SAHAI-01 ^@ http://purl.uniprot.org/uniprot/B3F356 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9305:RAP2C ^@ http://purl.uniprot.org/uniprot/A0A7N4V7D5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9305:LOC100934370 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRP6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:RBM48 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGC8|||http://purl.uniprot.org/uniprot/G3X3W1 ^@ Similarity ^@ Belongs to the RBM48 family. http://togogenome.org/gene/9305:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/A0A7N4PFL1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9305:ADPRH ^@ http://purl.uniprot.org/uniprot/G3VH32 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9305:WDFY2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYD6 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9305:MDGA1 ^@ http://purl.uniprot.org/uniprot/G3WWI0|||http://purl.uniprot.org/uniprot/G3WWI1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:GAL3ST2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN91|||http://purl.uniprot.org/uniprot/G3WTL1 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9305:LTN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P540 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/9305:EFNA1 ^@ http://purl.uniprot.org/uniprot/G3VY37 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:PRPF4 ^@ http://purl.uniprot.org/uniprot/G3WZG5 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9305:C1H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMU4|||http://purl.uniprot.org/uniprot/G3WSA8 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9305:NSMCE1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKL3|||http://purl.uniprot.org/uniprot/A0A7N4V878 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9305:MTAP ^@ http://purl.uniprot.org/uniprot/G3VJ26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9305:NNT ^@ http://purl.uniprot.org/uniprot/G3W0Q2 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9305:LOC100919364 ^@ http://purl.uniprot.org/uniprot/G3VF43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EIF2D ^@ http://purl.uniprot.org/uniprot/A0A7N4PB58 ^@ Similarity ^@ Belongs to the eIF2D family. http://togogenome.org/gene/9305:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A7N4PZP7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9305:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGM1 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9305:LOC100916021 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPV7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:ACTL9 ^@ http://purl.uniprot.org/uniprot/A0A7N4NX06 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:ABRAXAS2 ^@ http://purl.uniprot.org/uniprot/G3VFI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0U4 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9305:SCPEP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P6I3|||http://purl.uniprot.org/uniprot/G3VPW3 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9305:ENTPD2 ^@ http://purl.uniprot.org/uniprot/G3W8C0 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9305:LOC100934825 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:NTS ^@ http://purl.uniprot.org/uniprot/A0A7N4PVE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9305:NXPH3 ^@ http://purl.uniprot.org/uniprot/G3W0B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9305:LOC100927121 ^@ http://purl.uniprot.org/uniprot/G3VUU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100926475 ^@ http://purl.uniprot.org/uniprot/A0A7N4PU01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ZNF277 ^@ http://purl.uniprot.org/uniprot/G3WJD3 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/9305:LPAR1 ^@ http://purl.uniprot.org/uniprot/G3VT67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9305:PAQR3 ^@ http://purl.uniprot.org/uniprot/G3VX60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:HAAO ^@ http://purl.uniprot.org/uniprot/G3W5N0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9305:MMP13 ^@ http://purl.uniprot.org/uniprot/G3WPX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.|||Secreted http://togogenome.org/gene/9305:LIM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P368 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/9305:ECHDC1 ^@ http://purl.uniprot.org/uniprot/G3X2Z7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9305:PRPH ^@ http://purl.uniprot.org/uniprot/G3VSD9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:KCNE2 ^@ http://purl.uniprot.org/uniprot/G3VF67 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9305:STT3A ^@ http://purl.uniprot.org/uniprot/G3WYH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9305:PMP22 ^@ http://purl.uniprot.org/uniprot/A0A7N4NP69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/9305:RAB3D ^@ http://purl.uniprot.org/uniprot/A0A7N4NRJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9305:TCF7L2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NG60|||http://purl.uniprot.org/uniprot/A0A7N4P2P3|||http://purl.uniprot.org/uniprot/A0A7N4P9A7|||http://purl.uniprot.org/uniprot/G3WYE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9305:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/G3W6D5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:CRH ^@ http://purl.uniprot.org/uniprot/A0A7N4P8Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9305:NBN ^@ http://purl.uniprot.org/uniprot/G3VFB2|||http://purl.uniprot.org/uniprot/G3VFB3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/9305:LOC100920675 ^@ http://purl.uniprot.org/uniprot/G3W7H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:HIF1A ^@ http://purl.uniprot.org/uniprot/G3WFI3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:LOC100919431 ^@ http://purl.uniprot.org/uniprot/G3WT88 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:ATAT1 ^@ http://purl.uniprot.org/uniprot/G3VXS2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/9305:CHMP4C ^@ http://purl.uniprot.org/uniprot/G3WAS6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9305:LOC100925292 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100922314 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVS5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:RP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PFAS ^@ http://purl.uniprot.org/uniprot/G3WG54 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/9305:C6H4orf47 ^@ http://purl.uniprot.org/uniprot/G3WHR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0602 family.|||centrosome http://togogenome.org/gene/9305:ARF5 ^@ http://purl.uniprot.org/uniprot/G3WQM0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9305:ACTR6 ^@ http://purl.uniprot.org/uniprot/G3WAN7 ^@ Similarity ^@ Belongs to the actin family. ARP6 subfamily. http://togogenome.org/gene/9305:RFFL ^@ http://purl.uniprot.org/uniprot/A0A7N4NRT6|||http://purl.uniprot.org/uniprot/A0A7N4PU08 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9305:LOC100931042 ^@ http://purl.uniprot.org/uniprot/G3W4X4 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9305:SRSF5 ^@ http://purl.uniprot.org/uniprot/G3VJA0 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/9305:LOC100914080 ^@ http://purl.uniprot.org/uniprot/G3VIE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/G3VR62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PFKP ^@ http://purl.uniprot.org/uniprot/A0A7N4NQ17 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:NEMP1 ^@ http://purl.uniprot.org/uniprot/G3VTU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9305:SELENBP1 ^@ http://purl.uniprot.org/uniprot/G3WNJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9305:NEU2 ^@ http://purl.uniprot.org/uniprot/G3VZV5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9305:LOC100914034 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SEMA3C ^@ http://purl.uniprot.org/uniprot/G3VSX2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:TMEM88 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9305:FAM216A ^@ http://purl.uniprot.org/uniprot/G3WP71 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9305:DDAH2 ^@ http://purl.uniprot.org/uniprot/G3VW52 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9305:FLCN ^@ http://purl.uniprot.org/uniprot/A0A7N4P0L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9305:TMEM186 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9305:HOXB2 ^@ http://purl.uniprot.org/uniprot/G3WFW2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100933475 ^@ http://purl.uniprot.org/uniprot/G3WJB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A7N4P7P6|||http://purl.uniprot.org/uniprot/G3WHE0 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9305:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:CENPQ ^@ http://purl.uniprot.org/uniprot/G3VKL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/9305:ABHD1 ^@ http://purl.uniprot.org/uniprot/G3WG86 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9305:LOC100924617 ^@ http://purl.uniprot.org/uniprot/G3VPW6 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9305:LOC100928152 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100927632 ^@ http://purl.uniprot.org/uniprot/G3X2C6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A7N4PWS6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/9305:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A7N4PYP6 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9305:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/G3WFU4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:DUSP16 ^@ http://purl.uniprot.org/uniprot/G3WI08 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9305:DUSP10 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ96 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9305:CEP162 ^@ http://purl.uniprot.org/uniprot/G3VCM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/9305:LOC100924906 ^@ http://purl.uniprot.org/uniprot/G3WXL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TPRA1 ^@ http://purl.uniprot.org/uniprot/G3WBT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9305:MFSD10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUS7|||http://purl.uniprot.org/uniprot/G3WD42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CSNK2B ^@ http://purl.uniprot.org/uniprot/A0A7N4NV50|||http://purl.uniprot.org/uniprot/G3VEQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/9305:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A7N4NU76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:ABCB11 ^@ http://purl.uniprot.org/uniprot/G3WW89 ^@ Subcellular Location Annotation ^@ Endosome http://togogenome.org/gene/9305:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZ86 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9305:CDH10 ^@ http://purl.uniprot.org/uniprot/G3W0K6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PROC ^@ http://purl.uniprot.org/uniprot/A0A7N4P981 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:FLAD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGG8 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9305:NOP56 ^@ http://purl.uniprot.org/uniprot/G3WXS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/9305:PSMC1 ^@ http://purl.uniprot.org/uniprot/G3WWW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:FFAR1 ^@ http://purl.uniprot.org/uniprot/G3VX52 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:PIGV ^@ http://purl.uniprot.org/uniprot/G3WLI5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9305:LPIN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZE5|||http://purl.uniprot.org/uniprot/G3VZS7 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9305:ACTG2 ^@ http://purl.uniprot.org/uniprot/G3VP69 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V220 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9305:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q2B3|||http://purl.uniprot.org/uniprot/G3WKN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:MSTO1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI03|||http://purl.uniprot.org/uniprot/G3WE78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Mitochondrion outer membrane http://togogenome.org/gene/9305:CHMP2A ^@ http://purl.uniprot.org/uniprot/G3VR36 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9305:MINDY3 ^@ http://purl.uniprot.org/uniprot/G3WFZ5 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9305:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1B2|||http://purl.uniprot.org/uniprot/G3W4F8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9305:SLA ^@ http://purl.uniprot.org/uniprot/A0A7N4PAV3|||http://purl.uniprot.org/uniprot/A0A7N4PWC4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A7N4NT29 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:IMP4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMJ4|||http://purl.uniprot.org/uniprot/G3W2A1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:LOC100917667 ^@ http://purl.uniprot.org/uniprot/G3W2X9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:FH ^@ http://purl.uniprot.org/uniprot/G3WGT2 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9305:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0T8|||http://purl.uniprot.org/uniprot/A0A7N4P3U0|||http://purl.uniprot.org/uniprot/A0A7N4PCQ1|||http://purl.uniprot.org/uniprot/A0A7N4PUP6 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9305:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A7N4PRY9 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9305:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm http://togogenome.org/gene/9305:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ41|||http://purl.uniprot.org/uniprot/G3W4K2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:NDUFB3 ^@ http://purl.uniprot.org/uniprot/G3WKB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:ME2 ^@ http://purl.uniprot.org/uniprot/G3WM32 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9305:ABAT ^@ http://purl.uniprot.org/uniprot/G3WIN3 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9305:LOC100927715 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKZ5 ^@ Function|||Similarity ^@ Belongs to the MS4A family.|||May be involved in signal transduction as a component of a multimeric receptor complex. http://togogenome.org/gene/9305:NPTX2 ^@ http://purl.uniprot.org/uniprot/G3WXE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100917788 ^@ http://purl.uniprot.org/uniprot/A0A7N4NP49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ADRB2 ^@ http://purl.uniprot.org/uniprot/G3WFD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/9305:ANAPC13 ^@ http://purl.uniprot.org/uniprot/G3VX80 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9305:RNF43 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6E3|||http://purl.uniprot.org/uniprot/G3WAH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Belongs to the ZNRF3 family.|||Cell membrane|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9305:LOC100922760 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100921555 ^@ http://purl.uniprot.org/uniprot/G3W5I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9305:RPL9 ^@ http://purl.uniprot.org/uniprot/G3VR23 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/9305:LOC100929546 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NUDT12 ^@ http://purl.uniprot.org/uniprot/G3VKB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9305:PLIN1 ^@ http://purl.uniprot.org/uniprot/G3WLK6 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9305:TM6SF2 ^@ http://purl.uniprot.org/uniprot/G3WFS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100926676 ^@ http://purl.uniprot.org/uniprot/G3WEF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NPTX1 ^@ http://purl.uniprot.org/uniprot/G3VXC2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100931086 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRF7|||http://purl.uniprot.org/uniprot/G3WW12 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9305:PIP4P2 ^@ http://purl.uniprot.org/uniprot/G3WHM7 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9305:DPYD ^@ http://purl.uniprot.org/uniprot/G3WX52 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/9305:NTHL1 ^@ http://purl.uniprot.org/uniprot/G3WTH1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Interacts with YBX1.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9305:DBNDD2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYR9 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9305:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9305:LOC100913905 ^@ http://purl.uniprot.org/uniprot/G3VNT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:AMOTL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUL1 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9305:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVS6|||http://purl.uniprot.org/uniprot/G3WDR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9305:ATP5ME ^@ http://purl.uniprot.org/uniprot/A0A7N4NZF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:ESD ^@ http://purl.uniprot.org/uniprot/A0A7N4NP77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9305:TECPR1 ^@ http://purl.uniprot.org/uniprot/G3WSL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TECPR1 family.|||Lysosome membrane|||autophagosome membrane http://togogenome.org/gene/9305:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0W4|||http://purl.uniprot.org/uniprot/G3WID9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PIGS ^@ http://purl.uniprot.org/uniprot/G3WLL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:NKX6-3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:IL1RL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRK2 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9305:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/G3WL60 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100920614 ^@ http://purl.uniprot.org/uniprot/G3VX68 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9305:LOC100928175 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1I5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9305:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9305:HADH ^@ http://purl.uniprot.org/uniprot/A0A7N4NWL5|||http://purl.uniprot.org/uniprot/G3VRA3 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9305:LOC100926310 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQA8 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9305:LOC100932654 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:AP1S3 ^@ http://purl.uniprot.org/uniprot/G3WBM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9305:DPYSL3 ^@ http://purl.uniprot.org/uniprot/G3WM45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Cytoplasm|||Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.|||growth cone http://togogenome.org/gene/9305:IFI30 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUE7 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/9305:LIPH ^@ http://purl.uniprot.org/uniprot/G3WHF6|||http://purl.uniprot.org/uniprot/G3WHF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Membrane|||Secreted http://togogenome.org/gene/9305:PRMT5 ^@ http://purl.uniprot.org/uniprot/G3WII7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9305:LOC100934287 ^@ http://purl.uniprot.org/uniprot/A0A7N4NH95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/G3WTJ0 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PAQR7 ^@ http://purl.uniprot.org/uniprot/G3VTW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/G3WWQ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LNPK ^@ http://purl.uniprot.org/uniprot/A0A7N4P3K5|||http://purl.uniprot.org/uniprot/A0A7N4PHJ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9305:EPCAM ^@ http://purl.uniprot.org/uniprot/A0A7N4P304 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100923011 ^@ http://purl.uniprot.org/uniprot/A0A7N4V756 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PLOD3 ^@ http://purl.uniprot.org/uniprot/G3VFK0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9305:URAD ^@ http://purl.uniprot.org/uniprot/A0A7N4NNF6 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/9305:LOC100935365 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHJ0 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9305:GGT7 ^@ http://purl.uniprot.org/uniprot/G3X092 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9305:LOC100931609 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MTMR6 ^@ http://purl.uniprot.org/uniprot/G3WJM5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9305:DTNB ^@ http://purl.uniprot.org/uniprot/G3W6Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9305:PFKL ^@ http://purl.uniprot.org/uniprot/G3VRD2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100920666 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FZD7 ^@ http://purl.uniprot.org/uniprot/G3WII5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:GPR55 ^@ http://purl.uniprot.org/uniprot/G3VGI0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:CUL4B ^@ http://purl.uniprot.org/uniprot/G3WD56|||http://purl.uniprot.org/uniprot/G3WD57 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9305:LOC100932482 ^@ http://purl.uniprot.org/uniprot/G3WKX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9305:TSSK6 ^@ http://purl.uniprot.org/uniprot/G3VE92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:LOC100917582 ^@ http://purl.uniprot.org/uniprot/G3W033 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HSD17B7 ^@ http://purl.uniprot.org/uniprot/G3WM61 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9305:CYFIP1 ^@ http://purl.uniprot.org/uniprot/G3VTY7 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9305:LOC100913500 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEC0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9305:CA3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFF5|||http://purl.uniprot.org/uniprot/G3W652 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9305:RPF2 ^@ http://purl.uniprot.org/uniprot/G3VH44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9305:PRDM12 ^@ http://purl.uniprot.org/uniprot/A0A7N4P226 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Involved in the positive regulation of histone H3-K9 dimethylation.