http://togogenome.org/gene/9103:DUSP6 ^@ http://purl.uniprot.org/uniprot/G1NFD8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9103:MFSD8 ^@ http://purl.uniprot.org/uniprot/G1MZT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TIPARP ^@ http://purl.uniprot.org/uniprot/G1NE06 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9103:ARHGDIA ^@ http://purl.uniprot.org/uniprot/G1N1C7 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9103:SCARB2 ^@ http://purl.uniprot.org/uniprot/G1NBV6 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9103:LOC100546062 ^@ http://purl.uniprot.org/uniprot/G1MQB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9103:MYO1C ^@ http://purl.uniprot.org/uniprot/G1N0G6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:LOC100543381 ^@ http://purl.uniprot.org/uniprot/A0A803YDZ0|||http://purl.uniprot.org/uniprot/A0A803YQI8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9103:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A803Y5H9 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9103:LRRC8D ^@ http://purl.uniprot.org/uniprot/G1NR00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:POLR2D ^@ http://purl.uniprot.org/uniprot/G1MR77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9103:PIGC ^@ http://purl.uniprot.org/uniprot/A0A803YAR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9103:PTX3 ^@ http://purl.uniprot.org/uniprot/G1NDX8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100548322 ^@ http://purl.uniprot.org/uniprot/A0A803XY98 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:ACSL5 ^@ http://purl.uniprot.org/uniprot/G1NEL6 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/9103:CRYBB2 ^@ http://purl.uniprot.org/uniprot/G3URF3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9103:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/G1NGJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9103:LOC104911731 ^@ http://purl.uniprot.org/uniprot/A0A803YD04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A803YSS8 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/9103:EGFL7 ^@ http://purl.uniprot.org/uniprot/A0A803XQ99|||http://purl.uniprot.org/uniprot/G1N698 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A803XKI9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9103:LOC100545322 ^@ http://purl.uniprot.org/uniprot/G1NF62 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:SLU7 ^@ http://purl.uniprot.org/uniprot/G1MV97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9103:AARS1 ^@ http://purl.uniprot.org/uniprot/G1MTB6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9103:LOC100550995 ^@ http://purl.uniprot.org/uniprot/A0A803XKS4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:LOC100541373 ^@ http://purl.uniprot.org/uniprot/G1NR98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SYT2 ^@ http://purl.uniprot.org/uniprot/G1MS64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/9103:FAS ^@ http://purl.uniprot.org/uniprot/G1N8D3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9103:FTSJ3 ^@ http://purl.uniprot.org/uniprot/G1MQL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9103:KITLG ^@ http://purl.uniprot.org/uniprot/G1NFD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9103:CNOT2 ^@ http://purl.uniprot.org/uniprot/G1NDU7 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9103:PGM5 ^@ http://purl.uniprot.org/uniprot/G3UTT2 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9103:PFDN4 ^@ http://purl.uniprot.org/uniprot/G1NAK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9103:FAH ^@ http://purl.uniprot.org/uniprot/G1N8A1 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9103:GLOD4 ^@ http://purl.uniprot.org/uniprot/G1N587 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/9103:RBM17 ^@ http://purl.uniprot.org/uniprot/G1MXX8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/9103:ENO1 ^@ http://purl.uniprot.org/uniprot/A0A803YQS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9103:TDRD7 ^@ http://purl.uniprot.org/uniprot/G1N9C0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:ABCG4 ^@ http://purl.uniprot.org/uniprot/G1MUP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9103:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A803Y1F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9103:SCFD1 ^@ http://purl.uniprot.org/uniprot/G1NIF4 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9103:LAPTM4A ^@ http://purl.uniprot.org/uniprot/G1NMN1 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9103:TRAF5 ^@ http://purl.uniprot.org/uniprot/G1NBY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9103:ELOVL1 ^@ http://purl.uniprot.org/uniprot/G1NBS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9103:TMEM45A ^@ http://purl.uniprot.org/uniprot/G1NNH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9103:CHST9 ^@ http://purl.uniprot.org/uniprot/G1ND74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:FLNB ^@ http://purl.uniprot.org/uniprot/A0A803Y558|||http://purl.uniprot.org/uniprot/A0A803YJP2|||http://purl.uniprot.org/uniprot/G1N4G8|||http://purl.uniprot.org/uniprot/G3URL1 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9103:MAPK13 ^@ http://purl.uniprot.org/uniprot/G1MQ62 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9103:RSPO1 ^@ http://purl.uniprot.org/uniprot/G1MW47 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9103:CYGB ^@ http://purl.uniprot.org/uniprot/G1MYC6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A803XUX0|||http://purl.uniprot.org/uniprot/G1NDE4 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9103:PDE8A ^@ http://purl.uniprot.org/uniprot/G1N6Q3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:ABCC1 ^@ http://purl.uniprot.org/uniprot/A0A803YQX9|||http://purl.uniprot.org/uniprot/A0A803YRP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A803YFD6|||http://purl.uniprot.org/uniprot/A0A803YNP5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:RNF34 ^@ http://purl.uniprot.org/uniprot/G1MYN1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9103:CAPN8 ^@ http://purl.uniprot.org/uniprot/G1N8W2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:RPL26L1 ^@ http://purl.uniprot.org/uniprot/G1MWX8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9103:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A803YDE1|||http://purl.uniprot.org/uniprot/G1MXH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||dendrite|||filopodium|||growth cone|||sarcolemma http://togogenome.org/gene/9103:SLC12A8 ^@ http://purl.uniprot.org/uniprot/G1NHS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9103:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/G1NQF5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9103:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A803XMH9|||http://purl.uniprot.org/uniprot/G1NLR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9103:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A803Y4R3 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9103:WARS2 ^@ http://purl.uniprot.org/uniprot/A0A803XM46|||http://purl.uniprot.org/uniprot/G1NN51 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9103:LOC100545463 ^@ http://purl.uniprot.org/uniprot/G3UR23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:LMBR1 ^@ http://purl.uniprot.org/uniprot/G1N0G8 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9103:GPATCH1 ^@ http://purl.uniprot.org/uniprot/A0A803Y9Z2 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/9103:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A803XQ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/9103:SLC2A8 ^@ http://purl.uniprot.org/uniprot/G1N9B3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9103:SF3B5 ^@ http://purl.uniprot.org/uniprot/G1NRR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9103:CREB1 ^@ http://purl.uniprot.org/uniprot/G1N8F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CTNNA1 ^@ http://purl.uniprot.org/uniprot/G1MRP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||cytoskeleton http://togogenome.org/gene/9103:LOC104913713 ^@ http://purl.uniprot.org/uniprot/A0A803Y874 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:PPTC7 ^@ http://purl.uniprot.org/uniprot/G1N0F5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9103:LOC100539205 ^@ http://purl.uniprot.org/uniprot/G1N309 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9103:RPL29 ^@ http://purl.uniprot.org/uniprot/A0A803Y7F6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9103:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A803YS83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:PRL ^@ http://purl.uniprot.org/uniprot/E5RWR3|||http://purl.uniprot.org/uniprot/P17572 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted|||Three forms are found, non-glycosylated, glycosylated and one form seems to be only O-glycosylated. http://togogenome.org/gene/9103:CAPN5 ^@ http://purl.uniprot.org/uniprot/G1NQT4 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:LOC100303695 ^@ http://purl.uniprot.org/uniprot/Q91090 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated.|||Membrane|||The absence of paraoxonase activity in turkey and chicken blood and in turkey liver indicates that PON2, if expressed, does not hydrolyze paraoxon.|||The signal sequence is not cleaved. http://togogenome.org/gene/9103:SCT ^@ http://purl.uniprot.org/uniprot/G1MXA8 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9103:LOC100542828 ^@ http://purl.uniprot.org/uniprot/G1NPM8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9103:MELTF ^@ http://purl.uniprot.org/uniprot/G3UQM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/9103:CHD4 ^@ http://purl.uniprot.org/uniprot/G1NMS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9103:LOC100548537 ^@ http://purl.uniprot.org/uniprot/G3UPU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CD36 ^@ http://purl.uniprot.org/uniprot/G1N2C2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the CD36 family.|||Cell membrane|||Golgi apparatus|||Membrane|||Membrane raft http://togogenome.org/gene/9103:LOC100544886 ^@ http://purl.uniprot.org/uniprot/A0A803XSA4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9103:DDC ^@ http://purl.uniprot.org/uniprot/A0A803Y894|||http://purl.uniprot.org/uniprot/G1N437 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9103:HSF4 ^@ http://purl.uniprot.org/uniprot/G1MQD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9103:LOC104912110 ^@ http://purl.uniprot.org/uniprot/G3URH3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:RBFOX2 ^@ http://purl.uniprot.org/uniprot/G1NJB4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9103:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/G1NLP2 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9103:LYPLA2 ^@ http://purl.uniprot.org/uniprot/G1N1Z7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9103:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/G1MZ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9103:DCK ^@ http://purl.uniprot.org/uniprot/A0A803XPU9 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9103:LOC100551262 ^@ http://purl.uniprot.org/uniprot/A0A803Y725|||http://purl.uniprot.org/uniprot/G1NC34 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9103:NDUFA7 ^@ http://purl.uniprot.org/uniprot/A0A803Y5M6 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/9103:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A803YNT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9103:STAM2 ^@ http://purl.uniprot.org/uniprot/A0A803XP85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane http://togogenome.org/gene/9103:METTL15 ^@ http://purl.uniprot.org/uniprot/A0A803YIG7|||http://purl.uniprot.org/uniprot/G1MS79 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9103:UTP25 ^@ http://purl.uniprot.org/uniprot/A0A803YRU4|||http://purl.uniprot.org/uniprot/G1NM97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9103:RAD21 ^@ http://purl.uniprot.org/uniprot/G3URP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9103:LCA5 ^@ http://purl.uniprot.org/uniprot/A0A803XV60 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9103:SYNE3 ^@ http://purl.uniprot.org/uniprot/A0A803XN54 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9103:TBX15 ^@ http://purl.uniprot.org/uniprot/G1NN54 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:VGLL4 ^@ http://purl.uniprot.org/uniprot/G1N080 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9103:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A803YND8 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9103:CYP3A80 ^@ http://purl.uniprot.org/uniprot/Q1PCR2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:LOC100548433 ^@ http://purl.uniprot.org/uniprot/G1NN74 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:SSR1 ^@ http://purl.uniprot.org/uniprot/G1MXQ0|||http://purl.uniprot.org/uniprot/G5E7N7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9103:FARS2 ^@ http://purl.uniprot.org/uniprot/A0A803Y5Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/9103:SLC25A26 ^@ http://purl.uniprot.org/uniprot/G1NAJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:IL17B ^@ http://purl.uniprot.org/uniprot/A0A803XQS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9103:CCNE2 ^@ http://purl.uniprot.org/uniprot/G1NHN0 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/9103:TLR3 ^@ http://purl.uniprot.org/uniprot/G1NFY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9103:APOO ^@ http://purl.uniprot.org/uniprot/G1NP80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LSM3 ^@ http://purl.uniprot.org/uniprot/G1N6Z0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9103:STC1 ^@ http://purl.uniprot.org/uniprot/A0A803XW77|||http://purl.uniprot.org/uniprot/G1MR66 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9103:SV2B ^@ http://purl.uniprot.org/uniprot/G1N9R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9103:CPSF4 ^@ http://purl.uniprot.org/uniprot/G1MYH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9103:PTCH2 ^@ http://purl.uniprot.org/uniprot/G1NCW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9103:ARSJ ^@ http://purl.uniprot.org/uniprot/G1NEF9 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9103:SHQ1 ^@ http://purl.uniprot.org/uniprot/A0A803Y4M4 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/9103:RPS6KA6 ^@ http://purl.uniprot.org/uniprot/G1MZX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9103:NRF1 ^@ http://purl.uniprot.org/uniprot/G1MUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/9103:LOC100543119 ^@ http://purl.uniprot.org/uniprot/G1MXZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GPAT4 ^@ http://purl.uniprot.org/uniprot/G1MWM2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9103:LOC100550516 ^@ http://purl.uniprot.org/uniprot/G1N0P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9103:CUL4B ^@ http://purl.uniprot.org/uniprot/G1N6L9 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9103:DNAL4 ^@ http://purl.uniprot.org/uniprot/G1NL83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9103:LOC100551093 ^@ http://purl.uniprot.org/uniprot/G1NPB1 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9103:TMEM199 ^@ http://purl.uniprot.org/uniprot/A0A803YKW5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:SUPT6H ^@ http://purl.uniprot.org/uniprot/G1N2J9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9103:C1H12orf57 ^@ http://purl.uniprot.org/uniprot/G1NMW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9103:DOK3 ^@ http://purl.uniprot.org/uniprot/G1MY17 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9103:LOC109369088 ^@ http://purl.uniprot.org/uniprot/A0A803YJI0 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/9103:LOC100541482 ^@ http://purl.uniprot.org/uniprot/G1MQ38 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9103:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A803Y5M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9103:SEC16A ^@ http://purl.uniprot.org/uniprot/A0A803XQG8|||http://purl.uniprot.org/uniprot/A0A803YDU8|||http://purl.uniprot.org/uniprot/G1N6H6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9103:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A803Y4K1|||http://purl.uniprot.org/uniprot/G1NBP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9103:PNMT ^@ http://purl.uniprot.org/uniprot/A0A803YQ71 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9103:LOC100548086 ^@ http://purl.uniprot.org/uniprot/G1NDN1 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9103:LOC100542794 ^@ http://purl.uniprot.org/uniprot/G1MZ15 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9103:BCAT1 ^@ http://purl.uniprot.org/uniprot/G1NLL0 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9103:SFXN1 ^@ http://purl.uniprot.org/uniprot/G1MXQ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9103:VSNL1 ^@ http://purl.uniprot.org/uniprot/G1NMM0 ^@ Function ^@ Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. http://togogenome.org/gene/9103:STAC ^@ http://purl.uniprot.org/uniprot/A0A803XS17 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9103:TPM4 ^@ http://purl.uniprot.org/uniprot/G1N2D9|||http://purl.uniprot.org/uniprot/G3USL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9103:MPPED2 ^@ http://purl.uniprot.org/uniprot/G1MS47 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9103:LOC100547722 ^@ http://purl.uniprot.org/uniprot/G1NSA2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:STN1 ^@ http://purl.uniprot.org/uniprot/A0A803YGQ9|||http://purl.uniprot.org/uniprot/G1NDL9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9103:LOC100551192 ^@ http://purl.uniprot.org/uniprot/G1NND9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9103:RNF168 ^@ http://purl.uniprot.org/uniprot/G1MW43 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Nucleus|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs). http://togogenome.org/gene/9103:MYOD1 ^@ http://purl.uniprot.org/uniprot/Q6DV59 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9103:WARS1 ^@ http://purl.uniprot.org/uniprot/G1NKU2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9103:PPARD ^@ http://purl.uniprot.org/uniprot/G1N1X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:B4GALNT4 ^@ http://purl.uniprot.org/uniprot/A0A803XMU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/9103:OPRM1 ^@ http://purl.uniprot.org/uniprot/G1NJD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/9103:SPARC ^@ http://purl.uniprot.org/uniprot/G3UNZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9103:LOC100545437 ^@ http://purl.uniprot.org/uniprot/G1N570 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:PPP1R1C ^@ http://purl.uniprot.org/uniprot/G1NA38 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9103:AFF1 ^@ http://purl.uniprot.org/uniprot/G1N6P9 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9103:MASTL ^@ http://purl.uniprot.org/uniprot/G1N4L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Nucleus http://togogenome.org/gene/9103:MRAP ^@ http://purl.uniprot.org/uniprot/A0A803YLD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:BCL7B ^@ http://purl.uniprot.org/uniprot/G1MR22 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9103:ARPC3 ^@ http://purl.uniprot.org/uniprot/G1MXF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9103:DLD ^@ http://purl.uniprot.org/uniprot/G1NC58 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9103:ATP6V1D ^@ http://purl.uniprot.org/uniprot/G1NHD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9103:FGFBP1 ^@ http://purl.uniprot.org/uniprot/G1NJ28 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9103:DHX8 ^@ http://purl.uniprot.org/uniprot/G1MU21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:RPP30 ^@ http://purl.uniprot.org/uniprot/A0A803Y8Q4|||http://purl.uniprot.org/uniprot/G1N8L2 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9103:PSME4 ^@ http://purl.uniprot.org/uniprot/G1MUG7 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/9103:C6H7orf25 ^@ http://purl.uniprot.org/uniprot/G1NRV1 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9103:CLDN18 ^@ http://purl.uniprot.org/uniprot/G1MUI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:LOC100538454 ^@ http://purl.uniprot.org/uniprot/H9H278 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LRRC9 ^@ http://purl.uniprot.org/uniprot/G1NLG7 ^@ Similarity ^@ Belongs to the SDS22 family. http://togogenome.org/gene/9103:IL8 ^@ http://purl.uniprot.org/uniprot/A2VBZ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9103:KIF4A ^@ http://purl.uniprot.org/uniprot/G1MS31 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:NPB ^@ http://purl.uniprot.org/uniprot/A0A803XT58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropeptide B/W family.|||Secreted http://togogenome.org/gene/9103:LOC100546179 ^@ http://purl.uniprot.org/uniprot/G1NE73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MRE11 ^@ http://purl.uniprot.org/uniprot/G3UUL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9103:COPB1 ^@ http://purl.uniprot.org/uniprot/G1N4E1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9103:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A803YSQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9103:LOC100548208 ^@ http://purl.uniprot.org/uniprot/G1MXI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:SMAD2 ^@ http://purl.uniprot.org/uniprot/G1MRI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:LOC100541451 ^@ http://purl.uniprot.org/uniprot/G1MV25 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9103:HOXD12 ^@ http://purl.uniprot.org/uniprot/G1NBH7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:KAT6A ^@ http://purl.uniprot.org/uniprot/G1MW59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9103:REXO2 ^@ http://purl.uniprot.org/uniprot/G1MVK1 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9103:LOC104914778 ^@ http://purl.uniprot.org/uniprot/A0A803YRW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9103:KDM4A ^@ http://purl.uniprot.org/uniprot/G1NC21 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/9103:BRINP3 ^@ http://purl.uniprot.org/uniprot/G1MRI8 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9103:L3MBTL2 ^@ http://purl.uniprot.org/uniprot/G1NHY9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.|||Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. http://togogenome.org/gene/9103:CPM ^@ http://purl.uniprot.org/uniprot/G1NDL5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9103:NCAPG ^@ http://purl.uniprot.org/uniprot/G1NIX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9103:ZP4 ^@ http://purl.uniprot.org/uniprot/G1N505 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9103:MPEG1 ^@ http://purl.uniprot.org/uniprot/G1NRN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9103:ODC1 ^@ http://purl.uniprot.org/uniprot/G1NMK7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9103:LOC100540751 ^@ http://purl.uniprot.org/uniprot/A0A803Y629 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9103:RHBDF2 ^@ http://purl.uniprot.org/uniprot/G1MYF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/9103:S100B ^@ http://purl.uniprot.org/uniprot/G1MRY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. http://togogenome.org/gene/9103:COL4A1 ^@ http://purl.uniprot.org/uniprot/A0A803YH11 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9103:PLOD1 ^@ http://purl.uniprot.org/uniprot/G1N380 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9103:ODF2 ^@ http://purl.uniprot.org/uniprot/G1MYV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9103:GPSM2 ^@ http://purl.uniprot.org/uniprot/A0A803Y4Z6|||http://purl.uniprot.org/uniprot/G1N329 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9103:BMS1 ^@ http://purl.uniprot.org/uniprot/G1MRC6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9103:DDX47 ^@ http://purl.uniprot.org/uniprot/G1NH23 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9103:IL2RB ^@ http://purl.uniprot.org/uniprot/G1NJ37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/9103:AGPAT3 ^@ http://purl.uniprot.org/uniprot/G1NP28 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9103:PAIP2 ^@ http://purl.uniprot.org/uniprot/G1MRE8 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9103:CAPN11 ^@ http://purl.uniprot.org/uniprot/G1NEF6 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:ORMDL2 ^@ http://purl.uniprot.org/uniprot/G1N636 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9103:HDAC7 ^@ http://purl.uniprot.org/uniprot/A0A803YKY5|||http://purl.uniprot.org/uniprot/H9H1R9|||http://purl.uniprot.org/uniprot/H9H296 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9103:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A803XPK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9103:LOC100551000 ^@ http://purl.uniprot.org/uniprot/G1NGC4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9103:GABPA ^@ http://purl.uniprot.org/uniprot/G1NNT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:PPP2R5E ^@ http://purl.uniprot.org/uniprot/G1NLC0 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/9103:SPARCL1 ^@ http://purl.uniprot.org/uniprot/G1N6G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPARC family.|||extracellular matrix http://togogenome.org/gene/9103:PABPC1L ^@ http://purl.uniprot.org/uniprot/G1MXJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9103:VANGL2 ^@ http://purl.uniprot.org/uniprot/A0A803YAX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:OSTC ^@ http://purl.uniprot.org/uniprot/G3X8M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9103:WNT7B ^@ http://purl.uniprot.org/uniprot/G1NM45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9103:GRPR ^@ http://purl.uniprot.org/uniprot/G1NPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MED30 ^@ http://purl.uniprot.org/uniprot/G1NIP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9103:PHB ^@ http://purl.uniprot.org/uniprot/G1MU38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100550755 ^@ http://purl.uniprot.org/uniprot/A0A803YMN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:TMEM263 ^@ http://purl.uniprot.org/uniprot/G1NJM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9103:PARL ^@ http://purl.uniprot.org/uniprot/G1MQB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100548941 ^@ http://purl.uniprot.org/uniprot/A0A803XR11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100539006 ^@ http://purl.uniprot.org/uniprot/G1N9H8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:CXXC5 ^@ http://purl.uniprot.org/uniprot/G1MVL5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:SYT1 ^@ http://purl.uniprot.org/uniprot/G1NET9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/9103:RPS21 ^@ http://purl.uniprot.org/uniprot/G1N222 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9103:DDX1 ^@ http://purl.uniprot.org/uniprot/G1NML8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule http://togogenome.org/gene/9103:LOC100546242 ^@ http://purl.uniprot.org/uniprot/G1MYV1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:LOC100548260 ^@ http://purl.uniprot.org/uniprot/G3URB6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:NSMCE2 ^@ http://purl.uniprot.org/uniprot/G1NJ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9103:SLC39A3 ^@ http://purl.uniprot.org/uniprot/G1MYS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PAPPA ^@ http://purl.uniprot.org/uniprot/G1MVW6 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:NR3C2 ^@ http://purl.uniprot.org/uniprot/G1MY32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:POLR2J ^@ http://purl.uniprot.org/uniprot/G1MWS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9103:PDLIM3 ^@ http://purl.uniprot.org/uniprot/G3UQT4 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9103:TAF12 ^@ http://purl.uniprot.org/uniprot/G1MSE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9103:LOC100548279 ^@ http://purl.uniprot.org/uniprot/G1NN73 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:UBE3A ^@ http://purl.uniprot.org/uniprot/G1NPJ3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9103:SGCD ^@ http://purl.uniprot.org/uniprot/A0A803YRL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9103:GRK7 ^@ http://purl.uniprot.org/uniprot/G1N369 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9103:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A3RLM9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9103:HS3ST5 ^@ http://purl.uniprot.org/uniprot/G1NL03 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:GUK1 ^@ http://purl.uniprot.org/uniprot/G1MUI4 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9103:LOC104911958 ^@ http://purl.uniprot.org/uniprot/G1N722 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9103:LOC100542258 ^@ http://purl.uniprot.org/uniprot/H9H247 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9103:PDK4 ^@ http://purl.uniprot.org/uniprot/G1NBG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9103:SKAP1 ^@ http://purl.uniprot.org/uniprot/A0A803Y384|||http://purl.uniprot.org/uniprot/A0A803YC35 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9103:CD40 ^@ http://purl.uniprot.org/uniprot/A0A803Y327 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:CLVS2 ^@ http://purl.uniprot.org/uniprot/G1NKR8 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9103:LOC100547975 ^@ http://purl.uniprot.org/uniprot/A0A803YSA1 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9103:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A803Y4N3|||http://purl.uniprot.org/uniprot/A0A803YJ92|||http://purl.uniprot.org/uniprot/G3US55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9103:APOA4 ^@ http://purl.uniprot.org/uniprot/G1MVV8 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9103:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A803XM24|||http://purl.uniprot.org/uniprot/G1N450 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9103:ATP1B4 ^@ http://purl.uniprot.org/uniprot/G1N6Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9103:ULK3 ^@ http://purl.uniprot.org/uniprot/G1MU05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:LOC100541944 ^@ http://purl.uniprot.org/uniprot/A0A803XLW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9103:YDJC ^@ http://purl.uniprot.org/uniprot/G1MQK9 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9103:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A803XMU3|||http://purl.uniprot.org/uniprot/G1N465 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9103:COPS4 ^@ http://purl.uniprot.org/uniprot/G1N797 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9103:CHMP5 ^@ http://purl.uniprot.org/uniprot/G1N500 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9103:LPCAT1 ^@ http://purl.uniprot.org/uniprot/G1N5M4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9103:HOXD4 ^@ http://purl.uniprot.org/uniprot/G1NRU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9103:ND4 ^@ http://purl.uniprot.org/uniprot/A9XBE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9103:PDCD5 ^@ http://purl.uniprot.org/uniprot/G1N1P5 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9103:PURG ^@ http://purl.uniprot.org/uniprot/A0A803YN97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9103:ADRA1D ^@ http://purl.uniprot.org/uniprot/G1NKI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/9103:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A803XPP2|||http://purl.uniprot.org/uniprot/G1MVU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9103:APLN ^@ http://purl.uniprot.org/uniprot/A0A803XUU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apelin family.|||extracellular space http://togogenome.org/gene/9103:MED13L ^@ http://purl.uniprot.org/uniprot/G1NCE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9103:ARL6IP4 ^@ http://purl.uniprot.org/uniprot/G1MWR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL6IP4 family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9103:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/G1NBH9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:SAMM50 ^@ http://purl.uniprot.org/uniprot/G1NM02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9103:NKX6-3 ^@ http://purl.uniprot.org/uniprot/G1MWJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:APOLD1 ^@ http://purl.uniprot.org/uniprot/G1NRJ2 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9103:ENTPD3 ^@ http://purl.uniprot.org/uniprot/G1NFL8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9103:ESR2 ^@ http://purl.uniprot.org/uniprot/G1NLA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9103:CASP3 ^@ http://purl.uniprot.org/uniprot/G1N3N5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9103:LOC100545254 ^@ http://purl.uniprot.org/uniprot/A0A803YRD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9103:ESD ^@ http://purl.uniprot.org/uniprot/G1NQ47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9103:FXYD6 ^@ http://purl.uniprot.org/uniprot/A0A803Y0C3 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9103:NAP1L1 ^@ http://purl.uniprot.org/uniprot/G1NEH5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9103:APOD ^@ http://purl.uniprot.org/uniprot/G1N591 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9103:ATP1B1 ^@ http://purl.uniprot.org/uniprot/G1NNF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Cell membrane|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9103:GBF1 ^@ http://purl.uniprot.org/uniprot/G1N5L0 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9103:LOC100540040 ^@ http://purl.uniprot.org/uniprot/G1N453 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:TTC21B ^@ http://purl.uniprot.org/uniprot/G1NE60|||http://purl.uniprot.org/uniprot/G3UPS4 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9103:USP37 ^@ http://purl.uniprot.org/uniprot/G1NG28 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9103:GAPDH ^@ http://purl.uniprot.org/uniprot/C7DR02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.|||Homotetramer.|||cytosol http://togogenome.org/gene/9103:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A803XMX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9103:HADH ^@ http://purl.uniprot.org/uniprot/G1N2B6 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9103:LOC100546474 ^@ http://purl.uniprot.org/uniprot/A0A803YPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9103:COMT ^@ http://purl.uniprot.org/uniprot/G1MRP1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. http://togogenome.org/gene/9103:ETS2 ^@ http://purl.uniprot.org/uniprot/G1NNZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9103:LOC100538374 ^@ http://purl.uniprot.org/uniprot/G1MVF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9103:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A803YB95 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9103:HMGB3 ^@ http://purl.uniprot.org/uniprot/G1N7N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9103:PSKH1 ^@ http://purl.uniprot.org/uniprot/G1MUL2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:NXT2 ^@ http://purl.uniprot.org/uniprot/A0A803YCA1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9103:CHRM4 ^@ http://purl.uniprot.org/uniprot/G1NRP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9103:DTD2 ^@ http://purl.uniprot.org/uniprot/G1NIJ5 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9103:CRYBB1 ^@ http://purl.uniprot.org/uniprot/G1N4W0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9103:INTS14 ^@ http://purl.uniprot.org/uniprot/G1NBL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9103:NAE1 ^@ http://purl.uniprot.org/uniprot/G1N3N7 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/9103:SERPINB14 ^@ http://purl.uniprot.org/uniprot/G1MYL1|||http://purl.uniprot.org/uniprot/O73860 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the serpin family.|||Belongs to the serpin family. Ov-serpin subfamily.|||Major protein of egg white.|||Secreted|||Storage protein of egg white. Lack protease inhibitory activity (By similarity).|||The signal sequence is not cleaved. The functional signal for membrane translocation of ovalbumin becomes accessible when the nascent chain is 50 to 60 residues long. The hydrophobic sequence which lies between residues 27 and 43 folds back on the preceding residues to form an amphipathic hairpin structure which is the signal element recognized by the membrane (By similarity). http://togogenome.org/gene/9103:LOC100550464 ^@ http://purl.uniprot.org/uniprot/G1MX38 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9103:KCTD3 ^@ http://purl.uniprot.org/uniprot/G1NB57 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/9103:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/G1NEA9 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9103:LOC100541378 ^@ http://purl.uniprot.org/uniprot/G1NAK9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:FAM102A ^@ http://purl.uniprot.org/uniprot/G1MWZ5 ^@ Similarity ^@ Belongs to the FAM102 family. http://togogenome.org/gene/9103:NEUROD6 ^@ http://purl.uniprot.org/uniprot/G1NHS8 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9103:EIF3E ^@ http://purl.uniprot.org/uniprot/G1NIH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CTLA4 ^@ http://purl.uniprot.org/uniprot/G1N9D2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9103:UNC93A ^@ http://purl.uniprot.org/uniprot/G1NJJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9103:TUBGCP2 ^@ http://purl.uniprot.org/uniprot/G1MST2|||http://purl.uniprot.org/uniprot/G3UTW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9103:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A803YCE3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CREBL2 ^@ http://purl.uniprot.org/uniprot/G1NKP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9103:SEPTIN10 ^@ http://purl.uniprot.org/uniprot/A0A803XWV6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9103:UBE2T ^@ http://purl.uniprot.org/uniprot/G1N182 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:PACSIN2 ^@ http://purl.uniprot.org/uniprot/G1NLV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9103:BMP7 ^@ http://purl.uniprot.org/uniprot/A0A803XLM3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9103:LOC100544543 ^@ http://purl.uniprot.org/uniprot/G1MTE9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9103:DOCK11 ^@ http://purl.uniprot.org/uniprot/A0A803XVX7 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9103:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/G1NB00 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9103:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A803YN37|||http://purl.uniprot.org/uniprot/G1MVE4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:AASS ^@ http://purl.uniprot.org/uniprot/G1N8V9 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9103:LOC100549829 ^@ http://purl.uniprot.org/uniprot/G1NHW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9103:CDH11 ^@ http://purl.uniprot.org/uniprot/G1N438 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100538789 ^@ http://purl.uniprot.org/uniprot/G1NQY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100541107 ^@ http://purl.uniprot.org/uniprot/G1N3C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9103:LPCAT2 ^@ http://purl.uniprot.org/uniprot/G1MYQ2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9103:TGFA ^@ http://purl.uniprot.org/uniprot/H9H1B9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:DEGS1 ^@ http://purl.uniprot.org/uniprot/G1N889 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.|||Membrane http://togogenome.org/gene/9103:ORC2 ^@ http://purl.uniprot.org/uniprot/G1N6W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9103:EXOC7 ^@ http://purl.uniprot.org/uniprot/G1MYP9 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9103:SMIM12 ^@ http://purl.uniprot.org/uniprot/G1NRI8 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9103:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A803XYS0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A803Y5Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9103:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A803XUF9 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9103:NARF ^@ http://purl.uniprot.org/uniprot/G1MXE6 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9103:ELOVL5 ^@ http://purl.uniprot.org/uniprot/D4N2R0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/9103:SEMA5A ^@ http://purl.uniprot.org/uniprot/A0A803XW49|||http://purl.uniprot.org/uniprot/G1N3B5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:TMEM132A ^@ http://purl.uniprot.org/uniprot/G1MVW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/9103:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A803XSN6|||http://purl.uniprot.org/uniprot/A0A803YDQ1|||http://purl.uniprot.org/uniprot/G1NA27 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:RHBDF1 ^@ http://purl.uniprot.org/uniprot/A0A803XKG9|||http://purl.uniprot.org/uniprot/G1N9A9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/9103:LOC100538588 ^@ http://purl.uniprot.org/uniprot/G1NE87 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:BUD31 ^@ http://purl.uniprot.org/uniprot/G1MYF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9103:CCK ^@ http://purl.uniprot.org/uniprot/A0A803YKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9103:ATG4C ^@ http://purl.uniprot.org/uniprot/G1NGS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9103:CCDC47 ^@ http://purl.uniprot.org/uniprot/G1MSL1 ^@ Subcellular Location Annotation ^@ Membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9103:SFXN2 ^@ http://purl.uniprot.org/uniprot/G1ND51 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9103:LOC100544279 ^@ http://purl.uniprot.org/uniprot/G1NKE9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:TEKT1 ^@ http://purl.uniprot.org/uniprot/G1N9H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/9103:PUF60 ^@ http://purl.uniprot.org/uniprot/G1NK67|||http://purl.uniprot.org/uniprot/G3URA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9103:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A803XR49|||http://purl.uniprot.org/uniprot/G1MWH7 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9103:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/G1NIA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9103:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A803XN38 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9103:KIF23 ^@ http://purl.uniprot.org/uniprot/A0A803YA13|||http://purl.uniprot.org/uniprot/G5E7T7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/G1MWU9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9103:LOC100539364 ^@ http://purl.uniprot.org/uniprot/G1NHF5 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9103:UMPS ^@ http://purl.uniprot.org/uniprot/G1NHQ5 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9103:C17H12orf65 ^@ http://purl.uniprot.org/uniprot/G1MWC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9103:GPC1 ^@ http://purl.uniprot.org/uniprot/Q6QA54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate.|||extracellular space http://togogenome.org/gene/9103:SPOUT1 ^@ http://purl.uniprot.org/uniprot/G1MZD7 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9103:ACVR2A ^@ http://purl.uniprot.org/uniprot/G3UQ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9103:PSEN1 ^@ http://purl.uniprot.org/uniprot/G1NGN7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9103:ALG12 ^@ http://purl.uniprot.org/uniprot/G1N731 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.|||Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:LOC109363683 ^@ http://purl.uniprot.org/uniprot/G1NRL0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:LOC100540180 ^@ http://purl.uniprot.org/uniprot/A0A803XSJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/9103:LOC100541961 ^@ http://purl.uniprot.org/uniprot/A0A803XZR2 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9103:LOC100545215 ^@ http://purl.uniprot.org/uniprot/G1NH21 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Photoreceptor inner segment|||Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. http://togogenome.org/gene/9103:MNAT1 ^@ http://purl.uniprot.org/uniprot/G1NLE9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9103:TARDBP ^@ http://purl.uniprot.org/uniprot/G1MZJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:KATNA1 ^@ http://purl.uniprot.org/uniprot/G1NJ12 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9103:LOC100540676 ^@ http://purl.uniprot.org/uniprot/A0A803YR76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/9103:TMOD1 ^@ http://purl.uniprot.org/uniprot/G3UTY3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9103:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A803YMC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9103:NDFIP2 ^@ http://purl.uniprot.org/uniprot/A0A803Y697 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:DUOX2 ^@ http://purl.uniprot.org/uniprot/G1MQU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9103:LOC100548529 ^@ http://purl.uniprot.org/uniprot/G5E7W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9103:LOC104913878 ^@ http://purl.uniprot.org/uniprot/A0A803Y2J4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9103:NCAPH ^@ http://purl.uniprot.org/uniprot/G1ND91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9103:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A803YLK2 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9103:CPQ ^@ http://purl.uniprot.org/uniprot/G1NHR0 ^@ Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome|||Secreted http://togogenome.org/gene/9103:PRKAA2 ^@ http://purl.uniprot.org/uniprot/A1E4B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Cytoplasm http://togogenome.org/gene/9103:EHF ^@ http://purl.uniprot.org/uniprot/G1NCY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/G1NLX8 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9103:LOC100544289 ^@ http://purl.uniprot.org/uniprot/G1NGU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9103:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A803XVG0|||http://purl.uniprot.org/uniprot/G1ND89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9103:RHBDD2 ^@ http://purl.uniprot.org/uniprot/G1MXJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC104911466 ^@ http://purl.uniprot.org/uniprot/A0A803XPT8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9103:OLFM3 ^@ http://purl.uniprot.org/uniprot/G1N4M6 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9103:LOC104912586 ^@ http://purl.uniprot.org/uniprot/A0A803XN85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9103:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A803YNQ0|||http://purl.uniprot.org/uniprot/G1MT38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9103:GEM ^@ http://purl.uniprot.org/uniprot/G1NHG3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9103:LOC100550262 ^@ http://purl.uniprot.org/uniprot/G1MUR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9103:LPAR5 ^@ http://purl.uniprot.org/uniprot/G1NMT1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:NSUN3 ^@ http://purl.uniprot.org/uniprot/G1NNM1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9103:CNDP2 ^@ http://purl.uniprot.org/uniprot/G1N7Z4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9103:CRIPT ^@ http://purl.uniprot.org/uniprot/A0A803YBI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9103:CHRD ^@ http://purl.uniprot.org/uniprot/G1NBK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chordin family.|||Secreted http://togogenome.org/gene/9103:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A803XLP4 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9103:HTR1F ^@ http://purl.uniprot.org/uniprot/G1NS48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9103:LOC100548663 ^@ http://purl.uniprot.org/uniprot/G1NR57 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:APOA1 ^@ http://purl.uniprot.org/uniprot/G1MVX1 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9103:FSHB ^@ http://purl.uniprot.org/uniprot/G1MS74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9103:FAM110D ^@ http://purl.uniprot.org/uniprot/G1MUF3 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9103:LOC100546811 ^@ http://purl.uniprot.org/uniprot/G1N1J2 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/9103:LOC100546153 ^@ http://purl.uniprot.org/uniprot/A0A803XZ67 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9103:MOCOS ^@ http://purl.uniprot.org/uniprot/G1N4P3 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/9103:KCNA4 ^@ http://purl.uniprot.org/uniprot/A0A803YRL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.|||Cell membrane|||Membrane|||axon http://togogenome.org/gene/9103:AMZ1 ^@ http://purl.uniprot.org/uniprot/G1MVC9 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9103:PPP2R5C ^@ http://purl.uniprot.org/uniprot/G1NKU8 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/9103:OTOP2 ^@ http://purl.uniprot.org/uniprot/G1NAJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GDAP2 ^@ http://purl.uniprot.org/uniprot/G1NN58 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/9103:CD180 ^@ http://purl.uniprot.org/uniprot/G1MZA6 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/9103:RSRP1 ^@ http://purl.uniprot.org/uniprot/G1MT28 ^@ Similarity ^@ Belongs to the RSRP family. http://togogenome.org/gene/9103:OLAH ^@ http://purl.uniprot.org/uniprot/G1N829 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/9103:LOC104913500 ^@ http://purl.uniprot.org/uniprot/G1MUW0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:C2H6orf120 ^@ http://purl.uniprot.org/uniprot/G1NRR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||Secreted http://togogenome.org/gene/9103:AKT1 ^@ http://purl.uniprot.org/uniprot/G1NL49 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9103:NIPA2 ^@ http://purl.uniprot.org/uniprot/G1NPI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9103:MFAP3L ^@ http://purl.uniprot.org/uniprot/G1MU95 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:TMEM242 ^@ http://purl.uniprot.org/uniprot/G1NJI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9103:SSR2 ^@ http://purl.uniprot.org/uniprot/G1MQG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9103:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A803XYV6|||http://purl.uniprot.org/uniprot/A0A803YQL7|||http://purl.uniprot.org/uniprot/G1NBU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/9103:FAM160B1 ^@ http://purl.uniprot.org/uniprot/A0A803XS78 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9103:TRPV1 ^@ http://purl.uniprot.org/uniprot/G1N4J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendritic spine membrane http://togogenome.org/gene/9103:LOC100550023 ^@ http://purl.uniprot.org/uniprot/G1NK02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9103:APOA5 ^@ http://purl.uniprot.org/uniprot/G1MVT5 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9103:CPB1 ^@ http://purl.uniprot.org/uniprot/G1N4I9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9103:RER1 ^@ http://purl.uniprot.org/uniprot/G1MTJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9103:GALR1 ^@ http://purl.uniprot.org/uniprot/G1N7I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:PDCD4 ^@ http://purl.uniprot.org/uniprot/G1NEE4 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9103:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A803Y8S2|||http://purl.uniprot.org/uniprot/G1NDC3|||http://purl.uniprot.org/uniprot/G1NDC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9103:CFI ^@ http://purl.uniprot.org/uniprot/G1NEZ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:INS ^@ http://purl.uniprot.org/uniprot/G1N7C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/9103:FKTN ^@ http://purl.uniprot.org/uniprot/G1N6X1 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/9103:SLC13A2 ^@ http://purl.uniprot.org/uniprot/G1N241 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9103:MYF6 ^@ http://purl.uniprot.org/uniprot/D2KKK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CBL ^@ http://purl.uniprot.org/uniprot/G1MU46 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9103:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A803Y389|||http://purl.uniprot.org/uniprot/G1MYM9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9103:RPL13 ^@ http://purl.uniprot.org/uniprot/G1N7K0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9103:POLR2F ^@ http://purl.uniprot.org/uniprot/G1NIR0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9103:ELF3 ^@ http://purl.uniprot.org/uniprot/A0A803XY61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:PSMA1 ^@ http://purl.uniprot.org/uniprot/G1N4G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Nucleus http://togogenome.org/gene/9103:BET1L ^@ http://purl.uniprot.org/uniprot/G1MUQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SFMBT2 ^@ http://purl.uniprot.org/uniprot/G1MYG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CHRNA9 ^@ http://purl.uniprot.org/uniprot/G1NI10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:NCOR2 ^@ http://purl.uniprot.org/uniprot/G3US98 ^@ Similarity ^@ Belongs to the N-CoR nuclear receptor corepressors family. http://togogenome.org/gene/9103:TMTC3 ^@ http://purl.uniprot.org/uniprot/A0A803XYP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9103:CZIB ^@ http://purl.uniprot.org/uniprot/G1NFI6 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9103:OGN ^@ http://purl.uniprot.org/uniprot/G1MZ49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.|||extracellular matrix http://togogenome.org/gene/9103:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/A0A803Y6J6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:LOC104909874 ^@ http://purl.uniprot.org/uniprot/G1NLD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CTSK ^@ http://purl.uniprot.org/uniprot/G3X8J6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9103:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A803YL84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9103:TBX20 ^@ http://purl.uniprot.org/uniprot/G1NHI6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:LOC100543754 ^@ http://purl.uniprot.org/uniprot/A0A803YIS5|||http://purl.uniprot.org/uniprot/G1NP55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100539493 ^@ http://purl.uniprot.org/uniprot/A0A803XR55|||http://purl.uniprot.org/uniprot/G1NEJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Microsome membrane http://togogenome.org/gene/9103:NTNG2 ^@ http://purl.uniprot.org/uniprot/A0A803YPR9|||http://purl.uniprot.org/uniprot/G1N2K8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100542101 ^@ http://purl.uniprot.org/uniprot/G1MVH4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:GHRHR ^@ http://purl.uniprot.org/uniprot/G1MSI5|||http://purl.uniprot.org/uniprot/G3UU45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:KIN ^@ http://purl.uniprot.org/uniprot/G1MYZ9 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9103:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A803YQZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9103:POMK ^@ http://purl.uniprot.org/uniprot/G1MZ90 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/9103:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A803YAA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9103:DTX2 ^@ http://purl.uniprot.org/uniprot/A0A803YA81|||http://purl.uniprot.org/uniprot/A0A803YI51|||http://purl.uniprot.org/uniprot/A0A803YR13|||http://purl.uniprot.org/uniprot/G1MX29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9103:TVP23B ^@ http://purl.uniprot.org/uniprot/A0A803YKH9|||http://purl.uniprot.org/uniprot/G1MVZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9103:PRIMPOL ^@ http://purl.uniprot.org/uniprot/G1N3K7 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9103:FKBP5 ^@ http://purl.uniprot.org/uniprot/A0A803XZF0|||http://purl.uniprot.org/uniprot/A0A803YGG7|||http://purl.uniprot.org/uniprot/G1MPV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:DNASE2B ^@ http://purl.uniprot.org/uniprot/G1NAH7 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9103:SUSD6 ^@ http://purl.uniprot.org/uniprot/G1NH04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CDH22 ^@ http://purl.uniprot.org/uniprot/G1N841 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:IRX1 ^@ http://purl.uniprot.org/uniprot/A0A803XMK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9103:LOC100548849 ^@ http://purl.uniprot.org/uniprot/G1ND38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GJA4 ^@ http://purl.uniprot.org/uniprot/G5E807 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9103:BRINP1 ^@ http://purl.uniprot.org/uniprot/G1MW42 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9103:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/G1NPC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9103:LOC100550173 ^@ http://purl.uniprot.org/uniprot/G5E7R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:GCAT ^@ http://purl.uniprot.org/uniprot/G1NIM8 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9103:CYTB ^@ http://purl.uniprot.org/uniprot/P50663 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/9103:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/G1NP04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100542202 ^@ http://purl.uniprot.org/uniprot/G1NRI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/G1MRA7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9103:LOC100543567 ^@ http://purl.uniprot.org/uniprot/A0A803YAU4|||http://purl.uniprot.org/uniprot/G1N0V6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9103:LOC100540154 ^@ http://purl.uniprot.org/uniprot/G1MUL3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9103:SQLE ^@ http://purl.uniprot.org/uniprot/G1NJ84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:ANKRD13A ^@ http://purl.uniprot.org/uniprot/G1N439 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9103:LOC100303693 ^@ http://purl.uniprot.org/uniprot/G1NIB8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:PPRC1 ^@ http://purl.uniprot.org/uniprot/G1NCC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:NECAP2 ^@ http://purl.uniprot.org/uniprot/G1N0B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9103:CAVIN4 ^@ http://purl.uniprot.org/uniprot/G1N6F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola|||sarcomere http://togogenome.org/gene/9103:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A803YJB1 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9103:ASPA ^@ http://purl.uniprot.org/uniprot/A0A803YJA4|||http://purl.uniprot.org/uniprot/G1N4L9 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9103:NHSL2 ^@ http://purl.uniprot.org/uniprot/A0A803XYI1|||http://purl.uniprot.org/uniprot/G1MTA4 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9103:ZPBP ^@ http://purl.uniprot.org/uniprot/G1N3Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted http://togogenome.org/gene/9103:RBM22 ^@ http://purl.uniprot.org/uniprot/G1N3L9 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/9103:C4H4orf47 ^@ http://purl.uniprot.org/uniprot/G1NFV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0602 family.|||centrosome http://togogenome.org/gene/9103:PDE1C ^@ http://purl.uniprot.org/uniprot/A0A803Y584 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:LOC104912467 ^@ http://purl.uniprot.org/uniprot/G1NM66 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9103:LOC104912994 ^@ http://purl.uniprot.org/uniprot/A0A803Y555 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9103:SLC7A3 ^@ http://purl.uniprot.org/uniprot/G1MTP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC104914407 ^@ http://purl.uniprot.org/uniprot/A0A803YJ48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PPP6R2 ^@ http://purl.uniprot.org/uniprot/A0A803YFT8|||http://purl.uniprot.org/uniprot/G1MZ26 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9103:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A803YR93 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9103:PTGS2 ^@ http://purl.uniprot.org/uniprot/G1MRC2 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Endoplasmic reticulum membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/9103:MYADM ^@ http://purl.uniprot.org/uniprot/G1NRC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC104914523 ^@ http://purl.uniprot.org/uniprot/A0A803Y140 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:BCL2L1 ^@ http://purl.uniprot.org/uniprot/G1N5N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9103:LOC100550942 ^@ http://purl.uniprot.org/uniprot/G1NS57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:YIPF1 ^@ http://purl.uniprot.org/uniprot/G1NFN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A803Y192 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9103:STT3A ^@ http://purl.uniprot.org/uniprot/G1MPX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9103:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/G1NPS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9103:KPNA3 ^@ http://purl.uniprot.org/uniprot/A0A803YDA8 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/9103:CRABP2 ^@ http://purl.uniprot.org/uniprot/H9H0C7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9103:PCYT2 ^@ http://purl.uniprot.org/uniprot/A0A803YM84 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/9103:P2RX1 ^@ http://purl.uniprot.org/uniprot/G1MVE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9103:SCD ^@ http://purl.uniprot.org/uniprot/G1N6B0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9103:RACK1 ^@ http://purl.uniprot.org/uniprot/B1N1C2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/9103:EXTL3 ^@ http://purl.uniprot.org/uniprot/G1NN06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A803YGP3|||http://purl.uniprot.org/uniprot/G1NHE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9103:LOC100540904 ^@ http://purl.uniprot.org/uniprot/A0A803YFN1|||http://purl.uniprot.org/uniprot/G1N9X3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:HAAO ^@ http://purl.uniprot.org/uniprot/G1NCG5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9103:THRB ^@ http://purl.uniprot.org/uniprot/G1NEU6|||http://purl.uniprot.org/uniprot/G1NEW5|||http://purl.uniprot.org/uniprot/G3UR60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/9103:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A803Y123 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9103:GPX4 ^@ http://purl.uniprot.org/uniprot/D2J268 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9103:LOC100542048 ^@ http://purl.uniprot.org/uniprot/A0A803XME0|||http://purl.uniprot.org/uniprot/G1NRJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:LOC100544462 ^@ http://purl.uniprot.org/uniprot/G1N6I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:CTNS ^@ http://purl.uniprot.org/uniprot/G1N4B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9103:KLHL40 ^@ http://purl.uniprot.org/uniprot/G1MU07 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/9103:MRPS25 ^@ http://purl.uniprot.org/uniprot/G1NDA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9103:LOC104910066 ^@ http://purl.uniprot.org/uniprot/G1MVW5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9103:ELP3 ^@ http://purl.uniprot.org/uniprot/G1NN03 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9103:PTGR1 ^@ http://purl.uniprot.org/uniprot/G1N927 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9103:MSRB3 ^@ http://purl.uniprot.org/uniprot/G1ND17 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9103:MYOZ1 ^@ http://purl.uniprot.org/uniprot/G1N478 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9103:LLPH ^@ http://purl.uniprot.org/uniprot/G1NRH5 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9103:P2RY1 ^@ http://purl.uniprot.org/uniprot/P49652 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Mainly found in blood, brain, and lung. To a lesser extent in stomach, gut and skeletal muscle.|||Receptor for extracellular adenine nucleotides such as ADP (PubMed:8058061). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity). http://togogenome.org/gene/9103:LCA5L ^@ http://purl.uniprot.org/uniprot/G3USC2 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9103:CHAF1B ^@ http://purl.uniprot.org/uniprot/G1NNY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100550886 ^@ http://purl.uniprot.org/uniprot/A0A803Y5I3 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9103:FAM3C ^@ http://purl.uniprot.org/uniprot/G1N943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9103:INO80D ^@ http://purl.uniprot.org/uniprot/G1N914 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:P2RY8 ^@ http://purl.uniprot.org/uniprot/G1NPG4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:SH3PXD2A ^@ http://purl.uniprot.org/uniprot/A0A803XVS5|||http://purl.uniprot.org/uniprot/A0A803Y367 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm|||podosome http://togogenome.org/gene/9103:SEC24D ^@ http://purl.uniprot.org/uniprot/G1NE97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9103:GNPDA2 ^@ http://purl.uniprot.org/uniprot/G1NHQ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9103:WDFY2 ^@ http://purl.uniprot.org/uniprot/G1NQ68 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9103:ARSI ^@ http://purl.uniprot.org/uniprot/G1N451 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9103:KCNMB2 ^@ http://purl.uniprot.org/uniprot/G1NC17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CHAT ^@ http://purl.uniprot.org/uniprot/G1MTK0 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9103:TECPR1 ^@ http://purl.uniprot.org/uniprot/G1MS04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TECPR1 family.|||Lysosome membrane|||autophagosome membrane http://togogenome.org/gene/9103:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A803XNS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9103:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/A0A803YJ75 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9103:LRRC8C ^@ http://purl.uniprot.org/uniprot/G1N8Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100543036 ^@ http://purl.uniprot.org/uniprot/G1NFJ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to laminin.|||extracellular matrix http://togogenome.org/gene/9103:ADRA2C ^@ http://purl.uniprot.org/uniprot/G1NRL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A803YQP7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:SLC9A8 ^@ http://purl.uniprot.org/uniprot/H9H1R3 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/9103:RAD1 ^@ http://purl.uniprot.org/uniprot/G1MVY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9103:LOC104910121 ^@ http://purl.uniprot.org/uniprot/G1MYE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9103:TBXA2R ^@ http://purl.uniprot.org/uniprot/G1NRK3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100550265 ^@ http://purl.uniprot.org/uniprot/A0A803Y5Z5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Target cell membrane http://togogenome.org/gene/9103:GMDS ^@ http://purl.uniprot.org/uniprot/A0A803XY18 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9103:KLC4 ^@ http://purl.uniprot.org/uniprot/G1MXM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9103:ALDH1L2 ^@ http://purl.uniprot.org/uniprot/G1NJU7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9103:LOC104909313 ^@ http://purl.uniprot.org/uniprot/G1NGB6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:DAD1 ^@ http://purl.uniprot.org/uniprot/G1MPS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9103:SYT17 ^@ http://purl.uniprot.org/uniprot/G1N792 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9103:XRCC6 ^@ http://purl.uniprot.org/uniprot/G1NHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9103:GPR89B ^@ http://purl.uniprot.org/uniprot/G3URY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9103:VWA3A ^@ http://purl.uniprot.org/uniprot/A0A803XM96 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9103:TJP3 ^@ http://purl.uniprot.org/uniprot/G1MQN6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9103:LPL ^@ http://purl.uniprot.org/uniprot/G3UPD5 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9103:SMC4 ^@ http://purl.uniprot.org/uniprot/G1NDP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC4 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9103:EML4 ^@ http://purl.uniprot.org/uniprot/A0A803Y4G7|||http://purl.uniprot.org/uniprot/A0A803YBK2|||http://purl.uniprot.org/uniprot/A0A803YFB9|||http://purl.uniprot.org/uniprot/A0A803YM71 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9103:HSPA13 ^@ http://purl.uniprot.org/uniprot/G1NNS3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9103:CLDN2 ^@ http://purl.uniprot.org/uniprot/G1N0Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:KCNJ1 ^@ http://purl.uniprot.org/uniprot/G1NRH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9103:KMT2C ^@ http://purl.uniprot.org/uniprot/A0A803XUG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100549612 ^@ http://purl.uniprot.org/uniprot/G1NRF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9103:CCDC90B ^@ http://purl.uniprot.org/uniprot/A0A803YS27 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9103:RHCE ^@ http://purl.uniprot.org/uniprot/G1MSY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9103:NFE2L1 ^@ http://purl.uniprot.org/uniprot/H9H077 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. CNC subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9103:HYOU1 ^@ http://purl.uniprot.org/uniprot/G3UTS6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9103:DRAM2 ^@ http://purl.uniprot.org/uniprot/G1N106 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:FLCN ^@ http://purl.uniprot.org/uniprot/G1MYV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9103:IQSEC3 ^@ http://purl.uniprot.org/uniprot/G1NKY8 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/9103:GALC ^@ http://purl.uniprot.org/uniprot/G1NJZ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/9103:ADORA2A ^@ http://purl.uniprot.org/uniprot/G1N7D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9103:LOC100540961 ^@ http://purl.uniprot.org/uniprot/G1N4P9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:RPS14 ^@ http://purl.uniprot.org/uniprot/G1N479 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9103:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/G1MYL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9103:ARMC9 ^@ http://purl.uniprot.org/uniprot/A0A803YQ00 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cilium basal body http://togogenome.org/gene/9103:P2RX7 ^@ http://purl.uniprot.org/uniprot/G1MY55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9103:LOC100545821 ^@ http://purl.uniprot.org/uniprot/G1NLB2 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9103:JPT1 ^@ http://purl.uniprot.org/uniprot/G1NAT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:GPBP1 ^@ http://purl.uniprot.org/uniprot/G1NBC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9103:OTC ^@ http://purl.uniprot.org/uniprot/G1NP50 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9103:HEPH ^@ http://purl.uniprot.org/uniprot/A0A803XXC4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9103:CCKAR ^@ http://purl.uniprot.org/uniprot/G1NIH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9103:DAZL ^@ http://purl.uniprot.org/uniprot/A0A803YCJ1|||http://purl.uniprot.org/uniprot/G1NEH8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:CDKL1 ^@ http://purl.uniprot.org/uniprot/G1NLV2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A803XS45 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9103:CMC1 ^@ http://purl.uniprot.org/uniprot/G1NF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9103:SLC35A4 ^@ http://purl.uniprot.org/uniprot/G1NR35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9103:LOC104914070 ^@ http://purl.uniprot.org/uniprot/G1NAB9 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:LOC100549006 ^@ http://purl.uniprot.org/uniprot/A0A803YD08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:ANXA4 ^@ http://purl.uniprot.org/uniprot/H9H0B3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9103:LAMP1 ^@ http://purl.uniprot.org/uniprot/G1NPR7|||http://purl.uniprot.org/uniprot/G3UUP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9103:LOC100548689 ^@ http://purl.uniprot.org/uniprot/G1NIH0 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9103:EPHA7 ^@ http://purl.uniprot.org/uniprot/G1NLJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:HAT1 ^@ http://purl.uniprot.org/uniprot/G3UQ01 ^@ Similarity ^@ Belongs to the HAT1 family. http://togogenome.org/gene/9103:TWF1 ^@ http://purl.uniprot.org/uniprot/G1NB75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9103:ENPEP ^@ http://purl.uniprot.org/uniprot/A0A803XSJ5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homodimer; disulfide-linked. http://togogenome.org/gene/9103:EEF1B2 ^@ http://purl.uniprot.org/uniprot/G1N8V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9103:MAGT1 ^@ http://purl.uniprot.org/uniprot/G1N353 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:SGTA ^@ http://purl.uniprot.org/uniprot/G1MYR3 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9103:LOC100541147 ^@ http://purl.uniprot.org/uniprot/G1NCP6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:CACFD1 ^@ http://purl.uniprot.org/uniprot/G1N485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9103:VBP1 ^@ http://purl.uniprot.org/uniprot/G1N508 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9103:TP63 ^@ http://purl.uniprot.org/uniprot/A0A803YCS6|||http://purl.uniprot.org/uniprot/A0A803YHM5|||http://purl.uniprot.org/uniprot/G1MS14 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Nucleus http://togogenome.org/gene/9103:VOPP1 ^@ http://purl.uniprot.org/uniprot/A0A803XRJ7|||http://purl.uniprot.org/uniprot/A0A803YCC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9103:POLR1E ^@ http://purl.uniprot.org/uniprot/G1NA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9103:TAGLN ^@ http://purl.uniprot.org/uniprot/G1MWA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calponin family.|||Cytoplasm http://togogenome.org/gene/9103:F2R ^@ http://purl.uniprot.org/uniprot/A0A803Y891 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SMC3 ^@ http://purl.uniprot.org/uniprot/G1NEC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9103:YIPF7 ^@ http://purl.uniprot.org/uniprot/G1NHR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9103:KCNJ5 ^@ http://purl.uniprot.org/uniprot/G1MQM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9103:SIDT2 ^@ http://purl.uniprot.org/uniprot/G1MW96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9103:ND5 ^@ http://purl.uniprot.org/uniprot/A9XBE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:MVB12A ^@ http://purl.uniprot.org/uniprot/G1N198 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9103:MTFR1 ^@ http://purl.uniprot.org/uniprot/G1NFA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9103:GABRG1 ^@ http://purl.uniprot.org/uniprot/G1NHP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A803YF92 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9103:TMEM126A ^@ http://purl.uniprot.org/uniprot/G1NQQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PARP1 ^@ http://purl.uniprot.org/uniprot/G3UUR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. http://togogenome.org/gene/9103:ACTB ^@ http://purl.uniprot.org/uniprot/Q58J72 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A803YEQ7|||http://purl.uniprot.org/uniprot/G1NJ32 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9103:NLGN1 ^@ http://purl.uniprot.org/uniprot/G3X8M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100546173 ^@ http://purl.uniprot.org/uniprot/G1NNA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9103:CHST3 ^@ http://purl.uniprot.org/uniprot/G3URX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9103:CXCR5 ^@ http://purl.uniprot.org/uniprot/A0A803YHX8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:MOV10 ^@ http://purl.uniprot.org/uniprot/G1N067 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9103:TBXT ^@ http://purl.uniprot.org/uniprot/G1NIA4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:PTPN21 ^@ http://purl.uniprot.org/uniprot/G1NK10|||http://purl.uniprot.org/uniprot/G3X8L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9103:LOC100550610 ^@ http://purl.uniprot.org/uniprot/G1NR43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:AGTR1 ^@ http://purl.uniprot.org/uniprot/P33396 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Adrenal medulla.|||Belongs to the G-protein coupled receptor 1 family.|||C-terminal Ser or Thr residues may be phosphorylated.|||Cell membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/9103:AKR1D1 ^@ http://purl.uniprot.org/uniprot/G1NKF1 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9103:IBSP ^@ http://purl.uniprot.org/uniprot/G1N6F0 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9103:LOC100546355 ^@ http://purl.uniprot.org/uniprot/G1MUN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9103:PAN3 ^@ http://purl.uniprot.org/uniprot/G1NQC7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/9103:VGLL1 ^@ http://purl.uniprot.org/uniprot/G1MWZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9103:PSMD9 ^@ http://purl.uniprot.org/uniprot/G1MZ97 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9103:PAX5 ^@ http://purl.uniprot.org/uniprot/A0A803XUE3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:GABRB2 ^@ http://purl.uniprot.org/uniprot/G3UNX7|||http://purl.uniprot.org/uniprot/G3UPF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:BMT2 ^@ http://purl.uniprot.org/uniprot/A0A803XMQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9103:EMC6 ^@ http://purl.uniprot.org/uniprot/A0A803XQ42 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:TRIP13 ^@ http://purl.uniprot.org/uniprot/G1MSN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. PCH2 subfamily.|||Nucleus|||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. http://togogenome.org/gene/9103:NMNAT1 ^@ http://purl.uniprot.org/uniprot/G1MY88 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9103:TH ^@ http://purl.uniprot.org/uniprot/G1N7B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/9103:CCN6 ^@ http://purl.uniprot.org/uniprot/G1NL19 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:CTSO ^@ http://purl.uniprot.org/uniprot/G1MS56 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9103:GMNN ^@ http://purl.uniprot.org/uniprot/G1N7G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9103:CLDN1 ^@ http://purl.uniprot.org/uniprot/G1N6C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:UXS1 ^@ http://purl.uniprot.org/uniprot/G1NPP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9103:IARS1 ^@ http://purl.uniprot.org/uniprot/A0A803XNN9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9103:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A803Y9Z5|||http://purl.uniprot.org/uniprot/G1MX68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9103:PTHLH ^@ http://purl.uniprot.org/uniprot/G1NM77|||http://purl.uniprot.org/uniprot/G3UR06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/9103:CPEB3 ^@ http://purl.uniprot.org/uniprot/A0A803XNN0 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9103:ERCC4 ^@ http://purl.uniprot.org/uniprot/G1MQJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9103:GDF1 ^@ http://purl.uniprot.org/uniprot/G1MZR3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9103:FAM49B ^@ http://purl.uniprot.org/uniprot/A0A803XVX9|||http://purl.uniprot.org/uniprot/G1NJA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/9103:ATP4B ^@ http://purl.uniprot.org/uniprot/G1NPR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9103:LAMP3 ^@ http://purl.uniprot.org/uniprot/G1NB36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9103:ALDOB ^@ http://purl.uniprot.org/uniprot/G1N4K3 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9103:SLC16A7 ^@ http://purl.uniprot.org/uniprot/G1NCE2 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9103:PAMR1 ^@ http://purl.uniprot.org/uniprot/A0A803XQD5|||http://purl.uniprot.org/uniprot/G1ND63 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:RPS29 ^@ http://purl.uniprot.org/uniprot/G1NLR9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9103:MRPL15 ^@ http://purl.uniprot.org/uniprot/G1NEM9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9103:SNX4 ^@ http://purl.uniprot.org/uniprot/G1NHV5 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9103:LOC104913618 ^@ http://purl.uniprot.org/uniprot/A0A803XV95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100541131 ^@ http://purl.uniprot.org/uniprot/G1NNG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/9103:FAM102B ^@ http://purl.uniprot.org/uniprot/G1N371 ^@ Similarity ^@ Belongs to the FAM102 family. http://togogenome.org/gene/9103:TMEM258 ^@ http://purl.uniprot.org/uniprot/G1MZL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9103:IST1 ^@ http://purl.uniprot.org/uniprot/G1N9K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9103:LOC100538956 ^@ http://purl.uniprot.org/uniprot/G1N517 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9103:FOXJ2 ^@ http://purl.uniprot.org/uniprot/G1NMD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:BEST3 ^@ http://purl.uniprot.org/uniprot/G1NPE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/9103:SKP1 ^@ http://purl.uniprot.org/uniprot/G1N8G6 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. http://togogenome.org/gene/9103:SCP2 ^@ http://purl.uniprot.org/uniprot/G1NFG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Mitochondrion|||Peroxisome http://togogenome.org/gene/9103:LOC100546642 ^@ http://purl.uniprot.org/uniprot/G1N5D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9103:LOC104914035 ^@ http://purl.uniprot.org/uniprot/A0A803YFF6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CAPN10 ^@ http://purl.uniprot.org/uniprot/A0A803XUN3|||http://purl.uniprot.org/uniprot/G1N9E1 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:LOC100544241 ^@ http://purl.uniprot.org/uniprot/G1NES7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:GPS1 ^@ http://purl.uniprot.org/uniprot/G1N0U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:LEPROT ^@ http://purl.uniprot.org/uniprot/Q5PSV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the OB-RGRP/VPS55 family.|||Endosome membrane|||Golgi apparatus membrane|||Involved in protein trafficking. May be involved in the down-regulation of membrane protein levels (By similarity).|||Widely expressed, including in liver, duodenum, kidney, pancreas, lung, spleen and brain. http://togogenome.org/gene/9103:VPS36 ^@ http://purl.uniprot.org/uniprot/G1NQ74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/9103:TNNT2 ^@ http://purl.uniprot.org/uniprot/Q90YN7 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9103:CD2 ^@ http://purl.uniprot.org/uniprot/G1NNP8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:PTPA ^@ http://purl.uniprot.org/uniprot/G1N0B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9103:SBNO1 ^@ http://purl.uniprot.org/uniprot/G1MWA8 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9103:VSIG1 ^@ http://purl.uniprot.org/uniprot/A0A803YLE5|||http://purl.uniprot.org/uniprot/G1N4X1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100550170 ^@ http://purl.uniprot.org/uniprot/A0A803YBR8|||http://purl.uniprot.org/uniprot/G1NHF4 ^@ Similarity ^@ Belongs to the FMC1 family.|||Belongs to the Luc7 family. http://togogenome.org/gene/9103:SAXO1 ^@ http://purl.uniprot.org/uniprot/G1N1Y4 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9103:DISP3 ^@ http://purl.uniprot.org/uniprot/A0A803Y6P8|||http://purl.uniprot.org/uniprot/G1N3U1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:HMX2 ^@ http://purl.uniprot.org/uniprot/G1NGF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100541793 ^@ http://purl.uniprot.org/uniprot/A0A803XUP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9103:SLC5A9 ^@ http://purl.uniprot.org/uniprot/G1NEE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9103:SLC2A12 ^@ http://purl.uniprot.org/uniprot/G1NKB4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9103:OTOP3 ^@ http://purl.uniprot.org/uniprot/G1NAK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:TRAK1 ^@ http://purl.uniprot.org/uniprot/G1NGQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9103:TMA16 ^@ http://purl.uniprot.org/uniprot/G1MTF3 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9103:CDK1 ^@ http://purl.uniprot.org/uniprot/G1MVE7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:HYAL1 ^@ http://purl.uniprot.org/uniprot/G1MRN3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9103:PRKAR1A ^@ http://purl.uniprot.org/uniprot/G3UQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GPHB5 ^@ http://purl.uniprot.org/uniprot/G1NLC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9103:SLC26A2 ^@ http://purl.uniprot.org/uniprot/G1MVS5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sulfate transporter. May play a role in endochondral bone formation. http://togogenome.org/gene/9103:MUL1 ^@ http://purl.uniprot.org/uniprot/G1N2C7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SPON2 ^@ http://purl.uniprot.org/uniprot/G1NK95 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9103:ENTPD1 ^@ http://purl.uniprot.org/uniprot/G1NAS8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9103:NIPAL4 ^@ http://purl.uniprot.org/uniprot/G1N0L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9103:RPF2 ^@ http://purl.uniprot.org/uniprot/G1NL34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9103:WNT5A ^@ http://purl.uniprot.org/uniprot/A0A803YDB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9103:SBDS ^@ http://purl.uniprot.org/uniprot/G3UPX1 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9103:SERPINC1 ^@ http://purl.uniprot.org/uniprot/G3UNT4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9103:HMBS ^@ http://purl.uniprot.org/uniprot/A0A803YKM5|||http://purl.uniprot.org/uniprot/G1MWI3 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9103:HTR3A ^@ http://purl.uniprot.org/uniprot/G1MVD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9103:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A803XTM3|||http://purl.uniprot.org/uniprot/G1NNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/9103:PITHD1 ^@ http://purl.uniprot.org/uniprot/A0A803Y9W5 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/9103:MEGF10 ^@ http://purl.uniprot.org/uniprot/A0A803Y022|||http://purl.uniprot.org/uniprot/G1N7B5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A803YSD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9103:NBN ^@ http://purl.uniprot.org/uniprot/A0A803XZX2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/9103:HSBP1 ^@ http://purl.uniprot.org/uniprot/A0A803XTU6 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9103:NCK2 ^@ http://purl.uniprot.org/uniprot/G1NPP1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9103:VPS37B ^@ http://purl.uniprot.org/uniprot/A0A803XY54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9103:SERPINE3 ^@ http://purl.uniprot.org/uniprot/A0A803YJL6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:MMP7 ^@ http://purl.uniprot.org/uniprot/G3UV36 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9103:CLN8 ^@ http://purl.uniprot.org/uniprot/G1NMF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:EXOC3 ^@ http://purl.uniprot.org/uniprot/G1N6I0 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9103:CUL1 ^@ http://purl.uniprot.org/uniprot/G1MRX7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9103:SF3A2 ^@ http://purl.uniprot.org/uniprot/G1MSY8 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/9103:MED10 ^@ http://purl.uniprot.org/uniprot/G1N3T7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9103:RPL35A ^@ http://purl.uniprot.org/uniprot/G1N7Q5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9103:FLI1 ^@ http://purl.uniprot.org/uniprot/G1MQM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:ST14 ^@ http://purl.uniprot.org/uniprot/G1MR46 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Degrades extracellular matrix.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:APOB ^@ http://purl.uniprot.org/uniprot/G1NMN7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC104911571 ^@ http://purl.uniprot.org/uniprot/G1NKB0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/G1MSD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9103:MARCO ^@ http://purl.uniprot.org/uniprot/A0A803YJ71 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:TSPO ^@ http://purl.uniprot.org/uniprot/G1NLY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9103:DHFR ^@ http://purl.uniprot.org/uniprot/H9H0F8 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9103:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A803YEW9|||http://purl.uniprot.org/uniprot/A0A803YMX0|||http://purl.uniprot.org/uniprot/G1N3B4 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9103:BIRC2 ^@ http://purl.uniprot.org/uniprot/G1NQK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:INTS2 ^@ http://purl.uniprot.org/uniprot/G3UPW3 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/9103:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A803Y2S4|||http://purl.uniprot.org/uniprot/A0A803Y4W1|||http://purl.uniprot.org/uniprot/A0A803Y643|||http://purl.uniprot.org/uniprot/A0A803YM86 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9103:ACTA1 ^@ http://purl.uniprot.org/uniprot/G1NHJ8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:UBA5 ^@ http://purl.uniprot.org/uniprot/G1NG60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Golgi apparatus http://togogenome.org/gene/9103:LOC100541871 ^@ http://purl.uniprot.org/uniprot/G1N1X5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100551074 ^@ http://purl.uniprot.org/uniprot/G1MTI3|||http://purl.uniprot.org/uniprot/G3UQT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TTC19 ^@ http://purl.uniprot.org/uniprot/G1N3I3 ^@ Similarity ^@ Belongs to the TTC19 family. http://togogenome.org/gene/9103:RAD50 ^@ http://purl.uniprot.org/uniprot/G1N9X5 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9103:ATP12A ^@ http://purl.uniprot.org/uniprot/G1MSL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/9103:CD34 ^@ http://purl.uniprot.org/uniprot/G1MYF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:VPS29 ^@ http://purl.uniprot.org/uniprot/G1N0C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9103:FAM149B1 ^@ http://purl.uniprot.org/uniprot/G1MRF1 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9103:LOC100548019 ^@ http://purl.uniprot.org/uniprot/G1NNC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9103:FSCN2 ^@ http://purl.uniprot.org/uniprot/A0A803Y170 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9103:SEC61A1 ^@ http://purl.uniprot.org/uniprot/G1N5Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:MME ^@ http://purl.uniprot.org/uniprot/A0A803YIV2|||http://purl.uniprot.org/uniprot/G1NEB9 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/9103:GGA1 ^@ http://purl.uniprot.org/uniprot/G1NIY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:STX19 ^@ http://purl.uniprot.org/uniprot/G1NS42 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9103:MEOX1 ^@ http://purl.uniprot.org/uniprot/G3UTX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:BBOX1 ^@ http://purl.uniprot.org/uniprot/G1MSH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine.|||Cytoplasm http://togogenome.org/gene/9103:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/G1N5W1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:SCNN1G ^@ http://purl.uniprot.org/uniprot/G1N4M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:NKAIN3 ^@ http://purl.uniprot.org/uniprot/A0A803Y7S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GPAM ^@ http://purl.uniprot.org/uniprot/G1NEH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9103:ANXA5 ^@ http://purl.uniprot.org/uniprot/G1NDY6 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9103:MRPL42 ^@ http://purl.uniprot.org/uniprot/G1NFQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9103:GSTK1 ^@ http://purl.uniprot.org/uniprot/G1NMZ9 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9103:EEF1D ^@ http://purl.uniprot.org/uniprot/G1NK44 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9103:LOC100550820 ^@ http://purl.uniprot.org/uniprot/A0A803XK90 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:MIOS ^@ http://purl.uniprot.org/uniprot/G1NBV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/9103:LOC100550128 ^@ http://purl.uniprot.org/uniprot/G1NGJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9103:RFC2 ^@ http://purl.uniprot.org/uniprot/G1MUA0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9103:LOC104912200 ^@ http://purl.uniprot.org/uniprot/G1NM14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9103:CHRNA3 ^@ http://purl.uniprot.org/uniprot/G1MWZ2|||http://purl.uniprot.org/uniprot/G3UV88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:ARL6 ^@ http://purl.uniprot.org/uniprot/G1NNM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9103:LOC100546606 ^@ http://purl.uniprot.org/uniprot/A0A803YSY4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:IL10 ^@ http://purl.uniprot.org/uniprot/A2VBZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9103:EPC2 ^@ http://purl.uniprot.org/uniprot/G1NJ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9103:MYLK ^@ http://purl.uniprot.org/uniprot/G1U9Q7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/9103:BRCC3 ^@ http://purl.uniprot.org/uniprot/G1NA48 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9103:PHF10 ^@ http://purl.uniprot.org/uniprot/G1NHZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/9103:FAM110B ^@ http://purl.uniprot.org/uniprot/G1NRR2 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9103:IFITM5 ^@ http://purl.uniprot.org/uniprot/G1MUD2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9103:DARS1 ^@ http://purl.uniprot.org/uniprot/G1NIS2 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9103:ADRA1A ^@ http://purl.uniprot.org/uniprot/G1MWX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9103:LOXL2 ^@ http://purl.uniprot.org/uniprot/G1MRH0 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9103:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A803YBV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9103:CTNNBIP1 ^@ http://purl.uniprot.org/uniprot/G1MYC9 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9103:BTF3L4 ^@ http://purl.uniprot.org/uniprot/G1NF34 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9103:RGN ^@ http://purl.uniprot.org/uniprot/G1NPH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9103:SCNN1A ^@ http://purl.uniprot.org/uniprot/A0A803YS31|||http://purl.uniprot.org/uniprot/G1NMK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:OAT ^@ http://purl.uniprot.org/uniprot/G1NGK9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9103:SLC37A1 ^@ http://purl.uniprot.org/uniprot/A0A803XRZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9103:MUC2 ^@ http://purl.uniprot.org/uniprot/G1N988 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:FGF12 ^@ http://purl.uniprot.org/uniprot/G1N612 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9103:LOC100550807 ^@ http://purl.uniprot.org/uniprot/G1N3D8 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9103:HOGA1 ^@ http://purl.uniprot.org/uniprot/G1NBP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9103:LOC100538984 ^@ http://purl.uniprot.org/uniprot/G1NGN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100542307 ^@ http://purl.uniprot.org/uniprot/G1NME1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9103:BIRC7 ^@ http://purl.uniprot.org/uniprot/A0A803XTE3|||http://purl.uniprot.org/uniprot/G1N383 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9103:STARD3NL ^@ http://purl.uniprot.org/uniprot/G1NHA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9103:LOC100548069 ^@ http://purl.uniprot.org/uniprot/H9H0P0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:DUOXA2 ^@ http://purl.uniprot.org/uniprot/G1MQL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9103:RXRA ^@ http://purl.uniprot.org/uniprot/A0A803XQT3|||http://purl.uniprot.org/uniprot/G1N4W9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9103:ORC3 ^@ http://purl.uniprot.org/uniprot/G1NLN3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/9103:ADGRL4 ^@ http://purl.uniprot.org/uniprot/G1NAS1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:LOC100547404 ^@ http://purl.uniprot.org/uniprot/G1NPZ8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:ELOVL7 ^@ http://purl.uniprot.org/uniprot/A0A803YKX3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A803XXB0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9103:SH3RF1 ^@ http://purl.uniprot.org/uniprot/G1MUP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9103:LOC100542160 ^@ http://purl.uniprot.org/uniprot/G1NQS4 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9103:TMEM269 ^@ http://purl.uniprot.org/uniprot/G1N5B0 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9103:RPL32 ^@ http://purl.uniprot.org/uniprot/G1NCW3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9103:LOC100539605 ^@ http://purl.uniprot.org/uniprot/A0A803Y3W9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9103:BEST4 ^@ http://purl.uniprot.org/uniprot/G1NCN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/9103:PPP6R3 ^@ http://purl.uniprot.org/uniprot/G1NAS9 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9103:LOC100547278 ^@ http://purl.uniprot.org/uniprot/A0A803YFI4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9103:NFRKB ^@ http://purl.uniprot.org/uniprot/G1MQZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PEX2 ^@ http://purl.uniprot.org/uniprot/G1NRR8 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/9103:KLHL36 ^@ http://purl.uniprot.org/uniprot/G1N5H8 ^@ Function ^@ Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9103:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A803XSJ9|||http://purl.uniprot.org/uniprot/G1MUL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9103:CEP19 ^@ http://purl.uniprot.org/uniprot/G1MW16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9103:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A803YK88 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9103:TMEM35A ^@ http://purl.uniprot.org/uniprot/G1NAL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane|||Vesicle http://togogenome.org/gene/9103:TRPV3 ^@ http://purl.uniprot.org/uniprot/A0A803Y4P2|||http://purl.uniprot.org/uniprot/G1N4L0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CALHM1 ^@ http://purl.uniprot.org/uniprot/G1NDJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9103:MAFF ^@ http://purl.uniprot.org/uniprot/G1NRW8 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9103:LOC100551323 ^@ http://purl.uniprot.org/uniprot/G1MXR8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A803XXT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/9103:YWHAB ^@ http://purl.uniprot.org/uniprot/G1MXY2 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9103:SLC15A1 ^@ http://purl.uniprot.org/uniprot/Q802B1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9103:SLC6A11 ^@ http://purl.uniprot.org/uniprot/G1MZX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9103:NIPA1 ^@ http://purl.uniprot.org/uniprot/G1NPI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9103:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A803XRN1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/G1N6D6 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9103:DPF3 ^@ http://purl.uniprot.org/uniprot/G1NGS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLC25A47 ^@ http://purl.uniprot.org/uniprot/A0A803YIJ2|||http://purl.uniprot.org/uniprot/G1NKT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:ADA2 ^@ http://purl.uniprot.org/uniprot/G1NL66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/9103:SUCLA2 ^@ http://purl.uniprot.org/uniprot/G1NQ49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/9103:MTFR2 ^@ http://purl.uniprot.org/uniprot/G1NK37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9103:GLRB ^@ http://purl.uniprot.org/uniprot/G1MSC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9103:VEGFD ^@ http://purl.uniprot.org/uniprot/G1NPC2 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9103:RFLNA ^@ http://purl.uniprot.org/uniprot/A0A803YGR0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/9103:ATP8 ^@ http://purl.uniprot.org/uniprot/A9XBE3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9103:EPB41 ^@ http://purl.uniprot.org/uniprot/G1MTV8 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex http://togogenome.org/gene/9103:AQP11 ^@ http://purl.uniprot.org/uniprot/G1NQT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9103:COPG2 ^@ http://purl.uniprot.org/uniprot/G1MW97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9103:CD38 ^@ http://purl.uniprot.org/uniprot/G1NJ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADP-ribosyl cyclase family.