|||Nucleus http://togogenome.org/gene/9305:COG4 ^@ http://purl.uniprot.org/uniprot/G3VEL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9305:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0N2|||http://purl.uniprot.org/uniprot/G3X1A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:LOC100914101 ^@ http://purl.uniprot.org/uniprot/G3WBC3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/9305:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A7N4PXP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9305:LOC100920345 ^@ http://purl.uniprot.org/uniprot/A0A7N4PY12 ^@ Similarity ^@ Belongs to the lst-2 family. http://togogenome.org/gene/9305:LEO1 ^@ http://purl.uniprot.org/uniprot/G3WWT3 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/9305:LOC100919466 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6L1 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9305:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUX1 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9305:LOC100932664 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:ELP6 ^@ http://purl.uniprot.org/uniprot/G3VV31 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9305:LOC100921632 ^@ http://purl.uniprot.org/uniprot/G3WP05 ^@ Similarity|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer. http://togogenome.org/gene/9305:MON1A ^@ http://purl.uniprot.org/uniprot/G3X100 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9305:ATP6AP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P854 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9305:GMFB ^@ http://purl.uniprot.org/uniprot/A0A7N4PXR2 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9305:TMEM251 ^@ http://purl.uniprot.org/uniprot/A0A7N4V577 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM251 family.|||Membrane http://togogenome.org/gene/9305:LCK ^@ http://purl.uniprot.org/uniprot/A0A7N4PWR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9305:ARG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYQ3 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9305:CELF3 ^@ http://purl.uniprot.org/uniprot/G3WSZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:SIX1 ^@ http://purl.uniprot.org/uniprot/G3WSV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:LOC100926484 ^@ http://purl.uniprot.org/uniprot/A0A7N4V394 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9305:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7R2|||http://purl.uniprot.org/uniprot/G3W1X6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:LOC100923620 ^@ http://purl.uniprot.org/uniprot/G3VCB5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9305:CCNC ^@ http://purl.uniprot.org/uniprot/G3WIU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin C subfamily.|||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|||Nucleus http://togogenome.org/gene/9305:THBS1 ^@ http://purl.uniprot.org/uniprot/G3VTZ6 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:SLC10A3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NV32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9305:RRM2 ^@ http://purl.uniprot.org/uniprot/G3VT20 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9305:DBX1 ^@ http://purl.uniprot.org/uniprot/G3WEB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:FSCN2 ^@ http://purl.uniprot.org/uniprot/G3WLZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9305:POC5 ^@ http://purl.uniprot.org/uniprot/G3W3R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/9305:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9305:PCOLCE ^@ http://purl.uniprot.org/uniprot/G3W598 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:LOC100926134 ^@ http://purl.uniprot.org/uniprot/G3VSJ6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9305:TNFRSF1B ^@ http://purl.uniprot.org/uniprot/G3W5A4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PSPH ^@ http://purl.uniprot.org/uniprot/G3W5X4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9305:IARS2 ^@ http://purl.uniprot.org/uniprot/G3VQJ8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:PLXNA2 ^@ http://purl.uniprot.org/uniprot/G3VZ33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LRRC8B ^@ http://purl.uniprot.org/uniprot/A0A7N4PXL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4T2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9305:DXO ^@ http://purl.uniprot.org/uniprot/G3W4Y1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/9305:CNPY1 ^@ http://purl.uniprot.org/uniprot/G3WN37 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9305:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9305:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNU7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/9305:RARB ^@ http://purl.uniprot.org/uniprot/G3W7J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:ALOXE3 ^@ http://purl.uniprot.org/uniprot/G3WKD6 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:QRSL1 ^@ http://purl.uniprot.org/uniprot/G3WKL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9305:GDNF ^@ http://purl.uniprot.org/uniprot/G3WXP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9305:C3H11orf87 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PTGER4 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7E4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9305:VDAC1 ^@ http://purl.uniprot.org/uniprot/G3WYY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9305:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWX1|||http://purl.uniprot.org/uniprot/G3X0G3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/9305:DHX8 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100929438 ^@ http://purl.uniprot.org/uniprot/G3W3C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919671 ^@ http://purl.uniprot.org/uniprot/G3VSB9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9305:LOC100920297 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJT5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:DBX2 ^@ http://purl.uniprot.org/uniprot/G3WHC4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TMED1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P095 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9305:LOC100929157 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2Q4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:FEZ2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX00 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9305:GATA3 ^@ http://purl.uniprot.org/uniprot/G3X1W3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:MAL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4E4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100913409 ^@ http://purl.uniprot.org/uniprot/G3WRV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A7N4P280 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9305:LOC100928342 ^@ http://purl.uniprot.org/uniprot/G3W913 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9305:XPO6 ^@ http://purl.uniprot.org/uniprot/G3WLI8|||http://purl.uniprot.org/uniprot/G3WLI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:ACO1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V694 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.|||Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).|||cytosol http://togogenome.org/gene/9305:ITPR3 ^@ http://purl.uniprot.org/uniprot/G3VVL0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9305:LOC100934965 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9305:ATOH7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYK3 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/9305:SRMS ^@ http://purl.uniprot.org/uniprot/G3X1L2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:LOC100932503 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVY4 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9305:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/G3X0M3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100916229 ^@ http://purl.uniprot.org/uniprot/G3WGH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LTA ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9305:PTGDS ^@ http://purl.uniprot.org/uniprot/G3W418 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum|||perinuclear region http://togogenome.org/gene/9305:HLX ^@ http://purl.uniprot.org/uniprot/G3WF98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q105 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9305:LOC100913363 ^@ http://purl.uniprot.org/uniprot/G3WWQ6 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9305:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A7N4UXC7|||http://purl.uniprot.org/uniprot/G3W8Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9305:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9305:PSAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4N9 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/9305:MOS ^@ http://purl.uniprot.org/uniprot/A0A7N4PAL1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:ATF4 ^@ http://purl.uniprot.org/uniprot/G3WM84 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9305:TAF1D ^@ http://purl.uniprot.org/uniprot/A0A7N4PM38 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9305:GCLM ^@ http://purl.uniprot.org/uniprot/G3VR55 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/9305:LOC100924868 ^@ http://purl.uniprot.org/uniprot/G3VI92 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:STEAP2 ^@ http://purl.uniprot.org/uniprot/G3WY55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9305:LOC100929960 ^@ http://purl.uniprot.org/uniprot/G3VMB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:AGK ^@ http://purl.uniprot.org/uniprot/G3WYZ9|||http://purl.uniprot.org/uniprot/G3WZ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9305:FAM83B ^@ http://purl.uniprot.org/uniprot/A0A7N4P7L5 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9305:ARHGDIA ^@ http://purl.uniprot.org/uniprot/A0A7N4NX53 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9305:SLC46A2 ^@ http://purl.uniprot.org/uniprot/G3W3V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGT3|||http://purl.uniprot.org/uniprot/G3VFI7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9305:LOC100917076 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIH7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9305:GDPD1 ^@ http://purl.uniprot.org/uniprot/G3WYW4 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9305:MRRF ^@ http://purl.uniprot.org/uniprot/A0A7N4PBL2|||http://purl.uniprot.org/uniprot/A0A7N4UZH2|||http://purl.uniprot.org/uniprot/G3WGQ0 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9305:NUP205 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHX7|||http://purl.uniprot.org/uniprot/G3WNP3 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9305:UFC1 ^@ http://purl.uniprot.org/uniprot/G3WVB6 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9305:ARSL ^@ http://purl.uniprot.org/uniprot/A0A7N4PR83|||http://purl.uniprot.org/uniprot/G3W3T8 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9305:GBGT1 ^@ http://purl.uniprot.org/uniprot/G3W2W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Membrane http://togogenome.org/gene/9305:PTGES3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/9305:UBA2 ^@ http://purl.uniprot.org/uniprot/G3VHX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus|||The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. http://togogenome.org/gene/9305:LOC100917427 ^@ http://purl.uniprot.org/uniprot/A0A7N4P570 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:TMCC2 ^@ http://purl.uniprot.org/uniprot/G3WKV5|||http://purl.uniprot.org/uniprot/G3WKV6 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9305:RHO ^@ http://purl.uniprot.org/uniprot/G3WKC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9305:TSPAN31 ^@ http://purl.uniprot.org/uniprot/A0A7N4PY65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:LOC100933692 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9305:LOC105750377 ^@ http://purl.uniprot.org/uniprot/G3X3W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane http://togogenome.org/gene/9305:HMOX2 ^@ http://purl.uniprot.org/uniprot/G3VI39 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9305:LOC100923284 ^@ http://purl.uniprot.org/uniprot/G3WJQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Interacts with FDX1/adrenodoxin.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:LOC100914600 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MCHR2 ^@ http://purl.uniprot.org/uniprot/G3WNT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:KIF2C ^@ http://purl.uniprot.org/uniprot/G3WD38 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:CXCL9 ^@ http://purl.uniprot.org/uniprot/G3VMQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9305:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/G3VE33 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9305:DUS3L ^@ http://purl.uniprot.org/uniprot/G3WMI6 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/9305:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/G3WM94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:GLRB ^@ http://purl.uniprot.org/uniprot/G3VXM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9305:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXB3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9305:LYZ ^@ http://purl.uniprot.org/uniprot/G3VQQ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9305:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKM2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9305:GPR119 ^@ http://purl.uniprot.org/uniprot/G3WUU5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:POMK ^@ http://purl.uniprot.org/uniprot/G3X2V1 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/9305:IP6K3 ^@ http://purl.uniprot.org/uniprot/G3W0T7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9305:ANPEP ^@ http://purl.uniprot.org/uniprot/G3WIS7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9305:AFF4 ^@ http://purl.uniprot.org/uniprot/G3WJ80 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9305:RPL38 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQ00 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9305:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A7N4NTK6 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9305:STN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1A6|||http://purl.uniprot.org/uniprot/A0A7N4UX52|||http://purl.uniprot.org/uniprot/G3WZ40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9305:BUD31 ^@ http://purl.uniprot.org/uniprot/G3WCW9|||http://purl.uniprot.org/uniprot/G3WCX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9305:KIN ^@ http://purl.uniprot.org/uniprot/G3X0R6 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9305:SFMBT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100935126 ^@ http://purl.uniprot.org/uniprot/G3WRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PN44|||http://purl.uniprot.org/uniprot/G3W5U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9305:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9305:ELF4 ^@ http://purl.uniprot.org/uniprot/G3WSV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:SCFD1 ^@ http://purl.uniprot.org/uniprot/G3WPR2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9305:ADSS2 ^@ http://purl.uniprot.org/uniprot/G3VCR3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9305:TXNDC5 ^@ http://purl.uniprot.org/uniprot/G3WIJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9305:MAB21L2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mab-21 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:LOC100931375 ^@ http://purl.uniprot.org/uniprot/A0A7N4V137 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC105749163 ^@ http://purl.uniprot.org/uniprot/G3VNH1 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9305:S100A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/9305:ATP5F1B ^@ http://purl.uniprot.org/uniprot/G3VIJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9305:DYDC1 ^@ http://purl.uniprot.org/uniprot/G3VRZ5|||http://purl.uniprot.org/uniprot/G3VRZ8 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9305:GTF3C5 ^@ http://purl.uniprot.org/uniprot/G3VYD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100934161 ^@ http://purl.uniprot.org/uniprot/G3VMJ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:ABCC8 ^@ http://purl.uniprot.org/uniprot/G3WZ95 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/9305:ANXA5 ^@ http://purl.uniprot.org/uniprot/G3VRW3 ^@ Domain|||Function|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. http://togogenome.org/gene/9305:SLC22A3 ^@ http://purl.uniprot.org/uniprot/G3WVY7 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9305:LOC100923367 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MMUT ^@ http://purl.uniprot.org/uniprot/A0A7N4PSG3|||http://purl.uniprot.org/uniprot/G3VF42 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9305:POSTN ^@ http://purl.uniprot.org/uniprot/A0A7N4NKJ8|||http://purl.uniprot.org/uniprot/G3WCH7|||http://purl.uniprot.org/uniprot/G3WCH8 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9305:GLCE ^@ http://purl.uniprot.org/uniprot/A0A7N4PQJ6 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9305:LOC100926339 ^@ http://purl.uniprot.org/uniprot/G3VSR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:AP4B1 ^@ http://purl.uniprot.org/uniprot/G3WJ27 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9305:SPDYE4 ^@ http://purl.uniprot.org/uniprot/G3VNV2 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9305:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/G3X041 ^@ Subcellular Location Annotation ^@ cell cortex|||dendritic spine http://togogenome.org/gene/9305:LOC100919855 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFK9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:LYRM7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9305:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/G3WJM1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:LOC100932699 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CALY ^@ http://purl.uniprot.org/uniprot/A0A7N4V560 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9305:DUSP3 ^@ http://purl.uniprot.org/uniprot/G3VW43 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9305:LOC100930341 ^@ http://purl.uniprot.org/uniprot/G3W499 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC105749409 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXL3|||http://purl.uniprot.org/uniprot/G3WSP8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9305:TRIM3 ^@ http://purl.uniprot.org/uniprot/G3VZK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9305:SEZ6L2 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q079|||http://purl.uniprot.org/uniprot/G3W7Z1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:DHX9 ^@ http://purl.uniprot.org/uniprot/G3W358 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9305:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/G3WUN0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100918456 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ZNF532 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTY6|||http://purl.uniprot.org/uniprot/G3WME9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9305:LOC100926557 ^@ http://purl.uniprot.org/uniprot/G3WFM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100929057 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PCID2 ^@ http://purl.uniprot.org/uniprot/G3WWX0 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9305:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJL7|||http://purl.uniprot.org/uniprot/G3WN90 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:DBR1 ^@ http://purl.uniprot.org/uniprot/G3VX73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/9305:DSEL ^@ http://purl.uniprot.org/uniprot/A0A7N4PU93 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9305:LOC100923285 ^@ http://purl.uniprot.org/uniprot/A0A7N4P187 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100921340 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100928781 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9305:FAM151B ^@ http://purl.uniprot.org/uniprot/A0A7N4V2X6 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9305:LOC100926600 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRX8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9305:KCNE1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDU8 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9305:TCEANC ^@ http://purl.uniprot.org/uniprot/G3W2F5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:HMBS ^@ http://purl.uniprot.org/uniprot/A0A7N4P5Q5 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9305:EIF3B ^@ http://purl.uniprot.org/uniprot/G3VDD6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||The RRM domain mediates interaction with EIF3J. http://togogenome.org/gene/9305:RNASEH1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI31 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9305:NGB ^@ http://purl.uniprot.org/uniprot/G3W066 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9305:PRDX2 ^@ http://purl.uniprot.org/uniprot/G3WSH0 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9305:IFIH1 ^@ http://purl.uniprot.org/uniprot/G3X0K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9305:LOC100933830 ^@ http://purl.uniprot.org/uniprot/G3VGJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RPL26L1 ^@ http://purl.uniprot.org/uniprot/G3WCU1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9305:GLI3 ^@ http://purl.uniprot.org/uniprot/G3W7A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:PPP1R11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZ39 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9305:PDK2 ^@ http://purl.uniprot.org/uniprot/G3WI52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9305:HTR1B ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ94 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.|||Homodimer. Heterodimer with HTR1D.