|||Membrane http://togogenome.org/gene/9103:ZHX2 ^@ http://purl.uniprot.org/uniprot/G1NRS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9103:TIMP3 ^@ http://purl.uniprot.org/uniprot/G1NJF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||extracellular matrix http://togogenome.org/gene/9103:TACSTD2 ^@ http://purl.uniprot.org/uniprot/G1NR03 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/G1N8V8 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/9103:CLCN2 ^@ http://purl.uniprot.org/uniprot/G5E7P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100549470 ^@ http://purl.uniprot.org/uniprot/G1N1N0 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9103:SGK1 ^@ http://purl.uniprot.org/uniprot/G1NKB1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:CLCN4 ^@ http://purl.uniprot.org/uniprot/G1NPE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9103:PRPS2 ^@ http://purl.uniprot.org/uniprot/G1NPD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9103:LOC100547885 ^@ http://purl.uniprot.org/uniprot/A0A803YCG1|||http://purl.uniprot.org/uniprot/G1MTX1|||http://purl.uniprot.org/uniprot/G3USN2|||http://purl.uniprot.org/uniprot/G3UTV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9103:TIPRL ^@ http://purl.uniprot.org/uniprot/G1NNG2 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9103:LYPD6 ^@ http://purl.uniprot.org/uniprot/G1NJA2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:PRKAB1 ^@ http://purl.uniprot.org/uniprot/G1NA04 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9103:GPR65 ^@ http://purl.uniprot.org/uniprot/G1NR06 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:CCT2 ^@ http://purl.uniprot.org/uniprot/G1NPD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9103:ACKR3 ^@ http://purl.uniprot.org/uniprot/G1NS69 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:LOC100538694 ^@ http://purl.uniprot.org/uniprot/G1N6B2|||http://purl.uniprot.org/uniprot/Q71SZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/G1N8Z4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.|||centrosome|||cytoskeleton http://togogenome.org/gene/9103:TIPIN ^@ http://purl.uniprot.org/uniprot/G1NBZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9103:TMEM138 ^@ http://purl.uniprot.org/uniprot/G1N056 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9103:LOC100543476 ^@ http://purl.uniprot.org/uniprot/G1NR19 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:EDN2 ^@ http://purl.uniprot.org/uniprot/G1MQC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9103:OPRK1 ^@ http://purl.uniprot.org/uniprot/G1NEI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with SLC9A3R1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/9103:PIK3CA ^@ http://purl.uniprot.org/uniprot/G1NC03 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9103:LOC100543904 ^@ http://purl.uniprot.org/uniprot/G1MVL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:OTULINL ^@ http://purl.uniprot.org/uniprot/G1N2E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9103:SETD7 ^@ http://purl.uniprot.org/uniprot/G1MV93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9103:SFR1 ^@ http://purl.uniprot.org/uniprot/G1NDQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9103:CTSC ^@ http://purl.uniprot.org/uniprot/G1NQP8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C1 family.|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9103:RAMP2 ^@ http://purl.uniprot.org/uniprot/A0A803YN35 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9103:PLAGL2 ^@ http://purl.uniprot.org/uniprot/G1N6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9103:CEL ^@ http://purl.uniprot.org/uniprot/G1N3B6 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9103:SNRPD3 ^@ http://purl.uniprot.org/uniprot/G1NR68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/9103:SEC23A ^@ http://purl.uniprot.org/uniprot/G1NIW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9103:TET2 ^@ http://purl.uniprot.org/uniprot/G1N320 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9103:PWWP3A ^@ http://purl.uniprot.org/uniprot/A0A803XMD2 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9103:UBE2E1 ^@ http://purl.uniprot.org/uniprot/G1NET4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/G1NEU2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9103:TSEN2 ^@ http://purl.uniprot.org/uniprot/G1N0H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9103:MB ^@ http://purl.uniprot.org/uniprot/G1NJB6 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9103:LOC100550679 ^@ http://purl.uniprot.org/uniprot/G1NLX1 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9103:LOC100548654 ^@ http://purl.uniprot.org/uniprot/G1MXM6 ^@ Similarity ^@ Belongs to the janus family. http://togogenome.org/gene/9103:TP73 ^@ http://purl.uniprot.org/uniprot/G1MS29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Found in a complex with p53/TP53 and CABLES1.|||Nucleus|||Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. http://togogenome.org/gene/9103:LIPI ^@ http://purl.uniprot.org/uniprot/G1NNS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9103:PPM1A ^@ http://purl.uniprot.org/uniprot/G1NLF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9103:NSG2 ^@ http://purl.uniprot.org/uniprot/G1MX83 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9103:EEF1A2 ^@ http://purl.uniprot.org/uniprot/G3UPD8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9103:MRPS14 ^@ http://purl.uniprot.org/uniprot/G1MTD2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9103:LIN9 ^@ http://purl.uniprot.org/uniprot/G3UUN7 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/9103:CPLX2 ^@ http://purl.uniprot.org/uniprot/G1MZU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9103:LOC100540643 ^@ http://purl.uniprot.org/uniprot/G1MRE4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CLRN2 ^@ http://purl.uniprot.org/uniprot/G1NIY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9103:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A803YFV5 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9103:RAB14 ^@ http://purl.uniprot.org/uniprot/G1N6Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9103:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A803Y6E8|||http://purl.uniprot.org/uniprot/G1N0J3 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9103:NHS ^@ http://purl.uniprot.org/uniprot/G1NPA8 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9103:CXCL12 ^@ http://purl.uniprot.org/uniprot/G1N7W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9103:IP6K3 ^@ http://purl.uniprot.org/uniprot/H9H1P0 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9103:SLC6A17 ^@ http://purl.uniprot.org/uniprot/G1MTV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9103:GSTA4 ^@ http://purl.uniprot.org/uniprot/C8BLR6 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9103:LOC100548675 ^@ http://purl.uniprot.org/uniprot/G1NRE6 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/9103:TMSB15B ^@ http://purl.uniprot.org/uniprot/A0A803XNI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9103:LOC100538839 ^@ http://purl.uniprot.org/uniprot/G1NE02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9103:PLAG1 ^@ http://purl.uniprot.org/uniprot/G1NET2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9103:METTL8 ^@ http://purl.uniprot.org/uniprot/G1NCP0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9103:ACADS ^@ http://purl.uniprot.org/uniprot/A0A803YJE6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9103:FABP7 ^@ http://purl.uniprot.org/uniprot/G1NKS8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9103:DMRT2 ^@ http://purl.uniprot.org/uniprot/G1NS45 ^@ Similarity ^@ Belongs to the DMRT family. http://togogenome.org/gene/9103:GREM1 ^@ http://purl.uniprot.org/uniprot/G1NQZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9103:LPAR1 ^@ http://purl.uniprot.org/uniprot/G1N932 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9103:DHRS7 ^@ http://purl.uniprot.org/uniprot/G1NLG0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:UBA52 ^@ http://purl.uniprot.org/uniprot/A0A803Y4P4 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/9103:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A803YL51|||http://purl.uniprot.org/uniprot/G1N5T3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9103:LAMC2 ^@ http://purl.uniprot.org/uniprot/G1MSC8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9103:NMUR1 ^@ http://purl.uniprot.org/uniprot/G1N7Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9103:MC2R ^@ http://purl.uniprot.org/uniprot/G1NRQ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9103:SH3GL3 ^@ http://purl.uniprot.org/uniprot/G3UPC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9103:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A803XM89|||http://purl.uniprot.org/uniprot/A0A803YHG7|||http://purl.uniprot.org/uniprot/G1NK36 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9103:PARD6B ^@ http://purl.uniprot.org/uniprot/G3USZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9103:GSTA1.3 ^@ http://purl.uniprot.org/uniprot/A0A803YD55|||http://purl.uniprot.org/uniprot/C8BLR3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9103:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A803Y9M9|||http://purl.uniprot.org/uniprot/G1NLT9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9103:CSNK1E ^@ http://purl.uniprot.org/uniprot/G1NIL4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:INTS12 ^@ http://purl.uniprot.org/uniprot/G1N2V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 12 family.|||Nucleus http://togogenome.org/gene/9103:GSDME ^@ http://purl.uniprot.org/uniprot/G3UR30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:ROGDI ^@ http://purl.uniprot.org/uniprot/G1NCV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rogdi family.|||Perikaryon|||Presynapse|||synaptic vesicle http://togogenome.org/gene/9103:TSSK6 ^@ http://purl.uniprot.org/uniprot/G1NS75 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:MTNR1A ^@ http://purl.uniprot.org/uniprot/G1NG10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:RPSA ^@ http://purl.uniprot.org/uniprot/G1NGU2 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9103:CYC ^@ http://purl.uniprot.org/uniprot/P67882 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||The turkey sequence appears to be identical with that of chicken. http://togogenome.org/gene/9103:FABP2 ^@ http://purl.uniprot.org/uniprot/G1NE55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/9103:CWC25 ^@ http://purl.uniprot.org/uniprot/G1N0R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/9103:ATP5PF ^@ http://purl.uniprot.org/uniprot/G1NNT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100541854 ^@ http://purl.uniprot.org/uniprot/G1N604 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9103:TBPL2 ^@ http://purl.uniprot.org/uniprot/G1NLM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9103:TOR1B ^@ http://purl.uniprot.org/uniprot/G1N0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9103:LOC100539645 ^@ http://purl.uniprot.org/uniprot/A0A803XLX5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:LOC100541463 ^@ http://purl.uniprot.org/uniprot/G3UPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane|||Secreted http://togogenome.org/gene/9103:PRMT7 ^@ http://purl.uniprot.org/uniprot/G1MXM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/9103:LOC100538525 ^@ http://purl.uniprot.org/uniprot/A0A803XM99 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9103:LOC104910575 ^@ http://purl.uniprot.org/uniprot/A0A803Y8I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9103:NOS2 ^@ http://purl.uniprot.org/uniprot/G1N8R3|||http://purl.uniprot.org/uniprot/H6S058 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/9103:DPT ^@ http://purl.uniprot.org/uniprot/G1NNG0 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9103:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A803YKS5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9103:CPSF2 ^@ http://purl.uniprot.org/uniprot/G1NKB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9103:HENMT1 ^@ http://purl.uniprot.org/uniprot/G1N390 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9103:IRF7 ^@ http://purl.uniprot.org/uniprot/G1NA74 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:WDR3 ^@ http://purl.uniprot.org/uniprot/G1NN59 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9103:LEAP2 ^@ http://purl.uniprot.org/uniprot/G1NA89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9103:UTS2B ^@ http://purl.uniprot.org/uniprot/G1N642 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9103:LOC100543228 ^@ http://purl.uniprot.org/uniprot/G1MXQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family. Ago subfamily.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9103:LOC100538434 ^@ http://purl.uniprot.org/uniprot/G1NE81 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/G1MZA7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:RPL27A ^@ http://purl.uniprot.org/uniprot/G1N3Y5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9103:HACL1 ^@ http://purl.uniprot.org/uniprot/G1NEC4 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9103:YJU2 ^@ http://purl.uniprot.org/uniprot/H9H1K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/9103:LOC100540332 ^@ http://purl.uniprot.org/uniprot/G1MTF8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9103:C1H2orf49 ^@ http://purl.uniprot.org/uniprot/G1NPN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9103:OTULIN ^@ http://purl.uniprot.org/uniprot/G1N2D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9103:MBTD1 ^@ http://purl.uniprot.org/uniprot/A0A803YN29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100549737 ^@ http://purl.uniprot.org/uniprot/G1NRF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9103:RIDA ^@ http://purl.uniprot.org/uniprot/G1NHU5 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/9103:ODR4 ^@ http://purl.uniprot.org/uniprot/G1MR07 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9103:VPS26C ^@ http://purl.uniprot.org/uniprot/G1NNY7 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/9103:EDA2R ^@ http://purl.uniprot.org/uniprot/G1MQB5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC104913559 ^@ http://purl.uniprot.org/uniprot/A0A803YA42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A803YEC9 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9103:CAP2 ^@ http://purl.uniprot.org/uniprot/G1MVS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/9103:SLC41A1 ^@ http://purl.uniprot.org/uniprot/G1MVU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9103:CP ^@ http://purl.uniprot.org/uniprot/A0A803YMC9 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9103:IL15 ^@ http://purl.uniprot.org/uniprot/G1MW49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9103:GCG ^@ http://purl.uniprot.org/uniprot/Q3HLJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9103:GRPEL1 ^@ http://purl.uniprot.org/uniprot/G1NJK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9103:NCSTN ^@ http://purl.uniprot.org/uniprot/H9H0Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9103:CDKN1B ^@ http://purl.uniprot.org/uniprot/G1NM67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDI family.|||Cytoplasm|||Endosome|||Nucleus http://togogenome.org/gene/9103:ERG ^@ http://purl.uniprot.org/uniprot/A0A803YJ32|||http://purl.uniprot.org/uniprot/G1NNZ0|||http://purl.uniprot.org/uniprot/G3URM9|||http://purl.uniprot.org/uniprot/G3UT55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:OAZ1 ^@ http://purl.uniprot.org/uniprot/G1MT34 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9103:LOC100544862 ^@ http://purl.uniprot.org/uniprot/G1NEY4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:KCNJ13 ^@ http://purl.uniprot.org/uniprot/G1MSR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9103:NRTN ^@ http://purl.uniprot.org/uniprot/A0A803YNF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9103:SORL1 ^@ http://purl.uniprot.org/uniprot/G1MT79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS10-related sortilin family. SORL1 subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Recycling endosome membrane|||Secreted|||multivesicular body membrane|||secretory vesicle membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/G1NL74 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9103:DIPK1C ^@ http://purl.uniprot.org/uniprot/G1N801 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:CFAP206 ^@ http://purl.uniprot.org/uniprot/G1NLP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9103:SSTR4 ^@ http://purl.uniprot.org/uniprot/G1MVY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100549030 ^@ http://purl.uniprot.org/uniprot/A0A803XTY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100548761 ^@ http://purl.uniprot.org/uniprot/A0A803YMP6 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9103:AFF4 ^@ http://purl.uniprot.org/uniprot/G1NAC6 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9103:LOC100546734 ^@ http://purl.uniprot.org/uniprot/G1MQR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9103:MED16 ^@ http://purl.uniprot.org/uniprot/G1MVG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9103:LOC104910687 ^@ http://purl.uniprot.org/uniprot/G1N5F9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:SYS1 ^@ http://purl.uniprot.org/uniprot/A0A803XU74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9103:NOL12 ^@ http://purl.uniprot.org/uniprot/G1NIU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/9103:LOC100539813 ^@ http://purl.uniprot.org/uniprot/G1NED7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9103:LOC116216167 ^@ http://purl.uniprot.org/uniprot/A0A803YPB9 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9103:NFYB ^@ http://purl.uniprot.org/uniprot/G1NJX0|||http://purl.uniprot.org/uniprot/G3UPA1 ^@ Function|||Similarity ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. http://togogenome.org/gene/9103:TAF8 ^@ http://purl.uniprot.org/uniprot/G1N3L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9103:LOC100303688 ^@ http://purl.uniprot.org/uniprot/Q9PT81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9103:MDFI ^@ http://purl.uniprot.org/uniprot/G1N368 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9103:EXOC2 ^@ http://purl.uniprot.org/uniprot/G1MZ48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9103:LOC100548708 ^@ http://purl.uniprot.org/uniprot/G1N971 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9103:PLAGL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y2T5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:MAD1L1 ^@ http://purl.uniprot.org/uniprot/G1MUQ9 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/9103:KCNS2 ^@ http://purl.uniprot.org/uniprot/G1NRS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ARRDC2 ^@ http://purl.uniprot.org/uniprot/H9H0N6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9103:SLC23A1 ^@ http://purl.uniprot.org/uniprot/G1MRD2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A803Y4W8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9103:CMC2 ^@ http://purl.uniprot.org/uniprot/G1N4I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9103:DCP1A ^@ http://purl.uniprot.org/uniprot/G1N267 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9103:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A803YFF3|||http://purl.uniprot.org/uniprot/G1N0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9103:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/G1NJ64 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9103:RARB ^@ http://purl.uniprot.org/uniprot/G1NEZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:NUP35 ^@ http://purl.uniprot.org/uniprot/G1MYZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9103:MSTN ^@ http://purl.uniprot.org/uniprot/O42221 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/9103:DLL1 ^@ http://purl.uniprot.org/uniprot/G1NHX8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9103:LOC100551205 ^@ http://purl.uniprot.org/uniprot/A0A803YH58 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9103:RALY ^@ http://purl.uniprot.org/uniprot/A0A803XWX7 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9103:LOC104914419 ^@ http://purl.uniprot.org/uniprot/H9H2F7 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/9103:STXBP3 ^@ http://purl.uniprot.org/uniprot/G1NEL2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9103:LOC104911020 ^@ http://purl.uniprot.org/uniprot/A0A803XXC3 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9103:LOC104914598 ^@ http://purl.uniprot.org/uniprot/H9H0H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9103:TTYH2 ^@ http://purl.uniprot.org/uniprot/G1N3Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9103:EIF2S2 ^@ http://purl.uniprot.org/uniprot/A0A803XYY6|||http://purl.uniprot.org/uniprot/A0A803YLQ2 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9103:ADGRL2 ^@ http://purl.uniprot.org/uniprot/A0A803Y8H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ACOT13 ^@ http://purl.uniprot.org/uniprot/G1N7H6 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9103:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A803YGH2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9103:GATA5 ^@ http://purl.uniprot.org/uniprot/G1N277 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:NSMCE1 ^@ http://purl.uniprot.org/uniprot/G1N4R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9103:SARAF ^@ http://purl.uniprot.org/uniprot/G3UPM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:SLC17A5 ^@ http://purl.uniprot.org/uniprot/G1NM26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GHITM ^@ http://purl.uniprot.org/uniprot/G3URU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9103:HMOX2 ^@ http://purl.uniprot.org/uniprot/G1NAF3 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9103:F7 ^@ http://purl.uniprot.org/uniprot/G1NPS2 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Heterodimer of a light chain and a heavy chain linked by a disulfide bond.|||Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:PTN ^@ http://purl.uniprot.org/uniprot/G1NKP6 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9103:LOC100541865 ^@ http://purl.uniprot.org/uniprot/A0A803Y2D4 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/9103:ADAMTS12 ^@ http://purl.uniprot.org/uniprot/A0A803XXJ5|||http://purl.uniprot.org/uniprot/A0A803Y2G6|||http://purl.uniprot.org/uniprot/G1NR24 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9103:PPP1R16B ^@ http://purl.uniprot.org/uniprot/G1MVT6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:GDPD5 ^@ http://purl.uniprot.org/uniprot/G3USK8 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9103:STK38L ^@ http://purl.uniprot.org/uniprot/G1NLV6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:KCNG2 ^@ http://purl.uniprot.org/uniprot/G1MTI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CREB3L3 ^@ http://purl.uniprot.org/uniprot/G1MUY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:PKNOX1 ^@ http://purl.uniprot.org/uniprot/G1NP19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9103:ATF7IP ^@ http://purl.uniprot.org/uniprot/G1NHB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9103:GRIA3 ^@ http://purl.uniprot.org/uniprot/G3UQQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9103:SYNGR3 ^@ http://purl.uniprot.org/uniprot/A0A803XVM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9103:G6PC2 ^@ http://purl.uniprot.org/uniprot/G1NDT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:CDC34 ^@ http://purl.uniprot.org/uniprot/G1MVS2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A803Y0T4 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9103:LOC100544391 ^@ http://purl.uniprot.org/uniprot/A0A803Y2Z9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:SUGP1 ^@ http://purl.uniprot.org/uniprot/A0A803Y043 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC104911970 ^@ http://purl.uniprot.org/uniprot/A0A803Y561 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/G1MXA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9103:STOML2 ^@ http://purl.uniprot.org/uniprot/A0A803XX28 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9103:KLHL15 ^@ http://purl.uniprot.org/uniprot/G1NP79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PSEN2 ^@ http://purl.uniprot.org/uniprot/G1N2Q5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9103:ENO2 ^@ http://purl.uniprot.org/uniprot/G1NMW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9103:LOC104914226 ^@ http://purl.uniprot.org/uniprot/A0A803YP43 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC104909720 ^@ http://purl.uniprot.org/uniprot/G1NEN7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:LGALS3 ^@ http://purl.uniprot.org/uniprot/G1NLL6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9103:SF3A1 ^@ http://purl.uniprot.org/uniprot/H9H083 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100548533 ^@ http://purl.uniprot.org/uniprot/G1NDP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9103:LEPROTL1 ^@ http://purl.uniprot.org/uniprot/G1N8V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9103:DUSP26 ^@ http://purl.uniprot.org/uniprot/G1MS40 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9103:PPP4R3B ^@ http://purl.uniprot.org/uniprot/G1MT71 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9103:TPH2 ^@ http://purl.uniprot.org/uniprot/G1NE85 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9103:CCND1 ^@ http://purl.uniprot.org/uniprot/G1NC37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/G1MTY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/9103:BORCS8 ^@ http://purl.uniprot.org/uniprot/G1MZ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:ABCB11 ^@ http://purl.uniprot.org/uniprot/G1NDS9 ^@ Subcellular Location Annotation ^@ Endosome http://togogenome.org/gene/9103:DDX3X ^@ http://purl.uniprot.org/uniprot/G1NP43 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9103:MEP1A ^@ http://purl.uniprot.org/uniprot/G1NN96 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:LOC100543474 ^@ http://purl.uniprot.org/uniprot/G1NDX0 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9103:LOC100544252 ^@ http://purl.uniprot.org/uniprot/A0A803YNR1|||http://purl.uniprot.org/uniprot/G1MSV1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9103:RBP7 ^@ http://purl.uniprot.org/uniprot/A0A803XZB3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9103:CAMKMT ^@ http://purl.uniprot.org/uniprot/G1NCX3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:DUSP5 ^@ http://purl.uniprot.org/uniprot/G1NEC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9103:PDCL ^@ http://purl.uniprot.org/uniprot/G1N7F4 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9103:CELF2 ^@ http://purl.uniprot.org/uniprot/A0A803Y057|||http://purl.uniprot.org/uniprot/A0A803Y5G9|||http://purl.uniprot.org/uniprot/A0A803YH30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:DNAJA1 ^@ http://purl.uniprot.org/uniprot/G1N266 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A803XUU4 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9103:CELF6 ^@ http://purl.uniprot.org/uniprot/A0A803XVX2|||http://purl.uniprot.org/uniprot/H9H0B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:A4GNT ^@ http://purl.uniprot.org/uniprot/G1MUG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9103:RAG1 ^@ http://purl.uniprot.org/uniprot/G1NRN5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/9103:FUT6 ^@ http://purl.uniprot.org/uniprot/G1NRK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9103:PTP4A1 ^@ http://purl.uniprot.org/uniprot/G1NM78 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9103:LOC100545074 ^@ http://purl.uniprot.org/uniprot/G1NCV7 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9103:NUTF2 ^@ http://purl.uniprot.org/uniprot/G1MUT4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9103:CDCA2 ^@ http://purl.uniprot.org/uniprot/G1MQ64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SMIM18 ^@ http://purl.uniprot.org/uniprot/A0A803XN25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ITGB8 ^@ http://purl.uniprot.org/uniprot/A0A803XU91|||http://purl.uniprot.org/uniprot/G1NFL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9103:DNAJC24 ^@ http://purl.uniprot.org/uniprot/G1MS41 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9103:HTR1D ^@ http://purl.uniprot.org/uniprot/G1NRI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:PIGV ^@ http://purl.uniprot.org/uniprot/H9H1L7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9103:UTS2 ^@ http://purl.uniprot.org/uniprot/G1MQH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9103:PPARGC1A ^@ http://purl.uniprot.org/uniprot/G1NIP7|||http://purl.uniprot.org/uniprot/G3X8N5 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9103:TRMT2B ^@ http://purl.uniprot.org/uniprot/G1NAL5 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:IL4I1 ^@ http://purl.uniprot.org/uniprot/B1N1B4 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9103:GJB1 ^@ http://purl.uniprot.org/uniprot/G1NSA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9103:ZER1 ^@ http://purl.uniprot.org/uniprot/G1MZK3 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9103:LOC723980 ^@ http://purl.uniprot.org/uniprot/G1MSZ9 ^@ Similarity ^@ Belongs to the avidin/streptavidin family. http://togogenome.org/gene/9103:LOC100543589 ^@ http://purl.uniprot.org/uniprot/A0A803XS83|||http://purl.uniprot.org/uniprot/G1MRG2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9103:SPRY2 ^@ http://purl.uniprot.org/uniprot/G1NRA2 ^@ Similarity ^@ Belongs to the sprouty family. http://togogenome.org/gene/9103:TCN2 ^@ http://purl.uniprot.org/uniprot/G1NNM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9103:LOC100549552 ^@ http://purl.uniprot.org/uniprot/G1NRH0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:FOPNL ^@ http://purl.uniprot.org/uniprot/G1N5L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||cilium basal body http://togogenome.org/gene/9103:GRP ^@ http://purl.uniprot.org/uniprot/A0A803YA32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||secretory vesicle lumen http://togogenome.org/gene/9103:LOC100546611 ^@ http://purl.uniprot.org/uniprot/G1MQ76 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9103:LOC100544587 ^@ http://purl.uniprot.org/uniprot/G1NK74 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9103:CHMP4C ^@ http://purl.uniprot.org/uniprot/G1NGL9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9103:SDC4 ^@ http://purl.uniprot.org/uniprot/Q5I5K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9103:ALOX5AP ^@ http://purl.uniprot.org/uniprot/G1NQB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:TDRD5 ^@ http://purl.uniprot.org/uniprot/A0A803Y0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm http://togogenome.org/gene/9103:MRPL53 ^@ http://purl.uniprot.org/uniprot/A0A803YFV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9103:RNFT2 ^@ http://purl.uniprot.org/uniprot/G1NCA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:NTRK3 ^@ http://purl.uniprot.org/uniprot/G1N9F1|||http://purl.uniprot.org/uniprot/G3UQB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9103:LOC100544620 ^@ http://purl.uniprot.org/uniprot/G1MRD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/9103:ABRACL ^@ http://purl.uniprot.org/uniprot/A0A803XP11 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/9103:LOC100543147 ^@ http://purl.uniprot.org/uniprot/G1N2E8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:LOC100544938 ^@ http://purl.uniprot.org/uniprot/H9H1X1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:ADRA1B ^@ http://purl.uniprot.org/uniprot/G1MVG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/9103:NEK8 ^@ http://purl.uniprot.org/uniprot/A0A803XL58 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9103:LOC100542432 ^@ http://purl.uniprot.org/uniprot/G1NIU0 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/9103:LOC104909218 ^@ http://purl.uniprot.org/uniprot/A0A803XRT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9103:LOC100545121 ^@ http://purl.uniprot.org/uniprot/G1NQZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9103:MYO1G ^@ http://purl.uniprot.org/uniprot/G1MVR9|||http://purl.uniprot.org/uniprot/G3UR39 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:LOC100550599 ^@ http://purl.uniprot.org/uniprot/G3UUX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:SMAD3 ^@ http://purl.uniprot.org/uniprot/G1NC09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:PICK1 ^@ http://purl.uniprot.org/uniprot/G1NIS1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/9103:SRMS ^@ http://purl.uniprot.org/uniprot/G1N3Z8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9103:SDC3 ^@ http://purl.uniprot.org/uniprot/Q5I5K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9103:AKAP1 ^@ http://purl.uniprot.org/uniprot/G1N886 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A803YR46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9103:SARM1 ^@ http://purl.uniprot.org/uniprot/G1N1Z8 ^@ Similarity ^@ Belongs to the SARM1 family. http://togogenome.org/gene/9103:NSG1 ^@ http://purl.uniprot.org/uniprot/G1NJA0 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9103:AIMP2 ^@ http://purl.uniprot.org/uniprot/G1MRL6 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9103:GPR20 ^@ http://purl.uniprot.org/uniprot/G1NRT8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:TCEANC ^@ http://purl.uniprot.org/uniprot/G1NPD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:AK4 ^@ http://purl.uniprot.org/uniprot/G1NH01 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/9103:BLCAP ^@ http://purl.uniprot.org/uniprot/G1NR85 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/9103:NOP58 ^@ http://purl.uniprot.org/uniprot/G1N828 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/9103:LOC100546659 ^@ http://purl.uniprot.org/uniprot/A0A803YR36 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9103:CRYBA1 ^@ http://purl.uniprot.org/uniprot/H9H1R5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9103:NOS1 ^@ http://purl.uniprot.org/uniprot/G1NC69 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.|||dendritic spine|||sarcolemma http://togogenome.org/gene/9103:MRPS17 ^@ http://purl.uniprot.org/uniprot/G1MYR0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9103:LOC100545434 ^@ http://purl.uniprot.org/uniprot/G1N1U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9103:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/G1NRQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9103:BMP4 ^@ http://purl.uniprot.org/uniprot/A0A803Y9A8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9103:IL17REL ^@ http://purl.uniprot.org/uniprot/G1N753 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:LRRC8A ^@ http://purl.uniprot.org/uniprot/G1MZK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:ABCC2 ^@ http://purl.uniprot.org/uniprot/G1NB22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:FOXO3 ^@ http://purl.uniprot.org/uniprot/G1NL82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:GPD1L ^@ http://purl.uniprot.org/uniprot/G1NFB1 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9103:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y956 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:APRT ^@ http://purl.uniprot.org/uniprot/G1N6T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/9103:CALCA ^@ http://purl.uniprot.org/uniprot/G1N4N0 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9103:PAQR8 ^@ http://purl.uniprot.org/uniprot/G1NRG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9103:GATA2 ^@ http://purl.uniprot.org/uniprot/G1N5I0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLC25A40 ^@ http://purl.uniprot.org/uniprot/G1N899 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:SARDH ^@ http://purl.uniprot.org/uniprot/G1N4I4 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9103:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A803Y1F7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9103:LOC100547911 ^@ http://purl.uniprot.org/uniprot/A0A803XW69 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9103:SLC35F6 ^@ http://purl.uniprot.org/uniprot/G1NMV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9103:INHA ^@ http://purl.uniprot.org/uniprot/Q98SQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9103:LOC100545512 ^@ http://purl.uniprot.org/uniprot/G1NL98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9103:P4HA1 ^@ http://purl.uniprot.org/uniprot/G1N1U2|||http://purl.uniprot.org/uniprot/G3UU74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9103:GPLD1 ^@ http://purl.uniprot.org/uniprot/G1MU37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9103:PICALM ^@ http://purl.uniprot.org/uniprot/A0A803XPW2 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/9103:RPS25 ^@ http://purl.uniprot.org/uniprot/G1MYC4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/9103:RXRG ^@ http://purl.uniprot.org/uniprot/A0A803Y8E2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9103:GSC ^@ http://purl.uniprot.org/uniprot/G1NKI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PARK7 ^@ http://purl.uniprot.org/uniprot/G1MQE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9103:CSTF1 ^@ http://purl.uniprot.org/uniprot/G1NAD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLC35A5 ^@ http://purl.uniprot.org/uniprot/G1NNF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9103:NPFFR1 ^@ http://purl.uniprot.org/uniprot/G1N157 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9103:RC3H2 ^@ http://purl.uniprot.org/uniprot/G1N7I5 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9103:ENPP4 ^@ http://purl.uniprot.org/uniprot/G1NN88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Cell membrane|||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|||Membrane http://togogenome.org/gene/9103:DTX1 ^@ http://purl.uniprot.org/uniprot/G1N1B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9103:HNF4A ^@ http://purl.uniprot.org/uniprot/G1MXX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:LOC100540504 ^@ http://purl.uniprot.org/uniprot/G1MUP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9103:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/G1NC30 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9103:MMP2 ^@ http://purl.uniprot.org/uniprot/Q6U7G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/9103:CER1 ^@ http://purl.uniprot.org/uniprot/G1N1X7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:DSE ^@ http://purl.uniprot.org/uniprot/G1NKZ7 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9103:KPNA4 ^@ http://purl.uniprot.org/uniprot/G1NDL2 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/9103:OGG1 ^@ http://purl.uniprot.org/uniprot/G1N8C7 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/9103:LOC100544088 ^@ http://purl.uniprot.org/uniprot/A0A803XPG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9103:CLUH ^@ http://purl.uniprot.org/uniprot/G1N917 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CLU family.|||Cytoplasm|||Cytoplasmic granule|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. http://togogenome.org/gene/9103:RAD17 ^@ http://purl.uniprot.org/uniprot/G1MTA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9103:LOC100542413 ^@ http://purl.uniprot.org/uniprot/G1NRH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:TRIM32 ^@ http://purl.uniprot.org/uniprot/G1MW22 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9103:TOB1 ^@ http://purl.uniprot.org/uniprot/G1N920 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9103:MRRF ^@ http://purl.uniprot.org/uniprot/A0A803YQ57 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9103:DAP3 ^@ http://purl.uniprot.org/uniprot/G1MQD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9103:LOC100544081 ^@ http://purl.uniprot.org/uniprot/G1MXM2 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9103:TRPV4 ^@ http://purl.uniprot.org/uniprot/G1N3R5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:AMOT ^@ http://purl.uniprot.org/uniprot/G1N3G8 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9103:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/G1N4I0 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9103:LOC100539035 ^@ http://purl.uniprot.org/uniprot/G1NEW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:GTF3C5 ^@ http://purl.uniprot.org/uniprot/G1N3C9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CELF1 ^@ http://purl.uniprot.org/uniprot/G1NDV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm http://togogenome.org/gene/9103:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A803XMJ1|||http://purl.uniprot.org/uniprot/G1MV95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic mitochondrial porin family.|||Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.|||Interacts with ARMC12 in a TBC1D21-dependent manner.|||Mitochondrion outer membrane http://togogenome.org/gene/9103:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/G1NCI5 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PJVK ^@ http://purl.uniprot.org/uniprot/G1NB24 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9103:F2 ^@ http://purl.uniprot.org/uniprot/G1NEM6 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/9103:SCNN1B ^@ http://purl.uniprot.org/uniprot/G1N4H6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/G1MXE9 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9103:LOC100542183 ^@ http://purl.uniprot.org/uniprot/G3UR00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:RSPH3 ^@ http://purl.uniprot.org/uniprot/G1NJR6 ^@ Similarity ^@ Belongs to the flagellar radial spoke RSP3 family. http://togogenome.org/gene/9103:PDE4C ^@ http://purl.uniprot.org/uniprot/A0A803Y1T7|||http://purl.uniprot.org/uniprot/A0A803YSS2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:LOC100540809 ^@ http://purl.uniprot.org/uniprot/A0A803XSG4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:MYOF ^@ http://purl.uniprot.org/uniprot/A0A803YE64|||http://purl.uniprot.org/uniprot/G1N9U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9103:KIF9 ^@ http://purl.uniprot.org/uniprot/A0A803XQP9|||http://purl.uniprot.org/uniprot/G1MVA1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:PRDX1 ^@ http://purl.uniprot.org/uniprot/G1NDB7 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9103:RAN ^@ http://purl.uniprot.org/uniprot/G1MTT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/9103:TAF2 ^@ http://purl.uniprot.org/uniprot/G3UUA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/9103:DCN ^@ http://purl.uniprot.org/uniprot/G1NFL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9103:NPL ^@ http://purl.uniprot.org/uniprot/G1MSX9 ^@ Similarity|||Subunit ^@ Belongs to the DapA family.|||Homotetramer. http://togogenome.org/gene/9103:LOC104913831 ^@ http://purl.uniprot.org/uniprot/G1NAP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CHST10 ^@ http://purl.uniprot.org/uniprot/G1NPL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:SLC39A12 ^@ http://purl.uniprot.org/uniprot/A0A803YE45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9103:HSDL1 ^@ http://purl.uniprot.org/uniprot/G1MQA6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:C1QA ^@ http://purl.uniprot.org/uniprot/G1N3Y0 ^@ Function ^@ C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. http://togogenome.org/gene/9103:SCOC ^@ http://purl.uniprot.org/uniprot/G1MVB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9103:MANEA ^@ http://purl.uniprot.org/uniprot/G1NLI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:RPL7 ^@ http://purl.uniprot.org/uniprot/G1NG55 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9103:LOC100547252 ^@ http://purl.uniprot.org/uniprot/G1U9Q8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:MEOX2 ^@ http://purl.uniprot.org/uniprot/G1NCH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLA ^@ http://purl.uniprot.org/uniprot/G1NJM3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:CAPN15 ^@ http://purl.uniprot.org/uniprot/G1NCL4 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:NDUFV3 ^@ http://purl.uniprot.org/uniprot/G1NP18 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9103:CPT1A ^@ http://purl.uniprot.org/uniprot/G1NAY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9103:LOC100539008 ^@ http://purl.uniprot.org/uniprot/G1MTV2 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/9103:CASKIN2 ^@ http://purl.uniprot.org/uniprot/A0A803XKY5|||http://purl.uniprot.org/uniprot/A0A803XZX1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:LOC723981 ^@ http://purl.uniprot.org/uniprot/Q71SZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:AP3B2 ^@ http://purl.uniprot.org/uniprot/A0A803XMK6|||http://purl.uniprot.org/uniprot/A0A803YEZ2|||http://purl.uniprot.org/uniprot/A0A803YN04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9103:GOLPH3L ^@ http://purl.uniprot.org/uniprot/G1MPZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:PLCB2 ^@ http://purl.uniprot.org/uniprot/Q91086 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9103:PTP4A2 ^@ http://purl.uniprot.org/uniprot/G1MZA9 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9103:LOC100547540 ^@ http://purl.uniprot.org/uniprot/G1N9M0 ^@ Similarity|||Subunit ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9103:CHMP1A ^@ http://purl.uniprot.org/uniprot/G1N7T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF7 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9103:NTN4 ^@ http://purl.uniprot.org/uniprot/G1NG05 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:SPP2 ^@ http://purl.uniprot.org/uniprot/G1MUJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Secreted http://togogenome.org/gene/9103:LRP8 ^@ http://purl.uniprot.org/uniprot/A0A803XSU4|||http://purl.uniprot.org/uniprot/G1NFK8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:GNB4 ^@ http://purl.uniprot.org/uniprot/G1MU86 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9103:LOC100543299 ^@ http://purl.uniprot.org/uniprot/G1NDF8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9103:PRLR ^@ http://purl.uniprot.org/uniprot/Q91094 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9103:SLC25A39 ^@ http://purl.uniprot.org/uniprot/G1MRQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:LOC100541781 ^@ http://purl.uniprot.org/uniprot/G1NH10 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y7M2 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9103:MC3R ^@ http://purl.uniprot.org/uniprot/G1NRA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9103:APLP2 ^@ http://purl.uniprot.org/uniprot/G1MQW1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:CHEK1 ^@ http://purl.uniprot.org/uniprot/H9H052 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9103:SEPHS1 ^@ http://purl.uniprot.org/uniprot/G1N034 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9103:TINAG ^@ http://purl.uniprot.org/uniprot/G1NMB6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9103:ARCN1 ^@ http://purl.uniprot.org/uniprot/G1MXG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9103:LOC100542248 ^@ http://purl.uniprot.org/uniprot/G1N0J9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9103:BPGM ^@ http://purl.uniprot.org/uniprot/G1NLB3 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9103:AGPAT2 ^@ http://purl.uniprot.org/uniprot/G1N678 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9103:PSMG1 ^@ http://purl.uniprot.org/uniprot/G1NNZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.|||Cytoplasm|||Forms a heterodimer with psmg2. http://togogenome.org/gene/9103:SRC ^@ http://purl.uniprot.org/uniprot/G1MWN3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9103:CTNND1 ^@ http://purl.uniprot.org/uniprot/G1NBL8|||http://purl.uniprot.org/uniprot/G3URR3 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9103:POT1 ^@ http://purl.uniprot.org/uniprot/G5E7N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9103:AP2M1 ^@ http://purl.uniprot.org/uniprot/G1N9V3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9103:VDAC2 ^@ http://purl.uniprot.org/uniprot/G3X8N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Mitochondrion outer membrane http://togogenome.org/gene/9103:CLDN19 ^@ http://purl.uniprot.org/uniprot/G1N4W5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A803XTX8|||http://purl.uniprot.org/uniprot/A0A803Y5N3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Nucleus|||Synapse http://togogenome.org/gene/9103:MACIR ^@ http://purl.uniprot.org/uniprot/G1NS33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9103:LOC100544899 ^@ http://purl.uniprot.org/uniprot/G1N1U5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||cilium membrane http://togogenome.org/gene/9103:TRAK2 ^@ http://purl.uniprot.org/uniprot/G1N7B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9103:DOHH ^@ http://purl.uniprot.org/uniprot/G1MRT1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/9103:PATL2 ^@ http://purl.uniprot.org/uniprot/G1MRG0 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9103:AP1S2 ^@ http://purl.uniprot.org/uniprot/G1NPB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9103:TNMD ^@ http://purl.uniprot.org/uniprot/G1MYQ6 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9103:LOC100548057 ^@ http://purl.uniprot.org/uniprot/A0A803YIR2|||http://purl.uniprot.org/uniprot/G1MXJ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9103:DRAXIN ^@ http://purl.uniprot.org/uniprot/G1N3M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.|||Secreted http://togogenome.org/gene/9103:LOC100545462 ^@ http://purl.uniprot.org/uniprot/G1MWV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9103:LIN54 ^@ http://purl.uniprot.org/uniprot/G1N7C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9103:SLC35B4 ^@ http://purl.uniprot.org/uniprot/G1MX80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9103:ABHD2 ^@ http://purl.uniprot.org/uniprot/G1N922 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9103:PPIL6 ^@ http://purl.uniprot.org/uniprot/G1NL67 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9103:ZNF592 ^@ http://purl.uniprot.org/uniprot/G1MQJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9103:AGTR2 ^@ http://purl.uniprot.org/uniprot/G1NRP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9103:FOXL3 ^@ http://purl.uniprot.org/uniprot/G3UV78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PRPF4 ^@ http://purl.uniprot.org/uniprot/G1MSK8 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9103:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A803XQD2|||http://purl.uniprot.org/uniprot/G1NED8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9103:DPH5 ^@ http://purl.uniprot.org/uniprot/G1N4Q3 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9103:CNTF ^@ http://purl.uniprot.org/uniprot/G1NBP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9103:CCR6 ^@ http://purl.uniprot.org/uniprot/G1NRR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9103:TXLNB ^@ http://purl.uniprot.org/uniprot/G1NL02 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9103:PROS1 ^@ http://purl.uniprot.org/uniprot/G1NNL9 ^@ Caution|||Function ^@ Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:IL18R1 ^@ http://purl.uniprot.org/uniprot/G1NPN1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9103:LOC100550421 ^@ http://purl.uniprot.org/uniprot/G1NED2 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9103:THPO ^@ http://purl.uniprot.org/uniprot/G1NA01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9103:TIRAP ^@ http://purl.uniprot.org/uniprot/A0A803XKY1|||http://purl.uniprot.org/uniprot/G1MQ01|||http://purl.uniprot.org/uniprot/G1MQ03 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.|||Cell membrane|||Cytoplasm|||Homodimer.|||Membrane http://togogenome.org/gene/9103:PSMB1 ^@ http://purl.uniprot.org/uniprot/G1NHW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A803Y0X9|||http://purl.uniprot.org/uniprot/A0A803Y1W9|||http://purl.uniprot.org/uniprot/H9H1S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PEX12 ^@ http://purl.uniprot.org/uniprot/G1MYA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Peroxisome membrane|||Required for protein import into peroxisomes. http://togogenome.org/gene/9103:TNFRSF6B ^@ http://purl.uniprot.org/uniprot/G1N4U8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PRDM10 ^@ http://purl.uniprot.org/uniprot/A0A803XUQ4|||http://purl.uniprot.org/uniprot/A0A803XV35 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9103:BMPR1B ^@ http://purl.uniprot.org/uniprot/G1NF29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9103:LOC100543527 ^@ http://purl.uniprot.org/uniprot/G1N619 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:EEF1A1 ^@ http://purl.uniprot.org/uniprot/G1NM38 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9103:MYCL ^@ http://purl.uniprot.org/uniprot/G1N1S7 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9103:CZH5orf63 ^@ http://purl.uniprot.org/uniprot/A0A803YPF3 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9103:LOC100539852 ^@ http://purl.uniprot.org/uniprot/G1NRX3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:FAIM2 ^@ http://purl.uniprot.org/uniprot/G1NF76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9103:LIG4 ^@ http://purl.uniprot.org/uniprot/G1NR93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9103:MAP2K3 ^@ http://purl.uniprot.org/uniprot/G1MYN0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:PI4KA ^@ http://purl.uniprot.org/uniprot/G1MQF7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9103:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A803XUD1|||http://purl.uniprot.org/uniprot/G1MVK6 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9103:PNPLA4 ^@ http://purl.uniprot.org/uniprot/G1NPF1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:ND2 ^@ http://purl.uniprot.org/uniprot/Q955U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100545607 ^@ http://purl.uniprot.org/uniprot/G1N363 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9103:WNT3 ^@ http://purl.uniprot.org/uniprot/G3UQW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9103:COG2 ^@ http://purl.uniprot.org/uniprot/G1NHM9 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9103:MFAP3 ^@ http://purl.uniprot.org/uniprot/G3UPP7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:NMD3 ^@ http://purl.uniprot.org/uniprot/G1NDH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CDCA7L ^@ http://purl.uniprot.org/uniprot/G5E7K9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:DLK1 ^@ http://purl.uniprot.org/uniprot/B3VL40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC104914008 ^@ http://purl.uniprot.org/uniprot/A0A803Y277 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/9103:GEMIN2 ^@ http://purl.uniprot.org/uniprot/G1NIW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. http://togogenome.org/gene/9103:HSPA8 ^@ http://purl.uniprot.org/uniprot/G1MSW3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9103:MPI ^@ http://purl.uniprot.org/uniprot/G1MTS9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9103:HEBP1 ^@ http://purl.uniprot.org/uniprot/G1NH27 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9103:LOC100550291 ^@ http://purl.uniprot.org/uniprot/A0A803XT57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9103:LOC100549463 ^@ http://purl.uniprot.org/uniprot/G1NDI9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:GTF2B ^@ http://purl.uniprot.org/uniprot/A0A803Y749 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9103:TAF1D ^@ http://purl.uniprot.org/uniprot/G1NQN5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9103:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/G1NAY8 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9103:HDAC3 ^@ http://purl.uniprot.org/uniprot/G1MT85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9103:MASP2 ^@ http://purl.uniprot.org/uniprot/G1MZH7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:C11H18orf32 ^@ http://purl.uniprot.org/uniprot/G1MRG6 ^@ Similarity ^@ Belongs to the UPF0729 family. http://togogenome.org/gene/9103:C5H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A803YBW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||centriolar satellite http://togogenome.org/gene/9103:LOC100546881 ^@ http://purl.uniprot.org/uniprot/G1MZJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9103:CAVIN1 ^@ http://purl.uniprot.org/uniprot/G1MWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9103:CHRNA1 ^@ http://purl.uniprot.org/uniprot/G1NBR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:C8B ^@ http://purl.uniprot.org/uniprot/G1NG42 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:IL12A ^@ http://purl.uniprot.org/uniprot/G1NDR2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/9103:GAREM1 ^@ http://purl.uniprot.org/uniprot/G1NDS3 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9103:ADAM19 ^@ http://purl.uniprot.org/uniprot/G1N0L1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:UGP2 ^@ http://purl.uniprot.org/uniprot/G1N004 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9103:TSPAN14 ^@ http://purl.uniprot.org/uniprot/G1MQL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9103:SLC25A19 ^@ http://purl.uniprot.org/uniprot/A0A803XKU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:FGG ^@ http://purl.uniprot.org/uniprot/G1MRP5 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9103:LOC100540595 ^@ http://purl.uniprot.org/uniprot/G3USS3 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9103:FAM234A ^@ http://purl.uniprot.org/uniprot/G1N9Q1 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9103:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/G1NBB9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:DOK2 ^@ http://purl.uniprot.org/uniprot/A0A803XWP6|||http://purl.uniprot.org/uniprot/A0A803YK17 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9103:LOC104917567 ^@ http://purl.uniprot.org/uniprot/G1NQ90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CEP170B ^@ http://purl.uniprot.org/uniprot/A0A803XZJ5|||http://purl.uniprot.org/uniprot/G1NL58 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/9103:CMAS ^@ http://purl.uniprot.org/uniprot/G1NLN5 ^@ Similarity ^@ Belongs to the CMP-NeuNAc synthase family. http://togogenome.org/gene/9103:CX3CR1 ^@ http://purl.uniprot.org/uniprot/G1NS66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9103:SOST ^@ http://purl.uniprot.org/uniprot/A0A803YRN3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the sclerostin family.|||Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. http://togogenome.org/gene/9103:LOC100551396 ^@ http://purl.uniprot.org/uniprot/H9H1Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9103:ASPH ^@ http://purl.uniprot.org/uniprot/A0A803Y3B3|||http://purl.uniprot.org/uniprot/A0A803Y653|||http://purl.uniprot.org/uniprot/A0A803Y6V7|||http://purl.uniprot.org/uniprot/A0A803YF48|||http://purl.uniprot.org/uniprot/A0A803YRZ2|||http://purl.uniprot.org/uniprot/G1NF71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family.|||Membrane http://togogenome.org/gene/9103:MAPK9 ^@ http://purl.uniprot.org/uniprot/G1N6G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9103:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A803YS46 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:GIP ^@ http://purl.uniprot.org/uniprot/G1N5G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/9103:NSMCE4A ^@ http://purl.uniprot.org/uniprot/G1NG53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/9103:HAPLN4 ^@ http://purl.uniprot.org/uniprot/G1MYU0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:BDKRB1 ^@ http://purl.uniprot.org/uniprot/G1NR13 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9103:LOC109367730 ^@ http://purl.uniprot.org/uniprot/A0A803YF62 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9103:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A803YDU9|||http://purl.uniprot.org/uniprot/G1NLN2 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/9103:TCP1 ^@ http://purl.uniprot.org/uniprot/G1NIP3 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/9103:LOC100545586 ^@ http://purl.uniprot.org/uniprot/G1N0Z2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PTGES2 ^@ http://purl.uniprot.org/uniprot/A0A803YS56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/9103:LOC100548588 ^@ http://purl.uniprot.org/uniprot/A0A803XLR1|||http://purl.uniprot.org/uniprot/A0A803XWR9|||http://purl.uniprot.org/uniprot/G1NN67 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:UNC5B ^@ http://purl.uniprot.org/uniprot/G3UUH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9103:SETD2 ^@ http://purl.uniprot.org/uniprot/G1MV76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100542776 ^@ http://purl.uniprot.org/uniprot/G1NNG8 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9103:LOC100538367 ^@ http://purl.uniprot.org/uniprot/G1NKG9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:MID1 ^@ http://purl.uniprot.org/uniprot/A0A803XQ03 ^@ Function|||Subcellular Location Annotation ^@ Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.|||cytoskeleton http://togogenome.org/gene/9103:DPCD ^@ http://purl.uniprot.org/uniprot/G1NCK4 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9103:RAB38 ^@ http://purl.uniprot.org/uniprot/G1NQP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9103:PITRM1 ^@ http://purl.uniprot.org/uniprot/A0A803YNA9 ^@ Subunit ^@ Monomer and homodimer; homodimerization is induced by binding of the substrate. http://togogenome.org/gene/9103:USP14 ^@ http://purl.uniprot.org/uniprot/A0A803XZ58 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9103:VIRMA ^@ http://purl.uniprot.org/uniprot/G1NHI1 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9103:DLGAP3 ^@ http://purl.uniprot.org/uniprot/G1MYN7 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9103:RHO ^@ http://purl.uniprot.org/uniprot/G1ND14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9103:SYPL1 ^@ http://purl.uniprot.org/uniprot/G1N4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9103:SEMA6A ^@ http://purl.uniprot.org/uniprot/A0A803XSM9|||http://purl.uniprot.org/uniprot/A0A803YJY8|||http://purl.uniprot.org/uniprot/A0A803YLW7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:MTMR6 ^@ http://purl.uniprot.org/uniprot/G1NQE1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9103:LOC100541404 ^@ http://purl.uniprot.org/uniprot/G1N4U2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9103:EIF3A ^@ http://purl.uniprot.org/uniprot/G1NFM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/9103:PIGW ^@ http://purl.uniprot.org/uniprot/G1NR72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9103:SGSM2 ^@ http://purl.uniprot.org/uniprot/A0A803XLP3|||http://purl.uniprot.org/uniprot/G1N8X1 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9103:UTP11 ^@ http://purl.uniprot.org/uniprot/G1MV44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9103:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A803XWE8|||http://purl.uniprot.org/uniprot/A0A803XXZ7|||http://purl.uniprot.org/uniprot/G1NMG1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:ADGRA2 ^@ http://purl.uniprot.org/uniprot/G1MSS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9103:SLC20A2 ^@ http://purl.uniprot.org/uniprot/G1MZC9|||http://purl.uniprot.org/uniprot/G3UTR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/9103:SLC29A4 ^@ http://purl.uniprot.org/uniprot/A0A803XMH3|||http://purl.uniprot.org/uniprot/G1MXN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9103:APAF1 ^@ http://purl.uniprot.org/uniprot/A0A803YDJ7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/9103:SEMA3E ^@ http://purl.uniprot.org/uniprot/G1N1I1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A803XS28|||http://purl.uniprot.org/uniprot/G1NN08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/9103:RHCG ^@ http://purl.uniprot.org/uniprot/G1N8P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9103:SEC61G ^@ http://purl.uniprot.org/uniprot/G1NIC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:POMGNT1 ^@ http://purl.uniprot.org/uniprot/G1NDR4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/9103:LOC100550016 ^@ http://purl.uniprot.org/uniprot/G1NHE1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9103:TNC ^@ http://purl.uniprot.org/uniprot/A0A803XY97|||http://purl.uniprot.org/uniprot/A0A803YGC0|||http://purl.uniprot.org/uniprot/A0A803YK94|||http://purl.uniprot.org/uniprot/G1MVR6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9103:SLC25A38 ^@ http://purl.uniprot.org/uniprot/G1NGU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:DDO ^@ http://purl.uniprot.org/uniprot/A0A803Y2V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9103:TOP2B ^@ http://purl.uniprot.org/uniprot/G1NF24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9103:CFAP97 ^@ http://purl.uniprot.org/uniprot/G1N3B1 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9103:CTPS2 ^@ http://purl.uniprot.org/uniprot/G1NPB4 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9103:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A803YKZ3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9103:RPS3 ^@ http://purl.uniprot.org/uniprot/A0A803XL13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||nucleolus|||spindle http://togogenome.org/gene/9103:CTSB ^@ http://purl.uniprot.org/uniprot/G1NN37 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9103:HAO2 ^@ http://purl.uniprot.org/uniprot/G1NN50 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9103:KCNT1 ^@ http://purl.uniprot.org/uniprot/G1MWB2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:IP6K1 ^@ http://purl.uniprot.org/uniprot/G1MVY4 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9103:LOC100546401 ^@ http://purl.uniprot.org/uniprot/A0A803Y843 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/9103:PLAT ^@ http://purl.uniprot.org/uniprot/G1MVL1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:CCNG1 ^@ http://purl.uniprot.org/uniprot/G1MUL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin G subfamily.|||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.|||Nucleus http://togogenome.org/gene/9103:EWSR1 ^@ http://purl.uniprot.org/uniprot/G1N180 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9103:DSP ^@ http://purl.uniprot.org/uniprot/G1MXH6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9103:F13A1 ^@ http://purl.uniprot.org/uniprot/G1MXW0 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9103:IRF4 ^@ http://purl.uniprot.org/uniprot/G1MYY4|||http://purl.uniprot.org/uniprot/G3URE6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:KATNAL1 ^@ http://purl.uniprot.org/uniprot/G1NQC0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9103:SLC35A1 ^@ http://purl.uniprot.org/uniprot/G1NLP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9103:USP15 ^@ http://purl.uniprot.org/uniprot/A0A803XU98|||http://purl.uniprot.org/uniprot/G1NCJ5|||http://purl.uniprot.org/uniprot/G5E7M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:FEN1 ^@ http://purl.uniprot.org/uniprot/G1NRM5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9103:SLC13A3 ^@ http://purl.uniprot.org/uniprot/G1MYF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9103:LOC100543487 ^@ http://purl.uniprot.org/uniprot/G3UQC5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9103:RARS2 ^@ http://purl.uniprot.org/uniprot/G1NLP0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9103:INSIG2 ^@ http://purl.uniprot.org/uniprot/G3UQT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9103:TUBD1 ^@ http://purl.uniprot.org/uniprot/G1N664 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9103:HSPB7 ^@ http://purl.uniprot.org/uniprot/G1N0N8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9103:SLC2A2 ^@ http://purl.uniprot.org/uniprot/G1NCQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SLC4A11 ^@ http://purl.uniprot.org/uniprot/A0A803XRA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/9103:UBE4A ^@ http://purl.uniprot.org/uniprot/G1MV60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/9103:UNC5D ^@ http://purl.uniprot.org/uniprot/G1MSM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9103:LOC104914182 ^@ http://purl.uniprot.org/uniprot/G1N3E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9103:LOC100551374 ^@ http://purl.uniprot.org/uniprot/G1N787 ^@ Similarity ^@ Belongs to the DNA photolyase class-2 family. http://togogenome.org/gene/9103:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A803Y336|||http://purl.uniprot.org/uniprot/A0A803YQB1|||http://purl.uniprot.org/uniprot/G1NAZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9103:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/G1N923 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/9103:LOC100550045 ^@ http://purl.uniprot.org/uniprot/G1NRB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9103:KCNJ16 ^@ http://purl.uniprot.org/uniprot/G1N4D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9103:MAPK8 ^@ http://purl.uniprot.org/uniprot/G1N7L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9103:CD47 ^@ http://purl.uniprot.org/uniprot/A0A803XL87|||http://purl.uniprot.org/uniprot/G1NNJ4|||http://purl.uniprot.org/uniprot/G1NNK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:ATAD1 ^@ http://purl.uniprot.org/uniprot/G1MS20 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9103:ENTPD5 ^@ http://purl.uniprot.org/uniprot/G1NJ21 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9103:AQP8 ^@ http://purl.uniprot.org/uniprot/G1N3T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9103:ARHGDIB ^@ http://purl.uniprot.org/uniprot/G1NGY1 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9103:ND1 ^@ http://purl.uniprot.org/uniprot/A9XBD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:GALT ^@ http://purl.uniprot.org/uniprot/A0A803YHK7 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9103:YPEL1 ^@ http://purl.uniprot.org/uniprot/G1MQU3 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9103:YME1L1 ^@ http://purl.uniprot.org/uniprot/G1N4J3 ^@ Similarity ^@ Belongs to the AAA ATPase family.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9103:LOC100546469 ^@ http://purl.uniprot.org/uniprot/G1MRQ1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9103:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A803YM94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/9103:LOC100546708 ^@ http://purl.uniprot.org/uniprot/G1NKP8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:DERL1 ^@ http://purl.uniprot.org/uniprot/G1NIY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9103:SLITRK1 ^@ http://purl.uniprot.org/uniprot/G1NR99 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9103:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A803Y2J3|||http://purl.uniprot.org/uniprot/G1N8Q6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:BCDIN3D ^@ http://purl.uniprot.org/uniprot/A0A803XSA0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9103:TYRP1 ^@ http://purl.uniprot.org/uniprot/G1N1Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/9103:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A803XNB6|||http://purl.uniprot.org/uniprot/A0A803YBC7|||http://purl.uniprot.org/uniprot/G1N9H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9103:DBH ^@ http://purl.uniprot.org/uniprot/G1N4E9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Conversion of dopamine to noradrenaline.|||Homotetramer; composed of two disulfide-linked dimers.|||chromaffin granule lumen|||chromaffin granule membrane|||secretory vesicle lumen|||secretory vesicle membrane http://togogenome.org/gene/9103:ATP6V1A ^@ http://purl.uniprot.org/uniprot/G1NN61 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/9103:NTHL1 ^@ http://purl.uniprot.org/uniprot/G1N2F0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9103:MYMK ^@ http://purl.uniprot.org/uniprot/G1N4Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:HTR1E ^@ http://purl.uniprot.org/uniprot/G1NRW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:TMEM229B ^@ http://purl.uniprot.org/uniprot/G1NRP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9103:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/G1NAV4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9103:SEC22C ^@ http://purl.uniprot.org/uniprot/G1MTR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9103:TF ^@ http://purl.uniprot.org/uniprot/Q53HY1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/9103:SLX4 ^@ http://purl.uniprot.org/uniprot/G1NAH3 ^@ Similarity ^@ Belongs to the SLX4 family. http://togogenome.org/gene/9103:SEC11C ^@ http://purl.uniprot.org/uniprot/G1MR20 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:FGA ^@ http://purl.uniprot.org/uniprot/G1MRL1 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9103:POLL ^@ http://purl.uniprot.org/uniprot/G1NCL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus http://togogenome.org/gene/9103:FAM124B ^@ http://purl.uniprot.org/uniprot/G1N0E1 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9103:GJA1 ^@ http://purl.uniprot.org/uniprot/G1NKU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9103:SLC12A9 ^@ http://purl.uniprot.org/uniprot/G1N8B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9103:TTLL1 ^@ http://purl.uniprot.org/uniprot/G1NLX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin polyglutamylase family.|||cilium basal body http://togogenome.org/gene/9103:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A803YD73|||http://purl.uniprot.org/uniprot/H9H1L2 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9103:LOC100541523 ^@ http://purl.uniprot.org/uniprot/A0A803YFD3 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9103:INO80 ^@ http://purl.uniprot.org/uniprot/G1NF95 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/9103:KCNS1 ^@ http://purl.uniprot.org/uniprot/G1MWS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TMPRSS6 ^@ http://purl.uniprot.org/uniprot/G1NJ34 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:CDH2 ^@ http://purl.uniprot.org/uniprot/G1NDC6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GALR2 ^@ http://purl.uniprot.org/uniprot/G1MYR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:DIO1 ^@ http://purl.uniprot.org/uniprot/M9P2D6 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/9103:TDRD9 ^@ http://purl.uniprot.org/uniprot/A0A803XNL6|||http://purl.uniprot.org/uniprot/G1NL37 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/9103:NFYA ^@ http://purl.uniprot.org/uniprot/G1NCN2|||http://purl.uniprot.org/uniprot/G3X8L7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9103:TJAP1 ^@ http://purl.uniprot.org/uniprot/A0A803XUQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:STAR ^@ http://purl.uniprot.org/uniprot/G1MTF0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9103:GNB5 ^@ http://purl.uniprot.org/uniprot/A0A803YG17 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9103:MIS12 ^@ http://purl.uniprot.org/uniprot/G3UT65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/9103:LOC100549326 ^@ http://purl.uniprot.org/uniprot/A0A803Y0F3|||http://purl.uniprot.org/uniprot/G1NET6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9103:FMOD ^@ http://purl.uniprot.org/uniprot/G1NAU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.|||Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to type I and type II collagen.|||extracellular matrix http://togogenome.org/gene/9103:PDP2 ^@ http://purl.uniprot.org/uniprot/G1NRD6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9103:CAPN7 ^@ http://purl.uniprot.org/uniprot/G1NFR6 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:MBOAT1 ^@ http://purl.uniprot.org/uniprot/G1MUH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A803Y2N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9103:RAB32 ^@ http://purl.uniprot.org/uniprot/G1NIV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9103:VASN ^@ http://purl.uniprot.org/uniprot/G1NAX4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100544448 ^@ http://purl.uniprot.org/uniprot/G1N558 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:LOC100539048 ^@ http://purl.uniprot.org/uniprot/G1N2Z8 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9103:LOC104913658 ^@ http://purl.uniprot.org/uniprot/G1MTP8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9103:LOC100549268 ^@ http://purl.uniprot.org/uniprot/M1ZMK0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9103:PAQR3 ^@ http://purl.uniprot.org/uniprot/G1N5X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9103:RTRAF ^@ http://purl.uniprot.org/uniprot/G1NLZ3 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9103:CCL20 ^@ http://purl.uniprot.org/uniprot/G1N2K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9103:SLC46A3 ^@ http://purl.uniprot.org/uniprot/G1NQC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:MFSD10 ^@ http://purl.uniprot.org/uniprot/G1NJZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PTGES ^@ http://purl.uniprot.org/uniprot/A0A803XUI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9103:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A803Y3V5|||http://purl.uniprot.org/uniprot/G1MSJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A803XTZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/9103:LOC100547276 ^@ http://purl.uniprot.org/uniprot/A0A803XMI0|||http://purl.uniprot.org/uniprot/G1N1P8 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9103:LOC100539142 ^@ http://purl.uniprot.org/uniprot/G1MUE2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9103:PLEKHO1 ^@ http://purl.uniprot.org/uniprot/G1MPR5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:MYCBP ^@ http://purl.uniprot.org/uniprot/G1MV16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/9103:SELENBP1 ^@ http://purl.uniprot.org/uniprot/G1MR11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9103:SRPRA ^@ http://purl.uniprot.org/uniprot/G1MPZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:STX6 ^@ http://purl.uniprot.org/uniprot/A0A803Y3N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9103:GNG4 ^@ http://purl.uniprot.org/uniprot/G1NH37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9103:TAFA1 ^@ http://purl.uniprot.org/uniprot/A0A803Y8W6|||http://purl.uniprot.org/uniprot/G1NAQ2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9103:AXIN1 ^@ http://purl.uniprot.org/uniprot/G1N9T5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/9103:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A803XRM9|||http://purl.uniprot.org/uniprot/A0A803XU49 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9103:POPDC2 ^@ http://purl.uniprot.org/uniprot/G1NNA5 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9103:PREP ^@ http://purl.uniprot.org/uniprot/G1NLB6 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9103:LOC104913819 ^@ http://purl.uniprot.org/uniprot/G1N8S9 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9103:IFNAR2 ^@ http://purl.uniprot.org/uniprot/A0A803YJ79|||http://purl.uniprot.org/uniprot/G1NNW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/9103:LOC100538554 ^@ http://purl.uniprot.org/uniprot/G1N1L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/9103:GTPBP4 ^@ http://purl.uniprot.org/uniprot/H9H2L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9103:HDC ^@ http://purl.uniprot.org/uniprot/A0A803YD44|||http://purl.uniprot.org/uniprot/G1N6G5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9103:NDUFA1 ^@ http://purl.uniprot.org/uniprot/G1N6V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:NKX2-8 ^@ http://purl.uniprot.org/uniprot/G1NIS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100549877 ^@ http://purl.uniprot.org/uniprot/G1MZ38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:CPLX3 ^@ http://purl.uniprot.org/uniprot/G1MU08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9103:DIS3L2 ^@ http://purl.uniprot.org/uniprot/G1N815 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/9103:NUP155 ^@ http://purl.uniprot.org/uniprot/G1MWF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9103:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A803YFQ5|||http://purl.uniprot.org/uniprot/G1NLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/9103:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A803YBP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100551099 ^@ http://purl.uniprot.org/uniprot/G1MWA9 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9103:ATP10A ^@ http://purl.uniprot.org/uniprot/G1NPJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9103:LOC104914672 ^@ http://purl.uniprot.org/uniprot/G1MSU4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:CRLS1 ^@ http://purl.uniprot.org/uniprot/G1N6X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9103:CACNG4 ^@ http://purl.uniprot.org/uniprot/G1N644 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/9103:SLC25A25 ^@ http://purl.uniprot.org/uniprot/G1MWW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ALB ^@ http://purl.uniprot.org/uniprot/G1NCR2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:RO60 ^@ http://purl.uniprot.org/uniprot/G1N1G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9103:ESCO2 ^@ http://purl.uniprot.org/uniprot/A0A803YJI3|||http://purl.uniprot.org/uniprot/G1NMV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:FOXP1 ^@ http://purl.uniprot.org/uniprot/G1NB92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:COPE ^@ http://purl.uniprot.org/uniprot/G1MZN3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. http://togogenome.org/gene/9103:MFNG ^@ http://purl.uniprot.org/uniprot/A0A803Y789 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:RETREG1 ^@ http://purl.uniprot.org/uniprot/G1N229 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane http://togogenome.org/gene/9103:MTMR1 ^@ http://purl.uniprot.org/uniprot/A0A803XYR2|||http://purl.uniprot.org/uniprot/A0A803Y0Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9103:RBBP7 ^@ http://purl.uniprot.org/uniprot/G1NPB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:RAE1 ^@ http://purl.uniprot.org/uniprot/G1NA63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat rae1 family.|||spindle pole http://togogenome.org/gene/9103:LOC100544064 ^@ http://purl.uniprot.org/uniprot/G3UR26 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PDE6D ^@ http://purl.uniprot.org/uniprot/G1N7Y3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9103:CETN2 ^@ http://purl.uniprot.org/uniprot/G1N1G4 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9103:ECRG4 ^@ http://purl.uniprot.org/uniprot/G1NPP2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9103:RYBP ^@ http://purl.uniprot.org/uniprot/G1NBE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:TMEM168 ^@ http://purl.uniprot.org/uniprot/G1NA55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane http://togogenome.org/gene/9103:SERPINA10 ^@ http://purl.uniprot.org/uniprot/G1NKG8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:MGAT5 ^@ http://purl.uniprot.org/uniprot/G1NII7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9103:LOC100543260 ^@ http://purl.uniprot.org/uniprot/G1MUV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:SLC28A3 ^@ http://purl.uniprot.org/uniprot/A0A803Y9U5|||http://purl.uniprot.org/uniprot/A0A803YBZ0|||http://purl.uniprot.org/uniprot/A0A803YKM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9103:EIF5 ^@ http://purl.uniprot.org/uniprot/G1NL07 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/9103:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A803XS57|||http://purl.uniprot.org/uniprot/A0A803XSI3|||http://purl.uniprot.org/uniprot/A0A803Y9J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9103:LOC100547253 ^@ http://purl.uniprot.org/uniprot/A0A803XQ74 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:CLPTM1L ^@ http://purl.uniprot.org/uniprot/G1N5Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9103:CDC123 ^@ http://purl.uniprot.org/uniprot/G1MZG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9103:SLC5A11 ^@ http://purl.uniprot.org/uniprot/A0A803YBP2|||http://purl.uniprot.org/uniprot/G1N3J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9103:AP2A2 ^@ http://purl.uniprot.org/uniprot/G3UQ35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/9103:LOC100550477 ^@ http://purl.uniprot.org/uniprot/G1N6D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Membrane http://togogenome.org/gene/9103:EBNA1BP2 ^@ http://purl.uniprot.org/uniprot/G1NBK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/9103:ND4L ^@ http://purl.uniprot.org/uniprot/A9XBE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:MFN2 ^@ http://purl.uniprot.org/uniprot/G1N301 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9103:GET1 ^@ http://purl.uniprot.org/uniprot/G1NNZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:ADAMTS13 ^@ http://purl.uniprot.org/uniprot/G1N475 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:CRB2 ^@ http://purl.uniprot.org/uniprot/A0A803YNA6|||http://purl.uniprot.org/uniprot/G1N7Z5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:SHMT1 ^@ http://purl.uniprot.org/uniprot/G1N0B8 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9103:SERPINH1 ^@ http://purl.uniprot.org/uniprot/G3UT05 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9103:FECH ^@ http://purl.uniprot.org/uniprot/A0A803XUP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100548330 ^@ http://purl.uniprot.org/uniprot/A0A803YNF5 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9103:CALHM2 ^@ http://purl.uniprot.org/uniprot/G1NDJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9103:NDUFA12 ^@ http://purl.uniprot.org/uniprot/A0A803Y9S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:POMT1 ^@ http://purl.uniprot.org/uniprot/G1N2B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9103:THBS2 ^@ http://purl.uniprot.org/uniprot/G1NI19 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:MGST1 ^@ http://purl.uniprot.org/uniprot/G1NLF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9103:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/G1N8G8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/G1NQE6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:GLB1 ^@ http://purl.uniprot.org/uniprot/G1NGW0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9103:COQ8A ^@ http://purl.uniprot.org/uniprot/G1N2M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane|||Mitochondrion http://togogenome.org/gene/9103:KPNA7 ^@ http://purl.uniprot.org/uniprot/G1MY68 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/9103:SUCLG2 ^@ http://purl.uniprot.org/uniprot/G3UR69 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/9103:SST ^@ http://purl.uniprot.org/uniprot/G1N6K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9103:B4GALT4 ^@ http://purl.uniprot.org/uniprot/A0A803Y346 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9103:LOC100540152 ^@ http://purl.uniprot.org/uniprot/A0A803XTC5|||http://purl.uniprot.org/uniprot/G1MQV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SLC1A7 ^@ http://purl.uniprot.org/uniprot/G1NFH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9103:LOC100548691 ^@ http://purl.uniprot.org/uniprot/G1NMU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. http://togogenome.org/gene/9103:EXOSC9 ^@ http://purl.uniprot.org/uniprot/G1NDW4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:NR1H4 ^@ http://purl.uniprot.org/uniprot/G3UT50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/9103:SSRP1 ^@ http://purl.uniprot.org/uniprot/G1NBU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9103:RAD51D ^@ http://purl.uniprot.org/uniprot/G1MYJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/9103:KCNG1 ^@ http://purl.uniprot.org/uniprot/G1NAS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A803YJX3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9103:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A803XRD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9103:ATP5F1A ^@ http://purl.uniprot.org/uniprot/G1NC68 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9103:ATP5F1C ^@ http://purl.uniprot.org/uniprot/G1MZ35 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9103:MRPS15 ^@ http://purl.uniprot.org/uniprot/G1MWW2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9103:TPI1 ^@ http://purl.uniprot.org/uniprot/G1NMV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/9103:CKS2 ^@ http://purl.uniprot.org/uniprot/G1MT56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9103:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A803YHD9 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9103:NUP107 ^@ http://purl.uniprot.org/uniprot/G1NDI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9103:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A803XYW5|||http://purl.uniprot.org/uniprot/A0A803YEP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9103:ATE1 ^@ http://purl.uniprot.org/uniprot/A0A803XLY2|||http://purl.uniprot.org/uniprot/A0A803XPL6 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/9103:POLR2L ^@ http://purl.uniprot.org/uniprot/G1NGE6 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/9103:LOC104912152 ^@ http://purl.uniprot.org/uniprot/G1MUN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9103:LAMC3 ^@ http://purl.uniprot.org/uniprot/G1N1S6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9103:NUP205 ^@ http://purl.uniprot.org/uniprot/G1NGU0 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9103:TULP3 ^@ http://purl.uniprot.org/uniprot/G1NMC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9103:SNX7 ^@ http://purl.uniprot.org/uniprot/G1N5U1 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9103:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A803Y1T5|||http://purl.uniprot.org/uniprot/A0A803YCI0|||http://purl.uniprot.org/uniprot/G1N750 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:PREPL ^@ http://purl.uniprot.org/uniprot/G1NCW4 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9103:UBN1 ^@ http://purl.uniprot.org/uniprot/G1NBV9 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9103:LOC100550554 ^@ http://purl.uniprot.org/uniprot/A0A803YQ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9103:USP20 ^@ http://purl.uniprot.org/uniprot/G1N0U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||centrosome|||perinuclear region http://togogenome.org/gene/9103:PLIN1 ^@ http://purl.uniprot.org/uniprot/G1N8E6 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9103:SPR ^@ http://purl.uniprot.org/uniprot/G1NKT4 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9103:HEATR5A ^@ http://purl.uniprot.org/uniprot/A0A803XUH6|||http://purl.uniprot.org/uniprot/G1NIJ2 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9103:LOC100548634 ^@ http://purl.uniprot.org/uniprot/G1NPZ7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:ATP5F1B ^@ http://purl.uniprot.org/uniprot/H9H062 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9103:SLC6A12 ^@ http://purl.uniprot.org/uniprot/G1NL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9103:CTBP2 ^@ http://purl.uniprot.org/uniprot/G1NGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9103:CORO1C ^@ http://purl.uniprot.org/uniprot/G1N2E7 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9103:WASHC1 ^@ http://purl.uniprot.org/uniprot/A0A803XLS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9103:ITIH5 ^@ http://purl.uniprot.org/uniprot/G1MYQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9103:SLAIN2 ^@ http://purl.uniprot.org/uniprot/G1NHE4 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9103:CCR5 ^@ http://purl.uniprot.org/uniprot/G1NGB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:TMEM50B ^@ http://purl.uniprot.org/uniprot/G1NNX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9103:PALM ^@ http://purl.uniprot.org/uniprot/G1MWL4 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9103:CMKLR1 ^@ http://purl.uniprot.org/uniprot/G1NR61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SRM ^@ http://purl.uniprot.org/uniprot/A0A803XL48 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9103:SDC2 ^@ http://purl.uniprot.org/uniprot/Q5I5K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9103:KATNAL2 ^@ http://purl.uniprot.org/uniprot/A0A803Y023 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9103:PIGO ^@ http://purl.uniprot.org/uniprot/A0A803YD31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:DCSTAMP ^@ http://purl.uniprot.org/uniprot/G1NID4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100546123 ^@ http://purl.uniprot.org/uniprot/G1MTH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/9103:GABRA1 ^@ http://purl.uniprot.org/uniprot/G1MUV7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:RABGGTB ^@ http://purl.uniprot.org/uniprot/G1NHW3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9103:NME8 ^@ http://purl.uniprot.org/uniprot/A0A803YGM5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9103:VILL ^@ http://purl.uniprot.org/uniprot/G1MWE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||filopodium tip|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/9103:LOC100539381 ^@ http://purl.uniprot.org/uniprot/G1MT01 ^@ Similarity ^@ Belongs to the avidin/streptavidin family. http://togogenome.org/gene/9103:DDB2 ^@ http://purl.uniprot.org/uniprot/A0A803XV87|||http://purl.uniprot.org/uniprot/G1NE70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9103:HDLBP ^@ http://purl.uniprot.org/uniprot/G1MXC2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:LOC104914326 ^@ http://purl.uniprot.org/uniprot/A0A803YE52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TOB2 ^@ http://purl.uniprot.org/uniprot/G1NRJ4 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9103:PHKG1 ^@ http://purl.uniprot.org/uniprot/G1MZ21 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9103:SLC26A3 ^@ http://purl.uniprot.org/uniprot/G1NC25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Chloride/bicarbonate exchanger.|||Membrane http://togogenome.org/gene/9103:ALG11 ^@ http://purl.uniprot.org/uniprot/G1NQ78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9103:HNF4G ^@ http://purl.uniprot.org/uniprot/G1NGD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:TCEA3 ^@ http://purl.uniprot.org/uniprot/G1MS07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9103:RPL3 ^@ http://purl.uniprot.org/uniprot/G1NIE8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9103:PCNA ^@ http://purl.uniprot.org/uniprot/G1MPU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9103:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A803Y8P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9103:CCDC93 ^@ http://purl.uniprot.org/uniprot/G1NIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC93 family.|||Early endosome http://togogenome.org/gene/9103:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A803Y7J2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9103:CD28 ^@ http://purl.uniprot.org/uniprot/G1N9E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:AP3M2 ^@ http://purl.uniprot.org/uniprot/G1MVM0 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/9103:HSPB1 ^@ http://purl.uniprot.org/uniprot/G1MX59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/9103:CCNJL ^@ http://purl.uniprot.org/uniprot/G1MVB3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9103:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A803XZL3 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/9103:FAM8A1 ^@ http://purl.uniprot.org/uniprot/G1MVT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A803YLA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9103:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/G1NE90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9103:LOC100541467 ^@ http://purl.uniprot.org/uniprot/G1N1V2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9103:DDX6 ^@ http://purl.uniprot.org/uniprot/G1MYA1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9103:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/G1N0G0 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9103:NR4A3 ^@ http://purl.uniprot.org/uniprot/G1N700 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:STAT3 ^@ http://purl.uniprot.org/uniprot/G1MWW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:TAF7L ^@ http://purl.uniprot.org/uniprot/G1NAX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9103:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A803YEV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:PITX3 ^@ http://purl.uniprot.org/uniprot/G1N5L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9103:LOC100544032 ^@ http://purl.uniprot.org/uniprot/G1MWU5 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9103:LOC100550565 ^@ http://purl.uniprot.org/uniprot/G1MPT1 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/9103:ADD3 ^@ http://purl.uniprot.org/uniprot/G1NE42|||http://purl.uniprot.org/uniprot/G5E7P1 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9103:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A803XR94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Nucleus http://togogenome.org/gene/9103:RPL21 ^@ http://purl.uniprot.org/uniprot/G1NQD4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9103:BBS7 ^@ http://purl.uniprot.org/uniprot/G3UUI8 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9103:MCM5 ^@ http://purl.uniprot.org/uniprot/G1NJC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9103:ASIP ^@ http://purl.uniprot.org/uniprot/G1MTH0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:MRPL50 ^@ http://purl.uniprot.org/uniprot/G1NS09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9103:LOC100549991 ^@ http://purl.uniprot.org/uniprot/G1NRE1 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9103:LDHB ^@ http://purl.uniprot.org/uniprot/G1NLS0 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9103:EXOC3L4 ^@ http://purl.uniprot.org/uniprot/G1NL01 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9103:CCN4 ^@ http://purl.uniprot.org/uniprot/G1NJM6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:TOP1MT ^@ http://purl.uniprot.org/uniprot/G1MVV7|||http://purl.uniprot.org/uniprot/G1NK05 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9103:CLGN ^@ http://purl.uniprot.org/uniprot/G1MVE5 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9103:FAT1 ^@ http://purl.uniprot.org/uniprot/A0A803XKS9|||http://purl.uniprot.org/uniprot/A0A803Y7D5|||http://purl.uniprot.org/uniprot/G1NG27 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:SPDL1 ^@ http://purl.uniprot.org/uniprot/G1MTA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Spindly family.