|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Membrane|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/9305:ERBB2 ^@ http://purl.uniprot.org/uniprot/G3WQQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9305:MED6 ^@ http://purl.uniprot.org/uniprot/G3X381 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9305:DRD2 ^@ http://purl.uniprot.org/uniprot/G3WPM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:PROM1 ^@ http://purl.uniprot.org/uniprot/G3X1S3|||http://purl.uniprot.org/uniprot/G3X1S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9305:LBX1 ^@ http://purl.uniprot.org/uniprot/G3WHH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100933215 ^@ http://purl.uniprot.org/uniprot/G3WIN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PLA2G2F ^@ http://purl.uniprot.org/uniprot/G3WH25 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9305:LOC100927323 ^@ http://purl.uniprot.org/uniprot/G3WTI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CDC6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NX35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9305:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9305:PLSCR1 ^@ http://purl.uniprot.org/uniprot/G3WXY4 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9305:WASF3 ^@ http://purl.uniprot.org/uniprot/G3WKI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9305:SDHD ^@ http://purl.uniprot.org/uniprot/A0A7N4PK29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9305:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UWY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:ISM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHS7 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9305:LOC100934607 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1K1|||http://purl.uniprot.org/uniprot/G3WEJ5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:APMAP ^@ http://purl.uniprot.org/uniprot/G3VIF2 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9305:HHIPL2 ^@ http://purl.uniprot.org/uniprot/G3VZT1 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/9305:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9305:VSX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0P5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:GPRC6A ^@ http://purl.uniprot.org/uniprot/G3W3X2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:HTR7 ^@ http://purl.uniprot.org/uniprot/G3W0X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DIS3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTT5|||http://purl.uniprot.org/uniprot/G3WQZ4 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9305:IFT46 ^@ http://purl.uniprot.org/uniprot/G3WGE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9305:ENKUR ^@ http://purl.uniprot.org/uniprot/G3WWY9 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9305:LOC100934510 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:KATNA1 ^@ http://purl.uniprot.org/uniprot/G3WY86 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9305:EGFL6 ^@ http://purl.uniprot.org/uniprot/G3W3J1 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:KCNK18 ^@ http://purl.uniprot.org/uniprot/G3WW85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9305:LOC100920925 ^@ http://purl.uniprot.org/uniprot/G3VT84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GNRH1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/9305:PDCL3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8M6 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9305:LOC100922565 ^@ http://purl.uniprot.org/uniprot/G3W0P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ADM ^@ http://purl.uniprot.org/uniprot/A0A7N4NM04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9305:LOC100929922 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:AGXT ^@ http://purl.uniprot.org/uniprot/A0A7N4P6E7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9305:B9D1 ^@ http://purl.uniprot.org/uniprot/G3WJF3 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9305:BCDIN3D ^@ http://purl.uniprot.org/uniprot/G3WBR1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9305:LOC100925873 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHP2|||http://purl.uniprot.org/uniprot/G3VJC1 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PANX1 ^@ http://purl.uniprot.org/uniprot/G3X191 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9305:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRL6|||http://purl.uniprot.org/uniprot/G3VSS5 ^@ Subcellular Location Annotation ^@ Nucleus|||extracellular exosome http://togogenome.org/gene/9305:CNN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P186 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9305:CRYBG1 ^@ http://purl.uniprot.org/uniprot/G3WI39 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:TUBE1 ^@ http://purl.uniprot.org/uniprot/G3WLJ8 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9305:SLC37A1 ^@ http://purl.uniprot.org/uniprot/G3WSH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9305:PEMT ^@ http://purl.uniprot.org/uniprot/A0A7N4NTH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:PTGIS ^@ http://purl.uniprot.org/uniprot/G3VRG3|||http://purl.uniprot.org/uniprot/G3VRG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:KCNS3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNF9|||http://purl.uniprot.org/uniprot/G3VE71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GPR171 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQW7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:PPP1R14C ^@ http://purl.uniprot.org/uniprot/G3X024 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Inhibitor of PPP1CA.|||Membrane http://togogenome.org/gene/9305:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NX16 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9305:LOC100935017 ^@ http://purl.uniprot.org/uniprot/G3VLW3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9305:C2H10orf53 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLZ3 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9305:LOC100919756 ^@ http://purl.uniprot.org/uniprot/G3WP57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRU8|||http://purl.uniprot.org/uniprot/G3W2Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LTV1 ^@ http://purl.uniprot.org/uniprot/G3WQC6 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9305:SUMF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8U8|||http://purl.uniprot.org/uniprot/G3W5U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9305:ARSK ^@ http://purl.uniprot.org/uniprot/G3WFM9 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9305:SLC25A19 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:LOC100926104 ^@ http://purl.uniprot.org/uniprot/G3WJ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:SNRPD1 ^@ http://purl.uniprot.org/uniprot/G3WED5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9305:LOC100916277 ^@ http://purl.uniprot.org/uniprot/G3VDQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919131 ^@ http://purl.uniprot.org/uniprot/G3WER9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9305:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHE7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9305:LOC100924949 ^@ http://purl.uniprot.org/uniprot/G3VGV6 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9305:TNFSF8 ^@ http://purl.uniprot.org/uniprot/G3W2K3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9305:CHST12 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY58|||http://purl.uniprot.org/uniprot/G3VUI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:HLF ^@ http://purl.uniprot.org/uniprot/A0A7N4P5Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9305:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRK0 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9305:CLTB ^@ http://purl.uniprot.org/uniprot/A0A7N4UY97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9305:SLC6A15 ^@ http://purl.uniprot.org/uniprot/G3VKX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9305:LOC100915337 ^@ http://purl.uniprot.org/uniprot/G3VJJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CLK1 ^@ http://purl.uniprot.org/uniprot/G3WGP6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:CAMLG ^@ http://purl.uniprot.org/uniprot/G3WPA4 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/9305:P2RY8 ^@ http://purl.uniprot.org/uniprot/A0A7N4V018 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LHCGR ^@ http://purl.uniprot.org/uniprot/G3WP77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/9305:MS4A1 ^@ http://purl.uniprot.org/uniprot/G3VYV0 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9305:SRPX ^@ http://purl.uniprot.org/uniprot/G3VGE3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:TBX15 ^@ http://purl.uniprot.org/uniprot/G3WHS9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:BPIFC ^@ http://purl.uniprot.org/uniprot/G3WUX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9305:MOCS2 ^@ http://purl.uniprot.org/uniprot/G3VIP0|||http://purl.uniprot.org/uniprot/G3VIP1 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/9305:CCZ1 ^@ http://purl.uniprot.org/uniprot/G3WN95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCZ1 family.|||Lysosome membrane http://togogenome.org/gene/9305:MS4A5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUX3 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9305:LOC100920543 ^@ http://purl.uniprot.org/uniprot/G3W2L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HPS3 ^@ http://purl.uniprot.org/uniprot/G5EA74 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9305:SLC7A10 ^@ http://purl.uniprot.org/uniprot/G3WRY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SGK2 ^@ http://purl.uniprot.org/uniprot/G3VL16 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5I5 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/9305:LOC100924919 ^@ http://purl.uniprot.org/uniprot/G3VTI3|||http://purl.uniprot.org/uniprot/G3W1M2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9305:LOC100924253 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CDK2 ^@ http://purl.uniprot.org/uniprot/G3W161 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:TMEM126B ^@ http://purl.uniprot.org/uniprot/A0A7N4PBU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SDHC ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1P4|||http://purl.uniprot.org/uniprot/G3WWM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9305:LOC100915852 ^@ http://purl.uniprot.org/uniprot/G3VQC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PKNOX1 ^@ http://purl.uniprot.org/uniprot/G3WWP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9305:AGTR2 ^@ http://purl.uniprot.org/uniprot/G3W2S8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9305:LOC100933884 ^@ http://purl.uniprot.org/uniprot/A0A7N4V4U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:RAF1 ^@ http://purl.uniprot.org/uniprot/G3WC19 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9305:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A7N4P876 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9305:LOC100934104 ^@ http://purl.uniprot.org/uniprot/G3W1J2 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9305:LOC100930816 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ND4 ^@ http://purl.uniprot.org/uniprot/J9RRN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:TRMT6 ^@ http://purl.uniprot.org/uniprot/G3WAV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/9305:CCM2L ^@ http://purl.uniprot.org/uniprot/G3WF83 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9305:ADORA1 ^@ http://purl.uniprot.org/uniprot/G3WUH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9305:LIX1 ^@ http://purl.uniprot.org/uniprot/G3VU47 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9305:GLA ^@ http://purl.uniprot.org/uniprot/G3WK18 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9305:ELF3 ^@ http://purl.uniprot.org/uniprot/G3VD68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:STAT5B ^@ http://purl.uniprot.org/uniprot/G3VMK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:SERPINA12 ^@ http://purl.uniprot.org/uniprot/G3VP32 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:GNB3 ^@ http://purl.uniprot.org/uniprot/G3WTV2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9305:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A7N4Q104|||http://purl.uniprot.org/uniprot/G3W3Q1 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9305:LOC100925102 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGL9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9305:CCT2 ^@ http://purl.uniprot.org/uniprot/G3VSN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9305:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9305:CNR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.|||Interacts (via C-terminus) with CNRIP1.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/9305:LOC100931920 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACTC1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PH39 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:LOC100925098 ^@ http://purl.uniprot.org/uniprot/G3WDR0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9305:PRKCD ^@ http://purl.uniprot.org/uniprot/G3W312 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9305:TMEM54 ^@ http://purl.uniprot.org/uniprot/G3WGH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9305:LOC100916252 ^@ http://purl.uniprot.org/uniprot/G3VKF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GCM2 ^@ http://purl.uniprot.org/uniprot/G3WAA7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:SDR42E1 ^@ http://purl.uniprot.org/uniprot/G3WH03 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9305:STK38L ^@ http://purl.uniprot.org/uniprot/A0A7N4NS21 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:AKAP8 ^@ http://purl.uniprot.org/uniprot/A0A7N4V752|||http://purl.uniprot.org/uniprot/G3W9H9 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9305:NKX6-1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P550 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:PIGO ^@ http://purl.uniprot.org/uniprot/A0A7N4V7P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:C7 ^@ http://purl.uniprot.org/uniprot/G3WK51 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:COG2 ^@ http://purl.uniprot.org/uniprot/G3WZ34 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9305:PDYN ^@ http://purl.uniprot.org/uniprot/G3WIV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opiod activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9305:MYH11 ^@ http://purl.uniprot.org/uniprot/G3VZB7|||http://purl.uniprot.org/uniprot/G3VZB8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9305:RPA2 ^@ http://purl.uniprot.org/uniprot/G3WRB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/9305:ACTB ^@ http://purl.uniprot.org/uniprot/A0A7N4PW14 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:SRD5A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9305:MRPL4 ^@ http://purl.uniprot.org/uniprot/G3W356 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/9305:F13A1 ^@ http://purl.uniprot.org/uniprot/G3WM90 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9305:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5J3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||cilium membrane http://togogenome.org/gene/9305:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTD7 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/9305:LOC100918627 ^@ http://purl.uniprot.org/uniprot/G3W3F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100921188 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100922176 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:CHMP7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PN67 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9305:ATP6V1A ^@ http://purl.uniprot.org/uniprot/G3VZS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9305:FTO ^@ http://purl.uniprot.org/uniprot/A0A7N4NFL0|||http://purl.uniprot.org/uniprot/G3W5C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fto family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9305:SLC19A3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5F8|||http://purl.uniprot.org/uniprot/G3W9D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/9305:TMOD4 ^@ http://purl.uniprot.org/uniprot/G3WLA6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:KYNU ^@ http://purl.uniprot.org/uniprot/G3W586 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100919806 ^@ http://purl.uniprot.org/uniprot/G3VUR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:P2RY4 ^@ http://purl.uniprot.org/uniprot/G3VUB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SLC15A2 ^@ http://purl.uniprot.org/uniprot/G3W3P9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9305:GKAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFU8|||http://purl.uniprot.org/uniprot/A0A7N4PYG4|||http://purl.uniprot.org/uniprot/G3WYY7 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9305:PPM1G ^@ http://purl.uniprot.org/uniprot/G3WKM5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9305:TOP2A ^@ http://purl.uniprot.org/uniprot/G3WFK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9305:MED4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN52|||http://purl.uniprot.org/uniprot/G3VS79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9305:LOC100923720 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GMNN ^@ http://purl.uniprot.org/uniprot/A0A7N4PAZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9305:HDDC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9305:NPY ^@ http://purl.uniprot.org/uniprot/G3W5E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9305:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A7N4V770 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9305:SGCD ^@ http://purl.uniprot.org/uniprot/G3WIA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9305:SPON2 ^@ http://purl.uniprot.org/uniprot/G3WG82 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9305:NUBP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKD1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/9305:TFDP1 ^@ http://purl.uniprot.org/uniprot/G3WQY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9305:LOC100928381 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYV1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC100932442 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3C4 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9305:GFRA2 ^@ http://purl.uniprot.org/uniprot/G3WYE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. http://togogenome.org/gene/9305:C3H2orf88 ^@ http://purl.uniprot.org/uniprot/A0A7N4P728 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SLC2A2 ^@ http://purl.uniprot.org/uniprot/G3WFV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LACTB2 ^@ http://purl.uniprot.org/uniprot/G3WJP4 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9305:STC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI81 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9305:ZCCHC17 ^@ http://purl.uniprot.org/uniprot/A0A7N4PR70 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:LOC100915440 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9305:HOXB5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9305:SLC39A7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PU98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100925549 ^@ http://purl.uniprot.org/uniprot/A0A7N4NI61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DHX58 ^@ http://purl.uniprot.org/uniprot/G3VV49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9305:ACTL7A ^@ http://purl.uniprot.org/uniprot/G3W6D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9305:LOC100913189 ^@ http://purl.uniprot.org/uniprot/A0A7N4P099 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100921514 ^@ http://purl.uniprot.org/uniprot/G3W9U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:YIPF5 ^@ http://purl.uniprot.org/uniprot/G3VN34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9305:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A7N4PB29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDI family.|||Cytoplasm|||Endosome|||Nucleus http://togogenome.org/gene/9305:WNT10B ^@ http://purl.uniprot.org/uniprot/G3VID6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:MEGF10 ^@ http://purl.uniprot.org/uniprot/G3WDB2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:VPS45 ^@ http://purl.uniprot.org/uniprot/G3VWS6 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9305:UPK1B ^@ http://purl.uniprot.org/uniprot/G3VIT7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).