|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.|||kinetochore http://togogenome.org/gene/9103:TNNT3 ^@ http://purl.uniprot.org/uniprot/Q9DE11 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9103:NCAPD3 ^@ http://purl.uniprot.org/uniprot/G1MS44 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/9103:PDE6H ^@ http://purl.uniprot.org/uniprot/G1NGX5 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9103:DIPK2A ^@ http://purl.uniprot.org/uniprot/G1N474 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9103:NDUFS7 ^@ http://purl.uniprot.org/uniprot/G1MY84 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/9103:TMCC1 ^@ http://purl.uniprot.org/uniprot/G1ND60 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9103:LOC100546220 ^@ http://purl.uniprot.org/uniprot/G1N3F2 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9103:HADHA ^@ http://purl.uniprot.org/uniprot/G1NMS8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9103:RPL6 ^@ http://purl.uniprot.org/uniprot/G1N231 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9103:RASGRP3 ^@ http://purl.uniprot.org/uniprot/G1NEU8 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9103:GAR1 ^@ http://purl.uniprot.org/uniprot/G1NEY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9103:SUSD1 ^@ http://purl.uniprot.org/uniprot/A0A803YJ29|||http://purl.uniprot.org/uniprot/G1N8M3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:IL18RAP ^@ http://purl.uniprot.org/uniprot/G1NPN2 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9103:RELL1 ^@ http://purl.uniprot.org/uniprot/G1NIE9 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9103:LOC100549312 ^@ http://purl.uniprot.org/uniprot/G1NDC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9103:SMAD1 ^@ http://purl.uniprot.org/uniprot/G1MXC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:SLC24A5 ^@ http://purl.uniprot.org/uniprot/G1N503 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9103:GOLT1B ^@ http://purl.uniprot.org/uniprot/G1NLK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9103:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A803YGD9 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9103:ECI1 ^@ http://purl.uniprot.org/uniprot/G1NA60 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9103:LOC100548173 ^@ http://purl.uniprot.org/uniprot/G1NNC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:CLDN3 ^@ http://purl.uniprot.org/uniprot/G1N4Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:PHF5A ^@ http://purl.uniprot.org/uniprot/G1NHU8 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9103:NRDC ^@ http://purl.uniprot.org/uniprot/G1NF14 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9103:THG1L ^@ http://purl.uniprot.org/uniprot/G1N0C5 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9103:HGD ^@ http://purl.uniprot.org/uniprot/G1NN95 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9103:LOC100539820 ^@ http://purl.uniprot.org/uniprot/G1NFZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:MARK1 ^@ http://purl.uniprot.org/uniprot/A0A803XPM4|||http://purl.uniprot.org/uniprot/G1NA51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9103:MSH5 ^@ http://purl.uniprot.org/uniprot/G1NRT2 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9103:AP5M1 ^@ http://purl.uniprot.org/uniprot/G1NLK4 ^@ Subcellular Location Annotation|||Subunit ^@ Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9103:LOC100549086 ^@ http://purl.uniprot.org/uniprot/G3UTL5 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).|||cytosol http://togogenome.org/gene/9103:LOC100548843 ^@ http://purl.uniprot.org/uniprot/G1NIJ9 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9103:LOC100549590 ^@ http://purl.uniprot.org/uniprot/G1MYP6 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9103:LOC100547828 ^@ http://purl.uniprot.org/uniprot/A0A803XMA3 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9103:HSPD1 ^@ http://purl.uniprot.org/uniprot/G1N5G4 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9103:FZD9 ^@ http://purl.uniprot.org/uniprot/G1MQY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/G1NP47|||http://purl.uniprot.org/uniprot/G3US21 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9103:LOC100541308 ^@ http://purl.uniprot.org/uniprot/A0A803XPL7|||http://purl.uniprot.org/uniprot/A0A803Y8L6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:ACTA2 ^@ http://purl.uniprot.org/uniprot/G1N8B9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:TM9SF3 ^@ http://purl.uniprot.org/uniprot/A0A803XXB8|||http://purl.uniprot.org/uniprot/G3UP22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9103:GUCY1B1 ^@ http://purl.uniprot.org/uniprot/A0A803Y2Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9103:PCK1 ^@ http://purl.uniprot.org/uniprot/G1NA26 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9103:INTS13 ^@ http://purl.uniprot.org/uniprot/G1NLT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:ACOX3 ^@ http://purl.uniprot.org/uniprot/G1NJP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9103:LOC104911959 ^@ http://purl.uniprot.org/uniprot/A0A803Y0S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9103:ACOX2 ^@ http://purl.uniprot.org/uniprot/G1N9E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9103:LOC100546481 ^@ http://purl.uniprot.org/uniprot/G1NMI9 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9103:CTDP1 ^@ http://purl.uniprot.org/uniprot/A0A803XR93 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/9103:PCNX4 ^@ http://purl.uniprot.org/uniprot/G1NLG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9103:PCBD1 ^@ http://purl.uniprot.org/uniprot/G1N0R5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9103:SLCO3A1 ^@ http://purl.uniprot.org/uniprot/G1N9S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:RIC8A ^@ http://purl.uniprot.org/uniprot/G1MU59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9103:TMEM231 ^@ http://purl.uniprot.org/uniprot/G1NA37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9103:NATD1 ^@ http://purl.uniprot.org/uniprot/G1MYJ9 ^@ Similarity ^@ Belongs to the NATD1 family. http://togogenome.org/gene/9103:LOC100544984 ^@ http://purl.uniprot.org/uniprot/G1MU85 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9103:ADGRG1 ^@ http://purl.uniprot.org/uniprot/A0A803YCL8 ^@ Subcellular Location Annotation ^@ Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9103:VWA2 ^@ http://purl.uniprot.org/uniprot/G1NF03 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:GLYCTK ^@ http://purl.uniprot.org/uniprot/G1MWH3 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9103:TAF5L ^@ http://purl.uniprot.org/uniprot/G1NHL1 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9103:SLC26A5 ^@ http://purl.uniprot.org/uniprot/A0A803YKU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9103:KCNE2 ^@ http://purl.uniprot.org/uniprot/G1NS86 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9103:ZNF711 ^@ http://purl.uniprot.org/uniprot/G1MZJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:USP2 ^@ http://purl.uniprot.org/uniprot/G1MU74 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9103:LOC104913852 ^@ http://purl.uniprot.org/uniprot/A0A803Y3R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9103:LOC100547693 ^@ http://purl.uniprot.org/uniprot/G1N8W5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:HLCS ^@ http://purl.uniprot.org/uniprot/G1NNY4 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9103:LOC100544563 ^@ http://purl.uniprot.org/uniprot/G1N151 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A803YS38 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9103:CACNG2 ^@ http://purl.uniprot.org/uniprot/G1NJ55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9103:TRAF4 ^@ http://purl.uniprot.org/uniprot/G1NJG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9103:NAGA ^@ http://purl.uniprot.org/uniprot/G1NHI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9103:DOT1L ^@ http://purl.uniprot.org/uniprot/G1MT95 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||Histone methyltransferase. Methylates 'Lys-79' of histone H3.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/9103:NEFM ^@ http://purl.uniprot.org/uniprot/G1MQU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon|||cytoskeleton http://togogenome.org/gene/9103:LOC100547769 ^@ http://purl.uniprot.org/uniprot/G1MXV7 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9103:LOC100544185 ^@ http://purl.uniprot.org/uniprot/G1MUM1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9103:TBX22 ^@ http://purl.uniprot.org/uniprot/G1MSC0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:LOC100546358 ^@ http://purl.uniprot.org/uniprot/A0A803YGR1|||http://purl.uniprot.org/uniprot/G1N1C6 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9103:TYW3 ^@ http://purl.uniprot.org/uniprot/G1NHT7 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9103:KRR1 ^@ http://purl.uniprot.org/uniprot/G1NEE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9103:STS ^@ http://purl.uniprot.org/uniprot/G1NP33 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9103:ASPN ^@ http://purl.uniprot.org/uniprot/G1MZ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9103:ATP6 ^@ http://purl.uniprot.org/uniprot/A9XBE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:MTRF1 ^@ http://purl.uniprot.org/uniprot/G1NQ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9103:LOC100551379 ^@ http://purl.uniprot.org/uniprot/G1MY81 ^@ Similarity ^@ Belongs to the lst-2 family. http://togogenome.org/gene/9103:SLC7A9 ^@ http://purl.uniprot.org/uniprot/G1N206 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:NIPAL3 ^@ http://purl.uniprot.org/uniprot/G1N2N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9103:ELF2 ^@ http://purl.uniprot.org/uniprot/G1MV21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:SNAP23 ^@ http://purl.uniprot.org/uniprot/G1NG88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/9103:P2RY4 ^@ http://purl.uniprot.org/uniprot/G1NRN1|||http://purl.uniprot.org/uniprot/O57466 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MRPL16 ^@ http://purl.uniprot.org/uniprot/G1MWA3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9103:SCAP ^@ http://purl.uniprot.org/uniprot/A0A803YMH6|||http://purl.uniprot.org/uniprot/G1MS81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9103:GRM3 ^@ http://purl.uniprot.org/uniprot/G1N0U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9103:CENPN ^@ http://purl.uniprot.org/uniprot/A0A803YFN2|||http://purl.uniprot.org/uniprot/G1N4J6 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9103:LOC100550526 ^@ http://purl.uniprot.org/uniprot/G1NLW9 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9103:NDUFA10 ^@ http://purl.uniprot.org/uniprot/A0A803XS04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/9103:SLC6A9 ^@ http://purl.uniprot.org/uniprot/G1NCD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LPAR4 ^@ http://purl.uniprot.org/uniprot/G1NRN7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:CPNE1 ^@ http://purl.uniprot.org/uniprot/G1MSB0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9103:VPS37C ^@ http://purl.uniprot.org/uniprot/A0A803XM91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9103:HPSE ^@ http://purl.uniprot.org/uniprot/G1N7R6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9103:TMED6 ^@ http://purl.uniprot.org/uniprot/G1N8V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:PPEF1 ^@ http://purl.uniprot.org/uniprot/G1NPA0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9103:RIN3 ^@ http://purl.uniprot.org/uniprot/G1NKC4 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9103:GRAMD1B ^@ http://purl.uniprot.org/uniprot/A0A803YNK6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:RPL9 ^@ http://purl.uniprot.org/uniprot/G1NI74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/9103:GPR17 ^@ http://purl.uniprot.org/uniprot/G1NRE3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:N6AMT1 ^@ http://purl.uniprot.org/uniprot/G1NNU4 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9103:TPRG1L ^@ http://purl.uniprot.org/uniprot/G1MSG5 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9103:LOC100543786 ^@ http://purl.uniprot.org/uniprot/G1NAG4 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9103:HAPLN3 ^@ http://purl.uniprot.org/uniprot/G1N954 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:TEKT4 ^@ http://purl.uniprot.org/uniprot/G1N166 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/9103:AP1M1 ^@ http://purl.uniprot.org/uniprot/G1N243 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9103:SH2B2 ^@ http://purl.uniprot.org/uniprot/G1MWL7 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9103:SNRPC ^@ http://purl.uniprot.org/uniprot/G1N2Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9103:GDI2 ^@ http://purl.uniprot.org/uniprot/G1MWF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9103:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/G1MTT6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9103:EPHX1 ^@ http://purl.uniprot.org/uniprot/G1N7M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Microsome membrane http://togogenome.org/gene/9103:SURF4 ^@ http://purl.uniprot.org/uniprot/G3UQ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/9103:TCEA2 ^@ http://purl.uniprot.org/uniprot/G1N4F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9103:PHETA2 ^@ http://purl.uniprot.org/uniprot/G1NRJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sesquipedalian family.|||Early endosome|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9103:LOC100543126 ^@ http://purl.uniprot.org/uniprot/H9H1T2 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9103:LOC100545239 ^@ http://purl.uniprot.org/uniprot/G1N291 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9103:RPS15 ^@ http://purl.uniprot.org/uniprot/G1MYH5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/9103:SMIM5 ^@ http://purl.uniprot.org/uniprot/G1N0A7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GCNT4 ^@ http://purl.uniprot.org/uniprot/G1N079 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A803XTV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC104914240 ^@ http://purl.uniprot.org/uniprot/G1MUZ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:AQP1 ^@ http://purl.uniprot.org/uniprot/G1MSG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9103:PFN4 ^@ http://purl.uniprot.org/uniprot/G1NMP9 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9103:C3H5orf22 ^@ http://purl.uniprot.org/uniprot/G1N0J7 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9103:TCEA1 ^@ http://purl.uniprot.org/uniprot/G1NEK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.|||Nucleus http://togogenome.org/gene/9103:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A803YSG8|||http://purl.uniprot.org/uniprot/G1NKT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9103:DHRS7C ^@ http://purl.uniprot.org/uniprot/H9H2L1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:MRPS9 ^@ http://purl.uniprot.org/uniprot/A0A803Y0F2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9103:ESCO1 ^@ http://purl.uniprot.org/uniprot/G1NC62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SNAP25 ^@ http://purl.uniprot.org/uniprot/G1N3J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/9103:GPR161 ^@ http://purl.uniprot.org/uniprot/G1NNG3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:SFRP2 ^@ http://purl.uniprot.org/uniprot/G1MRC5 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CCN5 ^@ http://purl.uniprot.org/uniprot/G1MXL4 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9103:BDNF ^@ http://purl.uniprot.org/uniprot/G1NQZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.|||Secreted http://togogenome.org/gene/9103:KCNS3 ^@ http://purl.uniprot.org/uniprot/G1NRE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SLC25A30 ^@ http://purl.uniprot.org/uniprot/G1NQ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:FAM110C ^@ http://purl.uniprot.org/uniprot/A0A803XRW2 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9103:MED22 ^@ http://purl.uniprot.org/uniprot/G1N3R2 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9103:LOC100542800 ^@ http://purl.uniprot.org/uniprot/G1NS52 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9103:LRRC42 ^@ http://purl.uniprot.org/uniprot/G1NFP5 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9103:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A803XSY4|||http://purl.uniprot.org/uniprot/A0A803YJD3 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9103:HNF1A ^@ http://purl.uniprot.org/uniprot/G5E7Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9103:ALG6 ^@ http://purl.uniprot.org/uniprot/G1NGT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:NSUN4 ^@ http://purl.uniprot.org/uniprot/G1NDY0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9103:LOC104909481 ^@ http://purl.uniprot.org/uniprot/G1MRW3 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/9103:DCAF13 ^@ http://purl.uniprot.org/uniprot/G1NIB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/9103:C3H8orf37 ^@ http://purl.uniprot.org/uniprot/G1NHP4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9103:SCD5 ^@ http://purl.uniprot.org/uniprot/G1N7I0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9103:NEU2 ^@ http://purl.uniprot.org/uniprot/G1MSG2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9103:LOC104912421 ^@ http://purl.uniprot.org/uniprot/A0A803XNQ0 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9103:KCNJ2 ^@ http://purl.uniprot.org/uniprot/G1N4D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9103:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/G1MX18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:LOC100545477 ^@ http://purl.uniprot.org/uniprot/G1NFH8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:MMACHC ^@ http://purl.uniprot.org/uniprot/G1NDA0 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9103:CCT5 ^@ http://purl.uniprot.org/uniprot/A0A803YE35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9103:TOP3A ^@ http://purl.uniprot.org/uniprot/G1N063 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9103:LOC100545232 ^@ http://purl.uniprot.org/uniprot/G1N5S4 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9103:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A803XSV2|||http://purl.uniprot.org/uniprot/A0A803YKF5 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9103:RIOX2 ^@ http://purl.uniprot.org/uniprot/G1NNN3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.|||nucleolus http://togogenome.org/gene/9103:STON2 ^@ http://purl.uniprot.org/uniprot/G3UP36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/9103:HOXD11 ^@ http://purl.uniprot.org/uniprot/G1NBH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9103:DAG1 ^@ http://purl.uniprot.org/uniprot/G1MW21 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9103:MINDY4 ^@ http://purl.uniprot.org/uniprot/A0A803XL46 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9103:WDR24 ^@ http://purl.uniprot.org/uniprot/G1NBQ2 ^@ Similarity ^@ Belongs to the WD repeat WDR24 family. http://togogenome.org/gene/9103:LACC1 ^@ http://purl.uniprot.org/uniprot/A0A803YFA8 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/9103:TMEM182 ^@ http://purl.uniprot.org/uniprot/G1NPN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:C23H1orf174 ^@ http://purl.uniprot.org/uniprot/G1MS35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0688 family.|||Nucleus http://togogenome.org/gene/9103:RPL19 ^@ http://purl.uniprot.org/uniprot/G1N109 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9103:TRMT5 ^@ http://purl.uniprot.org/uniprot/G1NLE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/9103:LOC100545577 ^@ http://purl.uniprot.org/uniprot/G1NGK0 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9103:DPH2 ^@ http://purl.uniprot.org/uniprot/G1NC63 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9103:ETS1 ^@ http://purl.uniprot.org/uniprot/G1MQK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CD247 ^@ http://purl.uniprot.org/uniprot/G1NNP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GTF2H1 ^@ http://purl.uniprot.org/uniprot/G1N626 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9103:B3GNT7 ^@ http://purl.uniprot.org/uniprot/G1N7V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:SSTR3 ^@ http://purl.uniprot.org/uniprot/G1NIZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MCM2 ^@ http://purl.uniprot.org/uniprot/G3UP98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/9103:CPEB4 ^@ http://purl.uniprot.org/uniprot/G1MX60 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9103:STON1 ^@ http://purl.uniprot.org/uniprot/G1N1Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm|||May be involved in the endocytic machinery. http://togogenome.org/gene/9103:EGFR ^@ http://purl.uniprot.org/uniprot/G3UQM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9103:LOC104912373 ^@ http://purl.uniprot.org/uniprot/G1NLN6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:SLC7A6 ^@ http://purl.uniprot.org/uniprot/G1MXI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TDP2 ^@ http://purl.uniprot.org/uniprot/G1N7I1 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9103:RPLP2 ^@ http://purl.uniprot.org/uniprot/G1NA41 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9103:SLC8A3 ^@ http://purl.uniprot.org/uniprot/G1NGX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MAP3K8 ^@ http://purl.uniprot.org/uniprot/G1N440 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9103:SLC25A46 ^@ http://purl.uniprot.org/uniprot/G1N4S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9103:RPS24 ^@ http://purl.uniprot.org/uniprot/G1N224 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9103:ANO9 ^@ http://purl.uniprot.org/uniprot/G1MUT9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:NDC80 ^@ http://purl.uniprot.org/uniprot/G1MYF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9103:SIGIRR ^@ http://purl.uniprot.org/uniprot/G1MUL1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9103:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/G1NH79 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9103:LOC100548817 ^@ http://purl.uniprot.org/uniprot/G1NR58 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC109365718 ^@ http://purl.uniprot.org/uniprot/A0A803YKV9 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/9103:SF3B6 ^@ http://purl.uniprot.org/uniprot/G1NMP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SHOC2 ^@ http://purl.uniprot.org/uniprot/G1NEF4 ^@ Function|||Similarity ^@ Belongs to the SHOC2 family.|||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. http://togogenome.org/gene/9103:CTSH ^@ http://purl.uniprot.org/uniprot/G1NDQ5 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9103:FAM118B ^@ http://purl.uniprot.org/uniprot/G1MPZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM118 family.|||Cajal body|||May play a role in Cajal bodies formation. http://togogenome.org/gene/9103:PPM1B ^@ http://purl.uniprot.org/uniprot/G3UR13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9103:FAM83G ^@ http://purl.uniprot.org/uniprot/G1N0P6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9103:NAA60 ^@ http://purl.uniprot.org/uniprot/G1NAA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9103:LOC100548608 ^@ http://purl.uniprot.org/uniprot/G1NRD8 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9103:GLI3 ^@ http://purl.uniprot.org/uniprot/A0A803YD02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:SDR42E1 ^@ http://purl.uniprot.org/uniprot/G1N520 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9103:LOC100541434 ^@ http://purl.uniprot.org/uniprot/G1NRI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:SIAH1 ^@ http://purl.uniprot.org/uniprot/G1NRC3 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9103:LOC100542495 ^@ http://purl.uniprot.org/uniprot/G1MWB0 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9103:CLDN8 ^@ http://purl.uniprot.org/uniprot/G1NS63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:PPA1 ^@ http://purl.uniprot.org/uniprot/G1N1A9 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9103:MAP2K6 ^@ http://purl.uniprot.org/uniprot/G1N4E6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:LOC104916371 ^@ http://purl.uniprot.org/uniprot/A0A803XMX3 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9103:LOC100548327 ^@ http://purl.uniprot.org/uniprot/G1NQU6 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9103:LOC100549995 ^@ http://purl.uniprot.org/uniprot/G1NR48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:UNG ^@ http://purl.uniprot.org/uniprot/G1N2T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9103:BPNT1 ^@ http://purl.uniprot.org/uniprot/G1NAF6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9103:PIWIL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y0D8|||http://purl.uniprot.org/uniprot/G1MU43 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9103:ARPC1A ^@ http://purl.uniprot.org/uniprot/G1MYA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9103:CHRNA6 ^@ http://purl.uniprot.org/uniprot/A0A803XN71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:WTAP ^@ http://purl.uniprot.org/uniprot/G1NIQ5 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9103:SAR1A ^@ http://purl.uniprot.org/uniprot/G1N1C1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9103:CLSTN3 ^@ http://purl.uniprot.org/uniprot/G1NMY8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:OCSTAMP ^@ http://purl.uniprot.org/uniprot/A0A803YEQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:HMGB2 ^@ http://purl.uniprot.org/uniprot/G1N4V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9103:ORMDL1 ^@ http://purl.uniprot.org/uniprot/G1N382 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9103:TRPC1 ^@ http://purl.uniprot.org/uniprot/G1N410 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/9103:TM4SF4 ^@ http://purl.uniprot.org/uniprot/G1NES9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9103:TMEM151B ^@ http://purl.uniprot.org/uniprot/G1NRQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/9103:LOC100547473 ^@ http://purl.uniprot.org/uniprot/G1NK97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:ANTXRL ^@ http://purl.uniprot.org/uniprot/G1N7B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9103:LOC104914521 ^@ http://purl.uniprot.org/uniprot/A0A803XTW7 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9103:B3GALT1 ^@ http://purl.uniprot.org/uniprot/G1NRV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:LOC100549255 ^@ http://purl.uniprot.org/uniprot/A0A803XLJ4|||http://purl.uniprot.org/uniprot/A0A803XR41|||http://purl.uniprot.org/uniprot/A0A803Y1R0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:EOGT ^@ http://purl.uniprot.org/uniprot/G1NAT4 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/9103:LOC100543851 ^@ http://purl.uniprot.org/uniprot/G3UV18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9103:NKAIN4 ^@ http://purl.uniprot.org/uniprot/A0A803YGL9|||http://purl.uniprot.org/uniprot/G1N397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:KLHL22 ^@ http://purl.uniprot.org/uniprot/G1N6V2 ^@ Subcellular Location Annotation ^@ Lysosome|||Nucleus|||centrosome|||cytosol|||spindle http://togogenome.org/gene/9103:GHRH ^@ http://purl.uniprot.org/uniprot/G1MTN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9103:LOC109367286 ^@ http://purl.uniprot.org/uniprot/G1NDH6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:LOC100549955 ^@ http://purl.uniprot.org/uniprot/G1MV65 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9103:LOC723983 ^@ http://purl.uniprot.org/uniprot/Q9IAT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:SLC5A12 ^@ http://purl.uniprot.org/uniprot/G1MSN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9103:LIMD1 ^@ http://purl.uniprot.org/uniprot/G1NGF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zyxin/ajuba family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:UBLCP1 ^@ http://purl.uniprot.org/uniprot/G1N014 ^@ Function|||Subcellular Location Annotation ^@ Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|||Nucleus http://togogenome.org/gene/9103:LOC100541513 ^@ http://purl.uniprot.org/uniprot/G1N736 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9103:HEXA ^@ http://purl.uniprot.org/uniprot/G1MRV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9103:LOC100545134 ^@ http://purl.uniprot.org/uniprot/G1N1L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Nucleus http://togogenome.org/gene/9103:ETV6 ^@ http://purl.uniprot.org/uniprot/A0A803YGK7|||http://purl.uniprot.org/uniprot/G1NM59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:SGF29 ^@ http://purl.uniprot.org/uniprot/G1NHX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:BLMH ^@ http://purl.uniprot.org/uniprot/G1N312 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9103:IWS1 ^@ http://purl.uniprot.org/uniprot/G1MRV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:EPHA5 ^@ http://purl.uniprot.org/uniprot/G1NNL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:OSBPL1A ^@ http://purl.uniprot.org/uniprot/G1ND00 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9103:LOC100548974 ^@ http://purl.uniprot.org/uniprot/A0A803Y911 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9103:SLC17A6 ^@ http://purl.uniprot.org/uniprot/G1MT63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CCR7 ^@ http://purl.uniprot.org/uniprot/G1MV68 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:GUF1 ^@ http://purl.uniprot.org/uniprot/A0A803YAQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/9103:TRDMT1 ^@ http://purl.uniprot.org/uniprot/A0A803YAM3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9103:GK ^@ http://purl.uniprot.org/uniprot/G3UUV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9103:CCDC107 ^@ http://purl.uniprot.org/uniprot/G1NEC0 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9103:LOC100539604 ^@ http://purl.uniprot.org/uniprot/G1MV57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:IL26 ^@ http://purl.uniprot.org/uniprot/G1NDA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9103:MFSD1 ^@ http://purl.uniprot.org/uniprot/G1NDU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:HTR6 ^@ http://purl.uniprot.org/uniprot/G1N1I6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:UTP14A ^@ http://purl.uniprot.org/uniprot/G1MSX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9103:ACSL6 ^@ http://purl.uniprot.org/uniprot/G1N9D1|||http://purl.uniprot.org/uniprot/G3UQP1 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/9103:TGFB2 ^@ http://purl.uniprot.org/uniprot/G1NAV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9103:CACNG5 ^@ http://purl.uniprot.org/uniprot/G1N656 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/9103:CRY2 ^@ http://purl.uniprot.org/uniprot/G1NF23 ^@ Similarity ^@ Belongs to the DNA photolyase class-1 family. http://togogenome.org/gene/9103:OIP5 ^@ http://purl.uniprot.org/uniprot/G1NFA7 ^@ Function|||Subcellular Location Annotation ^@ Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9103:MRPS33 ^@ http://purl.uniprot.org/uniprot/G1NKL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9103:ZBED1 ^@ http://purl.uniprot.org/uniprot/G1NR66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:XRCC4 ^@ http://purl.uniprot.org/uniprot/A0A803Y7H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9103:RMND1 ^@ http://purl.uniprot.org/uniprot/G1NJ72 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/9103:LOC100550530 ^@ http://purl.uniprot.org/uniprot/G1NQP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A803XMB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9103:PLXNB2 ^@ http://purl.uniprot.org/uniprot/G3US56 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:MON1A ^@ http://purl.uniprot.org/uniprot/G1MUS3 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9103:GPX7 ^@ http://purl.uniprot.org/uniprot/G1NFC2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9103:COX3 ^@ http://purl.uniprot.org/uniprot/F1JUM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/9103:CHRNB4 ^@ http://purl.uniprot.org/uniprot/G1MWW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:NDEL1 ^@ http://purl.uniprot.org/uniprot/A0A803XUC7|||http://purl.uniprot.org/uniprot/G1MU68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/9103:AVPR1B ^@ http://purl.uniprot.org/uniprot/G1MWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/G1MW09 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9103:LAPTM5 ^@ http://purl.uniprot.org/uniprot/G1MPW9 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9103:CXCR4 ^@ http://purl.uniprot.org/uniprot/G1NRY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/9103:GSTA3 ^@ http://purl.uniprot.org/uniprot/D4N2R6 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9103:PPP1R21 ^@ http://purl.uniprot.org/uniprot/G1N0H7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9103:LOC109363691 ^@ http://purl.uniprot.org/uniprot/G1MUD5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9103:ING4 ^@ http://purl.uniprot.org/uniprot/G1NMT4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9103:LOC100549427 ^@ http://purl.uniprot.org/uniprot/G1N492 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:TCP11L1 ^@ http://purl.uniprot.org/uniprot/G1MRE9 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9103:BLM ^@ http://purl.uniprot.org/uniprot/H9H1R8 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9103:DUSP10 ^@ http://purl.uniprot.org/uniprot/G1N9X4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9103:LOC104914617 ^@ http://purl.uniprot.org/uniprot/A0A803YHG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A803XWA9|||http://purl.uniprot.org/uniprot/G1MYJ4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:MAEA ^@ http://purl.uniprot.org/uniprot/G1NK88 ^@ Subcellular Location Annotation ^@ Nucleus matrix http://togogenome.org/gene/9103:SLC35F4 ^@ http://purl.uniprot.org/uniprot/A0A803YEC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9103:LOC100551469 ^@ http://purl.uniprot.org/uniprot/G1MZ37 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9103:LOC109367190 ^@ http://purl.uniprot.org/uniprot/A0A803XXM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9103:TUBGCP6 ^@ http://purl.uniprot.org/uniprot/A0A803Y1I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||centrosome http://togogenome.org/gene/9103:ADCK1 ^@ http://purl.uniprot.org/uniprot/G1NJT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/9103:OSBPL6 ^@ http://purl.uniprot.org/uniprot/G1NB13 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9103:PKM ^@ http://purl.uniprot.org/uniprot/A0A803YCD2|||http://purl.uniprot.org/uniprot/G1MSA4 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9103:STMN1 ^@ http://purl.uniprot.org/uniprot/G1MV02 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9103:FAM3D ^@ http://purl.uniprot.org/uniprot/G1N9H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9103:LOC100542633 ^@ http://purl.uniprot.org/uniprot/G1NFP4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9103:VPS51 ^@ http://purl.uniprot.org/uniprot/G1MUP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.|||Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9103:KPNA2 ^@ http://purl.uniprot.org/uniprot/G1N6L6 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/9103:NSDHL ^@ http://purl.uniprot.org/uniprot/G1N1E3 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9103:LOC104913817 ^@ http://purl.uniprot.org/uniprot/A0A803XUT5 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9103:UTP3 ^@ http://purl.uniprot.org/uniprot/G1NC92 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/9103:LOC100538756 ^@ http://purl.uniprot.org/uniprot/G1MTR8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:SPRY1 ^@ http://purl.uniprot.org/uniprot/G1NRJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sprouty family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9103:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/G1NE61 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9103:TRNT1 ^@ http://purl.uniprot.org/uniprot/G1NC81 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9103:ERRFI1 ^@ http://purl.uniprot.org/uniprot/G1MQD7 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9103:PSPH ^@ http://purl.uniprot.org/uniprot/G1MYR6 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9103:CYP1A5 ^@ http://purl.uniprot.org/uniprot/Q56D25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9103:LIPT1 ^@ http://purl.uniprot.org/uniprot/G1NR74 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9103:LOC100539643 ^@ http://purl.uniprot.org/uniprot/G1NMT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9103:GPN3 ^@ http://purl.uniprot.org/uniprot/G1MXD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9103:LOC100541213 ^@ http://purl.uniprot.org/uniprot/G1MSP7 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9103:RNF13 ^@ http://purl.uniprot.org/uniprot/G1NER0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:FZD6 ^@ http://purl.uniprot.org/uniprot/G1NIC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:RNASEH1 ^@ http://purl.uniprot.org/uniprot/G1NMH5 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9103:RPL31 ^@ http://purl.uniprot.org/uniprot/G1NPL8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9103:PHC3 ^@ http://purl.uniprot.org/uniprot/G1NCV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLC29A1 ^@ http://purl.uniprot.org/uniprot/G1NEB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9103:B3GNT5 ^@ http://purl.uniprot.org/uniprot/G1NS21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:TRIM2 ^@ http://purl.uniprot.org/uniprot/G1MR29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9103:DEGS2 ^@ http://purl.uniprot.org/uniprot/G1NKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:AIDA ^@ http://purl.uniprot.org/uniprot/G1N9R3 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9103:AKR1A1 ^@ http://purl.uniprot.org/uniprot/G1NDE3 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9103:AP4B1 ^@ http://purl.uniprot.org/uniprot/G1N1P4 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9103:TSPAN12 ^@ http://purl.uniprot.org/uniprot/G1N996 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9103:POLR1C ^@ http://purl.uniprot.org/uniprot/G1NEV0 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9103:LOC100539376 ^@ http://purl.uniprot.org/uniprot/A0A803XK94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:DIPK2B ^@ http://purl.uniprot.org/uniprot/G1NP32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9103:LOC104914064 ^@ http://purl.uniprot.org/uniprot/A0A803XUZ5 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9103:LOC100544372 ^@ http://purl.uniprot.org/uniprot/H9H0S9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A803YG61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9103:TMCO3 ^@ http://purl.uniprot.org/uniprot/G1NPR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/A0A803XW10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9103:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A803YSC5 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9103:TPPP3 ^@ http://purl.uniprot.org/uniprot/H9H2H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPPP family.|||cytoskeleton http://togogenome.org/gene/9103:ATIC ^@ http://purl.uniprot.org/uniprot/G1MWQ1 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/9103:CSK ^@ http://purl.uniprot.org/uniprot/G1MU24|||http://purl.uniprot.org/uniprot/G3UP76 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9103:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A803Y0W2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9103:ORMDL3 ^@ http://purl.uniprot.org/uniprot/H9H0G9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9103:PDGFB ^@ http://purl.uniprot.org/uniprot/G1NL92 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9103:TBL3 ^@ http://purl.uniprot.org/uniprot/G5E7H5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9103:LGI1 ^@ http://purl.uniprot.org/uniprot/G1N9F8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:MOSPD1 ^@ http://purl.uniprot.org/uniprot/G1MWD2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:AMER3 ^@ http://purl.uniprot.org/uniprot/G1MQP4 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9103:CRAT ^@ http://purl.uniprot.org/uniprot/G1N094 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9103:LOC100540856 ^@ http://purl.uniprot.org/uniprot/G1N876 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline phosphatase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100545053 ^@ http://purl.uniprot.org/uniprot/A0A803XN99 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:MYOZ2 ^@ http://purl.uniprot.org/uniprot/G1NE80 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9103:LOC100540871 ^@ http://purl.uniprot.org/uniprot/G1MVJ4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:ETV1 ^@ http://purl.uniprot.org/uniprot/A0A803Y169|||http://purl.uniprot.org/uniprot/G1NCB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:CTU2 ^@ http://purl.uniprot.org/uniprot/G1N706 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTU2/NCS2 family.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9103:HMGB1 ^@ http://purl.uniprot.org/uniprot/G1NQB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome|||Secreted http://togogenome.org/gene/9103:LGR6 ^@ http://purl.uniprot.org/uniprot/G1MR85 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:FOXN4 ^@ http://purl.uniprot.org/uniprot/G1N344 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:MALSU1 ^@ http://purl.uniprot.org/uniprot/G1NDG8 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9103:LNPK ^@ http://purl.uniprot.org/uniprot/G1NBK3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9103:ENSA ^@ http://purl.uniprot.org/uniprot/G1MPY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9103:PLK3 ^@ http://purl.uniprot.org/uniprot/A0A803XXF0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9103:PODXL ^@ http://purl.uniprot.org/uniprot/A0A803XTN2|||http://purl.uniprot.org/uniprot/G1MXN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the podocalyxin family.|||Cell membrane|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/9103:CLUL1 ^@ http://purl.uniprot.org/uniprot/G1NBT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Secreted http://togogenome.org/gene/9103:TMEM184B ^@ http://purl.uniprot.org/uniprot/G1NIT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:MDK ^@ http://purl.uniprot.org/uniprot/G1NEU4 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9103:CRYAB ^@ http://purl.uniprot.org/uniprot/G1MZP6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9103:LOC100548577 ^@ http://purl.uniprot.org/uniprot/A0A803YL44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the noggin family.|||Secreted http://togogenome.org/gene/9103:LOC100542589 ^@ http://purl.uniprot.org/uniprot/G1N762 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9103:XIAP ^@ http://purl.uniprot.org/uniprot/A0A803YET2|||http://purl.uniprot.org/uniprot/A0A803YNK5|||http://purl.uniprot.org/uniprot/G1N606 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9103:TWSG1 ^@ http://purl.uniprot.org/uniprot/G1NA88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9103:GPRIN3 ^@ http://purl.uniprot.org/uniprot/G1NSA0 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9103:LITAF ^@ http://purl.uniprot.org/uniprot/G1MR95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:LOC100542551 ^@ http://purl.uniprot.org/uniprot/A0A803YLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9103:LOC100550137 ^@ http://purl.uniprot.org/uniprot/G1NI13 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9103:LOC100541395 ^@ http://purl.uniprot.org/uniprot/G1NQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:PARP9 ^@ http://purl.uniprot.org/uniprot/G1NI39 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9103:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/G1NEM3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:RPL8 ^@ http://purl.uniprot.org/uniprot/G1NP44 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9103:CEPT1 ^@ http://purl.uniprot.org/uniprot/G1N0Z0 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9103:AGMAT ^@ http://purl.uniprot.org/uniprot/G1N1M7 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/9103:NIPSNAP2 ^@ http://purl.uniprot.org/uniprot/G3US30 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9103:CHST4 ^@ http://purl.uniprot.org/uniprot/G1NRE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9103:RALA ^@ http://purl.uniprot.org/uniprot/G1NI18 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/9103:CD44 ^@ http://purl.uniprot.org/uniprot/G1ND31 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9103:POLR3A ^@ http://purl.uniprot.org/uniprot/G1N259 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9103:VPS26B ^@ http://purl.uniprot.org/uniprot/G1MS48 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/9103:DYRK2 ^@ http://purl.uniprot.org/uniprot/G1ND88 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9103:MEF2B ^@ http://purl.uniprot.org/uniprot/G1MYT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC100539684 ^@ http://purl.uniprot.org/uniprot/G1N273 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9103:EIF4A2 ^@ http://purl.uniprot.org/uniprot/G3UUH0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/9103:SPO11 ^@ http://purl.uniprot.org/uniprot/G1NA79 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9103:LOC100544306 ^@ http://purl.uniprot.org/uniprot/G3UQI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9103:LOC100543241 ^@ http://purl.uniprot.org/uniprot/G1NQJ6 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9103:OXSM ^@ http://purl.uniprot.org/uniprot/G1NF32 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/9103:SLC7A11 ^@ http://purl.uniprot.org/uniprot/G1MUY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/9103:CUEDC2 ^@ http://purl.uniprot.org/uniprot/G1N578 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:TMEM184A ^@ http://purl.uniprot.org/uniprot/G1MUN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100540209 ^@ http://purl.uniprot.org/uniprot/G1NP38 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9103:LBH ^@ http://purl.uniprot.org/uniprot/G1N1B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9103:MAFA ^@ http://purl.uniprot.org/uniprot/G1NK14 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9103:IL7R ^@ http://purl.uniprot.org/uniprot/G1N9Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/9103:PVALB ^@ http://purl.uniprot.org/uniprot/G1NJ66 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9103:LOC104909279 ^@ http://purl.uniprot.org/uniprot/G3UTY5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9103:KDM3A ^@ http://purl.uniprot.org/uniprot/G3UQM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLC16A3 ^@ http://purl.uniprot.org/uniprot/G1N1R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9103:B3GALT2 ^@ http://purl.uniprot.org/uniprot/G1NQZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:SLC25A20 ^@ http://purl.uniprot.org/uniprot/G1N946 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:UGT8 ^@ http://purl.uniprot.org/uniprot/G1NEF8 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9103:LOC100547944 ^@ http://purl.uniprot.org/uniprot/G1NDJ8 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9103:DOLK ^@ http://purl.uniprot.org/uniprot/G1NRM3 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9103:INHBA ^@ http://purl.uniprot.org/uniprot/A0A803XKY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9103:PGM3 ^@ http://purl.uniprot.org/uniprot/A0A803YBZ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/9103:ALG9 ^@ http://purl.uniprot.org/uniprot/G1MZT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:PPIL2 ^@ http://purl.uniprot.org/uniprot/G1MQY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9103:SRP9 ^@ http://purl.uniprot.org/uniprot/G1N7N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9103:B3GALT5 ^@ http://purl.uniprot.org/uniprot/A0A803YMW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:TRAF1 ^@ http://purl.uniprot.org/uniprot/A0A803YRV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9103:HYLS1 ^@ http://purl.uniprot.org/uniprot/G1MQ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||centriole|||cilium http://togogenome.org/gene/9103:HADHB ^@ http://purl.uniprot.org/uniprot/G1NMT3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9103:MET ^@ http://purl.uniprot.org/uniprot/G1N9U2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:LOC100542253 ^@ http://purl.uniprot.org/uniprot/G3UQA8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:LOC100543573 ^@ http://purl.uniprot.org/uniprot/Q4VTT6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Membrane|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9103:LOC100549606 ^@ http://purl.uniprot.org/uniprot/G3USA9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:TBL1X ^@ http://purl.uniprot.org/uniprot/G1NPE9 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9103:MRAP2 ^@ http://purl.uniprot.org/uniprot/G1NLT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:LOC100538725 ^@ http://purl.uniprot.org/uniprot/G1N332 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9103:GPR107 ^@ http://purl.uniprot.org/uniprot/G1N122 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:MED27 ^@ http://purl.uniprot.org/uniprot/G1N2I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/9103:ATXN1 ^@ http://purl.uniprot.org/uniprot/A0A803XZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9103:KIFC3 ^@ http://purl.uniprot.org/uniprot/G1MW95 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:MTTP ^@ http://purl.uniprot.org/uniprot/A0A803Y1Y8|||http://purl.uniprot.org/uniprot/G1NFF5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:SLCO4A1 ^@ http://purl.uniprot.org/uniprot/G3UR85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:DCAF1 ^@ http://purl.uniprot.org/uniprot/A0A803YFY4|||http://purl.uniprot.org/uniprot/G1MTP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPRBP/DCAF1 family.|||Nucleus http://togogenome.org/gene/9103:LOC100538652 ^@ http://purl.uniprot.org/uniprot/A0A803Y8J2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/9103:MYO19 ^@ http://purl.uniprot.org/uniprot/G1N749 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:LOC100540739 ^@ http://purl.uniprot.org/uniprot/G1N831 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9103:NQO2 ^@ http://purl.uniprot.org/uniprot/G1MZ86 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9103:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A803XTB7|||http://purl.uniprot.org/uniprot/G1MTB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAPGEF2 family.|||Cell junction|||Endosome|||Late endosome|||perinuclear region http://togogenome.org/gene/9103:UBE2I ^@ http://purl.uniprot.org/uniprot/G1N4Y6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/G1N1U1 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9103:MYH11 ^@ http://purl.uniprot.org/uniprot/G1N5L2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:LOC100547680 ^@ http://purl.uniprot.org/uniprot/A0A803XSZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9103:SLC7A1 ^@ http://purl.uniprot.org/uniprot/G1NQC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC104912327 ^@ http://purl.uniprot.org/uniprot/G1N0F1 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/9103:ZNF330 ^@ http://purl.uniprot.org/uniprot/G1MW28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/9103:DPYS ^@ http://purl.uniprot.org/uniprot/G1NID7 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/9103:USP16 ^@ http://purl.uniprot.org/uniprot/G1NNU7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Homotetramer.|||Nucleus|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9103:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A803XP00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9103:ZRANB1 ^@ http://purl.uniprot.org/uniprot/G1NGN3 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9103:PDE5A ^@ http://purl.uniprot.org/uniprot/G1NE52 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:SSH1 ^@ http://purl.uniprot.org/uniprot/G1N2H9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9103:LOC100544807 ^@ http://purl.uniprot.org/uniprot/G3USQ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9103:EIF1B ^@ http://purl.uniprot.org/uniprot/G1NGQ9 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9103:OPTN ^@ http://purl.uniprot.org/uniprot/G1MZZ3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Endosome|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||Vesicle|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9103:CRYBA2 ^@ http://purl.uniprot.org/uniprot/H9H0K9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9103:ESS2 ^@ http://purl.uniprot.org/uniprot/G1N5M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9103:GLCE ^@ http://purl.uniprot.org/uniprot/G1NCS7 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9103:LOC100546836 ^@ http://purl.uniprot.org/uniprot/G1N481 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9103:WDYHV1 ^@ http://purl.uniprot.org/uniprot/G1NJ01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9103:MEGF6 ^@ http://purl.uniprot.org/uniprot/G1MSK3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:VTI1B ^@ http://purl.uniprot.org/uniprot/G1NHA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9103:IMMP1L ^@ http://purl.uniprot.org/uniprot/G1MS34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ACYP1 ^@ http://purl.uniprot.org/uniprot/G1NJC9 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9103:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A803XW36|||http://purl.uniprot.org/uniprot/A0A803YCB2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:ACER2 ^@ http://purl.uniprot.org/uniprot/A0A803XUJ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:LOC100544139 ^@ http://purl.uniprot.org/uniprot/A0A803XZ30|||http://purl.uniprot.org/uniprot/G1NAR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:SLC25A15 ^@ http://purl.uniprot.org/uniprot/G1NQ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:LOC100540027 ^@ http://purl.uniprot.org/uniprot/A0A803Y0G7|||http://purl.uniprot.org/uniprot/G1N2J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/9103:MAFK ^@ http://purl.uniprot.org/uniprot/G1MUM2 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9103:LSM7 ^@ http://purl.uniprot.org/uniprot/A0A803YJS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/9103:ESRP1 ^@ http://purl.uniprot.org/uniprot/A0A803Y5A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESRP family.|||Nucleus http://togogenome.org/gene/9103:LOC100303683 ^@ http://purl.uniprot.org/uniprot/Q91085 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Expressed in pituitary, hypothalamus, small intestine and ovarian follicles.|||Pituitary levels are highest in non-photostimulated and incubating birds and lower in photostimulated, laying and photorefractory birds.|||Pituitary levels decrease on VIP immunization.|||This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9103:LOC100549107 ^@ http://purl.uniprot.org/uniprot/G1NHY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LFNG ^@ http://purl.uniprot.org/uniprot/G1MUY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A803Y421|||http://purl.uniprot.org/uniprot/G1NBI7 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9103:STK40 ^@ http://purl.uniprot.org/uniprot/G1MX03 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/9103:LOC100547695 ^@ http://purl.uniprot.org/uniprot/G1N9R2 ^@ Similarity|||Subunit ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9103:SPP1 ^@ http://purl.uniprot.org/uniprot/G1N6D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9103:CEP44 ^@ http://purl.uniprot.org/uniprot/G1N504 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9103:KATNB1 ^@ http://purl.uniprot.org/uniprot/G1MWV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9103:TM7SF3 ^@ http://purl.uniprot.org/uniprot/G1NLS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:WAPL ^@ http://purl.uniprot.org/uniprot/A0A803XUQ9|||http://purl.uniprot.org/uniprot/G1MUI9 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9103:ACOD1 ^@ http://purl.uniprot.org/uniprot/G1NPY9 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9103:PARP14 ^@ http://purl.uniprot.org/uniprot/G1NI25 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9103:CLP1 ^@ http://purl.uniprot.org/uniprot/G1NBF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9103:SEPTIN9 ^@ http://purl.uniprot.org/uniprot/A0A803YAZ7|||http://purl.uniprot.org/uniprot/A0A803YS64|||http://purl.uniprot.org/uniprot/G1MXP0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9103:HDHD2 ^@ http://purl.uniprot.org/uniprot/G1MZW4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9103:SLC39A6 ^@ http://purl.uniprot.org/uniprot/G1N669 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SUGP2 ^@ http://purl.uniprot.org/uniprot/G1MZ65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:TGM4 ^@ http://purl.uniprot.org/uniprot/G1NGK7 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9103:MYRFL ^@ http://purl.uniprot.org/uniprot/G1NDS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/9103:LOC100550910 ^@ http://purl.uniprot.org/uniprot/G3UQ02 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A803XRK2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:UNC50 ^@ http://purl.uniprot.org/uniprot/A0A803XNF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9103:LACTB2 ^@ http://purl.uniprot.org/uniprot/G1NG16 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9103:SF3B3 ^@ http://purl.uniprot.org/uniprot/G1MS46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:AQP5 ^@ http://purl.uniprot.org/uniprot/G1NDY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9103:RFX2 ^@ http://purl.uniprot.org/uniprot/G1MS51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:HTR5A ^@ http://purl.uniprot.org/uniprot/A0A803YE90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:CNGA3 ^@ http://purl.uniprot.org/uniprot/G1NPJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:COX2 ^@ http://purl.uniprot.org/uniprot/A9XBE2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/G1MYB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A803XPR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:RTF2 ^@ http://purl.uniprot.org/uniprot/G1NAA9 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/9103:CHPF ^@ http://purl.uniprot.org/uniprot/G1NFF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9103:LOC100542155 ^@ http://purl.uniprot.org/uniprot/A0A803Y1N2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:NUSAP1 ^@ http://purl.uniprot.org/uniprot/G1NFB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/9103:HTR4 ^@ http://purl.uniprot.org/uniprot/A0A803Y6H1|||http://purl.uniprot.org/uniprot/A0A803YBK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. http://togogenome.org/gene/9103:TBC1D24 ^@ http://purl.uniprot.org/uniprot/A0A803Y2N0|||http://purl.uniprot.org/uniprot/A0A803Y823 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse|||Synapse http://togogenome.org/gene/9103:ADCY8 ^@ http://purl.uniprot.org/uniprot/G1NJG1|||http://purl.uniprot.org/uniprot/G3UNY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9103:HECTD1 ^@ http://purl.uniprot.org/uniprot/G1NII1 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/9103:LOC100541644 ^@ http://purl.uniprot.org/uniprot/H9H1Y9 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9103:GABRA2 ^@ http://purl.uniprot.org/uniprot/G1NHM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9103:SLC5A3 ^@ http://purl.uniprot.org/uniprot/G1NS73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9103:ADAMTS17 ^@ http://purl.uniprot.org/uniprot/G3UPV2 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:OXTR ^@ http://purl.uniprot.org/uniprot/G1NCK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:IL16 ^@ http://purl.uniprot.org/uniprot/A0A803Y9M7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/9103:PRCP ^@ http://purl.uniprot.org/uniprot/G1NQQ2 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9103:FGF18 ^@ http://purl.uniprot.org/uniprot/G1MS24 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9103:BEST1 ^@ http://purl.uniprot.org/uniprot/G1NB42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Membrane http://togogenome.org/gene/9103:FGGY ^@ http://purl.uniprot.org/uniprot/G1NG87 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9103:GPR12 ^@ http://purl.uniprot.org/uniprot/G1NRD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MRPL32 ^@ http://purl.uniprot.org/uniprot/G1NI71 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9103:TGFBR2 ^@ http://purl.uniprot.org/uniprot/G1NF73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Membrane raft http://togogenome.org/gene/9103:LIMK1 ^@ http://purl.uniprot.org/uniprot/G1MT52 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9103:PRDM12 ^@ http://purl.uniprot.org/uniprot/G1N1G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Involved in the positive regulation of histone H3-K9 dimethylation.|||Nucleus http://togogenome.org/gene/9103:LOC100545895 ^@ http://purl.uniprot.org/uniprot/G1MYM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9103:NPY1R ^@ http://purl.uniprot.org/uniprot/G1MTE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:FBXO32 ^@ http://purl.uniprot.org/uniprot/G1NJ13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:RDH10 ^@ http://purl.uniprot.org/uniprot/G1NG63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9103:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/G1MWB9 ^@ Similarity ^@ Belongs to the CDK2AP family. http://togogenome.org/gene/9103:ETV4 ^@ http://purl.uniprot.org/uniprot/G1MTV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:ING3 ^@ http://purl.uniprot.org/uniprot/G1N979 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9103:DIPK1A ^@ http://purl.uniprot.org/uniprot/G1N7Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:ALAS1 ^@ http://purl.uniprot.org/uniprot/G1MW13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:AZIN1 ^@ http://purl.uniprot.org/uniprot/G1NIA3 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9103:PHGDH ^@ http://purl.uniprot.org/uniprot/G1MZB5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9103:CHFR ^@ http://purl.uniprot.org/uniprot/A0A803XUG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/9103:LOC104912428 ^@ http://purl.uniprot.org/uniprot/G1NGG6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:HSPB9 ^@ http://purl.uniprot.org/uniprot/A0A803YQM6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9103:LHFPL2 ^@ http://purl.uniprot.org/uniprot/G1MZQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TMEM150C ^@ http://purl.uniprot.org/uniprot/G1N7I7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100547331 ^@ http://purl.uniprot.org/uniprot/G1MXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9103:DPY30 ^@ http://purl.uniprot.org/uniprot/G1NFR9 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9103:YAE1 ^@ http://purl.uniprot.org/uniprot/G1NI14 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:KCNH6 ^@ http://purl.uniprot.org/uniprot/G3UTD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100546662 ^@ http://purl.uniprot.org/uniprot/G1MRY6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:PPM1E ^@ http://purl.uniprot.org/uniprot/G1N5H1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9103:SLC17A8 ^@ http://purl.uniprot.org/uniprot/G1NGM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100550809 ^@ http://purl.uniprot.org/uniprot/G1NE03 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9103:TPX2 ^@ http://purl.uniprot.org/uniprot/G1N5U0|||http://purl.uniprot.org/uniprot/G3URR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9103:OSBPL2 ^@ http://purl.uniprot.org/uniprot/G1N1K6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9103:SLC16A5 ^@ http://purl.uniprot.org/uniprot/G1NAS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100547702 ^@ http://purl.uniprot.org/uniprot/G1MZW3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9103:LOC100545341 ^@ http://purl.uniprot.org/uniprot/G3UUQ6 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9103:PARP11 ^@ http://purl.uniprot.org/uniprot/G1NMA8|||http://purl.uniprot.org/uniprot/G1NMA9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9103:SMIM15 ^@ http://purl.uniprot.org/uniprot/G1NS00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9103:TMEM50A ^@ http://purl.uniprot.org/uniprot/G1MT26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9103:CD99L2 ^@ http://purl.uniprot.org/uniprot/G1N7Q0 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9103:LOC100542733 ^@ http://purl.uniprot.org/uniprot/G1NKC5 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9103:LOC104909393 ^@ http://purl.uniprot.org/uniprot/G1NQT2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9103:CAPN3 ^@ http://purl.uniprot.org/uniprot/G1NG52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9103:RSPO4 ^@ http://purl.uniprot.org/uniprot/G1N7G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the R-spondin family.|||Secreted http://togogenome.org/gene/9103:MAFB ^@ http://purl.uniprot.org/uniprot/G1MW90 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9103:LOC100542272 ^@ http://purl.uniprot.org/uniprot/G1NK25 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9103:PAX7 ^@ http://purl.uniprot.org/uniprot/D2KKK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9103:TBP ^@ http://purl.uniprot.org/uniprot/G1NHW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9103:BCL9 ^@ http://purl.uniprot.org/uniprot/G1NNQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9103:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A803XSC5 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/9103:SPC25 ^@ http://purl.uniprot.org/uniprot/G1NDU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9103:BZW2 ^@ http://purl.uniprot.org/uniprot/G1NCM2 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9103:LYRM1 ^@ http://purl.uniprot.org/uniprot/G1ND83 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9103:GIMD1 ^@ http://purl.uniprot.org/uniprot/G1N2J4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9103:SPOPL ^@ http://purl.uniprot.org/uniprot/G1NIU5 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9103:DNAJB14 ^@ http://purl.uniprot.org/uniprot/G1NFH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:OST4 ^@ http://purl.uniprot.org/uniprot/A0A803Y7A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:LOC104914091 ^@ http://purl.uniprot.org/uniprot/A0A803YL81 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9103:MMUT ^@ http://purl.uniprot.org/uniprot/G1NN78 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9103:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A803XLQ0 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9103:SNF8 ^@ http://purl.uniprot.org/uniprot/G1N5F3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/9103:MPP5 ^@ http://purl.uniprot.org/uniprot/G1NHF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||tight junction http://togogenome.org/gene/9103:FADS1 ^@ http://purl.uniprot.org/uniprot/A0A803YDW1 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/9103:SLC30A10 ^@ http://purl.uniprot.org/uniprot/A0A803YJE7|||http://purl.uniprot.org/uniprot/G1NAK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9103:LYVE1 ^@ http://purl.uniprot.org/uniprot/G1N2P7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:BCHE ^@ http://purl.uniprot.org/uniprot/A0A803XNP2|||http://purl.uniprot.org/uniprot/A0A803XRH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9103:GABRA5 ^@ http://purl.uniprot.org/uniprot/G1NPJ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:PSMA2 ^@ http://purl.uniprot.org/uniprot/G1NI68 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9103:EMP2 ^@ http://purl.uniprot.org/uniprot/G1N8I8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9103:DCT ^@ http://purl.uniprot.org/uniprot/G1NPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/9103:PLA2G15 ^@ http://purl.uniprot.org/uniprot/A0A803XMQ0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9103:FUT7 ^@ http://purl.uniprot.org/uniprot/G1MR16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9103:C8H10orf90 ^@ http://purl.uniprot.org/uniprot/G1NGT1 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9103:CORO2A ^@ http://purl.uniprot.org/uniprot/A0A803XY34 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9103:GSTA2 ^@ http://purl.uniprot.org/uniprot/C8BLR4 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9103:CNTN1 ^@ http://purl.uniprot.org/uniprot/G3URJ3 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9103:MFAP1 ^@ http://purl.uniprot.org/uniprot/A0A803XSF8 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9103:NECAP1 ^@ http://purl.uniprot.org/uniprot/G1NMD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9103:MBTPS1 ^@ http://purl.uniprot.org/uniprot/G1MQ93 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9103:TBPL1 ^@ http://purl.uniprot.org/uniprot/G3UQK3 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/9103:BRINP2 ^@ http://purl.uniprot.org/uniprot/G1MU49 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9103:LOC104909450 ^@ http://purl.uniprot.org/uniprot/A0A803YPC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:IDS ^@ http://purl.uniprot.org/uniprot/G1N835 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9103:THEMIS2 ^@ http://purl.uniprot.org/uniprot/G1MQX9 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9103:DLK2 ^@ http://purl.uniprot.org/uniprot/G1NEW7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:IRF6 ^@ http://purl.uniprot.org/uniprot/G1MZ34 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:NDUFV1 ^@ http://purl.uniprot.org/uniprot/G1MY60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:MLH1 ^@ http://purl.uniprot.org/uniprot/G1NH97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9103:FAM20B ^@ http://purl.uniprot.org/uniprot/G1MUV3 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9103:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A803Y4B8|||http://purl.uniprot.org/uniprot/G1NMM8 ^@ Subcellular Location Annotation ^@ centrosome|||cilium basal body http://togogenome.org/gene/9103:CAPN6 ^@ http://purl.uniprot.org/uniprot/G1N408 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9103:TCP11L2 ^@ http://purl.uniprot.org/uniprot/G1NJQ5 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9103:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A803YMW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9103:EIF2D ^@ http://purl.uniprot.org/uniprot/G1MX71 ^@ Similarity ^@ Belongs to the eIF2D family. http://togogenome.org/gene/9103:LOC100540190 ^@ http://purl.uniprot.org/uniprot/G1MZV0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:CACNG1 ^@ http://purl.uniprot.org/uniprot/G1N671 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9103:CUL5 ^@ http://purl.uniprot.org/uniprot/G1NQH7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9103:PNPLA1 ^@ http://purl.uniprot.org/uniprot/A0A803YFY0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:FOXI1 ^@ http://purl.uniprot.org/uniprot/G1MT33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A803XN50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100547732 ^@ http://purl.uniprot.org/uniprot/G1N5H4 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/9103:RUVBL1 ^@ http://purl.uniprot.org/uniprot/G1N5W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9103:CKAP2L ^@ http://purl.uniprot.org/uniprot/A0A803Y4M2 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9103:SLC25A22 ^@ http://purl.uniprot.org/uniprot/G1NA56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:CENPO ^@ http://purl.uniprot.org/uniprot/G1NMX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/9103:LOC100544555 ^@ http://purl.uniprot.org/uniprot/G1NKH5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:TIMP2 ^@ http://purl.uniprot.org/uniprot/G3UTJ0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9103:UNC93B1 ^@ http://purl.uniprot.org/uniprot/G1MXZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9103:TFDP1 ^@ http://purl.uniprot.org/uniprot/G1NPR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9103:N4BP3 ^@ http://purl.uniprot.org/uniprot/G1MY75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Cytoplasmic vesicle|||Vesicle|||axon|||dendrite http://togogenome.org/gene/9103:PPP1R3B ^@ http://purl.uniprot.org/uniprot/G1NAF2 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/9103:PDE8B ^@ http://purl.uniprot.org/uniprot/G1MZV8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:KCNE1 ^@ http://purl.uniprot.org/uniprot/G1NS78 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9103:LOC100546986 ^@ http://purl.uniprot.org/uniprot/G1MWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A803YCB5 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9103:TMEM14A ^@ http://purl.uniprot.org/uniprot/G3UP93 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9103:OGFR ^@ http://purl.uniprot.org/uniprot/A0A803Y6A5|||http://purl.uniprot.org/uniprot/G1N2F7 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/9103:GCHFR ^@ http://purl.uniprot.org/uniprot/G1MVC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9103:TES ^@ http://purl.uniprot.org/uniprot/G1N9U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||focal adhesion http://togogenome.org/gene/9103:SKIL ^@ http://purl.uniprot.org/uniprot/G1NCS6 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/9103:NDST1 ^@ http://purl.uniprot.org/uniprot/G1N466 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9103:SERPINF1 ^@ http://purl.uniprot.org/uniprot/G1N131 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:MED7 ^@ http://purl.uniprot.org/uniprot/G1NR47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9103:EVA1C ^@ http://purl.uniprot.org/uniprot/G1NNW4 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9103:LOC100550717 ^@ http://purl.uniprot.org/uniprot/A0A803YKP7|||http://purl.uniprot.org/uniprot/G1MU12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:MIGA2 ^@ http://purl.uniprot.org/uniprot/G1N030 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9103:ELOVL2 ^@ http://purl.uniprot.org/uniprot/G1MWP1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9103:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A803XZI3 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9103:CRYGN ^@ http://purl.uniprot.org/uniprot/G1MZB4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9103:MFSD14A ^@ http://purl.uniprot.org/uniprot/G1N5D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9103:EFTUD2 ^@ http://purl.uniprot.org/uniprot/G1NCI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Nucleus http://togogenome.org/gene/9103:ASXL2 ^@ http://purl.uniprot.org/uniprot/G1NMS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/9103:ABCG2 ^@ http://purl.uniprot.org/uniprot/G1N6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Cell membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9103:CSNK1G2 ^@ http://purl.uniprot.org/uniprot/G1MTK4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:VPS54 ^@ http://purl.uniprot.org/uniprot/G1MZY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/9103:YOD1 ^@ http://purl.uniprot.org/uniprot/G1NRG4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/9103:CAT ^@ http://purl.uniprot.org/uniprot/G1NCW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9103:BTD ^@ http://purl.uniprot.org/uniprot/G1NED4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9103:SPDEF ^@ http://purl.uniprot.org/uniprot/H9H0G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9103:SGMS2 ^@ http://purl.uniprot.org/uniprot/G1N2G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9103:SLC19A1 ^@ http://purl.uniprot.org/uniprot/G1MSY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||Transporter that mediates the import of reduced folates. http://togogenome.org/gene/9103:GALK2 ^@ http://purl.uniprot.org/uniprot/G3UUW9 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9103:FGFBP2 ^@ http://purl.uniprot.org/uniprot/G1NJ27 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9103:FAM160A1 ^@ http://purl.uniprot.org/uniprot/G1MYL4 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9103:C20H17orf80 ^@ http://purl.uniprot.org/uniprot/A0A803YD61 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/9103:VAMP7 ^@ http://purl.uniprot.org/uniprot/G1N185 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9103:PPP4R3A ^@ http://purl.uniprot.org/uniprot/G1NK92 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9103:HNRNPK ^@ http://purl.uniprot.org/uniprot/G1N3K4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/9103:ATP6AP1L ^@ http://purl.uniprot.org/uniprot/G1MXT4 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9103:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A803Y1D9|||http://purl.uniprot.org/uniprot/G1NIG9 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9103:GPX1 ^@ http://purl.uniprot.org/uniprot/D2J267 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9103:HOXB3 ^@ http://purl.uniprot.org/uniprot/G1MUE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9103:UCKL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y1X3|||http://purl.uniprot.org/uniprot/A0A803Y3S2|||http://purl.uniprot.org/uniprot/G1N4H4 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9103:MRPL27 ^@ http://purl.uniprot.org/uniprot/G1NA99 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9103:IAPP ^@ http://purl.uniprot.org/uniprot/G1NLJ8 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9103:FGF8 ^@ http://purl.uniprot.org/uniprot/G1NQY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Secreted http://togogenome.org/gene/9103:ACLY ^@ http://purl.uniprot.org/uniprot/A0A803YFY1|||http://purl.uniprot.org/uniprot/G1MW07 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9103:PLAU ^@ http://purl.uniprot.org/uniprot/G1N3G3 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. http://togogenome.org/gene/9103:LOC100543795 ^@ http://purl.uniprot.org/uniprot/A0A803YGR5 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/9103:TNFAIP2 ^@ http://purl.uniprot.org/uniprot/G1NL04 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9103:RPL37A ^@ http://purl.uniprot.org/uniprot/G1NGI8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9103:LOC100542243 ^@ http://purl.uniprot.org/uniprot/A0A803YD13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9103:NXPE3 ^@ http://purl.uniprot.org/uniprot/G1NNI7 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9103:GMFB ^@ http://purl.uniprot.org/uniprot/A0A803YQK9 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9103:LOC100541666 ^@ http://purl.uniprot.org/uniprot/G1N764 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9103:LOC100541326 ^@ http://purl.uniprot.org/uniprot/G3UPG3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CA10 ^@ http://purl.uniprot.org/uniprot/A0A803YG02 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9103:SLC16A1 ^@ http://purl.uniprot.org/uniprot/G1N0P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane|||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. http://togogenome.org/gene/9103:COG4 ^@ http://purl.uniprot.org/uniprot/G1MS27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9103:RPL15 ^@ http://purl.uniprot.org/uniprot/G1NEU5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9103:ZEB2 ^@ http://purl.uniprot.org/uniprot/G1NJ41 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9103:LOC104913587 ^@ http://purl.uniprot.org/uniprot/A0A803XLQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9103:FAM83H ^@ http://purl.uniprot.org/uniprot/H9H1W5 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9103:TCTE3 ^@ http://purl.uniprot.org/uniprot/G1NHZ0 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9103:MSANTD3 ^@ http://purl.uniprot.org/uniprot/G1N6K8 ^@ Similarity ^@ Belongs to the MSANTD3 family. http://togogenome.org/gene/9103:DUSP16 ^@ http://purl.uniprot.org/uniprot/G1NM65 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9103:PAX6 ^@ http://purl.uniprot.org/uniprot/G1MS18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9103:XKR5 ^@ http://purl.uniprot.org/uniprot/G1NN40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9103:CREM ^@ http://purl.uniprot.org/uniprot/G1N2F5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC109368447 ^@ http://purl.uniprot.org/uniprot/G1MX54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9103:RPL3L ^@ http://purl.uniprot.org/uniprot/G1N1V3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9103:CAMTA1 ^@ http://purl.uniprot.org/uniprot/A0A803XX96|||http://purl.uniprot.org/uniprot/A0A803Y0F6|||http://purl.uniprot.org/uniprot/G1MQR7 ^@ Similarity|||Subunit ^@ Belongs to the CAMTA family.|||May interact with calmodulin. http://togogenome.org/gene/9103:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A803XPY2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9103:SLC25A42 ^@ http://purl.uniprot.org/uniprot/A0A803Y9E3|||http://purl.uniprot.org/uniprot/G1MZ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:FUNDC1 ^@ http://purl.uniprot.org/uniprot/G1NP36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9103:CLVS1 ^@ http://purl.uniprot.org/uniprot/G1NF59 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9103:SNCG ^@ http://purl.uniprot.org/uniprot/G1MU41 ^@ Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. http://togogenome.org/gene/9103:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/G1NJK6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/G1NMK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9103:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/G1NM07 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9103:ANXA7 ^@ http://purl.uniprot.org/uniprot/G1N4G4 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9103:IL1RN ^@ http://purl.uniprot.org/uniprot/A3DTN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9103:FNIP1 ^@ http://purl.uniprot.org/uniprot/G1N948 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A803YGZ4|||http://purl.uniprot.org/uniprot/G1N9J5|||http://purl.uniprot.org/uniprot/G1N9J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9103:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A803Y586 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9103:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A803YFB2|||http://purl.uniprot.org/uniprot/A0A803YSU9|||http://purl.uniprot.org/uniprot/G1NDC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||Required for ciliogenesis.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9103:TFB1M ^@ http://purl.uniprot.org/uniprot/G1NJG6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9103:SAR1B ^@ http://purl.uniprot.org/uniprot/G1N8D5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9103:LOC100550479 ^@ http://purl.uniprot.org/uniprot/A0A803Y3M4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LOC100539535 ^@ http://purl.uniprot.org/uniprot/G1MQH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9103:LOC104914423 ^@ http://purl.uniprot.org/uniprot/A0A803XM33 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9103:PSAP ^@ http://purl.uniprot.org/uniprot/G1MZV1 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/9103:NR1D2 ^@ http://purl.uniprot.org/uniprot/G1NEW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:SLITRK5 ^@ http://purl.uniprot.org/uniprot/A0A803XKT0 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9103:TADA2A ^@ http://purl.uniprot.org/uniprot/G1N7M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:TP53INP1 ^@ http://purl.uniprot.org/uniprot/G1NHN1 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9103:BRS3 ^@ http://purl.uniprot.org/uniprot/G1MWV2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9103:LOC100541145 ^@ http://purl.uniprot.org/uniprot/G1NKL1 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9103:LOC100541319 ^@ http://purl.uniprot.org/uniprot/A0A803YMB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9103:NMB ^@ http://purl.uniprot.org/uniprot/G1MQK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted http://togogenome.org/gene/9103:RSBN1 ^@ http://purl.uniprot.org/uniprot/G1N0P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9103:CHST1 ^@ http://purl.uniprot.org/uniprot/G1NRP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9103:ZNF326 ^@ http://purl.uniprot.org/uniprot/G1N8P6 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9103:CFLAR ^@ http://purl.uniprot.org/uniprot/G1N708 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9103:TMC6 ^@ http://purl.uniprot.org/uniprot/G1N272 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9103:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A803XYP9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9103:ADAMTS10 ^@ http://purl.uniprot.org/uniprot/G1MSN8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9103:CASK ^@ http://purl.uniprot.org/uniprot/A0A803XUJ1|||http://purl.uniprot.org/uniprot/A0A803YEH6|||http://purl.uniprot.org/uniprot/A0A803YJ82|||http://purl.uniprot.org/uniprot/G1NP41 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9103:SERPINA1 ^@ http://purl.uniprot.org/uniprot/G1NKH9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:PARN ^@ http://purl.uniprot.org/uniprot/G1MQS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:TACR2 ^@ http://purl.uniprot.org/uniprot/G1MZ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A803XZB0|||http://purl.uniprot.org/uniprot/G1N985|||http://purl.uniprot.org/uniprot/G3UUR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:STARD3 ^@ http://purl.uniprot.org/uniprot/H9H1G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9103:CRYZ ^@ http://purl.uniprot.org/uniprot/G1NHT0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9103:PPDPF ^@ http://purl.uniprot.org/uniprot/G1N3X5 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9103:ALDOC ^@ http://purl.uniprot.org/uniprot/G1N2A4 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9103:TMOD4 ^@ http://purl.uniprot.org/uniprot/G1MQX4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9103:MASP1 ^@ http://purl.uniprot.org/uniprot/G1N6P6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CENPM ^@ http://purl.uniprot.org/uniprot/G1NHN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:NCLN ^@ http://purl.uniprot.org/uniprot/G1MR79 ^@ Similarity ^@ Belongs to the nicastrin family. http://togogenome.org/gene/9103:SS18L1 ^@ http://purl.uniprot.org/uniprot/G1N1D5 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9103:AP2B1 ^@ http://purl.uniprot.org/uniprot/G1MY27 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9103:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A803YK75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9103:RAB3IP ^@ http://purl.uniprot.org/uniprot/A0A803Y961 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9103:SEMA7A ^@ http://purl.uniprot.org/uniprot/A0A803YJ66|||http://purl.uniprot.org/uniprot/G1MUM7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:STC2 ^@ http://purl.uniprot.org/uniprot/A0A803XRK5 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9103:KCNE4 ^@ http://purl.uniprot.org/uniprot/G1N023 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9103:TAF13 ^@ http://purl.uniprot.org/uniprot/G1NNE7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:HAL ^@ http://purl.uniprot.org/uniprot/G1NG29 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9103:WNT7A ^@ http://purl.uniprot.org/uniprot/G1N1F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9103:ARVCF ^@ http://purl.uniprot.org/uniprot/A0A803XKG3|||http://purl.uniprot.org/uniprot/G1MRS8 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9103:ERO1A ^@ http://purl.uniprot.org/uniprot/G1NM09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/G1MUC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Cytoplasm http://togogenome.org/gene/9103:SLC52A3 ^@ http://purl.uniprot.org/uniprot/G1MQV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9103:LOC100544485 ^@ http://purl.uniprot.org/uniprot/G1NQJ4 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9103:STAT4 ^@ http://purl.uniprot.org/uniprot/G3UU36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:MIS18A ^@ http://purl.uniprot.org/uniprot/G1NNV5 ^@ Function|||Subcellular Location Annotation ^@ Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9103:MSH2 ^@ http://purl.uniprot.org/uniprot/G1N0T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/9103:CRYBG1 ^@ http://purl.uniprot.org/uniprot/A0A803XVY5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9103:LOC100544729 ^@ http://purl.uniprot.org/uniprot/G1NBE5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9103:ATP23 ^@ http://purl.uniprot.org/uniprot/G1NCB2 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9103:MCOLN2 ^@ http://purl.uniprot.org/uniprot/G1N9Z2 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9103:MADCAM1 ^@ http://purl.uniprot.org/uniprot/A0A803YC33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9103:TPRA1 ^@ http://purl.uniprot.org/uniprot/G1N6A4|||http://purl.uniprot.org/uniprot/G3US44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9103:PYGL ^@ http://purl.uniprot.org/uniprot/G1NLY5 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9103:NEDD9 ^@ http://purl.uniprot.org/uniprot/G1MWJ5|||http://purl.uniprot.org/uniprot/G3UNW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9103:NDUFA8 ^@ http://purl.uniprot.org/uniprot/G3UQB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9103:STXBP5 ^@ http://purl.uniprot.org/uniprot/G1NIX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9103:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/G1MY94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A803Y2G2 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9103:FGF23 ^@ http://purl.uniprot.org/uniprot/G1NM86 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9103:IFNG ^@ http://purl.uniprot.org/uniprot/G1NDA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|||Secreted http://togogenome.org/gene/9103:LOC100550136 ^@ http://purl.uniprot.org/uniprot/G1MW46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9103:LOC100542070 ^@ http://purl.uniprot.org/uniprot/G1NKI3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:HS3ST1 ^@ http://purl.uniprot.org/uniprot/G3UQ78 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:MYO1F ^@ http://purl.uniprot.org/uniprot/G1MSJ5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:LOC100541720 ^@ http://purl.uniprot.org/uniprot/G1MZZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/9103:ADD1 ^@ http://purl.uniprot.org/uniprot/A0A803Y0R2 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9103:TPT1 ^@ http://purl.uniprot.org/uniprot/G1NQ36 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9103:MCL1 ^@ http://purl.uniprot.org/uniprot/G1MPY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Membrane|||nucleoplasm http://togogenome.org/gene/9103:SLC25A17 ^@ http://purl.uniprot.org/uniprot/G1NI83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:RPS7 ^@ http://purl.uniprot.org/uniprot/G1NMH4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/9103:CD3E ^@ http://purl.uniprot.org/uniprot/G1MXY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GPRC5B ^@ http://purl.uniprot.org/uniprot/G1NC23 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:C7H2orf88 ^@ http://purl.uniprot.org/uniprot/A0A803Y6B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100541738 ^@ http://purl.uniprot.org/uniprot/A0A803XME0|||http://purl.uniprot.org/uniprot/G1NRJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:KCNJ6 ^@ http://purl.uniprot.org/uniprot/G1NNY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9103:GHSR ^@ http://purl.uniprot.org/uniprot/G1NCC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). http://togogenome.org/gene/9103:TOM1 ^@ http://purl.uniprot.org/uniprot/G1NJE2 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9103:AADAC ^@ http://purl.uniprot.org/uniprot/G1NEI5 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9103:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A803Y8R8 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9103:RXFP1 ^@ http://purl.uniprot.org/uniprot/G1MSR7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:UBE2F ^@ http://purl.uniprot.org/uniprot/G1MW30 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:RPL5 ^@ http://purl.uniprot.org/uniprot/G1N7T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9103:TASOR2 ^@ http://purl.uniprot.org/uniprot/A0A803YQR8 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9103:LOC100539041 ^@ http://purl.uniprot.org/uniprot/G5E7U3 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9103:LOC100541166 ^@ http://purl.uniprot.org/uniprot/G1MWU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9103:KIF26B ^@ http://purl.uniprot.org/uniprot/G1NFX3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:TRADD ^@ http://purl.uniprot.org/uniprot/A0A803XSX1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/G1NNG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:TMEM129 ^@ http://purl.uniprot.org/uniprot/G3UQR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9103:GATB ^@ http://purl.uniprot.org/uniprot/G1MYM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9103:EZH1 ^@ http://purl.uniprot.org/uniprot/G1MY19 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:TASOR ^@ http://purl.uniprot.org/uniprot/G1N381 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9103:FICD ^@ http://purl.uniprot.org/uniprot/G1N250 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9103:SEC23B ^@ http://purl.uniprot.org/uniprot/G1N4G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9103:CTSE ^@ http://purl.uniprot.org/uniprot/G1MWJ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Endosome|||Homodimer; disulfide-linked. http://togogenome.org/gene/9103:KCNJ4 ^@ http://purl.uniprot.org/uniprot/G1NIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9103:LOC100548731 ^@ http://purl.uniprot.org/uniprot/G1NKH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PDE6G ^@ http://purl.uniprot.org/uniprot/G1N3U3 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9103:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A803YEG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/9103:TMEM30A ^@ http://purl.uniprot.org/uniprot/G1NM03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC50/LEM3 family.|||Cell membrane|||Golgi apparatus|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9103:DOLPP1 ^@ http://purl.uniprot.org/uniprot/G1N041 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9103:LOC100542338 ^@ http://purl.uniprot.org/uniprot/G1MQ72|||http://purl.uniprot.org/uniprot/G3UV43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9103:GJC2 ^@ http://purl.uniprot.org/uniprot/A0A803YC75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9103:PIAS4 ^@ http://purl.uniprot.org/uniprot/G1NF86 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9103:CDX1 ^@ http://purl.uniprot.org/uniprot/G1N4V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9103:ST7 ^@ http://purl.uniprot.org/uniprot/A0A803YSG9|||http://purl.uniprot.org/uniprot/G1N9N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9103:CPEB1 ^@ http://purl.uniprot.org/uniprot/A0A803XTH2|||http://purl.uniprot.org/uniprot/G1MRN5 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9103:DNAJA4 ^@ http://purl.uniprot.org/uniprot/G1MXG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:TRMT6 ^@ http://purl.uniprot.org/uniprot/G1N6T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/9103:CENPU ^@ http://purl.uniprot.org/uniprot/G1N3I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/9103:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/A0A803YPL5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle http://togogenome.org/gene/9103:GLI1 ^@ http://purl.uniprot.org/uniprot/A0A803XYT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9103:ZBED4 ^@ http://purl.uniprot.org/uniprot/A0A803XZF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:TNFSF13B ^@ http://purl.uniprot.org/uniprot/G1NPT6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9103:BRPF1 ^@ http://purl.uniprot.org/uniprot/G1N8B5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LOC723978 ^@ http://purl.uniprot.org/uniprot/Q71SZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100542821 ^@ http://purl.uniprot.org/uniprot/A0A803Y0Z2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:BCL2L14 ^@ http://purl.uniprot.org/uniprot/G3UPV4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9103:CEP55 ^@ http://purl.uniprot.org/uniprot/G1N9K8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:RPAP1 ^@ http://purl.uniprot.org/uniprot/G1NFG8 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9103:LOC100544408 ^@ http://purl.uniprot.org/uniprot/G1N766 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9103:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/G1N6J4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:MAN2C1 ^@ http://purl.uniprot.org/uniprot/G1MVW3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/9103:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A803XQ49|||http://purl.uniprot.org/uniprot/G1N6Y1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9103:SF3B1 ^@ http://purl.uniprot.org/uniprot/G1N5C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9103:LOC100539135 ^@ http://purl.uniprot.org/uniprot/A0A803XPE6|||http://purl.uniprot.org/uniprot/G3UUW5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9103:NT5C3A ^@ http://purl.uniprot.org/uniprot/G1NHM7|||http://purl.uniprot.org/uniprot/G3UQB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9103:TRRAP ^@ http://purl.uniprot.org/uniprot/A0A803YM31 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. TRA1 subfamily. http://togogenome.org/gene/9103:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/G1NIH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9103:NIPAL2 ^@ http://purl.uniprot.org/uniprot/G1NHV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9103:LOC100550794 ^@ http://purl.uniprot.org/uniprot/A0A803YJQ5 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9103:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A803YE65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9103:EREG ^@ http://purl.uniprot.org/uniprot/G1N5J0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:RRAD ^@ http://purl.uniprot.org/uniprot/G1N3C8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9103:ELOA ^@ http://purl.uniprot.org/uniprot/A0A803YR68|||http://purl.uniprot.org/uniprot/G1N1V8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:LIN7C ^@ http://purl.uniprot.org/uniprot/G1NJI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/9103:NELFCD ^@ http://purl.uniprot.org/uniprot/G3URE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/9103:SHCBP1 ^@ http://purl.uniprot.org/uniprot/G1N165 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9103:IRF1 ^@ http://purl.uniprot.org/uniprot/G1N9T6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9103:PRPF3 ^@ http://purl.uniprot.org/uniprot/G1MPX0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9103:RAX2 ^@ http://purl.uniprot.org/uniprot/G1MQF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9103:AOX1 ^@ http://purl.uniprot.org/uniprot/G1N6E5|||http://purl.uniprot.org/uniprot/M1ZMM2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9103:NAPG ^@ http://purl.uniprot.org/uniprot/G1N9W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9103:INO80C ^@ http://purl.uniprot.org/uniprot/G1N4F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:XKR9 ^@ http://purl.uniprot.org/uniprot/G1NG19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9103:CEMIP ^@ http://purl.uniprot.org/uniprot/G1N7U1 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9103:PLA1A ^@ http://purl.uniprot.org/uniprot/A0A803XQ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9103:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A803YDB5|||http://purl.uniprot.org/uniprot/G1MY90|||http://purl.uniprot.org/uniprot/G5E808 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ANAPC16 ^@ http://purl.uniprot.org/uniprot/G1N1E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9103:EGR1 ^@ http://purl.uniprot.org/uniprot/G1NB71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9103:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A803Y5J7|||http://purl.uniprot.org/uniprot/A0A803YRT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9103:RPS15A ^@ http://purl.uniprot.org/uniprot/G1N6V8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit. http://togogenome.org/gene/9103:PRKCQ ^@ http://purl.uniprot.org/uniprot/G1MY89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9103:GNA11 ^@ http://purl.uniprot.org/uniprot/P45645 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||Cell membrane|||Cytoplasm|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. http://togogenome.org/gene/9103:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A803YGL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9103:LMOD2 ^@ http://purl.uniprot.org/uniprot/G1N8E8 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9103:SLC41A2 ^@ http://purl.uniprot.org/uniprot/G1NJV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9103:S1PR1 ^@ http://purl.uniprot.org/uniprot/G3UQ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100541867 ^@ http://purl.uniprot.org/uniprot/A0A803XNZ9|||http://purl.uniprot.org/uniprot/G1MYM8 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9103:AP1G1 ^@ http://purl.uniprot.org/uniprot/G1N9R9|||http://purl.uniprot.org/uniprot/G5E7Y2 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9103:SERPINB1 ^@ http://purl.uniprot.org/uniprot/G1MYU4 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9103:ALOX5 ^@ http://purl.uniprot.org/uniprot/G1N6U6 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:SEPTIN6 ^@ http://purl.uniprot.org/uniprot/G1N6Z5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9103:SLC6A7 ^@ http://purl.uniprot.org/uniprot/G1N4T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9103:ATPSCKMT ^@ http://purl.uniprot.org/uniprot/G1N388 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/9103:SLCO4C1 ^@ http://purl.uniprot.org/uniprot/A0A803XTC2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:RNF8 ^@ http://purl.uniprot.org/uniprot/G1NE57 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHFR family.