|||Membrane http://togogenome.org/gene/9305:SMC3 ^@ http://purl.uniprot.org/uniprot/G3WLM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9305:IRF1 ^@ http://purl.uniprot.org/uniprot/G3W5G7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:RHBDF2 ^@ http://purl.uniprot.org/uniprot/G3WUB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/9305:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A7N4P995 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9305:ABHD12 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZJ0|||http://purl.uniprot.org/uniprot/G3WYT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serine esterase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LOC100931633 ^@ http://purl.uniprot.org/uniprot/G3VRS4 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9305:ADAM15 ^@ http://purl.uniprot.org/uniprot/A0A7N4NL81 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:CNIH1 ^@ http://purl.uniprot.org/uniprot/G3W593 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9305:TCN1 ^@ http://purl.uniprot.org/uniprot/G3VY47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9305:IKBKB ^@ http://purl.uniprot.org/uniprot/G3WZY2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:SHOX ^@ http://purl.uniprot.org/uniprot/A0A7N4P7Q7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TRIM46 ^@ http://purl.uniprot.org/uniprot/A0A7N4V4P3|||http://purl.uniprot.org/uniprot/G3VZK9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:SGCB ^@ http://purl.uniprot.org/uniprot/A0A7N4PGL3|||http://purl.uniprot.org/uniprot/G3WZR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9305:NUBP1 ^@ http://purl.uniprot.org/uniprot/G3W2D6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9305:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MYOZ1 ^@ http://purl.uniprot.org/uniprot/G3VXA0 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9305:F3 ^@ http://purl.uniprot.org/uniprot/G3W1I9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/9305:LOC100925532 ^@ http://purl.uniprot.org/uniprot/G3VM30 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMD8 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9305:MCM3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9305:DOC2A ^@ http://purl.uniprot.org/uniprot/G3W9J1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BTG4 ^@ http://purl.uniprot.org/uniprot/A0A7N4P564 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9305:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/G3VY57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9305:LOC100929561 ^@ http://purl.uniprot.org/uniprot/G3VVF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RAD51D ^@ http://purl.uniprot.org/uniprot/G3VPQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/9305:LOC100931394 ^@ http://purl.uniprot.org/uniprot/G3W6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TLCD3A ^@ http://purl.uniprot.org/uniprot/A0A7N4PXJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100917912 ^@ http://purl.uniprot.org/uniprot/G3VJQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919316 ^@ http://purl.uniprot.org/uniprot/G3VFK8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9305:LOC100921257 ^@ http://purl.uniprot.org/uniprot/G3WAF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MAPK13 ^@ http://purl.uniprot.org/uniprot/G3VTJ1 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9305:NDUFB10 ^@ http://purl.uniprot.org/uniprot/G3WR40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:CLCN4 ^@ http://purl.uniprot.org/uniprot/G3WSV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9305:SLC5A2 ^@ http://purl.uniprot.org/uniprot/G3WLY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9305:LOC100920106 ^@ http://purl.uniprot.org/uniprot/G3VPX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LHX1 ^@ http://purl.uniprot.org/uniprot/G3W9N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:AEBP1 ^@ http://purl.uniprot.org/uniprot/G3WNF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9305:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A7N4NVL5 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9305:DLL1 ^@ http://purl.uniprot.org/uniprot/G3WP27 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9305:LOC100932646 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9305:CNDP2 ^@ http://purl.uniprot.org/uniprot/G3W6F7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9305:PLAC8 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHA1|||http://purl.uniprot.org/uniprot/G3W0J4 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9305:MZT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NX51 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/9305:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:KCNH3 ^@ http://purl.uniprot.org/uniprot/G3W2R5 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9305:LOC100915609 ^@ http://purl.uniprot.org/uniprot/G3WFI1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/9305:KRT8 ^@ http://purl.uniprot.org/uniprot/G3VJ06 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:GAST ^@ http://purl.uniprot.org/uniprot/G3VSY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9305:LOC100919597 ^@ http://purl.uniprot.org/uniprot/G3VJN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:CAPN5 ^@ http://purl.uniprot.org/uniprot/G3W892 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9305:UBE2T ^@ http://purl.uniprot.org/uniprot/G3WJY5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9305:DLK1 ^@ http://purl.uniprot.org/uniprot/G3W4W8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100926738 ^@ http://purl.uniprot.org/uniprot/G3W2E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:FHL5 ^@ http://purl.uniprot.org/uniprot/G3WRC5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9305:EDN3 ^@ http://purl.uniprot.org/uniprot/G3WC75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9305:KIAA1324L ^@ http://purl.uniprot.org/uniprot/G3X339 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100918073 ^@ http://purl.uniprot.org/uniprot/G3VUD2 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9305:LOC100926426 ^@ http://purl.uniprot.org/uniprot/G3VE07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FRZB ^@ http://purl.uniprot.org/uniprot/G3VWL8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9305:INHBE ^@ http://purl.uniprot.org/uniprot/G3VWI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9305:AGPAT3 ^@ http://purl.uniprot.org/uniprot/G3W425 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9305:TUBB ^@ http://purl.uniprot.org/uniprot/A0A7N4PPV2|||http://purl.uniprot.org/uniprot/G3W109 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9305:PCK1 ^@ http://purl.uniprot.org/uniprot/G3WHW0 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9305:LOC100931874 ^@ http://purl.uniprot.org/uniprot/G3VQK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MEIS1 ^@ http://purl.uniprot.org/uniprot/G3WVM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC100934209 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EIF2B2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V241 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9305:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A7N4PAM2|||http://purl.uniprot.org/uniprot/G3WZ69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Nucleus http://togogenome.org/gene/9305:SUB1 ^@ http://purl.uniprot.org/uniprot/G3WQE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9305:CSN2 ^@ http://purl.uniprot.org/uniprot/G3VIN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-casein family.|||Important role in determination of the surface properties of the casein micelles.|||Secreted http://togogenome.org/gene/9305:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKM7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9305:COQ7 ^@ http://purl.uniprot.org/uniprot/G3X113 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPV1 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9305:SPINK4 ^@ http://purl.uniprot.org/uniprot/G3W7N4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:LOC100929883 ^@ http://purl.uniprot.org/uniprot/A0A7N4PER7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9305:GPR18 ^@ http://purl.uniprot.org/uniprot/G3WFL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9305:DSC2 ^@ http://purl.uniprot.org/uniprot/G3W7D8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9305:CHRM3 ^@ http://purl.uniprot.org/uniprot/G3WNI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9305:CDX2 ^@ http://purl.uniprot.org/uniprot/G3X060 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC100934385 ^@ http://purl.uniprot.org/uniprot/G3WEE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100934449 ^@ http://purl.uniprot.org/uniprot/G3VX59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9305:EIF5A ^@ http://purl.uniprot.org/uniprot/G3VY46 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/9305:LMX1B ^@ http://purl.uniprot.org/uniprot/G3W872 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:UNC50 ^@ http://purl.uniprot.org/uniprot/G3W5H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9305:LOC100920067 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FAN1 ^@ http://purl.uniprot.org/uniprot/G3WVX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/9305:KCNK1 ^@ http://purl.uniprot.org/uniprot/G3WDN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9305:MFSD11 ^@ http://purl.uniprot.org/uniprot/G3VT39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9305:ECHS1 ^@ http://purl.uniprot.org/uniprot/G3WB21 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9305:CTSS ^@ http://purl.uniprot.org/uniprot/G3WEW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9305:TLCD5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100921024 ^@ http://purl.uniprot.org/uniprot/G3WC29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EEF2KMT ^@ http://purl.uniprot.org/uniprot/G3WIA7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family. http://togogenome.org/gene/9305:LAMA1 ^@ http://purl.uniprot.org/uniprot/G3W7Z3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9305:SEPHS1 ^@ http://purl.uniprot.org/uniprot/G3WRE8 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9305:BPGM ^@ http://purl.uniprot.org/uniprot/A0A7N4V4D3 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9305:SLITRK1 ^@ http://purl.uniprot.org/uniprot/G3VKJ3 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9305:POU5F1 ^@ http://purl.uniprot.org/uniprot/G3VJ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-5 subfamily.|||Nucleus http://togogenome.org/gene/9305:CD68 ^@ http://purl.uniprot.org/uniprot/G3WSZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9305:ZPBP2 ^@ http://purl.uniprot.org/uniprot/G3WNZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted http://togogenome.org/gene/9305:GDF5 ^@ http://purl.uniprot.org/uniprot/G3X2G9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:ANXA1 ^@ http://purl.uniprot.org/uniprot/G3W8D2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9305:THBS4 ^@ http://purl.uniprot.org/uniprot/G3W8V6 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:FERMT1 ^@ http://purl.uniprot.org/uniprot/G3W6M7 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9305:CFDP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V362 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/9305:MTIF2 ^@ http://purl.uniprot.org/uniprot/G3VPE4 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9305:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9305:PAIP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTA8 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9305:YARS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V156|||http://purl.uniprot.org/uniprot/G3WEK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/9305:RXRG ^@ http://purl.uniprot.org/uniprot/A0A7N4V348 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9305:OLA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PU27 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/9305:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9305:SLC29A3 ^@ http://purl.uniprot.org/uniprot/G3W5U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9305:CCDC93 ^@ http://purl.uniprot.org/uniprot/G3X323 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC93 family.|||Early endosome http://togogenome.org/gene/9305:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NI14|||http://purl.uniprot.org/uniprot/G3X391 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9305:SCOC ^@ http://purl.uniprot.org/uniprot/A0A7N4PXI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9305:SNX20 ^@ http://purl.uniprot.org/uniprot/G3X3U9 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9305:IMMP1L ^@ http://purl.uniprot.org/uniprot/A0A7N4PUF5|||http://purl.uniprot.org/uniprot/G3WRU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:NTSR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:FSCN1 ^@ http://purl.uniprot.org/uniprot/G3VLI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9305:DDX52 ^@ http://purl.uniprot.org/uniprot/G3WLV5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9305:LOC100918140 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NI68|||http://purl.uniprot.org/uniprot/G3VK12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9305:TLR8 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZA7|||http://purl.uniprot.org/uniprot/G3WLZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9305:TRMT5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/9305:GPR132 ^@ http://purl.uniprot.org/uniprot/G3VL42 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:GFRA3 ^@ http://purl.uniprot.org/uniprot/G3WCY4 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9305:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:LOC100924464 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZB6 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9305:MRPL47 ^@ http://purl.uniprot.org/uniprot/G3WY60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL29 family.|||Mitochondrion http://togogenome.org/gene/9305:PAPSS1 ^@ http://purl.uniprot.org/uniprot/G3W5D5 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9305:LOC100916556 ^@ http://purl.uniprot.org/uniprot/G3VP65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9305:SLC7A8 ^@ http://purl.uniprot.org/uniprot/G3WMM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:PDX1 ^@ http://purl.uniprot.org/uniprot/G3X001 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9305:DNASE2B ^@ http://purl.uniprot.org/uniprot/G3WZP0 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9305:LOC100916701 ^@ http://purl.uniprot.org/uniprot/G3WPA7 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9305:AURKA ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9305:KIF20B ^@ http://purl.uniprot.org/uniprot/G3WKT2|||http://purl.uniprot.org/uniprot/G3WKT3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:C8G ^@ http://purl.uniprot.org/uniprot/A0A7N4PBE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9305:GNRHR ^@ http://purl.uniprot.org/uniprot/G3W0T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100914286 ^@ http://purl.uniprot.org/uniprot/G3WTD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100928631 ^@ http://purl.uniprot.org/uniprot/G3VV08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SAR1B ^@ http://purl.uniprot.org/uniprot/G3WQF3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9305:LMF1 ^@ http://purl.uniprot.org/uniprot/G3WR27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lipase maturation factor family.|||Endoplasmic reticulum membrane|||Involved in the maturation of specific proteins in the endoplasmic reticulum.|||Membrane http://togogenome.org/gene/9305:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZV3|||http://purl.uniprot.org/uniprot/G3WJQ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:LOC100934853 ^@ http://purl.uniprot.org/uniprot/G3VXV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BMP5 ^@ http://purl.uniprot.org/uniprot/G3W5W3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:LOC100913370 ^@ http://purl.uniprot.org/uniprot/G3VSX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ATP8B4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIQ7|||http://purl.uniprot.org/uniprot/G3VZD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9305:LOC100917327 ^@ http://purl.uniprot.org/uniprot/G3WM20 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:LOC100927692 ^@ http://purl.uniprot.org/uniprot/G3VTY4 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/9305:SNCG ^@ http://purl.uniprot.org/uniprot/G3VPA3 ^@ Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. http://togogenome.org/gene/9305:URGCP ^@ http://purl.uniprot.org/uniprot/A0A7N4PXD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9305:CTSC ^@ http://purl.uniprot.org/uniprot/A0A7N4PWD4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9305:GAP43 ^@ http://purl.uniprot.org/uniprot/G3W8Q7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9305:RPL13 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY33 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9305:GJB1 ^@ http://purl.uniprot.org/uniprot/G3W9X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:LOC100932757 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100921853 ^@ http://purl.uniprot.org/uniprot/A0A7N4V624 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TAF15 ^@ http://purl.uniprot.org/uniprot/G3VK30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9305:LOC100932290 ^@ http://purl.uniprot.org/uniprot/G3WNJ3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:ADGRG5 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXB8|||http://purl.uniprot.org/uniprot/G3VMD6|||http://purl.uniprot.org/uniprot/G3VMD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:GJA8 ^@ http://purl.uniprot.org/uniprot/G3X210 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:GPR137 ^@ http://purl.uniprot.org/uniprot/G3VSP2 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9305:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYR3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9305:SLC4A1 ^@ http://purl.uniprot.org/uniprot/G3WSG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.|||Membrane http://togogenome.org/gene/9305:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V3P4|||http://purl.uniprot.org/uniprot/G3W9D3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9305:BPNT1 ^@ http://purl.uniprot.org/uniprot/G3VN28 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9305:LSM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/9305:TLR5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9305:LOC100926334 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTK8 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9305:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A7N4V224 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LOC100921928 ^@ http://purl.uniprot.org/uniprot/G3WMV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:XRCC4 ^@ http://purl.uniprot.org/uniprot/G3W756 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9305:NCAPH ^@ http://purl.uniprot.org/uniprot/G3X235 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9305:NUSAP1 ^@ http://purl.uniprot.org/uniprot/G3WWX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/9305:FGF11 ^@ http://purl.uniprot.org/uniprot/A0A7N4NY15 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9305:GPR68 ^@ http://purl.uniprot.org/uniprot/A0A7N4V760 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LRP3 ^@ http://purl.uniprot.org/uniprot/G3WSE7|||http://purl.uniprot.org/uniprot/G3WSE8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PMVK ^@ http://purl.uniprot.org/uniprot/G3VJZ4 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9305:SH3RF2 ^@ http://purl.uniprot.org/uniprot/G3VGM7 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9305:ND1 ^@ http://purl.uniprot.org/uniprot/G1FKB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:GUCA2A ^@ http://purl.uniprot.org/uniprot/A0A7N4PU88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9305:CACFD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9305:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8M3 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9305:LOC100934536 ^@ http://purl.uniprot.org/uniprot/A0A7N4PP91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:YIPF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V214 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9305:PLD4 ^@ http://purl.uniprot.org/uniprot/G3VUX0 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9305:LOC100927853 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:TACC3 ^@ http://purl.uniprot.org/uniprot/G3WKQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100926452 ^@ http://purl.uniprot.org/uniprot/G3VU44 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9305:ORC2 ^@ http://purl.uniprot.org/uniprot/G3WHS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9305:LOC100916628 ^@ http://purl.uniprot.org/uniprot/G3WK57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V317|||http://purl.uniprot.org/uniprot/G3VZ86 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9305:CAB39L ^@ http://purl.uniprot.org/uniprot/A0A7N4P5F8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9305:LMOD3 ^@ http://purl.uniprot.org/uniprot/G3WVM1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:LOC100925541 ^@ http://purl.uniprot.org/uniprot/A0A7N4V170 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9305:RPL19 ^@ http://purl.uniprot.org/uniprot/G3WVF4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9305:LOC100915180 ^@ http://purl.uniprot.org/uniprot/G3WUB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9305:NOTUM ^@ http://purl.uniprot.org/uniprot/A0A7N4NI26 ^@ Similarity ^@ Belongs to the pectinacetylesterase family. Notum subfamily. http://togogenome.org/gene/9305:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI82 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9305:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS23|||http://purl.uniprot.org/uniprot/G3WYS1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Binds 1 Ca(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||Secreted http://togogenome.org/gene/9305:PLPPR4 ^@ http://purl.uniprot.org/uniprot/G3WCP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9305:POLG ^@ http://purl.uniprot.org/uniprot/G3WRQ4 ^@ Function|||Subcellular Location Annotation ^@ Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/9305:MSRB2 ^@ http://purl.uniprot.org/uniprot/G3VY02 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9305:KCNMB1 ^@ http://purl.uniprot.org/uniprot/G3X3H5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9305:ACSS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P524|||http://purl.uniprot.org/uniprot/G3X0M2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9305:PSMA7 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7S8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9305:LDHB ^@ http://purl.uniprot.org/uniprot/G3WRT3 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9305:PRORP ^@ http://purl.uniprot.org/uniprot/A0A7N4PPR7 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9305:CIAO3 ^@ http://purl.uniprot.org/uniprot/G3WEQ3 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9305:ATM ^@ http://purl.uniprot.org/uniprot/G3WB56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Cytoplasmic vesicle|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks. http://togogenome.org/gene/9305:LOC100928604 ^@ http://purl.uniprot.org/uniprot/G3VBY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A7N4PS39|||http://purl.uniprot.org/uniprot/G3VQX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:QTRT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM82 