|||Belongs to the RNF8 family.|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2.|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1. http://togogenome.org/gene/9103:CHRDL1 ^@ http://purl.uniprot.org/uniprot/G1N427 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:CBFB ^@ http://purl.uniprot.org/uniprot/A0A803YQV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/9103:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A803XMA9|||http://purl.uniprot.org/uniprot/G1NLR5 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9103:NETO1 ^@ http://purl.uniprot.org/uniprot/G1N880 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100541604 ^@ http://purl.uniprot.org/uniprot/G3UPG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100543595 ^@ http://purl.uniprot.org/uniprot/A0A803XME0|||http://purl.uniprot.org/uniprot/G1NRJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:LOC100540299 ^@ http://purl.uniprot.org/uniprot/A0A803YRL7|||http://purl.uniprot.org/uniprot/G1N455 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CD109 ^@ http://purl.uniprot.org/uniprot/G1NM32 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. http://togogenome.org/gene/9103:TMEM120B ^@ http://purl.uniprot.org/uniprot/G1MYX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9103:TSPAN1 ^@ http://purl.uniprot.org/uniprot/G1NDT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9103:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/G1MTC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:DUT ^@ http://purl.uniprot.org/uniprot/G1N547 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/9103:GINS2 ^@ http://purl.uniprot.org/uniprot/G1N6D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9103:BRD1 ^@ http://purl.uniprot.org/uniprot/A0A803XZW3|||http://purl.uniprot.org/uniprot/A0A803YCW8|||http://purl.uniprot.org/uniprot/G1N711 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:TEF ^@ http://purl.uniprot.org/uniprot/G1NI36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9103:BCO2 ^@ http://purl.uniprot.org/uniprot/G1MZC3 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9103:SLC37A3 ^@ http://purl.uniprot.org/uniprot/G1NKI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9103:LOC100542122 ^@ http://purl.uniprot.org/uniprot/A0A803YAC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9103:SSU72 ^@ http://purl.uniprot.org/uniprot/G1MUU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9103:LOC100545337 ^@ http://purl.uniprot.org/uniprot/G1N7P3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:SLC7A4 ^@ http://purl.uniprot.org/uniprot/G1NB48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A803XXI9|||http://purl.uniprot.org/uniprot/G1NK76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SLC39A9 ^@ http://purl.uniprot.org/uniprot/G1NH09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||May act as a zinc-influx transporter.|||Membrane http://togogenome.org/gene/9103:TRPM2 ^@ http://purl.uniprot.org/uniprot/G1MY44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100547762 ^@ http://purl.uniprot.org/uniprot/G1MSE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9103:CDH13 ^@ http://purl.uniprot.org/uniprot/A0A803XSE0|||http://purl.uniprot.org/uniprot/G1N572 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.|||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100540050 ^@ http://purl.uniprot.org/uniprot/G1NRI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A803XWE4|||http://purl.uniprot.org/uniprot/A0A803Y5B0|||http://purl.uniprot.org/uniprot/G1MU82 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:GALNT1 ^@ http://purl.uniprot.org/uniprot/G1N4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:PLCG2 ^@ http://purl.uniprot.org/uniprot/G1N518 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9103:BTBD10 ^@ http://purl.uniprot.org/uniprot/G1N179 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:GPCPD1 ^@ http://purl.uniprot.org/uniprot/G1N6Q8 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9103:MMD ^@ http://purl.uniprot.org/uniprot/A0A803YK29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9103:ACTR3 ^@ http://purl.uniprot.org/uniprot/G1NIH4 ^@ Similarity ^@ Belongs to the actin family. ARP3 subfamily. http://togogenome.org/gene/9103:ITIH2 ^@ http://purl.uniprot.org/uniprot/G1MYY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9103:CDK10 ^@ http://purl.uniprot.org/uniprot/G1N7X1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:LECT2 ^@ http://purl.uniprot.org/uniprot/G3URY4 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9103:GRB2 ^@ http://purl.uniprot.org/uniprot/G1NB29 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9103:RIPOR1 ^@ http://purl.uniprot.org/uniprot/G1MTS0 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9103:PTDSS1 ^@ http://purl.uniprot.org/uniprot/G1NHQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:RPLP1 ^@ http://purl.uniprot.org/uniprot/G1NJV2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9103:SLC7A14 ^@ http://purl.uniprot.org/uniprot/G1NCR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:MEF2D ^@ http://purl.uniprot.org/uniprot/A0A803Y0Y9|||http://purl.uniprot.org/uniprot/G1MPS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:AASDHPPT ^@ http://purl.uniprot.org/uniprot/G1NQI4 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/9103:IL18 ^@ http://purl.uniprot.org/uniprot/G1MZF3|||http://purl.uniprot.org/uniprot/Q8AV26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Secreted http://togogenome.org/gene/9103:JAGN1 ^@ http://purl.uniprot.org/uniprot/G1N8L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:MGMT ^@ http://purl.uniprot.org/uniprot/A0A803YCD1|||http://purl.uniprot.org/uniprot/G1NGZ4 ^@ Similarity ^@ Belongs to the MGMT family. http://togogenome.org/gene/9103:RRN3 ^@ http://purl.uniprot.org/uniprot/G3UQA6 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/9103:LOC100540439 ^@ http://purl.uniprot.org/uniprot/A0A803YE04 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:FAM162B ^@ http://purl.uniprot.org/uniprot/G1NKY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9103:SMC6 ^@ http://purl.uniprot.org/uniprot/G1NMM3 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9103:TRIQK ^@ http://purl.uniprot.org/uniprot/G1NHC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:POC5 ^@ http://purl.uniprot.org/uniprot/G1N061 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/9103:MGST2 ^@ http://purl.uniprot.org/uniprot/G1MV99 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9103:GPAT3 ^@ http://purl.uniprot.org/uniprot/A0A803Y3Y1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9103:LOC100542219 ^@ http://purl.uniprot.org/uniprot/G1N6L0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:ELAVL1 ^@ http://purl.uniprot.org/uniprot/G1MQP8|||http://purl.uniprot.org/uniprot/G3UQU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9103:SLC1A6 ^@ http://purl.uniprot.org/uniprot/A0A803XUX7|||http://purl.uniprot.org/uniprot/G1MQ46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9103:SLC24A2 ^@ http://purl.uniprot.org/uniprot/A0A803Y5F8|||http://purl.uniprot.org/uniprot/G3UR01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9103:MEMO1 ^@ http://purl.uniprot.org/uniprot/G1NFS7 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/9103:LOC100550056 ^@ http://purl.uniprot.org/uniprot/G1MTF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9103:SEC22B ^@ http://purl.uniprot.org/uniprot/G1MZU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:PLXNA4 ^@ http://purl.uniprot.org/uniprot/G1MXM0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:ZC3H14 ^@ http://purl.uniprot.org/uniprot/G1NK12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZC3H14 family.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/9103:RFTN2 ^@ http://purl.uniprot.org/uniprot/G1N5K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100546187 ^@ http://purl.uniprot.org/uniprot/G1NCT3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9103:PPDPFL ^@ http://purl.uniprot.org/uniprot/A0A803YKW9 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9103:SLC35F1 ^@ http://purl.uniprot.org/uniprot/G1NKW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9103:LOC100550719 ^@ http://purl.uniprot.org/uniprot/A0A803YNS9 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/9103:ACTN1 ^@ http://purl.uniprot.org/uniprot/G1NH44 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9103:STK3 ^@ http://purl.uniprot.org/uniprot/G1NHW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9103:CILP ^@ http://purl.uniprot.org/uniprot/G1NBA9 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9103:LOC100538829 ^@ http://purl.uniprot.org/uniprot/G1NGS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9103:ACVR1C ^@ http://purl.uniprot.org/uniprot/G1NJQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9103:LOC100550171 ^@ http://purl.uniprot.org/uniprot/G1NS25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:ZPR1 ^@ http://purl.uniprot.org/uniprot/A0A803XYX6 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9103:SPINK2 ^@ http://purl.uniprot.org/uniprot/Q5GMQ7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:LRRC8B ^@ http://purl.uniprot.org/uniprot/G1N8Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GKAP1 ^@ http://purl.uniprot.org/uniprot/A0A803YL03|||http://purl.uniprot.org/uniprot/A0A803YMU4 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9103:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A803XXS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:NSF ^@ http://purl.uniprot.org/uniprot/A0A803YM82 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9103:MRTO4 ^@ http://purl.uniprot.org/uniprot/G1N1B1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9103:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A803Y7D8|||http://purl.uniprot.org/uniprot/G1MYK1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:SEMA3D ^@ http://purl.uniprot.org/uniprot/G1N178 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100540103 ^@ http://purl.uniprot.org/uniprot/G1N7N4 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LOC100545080 ^@ http://purl.uniprot.org/uniprot/G1MQ26 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9103:CHRNA4 ^@ http://purl.uniprot.org/uniprot/G1N3L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:LOC104910884 ^@ http://purl.uniprot.org/uniprot/A0A803XTL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9103:LOC100540396 ^@ http://purl.uniprot.org/uniprot/G1N5T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9103:ADGRF5 ^@ http://purl.uniprot.org/uniprot/G1NN99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9103:ADRB3 ^@ http://purl.uniprot.org/uniprot/P43141 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB4C sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.|||Broad tissue distribution.|||Cell membrane http://togogenome.org/gene/9103:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A803Y301|||http://purl.uniprot.org/uniprot/A0A803Y5V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9103:LOC100546675 ^@ http://purl.uniprot.org/uniprot/A0A803Y9L1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9103:CAMSAP1 ^@ http://purl.uniprot.org/uniprot/G1MVZ2 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9103:LOC104911986 ^@ http://purl.uniprot.org/uniprot/A0A803YSX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9103:MAP3K14 ^@ http://purl.uniprot.org/uniprot/G1NEI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm|||Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. http://togogenome.org/gene/9103:CGA ^@ http://purl.uniprot.org/uniprot/P68241 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. Glycoprotein hormones are heterodimers composed of a common alpha chain described here and a unique beta chain which confers their biological specificity to the different hormones.|||Secreted|||Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9103:SLC16A12 ^@ http://purl.uniprot.org/uniprot/G1N8H8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GRIK3 ^@ http://purl.uniprot.org/uniprot/G1MWR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9103:DCLRE1C ^@ http://purl.uniprot.org/uniprot/G3UPF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9103:E2F1 ^@ http://purl.uniprot.org/uniprot/G1MU18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9103:LSM5 ^@ http://purl.uniprot.org/uniprot/G1NHQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9103:PLN ^@ http://purl.uniprot.org/uniprot/A0A803XW87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9103:BID ^@ http://purl.uniprot.org/uniprot/G1NL76 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.|||Induces caspases and apoptosis. Counters the protective effect of BCL2.|||Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9103:ELL2 ^@ http://purl.uniprot.org/uniprot/G1MYB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9103:ECHDC2 ^@ http://purl.uniprot.org/uniprot/G1NFE0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9103:CPPED1 ^@ http://purl.uniprot.org/uniprot/G1MQH3 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family. http://togogenome.org/gene/9103:LOC100542475 ^@ http://purl.uniprot.org/uniprot/G1NFU9 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9103:ATF4 ^@ http://purl.uniprot.org/uniprot/G1NIF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/9103:GTF2E2 ^@ http://purl.uniprot.org/uniprot/G1N0J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9103:GNB3 ^@ http://purl.uniprot.org/uniprot/G1NMV3 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9103:BRIX1 ^@ http://purl.uniprot.org/uniprot/A0A803YQ73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9103:LOC104909322 ^@ http://purl.uniprot.org/uniprot/A0A803XLT5|||http://purl.uniprot.org/uniprot/A0A803Y2U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the elastin family.|||extracellular matrix http://togogenome.org/gene/9103:ANK1 ^@ http://purl.uniprot.org/uniprot/A0A803Y670 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9103:GRIN2B ^@ http://purl.uniprot.org/uniprot/G1NH69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9103:UGDH ^@ http://purl.uniprot.org/uniprot/G1NI62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9103:RAD21L1 ^@ http://purl.uniprot.org/uniprot/G1N7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9103:FRG1 ^@ http://purl.uniprot.org/uniprot/A0A803YA73|||http://purl.uniprot.org/uniprot/G1NG30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9103:DBX1 ^@ http://purl.uniprot.org/uniprot/G1MTT0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:RPL27 ^@ http://purl.uniprot.org/uniprot/G1MYN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9103:NONO ^@ http://purl.uniprot.org/uniprot/G1MYJ8 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9103:LOC100544708 ^@ http://purl.uniprot.org/uniprot/G1NFC3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9103:WNT5B ^@ http://purl.uniprot.org/uniprot/G1NL28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9103:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A803Y0R9|||http://purl.uniprot.org/uniprot/G1N4Q8|||http://purl.uniprot.org/uniprot/G3UUB1 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9103:SDF4 ^@ http://purl.uniprot.org/uniprot/G1MW20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Golgi apparatus lumen http://togogenome.org/gene/9103:RBP2 ^@ http://purl.uniprot.org/uniprot/G1MZ01 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9103:LOC100541189 ^@ http://purl.uniprot.org/uniprot/G1NF01 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9103:VPS72 ^@ http://purl.uniprot.org/uniprot/G1MQY4 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/9103:NFKB1 ^@ http://purl.uniprot.org/uniprot/G1NFM9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:KRT23 ^@ http://purl.uniprot.org/uniprot/G1MVN7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:VPS33A ^@ http://purl.uniprot.org/uniprot/A0A803YBI9|||http://purl.uniprot.org/uniprot/G1MZR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9103:UROS ^@ http://purl.uniprot.org/uniprot/G1NGQ3 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9103:PIGF ^@ http://purl.uniprot.org/uniprot/G1ND46 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:DCLRE1A ^@ http://purl.uniprot.org/uniprot/G1NEW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9103:CMTM4 ^@ http://purl.uniprot.org/uniprot/A0A803YQU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ATF2 ^@ http://purl.uniprot.org/uniprot/G1NBL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a dimer and can form a homodimer in the absence of DNA.|||Nucleus|||Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). http://togogenome.org/gene/9103:LOC100551038 ^@ http://purl.uniprot.org/uniprot/A0A803XWR3|||http://purl.uniprot.org/uniprot/G1NP20 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9103:VGLL2 ^@ http://purl.uniprot.org/uniprot/A0A803YQY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/9103:PRPH2 ^@ http://purl.uniprot.org/uniprot/G1NC96 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/9103:PLA2G4A ^@ http://purl.uniprot.org/uniprot/G1MRF4 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9103:LOC100546964 ^@ http://purl.uniprot.org/uniprot/G1N1K0 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9103:SESN3 ^@ http://purl.uniprot.org/uniprot/G1NQL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9103:WDR48 ^@ http://purl.uniprot.org/uniprot/G1MXU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Endosome|||Late endosome http://togogenome.org/gene/9103:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A803XVK1|||http://purl.uniprot.org/uniprot/G1NBV0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:NPY4R2 ^@ http://purl.uniprot.org/uniprot/G1NQX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/G1MRU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9103:NCF2 ^@ http://purl.uniprot.org/uniprot/A0A803XQE6 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9103:LOC104914146 ^@ http://purl.uniprot.org/uniprot/G1MV19 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:TMEM230 ^@ http://purl.uniprot.org/uniprot/G1MPV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||Vesicle|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9103:AGBL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y4P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9103:DENND10 ^@ http://purl.uniprot.org/uniprot/G1NFN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/9103:EDNRA ^@ http://purl.uniprot.org/uniprot/G1MXS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9103:LOC100545187 ^@ http://purl.uniprot.org/uniprot/G1MSI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9103:CD82 ^@ http://purl.uniprot.org/uniprot/G1NDK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9103:GGNBP2 ^@ http://purl.uniprot.org/uniprot/G1N729 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9103:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A803XKV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9103:PTPN14 ^@ http://purl.uniprot.org/uniprot/G1NBC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9103:PRF1 ^@ http://purl.uniprot.org/uniprot/G1MQE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9103:TIGD5 ^@ http://purl.uniprot.org/uniprot/G1NK45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9103:NPY5R ^@ http://purl.uniprot.org/uniprot/G3UTD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9103:ZC3H12B ^@ http://purl.uniprot.org/uniprot/G1MQ08 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9103:LOC104910743 ^@ http://purl.uniprot.org/uniprot/G1MRA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/9103:AK8 ^@ http://purl.uniprot.org/uniprot/G1N2Z2 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/9103:CSRNP1 ^@ http://purl.uniprot.org/uniprot/A0A803YL82|||http://purl.uniprot.org/uniprot/G1MXN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9103:OTUD7A ^@ http://purl.uniprot.org/uniprot/G1MZM7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:TNFRSF4 ^@ http://purl.uniprot.org/uniprot/G1MW38 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A803YQ12|||http://purl.uniprot.org/uniprot/G1N903 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9103:GSTA1.1 ^@ http://purl.uniprot.org/uniprot/C8BLR1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9103:DESI1 ^@ http://purl.uniprot.org/uniprot/G1NHS7 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9103:UBE2E3 ^@ http://purl.uniprot.org/uniprot/A0A803XR59|||http://purl.uniprot.org/uniprot/G1NAG0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:LZTFL1 ^@ http://purl.uniprot.org/uniprot/G1NGC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9103:MTMR8 ^@ http://purl.uniprot.org/uniprot/G3UQ85 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9103:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/G1N0I5 ^@ Similarity ^@ Belongs to the CCNDBP1 family. http://togogenome.org/gene/9103:NDRG1 ^@ http://purl.uniprot.org/uniprot/G1NJN8 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9103:LOC100539160 ^@ http://purl.uniprot.org/uniprot/G1N716 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9103:ENTPD6 ^@ http://purl.uniprot.org/uniprot/G1N5M2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9103:CPO ^@ http://purl.uniprot.org/uniprot/G1N8J1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9103:LOC100542077 ^@ http://purl.uniprot.org/uniprot/G1NRP6 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9103:LOC100546297 ^@ http://purl.uniprot.org/uniprot/A0A803XYI5 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9103:MITF ^@ http://purl.uniprot.org/uniprot/G1NB70|||http://purl.uniprot.org/uniprot/G3URR7|||http://purl.uniprot.org/uniprot/G3UUK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9103:MDFIC ^@ http://purl.uniprot.org/uniprot/G1N9V9 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9103:TAS1R3 ^@ http://purl.uniprot.org/uniprot/G1MVJ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:THEMIS ^@ http://purl.uniprot.org/uniprot/G1NKM7 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9103:ACY1 ^@ http://purl.uniprot.org/uniprot/G1MXL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Cytoplasm http://togogenome.org/gene/9103:CHRM2 ^@ http://purl.uniprot.org/uniprot/G1NRY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9103:PLRG1 ^@ http://purl.uniprot.org/uniprot/G1MRG5 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9103:IRAK4 ^@ http://purl.uniprot.org/uniprot/G1NB62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9103:PTCD3 ^@ http://purl.uniprot.org/uniprot/G1NKB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9103:LOC104911898 ^@ http://purl.uniprot.org/uniprot/G1MUS7 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9103:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A803YQ19 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9103:SLC20A1 ^@ http://purl.uniprot.org/uniprot/G1MX62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/9103:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A803Y7U5|||http://purl.uniprot.org/uniprot/G1N6L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9103:LOC100540763 ^@ http://purl.uniprot.org/uniprot/G1MXV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9103:TCTN2 ^@ http://purl.uniprot.org/uniprot/G1MVR2 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9103:TMEM43 ^@ http://purl.uniprot.org/uniprot/A0A803YND6|||http://purl.uniprot.org/uniprot/G1N6W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9103:LOC100539712 ^@ http://purl.uniprot.org/uniprot/G1MU70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9103:DMC1 ^@ http://purl.uniprot.org/uniprot/G1NIK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9103:AGTRAP ^@ http://purl.uniprot.org/uniprot/G1N3K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CFAP298 ^@ http://purl.uniprot.org/uniprot/G1NNV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9103:CDH5 ^@ http://purl.uniprot.org/uniprot/G1N415 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell junction|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100551422 ^@ http://purl.uniprot.org/uniprot/G1N5L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/9103:CPXM2 ^@ http://purl.uniprot.org/uniprot/G1NGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9103:CHGA ^@ http://purl.uniprot.org/uniprot/A0A803Y422 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9103:ADPRH ^@ http://purl.uniprot.org/uniprot/A0A803Y7U0 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9103:PSMA6 ^@ http://purl.uniprot.org/uniprot/G1NIQ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9103:SLC23A2 ^@ http://purl.uniprot.org/uniprot/A0A803YNX2|||http://purl.uniprot.org/uniprot/G1MPW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/9103:BDH1 ^@ http://purl.uniprot.org/uniprot/G1N528 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:TBCD ^@ http://purl.uniprot.org/uniprot/G1MX06 ^@ Similarity ^@ Belongs to the TBCD family. http://togogenome.org/gene/9103:RAD51 ^@ http://purl.uniprot.org/uniprot/G5E7T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9103:CASP10 ^@ http://purl.uniprot.org/uniprot/G1N728 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9103:APPL2 ^@ http://purl.uniprot.org/uniprot/G1NJS4 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9103:IMP4 ^@ http://purl.uniprot.org/uniprot/G1MQ28 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9103:FZR1 ^@ http://purl.uniprot.org/uniprot/G1MRR2 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9103:C17H12orf49 ^@ http://purl.uniprot.org/uniprot/G1NCB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:MAT1A ^@ http://purl.uniprot.org/uniprot/G1MQP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9103:NDUFB3 ^@ http://purl.uniprot.org/uniprot/G1N6Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ADSL ^@ http://purl.uniprot.org/uniprot/G1NIA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/9103:SGTB ^@ http://purl.uniprot.org/uniprot/A0A803XUZ1 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9103:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/A0A803YHI0 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9103:KIF20A ^@ http://purl.uniprot.org/uniprot/G1MXT8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:RHAG ^@ http://purl.uniprot.org/uniprot/G3UT38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9103:SIRT4 ^@ http://purl.uniprot.org/uniprot/G1N9J9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Mitochondrion matrix|||NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. http://togogenome.org/gene/9103:CCNK ^@ http://purl.uniprot.org/uniprot/G1NJG3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9103:CA12 ^@ http://purl.uniprot.org/uniprot/G1MY57 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9103:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A803Y898 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9103:SYF2 ^@ http://purl.uniprot.org/uniprot/G1MT43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9103:INTS11 ^@ http://purl.uniprot.org/uniprot/A0A803Y209 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.|||Nucleus http://togogenome.org/gene/9103:TUBB1 ^@ http://purl.uniprot.org/uniprot/G1N9A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9103:PIK3CD ^@ http://purl.uniprot.org/uniprot/G1MY67 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9103:HINT1 ^@ http://purl.uniprot.org/uniprot/G1N4D3 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9103:PELI1 ^@ http://purl.uniprot.org/uniprot/A0A803YEP7 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/9103:CDX4 ^@ http://purl.uniprot.org/uniprot/A0A803YB80|||http://purl.uniprot.org/uniprot/G1N2B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9103:GNRH1 ^@ http://purl.uniprot.org/uniprot/G1MQ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted http://togogenome.org/gene/9103:LOC100543781 ^@ http://purl.uniprot.org/uniprot/G1NDR1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A803Y6F9 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9103:NMT1 ^@ http://purl.uniprot.org/uniprot/G1MPW4 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9103:PUS1 ^@ http://purl.uniprot.org/uniprot/G1MSZ1 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9103:SLC30A6 ^@ http://purl.uniprot.org/uniprot/G1NFQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9103:TSHZ2 ^@ http://purl.uniprot.org/uniprot/G1NRB1 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/9103:LOC100541174 ^@ http://purl.uniprot.org/uniprot/G1NCM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:HOMER2 ^@ http://purl.uniprot.org/uniprot/G1N6W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9103:LOC100551319 ^@ http://purl.uniprot.org/uniprot/G1ND93 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:ADGRD1 ^@ http://purl.uniprot.org/uniprot/G1MTR4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/G1NK71 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9103:HESX1 ^@ http://purl.uniprot.org/uniprot/G1N3F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9103:C2H6orf58 ^@ http://purl.uniprot.org/uniprot/A0A803XPF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9103:LOC104910762 ^@ http://purl.uniprot.org/uniprot/A0A803YPM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTUS1 family.|||Nucleus http://togogenome.org/gene/9103:KCNA10 ^@ http://purl.uniprot.org/uniprot/G1NRF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A803Y547|||http://purl.uniprot.org/uniprot/G1NC88 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9103:LOC100550754 ^@ http://purl.uniprot.org/uniprot/G1N854 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9103:RTN1 ^@ http://purl.uniprot.org/uniprot/G1NLH0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:DUSP27 ^@ http://purl.uniprot.org/uniprot/G1NNP2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9103:ERAL1 ^@ http://purl.uniprot.org/uniprot/G1NJF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Membrane|||Mitochondrion inner membrane|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. http://togogenome.org/gene/9103:RYR3 ^@ http://purl.uniprot.org/uniprot/B4XW98 ^@ Subcellular Location Annotation ^@ Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9103:SYNPR ^@ http://purl.uniprot.org/uniprot/G3UPH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9103:ARPC1B ^@ http://purl.uniprot.org/uniprot/G1MYC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9103:RELL2 ^@ http://purl.uniprot.org/uniprot/G1MT62 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9103:EML1 ^@ http://purl.uniprot.org/uniprot/A0A803Y6C7 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/9103:SPSB3 ^@ http://purl.uniprot.org/uniprot/G1NBT3 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9103:DTYMK ^@ http://purl.uniprot.org/uniprot/A0A803YH47 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9103:ADTRP ^@ http://purl.uniprot.org/uniprot/A0A803XXX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9103:NPY2R ^@ http://purl.uniprot.org/uniprot/G1NS97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100126556 ^@ http://purl.uniprot.org/uniprot/A7WPR7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:KCNAB1 ^@ http://purl.uniprot.org/uniprot/G1NE35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9103:RAD54L2 ^@ http://purl.uniprot.org/uniprot/A0A803Y4T1|||http://purl.uniprot.org/uniprot/G1MVA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9103:IKBKB ^@ http://purl.uniprot.org/uniprot/G1MVF3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:IDH2 ^@ http://purl.uniprot.org/uniprot/H9H0Q1 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/9103:RIOK1 ^@ http://purl.uniprot.org/uniprot/G1MXN3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9103:SCN3B ^@ http://purl.uniprot.org/uniprot/G1MSP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9103:PDE4B ^@ http://purl.uniprot.org/uniprot/G1NH48 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9103:GHRL ^@ http://purl.uniprot.org/uniprot/Q7T1B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Secreted http://togogenome.org/gene/9103:CRYBA4 ^@ http://purl.uniprot.org/uniprot/G1N4V6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9103:B3GNT2 ^@ http://purl.uniprot.org/uniprot/G1NRV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:LOC104913409 ^@ http://purl.uniprot.org/uniprot/G1NRA5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:MST1R ^@ http://purl.uniprot.org/uniprot/G1MUY8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:ABR ^@ http://purl.uniprot.org/uniprot/G1N407 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/9103:C1R ^@ http://purl.uniprot.org/uniprot/G3UP05 ^@ Caution|||Function|||Subunit ^@ C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.|||C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:BOK ^@ http://purl.uniprot.org/uniprot/G1MWK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane http://togogenome.org/gene/9103:ME1 ^@ http://purl.uniprot.org/uniprot/G1NLV4|||http://purl.uniprot.org/uniprot/Q90XC1 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9103:FOXN1 ^@ http://purl.uniprot.org/uniprot/G1N257 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:SLC45A1 ^@ http://purl.uniprot.org/uniprot/G1MQD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:PROKR1 ^@ http://purl.uniprot.org/uniprot/G1MYX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:LRWD1 ^@ http://purl.uniprot.org/uniprot/G1MWS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/9103:SPPL2B ^@ http://purl.uniprot.org/uniprot/G1MQ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:CLCN6 ^@ http://purl.uniprot.org/uniprot/G1N3H1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:GPX3 ^@ http://purl.uniprot.org/uniprot/M1EWH6 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9103:C8A ^@ http://purl.uniprot.org/uniprot/G1NG31 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:STMN2 ^@ http://purl.uniprot.org/uniprot/G1NGF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stathmin family.|||Cytoplasm|||Membrane|||lamellipodium http://togogenome.org/gene/9103:LOC100540188 ^@ http://purl.uniprot.org/uniprot/G1NCY5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9103:KMT5B ^@ http://purl.uniprot.org/uniprot/G1NAG9 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9103:RNF111 ^@ http://purl.uniprot.org/uniprot/G1N144 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arkadia family.|||PML body http://togogenome.org/gene/9103:CCNI2 ^@ http://purl.uniprot.org/uniprot/G1NA42 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9103:TOP3B ^@ http://purl.uniprot.org/uniprot/A0A803YR67|||http://purl.uniprot.org/uniprot/G1MQQ8 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9103:NEIL3 ^@ http://purl.uniprot.org/uniprot/G1N4K2 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9103:LOC100548295 ^@ http://purl.uniprot.org/uniprot/G1N3Q5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9103:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A803XZL0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:HARS1 ^@ http://purl.uniprot.org/uniprot/G3UT80 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9103:GNG12 ^@ http://purl.uniprot.org/uniprot/G1NHD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9103:TMEM200A ^@ http://purl.uniprot.org/uniprot/G1NRT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9103:UTS2R ^@ http://purl.uniprot.org/uniprot/A0A803XYY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9103:ATP1A1 ^@ http://purl.uniprot.org/uniprot/G1NNB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/9103:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/G1N2D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9103:LOC100542185 ^@ http://purl.uniprot.org/uniprot/G1N799 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9103:PSMF1 ^@ http://purl.uniprot.org/uniprot/G1N7H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9103:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/G1NAL3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9103:CWC15 ^@ http://purl.uniprot.org/uniprot/G1NQM0 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9103:LOC100544098 ^@ http://purl.uniprot.org/uniprot/G1MVR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9103:ACSF2 ^@ http://purl.uniprot.org/uniprot/G1NA59 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9103:LANCL2 ^@ http://purl.uniprot.org/uniprot/A0A803Y6W9 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9103:CEP170 ^@ http://purl.uniprot.org/uniprot/A0A803XLY8|||http://purl.uniprot.org/uniprot/A0A803YRK7 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/9103:DHX30 ^@ http://purl.uniprot.org/uniprot/G1MRB7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/9103:BMPR1A ^@ http://purl.uniprot.org/uniprot/G3UPV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9103:PCBP4 ^@ http://purl.uniprot.org/uniprot/G1MXR3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:RCAN3 ^@ http://purl.uniprot.org/uniprot/G1N2N5 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9103:LOC100539085 ^@ http://purl.uniprot.org/uniprot/G1NMY4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:SLC1A2 ^@ http://purl.uniprot.org/uniprot/G1ND48|||http://purl.uniprot.org/uniprot/G3US00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9103:GC ^@ http://purl.uniprot.org/uniprot/G1NCF1 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9103:NFIL3 ^@ http://purl.uniprot.org/uniprot/G1NS28 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/9103:EPCAM ^@ http://purl.uniprot.org/uniprot/G1N0W4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:LOC100541180 ^@ http://purl.uniprot.org/uniprot/H9H2C4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:RNFT1 ^@ http://purl.uniprot.org/uniprot/G1N6B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:FAM163B ^@ http://purl.uniprot.org/uniprot/G1N4D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9103:ADRB1 ^@ http://purl.uniprot.org/uniprot/P07700 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity (PubMed:18594507). In dorsal pons neurons, involved in the regulation of sleep/wake behaviors (By similarity).|||Cell membrane|||Early endosome|||Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. http://togogenome.org/gene/9103:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A803XTY3|||http://purl.uniprot.org/uniprot/A0A803Y3B9|||http://purl.uniprot.org/uniprot/A0A803YFU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9103:OTOP1 ^@ http://purl.uniprot.org/uniprot/G1NJ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:RPL7L1 ^@ http://purl.uniprot.org/uniprot/G1NE29 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9103:MPC2 ^@ http://purl.uniprot.org/uniprot/G1NNN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:SHROOM1 ^@ http://purl.uniprot.org/uniprot/A0A803Y281|||http://purl.uniprot.org/uniprot/A0A803Y7U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9103:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A803YCX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SLC5A1 ^@ http://purl.uniprot.org/uniprot/G1N7T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9103:ZHX1 ^@ http://purl.uniprot.org/uniprot/G1NIY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9103:LOC100541206 ^@ http://purl.uniprot.org/uniprot/G1NQY4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:HS6ST2 ^@ http://purl.uniprot.org/uniprot/G1MVT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9103:LOC100545667 ^@ http://purl.uniprot.org/uniprot/A0A803YF57 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9103:TMEM177 ^@ http://purl.uniprot.org/uniprot/G1NRW7 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/9103:NRDE2 ^@ http://purl.uniprot.org/uniprot/A0A803YGT5 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/9103:RBX1 ^@ http://purl.uniprot.org/uniprot/G1NI60 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9103:ACAN ^@ http://purl.uniprot.org/uniprot/A0A803XTU4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9103:HIKESHI ^@ http://purl.uniprot.org/uniprot/G1NQR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9103:ARL14 ^@ http://purl.uniprot.org/uniprot/G1NS29 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9103:GANC ^@ http://purl.uniprot.org/uniprot/G1NG17 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9103:SNX20 ^@ http://purl.uniprot.org/uniprot/G1MZU5 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/9103:C5 ^@ http://purl.uniprot.org/uniprot/G1MWZ9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9103:NKAIN1 ^@ http://purl.uniprot.org/uniprot/A0A803XPI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:MYO1D ^@ http://purl.uniprot.org/uniprot/A0A803Y3F5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:SOX10 ^@ http://purl.uniprot.org/uniprot/G1NIR5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A803XZD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9103:LOC104909416 ^@ http://purl.uniprot.org/uniprot/G1NQR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9103:ASIC1 ^@ http://purl.uniprot.org/uniprot/H9H1S1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:YWHAQ ^@ http://purl.uniprot.org/uniprot/G3UUP5 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9103:MDM2 ^@ http://purl.uniprot.org/uniprot/G1NDK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9103:LOC100545163 ^@ http://purl.uniprot.org/uniprot/G1NFC6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9103:MECOM ^@ http://purl.uniprot.org/uniprot/G1ND44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PKN3 ^@ http://purl.uniprot.org/uniprot/G1MZ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/9103:TCP10L2 ^@ http://purl.uniprot.org/uniprot/A0A803YSD4 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9103:SGPL1 ^@ http://purl.uniprot.org/uniprot/G1N0U2 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9103:DGLUCY ^@ http://purl.uniprot.org/uniprot/G1NK77 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9103:SAMD8 ^@ http://purl.uniprot.org/uniprot/G1N2Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9103:DGKK ^@ http://purl.uniprot.org/uniprot/A0A803YB58|||http://purl.uniprot.org/uniprot/G1NBS3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9103:LOC100548108 ^@ http://purl.uniprot.org/uniprot/G1MSQ5 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9103:POLR3H ^@ http://purl.uniprot.org/uniprot/G1NHR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9103:LOC678666 ^@ http://purl.uniprot.org/uniprot/O93380 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9103:SPIN1 ^@ http://purl.uniprot.org/uniprot/G1MUA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/9103:PER3 ^@ http://purl.uniprot.org/uniprot/G1MQN1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:LOC100542342 ^@ http://purl.uniprot.org/uniprot/G1MUV8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:ANAPC10 ^@ http://purl.uniprot.org/uniprot/G1MX14 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9103:LOC100550646 ^@ http://purl.uniprot.org/uniprot/G1MTP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:RAF1 ^@ http://purl.uniprot.org/uniprot/A0A803XNM1|||http://purl.uniprot.org/uniprot/G1N0N1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9103:NPY ^@ http://purl.uniprot.org/uniprot/G1NDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9103:DUS3L ^@ http://purl.uniprot.org/uniprot/G1MS01 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/9103:SLC39A13 ^@ http://purl.uniprot.org/uniprot/G1NDY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:WASHC5 ^@ http://purl.uniprot.org/uniprot/G1NJ93 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9103:RAPGEF6 ^@ http://purl.uniprot.org/uniprot/A0A803XWK5|||http://purl.uniprot.org/uniprot/A0A803Y9I7|||http://purl.uniprot.org/uniprot/A0A803YN52 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/9103:ADCY3 ^@ http://purl.uniprot.org/uniprot/A0A803XN19|||http://purl.uniprot.org/uniprot/G1NMX5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9103:PTPN11 ^@ http://purl.uniprot.org/uniprot/G1N245 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9103:IL4R ^@ http://purl.uniprot.org/uniprot/G1N4R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9103:UCN3 ^@ http://purl.uniprot.org/uniprot/G1MX10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9103:LOC104909729 ^@ http://purl.uniprot.org/uniprot/A0A803XYX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/9103:LOC100543905 ^@ http://purl.uniprot.org/uniprot/G1NRI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/G3UPP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:PDCD10 ^@ http://purl.uniprot.org/uniprot/G1NDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:HHATL ^@ http://purl.uniprot.org/uniprot/G1MU11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GPN2 ^@ http://purl.uniprot.org/uniprot/G1MQA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9103:POU1F1 ^@ http://purl.uniprot.org/uniprot/Q05749 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the POU transcription factor family. Class-1 subfamily.|||Nucleus|||Pituitary gland.|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. http://togogenome.org/gene/9103:LOC100548306 ^@ http://purl.uniprot.org/uniprot/G1NA83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100539658 ^@ http://purl.uniprot.org/uniprot/G1MW70 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9103:FAM114A2 ^@ http://purl.uniprot.org/uniprot/G1N2C4 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9103:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A803Y639 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100549042 ^@ http://purl.uniprot.org/uniprot/G1NPH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9103:TNFRSF8 ^@ http://purl.uniprot.org/uniprot/G1N2W0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:NGF ^@ http://purl.uniprot.org/uniprot/G1NRG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9103:STOM ^@ http://purl.uniprot.org/uniprot/G1N774 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9103:DMRTB1 ^@ http://purl.uniprot.org/uniprot/G1NFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9103:LOC100538504 ^@ http://purl.uniprot.org/uniprot/H9H0H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:ZFYVE9 ^@ http://purl.uniprot.org/uniprot/G1NFB6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9103:TNFRSF10B ^@ http://purl.uniprot.org/uniprot/O57408 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. http://togogenome.org/gene/9103:LOC100541042 ^@ http://purl.uniprot.org/uniprot/G1NF94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:PRKCE ^@ http://purl.uniprot.org/uniprot/G1NCZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9103:SLC11A1 ^@ http://purl.uniprot.org/uniprot/G1NG58 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/9103:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/G1NL31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9103:GJC1 ^@ http://purl.uniprot.org/uniprot/G1NDG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9103:LRP6 ^@ http://purl.uniprot.org/uniprot/G1NM61 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:HVCN1 ^@ http://purl.uniprot.org/uniprot/G1N0J1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9103:LOC100538502 ^@ http://purl.uniprot.org/uniprot/G3USW3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9103:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A803YMF5 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9103:IDH1 ^@ http://purl.uniprot.org/uniprot/G1N9S1 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/9103:ICOS ^@ http://purl.uniprot.org/uniprot/G1N9B1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9103:AGAP1 ^@ http://purl.uniprot.org/uniprot/A0A803XT71|||http://purl.uniprot.org/uniprot/A0A803YK39|||http://purl.uniprot.org/uniprot/A0A803YQX3 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9103:LOC100549888 ^@ http://purl.uniprot.org/uniprot/G1NDS2 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9103:LOC100544929 ^@ http://purl.uniprot.org/uniprot/G1MQ16 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9103:LOC100550313 ^@ http://purl.uniprot.org/uniprot/G1N3Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9103:TWF2 ^@ http://purl.uniprot.org/uniprot/G1MWD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9103:LOC104913232 ^@ http://purl.uniprot.org/uniprot/G3UP54 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:LOC100542838 ^@ http://purl.uniprot.org/uniprot/G1NFH4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9103:MALL ^@ http://purl.uniprot.org/uniprot/G1MUU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:SELENOF ^@ http://purl.uniprot.org/uniprot/M9P293 ^@ Similarity ^@ Belongs to the selenoprotein M/F family. http://togogenome.org/gene/9103:GPATCH11 ^@ http://purl.uniprot.org/uniprot/G1NFA3 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9103:CALHM4 ^@ http://purl.uniprot.org/uniprot/G1NKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9103:VCP ^@ http://purl.uniprot.org/uniprot/G1MUF5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9103:LYZ ^@ http://purl.uniprot.org/uniprot/P00703 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer.|||Secreted http://togogenome.org/gene/9103:NUDT21 ^@ http://purl.uniprot.org/uniprot/G1MQK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9103:TLR5 ^@ http://purl.uniprot.org/uniprot/G1NRW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9103:SNX1 ^@ http://purl.uniprot.org/uniprot/G1MRD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9103:EPYC ^@ http://purl.uniprot.org/uniprot/G1NFI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||extracellular matrix http://togogenome.org/gene/9103:RRM1 ^@ http://purl.uniprot.org/uniprot/G1NE68 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9103:KRAS ^@ http://purl.uniprot.org/uniprot/P79800 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).|||Belongs to the small GTPase superfamily. Ras family.|||Cell membrane|||Cytoplasm|||Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). http://togogenome.org/gene/9103:ANXA10 ^@ http://purl.uniprot.org/uniprot/G1MU27 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/9103:NDOR1 ^@ http://purl.uniprot.org/uniprot/A0A803XST0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/9103:LOC100545313 ^@ http://purl.uniprot.org/uniprot/A0A803Y1N9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:KCNJ15 ^@ http://purl.uniprot.org/uniprot/A0A803YDL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9103:STK32A ^@ http://purl.uniprot.org/uniprot/A0A803YFF8|||http://purl.uniprot.org/uniprot/G1NB89 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:EAF1 ^@ http://purl.uniprot.org/uniprot/G1NFN0 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9103:ARSA ^@ http://purl.uniprot.org/uniprot/G1MU55 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9103:TMLHE ^@ http://purl.uniprot.org/uniprot/G1N0Z8 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9103:LOC100550096 ^@ http://purl.uniprot.org/uniprot/G1MQ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100540211 ^@ http://purl.uniprot.org/uniprot/G1NQ81 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/9103:GFAP ^@ http://purl.uniprot.org/uniprot/G1MPT3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/G1NKX1 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9103:EIF2A ^@ http://purl.uniprot.org/uniprot/G1NEN3 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9103:LOC100546764 ^@ http://purl.uniprot.org/uniprot/G1N4F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9103:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A803YBE5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:DYRK1A ^@ http://purl.uniprot.org/uniprot/A0A803Y3N4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9103:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A803YJ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9103:CETP ^@ http://purl.uniprot.org/uniprot/G1MVQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.|||Secreted http://togogenome.org/gene/9103:VTA1 ^@ http://purl.uniprot.org/uniprot/G1NJU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9103:CNIH3 ^@ http://purl.uniprot.org/uniprot/G1N827 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9103:EGF ^@ http://purl.uniprot.org/uniprot/G1NEX1 ^@ Caution|||Function|||Subunit ^@ EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.|||Interacts with EGFR and promotes EGFR dimerization.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:NSUN6 ^@ http://purl.uniprot.org/uniprot/G1N692 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9103:C1GALT1 ^@ http://purl.uniprot.org/uniprot/G1NBQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/9103:BCL2A1 ^@ http://purl.uniprot.org/uniprot/G1N8C5 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9103:SPTB ^@ http://purl.uniprot.org/uniprot/G1MZL4 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9103:USE1 ^@ http://purl.uniprot.org/uniprot/G1N126 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:LAMB1 ^@ http://purl.uniprot.org/uniprot/G1NC71 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9103:PROX1 ^@ http://purl.uniprot.org/uniprot/G1NBF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:GDF9 ^@ http://purl.uniprot.org/uniprot/G1NA80 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9103:NDUFB10 ^@ http://purl.uniprot.org/uniprot/G1N1W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ITGB1 ^@ http://purl.uniprot.org/uniprot/A0A803XLR5|||http://purl.uniprot.org/uniprot/G1N3E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9103:COG7 ^@ http://purl.uniprot.org/uniprot/G1N4F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:LOC100551072 ^@ http://purl.uniprot.org/uniprot/G1N9G9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:CMTR1 ^@ http://purl.uniprot.org/uniprot/G1NE56 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9103:TSHR ^@ http://purl.uniprot.org/uniprot/G1NJV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/9103:HOPX ^@ http://purl.uniprot.org/uniprot/G1N8X9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CYFIP2 ^@ http://purl.uniprot.org/uniprot/G1N0V7 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9103:KDELR3 ^@ http://purl.uniprot.org/uniprot/G1NII3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:PELO ^@ http://purl.uniprot.org/uniprot/H9H248 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.|||Nucleus http://togogenome.org/gene/9103:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/G1NN47 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9103:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/G1NKZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9103:C28H6orf89 ^@ http://purl.uniprot.org/uniprot/G5E7X0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:LOC104909628 ^@ http://purl.uniprot.org/uniprot/G1NFG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:NIF3L1 ^@ http://purl.uniprot.org/uniprot/G1N6R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9103:CD320 ^@ http://purl.uniprot.org/uniprot/A0A803XRC3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:VPS41 ^@ http://purl.uniprot.org/uniprot/G1NI09|||http://purl.uniprot.org/uniprot/G3UUD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9103:FN3K ^@ http://purl.uniprot.org/uniprot/G1MX32 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9103:CLRN3 ^@ http://purl.uniprot.org/uniprot/G1NGV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9103:SAMD4A ^@ http://purl.uniprot.org/uniprot/A0A803YCS5|||http://purl.uniprot.org/uniprot/G1NLQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/9103:CFH ^@ http://purl.uniprot.org/uniprot/A0A803Y7X4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:VPS35 ^@ http://purl.uniprot.org/uniprot/A0A803XXA0 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9103:EXTL1 ^@ http://purl.uniprot.org/uniprot/G1MUS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:CCR9 ^@ http://purl.uniprot.org/uniprot/A0A803YJ08 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:TENT5C ^@ http://purl.uniprot.org/uniprot/G1NS30 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9103:CRYGS ^@ http://purl.uniprot.org/uniprot/G1MUL4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9103:NIPAL1 ^@ http://purl.uniprot.org/uniprot/G1NHH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9103:CCND2 ^@ http://purl.uniprot.org/uniprot/G1NM89 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9103:ZCCHC8 ^@ http://purl.uniprot.org/uniprot/G1MZZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC8 family.|||nucleoplasm http://togogenome.org/gene/9103:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/G1NLS7 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9103:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A803XVF7 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9103:ETF1 ^@ http://purl.uniprot.org/uniprot/G1MRV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9103:LOC104911326 ^@ http://purl.uniprot.org/uniprot/G1MVE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9103:LOC100543750 ^@ http://purl.uniprot.org/uniprot/G1NM58 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9103:CLCN3 ^@ http://purl.uniprot.org/uniprot/G1MUE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:CNRIP1 ^@ http://purl.uniprot.org/uniprot/G1MZ32 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9103:VWC2L ^@ http://purl.uniprot.org/uniprot/A0A803Y548|||http://purl.uniprot.org/uniprot/G1MX43 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9103:CPSF3 ^@ http://purl.uniprot.org/uniprot/G1NMJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:CHMP1B ^@ http://purl.uniprot.org/uniprot/G1MSD9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9103:UCK1 ^@ http://purl.uniprot.org/uniprot/G1N2D0 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9103:SERPINB5 ^@ http://purl.uniprot.org/uniprot/G1MZQ0 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9103:HSP90B1 ^@ http://purl.uniprot.org/uniprot/G1NK19 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9103:NELL2 ^@ http://purl.uniprot.org/uniprot/G1NBC9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/A0A803Y6L2 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9103:GATA-4 ^@ http://purl.uniprot.org/uniprot/G1NN28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:PHF19 ^@ http://purl.uniprot.org/uniprot/G1MWJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9103:ND6 ^@ http://purl.uniprot.org/uniprot/F1JUN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9103:LOC100550948 ^@ http://purl.uniprot.org/uniprot/G1N705 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9103:LOC100542665 ^@ http://purl.uniprot.org/uniprot/A0A803YMB9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:CCDC85C ^@ http://purl.uniprot.org/uniprot/A0A803XSZ8|||http://purl.uniprot.org/uniprot/G1NKP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9103:EPGN ^@ http://purl.uniprot.org/uniprot/G1N5I1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:SEMA3C ^@ http://purl.uniprot.org/uniprot/G1N265 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:DRD2 ^@ http://purl.uniprot.org/uniprot/G1MYK5|||http://purl.uniprot.org/uniprot/O73810 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).|||Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with CADPS and CADPS2 (By similarity). Interacts with GPRASP1, PPP1R9B and CLIC6. Interacts with ARRB2 (By similarity). Interacts with HTR2A (By similarity). Interacts with DRD1. Interacts with KCNA2 (By similarity).|||Golgi apparatus membrane|||Membrane|||Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. http://togogenome.org/gene/9103:CALHM6 ^@ http://purl.uniprot.org/uniprot/G1NKZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9103:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A803YEW3|||http://purl.uniprot.org/uniprot/G1MRP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:DPM2 ^@ http://purl.uniprot.org/uniprot/G1MX01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9103:INSR ^@ http://purl.uniprot.org/uniprot/G1N117 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9103:MRPS21 ^@ http://purl.uniprot.org/uniprot/G1MPV9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9103:SGSM3 ^@ http://purl.uniprot.org/uniprot/G1NI77 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/9103:P2RX5 ^@ http://purl.uniprot.org/uniprot/G1N487 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9103:CD8B ^@ http://purl.uniprot.org/uniprot/A0A803YNH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:GCGR ^@ http://purl.uniprot.org/uniprot/G1N1K7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:RNF152 ^@ http://purl.uniprot.org/uniprot/G1NR26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:CDIP1 ^@ http://purl.uniprot.org/uniprot/G1NAE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9103:STOML3 ^@ http://purl.uniprot.org/uniprot/G1NQ85 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9103:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/G1NFC0 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9103:MAP2K4 ^@ http://purl.uniprot.org/uniprot/A0A803XT39 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:SYNJ2 ^@ http://purl.uniprot.org/uniprot/G1NJM1 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9103:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/A0A803YIK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9103:FBLN5 ^@ http://purl.uniprot.org/uniprot/G1NKA4 ^@ Caution|||Similarity ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:TPST2 ^@ http://purl.uniprot.org/uniprot/G1N4X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9103:MXRA8 ^@ http://purl.uniprot.org/uniprot/G1MV62 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100546803 ^@ http://purl.uniprot.org/uniprot/G1NS01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:ANO10 ^@ http://purl.uniprot.org/uniprot/A0A803XRT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:BCO1 ^@ http://purl.uniprot.org/uniprot/G1N4S4 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9103:TMPRSS13 ^@ http://purl.uniprot.org/uniprot/G1MXD5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/G1MV56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:GDPD2 ^@ http://purl.uniprot.org/uniprot/G1MU66 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9103:KCNB2 ^@ http://purl.uniprot.org/uniprot/G1NG35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:DIMT1 ^@ http://purl.uniprot.org/uniprot/G1MYT1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9103:UBA3 ^@ http://purl.uniprot.org/uniprot/G1NB02 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/9103:UBE2R2 ^@ http://purl.uniprot.org/uniprot/G1MSS2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:PPARA ^@ http://purl.uniprot.org/uniprot/G3UPT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9103:LOC100540306 ^@ http://purl.uniprot.org/uniprot/A0A803YR41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9103:PDGFRB ^@ http://purl.uniprot.org/uniprot/G1N4V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane http://togogenome.org/gene/9103:LOC109363685 ^@ http://purl.uniprot.org/uniprot/G3US71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/9103:TEKT2 ^@ http://purl.uniprot.org/uniprot/G1MXD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/9103:LOC104910030 ^@ http://purl.uniprot.org/uniprot/G3X8P0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9103:GNG2 ^@ http://purl.uniprot.org/uniprot/G1NLZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9103:LOC100545013 ^@ http://purl.uniprot.org/uniprot/G1NEY8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9103:ATP2A2 ^@ http://purl.uniprot.org/uniprot/G1MXU8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9103:RBP4 ^@ http://purl.uniprot.org/uniprot/G3URC8 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9103:VWA1 ^@ http://purl.uniprot.org/uniprot/A0A803YCU2 ^@ Subcellular Location Annotation ^@ Membrane|||basement membrane http://togogenome.org/gene/9103:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A803Y3E8|||http://purl.uniprot.org/uniprot/G1N184 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9103:CDC42 ^@ http://purl.uniprot.org/uniprot/G1N4S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9103:NAB1 ^@ http://purl.uniprot.org/uniprot/G1N3F7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9103:MSL3 ^@ http://purl.uniprot.org/uniprot/G1NPD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:POMGNT2 ^@ http://purl.uniprot.org/uniprot/G1NS50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9103:BROX ^@ http://purl.uniprot.org/uniprot/G1N9P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BROX family.|||Membrane http://togogenome.org/gene/9103:SMG1 ^@ http://purl.uniprot.org/uniprot/G1N769 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9103:NR2C1 ^@ http://purl.uniprot.org/uniprot/A0A803YP82|||http://purl.uniprot.org/uniprot/G1NFV2|||http://purl.uniprot.org/uniprot/G3UR79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9103:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A803YGV3|||http://purl.uniprot.org/uniprot/G1NL77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9103:IMPA2 ^@ http://purl.uniprot.org/uniprot/G1N9L6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9103:HPD ^@ http://purl.uniprot.org/uniprot/G1MZ77 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9103:ZWILCH ^@ http://purl.uniprot.org/uniprot/G1NBY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9103:PRRX2 ^@ http://purl.uniprot.org/uniprot/G1N0E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9103:TNFSF8 ^@ http://purl.uniprot.org/uniprot/G3UUJ3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9103:L3MBTL1 ^@ http://purl.uniprot.org/uniprot/G1MQ87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:ADAM17 ^@ http://purl.uniprot.org/uniprot/G1NMJ9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:VIPR2 ^@ http://purl.uniprot.org/uniprot/G1N143 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:C1H11orf54 ^@ http://purl.uniprot.org/uniprot/G1NQN3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9103:PDYN ^@ http://purl.uniprot.org/uniprot/G1N556 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opiod activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9103:CHST13 ^@ http://purl.uniprot.org/uniprot/A0A803Y5L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9103:LETM2 ^@ http://purl.uniprot.org/uniprot/G1MT37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LIPC ^@ http://purl.uniprot.org/uniprot/G1N1J3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:BYSL ^@ http://purl.uniprot.org/uniprot/A0A803XXY3 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9103:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A803YG56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9103:KCNH5 ^@ http://purl.uniprot.org/uniprot/G1NLD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CDK18 ^@ http://purl.uniprot.org/uniprot/A0A803YPT8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:IMPA1 ^@ http://purl.uniprot.org/uniprot/G1NGK8 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9103:EIF2B5 ^@ http://purl.uniprot.org/uniprot/G1N9P1 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/9103:ATP7B ^@ http://purl.uniprot.org/uniprot/A0A803YPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:NDUFS6 ^@ http://purl.uniprot.org/uniprot/G1N5Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:DYNLT1 ^@ http://purl.uniprot.org/uniprot/G1NJP7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9103:FGFR1 ^@ http://purl.uniprot.org/uniprot/A0A803YD22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cytoplasmic vesicle|||Membrane|||Nucleus|||Vesicle|||cytosol http://togogenome.org/gene/9103:POLR2H ^@ http://purl.uniprot.org/uniprot/A0A803XTV4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9103:GINS4 ^@ http://purl.uniprot.org/uniprot/G1MTN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9103:CLEC16A ^@ http://purl.uniprot.org/uniprot/G1N8C6 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9103:LOC104910021 ^@ http://purl.uniprot.org/uniprot/A0A803XM39 ^@ Similarity ^@ Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily. http://togogenome.org/gene/9103:NT5C3B ^@ http://purl.uniprot.org/uniprot/G1N599 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9103:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A803YBM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9103:CPNE8 ^@ http://purl.uniprot.org/uniprot/G1N690 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9103:SULT1C4 ^@ http://purl.uniprot.org/uniprot/G1NPP7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9103:PRPF38A ^@ http://purl.uniprot.org/uniprot/G1NFA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9103:LOC100541755 ^@ http://purl.uniprot.org/uniprot/A0A803Y8Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction|||axon|||cytoskeleton http://togogenome.org/gene/9103:STING1 ^@ http://purl.uniprot.org/uniprot/A0A803YGD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9103:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A803Y857 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9103:COPS7B ^@ http://purl.uniprot.org/uniprot/G1N7Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CYP3A37 ^@ http://purl.uniprot.org/uniprot/Q1PCR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9103:SLC10A2 ^@ http://purl.uniprot.org/uniprot/G1NPU0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane|||Monomer and homodimer. http://togogenome.org/gene/9103:GNGT2 ^@ http://purl.uniprot.org/uniprot/A0A803XKJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9103:SDR16C5 ^@ http://purl.uniprot.org/uniprot/G1NEV1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9103:WSCD1 ^@ http://purl.uniprot.org/uniprot/G1N952 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Membrane http://togogenome.org/gene/9103:TSEN54 ^@ http://purl.uniprot.org/uniprot/G1NB99 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/9103:NT5DC2 ^@ http://purl.uniprot.org/uniprot/G1MQG2 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9103:LOC100545745 ^@ http://purl.uniprot.org/uniprot/A0A803XSG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ALX1 ^@ http://purl.uniprot.org/uniprot/G1NF54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9103:SFRP5 ^@ http://purl.uniprot.org/uniprot/G1NBK0 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PPP6C ^@ http://purl.uniprot.org/uniprot/G1N8P5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9103:CTSS ^@ http://purl.uniprot.org/uniprot/G1MQG9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9103:LOC100549019 ^@ http://purl.uniprot.org/uniprot/A0A803YK26 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9103:MYH9 ^@ http://purl.uniprot.org/uniprot/G1NJB2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9103:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A803YDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9103:LOC100539172 ^@ http://purl.uniprot.org/uniprot/G1MQ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9103:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/G1N620 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9103:LOC100550621 ^@ http://purl.uniprot.org/uniprot/G1N6H7 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9103:LOC104913875 ^@ http://purl.uniprot.org/uniprot/G1MT64 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9103:LOC100303663 ^@ http://purl.uniprot.org/uniprot/Q90X50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9103:CAV3 ^@ http://purl.uniprot.org/uniprot/G1NCJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola|||sarcolemma http://togogenome.org/gene/9103:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/G1NIQ9|||http://purl.uniprot.org/uniprot/G3UUH8 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:PTGER4 ^@ http://purl.uniprot.org/uniprot/G1NR11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9103:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A803XW74 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9103:CCDC181 ^@ http://purl.uniprot.org/uniprot/G1NNF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/9103:LOC100543282 ^@ http://purl.uniprot.org/uniprot/G1NRI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9103:KCNMA1 ^@ http://purl.uniprot.org/uniprot/G3UQI3|||http://purl.uniprot.org/uniprot/G3UT82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9103:LOC100549160 ^@ http://purl.uniprot.org/uniprot/G1NFZ4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:LOC100546568 ^@ http://purl.uniprot.org/uniprot/A0A803YCB7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:NIT2 ^@ http://purl.uniprot.org/uniprot/G1NNH2 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9103:FAM122B ^@ http://purl.uniprot.org/uniprot/G1MW93 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9103:RPL30 ^@ http://purl.uniprot.org/uniprot/G1NHU3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9103:SELENOK ^@ http://purl.uniprot.org/uniprot/L7Q485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein K family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9103:CAPZA2 ^@ http://purl.uniprot.org/uniprot/G1N9Q5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9103:ADORA2B ^@ http://purl.uniprot.org/uniprot/G1N3G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9103:GDNF ^@ http://purl.uniprot.org/uniprot/G1MWC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9103:MVD ^@ http://purl.uniprot.org/uniprot/A0A803YBL7 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/9103:LHFPL6 ^@ http://purl.uniprot.org/uniprot/A0A803YRA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:ARAP2 ^@ http://purl.uniprot.org/uniprot/A0A803Y6M9|||http://purl.uniprot.org/uniprot/G1NIF5|||http://purl.uniprot.org/uniprot/G3URL4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:SLC16A14 ^@ http://purl.uniprot.org/uniprot/G1N2V9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CD79B ^@ http://purl.uniprot.org/uniprot/G3UV51 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:HARBI1 ^@ http://purl.uniprot.org/uniprot/G1NES5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9103:ZP1 ^@ http://purl.uniprot.org/uniprot/Q25BN0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:TK1 ^@ http://purl.uniprot.org/uniprot/G1N281 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9103:PFN3 ^@ http://purl.uniprot.org/uniprot/G1NRW9 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9103:C7H2orf76 ^@ http://purl.uniprot.org/uniprot/G1NI92 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9103:PSMB4 ^@ http://purl.uniprot.org/uniprot/G1MR75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9103:FAM72A ^@ http://purl.uniprot.org/uniprot/G1MWK5 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9103:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A803XS76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/9103:HOXB1 ^@ http://purl.uniprot.org/uniprot/H9H0F2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:NDP ^@ http://purl.uniprot.org/uniprot/G1NP39 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9103:BZW1 ^@ http://purl.uniprot.org/uniprot/G1N6K0 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9103:GTF2E1 ^@ http://purl.uniprot.org/uniprot/G1NN89 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9103:LOC100548266 ^@ http://purl.uniprot.org/uniprot/G1NAI7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9103:GATA3 ^@ http://purl.uniprot.org/uniprot/G1MZ75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:EXOSC2 ^@ http://purl.uniprot.org/uniprot/G1N1J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9103:LTN1 ^@ http://purl.uniprot.org/uniprot/G1NNU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/9103:HAUS1 ^@ http://purl.uniprot.org/uniprot/G1MS16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9103:CNDP1 ^@ http://purl.uniprot.org/uniprot/G1N7V9 ^@ Cofactor ^@ Binds 2 manganese ions per subunit. http://togogenome.org/gene/9103:OSBPL3 ^@ http://purl.uniprot.org/uniprot/G1NDS6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9103:ACO1 ^@ http://purl.uniprot.org/uniprot/G1N9K9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.|||cytosol http://togogenome.org/gene/9103:NDUFS1 ^@ http://purl.uniprot.org/uniprot/G1N8Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9103:ND3 ^@ http://purl.uniprot.org/uniprot/A9XBE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9103:EXTL2 ^@ http://purl.uniprot.org/uniprot/G1N4T8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9103:TAT ^@ http://purl.uniprot.org/uniprot/G1N9W7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9103:FAM83B ^@ http://purl.uniprot.org/uniprot/G1NMB5 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9103:PACSIN1 ^@ http://purl.uniprot.org/uniprot/H9H0G2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9103:LOC100549708 ^@ http://purl.uniprot.org/uniprot/G1NHE5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9103:EED ^@ http://purl.uniprot.org/uniprot/G1NQR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ESC family.|||Nucleus http://togogenome.org/gene/9103:CCNB3 ^@ http://purl.uniprot.org/uniprot/G1NBT7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9103:MED21 ^@ http://purl.uniprot.org/uniprot/G1NLS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9103:SSX2IP ^@ http://purl.uniprot.org/uniprot/G1NA44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9103:AGT ^@ http://purl.uniprot.org/uniprot/G1NHN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9103:SLC66A1 ^@ http://purl.uniprot.org/uniprot/G1N1D6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:MMAA ^@ http://purl.uniprot.org/uniprot/G1MXD1 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9103:HMGCS2 ^@ http://purl.uniprot.org/uniprot/G1MZD6 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9103:TMEM9 ^@ http://purl.uniprot.org/uniprot/G1MT73 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9103:MMP11 ^@ http://purl.uniprot.org/uniprot/G1N605 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9103:LOC100550690 ^@ http://purl.uniprot.org/uniprot/A0A803Y2U0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9103:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/G1NI96 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9103:SCMH1 ^@ http://purl.uniprot.org/uniprot/A0A803Y777|||http://purl.uniprot.org/uniprot/G1MQF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9103:ARHGEF18 ^@ http://purl.uniprot.org/uniprot/G1N0Q9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:NDE1 ^@ http://purl.uniprot.org/uniprot/G1N592 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/9103:ANKLE2 ^@ http://purl.uniprot.org/uniprot/G3UP66 ^@ Similarity ^@ Belongs to the ANKLE2 family. http://togogenome.org/gene/9103:FAM171A1 ^@ http://purl.uniprot.org/uniprot/G1N7B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/9103:TCTN1 ^@ http://purl.uniprot.org/uniprot/G1N0H8 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9103:LOC100546539 ^@ http://purl.uniprot.org/uniprot/G1NLC5 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9103:LOC104914649 ^@ http://purl.uniprot.org/uniprot/A0A803XZL6|||http://purl.uniprot.org/uniprot/G1MRR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Nucleus http://togogenome.org/gene/9103:MAPK6 ^@ http://purl.uniprot.org/uniprot/G1N3Q6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9103:TMEM161B ^@ http://purl.uniprot.org/uniprot/A0A803Y4F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9103:SUMF2 ^@ http://purl.uniprot.org/uniprot/A0A803Y9Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9103:INHBB ^@ http://purl.uniprot.org/uniprot/G1MX92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9103:DGKD ^@ http://purl.uniprot.org/uniprot/G1MS39 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9103:LAMB3 ^@ http://purl.uniprot.org/uniprot/G1MYW0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:MIEF1 ^@ http://purl.uniprot.org/uniprot/G1NIF1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9103:ALKAL2 ^@ http://purl.uniprot.org/uniprot/G1NMG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9103:DIS3L ^@ http://purl.uniprot.org/uniprot/G1NBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNR ribonuclease family.|||Cytoplasm http://togogenome.org/gene/9103:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A803Y2W7|||http://purl.uniprot.org/uniprot/G1NQL4 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9103:PLSCR1 ^@ http://purl.uniprot.org/uniprot/G1N4E3 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9103:ITPRIP ^@ http://purl.uniprot.org/uniprot/G1NQY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Cell membrane|||Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9103:LOC100549241 ^@ http://purl.uniprot.org/uniprot/G1MZ80 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9103:WSCD2 ^@ http://purl.uniprot.org/uniprot/G3URH6 ^@ Similarity ^@ Belongs to the WSCD family. http://togogenome.org/gene/9103:LOC100545797 ^@ http://purl.uniprot.org/uniprot/G1NFC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9103:LIG3 ^@ http://purl.uniprot.org/uniprot/G1MY77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9103:TYRO3 ^@ http://purl.uniprot.org/uniprot/G1NFK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9103:XPOT ^@ http://purl.uniprot.org/uniprot/G1NCT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9103:COX1 ^@ http://purl.uniprot.org/uniprot/A9XBE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9103:LOC100546874 ^@ http://purl.uniprot.org/uniprot/G1MSK9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9103:LOC100549117 ^@ http://purl.uniprot.org/uniprot/A0A803XNK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9103:EIF4E1B ^@ http://purl.uniprot.org/uniprot/A0A803Y0X3 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9103:SLC5A8 ^@ http://purl.uniprot.org/uniprot/G1NGQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9103:PLPBP ^@ http://purl.uniprot.org/uniprot/G1MSU6 ^@ Caution|||Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9103:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/G1N887 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9103:TSC22D2 ^@ http://purl.uniprot.org/uniprot/A0A803YCQ9|||http://purl.uniprot.org/uniprot/G1NEP1 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9103:MMD2 ^@ http://purl.uniprot.org/uniprot/A0A803Y087 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9103:LOC100303673 ^@ http://purl.uniprot.org/uniprot/Q6J9X5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9103:IL1RL1 ^@ http://purl.uniprot.org/uniprot/G1NPM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/9103:LOC100540835 ^@ http://purl.uniprot.org/uniprot/G1NLM4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:LOC100542671 ^@ http://purl.uniprot.org/uniprot/G1NPD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/9103:MLLT11 ^@ http://purl.uniprot.org/uniprot/A0A803YIQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/9103:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/G1NPR5 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9103:TMEM39B ^@ http://purl.uniprot.org/uniprot/G1MZI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9103:MATK ^@ http://purl.uniprot.org/uniprot/G1MQF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9103:CASQ2 ^@ http://purl.uniprot.org/uniprot/G1NNB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9103:LOC100540823 ^@ http://purl.uniprot.org/uniprot/G1NH25 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9103:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/A0A803Y8I2|||http://purl.uniprot.org/uniprot/G1N9U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9103:NUMB ^@ http://purl.uniprot.org/uniprot/A0A803YGD4|||http://purl.uniprot.org/uniprot/A0A803YP34|||http://purl.uniprot.org/uniprot/G1NGK6|||http://purl.uniprot.org/uniprot/G1NGL4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9103:NMUR2 ^@ http://purl.uniprot.org/uniprot/G1N2N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9103:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A803Y9V3 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9103:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A803XZ57|||http://purl.uniprot.org/uniprot/G1NGP2 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9103:YIPF5 ^@ http://purl.uniprot.org/uniprot/G1NAT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9103:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A803XLU7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9103:STOML1 ^@ http://purl.uniprot.org/uniprot/G1MVN0 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9103:GOLGA5 ^@ http://purl.uniprot.org/uniprot/G1NKD1 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.|||Membrane http://togogenome.org/gene/9103:KCNK3 ^@ http://purl.uniprot.org/uniprot/G3UQ81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9103:SSR3 ^@ http://purl.uniprot.org/uniprot/G1NE14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9103:LOC100547060 ^@ http://purl.uniprot.org/uniprot/G1NAU2 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9103:LSM1 ^@ http://purl.uniprot.org/uniprot/G1MTD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||LSm subunits form a heteromer with a donut shape.|||P-body|||Probably involved with other LSm subunits in the general process of degradation of mRNAs. http://togogenome.org/gene/9103:LOC104911865 ^@ http://purl.uniprot.org/uniprot/A0A803Y2J7|||http://purl.uniprot.org/uniprot/G1N2G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane http://togogenome.org/gene/9103:LOC100550389 ^@ http://purl.uniprot.org/uniprot/G1NG37 ^@ Similarity ^@ Belongs to the TFIIE alpha subunit family. http://togogenome.org/gene/9103:CLPS ^@ http://purl.uniprot.org/uniprot/G1MPW1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9103:PRSS12 ^@ http://purl.uniprot.org/uniprot/G1NEC9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:CDH18 ^@ http://purl.uniprot.org/uniprot/A0A803Y166|||http://purl.uniprot.org/uniprot/G1N1R6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:SEC13 ^@ http://purl.uniprot.org/uniprot/G1NCU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane|||nuclear pore complex http://togogenome.org/gene/9103:AURKA ^@ http://purl.uniprot.org/uniprot/G1NAG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9103:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A803Y9Z4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9103:WNT6 ^@ http://purl.uniprot.org/uniprot/G1NFU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9103:CSNK1D ^@ http://purl.uniprot.org/uniprot/A0A803YS01|||http://purl.uniprot.org/uniprot/G1N1Q3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9103:SRPX ^@ http://purl.uniprot.org/uniprot/G1NP52 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/H9H1M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9103:MINAR1 ^@ http://purl.uniprot.org/uniprot/A0A803YLM7|||http://purl.uniprot.org/uniprot/G1N8E1 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9103:MFSD11 ^@ http://purl.uniprot.org/uniprot/G1MY42|||http://purl.uniprot.org/uniprot/G3UTK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9103:AMOTL2 ^@ http://purl.uniprot.org/uniprot/G1MVB8 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9103:DRD1 ^@ http://purl.uniprot.org/uniprot/G1NR41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:DNAAF4 ^@ http://purl.uniprot.org/uniprot/G1N2N7 ^@ Subcellular Location Annotation ^@ Dynein axonemal particle|||neuron projection http://togogenome.org/gene/9103:COL4A2 ^@ http://purl.uniprot.org/uniprot/G1NPT0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9103:BCL9L ^@ http://purl.uniprot.org/uniprot/G1MYB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9103:BTG4 ^@ http://purl.uniprot.org/uniprot/G1MXG8 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9103:MCM8 ^@ http://purl.uniprot.org/uniprot/G1N6W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/9103:LOC100539130 ^@ http://purl.uniprot.org/uniprot/G1NPK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 23 family.|||Secreted http://togogenome.org/gene/9103:RMI1 ^@ http://purl.uniprot.org/uniprot/G1NS22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9103:EIF2S1 ^@ http://purl.uniprot.org/uniprot/G1NHC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9103:RNF2 ^@ http://purl.uniprot.org/uniprot/A0A803XRQ0|||http://purl.uniprot.org/uniprot/G1MRK5 ^@ Subcellular Location Annotation ^@ Chromosome|||Cytoplasm http://togogenome.org/gene/9103:PDGFRL ^@ http://purl.uniprot.org/uniprot/G1NGA0 ^@ Subcellular Location Annotation|||Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2.|||Secreted http://togogenome.org/gene/9103:TAAR2 ^@ http://purl.uniprot.org/uniprot/G1NRS9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9103:LOC100546335 ^@ http://purl.uniprot.org/uniprot/G1NE71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC104909200 ^@ http://purl.uniprot.org/uniprot/G1MQS3|||http://purl.uniprot.org/uniprot/G1MSP2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9103:LGMN ^@ http://purl.uniprot.org/uniprot/A0A803YI36 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9103:EMC3 ^@ http://purl.uniprot.org/uniprot/G1MU78 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9103:MAFG ^@ http://purl.uniprot.org/uniprot/A0A803YD60 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9103:KBTBD8 ^@ http://purl.uniprot.org/uniprot/A0A803YBW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9103:NCBP2 ^@ http://purl.uniprot.org/uniprot/A0A803YQT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9103:HIF1A ^@ http://purl.uniprot.org/uniprot/A0A803XM52 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:CASP2 ^@ http://purl.uniprot.org/uniprot/G1MZ40 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9103:SERPINE2 ^@ http://purl.uniprot.org/uniprot/G3URX3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9103:LOC100548822 ^@ http://purl.uniprot.org/uniprot/G1MYC2 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9103:MCTP2 ^@ http://purl.uniprot.org/uniprot/G1NA76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:CKMT2 ^@ http://purl.uniprot.org/uniprot/G1N717 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9103:LOC100546656 ^@ http://purl.uniprot.org/uniprot/A0A803YMR2 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9103:NDST2 ^@ http://purl.uniprot.org/uniprot/G1N3Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9103:LOC100541400 ^@ http://purl.uniprot.org/uniprot/G1NH22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:IDH3A ^@ http://purl.uniprot.org/uniprot/A0A803XK05|||http://purl.uniprot.org/uniprot/G1MXP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9103:THYN1 ^@ http://purl.uniprot.org/uniprot/G1MS60 ^@ Function ^@ Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9103:RPA2 ^@ http://purl.uniprot.org/uniprot/G1MQZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/9103:HOMER3 ^@ http://purl.uniprot.org/uniprot/G1MZE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9103:LOC100547437 ^@ http://purl.uniprot.org/uniprot/G1N2B2 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/9103:SERINC1 ^@ http://purl.uniprot.org/uniprot/G1NKT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9103:UBE2D1 ^@ http://purl.uniprot.org/uniprot/G1MRH5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9103:MRPL22 ^@ http://purl.uniprot.org/uniprot/G1N1U9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9103:LSM8 ^@ http://purl.uniprot.org/uniprot/G1N9G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9103:LOC100541214 ^@ http://purl.uniprot.org/uniprot/G1N6T5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9103:KCTD10 ^@ http://purl.uniprot.org/uniprot/G1N3E4 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9103:TAF9B ^@ http://purl.uniprot.org/uniprot/G1MS53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9103:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/G1N7W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.|||Nucleus http://togogenome.org/gene/9103:SPPL2A ^@ http://purl.uniprot.org/uniprot/G3UTY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9103:SLC2A1 ^@ http://purl.uniprot.org/uniprot/G1N5E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9103:DDX49 ^@ http://purl.uniprot.org/uniprot/G3URB9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9103:TXNL4A ^@ http://purl.uniprot.org/uniprot/G1MTF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9103:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A803XN89 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9103:RPS3A ^@ http://purl.uniprot.org/uniprot/G1MYH2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/9103:TMEM198 ^@ http://purl.uniprot.org/uniprot/G1NFF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9103:KCNJ8 ^@ http://purl.uniprot.org/uniprot/G1NLM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9103:LOC100540365 ^@ http://purl.uniprot.org/uniprot/G1NP40 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9103:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A803YBW0|||http://purl.uniprot.org/uniprot/G1MUR5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9103:SH3BGRL3 ^@ http://purl.uniprot.org/uniprot/A0A803YAI4 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9103:LPAR3 ^@ http://purl.uniprot.org/uniprot/G1NA00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:GNL2 ^@ http://purl.uniprot.org/uniprot/G1MW94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9103:SMCO4 ^@ http://purl.uniprot.org/uniprot/A0A803Y664 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMCO4 family.|||Membrane http://togogenome.org/gene/9103:SPAM1 ^@ http://purl.uniprot.org/uniprot/G1N8A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9103:LOC100546233 ^@ http://purl.uniprot.org/uniprot/G1NLN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9103:PKP1 ^@ http://purl.uniprot.org/uniprot/G1MT53 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9103:IFT20 ^@ http://purl.uniprot.org/uniprot/G1N8U6 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9103:LOC100550520 ^@ http://purl.uniprot.org/uniprot/H9H1I8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9103:EBAG9 ^@ http://purl.uniprot.org/uniprot/G1NII8 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9103:AZIN2 ^@ http://purl.uniprot.org/uniprot/G1N0D8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9103:RGS5 ^@ http://purl.uniprot.org/uniprot/G5E7W9 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9103:ASCC1 ^@ http://purl.uniprot.org/uniprot/G1N1E0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9103:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A803YG99|||http://purl.uniprot.org/uniprot/A0A803YJQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9103:LOC100548490 ^@ http://purl.uniprot.org/uniprot/A0A803XZA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9103:LZIC ^@ http://purl.uniprot.org/uniprot/G1MY71 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9103:DDOST ^@ http://purl.uniprot.org/uniprot/G1N6F6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/9103:LEO1 ^@ http://purl.uniprot.org/uniprot/G1N3S2 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/9103:RPA1 ^@ http://purl.uniprot.org/uniprot/G1N189 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/9103:CA4 ^@ http://purl.uniprot.org/uniprot/A0A803Y7B7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-carbonic anhydrase family.|||Cell membrane|||Interacts with SLC4A4.|||Membrane http://togogenome.org/gene/9103:NRG3 ^@ http://purl.uniprot.org/uniprot/G1MQD5 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.