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/9305:TLR6 ^@ http://purl.uniprot.org/uniprot/G3W9V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9305:HSP90B1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIG4|||http://purl.uniprot.org/uniprot/G3VE83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9305:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:F10 ^@ http://purl.uniprot.org/uniprot/G3WXN7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:ISCA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PA31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9305:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9305:PKM ^@ http://purl.uniprot.org/uniprot/A0A7N4V2Q6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9305:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola|||sarcomere http://togogenome.org/gene/9305:PLCG2 ^@ http://purl.uniprot.org/uniprot/G3WDW2 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9305:XIAP ^@ http://purl.uniprot.org/uniprot/G3WUX1 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9305:CUTA ^@ http://purl.uniprot.org/uniprot/G3VH61 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9305:LOC100923721 ^@ http://purl.uniprot.org/uniprot/G3WCG3|||http://purl.uniprot.org/uniprot/G3WCQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DYRK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P6R6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9305:AP1M2 ^@ http://purl.uniprot.org/uniprot/G3VRS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9305:JPH3 ^@ http://purl.uniprot.org/uniprot/G3WYM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9305:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A7N4NNE8|||http://purl.uniprot.org/uniprot/G3WKL3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9305:SLC9A3R2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3T1 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/9305:PMPCA ^@ http://purl.uniprot.org/uniprot/G3VZ76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion matrix|||Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. http://togogenome.org/gene/9305:FAM124B ^@ http://purl.uniprot.org/uniprot/G3VQJ4 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9305:KMO ^@ http://purl.uniprot.org/uniprot/G3WFS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/9305:CCDC58 ^@ http://purl.uniprot.org/uniprot/G3WKT9 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9305:SNX21 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBL4|||http://purl.uniprot.org/uniprot/G3VFN3 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9305:CHGA ^@ http://purl.uniprot.org/uniprot/G3WCF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9305:RXRB ^@ http://purl.uniprot.org/uniprot/G3VV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9305:KCNA6 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100931085 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A7N4NV65|||http://purl.uniprot.org/uniprot/G3WT08 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:MFAP1 ^@ http://purl.uniprot.org/uniprot/G3WP54 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9305:TAS2R38 ^@ http://purl.uniprot.org/uniprot/G3VUK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9305:LOC100920270 ^@ http://purl.uniprot.org/uniprot/G3WBZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9305:SGO2 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9305:ALKAL2 ^@ http://purl.uniprot.org/uniprot/G3VQN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9305:IST1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9305:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIJ7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9305:LOC100914350 ^@ http://purl.uniprot.org/uniprot/G3VGR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:VGLL4 ^@ http://purl.uniprot.org/uniprot/G3X343 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9305:LOC100913506 ^@ http://purl.uniprot.org/uniprot/A0A7N4V739 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HBM ^@ http://purl.uniprot.org/uniprot/A0A7N4PYH5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9305:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYG9|||http://purl.uniprot.org/uniprot/A0A7N4PXN4|||http://purl.uniprot.org/uniprot/G3WYD3 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9305:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9305:LOC100923904 ^@ http://purl.uniprot.org/uniprot/G3WGM3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYC1|||http://purl.uniprot.org/uniprot/G3WSF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9305:USP15 ^@ http://purl.uniprot.org/uniprot/G3WIA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9305:DLD ^@ http://purl.uniprot.org/uniprot/G3VMS5 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9305:LOC100913525 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9305:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P4C4 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9305:NSUN7 ^@ http://purl.uniprot.org/uniprot/G3WY64 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:ALAD ^@ http://purl.uniprot.org/uniprot/A0A7N4PY89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer; active form. Homohexamer; low activity form. http://togogenome.org/gene/9305:MED23 ^@ http://purl.uniprot.org/uniprot/A0A7N4P785 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9305:C3H11orf54 ^@ http://purl.uniprot.org/uniprot/G3VST9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9305:SPTAN1 ^@ http://purl.uniprot.org/uniprot/G3X3E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9305:MMD ^@ http://purl.uniprot.org/uniprot/A0A7N4V2L4|||http://purl.uniprot.org/uniprot/G3WQJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9305:LOC100932786 ^@ http://purl.uniprot.org/uniprot/G3WJU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9305:DUSP6 ^@ http://purl.uniprot.org/uniprot/G3VNF8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9305:GOLT1A ^@ http://purl.uniprot.org/uniprot/G3VFL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9305:HNF1B ^@ http://purl.uniprot.org/uniprot/G3VRI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9305:WARS1 ^@ http://purl.uniprot.org/uniprot/G3WLE5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:TLR10 ^@ http://purl.uniprot.org/uniprot/G3WAH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9305:LAGE3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMU0 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9305:GJB5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NQE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9305:SLC45A1 ^@ http://purl.uniprot.org/uniprot/G3WCA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:VOPP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.|||Membrane http://togogenome.org/gene/9305:ITPRIP ^@ http://purl.uniprot.org/uniprot/A0A7N4NUY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Cell membrane|||Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9305:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/G3WMK0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9305:TSEN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWR9|||http://purl.uniprot.org/uniprot/G3WA36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9305:PGM3 ^@ http://purl.uniprot.org/uniprot/G3WU51 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/9305:KRT36 ^@ http://purl.uniprot.org/uniprot/G3VPL3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:LOC100929313 ^@ http://purl.uniprot.org/uniprot/G3VK96|||http://purl.uniprot.org/uniprot/G3VNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DEUP1 ^@ http://purl.uniprot.org/uniprot/G3VZA6|||http://purl.uniprot.org/uniprot/G3VZA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP63 family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100924633 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:NUMB ^@ http://purl.uniprot.org/uniprot/A0A7N4P5X1|||http://purl.uniprot.org/uniprot/A0A7N4PW51 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9305:LOC100918626 ^@ http://purl.uniprot.org/uniprot/G3WK84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:PENK ^@ http://purl.uniprot.org/uniprot/A0A7N4PCL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9305:METRNL ^@ http://purl.uniprot.org/uniprot/G3VCQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the meteorin family.|||Secreted http://togogenome.org/gene/9305:TIPIN ^@ http://purl.uniprot.org/uniprot/G3WCJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9305:THUMPD3 ^@ http://purl.uniprot.org/uniprot/G3WNL4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9305:RIC8B ^@ http://purl.uniprot.org/uniprot/G3WKC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9305:P2RY2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LARP7 ^@ http://purl.uniprot.org/uniprot/G3W1W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LARP7 family.|||nucleoplasm http://togogenome.org/gene/9305:COPZ1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9305:LOC100925121 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PTPN21 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9305:LOC100922782 ^@ http://purl.uniprot.org/uniprot/G3VRX2 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9305:BANF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NR52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:STAC3 ^@ http://purl.uniprot.org/uniprot/G3VKM5 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9305:LOC100916112 ^@ http://purl.uniprot.org/uniprot/A0A7N4NH48|||http://purl.uniprot.org/uniprot/A0A7N4PYM7|||http://purl.uniprot.org/uniprot/A0A7N4UZV4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:OSBPL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P768|||http://purl.uniprot.org/uniprot/A0A7N4P8T3 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9305:DRC1 ^@ http://purl.uniprot.org/uniprot/G3VJS1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC1 family.|||Component of the nexin-dynein regulatory complex (N-DRC).|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9305:LOC100913210 ^@ http://purl.uniprot.org/uniprot/G3VM57 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/9305:LOC100916813 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHT5 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:ALG8 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:GNB2 ^@ http://purl.uniprot.org/uniprot/G3W3Y2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9305:LOC100920038 ^@ http://purl.uniprot.org/uniprot/G3VMS6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:LOC100928798 ^@ http://purl.uniprot.org/uniprot/G3WDG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GIPC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V825 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9305:FTCD ^@ http://purl.uniprot.org/uniprot/G3VL73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds and promotes bundling of vimentin filaments originating from the Golgi.|||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|||Golgi apparatus|||Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.|||In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|||In the N-terminal section; belongs to the formiminotransferase family.|||centriole http://togogenome.org/gene/9305:LOC100924358 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0K0|||http://purl.uniprot.org/uniprot/G3VEI0 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9305:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:GAS6 ^@ http://purl.uniprot.org/uniprot/G3WMN3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:POPDC3 ^@ http://purl.uniprot.org/uniprot/G3WKA6 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9305:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMA3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A7N4NQS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9305:LOC100924186 ^@ http://purl.uniprot.org/uniprot/G3VC53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GABRA6 ^@ http://purl.uniprot.org/uniprot/G3VQ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:AVPR1B ^@ http://purl.uniprot.org/uniprot/G3WX95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9305:FGF22 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBF5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9305:OPRK1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with SLC9A3R1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/9305:UCKL1 ^@ http://purl.uniprot.org/uniprot/G3WXS6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9305:IL4R ^@ http://purl.uniprot.org/uniprot/A0A7N4PYF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9305:STXBP1 ^@ http://purl.uniprot.org/uniprot/G3X0W3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9305:LOC100923217 ^@ http://purl.uniprot.org/uniprot/A0A7N4UZL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LMOD1 ^@ http://purl.uniprot.org/uniprot/G3WB36 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9305:LOC100920407 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ITGB3BP ^@ http://purl.uniprot.org/uniprot/A0A7N4PDY8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription coregulator that can have both coactivator and corepressor functions.|||centromere|||kinetochore http://togogenome.org/gene/9305:SLC6A12 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Interacts with LIN7C.|||Membrane|||Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. http://togogenome.org/gene/9305:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDV3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:KLC4 ^@ http://purl.uniprot.org/uniprot/G3WFJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9305:LOC100935036 ^@ http://purl.uniprot.org/uniprot/G3WPU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GPRC5D ^@ http://purl.uniprot.org/uniprot/G3W940 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:GNL2 ^@ http://purl.uniprot.org/uniprot/G3WG05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9305:MYMK ^@ http://purl.uniprot.org/uniprot/G3VZY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100924997 ^@ http://purl.uniprot.org/uniprot/G3WDE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SLC7A7 ^@ http://purl.uniprot.org/uniprot/G3WFV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MAEA ^@ http://purl.uniprot.org/uniprot/A0A7N4NTW4|||http://purl.uniprot.org/uniprot/A0A7N4V611 ^@ Subcellular Location Annotation ^@ Nucleus matrix http://togogenome.org/gene/9305:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/G3WYP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9305:RRP12 ^@ http://purl.uniprot.org/uniprot/G3X1M2 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/9305:ATP23 ^@ http://purl.uniprot.org/uniprot/G3WBB2 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9305:HBS1L ^@ http://purl.uniprot.org/uniprot/G3WKA1 ^@ Subunit ^@ Interacts with the SKI complex. http://togogenome.org/gene/9305:LOC100923021 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ADGRG3 ^@ http://purl.uniprot.org/uniprot/G3VVG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100921186 ^@ http://purl.uniprot.org/uniprot/A0A7N4NGE8|||http://purl.uniprot.org/uniprot/G3W3X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9305:DDX24 ^@ http://purl.uniprot.org/uniprot/G3W4Z2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9305:CCT4 ^@ http://purl.uniprot.org/uniprot/G3W3A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9305:SOX9 ^@ http://purl.uniprot.org/uniprot/A0A7N4UX98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:DYNC1LI2 ^@ http://purl.uniprot.org/uniprot/G3VN53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9305:HS6ST1 ^@ http://purl.uniprot.org/uniprot/G3WKD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9305:APOA4 ^@ http://purl.uniprot.org/uniprot/G3WJL0 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9305:PCSK2 ^@ http://purl.uniprot.org/uniprot/G3W9J3 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9305:RIOK3 ^@ http://purl.uniprot.org/uniprot/G3WEK7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/9305:DUS4L ^@ http://purl.uniprot.org/uniprot/G3WHV9 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9305:CDK10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRD3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLK6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9305:LOC100933860 ^@ http://purl.uniprot.org/uniprot/G3WVN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PRDM8 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:AKR1D1 ^@ http://purl.uniprot.org/uniprot/G3VPF6 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9305:LOC100932392 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:CCDC103 ^@ http://purl.uniprot.org/uniprot/G3W332 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9305:LOC100932534 ^@ http://purl.uniprot.org/uniprot/A0A7N4PB86 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:DGKE ^@ http://purl.uniprot.org/uniprot/G3VEH5 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9305:ETS2 ^@ http://purl.uniprot.org/uniprot/G3VY84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9305:LOC100918963 ^@ http://purl.uniprot.org/uniprot/G3WSP3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:KCNA5 ^@ http://purl.uniprot.org/uniprot/G3WDK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ACOT13 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTR7 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9305:KRT19 ^@ http://purl.uniprot.org/uniprot/G3VKB3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:NAA10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PR93 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9305:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLV6|||http://purl.uniprot.org/uniprot/A0A7N4PQ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9305:P4HB ^@ http://purl.uniprot.org/uniprot/A0A7N4V284 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9305:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:COPE ^@ http://purl.uniprot.org/uniprot/A0A7N4PVN0|||http://purl.uniprot.org/uniprot/G3WB38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9305:LOC100930308 ^@ http://purl.uniprot.org/uniprot/G3X1Z9 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9305:GRP ^@ http://purl.uniprot.org/uniprot/G3WHY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.|||Secreted|||neuron projection|||secretory vesicle lumen http://togogenome.org/gene/9305:SLC52A3 ^@ http://purl.uniprot.org/uniprot/G3W5B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9305:HOXB7 ^@ http://purl.uniprot.org/uniprot/A0A7N4PE53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9305:LOC100920534 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHN7|||http://purl.uniprot.org/uniprot/G3VLX0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:NT5C3B ^@ http://purl.uniprot.org/uniprot/A0A7N4PXB1|||http://purl.uniprot.org/uniprot/G3VGG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9305:IPO4 ^@ http://purl.uniprot.org/uniprot/A0A7N4P330 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:METTL14 ^@ http://purl.uniprot.org/uniprot/G3WMS9 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9305:CDKAL1 ^@ http://purl.uniprot.org/uniprot/G3WJ31 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:FECH ^@ http://purl.uniprot.org/uniprot/G3X087 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:LOC100925856 ^@ http://purl.uniprot.org/uniprot/G3VS69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DDIT4L ^@ http://purl.uniprot.org/uniprot/A0A7N4NUX7 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9305:ATL3 ^@ http://purl.uniprot.org/uniprot/G3VGY7 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9305:NFYB ^@ http://purl.uniprot.org/uniprot/A0A7N4V586 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9305:AQP5 ^@ http://purl.uniprot.org/uniprot/G3VMA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9305:CHD8 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRE4|||http://purl.uniprot.org/uniprot/G3W1S9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9305:AFP ^@ http://purl.uniprot.org/uniprot/G3WQV0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9305:OSTC ^@ http://purl.uniprot.org/uniprot/G3W2G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9305:BCAS2 ^@ http://purl.uniprot.org/uniprot/G3W2X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/9305:ALOX12B ^@ http://purl.uniprot.org/uniprot/G3WKY8 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:TNR ^@ http://purl.uniprot.org/uniprot/A0A7N4NX58|||http://purl.uniprot.org/uniprot/G3WNL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9305:GPCPD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUA5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9305:LOC100933728 ^@ http://purl.uniprot.org/uniprot/G3VD24 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:TANGO6 ^@ http://purl.uniprot.org/uniprot/G3WCW1 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/9305:FMOD ^@ http://purl.uniprot.org/uniprot/G3WXK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.|||Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to type I and type II collagen.|||extracellular matrix http://togogenome.org/gene/9305:FAM133B ^@ http://purl.uniprot.org/uniprot/A0A7N4P5U1 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9305:CFB ^@ http://purl.uniprot.org/uniprot/G3W3U6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:PPIH ^@ http://purl.uniprot.org/uniprot/G3WLS4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9305:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A7N4P832 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9305:SARAF ^@ http://purl.uniprot.org/uniprot/G3WF88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9305:ENTPD8 ^@ http://purl.uniprot.org/uniprot/G3WE81 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9305:TTC36 ^@ http://purl.uniprot.org/uniprot/G3WH04 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/9305:LOC100914861 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MVD ^@ http://purl.uniprot.org/uniprot/G3VUM6 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/9305:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9305:EMC2 ^@ http://purl.uniprot.org/uniprot/G3WMK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/9305:AFF1 ^@ http://purl.uniprot.org/uniprot/G3VNN4|||http://purl.uniprot.org/uniprot/G3VNN5 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9305:TMEM98 ^@ http://purl.uniprot.org/uniprot/G3X0F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9305:PTAR1 ^@ http://purl.uniprot.org/uniprot/G3VRK5 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9305:DAXX ^@ http://purl.uniprot.org/uniprot/A0A7N4P8S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAXX family.|||Cytoplasm|||PML body|||centromere|||nucleolus|||nucleoplasm http://togogenome.org/gene/9305:LOC100933712 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7B5|||http://purl.uniprot.org/uniprot/G3VVW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9305:LOC100926163 ^@ http://purl.uniprot.org/uniprot/G3WLB6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:TSHR ^@ http://purl.uniprot.org/uniprot/G3VPN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/9305:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXC3|||http://purl.uniprot.org/uniprot/G3WQE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:HSD17B4 ^@ http://purl.uniprot.org/uniprot/G3VS44 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9305:LOC100923912 ^@ http://purl.uniprot.org/uniprot/A0A7N4V105|||http://purl.uniprot.org/uniprot/G3VKN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:RRP15 ^@ http://purl.uniprot.org/uniprot/G3WYZ1 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9305:PAPPA ^@ http://purl.uniprot.org/uniprot/G3WAX2 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LGMN ^@ http://purl.uniprot.org/uniprot/G3W763 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9305:SIRT3 ^@ http://purl.uniprot.org/uniprot/G3W512 ^@ Cofactor|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9305:SYT2 ^@ http://purl.uniprot.org/uniprot/G3WNY7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/9305:FSHR ^@ http://purl.uniprot.org/uniprot/G3WGP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/9305:WASHC5 ^@ http://purl.uniprot.org/uniprot/G3VVD7|||http://purl.uniprot.org/uniprot/G3VVD8 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9305:SMOC1 ^@ http://purl.uniprot.org/uniprot/G3X3H7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100922880 ^@ http://purl.uniprot.org/uniprot/G3WU75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Membrane http://togogenome.org/gene/9305:VIRMA ^@ http://purl.uniprot.org/uniprot/G3WY88 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9305:PREPL ^@ http://purl.uniprot.org/uniprot/A0A7N4UZ79|||http://purl.uniprot.org/uniprot/G3X244 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9305:HTR3A ^@ http://purl.uniprot.org/uniprot/A0A7N4V7H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9305:MTM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9Q0|||http://purl.uniprot.org/uniprot/G3WVR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cell membrane|||Late endosome|||filopodium|||ruffle|||sarcomere http://togogenome.org/gene/9305:APOC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Secreted http://togogenome.org/gene/9305:ACTBL2 ^@ http://purl.uniprot.org/uniprot/G3W5K4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:HS6ST2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9305:POLR2B ^@ http://purl.uniprot.org/uniprot/G3WU38 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9305:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM96 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9305:NDE1 ^@ http://purl.uniprot.org/uniprot/G3W2T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9305:LOC100917307 ^@ http://purl.uniprot.org/uniprot/G3WH33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:CDKN2AIP ^@ http://purl.uniprot.org/uniprot/A0A7N4NXM3 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9305:CDO1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFC9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9305:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PS60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9305:UCN3 ^@ http://purl.uniprot.org/uniprot/G3VGX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9305:GRK1 ^@ http://purl.uniprot.org/uniprot/G3WQG6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9305:LOC100930813 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DSCC1 ^@ http://purl.uniprot.org/uniprot/G3X094 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9305:LOC100927726 ^@ http://purl.uniprot.org/uniprot/G3W2M7 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9305:KCNK15 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9305:BRD1 ^@ http://purl.uniprot.org/uniprot/G3WWF4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:EIPR1 ^@ http://purl.uniprot.org/uniprot/G3WNG2 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/9305:LOC100915895 ^@ http://purl.uniprot.org/uniprot/G3VIZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum|||perinuclear region http://togogenome.org/gene/9305:LOC100933586 ^@ http://purl.uniprot.org/uniprot/G3VZT4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9305:SLC7A14 ^@ http://purl.uniprot.org/uniprot/G3WN39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:BACE1 ^@ http://purl.uniprot.org/uniprot/G3WAG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9305:LOC116419008 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTK1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:SENP3 ^@ http://purl.uniprot.org/uniprot/G3WT25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9305:GLDC ^@ http://purl.uniprot.org/uniprot/G3VSM1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9305:LPCAT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQH0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9305:SERPINB10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYX0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:LOC100921730 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q2D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PSMB3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:SLC22A2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDE0|||http://purl.uniprot.org/uniprot/G3WUZ0 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9305:SLC9A2 ^@ http://purl.uniprot.org/uniprot/G3VXQ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9305:LALBA ^@ http://purl.uniprot.org/uniprot/G3VEF8 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9305:CASP3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMK7|||http://purl.uniprot.org/uniprot/G3W5D0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9305:DMAC2L ^@ http://purl.uniprot.org/uniprot/A0A7N4PZJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP synthase subunit s family.|||Homotetramer. Associates with ATP synthase.|||Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:LOC100926824 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC105750535 ^@ http://purl.uniprot.org/uniprot/G3WLP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:LOC100917086 ^@ http://purl.uniprot.org/uniprot/G3WEL2|||http://purl.uniprot.org/uniprot/G3WFE8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9305:ATXN3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMS7|||http://purl.uniprot.org/uniprot/G3W8T7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LOC100922468 ^@ http://purl.uniprot.org/uniprot/G3VBS4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:LOC100922751 ^@ http://purl.uniprot.org/uniprot/A0A7N4PEP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FICD ^@ http://purl.uniprot.org/uniprot/A0A7N4PSS5 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9305:GADD45G ^@ http://purl.uniprot.org/uniprot/G3VNU9 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9305:LSM4 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9305:SNAP23 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9305:LYVE1 ^@ http://purl.uniprot.org/uniprot/G3VKY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9305:MMS22L ^@ http://purl.uniprot.org/uniprot/G3WXB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9305:SNX5 ^@ http://purl.uniprot.org/uniprot/G3X2K2 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9305:GTF2H2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9305:LOC100931112 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LCAT ^@ http://purl.uniprot.org/uniprot/G3W0U4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9305:LOC100929967 ^@ http://purl.uniprot.org/uniprot/G3VH33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:HEXA ^@ http://purl.uniprot.org/uniprot/G3W2Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9305:TEKT5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PB14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9305:LOC100918000 ^@ http://purl.uniprot.org/uniprot/G3VJX7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9305:EZH2 ^@ http://purl.uniprot.org/uniprot/G3WZR8|||http://purl.uniprot.org/uniprot/G3WZR9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:LYPD6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9Q9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:SEC63 ^@ http://purl.uniprot.org/uniprot/G3WYZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100928760 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9305:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NUT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9305:TM2D2 ^@ http://purl.uniprot.org/uniprot/G3X2J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100933078 ^@ http://purl.uniprot.org/uniprot/A0A7N4PTJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9305:WARS2 ^@ http://purl.uniprot.org/uniprot/G3WKV9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9305:ACSM3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLG7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9305:LOC100928150 ^@ http://purl.uniprot.org/uniprot/G3WBY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TIMM8A ^@ http://purl.uniprot.org/uniprot/G3WKU9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9305:HIKESHI ^@ http://purl.uniprot.org/uniprot/G3WJQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9305:LOC100914102 ^@ http://purl.uniprot.org/uniprot/G3VRB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:GALNT12 ^@ http://purl.uniprot.org/uniprot/G3WYU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:PLTP ^@ http://purl.uniprot.org/uniprot/A0A7N4UYV2 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9305:PSEN2 ^@ http://purl.uniprot.org/uniprot/G3W889 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9305:GRAP ^@ http://purl.uniprot.org/uniprot/G3WER2 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/9305:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V5B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:GLO1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P6M0 ^@ Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9305:TMED10 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9305:KYAT3 ^@ http://purl.uniprot.org/uniprot/G3VLY8 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9305:LOC100925548 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:CDC26 ^@ http://purl.uniprot.org/uniprot/A0A7N4P836 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9305:LOC100930556 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ZFYVE26 ^@ http://purl.uniprot.org/uniprot/G3WH22 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.|||Midbody|||Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. http://togogenome.org/gene/9305:AIMP2 ^@ http://purl.uniprot.org/uniprot/G3WLJ4 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9305:GLRA3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVG9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9305:SBK2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9S6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:GABRA2 ^@ http://purl.uniprot.org/uniprot/G3WIL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9305:CXCL8 ^@ http://purl.uniprot.org/uniprot/G3WTP6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9305:RHPN2 ^@ http://purl.uniprot.org/uniprot/G3WUK3 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9305:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSZ5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9305:APH1B ^@ http://purl.uniprot.org/uniprot/A0A7N4P7D8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9305:MRPL54 ^@ http://purl.uniprot.org/uniprot/G3VI85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/9305:USP45 ^@ http://purl.uniprot.org/uniprot/G3WGY9|||http://purl.uniprot.org/uniprot/G3WGZ0 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9305:DBH ^@ http://purl.uniprot.org/uniprot/A0A7N4V4M9|||http://purl.uniprot.org/uniprot/G3W5W0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Conversion of dopamine to noradrenaline.|||Homotetramer; composed of two disulfide-linked dimers.|||chromaffin granule lumen|||chromaffin granule membrane|||secretory vesicle lumen|||secretory vesicle membrane http://togogenome.org/gene/9305:B3GNT3 ^@ http://purl.uniprot.org/uniprot/G3VLG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:MRPL58 ^@ http://purl.uniprot.org/uniprot/A0A7N4P169 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9305:PSMD5 ^@ http://purl.uniprot.org/uniprot/G3WXX1 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9305:RPL37 ^@ http://purl.uniprot.org/uniprot/G3WLW3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9305:CPB1 ^@ http://purl.uniprot.org/uniprot/G3VV32 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9305:NUP93 ^@ http://purl.uniprot.org/uniprot/G3WEE8|||http://purl.uniprot.org/uniprot/G3WEE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9305:BAK1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NH60|||http://purl.uniprot.org/uniprot/A0A7N4PCK9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9305:INPP5B ^@ http://purl.uniprot.org/uniprot/G3WMK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9305:PHACTR4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZ13|||http://purl.uniprot.org/uniprot/G3VWC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/9305:CXXC5 ^@ http://purl.uniprot.org/uniprot/G3WG38 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:RPS6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PGN1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/9305:OGFOD1 ^@ http://purl.uniprot.org/uniprot/G3W7F1 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9305:LOC100922058 ^@ http://purl.uniprot.org/uniprot/G3WF96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9305:SPIC ^@ http://purl.uniprot.org/uniprot/G3VU21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:HAUS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9305:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A7N4PU05 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9305:LOC100915848 ^@ http://purl.uniprot.org/uniprot/G3VHL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MACIR ^@ http://purl.uniprot.org/uniprot/G3VV77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9305:FAM20A ^@ http://purl.uniprot.org/uniprot/G3VZ47 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9305:GABRP ^@ http://purl.uniprot.org/uniprot/G3VDS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:SLC35B4 ^@ http://purl.uniprot.org/uniprot/G3VVB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9305:DVL2 ^@ http://purl.uniprot.org/uniprot/G3W2D2 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9305:GPX8 ^@ http://purl.uniprot.org/uniprot/G3VQ14 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9305:RTCA ^@ http://purl.uniprot.org/uniprot/A0A7N4NH01 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/9305:SOST ^@ http://purl.uniprot.org/uniprot/A0A7N4P365 ^@ Function|||Similarity|||Subunit ^@ Belongs to the sclerostin family.|||Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.|||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. http://togogenome.org/gene/9305:CLIC3 ^@ http://purl.uniprot.org/uniprot/G3W4L4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9305:SLCO3A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P2J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100927965 ^@ http://purl.uniprot.org/uniprot/G3VVE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MTG1 ^@ http://purl.uniprot.org/uniprot/G3WBK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Mitochondrion inner membrane|||Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. http://togogenome.org/gene/9305:LNPEP ^@ http://purl.uniprot.org/uniprot/G3VCX1 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/9305:LOC100913809 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100913560 ^@ http://purl.uniprot.org/uniprot/G3VL41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9305:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PG89|||http://purl.uniprot.org/uniprot/G3W9S7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:CCR4 ^@ http://purl.uniprot.org/uniprot/A0A7N4V669|||http://purl.uniprot.org/uniprot/G3VFP3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYD9|||http://purl.uniprot.org/uniprot/G3WHW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9305:IRX4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9305:ADHFE1 ^@ http://purl.uniprot.org/uniprot/G3WDY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9305:ACSF3 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSE7|||http://purl.uniprot.org/uniprot/G3WHV6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9305:KIF1C ^@ http://purl.uniprot.org/uniprot/G3VFP0|||http://purl.uniprot.org/uniprot/G3VFP1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:SPSB2 ^@ http://purl.uniprot.org/uniprot/G3WU31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9305:XKR9 ^@ http://purl.uniprot.org/uniprot/G3WJB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9305:PYCR3 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1Q9 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9305:TMEM267 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100919512 ^@ http://purl.uniprot.org/uniprot/G3VNG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IDH1 ^@ http://purl.uniprot.org/uniprot/G3W9L8 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/9305:LOC100923276 ^@ http://purl.uniprot.org/uniprot/G3W9P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100928328 ^@ http://purl.uniprot.org/uniprot/G3WC14 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9305:IL1A ^@ http://purl.uniprot.org/uniprot/G3W2K5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Monomer.|||Nucleus|||Secreted http://togogenome.org/gene/9305:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/G3VS60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/9305:TGFB2 ^@ http://purl.uniprot.org/uniprot/G3WZB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9305:VPS35 ^@ http://purl.uniprot.org/uniprot/G3VK89 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9305:SLC16A11 ^@ http://purl.uniprot.org/uniprot/G3VDA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM00 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9305:PUS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0X0|||http://purl.uniprot.org/uniprot/G3WJ74 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9305:P2RX7 ^@ http://purl.uniprot.org/uniprot/G3WT47|||http://purl.uniprot.org/uniprot/G3WT48 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9305:CA7 ^@ http://purl.uniprot.org/uniprot/G3VKH8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9305:LOC100923659 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJJ8 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9305:RSPO1 ^@ http://purl.uniprot.org/uniprot/G3WGZ4 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9305:TMEM256 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9305:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NX18|||http://purl.uniprot.org/uniprot/G3W4W7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9305:FXN ^@ http://purl.uniprot.org/uniprot/A0A7N4NQC6 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/9305:PSMB6 ^@ http://purl.uniprot.org/uniprot/G3VIS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:STAT1 ^@ http://purl.uniprot.org/uniprot/G3WWX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:CYTB ^@ http://purl.uniprot.org/uniprot/G1FKD0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/9305:KIF22 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3B0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:LOC100921435 ^@ http://purl.uniprot.org/uniprot/A0A7N4PDJ3 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9305:ME3 ^@ http://purl.uniprot.org/uniprot/G3WCM1 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9305:FASLG ^@ http://purl.uniprot.org/uniprot/G3X251 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9305:ABCG4 ^@ http://purl.uniprot.org/uniprot/G3W6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9305:BOLA1 ^@ http://purl.uniprot.org/uniprot/G3VKU1 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9305:NR4A3 ^@ http://purl.uniprot.org/uniprot/G3WK77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9305:PSKH1 ^@ http://purl.uniprot.org/uniprot/G3VX66 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9305:NUP155 ^@ http://purl.uniprot.org/uniprot/G3WZE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9305:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNN6|||http://purl.uniprot.org/uniprot/G3WEN2 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9305:ABCG2 ^@ http://purl.uniprot.org/uniprot/G3VHT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Cell membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9305:LOC100917762 ^@ http://purl.uniprot.org/uniprot/A0A7N4NM45 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/9305:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWJ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pym family.|||Cytoplasm|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9305:MBOAT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHF1|||http://purl.uniprot.org/uniprot/G3WFK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPS0|||http://purl.uniprot.org/uniprot/G3VQW3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9305:INIP ^@ http://purl.uniprot.org/uniprot/A0A7N4PMB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9305:EVPL ^@ http://purl.uniprot.org/uniprot/G3WYM5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:PROK1 ^@ http://purl.uniprot.org/uniprot/G3WCA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9305:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/A0A7N4V5Z1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9305:DOLK ^@ http://purl.uniprot.org/uniprot/G3X3R8 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9305:ZRANB1 ^@ http://purl.uniprot.org/uniprot/G3VT52|||http://purl.uniprot.org/uniprot/G3VT53 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9305:LOC100924401 ^@ http://purl.uniprot.org/uniprot/G3W7Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100914330 ^@ http://purl.uniprot.org/uniprot/G3W4U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919695 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK16|||http://purl.uniprot.org/uniprot/G3WUU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A7N4PDV4 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9305:GET4 ^@ http://purl.uniprot.org/uniprot/G3WJG0 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/9305:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7C6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9305:LOC100914760 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FAH ^@ http://purl.uniprot.org/uniprot/G3WQ22 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9305:MRPL10 ^@ http://purl.uniprot.org/uniprot/A0A7N4NLV4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/9305:TCTE3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P0F4 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9305:ITGAL ^@ http://purl.uniprot.org/uniprot/A0A7N4UYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:LOC100932812 ^@ http://purl.uniprot.org/uniprot/G3WQ04 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:PWWP3A ^@ http://purl.uniprot.org/uniprot/G3WLW9 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9305:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P131 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9305:TBX20 ^@ http://purl.uniprot.org/uniprot/A0A7N4NW62 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:CNN1 ^@ http://purl.uniprot.org/uniprot/G3VQ33 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9305:IMPA2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHG5 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9305:DRAXIN ^@ http://purl.uniprot.org/uniprot/G3W7G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.|||Interacts with LRP6.|||Secreted http://togogenome.org/gene/9305:FABP2 ^@ http://purl.uniprot.org/uniprot/G3WB52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9305:FAM83D ^@ http://purl.uniprot.org/uniprot/G3WSA4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9305:LOC100925379 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:PROM2 ^@ http://purl.uniprot.org/uniprot/G3WAK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9305:MTMR8 ^@ http://purl.uniprot.org/uniprot/G3VDJ9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9305:MAK16 ^@ http://purl.uniprot.org/uniprot/G3W012 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9305:NME7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NRS5|||http://purl.uniprot.org/uniprot/G3VTT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9305:LOC100931126 ^@ http://purl.uniprot.org/uniprot/A0A7N4V048 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TDP1 ^@ http://purl.uniprot.org/uniprot/G3VQW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9305:NME5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PBN9 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9305:CGA ^@ http://purl.uniprot.org/uniprot/G3VYZ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted http://togogenome.org/gene/9305:NSUN2 ^@ http://purl.uniprot.org/uniprot/G3WBW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9305:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/G3WVR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9305:PSMA5 ^@ http://purl.uniprot.org/uniprot/G3X0Z9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9305:FSCN3 ^@ http://purl.uniprot.org/uniprot/G3WQP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9305:LOC100918041 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9305:LOC100920521 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:MOGAT2 ^@ http://purl.uniprot.org/uniprot/G3VDN0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:TSPAN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PHZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9305:AARS2 ^@ http://purl.uniprot.org/uniprot/G3WYZ7 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9305:TIMM17B ^@ http://purl.uniprot.org/uniprot/G3VEY9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:HS3ST1 ^@ http://purl.uniprot.org/uniprot/G3W857 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:SYNJ1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJ74 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9305:METTL15 ^@ http://purl.uniprot.org/uniprot/G3WTP3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9305:LOC100913284 ^@ http://purl.uniprot.org/uniprot/A0A7N4PWI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:FAHD2A ^@ http://purl.uniprot.org/uniprot/G3W4N2 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9305:NUTM1 ^@ http://purl.uniprot.org/uniprot/G3VMN0 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/9305:OPRD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100927993 ^@ http://purl.uniprot.org/uniprot/G3VLB7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9305:LOC100915011 ^@ http://purl.uniprot.org/uniprot/G3WM89 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:TEKT3 ^@ http://purl.uniprot.org/uniprot/G3WS64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9305:SDAD1 ^@ http://purl.uniprot.org/uniprot/G3VIU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9305:TM4SF20 ^@ http://purl.uniprot.org/uniprot/G3WF49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9305:IL1B ^@ http://purl.uniprot.org/uniprot/G3W4G1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9305:CHRNB4 ^@ http://purl.uniprot.org/uniprot/G3WY62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9305:RIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7X9|||http://purl.uniprot.org/uniprot/G3VXK2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the RIPOR family.|||Cell membrane|||Membrane|||cytoskeleton|||filopodium|||stereocilium membrane http://togogenome.org/gene/9305:LOC100917708 ^@ http://purl.uniprot.org/uniprot/G3VV00 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:FGF23 ^@ http://purl.uniprot.org/uniprot/A0A7N4PC55 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9305:GLRX ^@ http://purl.uniprot.org/uniprot/A0A7N4V0D0 ^@ Function ^@ Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9305:LOC100934244 ^@ http://purl.uniprot.org/uniprot/G3WWE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LITAF ^@ http://purl.uniprot.org/uniprot/A0A7N4NP27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9305:SLC35A1 ^@ http://purl.uniprot.org/uniprot/G3W9J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9305:ALG5 ^@ http://purl.uniprot.org/uniprot/G3VNR5 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9305:LYG1 ^@ http://purl.uniprot.org/uniprot/G3W6E3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9305:SNX7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYJ1|||http://purl.uniprot.org/uniprot/G3VI05 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9305:ATP2B3 ^@ http://purl.uniprot.org/uniprot/G3VTR7|||http://purl.uniprot.org/uniprot/G3VTR8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100917257 ^@ http://purl.uniprot.org/uniprot/A0A7N4NH53 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9305:GRPEL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PVP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9305:LOC100933766 ^@ http://purl.uniprot.org/uniprot/G3WMU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9305:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSS3|||http://purl.uniprot.org/uniprot/G3WZX7 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9305:ITPKB ^@ http://purl.uniprot.org/uniprot/A0A7N4P3K9 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9305:LOC100933226 ^@ http://purl.uniprot.org/uniprot/G3X1S0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9305:BHMT2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PFG4 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9305:MTRF1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PXV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9305:GPR158 ^@ http://purl.uniprot.org/uniprot/A0A7N4PYE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:AMZ1 ^@ http://purl.uniprot.org/uniprot/G3WH89 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9305:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXQ3|||http://purl.uniprot.org/uniprot/G3W6V6 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9305:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A7N4V6L7|||http://purl.uniprot.org/uniprot/G3WIE3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:ROR2 ^@ http://purl.uniprot.org/uniprot/A0A7N4P3Q4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:LOC100923899 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ESRRB ^@ http://purl.uniprot.org/uniprot/G3WKX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100916224 ^@ http://purl.uniprot.org/uniprot/A0A7N4V632 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:DPYSL2 ^@ http://purl.uniprot.org/uniprot/G3W2B2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.|||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. http://togogenome.org/gene/9305:LOC100913970 ^@ http://purl.uniprot.org/uniprot/G3W6F8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:S100A2 ^@ http://purl.uniprot.org/uniprot/G3W673 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9305:SNAPIN ^@ http://purl.uniprot.org/uniprot/A0A7N4PBC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/9305:NEUROD6 ^@ http://purl.uniprot.org/uniprot/G3W7F7 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9305:LOC100926505 ^@ http://purl.uniprot.org/uniprot/G3WI29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9305:PLCB2 ^@ http://purl.uniprot.org/uniprot/G3WJX3 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9305:DOHH ^@ http://purl.uniprot.org/uniprot/G3W423 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/9305:LOC100934629 ^@ http://purl.uniprot.org/uniprot/G3VHA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornifin (SPRR) family.|||Cytoplasm http://togogenome.org/gene/9305:LIAS ^@ http://purl.uniprot.org/uniprot/A0A7N4UYM0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/9305:CENPX ^@ http://purl.uniprot.org/uniprot/A0A7N4PA68 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/9305:LOC100926253 ^@ http://purl.uniprot.org/uniprot/G3VS86 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9305:IDH3G ^@ http://purl.uniprot.org/uniprot/G3VDI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9305:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A7N4P0S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9305:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A7N4UY26|||http://purl.uniprot.org/uniprot/G3WWB5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9305:IGFBP4 ^@ http://purl.uniprot.org/uniprot/G3WEN7 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:B3GALNT1 ^@ http://purl.uniprot.org/uniprot/G3WUQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:LOC100921066 ^@ http://purl.uniprot.org/uniprot/G3W3U8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:POGLUT2 ^@ http://purl.uniprot.org/uniprot/G3WF10 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9305:SCARB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NIW8 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9305:UBLCP1 ^@ http://purl.uniprot.org/uniprot/G3X3H9 ^@ Function|||Subcellular Location Annotation ^@ Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|||Nucleus http://togogenome.org/gene/9305:DIP2C ^@ http://purl.uniprot.org/uniprot/A0A7N4NKK4 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/9305:CRYGN ^@ http://purl.uniprot.org/uniprot/G3VJJ3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:LOC100927430 ^@ http://purl.uniprot.org/uniprot/G3VS03 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/9305:LOC100916712 ^@ http://purl.uniprot.org/uniprot/G3VA05 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:TPMT ^@ http://purl.uniprot.org/uniprot/A0A7N4PUT2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9305:INTS7 ^@ http://purl.uniprot.org/uniprot/G3VFT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9305:IKBKE ^@ http://purl.uniprot.org/uniprot/G3WZ29 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:LOC100919087 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9305:LOC100935414 ^@ http://purl.uniprot.org/uniprot/G3VXJ4 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9305:LOC100927633 ^@ http://purl.uniprot.org/uniprot/G3W7X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NOP14 ^@ http://purl.uniprot.org/uniprot/G3WBE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/9305:LOC100919998 ^@ http://purl.uniprot.org/uniprot/A0A7N4P9W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SPARC ^@ http://purl.uniprot.org/uniprot/G3VZ19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9305:APOH ^@ http://purl.uniprot.org/uniprot/G3VSZ3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9305:TDO2 ^@ http://purl.uniprot.org/uniprot/G3VJX9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:MBOAT4 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q1R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:COPB2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVA7|||http://purl.uniprot.org/uniprot/G3WCJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/9305:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/G3VUX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9305:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLT4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:DKC1 ^@ http://purl.uniprot.org/uniprot/G3VHY1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9305:LOC100924585 ^@ http://purl.uniprot.org/uniprot/G3WEN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:OLFM3 ^@ http://purl.uniprot.org/uniprot/G3WPL4 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9305:LRP12 ^@ http://purl.uniprot.org/uniprot/G3WK40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A7N4NMK6|||http://purl.uniprot.org/uniprot/G3WJZ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9305:EZR ^@ http://purl.uniprot.org/uniprot/G3W6E9 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9305:LYG2 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYT0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9305:LOC100928819 ^@ http://purl.uniprot.org/uniprot/A0A7N4PLI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9305:BCL2L1 ^@ http://purl.uniprot.org/uniprot/G3WKX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9305:SEPTIN9 ^@ http://purl.uniprot.org/uniprot/G3VWH9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9305:SLC37A4 ^@ http://purl.uniprot.org/uniprot/G3W9X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9305:DACT1 ^@ http://purl.uniprot.org/uniprot/G3X297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dapper family.|||Cytoplasm http://togogenome.org/gene/9305:PSMA3 ^@ http://purl.uniprot.org/uniprot/G3X0H5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9305:LOC100931976 ^@ http://purl.uniprot.org/uniprot/G3VFS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9305:DPM2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PM74 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9305:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A7N4V155|||http://purl.uniprot.org/uniprot/G3VP12 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9305:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A7N4NZQ8|||http://purl.uniprot.org/uniprot/G3W0A8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:LYPD6B ^@ http://purl.uniprot.org/uniprot/G3WG58 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:G6PC ^@ http://purl.uniprot.org/uniprot/A0A7N4PK76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9305:XKR5 ^@ http://purl.uniprot.org/uniprot/G3VG39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9305:MTRF1L ^@ http://purl.uniprot.org/uniprot/A0A7N4UX32|||http://purl.uniprot.org/uniprot/G3X0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9305:TNS4 ^@ http://purl.uniprot.org/uniprot/G3WCW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9305:CDC5L ^@ http://purl.uniprot.org/uniprot/G3WZE7 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/9305:CD5L ^@ http://purl.uniprot.org/uniprot/G3VVS4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:HAS2 ^@ http://purl.uniprot.org/uniprot/G3W3U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NodC/HAS family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane http://togogenome.org/gene/9305:TLR4 ^@ http://purl.uniprot.org/uniprot/G3WXY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9305:UVSSA ^@ http://purl.uniprot.org/uniprot/A0A7N4PQ44 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9305:HSF2 ^@ http://purl.uniprot.org/uniprot/G3WK53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9305:CCR7 ^@ http://purl.uniprot.org/uniprot/A0A7N4V6I9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:LOC100921536 ^@ http://purl.uniprot.org/uniprot/A0A7N4P178 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100930044 ^@ http://purl.uniprot.org/uniprot/G3X129|||http://purl.uniprot.org/uniprot/G3X1G8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9305:PTK2B ^@ http://purl.uniprot.org/uniprot/A0A7N4P5K2|||http://purl.uniprot.org/uniprot/G3VFW4 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9305:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NN41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9305:LOC100928021 ^@ http://purl.uniprot.org/uniprot/G3VPF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXZ5|||http://purl.uniprot.org/uniprot/G3VNQ0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9305:INSIG2 ^@ http://purl.uniprot.org/uniprot/G3X2R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9305:LOC100932623 ^@ http://purl.uniprot.org/uniprot/G3VZ13 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:CREB3L4 ^@ http://purl.uniprot.org/uniprot/G3WE97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:ANTXR2 ^@ http://purl.uniprot.org/uniprot/G3X1V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9305:LOC100921472 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXQ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100926652 ^@ http://purl.uniprot.org/uniprot/A0A7N4NVB3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9305:BYSL ^@ http://purl.uniprot.org/uniprot/G3VMU2 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9305:CDH7 ^@ http://purl.uniprot.org/uniprot/G3W7N1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NCAPH2 ^@ http://purl.uniprot.org/uniprot/G3VAL8 ^@ Similarity ^@ Belongs to the CND2 H2 (condensin-2 subunit 2) family. http://togogenome.org/gene/9305:LOC100929415 ^@ http://purl.uniprot.org/uniprot/G3VUZ8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PKS7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:PLA2G2D ^@ http://purl.uniprot.org/uniprot/G3WHN2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9305:CENPK ^@ http://purl.uniprot.org/uniprot/G3WDR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9305:CCNB1 ^@ http://purl.uniprot.org/uniprot/G3W0C2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9305:DCLRE1B ^@ http://purl.uniprot.org/uniprot/G3WJ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9305:TBCE ^@ http://purl.uniprot.org/uniprot/G3WPN9|||http://purl.uniprot.org/uniprot/G3WPP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/9305:TUBGCP5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PAT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9305:PLSCR3 ^@ http://purl.uniprot.org/uniprot/G3VTV2 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9305:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/G3W9V9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:CCDC39 ^@ http://purl.uniprot.org/uniprot/G3X264 ^@ Similarity ^@ Belongs to the CCDC39 family. http://togogenome.org/gene/9305:ATP5PD ^@ http://purl.uniprot.org/uniprot/G3X351 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:GAD2 ^@ http://purl.uniprot.org/uniprot/G3WJK8 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9305:MED31 ^@ http://purl.uniprot.org/uniprot/A0A7N4PIC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9305:HPS5 ^@ http://purl.uniprot.org/uniprot/G3WTX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/9305:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9305:HOXC11 ^@ http://purl.uniprot.org/uniprot/A0A7N4PF54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9305:KIF3B ^@ http://purl.uniprot.org/uniprot/A0A7N4PM20|||http://purl.uniprot.org/uniprot/G3WA27 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9305:LOC100923741 ^@ http://purl.uniprot.org/uniprot/A0A7N4NI86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/G3WHW8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9305:CLDN25 ^@ http://purl.uniprot.org/uniprot/G3WIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9305:SCNN1G ^@ http://purl.uniprot.org/uniprot/G3W678 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100923639 ^@ http://purl.uniprot.org/uniprot/A0A7N4NTK9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9305:LOC100917166 ^@ http://purl.uniprot.org/uniprot/G3VGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100933995 ^@ http://purl.uniprot.org/uniprot/G3WDK7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:PSD ^@ http://purl.uniprot.org/uniprot/G3X3K4|||http://purl.uniprot.org/uniprot/G3X3L2 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9305:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A7N4UYI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:TDP2 ^@ http://purl.uniprot.org/uniprot/A0A7N4NFI6 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9305:EDN2 ^@ http://purl.uniprot.org/uniprot/G3VTC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9305:GRN ^@ http://purl.uniprot.org/uniprot/G3WTW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9305:TSR1 ^@ http://purl.uniprot.org/uniprot/G3WD22 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9305:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PI17 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9305:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PD16|||http://purl.uniprot.org/uniprot/G3WN40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9305:SLC15A5 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUP9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/9305:TMBIM6 ^@ http://purl.uniprot.org/uniprot/A0A7N4NYB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9305:ANTXR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NL41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9305:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPI7|||http://purl.uniprot.org/uniprot/A0A7N4PTD1|||http://purl.uniprot.org/uniprot/G3X0Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/9305:LOC100916049 ^@ http://purl.uniprot.org/uniprot/A0A7N4V2K5|||http://purl.uniprot.org/uniprot/G3WPD7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:FRK ^@ http://purl.uniprot.org/uniprot/A0A7N4PBP1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:MRPS14 ^@ http://purl.uniprot.org/uniprot/A0A7N4V557 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9305:CLDN6 ^@ http://purl.uniprot.org/uniprot/G3WYY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:LOC100919646 ^@ http://purl.uniprot.org/uniprot/G3X2U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:MDFIC ^@ http://purl.uniprot.org/uniprot/A0A7N4NFP5 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9305:NR3C1 ^@ http://purl.uniprot.org/uniprot/G3VFI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/9305:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PCT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9305:MOCS1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX61 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/9305:THRSP ^@ http://purl.uniprot.org/uniprot/G3WIF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9305:EXT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P943 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.|||cis-Golgi network membrane http://togogenome.org/gene/9305:THRB ^@ http://purl.uniprot.org/uniprot/G3VNI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100927088 ^@ http://purl.uniprot.org/uniprot/G3VNX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:AOC1 ^@ http://purl.uniprot.org/uniprot/G3W0I7 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9305:PTGES ^@ http://purl.uniprot.org/uniprot/A0A7N4P8B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9305:RPS17 ^@ http://purl.uniprot.org/uniprot/G3WM06 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9305:FAM53A ^@ http://purl.uniprot.org/uniprot/G3WNK1 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9305:LOC100914020 ^@ http://purl.uniprot.org/uniprot/G3VQ51 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9305:ALOX5AP ^@ http://purl.uniprot.org/uniprot/G3WR31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:LOC100929420 ^@ http://purl.uniprot.org/uniprot/A0A7N4NKA8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9305:LOC105750956 ^@ http://purl.uniprot.org/uniprot/G3W669 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNW9 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9305:BORA ^@ http://purl.uniprot.org/uniprot/G3WQL8 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/9305:MIP ^@ http://purl.uniprot.org/uniprot/G3VI04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9305:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/G3W237|||http://purl.uniprot.org/uniprot/G3W238 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9305:ETFB ^@ http://purl.uniprot.org/uniprot/A0A7N4PCC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9305:HAPLN3 ^@ http://purl.uniprot.org/uniprot/G3WV87 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:PIANP ^@ http://purl.uniprot.org/uniprot/G3WRY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:TUT7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NMP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/9305:LOC100934777 ^@ http://purl.uniprot.org/uniprot/G3WBN1 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9305:LOC100921946 ^@ http://purl.uniprot.org/uniprot/A0A7N4NG24 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:GET3 ^@ http://purl.uniprot.org/uniprot/G3WSW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9305:TBCCD1 ^@ http://purl.uniprot.org/uniprot/G3W8E5|||http://purl.uniprot.org/uniprot/G3W8E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9305:LEAP2 ^@ http://purl.uniprot.org/uniprot/G3WJ22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9305:ITGA7 ^@ http://purl.uniprot.org/uniprot/A0A7N4NJ47|||http://purl.uniprot.org/uniprot/A0A7N4PUP2|||http://purl.uniprot.org/uniprot/G3W6Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9305:NOXA1 ^@ http://purl.uniprot.org/uniprot/G3WET3 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9305:RAMP3 ^@ http://purl.uniprot.org/uniprot/A0A7N4PMX1 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9305:B4GALNT1 ^@ http://purl.uniprot.org/uniprot/G3W2H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9305:PIGU ^@ http://purl.uniprot.org/uniprot/G3WZA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9305:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P8V8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:SEC61B ^@ http://purl.uniprot.org/uniprot/A0A7N4NT22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9305:ACTR1A ^@ http://purl.uniprot.org/uniprot/A0A7N4UZD5|||http://purl.uniprot.org/uniprot/G3X3J0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9305:GPAM ^@ http://purl.uniprot.org/uniprot/G3X2Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9305:CA4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NSE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-carbonic anhydrase family.|||Cell membrane|||Interacts with SLC4A4.|||Membrane|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9305:LOC100919803 ^@ http://purl.uniprot.org/uniprot/A0A7N4PSA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100920690 ^@ http://purl.uniprot.org/uniprot/G3VFQ0|||http://purl.uniprot.org/uniprot/G3VJ28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:APTX ^@ http://purl.uniprot.org/uniprot/A0A7N4P042 ^@ Subcellular Location Annotation ^@ nucleolus|||nucleoplasm http://togogenome.org/gene/9305:KCNH4 ^@ http://purl.uniprot.org/uniprot/G3VQL5 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9305:SNX2 ^@ http://purl.uniprot.org/uniprot/G3WI42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9305:APLP2 ^@ http://purl.uniprot.org/uniprot/G3VZN8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:FAM187A ^@ http://purl.uniprot.org/uniprot/G3W388 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9305:RBP7 ^@ http://purl.uniprot.org/uniprot/G3W8U3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9305:LOC100916439 ^@ http://purl.uniprot.org/uniprot/G3WNF4 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9305:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9305:LIN52 ^@ http://purl.uniprot.org/uniprot/A0A7N4P7H4 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/9305:CTSE ^@ http://purl.uniprot.org/uniprot/G3WWG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Endosome|||Homodimer; disulfide-linked.|||May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. http://togogenome.org/gene/9305:DPT ^@ http://purl.uniprot.org/uniprot/A0A7N4PPJ4|||http://purl.uniprot.org/uniprot/G3VE98 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9305:LOC100918565 ^@ http://purl.uniprot.org/uniprot/G3WIL7|||http://purl.uniprot.org/uniprot/G3WK08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC105748988 ^@ http://purl.uniprot.org/uniprot/G3VUU7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9305:LOC100918500 ^@ http://purl.uniprot.org/uniprot/G3VK62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100923647 ^@ http://purl.uniprot.org/uniprot/A0A7N4V1H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:JAK3 ^@ http://purl.uniprot.org/uniprot/G3VR92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/9305:MAP3K8 ^@ http://purl.uniprot.org/uniprot/G3VGB5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9305:LOC100929481 ^@ http://purl.uniprot.org/uniprot/M1ZMK8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9305:APPL2 ^@ http://purl.uniprot.org/uniprot/G3W7E7 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9305:SEMA4A ^@ http://purl.uniprot.org/uniprot/G3WLB2 ^@ Similarity ^@ Belongs to the semaphorin family. http://togogenome.org/gene/9305:CAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NT93|||http://purl.uniprot.org/uniprot/G3VF71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CAP family.|||Cell membrane|||Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.|||Homodimer. Binds actin monomers.|||Membrane http://togogenome.org/gene/9305:PARD6B ^@ http://purl.uniprot.org/uniprot/G3X3I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9305:NIBAN1 ^@ http://purl.uniprot.org/uniprot/G3VSI7 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9305:EDNRB ^@ http://purl.uniprot.org/uniprot/G3W138 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:IYD ^@ http://purl.uniprot.org/uniprot/G3VRG0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9305:WDR24 ^@ http://purl.uniprot.org/uniprot/G3WAT9 ^@ Similarity ^@ Belongs to the WD repeat WDR24 family. http://togogenome.org/gene/9305:LRRC51 ^@ http://purl.uniprot.org/uniprot/A0A7N4NS50|||http://purl.uniprot.org/uniprot/G3VJP9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:PLIN2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PR72|||http://purl.uniprot.org/uniprot/G3WPQ3 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9305:RPS2 ^@ http://purl.uniprot.org/uniprot/G3WR67 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. http://togogenome.org/gene/9305:SGMS2 ^@ http://purl.uniprot.org/uniprot/G3VXB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9305:FGFBP1 ^@ http://purl.uniprot.org/uniprot/G3X2B2 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9305:IL10 ^@ http://purl.uniprot.org/uniprot/G3X0Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9305:TAAR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V164 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9305:ATP1B2 ^@ http://purl.uniprot.org/uniprot/G3WS92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9305:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A7N4PN25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CCDC124 family.|||Interacts with RASGEF1B.|||Required for proper progression of late cytokinetic stages. http://togogenome.org/gene/9305:LOC100931482 ^@ http://purl.uniprot.org/uniprot/G3VC95 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100919505 ^@ http://purl.uniprot.org/uniprot/G3VWU8 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/9305:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P6X9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9305:COQ4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PUM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/9305:LOC100927115 ^@ http://purl.uniprot.org/uniprot/G3W6I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100917686 ^@ http://purl.uniprot.org/uniprot/G3VJW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:MARK3 ^@ http://purl.uniprot.org/uniprot/G3WVQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9305:TLCD3B ^@ http://purl.uniprot.org/uniprot/G3WA54|||http://purl.uniprot.org/uniprot/G3WA55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:SLC25A23 ^@ http://purl.uniprot.org/uniprot/A0A7N4V0I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:SLC35B3 ^@ http://purl.uniprot.org/uniprot/G3W616 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9305:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A7N4P5V9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/9305:LOC100934469 ^@ http://purl.uniprot.org/uniprot/A0A7N4NL37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ORC3 ^@ http://purl.uniprot.org/uniprot/G3WBD1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/9305:ESR2 ^@ http://purl.uniprot.org/uniprot/G3W1Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9305:LOC100914876 ^@ http://purl.uniprot.org/uniprot/A0A7N4PPB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:EVA1B ^@ http://purl.uniprot.org/uniprot/G3X0J8 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9305:DR1 ^@ http://purl.uniprot.org/uniprot/A0A7N4NWF1 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9305:GDF10 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXQ9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9305:LOC100923805 ^@ http://purl.uniprot.org/uniprot/G3WLA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9305:SCAMP1 ^@ http://purl.uniprot.org/uniprot/G3WX15|||http://purl.uniprot.org/uniprot/G3WX16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9305:FXR2 ^@ http://purl.uniprot.org/uniprot/G3WSR1 ^@ Similarity ^@ Belongs to the FMR1 family. http://togogenome.org/gene/9305:INTS12 ^@ http://purl.uniprot.org/uniprot/G3VLG8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.|||Nucleus http://togogenome.org/gene/9305:VPS33A ^@ http://purl.uniprot.org/uniprot/A0A7N4PDC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9305:BMP1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PL80|||http://purl.uniprot.org/uniprot/G3X157 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:MAPK4 ^@ http://purl.uniprot.org/uniprot/A0A7N4PRM6|||http://purl.uniprot.org/uniprot/G3WIM4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9305:RBP4 ^@ http://purl.uniprot.org/uniprot/G3WX74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/9305:FYN ^@ http://purl.uniprot.org/uniprot/A0A7N4PRT3|||http://purl.uniprot.org/uniprot/G3WAB1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9305:PSPN ^@ http://purl.uniprot.org/uniprot/A0A7N4NKR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9305:HEPH ^@ http://purl.uniprot.org/uniprot/A0A7N4NQH8|||http://purl.uniprot.org/uniprot/G3VFK7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9305:ZADH2 ^@ http://purl.uniprot.org/uniprot/G3WNM1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9305:S100A11 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHB5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9305:PLXNB2 ^@ http://purl.uniprot.org/uniprot/G3W8L6 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9305:LOC100914857 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q0X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:ANAPC4 ^@ http://purl.uniprot.org/uniprot/G3VL08 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9305:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A7N4P9J6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9305:SEC23B ^@ http://purl.uniprot.org/uniprot/A0A7N4PPN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9305:MET ^@ http://purl.uniprot.org/uniprot/G3WTF3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9305:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A7N4NZY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9305:AVPR1A ^@ http://purl.uniprot.org/uniprot/G3VT25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9305:MFSD4A ^@ http://purl.uniprot.org/uniprot/G3WRX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:YKT6 ^@ http://purl.uniprot.org/uniprot/G3WQE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9305:XPO5 ^@ http://purl.uniprot.org/uniprot/A0A7N4V720 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9305:FAM229B ^@ http://purl.uniprot.org/uniprot/G3WM14 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9305:LOC100916148 ^@ http://purl.uniprot.org/uniprot/A0A7N4NHJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100918225 ^@ http://purl.uniprot.org/uniprot/A0A7N4PX49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:COPS4 ^@ http://purl.uniprot.org/uniprot/G3W0X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9305:RPL23 ^@ http://purl.uniprot.org/uniprot/G3WXX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9305:PPIC ^@ http://purl.uniprot.org/uniprot/G3WBX0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9305:NLGN2 ^@ http://purl.uniprot.org/uniprot/G3VSL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:OLAH ^@ http://purl.uniprot.org/uniprot/G3WSI7 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/9305:LPO ^@ http://purl.uniprot.org/uniprot/G3WEN8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Secreted http://togogenome.org/gene/9305:PEX2 ^@ http://purl.uniprot.org/uniprot/G3WJD1 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/9305:LOC100930022 ^@ http://purl.uniprot.org/uniprot/G3WQ51 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9305:CMPK1 ^@ http://purl.uniprot.org/uniprot/G3W7E8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9305:GOT1L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4Q086|||http://purl.uniprot.org/uniprot/G3WWR3 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/9305:ND2 ^@ http://purl.uniprot.org/uniprot/G8XYV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9305:MC2R ^@ http://purl.uniprot.org/uniprot/G3WTM7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9305:NEUROD4 ^@ http://purl.uniprot.org/uniprot/G3W2H3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:OGFRL1 ^@ http://purl.uniprot.org/uniprot/G3WV34 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/9305:WNT6 ^@ http://purl.uniprot.org/uniprot/A0A7N4PZB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9305:NECAP1 ^@ http://purl.uniprot.org/uniprot/G3WXE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9305:SLC18B1 ^@ http://purl.uniprot.org/uniprot/G3W2Z7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:LOC100922750 ^@ http://purl.uniprot.org/uniprot/A0A7N4V543 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:TIMELESS ^@ http://purl.uniprot.org/uniprot/G3VBC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/9305:FAM187B ^@ http://purl.uniprot.org/uniprot/G3VIT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9305:TAT ^@ http://purl.uniprot.org/uniprot/G3VQD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9305:MAPRE2 ^@ http://purl.uniprot.org/uniprot/G3W6C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.|||cytoskeleton http://togogenome.org/gene/9305:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/A0A7N4PQX2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9305:GTPBP4 ^@ http://purl.uniprot.org/uniprot/G3WPF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9305:NPC1L1 ^@ http://purl.uniprot.org/uniprot/G3WVB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9305:LOC100930724 ^@ http://purl.uniprot.org/uniprot/G3VMZ7 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/9305:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A7N4PNR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9305:LOC100931615 ^@ http://purl.uniprot.org/uniprot/A0A7N4NXD3 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9305:MED30 ^@ http://purl.uniprot.org/uniprot/G3VQQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9305:MS4A3 ^@ http://purl.uniprot.org/uniprot/A0A7N4P056 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9305:LOC100929654 ^@ http://purl.uniprot.org/uniprot/G3WIX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:NIBAN3 ^@ http://purl.uniprot.org/uniprot/G3WF79 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9305:LOC100913340 ^@ http://purl.uniprot.org/uniprot/A0A7N4PA62 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9305:SPIN1 ^@ http://purl.uniprot.org/uniprot/A0A7N4V7Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/9305:GRPR ^@ http://purl.uniprot.org/uniprot/A0A7N4P155 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:LOC100916971 ^@ http://purl.uniprot.org/uniprot/G3VNK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9305:SOX14 ^@ http://purl.uniprot.org/uniprot/A0A7N4NK23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9305:TSC22D4 ^@ http://purl.uniprot.org/uniprot/A0A7N4NPT4 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9305:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A7N4P064 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9305:VTI1B ^@ http://purl.uniprot.org/uniprot/G3WFG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9305:NEUROD1 ^@ http://purl.uniprot.org/uniprot/A0A7N4UXL1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9305:RALB ^@ http://purl.uniprot.org/uniprot/G3WHN5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/9305:GLS2 ^@ http://purl.uniprot.org/uniprot/A0A7N4PJ20|||http://purl.uniprot.org/uniprot/G3VLF7 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9305:ELF2 ^@ http://purl.uniprot.org/uniprot/G3VIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9305:MPZ ^@ http://purl.uniprot.org/uniprot/A0A7N4NN84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the myelin P0 protein family.|||Cell membrane|||Homodimer and homotetramer.|||Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.|||Membrane http://togogenome.org/gene/9305:LOC100915970 ^@ http://purl.uniprot.org/uniprot/G3X2Z0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9305:ANXA6 ^@ http://purl.uniprot.org/uniprot/A0A7N4P1R5|||http://purl.uniprot.org/uniprot/A0A7N4PPX1|||http://purl.uniprot.org/uniprot/G3VF53 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome