http://togogenome.org/gene/869210:MARKY_RS04235 ^@ http://purl.uniprot.org/uniprot/F2NNZ5 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/869210:MARKY_RS00880 ^@ http://purl.uniprot.org/uniprot/F2NN91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS10685 ^@ http://purl.uniprot.org/uniprot/F2NPS2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS07280 ^@ http://purl.uniprot.org/uniprot/F2NML2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS10730 ^@ http://purl.uniprot.org/uniprot/F2NPS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS06045 ^@ http://purl.uniprot.org/uniprot/F2NQK9 ^@ Function|||Similarity ^@ Belongs to the RlpA family.|||Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. http://togogenome.org/gene/869210:MARKY_RS01490 ^@ http://purl.uniprot.org/uniprot/F2NNN3 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/869210:MARKY_RS01870 ^@ http://purl.uniprot.org/uniprot/F2NQ20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS10245 ^@ http://purl.uniprot.org/uniprot/F2NN25 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/869210:MARKY_RS08245 ^@ http://purl.uniprot.org/uniprot/F2NKC5 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/869210:MARKY_RS01360 ^@ http://purl.uniprot.org/uniprot/F2NNL0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/869210:MARKY_RS04880 ^@ http://purl.uniprot.org/uniprot/F2NL98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS00730 ^@ http://purl.uniprot.org/uniprot/F2NLS1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.|||This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. http://togogenome.org/gene/869210:MARKY_RS06150 ^@ http://purl.uniprot.org/uniprot/F2NQN0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/869210:MARKY_RS05810 ^@ http://purl.uniprot.org/uniprot/F2NPA1 ^@ Caution|||Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/869210:MARKY_RS10155 ^@ http://purl.uniprot.org/uniprot/F2NN08 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/869210:MARKY_RS02015 ^@ http://purl.uniprot.org/uniprot/F2NKW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/869210:MARKY_RS02735 ^@ http://purl.uniprot.org/uniprot/F2NNR2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/869210:MARKY_RS05445 ^@ http://purl.uniprot.org/uniprot/F2NME2 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/869210:MARKY_RS09350 ^@ http://purl.uniprot.org/uniprot/F2NR15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/869210:MARKY_RS04150 ^@ http://purl.uniprot.org/uniprot/F2NNX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/869210:MARKY_RS01465 ^@ http://purl.uniprot.org/uniprot/F2NNM8 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/869210:MARKY_RS03035 ^@ http://purl.uniprot.org/uniprot/F2NQ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS01095 ^@ http://purl.uniprot.org/uniprot/F2NND2 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/869210:MARKY_RS02555 ^@ http://purl.uniprot.org/uniprot/F2NLZ4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/869210:MARKY_RS09300 ^@ http://purl.uniprot.org/uniprot/F2NR05 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/869210:MARKY_RS00365 ^@ http://purl.uniprot.org/uniprot/F2NKR7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS00690 ^@ http://purl.uniprot.org/uniprot/F2NLR4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/869210:MARKY_RS09480 ^@ http://purl.uniprot.org/uniprot/F2NR41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS08605 ^@ http://purl.uniprot.org/uniprot/F2NMR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/869210:MARKY_RS03610 ^@ http://purl.uniprot.org/uniprot/F2NL57 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/869210:MARKY_RS01400 ^@ http://purl.uniprot.org/uniprot/F2NNL8 ^@ Similarity ^@ Belongs to the UbiD family. http://togogenome.org/gene/869210:MARKY_RS03365 ^@ http://purl.uniprot.org/uniprot/F2NQ99 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02480 ^@ http://purl.uniprot.org/uniprot/F2NLX9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS06915 ^@ http://purl.uniprot.org/uniprot/F2NLL2 ^@ Similarity ^@ Belongs to the ycf81 family. http://togogenome.org/gene/869210:MARKY_RS06345 ^@ http://purl.uniprot.org/uniprot/F2NK36 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS07970 ^@ http://purl.uniprot.org/uniprot/F2NQV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS01130 ^@ http://purl.uniprot.org/uniprot/F2NND9 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS03025 ^@ http://purl.uniprot.org/uniprot/F2NNW9 ^@ Function|||Similarity ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane. http://togogenome.org/gene/869210:MARKY_RS02640 ^@ http://purl.uniprot.org/uniprot/F2NM11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS04885 ^@ http://purl.uniprot.org/uniprot/F2NL99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0316 family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS05000 ^@ http://purl.uniprot.org/uniprot/F2NLC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/869210:MARKY_RS08585 ^@ http://purl.uniprot.org/uniprot/F2NMQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS10820 ^@ http://purl.uniprot.org/uniprot/F2NPU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS05305 ^@ http://purl.uniprot.org/uniprot/F2NMB2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/869210:MARKY_RS01475 ^@ http://purl.uniprot.org/uniprot/F2NNN0 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/869210:MARKY_RS03945 ^@ http://purl.uniprot.org/uniprot/F2NM57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS10760 ^@ http://purl.uniprot.org/uniprot/F2NPT5 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/869210:MARKY_RS05780 ^@ http://purl.uniprot.org/uniprot/F2NP95 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS08280 ^@ http://purl.uniprot.org/uniprot/F2NKD2 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/869210:MARKY_RS05720 ^@ http://purl.uniprot.org/uniprot/F2NP84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS11165 ^@ http://purl.uniprot.org/uniprot/F2NR91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS07815 ^@ http://purl.uniprot.org/uniprot/F2NQS2 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/869210:MARKY_RS00865 ^@ http://purl.uniprot.org/uniprot/F2NN88 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/869210:MARKY_RS06530 ^@ http://purl.uniprot.org/uniprot/F2NK70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08160 ^@ http://purl.uniprot.org/uniprot/F2NKA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/869210:MARKY_RS02590 ^@ http://purl.uniprot.org/uniprot/F2NM01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 30 kDa subunit family.|||Cell inner membrane|||NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/869210:MARKY_RS02535 ^@ http://purl.uniprot.org/uniprot/F2NLZ0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/869210:MARKY_RS04320 ^@ http://purl.uniprot.org/uniprot/F2NP13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS01405 ^@ http://purl.uniprot.org/uniprot/F2NNL9 ^@ Similarity ^@ Belongs to the CFA/CMAS family. http://togogenome.org/gene/869210:MARKY_RS01835 ^@ http://purl.uniprot.org/uniprot/F2NQ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS10665 ^@ http://purl.uniprot.org/uniprot/F2NPR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS05475 ^@ http://purl.uniprot.org/uniprot/F2NME8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS08065 ^@ http://purl.uniprot.org/uniprot/F2NK89 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/869210:MARKY_RS02615 ^@ http://purl.uniprot.org/uniprot/F2NM06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell inner membrane|||Cell membrane|||Membrane|||NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/869210:MARKY_RS03405 ^@ http://purl.uniprot.org/uniprot/F2NL15 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/869210:MARKY_RS06085 ^@ http://purl.uniprot.org/uniprot/F2NQL7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/869210:MARKY_RS08660 ^@ http://purl.uniprot.org/uniprot/F2NMS3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/869210:MARKY_RS07440 ^@ http://purl.uniprot.org/uniprot/F2NPD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS05895 ^@ http://purl.uniprot.org/uniprot/F2NQI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS01975 ^@ http://purl.uniprot.org/uniprot/F2NKV3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01100 ^@ http://purl.uniprot.org/uniprot/F2NND3 ^@ Similarity ^@ Belongs to the NAD synthetase family. http://togogenome.org/gene/869210:MARKY_RS08930 ^@ http://purl.uniprot.org/uniprot/F2NPK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell inner membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/869210:MARKY_RS03795 ^@ http://purl.uniprot.org/uniprot/F2NM27 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS01670 ^@ http://purl.uniprot.org/uniprot/F2NPY1 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/869210:MARKY_RS08270 ^@ http://purl.uniprot.org/uniprot/F2NKD0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS10495 ^@ http://purl.uniprot.org/uniprot/F2NN71 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/869210:MARKY_RS02470 ^@ http://purl.uniprot.org/uniprot/F2NLX7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS10775 ^@ http://purl.uniprot.org/uniprot/F2NPT8 ^@ Cofactor ^@ Binds 1 FAD per subunit. http://togogenome.org/gene/869210:MARKY_RS06115 ^@ http://purl.uniprot.org/uniprot/F2NQM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS00940 ^@ http://purl.uniprot.org/uniprot/F2NNA2 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/869210:MARKY_RS08550 ^@ http://purl.uniprot.org/uniprot/F2NMQ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/869210:MARKY_RS01390 ^@ http://purl.uniprot.org/uniprot/F2NNL6 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/869210:MARKY_RS07850 ^@ http://purl.uniprot.org/uniprot/F2NQS9 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/869210:MARKY_RS01840 ^@ http://purl.uniprot.org/uniprot/F2NQ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS06275 ^@ http://purl.uniprot.org/uniprot/F2NK22 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/869210:MARKY_RS07120 ^@ http://purl.uniprot.org/uniprot/F2NMI3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/869210:MARKY_RS08830 ^@ http://purl.uniprot.org/uniprot/F2NPI9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/869210:MARKY_RS07660 ^@ http://purl.uniprot.org/uniprot/F2NPH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/869210:MARKY_RS03150 ^@ http://purl.uniprot.org/uniprot/F2NQ57 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Forms a 24-polypeptide structural core with octahedral symmetry.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/869210:MARKY_RS09320 ^@ http://purl.uniprot.org/uniprot/F2NR09 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/869210:MARKY_RS10530 ^@ http://purl.uniprot.org/uniprot/F2NN78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS06600 ^@ http://purl.uniprot.org/uniprot/F2NLF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS04285 ^@ http://purl.uniprot.org/uniprot/F2NP05 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/869210:MARKY_RS09840 ^@ http://purl.uniprot.org/uniprot/F2NMV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Cell membrane|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/869210:MARKY_RS08535 ^@ http://purl.uniprot.org/uniprot/F2NMP8 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/869210:MARKY_RS10630 ^@ http://purl.uniprot.org/uniprot/F2NPR1 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/869210:MARKY_RS09815 ^@ http://purl.uniprot.org/uniprot/F2NKM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01585 ^@ http://purl.uniprot.org/uniprot/F2NPW5 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/869210:MARKY_RS04930 ^@ http://purl.uniprot.org/uniprot/F2NLA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/869210:MARKY_RS02270 ^@ http://purl.uniprot.org/uniprot/F2NL03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/869210:MARKY_RS00980 ^@ http://purl.uniprot.org/uniprot/F2NNA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/869210:MARKY_RS08560 ^@ http://purl.uniprot.org/uniprot/F2NMQ3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/869210:MARKY_RS00115 ^@ http://purl.uniprot.org/uniprot/F2NNH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS05770 ^@ http://purl.uniprot.org/uniprot/F2NP93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/869210:MARKY_RS05685 ^@ http://purl.uniprot.org/uniprot/F2NP77 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/869210:MARKY_RS03565 ^@ http://purl.uniprot.org/uniprot/F2NL47 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS08040 ^@ http://purl.uniprot.org/uniprot/F2NQW9 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/869210:MARKY_RS06750 ^@ http://purl.uniprot.org/uniprot/F2NLI6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS00010 ^@ http://purl.uniprot.org/uniprot/F2NNF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/869210:MARKY_RS06285 ^@ http://purl.uniprot.org/uniprot/F2NK24 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS03125 ^@ http://purl.uniprot.org/uniprot/F2NQ52 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/869210:MARKY_RS10505 ^@ http://purl.uniprot.org/uniprot/F2NN73 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/869210:MARKY_RS08980 ^@ http://purl.uniprot.org/uniprot/F2NPL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05420 ^@ http://purl.uniprot.org/uniprot/F2NMD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell inner membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/869210:MARKY_RS07075 ^@ http://purl.uniprot.org/uniprot/F2NMH3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS05870 ^@ http://purl.uniprot.org/uniprot/F2NPB3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnC family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/869210:MARKY_RS06590 ^@ http://purl.uniprot.org/uniprot/F2NK83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05830 ^@ http://purl.uniprot.org/uniprot/F2NPA5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS05370 ^@ http://purl.uniprot.org/uniprot/F2NMC5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/869210:MARKY_RS04005 ^@ http://purl.uniprot.org/uniprot/F2NM69 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/869210:MARKY_RS08650 ^@ http://purl.uniprot.org/uniprot/F2NMS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/869210:MARKY_RS09405 ^@ http://purl.uniprot.org/uniprot/F2NR26 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/869210:MARKY_RS02930 ^@ http://purl.uniprot.org/uniprot/F2NNV1 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS00165 ^@ http://purl.uniprot.org/uniprot/F2NKN4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/869210:MARKY_RS11260 ^@ http://purl.uniprot.org/uniprot/F2NRB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS02300 ^@ http://purl.uniprot.org/uniprot/F2NL09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/869210:MARKY_RS09260 ^@ http://purl.uniprot.org/uniprot/F2NQZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS08490 ^@ http://purl.uniprot.org/uniprot/F2NMN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS07165 ^@ http://purl.uniprot.org/uniprot/F2NMJ1 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02265 ^@ http://purl.uniprot.org/uniprot/F2NL02 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/869210:MARKY_RS10200 ^@ http://purl.uniprot.org/uniprot/F2NN17 ^@ Similarity ^@ Belongs to the peptidase S58 family. http://togogenome.org/gene/869210:MARKY_RS01500 ^@ http://purl.uniprot.org/uniprot/F2NNN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS11120 ^@ http://purl.uniprot.org/uniprot/F2NR82 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/869210:MARKY_RS06300 ^@ http://purl.uniprot.org/uniprot/F2NK27 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/869210:MARKY_RS06065 ^@ http://purl.uniprot.org/uniprot/F2NQL3 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS10070 ^@ http://purl.uniprot.org/uniprot/F2NMZ2 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/869210:MARKY_RS05470 ^@ http://purl.uniprot.org/uniprot/F2NME7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS09920 ^@ http://purl.uniprot.org/uniprot/F2NMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS00445 ^@ http://purl.uniprot.org/uniprot/F2NKT4 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/869210:MARKY_RS10460 ^@ http://purl.uniprot.org/uniprot/F2NN64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03065 ^@ http://purl.uniprot.org/uniprot/F2NQ40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01230 ^@ http://purl.uniprot.org/uniprot/F2NNI5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by fructose 1,6-bisphosphate (FBP).|||Belongs to the LDH/MDH superfamily. LDH family.|||Catalyzes the conversion of lactate to pyruvate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS08325 ^@ http://purl.uniprot.org/uniprot/F2NKE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GmhB family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS09775 ^@ http://purl.uniprot.org/uniprot/F2NKL7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS03055 ^@ http://purl.uniprot.org/uniprot/F2NQ38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS06170 ^@ http://purl.uniprot.org/uniprot/F2NQN4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/869210:MARKY_RS04160 ^@ http://purl.uniprot.org/uniprot/F2NNX9 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/869210:MARKY_RS07975 ^@ http://purl.uniprot.org/uniprot/F2NQV3 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/869210:MARKY_RS09950 ^@ http://purl.uniprot.org/uniprot/F2NMX1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS10380 ^@ http://purl.uniprot.org/uniprot/F2NN49 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/869210:MARKY_RS09430 ^@ http://purl.uniprot.org/uniprot/F2NR31 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS09375 ^@ http://purl.uniprot.org/uniprot/F2NR20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS00535 ^@ http://purl.uniprot.org/uniprot/F2NLN5 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/869210:MARKY_RS07785 ^@ http://purl.uniprot.org/uniprot/F2NQR7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/869210:MARKY_RS08950 ^@ http://purl.uniprot.org/uniprot/F2NPL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS02190 ^@ http://purl.uniprot.org/uniprot/F2NKZ3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02010 ^@ http://purl.uniprot.org/uniprot/F2NKW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/869210:MARKY_RS02445 ^@ http://purl.uniprot.org/uniprot/F2NLX2 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/869210:MARKY_RS07665 ^@ http://purl.uniprot.org/uniprot/F2NPH6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/869210:MARKY_RS09695 ^@ http://purl.uniprot.org/uniprot/F2NKK1 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/869210:MARKY_RS05135 ^@ http://purl.uniprot.org/uniprot/F2NLE8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/869210:MARKY_RS08495 ^@ http://purl.uniprot.org/uniprot/F2NMP0 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/869210:MARKY_RS04960 ^@ http://purl.uniprot.org/uniprot/F2NLB4 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/869210:MARKY_RS08670 ^@ http://purl.uniprot.org/uniprot/F2NMS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/869210:MARKY_RS05900 ^@ http://purl.uniprot.org/uniprot/F2NQI2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS04225 ^@ http://purl.uniprot.org/uniprot/F2NNZ3 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/869210:MARKY_RS10485 ^@ http://purl.uniprot.org/uniprot/F2NN69 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/869210:MARKY_RS01990 ^@ http://purl.uniprot.org/uniprot/F2NKV6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/869210:MARKY_RS05430 ^@ http://purl.uniprot.org/uniprot/F2NMD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell inner membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/869210:MARKY_RS04315 ^@ http://purl.uniprot.org/uniprot/F2NP12 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/869210:MARKY_RS01225 ^@ http://purl.uniprot.org/uniprot/F2NNI4 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS03300 ^@ http://purl.uniprot.org/uniprot/F2NQ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS04770 ^@ http://purl.uniprot.org/uniprot/F2NQG7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS07240 ^@ http://purl.uniprot.org/uniprot/F2NMK4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/869210:MARKY_RS08125 ^@ http://purl.uniprot.org/uniprot/F2NKA2 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/869210:MARKY_RS03360 ^@ http://purl.uniprot.org/uniprot/F2NQ98 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS00320 ^@ http://purl.uniprot.org/uniprot/F2NKQ8 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/869210:MARKY_RS09165 ^@ http://purl.uniprot.org/uniprot/F2NQX4 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/869210:MARKY_RS09280 ^@ http://purl.uniprot.org/uniprot/F2NR01 ^@ Similarity ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/869210:MARKY_RS07820 ^@ http://purl.uniprot.org/uniprot/F2NQS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Membrane http://togogenome.org/gene/869210:MARKY_RS08665 ^@ http://purl.uniprot.org/uniprot/F2NMS4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/869210:MARKY_RS10000 ^@ http://purl.uniprot.org/uniprot/F2NMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS09380 ^@ http://purl.uniprot.org/uniprot/F2NR21 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS02580 ^@ http://purl.uniprot.org/uniprot/F2NLZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell inner membrane|||Cell membrane|||NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/869210:MARKY_RS04310 ^@ http://purl.uniprot.org/uniprot/F2NP11 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/869210:MARKY_RS03315 ^@ http://purl.uniprot.org/uniprot/F2NQ90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/869210:MARKY_RS02150 ^@ http://purl.uniprot.org/uniprot/F2NKY5 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/869210:MARKY_RS07060 ^@ http://purl.uniprot.org/uniprot/F2NMH0 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/869210:MARKY_RS04505 ^@ http://purl.uniprot.org/uniprot/F2NQB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/869210:MARKY_RS09160 ^@ http://purl.uniprot.org/uniprot/F2NQX3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/869210:MARKY_RS08330 ^@ http://purl.uniprot.org/uniprot/F2NKE2 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS10015 ^@ http://purl.uniprot.org/uniprot/F2NMY3 ^@ Function|||Similarity ^@ Belongs to the CobT family.|||Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). http://togogenome.org/gene/869210:MARKY_RS05130 ^@ http://purl.uniprot.org/uniprot/F2NLE7 ^@ Similarity ^@ Belongs to the 6-phosphogluconate dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS06910 ^@ http://purl.uniprot.org/uniprot/F2NLL1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/869210:MARKY_RS05210 ^@ http://purl.uniprot.org/uniprot/F2NM95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/869210:MARKY_RS04715 ^@ http://purl.uniprot.org/uniprot/F2NQF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS01705 ^@ http://purl.uniprot.org/uniprot/F2NPY8 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/869210:MARKY_RS04830 ^@ http://purl.uniprot.org/uniprot/F2NL88 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/869210:MARKY_RS00120 ^@ http://purl.uniprot.org/uniprot/F2NNH8 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/869210:MARKY_RS08610 ^@ http://purl.uniprot.org/uniprot/F2NMR3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/869210:MARKY_RS00135 ^@ http://purl.uniprot.org/uniprot/F2NNI1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/869210:MARKY_RS08565 ^@ http://purl.uniprot.org/uniprot/F2NMQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/869210:MARKY_RS02740 ^@ http://purl.uniprot.org/uniprot/F2NNR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS03870 ^@ http://purl.uniprot.org/uniprot/F2NM42 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS05360 ^@ http://purl.uniprot.org/uniprot/F2NMC3 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/869210:MARKY_RS06905 ^@ http://purl.uniprot.org/uniprot/F2NLL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/869210:MARKY_RS04895 ^@ http://purl.uniprot.org/uniprot/F2NLA1 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/869210:MARKY_RS11610 ^@ http://purl.uniprot.org/uniprot/F2NQD4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/869210:MARKY_RS05825 ^@ http://purl.uniprot.org/uniprot/F2NPA4 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/869210:MARKY_RS03540 ^@ http://purl.uniprot.org/uniprot/F2NL42 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/869210:MARKY_RS01645 ^@ http://purl.uniprot.org/uniprot/F2NPX6 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/869210:MARKY_RS05550 ^@ http://purl.uniprot.org/uniprot/F2NP50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03835 ^@ http://purl.uniprot.org/uniprot/F2NM35 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/869210:MARKY_RS08015 ^@ http://purl.uniprot.org/uniprot/F2NQW1 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/869210:MARKY_RS02605 ^@ http://purl.uniprot.org/uniprot/F2NM04 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/869210:MARKY_RS00485 ^@ http://purl.uniprot.org/uniprot/F2NKU2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/869210:MARKY_RS03390 ^@ http://purl.uniprot.org/uniprot/F2NQA4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS04230 ^@ http://purl.uniprot.org/uniprot/F2NNZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/869210:MARKY_RS08020 ^@ http://purl.uniprot.org/uniprot/F2NQW2 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/869210:MARKY_RS06375 ^@ http://purl.uniprot.org/uniprot/F2NK42 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/869210:MARKY_RS08835 ^@ http://purl.uniprot.org/uniprot/F2NPJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01430 ^@ http://purl.uniprot.org/uniprot/F2NNM4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/869210:MARKY_RS11445 ^@ http://purl.uniprot.org/uniprot/F2NKF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00045 ^@ http://purl.uniprot.org/uniprot/F2NNG3 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/869210:MARKY_RS01370 ^@ http://purl.uniprot.org/uniprot/F2NNL2 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/869210:MARKY_RS01510 ^@ http://purl.uniprot.org/uniprot/F2NNN7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS06745 ^@ http://purl.uniprot.org/uniprot/F2NLI5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS06355 ^@ http://purl.uniprot.org/uniprot/F2NK38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS04110 ^@ http://purl.uniprot.org/uniprot/F2NM86 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/869210:MARKY_RS01885 ^@ http://purl.uniprot.org/uniprot/F2NQ23 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS02495 ^@ http://purl.uniprot.org/uniprot/F2NLY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS02985 ^@ http://purl.uniprot.org/uniprot/F2NNW1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/869210:MARKY_RS11305 ^@ http://purl.uniprot.org/uniprot/F2NRB8 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/869210:MARKY_RS04380 ^@ http://purl.uniprot.org/uniprot/F2NP26 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/869210:MARKY_RS02280 ^@ http://purl.uniprot.org/uniprot/F2NL05 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/869210:MARKY_RS11195 ^@ http://purl.uniprot.org/uniprot/F2NR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS09460 ^@ http://purl.uniprot.org/uniprot/F2NR37 ^@ Caution|||Function|||Similarity ^@ Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.|||Belongs to the biotin--protein ligase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS04015 ^@ http://purl.uniprot.org/uniprot/F2NM71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/869210:MARKY_RS04760 ^@ http://purl.uniprot.org/uniprot/F2NQG5 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/869210:MARKY_RS08540 ^@ http://purl.uniprot.org/uniprot/F2NMP9 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/869210:MARKY_RS10435 ^@ http://purl.uniprot.org/uniprot/F2NN59 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/869210:MARKY_RS02630 ^@ http://purl.uniprot.org/uniprot/F2NM09 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/869210:MARKY_RS03560 ^@ http://purl.uniprot.org/uniprot/F2NL46 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS02260 ^@ http://purl.uniprot.org/uniprot/F2NL01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/869210:MARKY_RS02635 ^@ http://purl.uniprot.org/uniprot/F2NM10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS01600 ^@ http://purl.uniprot.org/uniprot/F2NPW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS10640 ^@ http://purl.uniprot.org/uniprot/F2NPR3 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/869210:MARKY_RS01630 ^@ http://purl.uniprot.org/uniprot/F2NPX3 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/869210:MARKY_RS04570 ^@ http://purl.uniprot.org/uniprot/F2NQC7 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/869210:MARKY_RS02275 ^@ http://purl.uniprot.org/uniprot/F2NL04 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/869210:MARKY_RS06130 ^@ http://purl.uniprot.org/uniprot/F2NQM6 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/869210:MARKY_RS09470 ^@ http://purl.uniprot.org/uniprot/F2NR39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/869210:MARKY_RS05410 ^@ http://purl.uniprot.org/uniprot/F2NMD5 ^@ Function|||Similarity ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/869210:MARKY_RS04040 ^@ http://purl.uniprot.org/uniprot/F2NM74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS05255 ^@ http://purl.uniprot.org/uniprot/F2NMA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS03710 ^@ http://purl.uniprot.org/uniprot/F2NL77 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/869210:MARKY_RS05690 ^@ http://purl.uniprot.org/uniprot/F2NP78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/869210:MARKY_RS05710 ^@ http://purl.uniprot.org/uniprot/F2NP82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05465 ^@ http://purl.uniprot.org/uniprot/F2NME6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/869210:MARKY_RS00775 ^@ http://purl.uniprot.org/uniprot/F2NLT1 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/869210:MARKY_RS05235 ^@ http://purl.uniprot.org/uniprot/F2NMA0 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/869210:MARKY_RS06940 ^@ http://purl.uniprot.org/uniprot/F2NLL7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02515 ^@ http://purl.uniprot.org/uniprot/F2NLY6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS07020 ^@ http://purl.uniprot.org/uniprot/F2NMG2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/869210:MARKY_RS04405 ^@ http://purl.uniprot.org/uniprot/F2NP31 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/869210:MARKY_RS00465 ^@ http://purl.uniprot.org/uniprot/F2NKT8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/869210:MARKY_RS01435 ^@ http://purl.uniprot.org/uniprot/F2NNM5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/869210:MARKY_RS03575 ^@ http://purl.uniprot.org/uniprot/F2NL49 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS06255 ^@ http://purl.uniprot.org/uniprot/F2NK18 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/869210:MARKY_RS06920 ^@ http://purl.uniprot.org/uniprot/F2NLL3 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/869210:MARKY_RS07090 ^@ http://purl.uniprot.org/uniprot/F2NMH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00455 ^@ http://purl.uniprot.org/uniprot/F2NKT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/869210:MARKY_RS11250 ^@ http://purl.uniprot.org/uniprot/F2NRA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS04415 ^@ http://purl.uniprot.org/uniprot/F2NP33 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/869210:MARKY_RS03875 ^@ http://purl.uniprot.org/uniprot/F2NM43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/869210:MARKY_RS07245 ^@ http://purl.uniprot.org/uniprot/F2NMK5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/869210:MARKY_RS02885 ^@ http://purl.uniprot.org/uniprot/F2NNU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/869210:MARKY_RS11130 ^@ http://purl.uniprot.org/uniprot/F2NR84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS08940 ^@ http://purl.uniprot.org/uniprot/F2NPL1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/869210:MARKY_RS01570 ^@ http://purl.uniprot.org/uniprot/F2NNP8 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/869210:MARKY_RS08740 ^@ http://purl.uniprot.org/uniprot/F2NMT9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS10875 ^@ http://purl.uniprot.org/uniprot/F2NPV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/869210:MARKY_RS06710 ^@ http://purl.uniprot.org/uniprot/F2NLH9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/869210:MARKY_RS09100 ^@ http://purl.uniprot.org/uniprot/F2NPN8 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.|||Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.|||Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Periplasm|||Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. http://togogenome.org/gene/869210:MARKY_RS09725 ^@ http://purl.uniprot.org/uniprot/F2NKK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS07745 ^@ http://purl.uniprot.org/uniprot/F2NQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial secretin family.|||Cell outer membrane http://togogenome.org/gene/869210:MARKY_RS00205 ^@ http://purl.uniprot.org/uniprot/F2NKP2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS03305 ^@ http://purl.uniprot.org/uniprot/F2NQ88 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/869210:MARKY_RS08840 ^@ http://purl.uniprot.org/uniprot/F2NPJ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS07610 ^@ http://purl.uniprot.org/uniprot/F2NPG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/869210:MARKY_RS00070 ^@ http://purl.uniprot.org/uniprot/F2NNG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS06340 ^@ http://purl.uniprot.org/uniprot/F2NK35 ^@ Similarity ^@ Belongs to the extradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/869210:MARKY_RS06965 ^@ http://purl.uniprot.org/uniprot/F2NLM2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/869210:MARKY_RS09140 ^@ http://purl.uniprot.org/uniprot/F2NPP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS02165 ^@ http://purl.uniprot.org/uniprot/F2NKY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/869210:MARKY_RS07415 ^@ http://purl.uniprot.org/uniprot/F2NPC9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/869210:MARKY_RS01580 ^@ http://purl.uniprot.org/uniprot/F2NNQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS09495 ^@ http://purl.uniprot.org/uniprot/F2NKG2 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/869210:MARKY_RS07425 ^@ http://purl.uniprot.org/uniprot/F2NPD1 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/869210:MARKY_RS09615 ^@ http://purl.uniprot.org/uniprot/F2NKI5 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/869210:MARKY_RS06935 ^@ http://purl.uniprot.org/uniprot/F2NLL6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/869210:MARKY_RS03475 ^@ http://purl.uniprot.org/uniprot/F2NL29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS10520 ^@ http://purl.uniprot.org/uniprot/F2NN76 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/869210:MARKY_RS07015 ^@ http://purl.uniprot.org/uniprot/F2NMG1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/869210:MARKY_RS09120 ^@ http://purl.uniprot.org/uniprot/F2NPP2 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/869210:MARKY_RS04825 ^@ http://purl.uniprot.org/uniprot/F2NL87 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/869210:MARKY_RS07875 ^@ http://purl.uniprot.org/uniprot/F2NQT4 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/869210:MARKY_RS03585 ^@ http://purl.uniprot.org/uniprot/F2NL51 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS00460 ^@ http://purl.uniprot.org/uniprot/F2NKT7 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/869210:MARKY_RS05800 ^@ http://purl.uniprot.org/uniprot/F2NP99 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/869210:MARKY_RS01935 ^@ http://purl.uniprot.org/uniprot/F2NKU5 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/869210:MARKY_RS04305 ^@ http://purl.uniprot.org/uniprot/F2NP10 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/869210:MARKY_RS03380 ^@ http://purl.uniprot.org/uniprot/F2NQA2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS02585 ^@ http://purl.uniprot.org/uniprot/F2NM00 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell inner membrane|||NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/869210:MARKY_RS05755 ^@ http://purl.uniprot.org/uniprot/F2NP91 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Belongs to the tRNA(Ile)-lysidine synthase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Cytoplasm|||Homodimer.|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/869210:MARKY_RS09855 ^@ http://purl.uniprot.org/uniprot/F2NMV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS06040 ^@ http://purl.uniprot.org/uniprot/F2NQK8 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/869210:MARKY_RS08645 ^@ http://purl.uniprot.org/uniprot/F2NMS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS09370 ^@ http://purl.uniprot.org/uniprot/F2NR19 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/869210:MARKY_RS04815 ^@ http://purl.uniprot.org/uniprot/F2NL85 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/869210:MARKY_RS01890 ^@ http://purl.uniprot.org/uniprot/F2NQ24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS07410 ^@ http://purl.uniprot.org/uniprot/F2NPC8 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/869210:MARKY_RS11320 ^@ http://purl.uniprot.org/uniprot/F2NRC1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/869210:MARKY_RS05405 ^@ http://purl.uniprot.org/uniprot/F2NMD4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/869210:MARKY_RS00850 ^@ http://purl.uniprot.org/uniprot/F2NN85 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/869210:MARKY_RS08005 ^@ http://purl.uniprot.org/uniprot/F2NQV9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS05540 ^@ http://purl.uniprot.org/uniprot/F2NP48 ^@ Similarity ^@ Belongs to the GreA/GreB family. http://togogenome.org/gene/869210:MARKY_RS03600 ^@ http://purl.uniprot.org/uniprot/F2NL55 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS10295 ^@ http://purl.uniprot.org/uniprot/F2NN32 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/869210:MARKY_RS02390 ^@ http://purl.uniprot.org/uniprot/F2NLW1 ^@ Similarity ^@ Belongs to the MreC family. http://togogenome.org/gene/869210:MARKY_RS03955 ^@ http://purl.uniprot.org/uniprot/F2NM59 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/869210:MARKY_RS05975 ^@ http://purl.uniprot.org/uniprot/F2NQJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS02910 ^@ http://purl.uniprot.org/uniprot/F2NNU7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/869210:MARKY_RS09510 ^@ http://purl.uniprot.org/uniprot/F2NKG6 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/869210:MARKY_RS10225 ^@ http://purl.uniprot.org/uniprot/F2NN22 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/869210:MARKY_RS01305 ^@ http://purl.uniprot.org/uniprot/F2NNK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/869210:MARKY_RS04800 ^@ http://purl.uniprot.org/uniprot/F2NQH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/869210:MARKY_RS00330 ^@ http://purl.uniprot.org/uniprot/F2NKR0 ^@ Similarity ^@ Belongs to the phosphate/phosphite/phosphonate binding protein family. http://togogenome.org/gene/869210:MARKY_RS01725 ^@ http://purl.uniprot.org/uniprot/F2NPZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02780 ^@ http://purl.uniprot.org/uniprot/F2NNS1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS07125 ^@ http://purl.uniprot.org/uniprot/F2NMI4 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/869210:MARKY_RS07840 ^@ http://purl.uniprot.org/uniprot/F2NQS7 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/869210:MARKY_RS01515 ^@ http://purl.uniprot.org/uniprot/F2NNN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 7 family.|||Homodimer.|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||Periplasm http://togogenome.org/gene/869210:MARKY_RS04335 ^@ http://purl.uniprot.org/uniprot/F2NP16 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/869210:MARKY_RS04345 ^@ http://purl.uniprot.org/uniprot/F2NP18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/869210:MARKY_RS04485 ^@ http://purl.uniprot.org/uniprot/F2NQA8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/869210:MARKY_RS03130 ^@ http://purl.uniprot.org/uniprot/F2NQ53 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/869210:MARKY_RS01795 ^@ http://purl.uniprot.org/uniprot/F2NQ04 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/869210:MARKY_RS06195 ^@ http://purl.uniprot.org/uniprot/F2NQN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS07460 ^@ http://purl.uniprot.org/uniprot/F2NPD8 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/869210:MARKY_RS02195 ^@ http://purl.uniprot.org/uniprot/F2NKZ4 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/869210:MARKY_RS07865 ^@ http://purl.uniprot.org/uniprot/F2NQT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS00240 ^@ http://purl.uniprot.org/uniprot/F2NKP6 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS09515 ^@ http://purl.uniprot.org/uniprot/F2NKG7 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/869210:MARKY_RS08150 ^@ http://purl.uniprot.org/uniprot/F2NKA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/869210:MARKY_RS09485 ^@ http://purl.uniprot.org/uniprot/F2NKG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08785 ^@ http://purl.uniprot.org/uniprot/F2NMU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS00305 ^@ http://purl.uniprot.org/uniprot/F2NKQ5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/869210:MARKY_RS01195 ^@ http://purl.uniprot.org/uniprot/F2NNF2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/869210:MARKY_RS07400 ^@ http://purl.uniprot.org/uniprot/F2NPC6 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/869210:MARKY_RS08655 ^@ http://purl.uniprot.org/uniprot/F2NMS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/869210:MARKY_RS07615 ^@ http://purl.uniprot.org/uniprot/F2NPG6 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS05215 ^@ http://purl.uniprot.org/uniprot/F2NM96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/869210:MARKY_RS08590 ^@ http://purl.uniprot.org/uniprot/F2NMQ9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS02570 ^@ http://purl.uniprot.org/uniprot/F2NLZ7 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/869210:MARKY_RS07200 ^@ http://purl.uniprot.org/uniprot/F2NMJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/869210:MARKY_RS09050 ^@ http://purl.uniprot.org/uniprot/F2NPN2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/869210:MARKY_RS07500 ^@ http://purl.uniprot.org/uniprot/F2NPE6 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/869210:MARKY_RS01025 ^@ http://purl.uniprot.org/uniprot/F2NNB8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/869210:MARKY_RS03900 ^@ http://purl.uniprot.org/uniprot/F2NM48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/869210:MARKY_RS08545 ^@ http://purl.uniprot.org/uniprot/F2NMQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/869210:MARKY_RS03350 ^@ http://purl.uniprot.org/uniprot/F2NQ96 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS00500 ^@ http://purl.uniprot.org/uniprot/F2NLM8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/869210:MARKY_RS10030 ^@ http://purl.uniprot.org/uniprot/F2NMY6 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/869210:MARKY_RS05670 ^@ http://purl.uniprot.org/uniprot/F2NP74 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/869210:MARKY_RS02830 ^@ http://purl.uniprot.org/uniprot/F2NNT1 ^@ Function|||Similarity ^@ Belongs to the Dus family. DusA subfamily.|||Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs. http://togogenome.org/gene/869210:MARKY_RS11075 ^@ http://purl.uniprot.org/uniprot/F2NR73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS10525 ^@ http://purl.uniprot.org/uniprot/F2NN77 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS06160 ^@ http://purl.uniprot.org/uniprot/F2NQN2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS10620 ^@ http://purl.uniprot.org/uniprot/F2NPQ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/869210:MARKY_RS09265 ^@ http://purl.uniprot.org/uniprot/F2NQZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS04810 ^@ http://purl.uniprot.org/uniprot/F2NQH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homotetramer. http://togogenome.org/gene/869210:MARKY_RS09035 ^@ http://purl.uniprot.org/uniprot/F2NPM9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/869210:MARKY_RS03810 ^@ http://purl.uniprot.org/uniprot/F2NM30 ^@ Similarity ^@ Belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/869210:MARKY_RS08230 ^@ http://purl.uniprot.org/uniprot/F2NKC2 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS05635 ^@ http://purl.uniprot.org/uniprot/F2NP66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08765 ^@ http://purl.uniprot.org/uniprot/F2NMU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/869210:MARKY_RS05580 ^@ http://purl.uniprot.org/uniprot/F2NP56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS09850 ^@ http://purl.uniprot.org/uniprot/F2NMV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS04000 ^@ http://purl.uniprot.org/uniprot/F2NM68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/869210:MARKY_RS11055 ^@ http://purl.uniprot.org/uniprot/F2NR69 ^@ Similarity ^@ Belongs to the Lgt family. http://togogenome.org/gene/869210:MARKY_RS03910 ^@ http://purl.uniprot.org/uniprot/F2NM50 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS08895 ^@ http://purl.uniprot.org/uniprot/F2NPK2 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/869210:MARKY_RS00125 ^@ http://purl.uniprot.org/uniprot/F2NNH9 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/869210:MARKY_RS07285 ^@ http://purl.uniprot.org/uniprot/F2NML3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS06070 ^@ http://purl.uniprot.org/uniprot/F2NQL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/869210:MARKY_RS00015 ^@ http://purl.uniprot.org/uniprot/F2NNF8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/869210:MARKY_RS04265 ^@ http://purl.uniprot.org/uniprot/F2NP01 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01000 ^@ http://purl.uniprot.org/uniprot/F2NNB3 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/869210:MARKY_RS08385 ^@ http://purl.uniprot.org/uniprot/F2NKF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/869210:MARKY_RS07295 ^@ http://purl.uniprot.org/uniprot/F2NML5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS04510 ^@ http://purl.uniprot.org/uniprot/F2NQB3 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/869210:MARKY_RS01690 ^@ http://purl.uniprot.org/uniprot/F2NPY5 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/869210:MARKY_RS11275 ^@ http://purl.uniprot.org/uniprot/F2NRB3 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/869210:MARKY_RS04435 ^@ http://purl.uniprot.org/uniprot/F2NP37 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS10540 ^@ http://purl.uniprot.org/uniprot/F2NN80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS06325 ^@ http://purl.uniprot.org/uniprot/F2NK32 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS10455 ^@ http://purl.uniprot.org/uniprot/F2NN63 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/869210:MARKY_RS00405 ^@ http://purl.uniprot.org/uniprot/F2NKS6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02020 ^@ http://purl.uniprot.org/uniprot/F2NKW2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS11240 ^@ http://purl.uniprot.org/uniprot/F2NRA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/869210:MARKY_RS06615 ^@ http://purl.uniprot.org/uniprot/F2NLG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/869210:MARKY_RS04055 ^@ http://purl.uniprot.org/uniprot/F2NM77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/869210:MARKY_RS07675 ^@ http://purl.uniprot.org/uniprot/F2NPH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/869210:MARKY_RS10935 ^@ http://purl.uniprot.org/uniprot/F2NR46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS10180 ^@ http://purl.uniprot.org/uniprot/F2NN13 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/869210:MARKY_RS01985 ^@ http://purl.uniprot.org/uniprot/F2NKV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00720 ^@ http://purl.uniprot.org/uniprot/F2NLS0 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS06420 ^@ http://purl.uniprot.org/uniprot/F2NK51 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/869210:MARKY_RS02620 ^@ http://purl.uniprot.org/uniprot/F2NM07 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/869210:MARKY_RS06815 ^@ http://purl.uniprot.org/uniprot/F2NLJ3 ^@ Similarity ^@ Belongs to the FemABX family. http://togogenome.org/gene/869210:MARKY_RS04855 ^@ http://purl.uniprot.org/uniprot/F2NL93 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/869210:MARKY_RS00845 ^@ http://purl.uniprot.org/uniprot/F2NN84 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/869210:MARKY_RS03995 ^@ http://purl.uniprot.org/uniprot/F2NM67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/869210:MARKY_RS00740 ^@ http://purl.uniprot.org/uniprot/F2NLS3 ^@ Caution|||Function|||Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.|||Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS09295 ^@ http://purl.uniprot.org/uniprot/F2NR04 ^@ Similarity ^@ Belongs to the AfsR/DnrI/RedD regulatory family. http://togogenome.org/gene/869210:MARKY_RS02395 ^@ http://purl.uniprot.org/uniprot/F2NLW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/869210:MARKY_RS08685 ^@ http://purl.uniprot.org/uniprot/F2NMS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS00340 ^@ http://purl.uniprot.org/uniprot/F2NKR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS03440 ^@ http://purl.uniprot.org/uniprot/F2NL22 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/869210:MARKY_RS07830 ^@ http://purl.uniprot.org/uniprot/F2NQS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/869210:MARKY_RS07190 ^@ http://purl.uniprot.org/uniprot/F2NMJ6 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/869210:MARKY_RS00375 ^@ http://purl.uniprot.org/uniprot/F2NKR9 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/869210:MARKY_RS09435 ^@ http://purl.uniprot.org/uniprot/F2NR32 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS10410 ^@ http://purl.uniprot.org/uniprot/F2NN54 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/869210:MARKY_RS04805 ^@ http://purl.uniprot.org/uniprot/F2NQH5 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS00315 ^@ http://purl.uniprot.org/uniprot/F2NKQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS11475 ^@ http://purl.uniprot.org/uniprot/F2NR25 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/869210:MARKY_RS01790 ^@ http://purl.uniprot.org/uniprot/F2NQ03 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/869210:MARKY_RS07310 ^@ http://purl.uniprot.org/uniprot/F2NML8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell inner membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/869210:MARKY_RS08045 ^@ http://purl.uniprot.org/uniprot/F2NK85 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/869210:MARKY_RS07330 ^@ http://purl.uniprot.org/uniprot/F2NMM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/869210:MARKY_RS08075 ^@ http://purl.uniprot.org/uniprot/F2NK91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS10075 ^@ http://purl.uniprot.org/uniprot/F2NMZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS08635 ^@ http://purl.uniprot.org/uniprot/F2NMR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS01410 ^@ http://purl.uniprot.org/uniprot/F2NNM0 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/869210:MARKY_RS08580 ^@ http://purl.uniprot.org/uniprot/F2NMQ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/869210:MARKY_RS09995 ^@ http://purl.uniprot.org/uniprot/F2NMX9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB). http://togogenome.org/gene/869210:MARKY_RS01190 ^@ http://purl.uniprot.org/uniprot/F2NNF1 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/869210:MARKY_RS02800 ^@ http://purl.uniprot.org/uniprot/F2NNS5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/869210:MARKY_RS08185 ^@ http://purl.uniprot.org/uniprot/F2NKB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS04100 ^@ http://purl.uniprot.org/uniprot/F2NM84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/869210:MARKY_RS00885 ^@ http://purl.uniprot.org/uniprot/F2NN92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03905 ^@ http://purl.uniprot.org/uniprot/F2NM49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS10310 ^@ http://purl.uniprot.org/uniprot/F2NN35 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS02485 ^@ http://purl.uniprot.org/uniprot/F2NLY0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. http://togogenome.org/gene/869210:MARKY_RS08155 ^@ http://purl.uniprot.org/uniprot/F2NKA8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS11110 ^@ http://purl.uniprot.org/uniprot/F2NR80 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/869210:MARKY_RS04560 ^@ http://purl.uniprot.org/uniprot/F2NQC4 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/869210:MARKY_RS07395 ^@ http://purl.uniprot.org/uniprot/F2NPC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS05995 ^@ http://purl.uniprot.org/uniprot/F2NQK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS09220 ^@ http://purl.uniprot.org/uniprot/F2NQY9 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/869210:MARKY_RS08050 ^@ http://purl.uniprot.org/uniprot/F2NK86 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/869210:MARKY_RS11115 ^@ http://purl.uniprot.org/uniprot/F2NR81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS03850 ^@ http://purl.uniprot.org/uniprot/F2NM38 ^@ Caution|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS09450 ^@ http://purl.uniprot.org/uniprot/F2NR35 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS10855 ^@ http://purl.uniprot.org/uniprot/F2NPV4 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/869210:MARKY_RS00380 ^@ http://purl.uniprot.org/uniprot/F2NKS0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/869210:MARKY_RS04360 ^@ http://purl.uniprot.org/uniprot/F2NP22 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/869210:MARKY_RS08120 ^@ http://purl.uniprot.org/uniprot/F2NKA1 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/869210:MARKY_RS08615 ^@ http://purl.uniprot.org/uniprot/F2NMR4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/869210:MARKY_RS01505 ^@ http://purl.uniprot.org/uniprot/F2NNN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03695 ^@ http://purl.uniprot.org/uniprot/F2NL74 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/869210:MARKY_RS10545 ^@ http://purl.uniprot.org/uniprot/F2NN81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS05965 ^@ http://purl.uniprot.org/uniprot/F2NQJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS09665 ^@ http://purl.uniprot.org/uniprot/F2NKJ5 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/869210:MARKY_RS00395 ^@ http://purl.uniprot.org/uniprot/F2NKS4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/869210:MARKY_RS07480 ^@ http://purl.uniprot.org/uniprot/F2NPE2 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/869210:MARKY_RS10625 ^@ http://purl.uniprot.org/uniprot/F2NPR0 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/869210:MARKY_RS07880 ^@ http://purl.uniprot.org/uniprot/F2NQT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/869210:MARKY_RS00680 ^@ http://purl.uniprot.org/uniprot/F2NLR2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/869210:MARKY_RS04165 ^@ http://purl.uniprot.org/uniprot/F2NNY0 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/869210:MARKY_RS06060 ^@ http://purl.uniprot.org/uniprot/F2NQL2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS06410 ^@ http://purl.uniprot.org/uniprot/F2NK49 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/869210:MARKY_RS03940 ^@ http://purl.uniprot.org/uniprot/F2NM56 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/869210:MARKY_RS02360 ^@ http://purl.uniprot.org/uniprot/F2NLV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS08975 ^@ http://purl.uniprot.org/uniprot/F2NPL7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS00820 ^@ http://purl.uniprot.org/uniprot/F2NLU0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/869210:MARKY_RS08170 ^@ http://purl.uniprot.org/uniprot/F2NKB1 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/869210:MARKY_RS08960 ^@ http://purl.uniprot.org/uniprot/F2NPL4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/869210:MARKY_RS10515 ^@ http://purl.uniprot.org/uniprot/F2NN75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS00160 ^@ http://purl.uniprot.org/uniprot/F2NKN3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/869210:MARKY_RS00005 ^@ http://purl.uniprot.org/uniprot/F2NNF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/869210:MARKY_RS04445 ^@ http://purl.uniprot.org/uniprot/F2NP39 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family. http://togogenome.org/gene/869210:MARKY_RS05885 ^@ http://purl.uniprot.org/uniprot/F2NQH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS06165 ^@ http://purl.uniprot.org/uniprot/F2NQN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/869210:MARKY_RS03420 ^@ http://purl.uniprot.org/uniprot/F2NL18 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/869210:MARKY_RS09985 ^@ http://purl.uniprot.org/uniprot/F2NMX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/869210:MARKY_RS02375 ^@ http://purl.uniprot.org/uniprot/F2NLV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/869210:MARKY_RS05845 ^@ http://purl.uniprot.org/uniprot/F2NPA8 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/869210:MARKY_RS02290 ^@ http://purl.uniprot.org/uniprot/F2NL07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/869210:MARKY_RS01680 ^@ http://purl.uniprot.org/uniprot/F2NPY3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/869210:MARKY_RS09445 ^@ http://purl.uniprot.org/uniprot/F2NR34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS04625 ^@ http://purl.uniprot.org/uniprot/F2NQD8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/869210:MARKY_RS06260 ^@ http://purl.uniprot.org/uniprot/F2NK19 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02425 ^@ http://purl.uniprot.org/uniprot/F2NLW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08675 ^@ http://purl.uniprot.org/uniprot/F2NMS6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS07055 ^@ http://purl.uniprot.org/uniprot/F2NMG9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS05705 ^@ http://purl.uniprot.org/uniprot/F2NP81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. http://togogenome.org/gene/869210:MARKY_RS00770 ^@ http://purl.uniprot.org/uniprot/F2NLT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS00545 ^@ http://purl.uniprot.org/uniprot/F2NLN7 ^@ Similarity ^@ Belongs to the BshC family. http://togogenome.org/gene/869210:MARKY_RS04680 ^@ http://purl.uniprot.org/uniprot/F2NQE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00040 ^@ http://purl.uniprot.org/uniprot/F2NNG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS10345 ^@ http://purl.uniprot.org/uniprot/F2NN42 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/869210:MARKY_RS05545 ^@ http://purl.uniprot.org/uniprot/F2NP49 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS01150 ^@ http://purl.uniprot.org/uniprot/F2NNE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS05675 ^@ http://purl.uniprot.org/uniprot/F2NP75 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/869210:MARKY_RS10240 ^@ http://purl.uniprot.org/uniprot/F2NN24 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/869210:MARKY_RS10090 ^@ http://purl.uniprot.org/uniprot/F2NMZ6 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/869210:MARKY_RS02775 ^@ http://purl.uniprot.org/uniprot/F2NNS0 ^@ Similarity|||Subunit ^@ Belongs to the multicopper oxidase family.|||Homotrimer. http://togogenome.org/gene/869210:MARKY_RS07510 ^@ http://purl.uniprot.org/uniprot/F2NPE8 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS05645 ^@ http://purl.uniprot.org/uniprot/F2NP68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/869210:MARKY_RS05075 ^@ http://purl.uniprot.org/uniprot/F2NLD7 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/869210:MARKY_RS07030 ^@ http://purl.uniprot.org/uniprot/F2NMG4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS04515 ^@ http://purl.uniprot.org/uniprot/F2NQB4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/869210:MARKY_RS09490 ^@ http://purl.uniprot.org/uniprot/F2NKG1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS05115 ^@ http://purl.uniprot.org/uniprot/F2NLE5 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/869210:MARKY_RS07175 ^@ http://purl.uniprot.org/uniprot/F2NMJ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS05400 ^@ http://purl.uniprot.org/uniprot/F2NMD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS10425 ^@ http://purl.uniprot.org/uniprot/F2NN57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/869210:MARKY_RS02880 ^@ http://purl.uniprot.org/uniprot/F2NNU1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/869210:MARKY_RS05040 ^@ http://purl.uniprot.org/uniprot/F2NLD0 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01135 ^@ http://purl.uniprot.org/uniprot/F2NNE0 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/869210:MARKY_RS05640 ^@ http://purl.uniprot.org/uniprot/F2NP67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS02110 ^@ http://purl.uniprot.org/uniprot/F2NKX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/869210:MARKY_RS03500 ^@ http://purl.uniprot.org/uniprot/F2NL34 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/869210:MARKY_RS01755 ^@ http://purl.uniprot.org/uniprot/F2NPZ8 ^@ Function ^@ Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/869210:MARKY_RS01285 ^@ http://purl.uniprot.org/uniprot/F2NNJ6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS06630 ^@ http://purl.uniprot.org/uniprot/F2NLG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS4 family.|||Membrane|||centrosome|||cilium membrane http://togogenome.org/gene/869210:MARKY_RS06400 ^@ http://purl.uniprot.org/uniprot/F2NK47 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/869210:MARKY_RS04780 ^@ http://purl.uniprot.org/uniprot/F2NQG9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS03345 ^@ http://purl.uniprot.org/uniprot/F2NQ95 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/869210:MARKY_RS06000 ^@ http://purl.uniprot.org/uniprot/F2NQK1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/869210:MARKY_RS08775 ^@ http://purl.uniprot.org/uniprot/F2NMU6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/869210:MARKY_RS06180 ^@ http://purl.uniprot.org/uniprot/F2NQN6 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/869210:MARKY_RS04585 ^@ http://purl.uniprot.org/uniprot/F2NQD0 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS02920 ^@ http://purl.uniprot.org/uniprot/F2NNU9 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/869210:MARKY_RS01945 ^@ http://purl.uniprot.org/uniprot/F2NKU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/869210:MARKY_RS02450 ^@ http://purl.uniprot.org/uniprot/F2NLX3 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/869210:MARKY_RS06310 ^@ http://purl.uniprot.org/uniprot/F2NK29 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/869210:MARKY_RS10420 ^@ http://purl.uniprot.org/uniprot/F2NN56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/869210:MARKY_RS01560 ^@ http://purl.uniprot.org/uniprot/F2NNP6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/869210:MARKY_RS03245 ^@ http://purl.uniprot.org/uniprot/F2NQ76 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/869210:MARKY_RS07445 ^@ http://purl.uniprot.org/uniprot/F2NPD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS08420 ^@ http://purl.uniprot.org/uniprot/F2NMM5 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/869210:MARKY_RS03135 ^@ http://purl.uniprot.org/uniprot/F2NQ54 ^@ Function ^@ The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/869210:MARKY_RS09325 ^@ http://purl.uniprot.org/uniprot/F2NR10 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/869210:MARKY_RS02045 ^@ http://purl.uniprot.org/uniprot/F2NKW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS00300 ^@ http://purl.uniprot.org/uniprot/F2NKQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/869210:MARKY_RS02385 ^@ http://purl.uniprot.org/uniprot/F2NLW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS00515 ^@ http://purl.uniprot.org/uniprot/F2NLN1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/869210:MARKY_RS07890 ^@ http://purl.uniprot.org/uniprot/F2NQT6 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/869210:MARKY_RS02185 ^@ http://purl.uniprot.org/uniprot/F2NKZ2 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/869210:MARKY_RS02235 ^@ http://purl.uniprot.org/uniprot/F2NL00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08175 ^@ http://purl.uniprot.org/uniprot/F2NKB2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/869210:MARKY_RS05990 ^@ http://purl.uniprot.org/uniprot/F2NQJ9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS03650 ^@ http://purl.uniprot.org/uniprot/F2NL65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/869210:MARKY_RS01060 ^@ http://purl.uniprot.org/uniprot/F2NNC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS06925 ^@ http://purl.uniprot.org/uniprot/F2NLL4 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/869210:MARKY_RS10895 ^@ http://purl.uniprot.org/uniprot/F2NPW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/869210:MARKY_RS02065 ^@ http://purl.uniprot.org/uniprot/F2NKW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00020 ^@ http://purl.uniprot.org/uniprot/F2NNF9 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/869210:MARKY_RS09570 ^@ http://purl.uniprot.org/uniprot/F2NKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS11315 ^@ http://purl.uniprot.org/uniprot/F2NRC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/869210:MARKY_RS00425 ^@ http://purl.uniprot.org/uniprot/F2NKT0 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/869210:MARKY_RS05035 ^@ http://purl.uniprot.org/uniprot/F2NLC9 ^@ Similarity ^@ Belongs to the RecO family. http://togogenome.org/gene/869210:MARKY_RS10975 ^@ http://purl.uniprot.org/uniprot/F2NR53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03815 ^@ http://purl.uniprot.org/uniprot/F2NM31 ^@ Function|||Similarity ^@ Belongs to the trehalose phosphatase family.|||Removes the phosphate from trehalose 6-phosphate to produce free trehalose. http://togogenome.org/gene/869210:MARKY_RS04155 ^@ http://purl.uniprot.org/uniprot/F2NNX8 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/869210:MARKY_RS09550 ^@ http://purl.uniprot.org/uniprot/F2NKH4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS02160 ^@ http://purl.uniprot.org/uniprot/F2NKY7 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/869210:MARKY_RS08390 ^@ http://purl.uniprot.org/uniprot/F2NKF4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05970 ^@ http://purl.uniprot.org/uniprot/F2NQJ5 ^@ Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/869210:MARKY_RS09195 ^@ http://purl.uniprot.org/uniprot/F2NQY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS05120 ^@ http://purl.uniprot.org/uniprot/F2NLE6 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/869210:MARKY_RS00925 ^@ http://purl.uniprot.org/uniprot/F2NN99 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/869210:MARKY_RS05655 ^@ http://purl.uniprot.org/uniprot/F2NP71 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/869210:MARKY_RS04640 ^@ http://purl.uniprot.org/uniprot/F2NQE1 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/869210:MARKY_RS04545 ^@ http://purl.uniprot.org/uniprot/F2NQC1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/869210:MARKY_RS07205 ^@ http://purl.uniprot.org/uniprot/F2NMJ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/869210:MARKY_RS01540 ^@ http://purl.uniprot.org/uniprot/F2NNP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01065 ^@ http://purl.uniprot.org/uniprot/F2NNC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS01415 ^@ http://purl.uniprot.org/uniprot/F2NNM1 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/869210:MARKY_RS04540 ^@ http://purl.uniprot.org/uniprot/F2NQC0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/869210:MARKY_RS06985 ^@ http://purl.uniprot.org/uniprot/F2NLM6 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/869210:MARKY_RS09345 ^@ http://purl.uniprot.org/uniprot/F2NR14 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/869210:MARKY_RS00495 ^@ http://purl.uniprot.org/uniprot/F2NKU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03895 ^@ http://purl.uniprot.org/uniprot/F2NM47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DsbB family. BdbC subfamily.|||Cell inner membrane|||Membrane|||Required for disulfide bond formation in some proteins. http://togogenome.org/gene/869210:MARKY_RS10355 ^@ http://purl.uniprot.org/uniprot/F2NN44 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS03165 ^@ http://purl.uniprot.org/uniprot/F2NQ60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS04340 ^@ http://purl.uniprot.org/uniprot/F2NP17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/869210:MARKY_RS07000 ^@ http://purl.uniprot.org/uniprot/F2NMF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS08690 ^@ http://purl.uniprot.org/uniprot/F2NL01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/869210:MARKY_RS01745 ^@ http://purl.uniprot.org/uniprot/F2NPZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/869210:MARKY_RS04555 ^@ http://purl.uniprot.org/uniprot/F2NQC3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/869210:MARKY_RS06440 ^@ http://purl.uniprot.org/uniprot/F2NK55 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS09870 ^@ http://purl.uniprot.org/uniprot/F2NMV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS09830 ^@ http://purl.uniprot.org/uniprot/F2NKM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. http://togogenome.org/gene/869210:MARKY_RS08475 ^@ http://purl.uniprot.org/uniprot/F2NMN6 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/869210:MARKY_RS04010 ^@ http://purl.uniprot.org/uniprot/F2NM70 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/869210:MARKY_RS03425 ^@ http://purl.uniprot.org/uniprot/F2NL19 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/869210:MARKY_RS09540 ^@ http://purl.uniprot.org/uniprot/F2NKH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS09780 ^@ http://purl.uniprot.org/uniprot/F2NKL8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/869210:MARKY_RS10290 ^@ http://purl.uniprot.org/uniprot/F2NN31 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS08570 ^@ http://purl.uniprot.org/uniprot/F2NMQ5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/869210:MARKY_RS10020 ^@ http://purl.uniprot.org/uniprot/F2NMY4 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/869210:MARKY_RS04395 ^@ http://purl.uniprot.org/uniprot/F2NP29 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS05070 ^@ http://purl.uniprot.org/uniprot/F2NLD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS08190 ^@ http://purl.uniprot.org/uniprot/F2NKB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS09360 ^@ http://purl.uniprot.org/uniprot/F2NR17 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS01275 ^@ http://purl.uniprot.org/uniprot/F2NNJ4 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrB family. http://togogenome.org/gene/869210:MARKY_RS02305 ^@ http://purl.uniprot.org/uniprot/F2NL10 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/869210:MARKY_RS07490 ^@ http://purl.uniprot.org/uniprot/F2NPE4 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/869210:MARKY_RS06640 ^@ http://purl.uniprot.org/uniprot/F2NLG5 ^@ Similarity ^@ Belongs to the peptidase T1B family. HslV subfamily. http://togogenome.org/gene/869210:MARKY_RS02295 ^@ http://purl.uniprot.org/uniprot/F2NL08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/869210:MARKY_RS08235 ^@ http://purl.uniprot.org/uniprot/F2NKC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS05105 ^@ http://purl.uniprot.org/uniprot/F2NLE3 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/869210:MARKY_RS07985 ^@ http://purl.uniprot.org/uniprot/F2NQV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS09880 ^@ http://purl.uniprot.org/uniprot/F2NMV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03935 ^@ http://purl.uniprot.org/uniprot/F2NM55 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/869210:MARKY_RS00510 ^@ http://purl.uniprot.org/uniprot/F2NLN0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/869210:MARKY_RS07050 ^@ http://purl.uniprot.org/uniprot/F2NMG8 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/869210:MARKY_RS08480 ^@ http://purl.uniprot.org/uniprot/F2NMN7 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/869210:MARKY_RS08100 ^@ http://purl.uniprot.org/uniprot/F2NK96 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/869210:MARKY_RS03310 ^@ http://purl.uniprot.org/uniprot/F2NQ89 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/869210:MARKY_RS00290 ^@ http://purl.uniprot.org/uniprot/F2NKQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS01470 ^@ http://purl.uniprot.org/uniprot/F2NNM9 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/869210:MARKY_RS02085 ^@ http://purl.uniprot.org/uniprot/F2NKX2 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/869210:MARKY_RS00215 ^@ http://purl.uniprot.org/uniprot/F2NKP4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/869210:MARKY_RS04430 ^@ http://purl.uniprot.org/uniprot/F2NP36 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/869210:MARKY_RS06635 ^@ http://purl.uniprot.org/uniprot/F2NLG4 ^@ Similarity ^@ Belongs to the ClpX chaperone family. HslU subfamily. http://togogenome.org/gene/869210:MARKY_RS08680 ^@ http://purl.uniprot.org/uniprot/F2NMS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/869210:MARKY_RS04280 ^@ http://purl.uniprot.org/uniprot/F2NP04 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/869210:MARKY_RS10850 ^@ http://purl.uniprot.org/uniprot/F2NPV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS04600 ^@ http://purl.uniprot.org/uniprot/F2NQD3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS09835 ^@ http://purl.uniprot.org/uniprot/F2NMV0 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell inner membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/869210:MARKY_RS04270 ^@ http://purl.uniprot.org/uniprot/F2NP02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/869210:MARKY_RS06695 ^@ http://purl.uniprot.org/uniprot/F2NLH6 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. http://togogenome.org/gene/869210:MARKY_RS07635 ^@ http://purl.uniprot.org/uniprot/F2NPH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS07455 ^@ http://purl.uniprot.org/uniprot/F2NPD7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnE family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. http://togogenome.org/gene/869210:MARKY_RS05240 ^@ http://purl.uniprot.org/uniprot/F2NMA1 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/869210:MARKY_RS05750 ^@ http://purl.uniprot.org/uniprot/F2NP90 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/869210:MARKY_RS07515 ^@ http://purl.uniprot.org/uniprot/F2NPE9 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/869210:MARKY_RS09885 ^@ http://purl.uniprot.org/uniprot/F2NMW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.|||Cell inner membrane|||Forms a complex with DabB.|||Part of an energy-coupled inorganic carbon pump. http://togogenome.org/gene/869210:MARKY_RS00055 ^@ http://purl.uniprot.org/uniprot/F2NNG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS02345 ^@ http://purl.uniprot.org/uniprot/F2NLV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmE/CycJ family.|||Cell inner membrane|||Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. http://togogenome.org/gene/869210:MARKY_RS07965 ^@ http://purl.uniprot.org/uniprot/F2NQV1 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/869210:MARKY_RS04045 ^@ http://purl.uniprot.org/uniprot/F2NM75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/869210:MARKY_RS09215 ^@ http://purl.uniprot.org/uniprot/F2NQY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.|||Membrane http://togogenome.org/gene/869210:MARKY_RS01355 ^@ http://purl.uniprot.org/uniprot/F2NNK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/869210:MARKY_RS09965 ^@ http://purl.uniprot.org/uniprot/F2NMX3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05095 ^@ http://purl.uniprot.org/uniprot/F2NLE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS02335 ^@ http://purl.uniprot.org/uniprot/F2NLU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmB/CycW/HelB family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/869210:MARKY_RS00605 ^@ http://purl.uniprot.org/uniprot/F2NLP9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/869210:MARKY_RS07805 ^@ http://purl.uniprot.org/uniprot/F2NQS0 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/869210:MARKY_RS03985 ^@ http://purl.uniprot.org/uniprot/F2NM65 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/869210:MARKY_RS08805 ^@ http://purl.uniprot.org/uniprot/F2NPI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS07065 ^@ http://purl.uniprot.org/uniprot/F2NMH1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05920 ^@ http://purl.uniprot.org/uniprot/F2NQI6 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/869210:MARKY_RS07195 ^@ http://purl.uniprot.org/uniprot/F2NMJ7 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/869210:MARKY_RS03020 ^@ http://purl.uniprot.org/uniprot/F2NNW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/869210:MARKY_RS01220 ^@ http://purl.uniprot.org/uniprot/F2NNI3 ^@ Similarity ^@ Belongs to the aldolase LacD family. http://togogenome.org/gene/869210:MARKY_RS08850 ^@ http://purl.uniprot.org/uniprot/F2NPJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS02105 ^@ http://purl.uniprot.org/uniprot/F2NKX6 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/869210:MARKY_RS06110 ^@ http://purl.uniprot.org/uniprot/F2NQM2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS05985 ^@ http://purl.uniprot.org/uniprot/F2NQJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/869210:MARKY_RS09170 ^@ http://purl.uniprot.org/uniprot/F2NQX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS09810 ^@ http://purl.uniprot.org/uniprot/F2NKM4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase S45 family.|||Binds 1 Ca(2+) ion per dimer. http://togogenome.org/gene/869210:MARKY_RS01365 ^@ http://purl.uniprot.org/uniprot/F2NNL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS02545 ^@ http://purl.uniprot.org/uniprot/F2NLZ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/869210:MARKY_RS04350 ^@ http://purl.uniprot.org/uniprot/F2NP20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/869210:MARKY_RS01995 ^@ http://purl.uniprot.org/uniprot/F2NKV7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/869210:MARKY_RS10375 ^@ http://purl.uniprot.org/uniprot/F2NN48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03030 ^@ http://purl.uniprot.org/uniprot/F2NQ33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/869210:MARKY_RS05015 ^@ http://purl.uniprot.org/uniprot/F2NLC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell inner membrane|||Probably interacts with PlsX. http://togogenome.org/gene/869210:MARKY_RS10010 ^@ http://purl.uniprot.org/uniprot/F2NMY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell inner membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/869210:MARKY_RS06570 ^@ http://purl.uniprot.org/uniprot/F2NK78 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/869210:MARKY_RS00575 ^@ http://purl.uniprot.org/uniprot/F2NLP3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/869210:MARKY_RS04370 ^@ http://purl.uniprot.org/uniprot/F2NP24 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/869210:MARKY_RS00400 ^@ http://purl.uniprot.org/uniprot/F2NKS5 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/869210:MARKY_RS10940 ^@ http://purl.uniprot.org/uniprot/F2NR47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS05950 ^@ http://purl.uniprot.org/uniprot/F2NQJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS06020 ^@ http://purl.uniprot.org/uniprot/F2NQK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/869210:MARKY_RS06380 ^@ http://purl.uniprot.org/uniprot/F2NK43 ^@ Function|||Similarity ^@ Belongs to the phenylacetyl-CoA ligase family.|||Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). http://togogenome.org/gene/869210:MARKY_RS06140 ^@ http://purl.uniprot.org/uniprot/F2NQM8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS06200 ^@ http://purl.uniprot.org/uniprot/F2NQP0 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/869210:MARKY_RS11160 ^@ http://purl.uniprot.org/uniprot/F2NR90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS01635 ^@ http://purl.uniprot.org/uniprot/F2NPX4 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/869210:MARKY_RS06715 ^@ http://purl.uniprot.org/uniprot/F2NLI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/869210:MARKY_RS11020 ^@ http://purl.uniprot.org/uniprot/F2NR62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS08240 ^@ http://purl.uniprot.org/uniprot/F2NKC4 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/869210:MARKY_RS06795 ^@ http://purl.uniprot.org/uniprot/F2NLJ0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/869210:MARKY_RS01640 ^@ http://purl.uniprot.org/uniprot/F2NPX5 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/869210:MARKY_RS02520 ^@ http://purl.uniprot.org/uniprot/F2NLY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/869210:MARKY_RS08470 ^@ http://purl.uniprot.org/uniprot/F2NMN5 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/869210:MARKY_RS01380 ^@ http://purl.uniprot.org/uniprot/F2NNL4 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/869210:MARKY_RS02115 ^@ http://purl.uniprot.org/uniprot/F2NKX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS01525 ^@ http://purl.uniprot.org/uniprot/F2NNP0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/869210:MARKY_RS02285 ^@ http://purl.uniprot.org/uniprot/F2NL06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/869210:MARKY_RS00890 ^@ http://purl.uniprot.org/uniprot/F2NN93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/869210:MARKY_RS02120 ^@ http://purl.uniprot.org/uniprot/F2NKX9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/869210:MARKY_RS06090 ^@ http://purl.uniprot.org/uniprot/F2NQL8 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/869210:MARKY_RS02430 ^@ http://purl.uniprot.org/uniprot/F2NLW9 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/869210:MARKY_RS04710 ^@ http://purl.uniprot.org/uniprot/F2NQF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS02625 ^@ http://purl.uniprot.org/uniprot/F2NM08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/869210:MARKY_RS01385 ^@ http://purl.uniprot.org/uniprot/F2NNL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/869210:MARKY_RS07315 ^@ http://purl.uniprot.org/uniprot/F2NML9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/869210:MARKY_RS05725 ^@ http://purl.uniprot.org/uniprot/F2NP85 ^@ Similarity ^@ Belongs to the prephenate/arogenate dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS09530 ^@ http://purl.uniprot.org/uniprot/F2NKH0 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. http://togogenome.org/gene/869210:MARKY_RS10765 ^@ http://purl.uniprot.org/uniprot/F2NPT6 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/869210:MARKY_RS08060 ^@ http://purl.uniprot.org/uniprot/F2NK88 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/869210:MARKY_RS09520 ^@ http://purl.uniprot.org/uniprot/F2NKG8 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/869210:MARKY_RS07290 ^@ http://purl.uniprot.org/uniprot/F2NML4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS01040 ^@ http://purl.uniprot.org/uniprot/F2NNC1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/869210:MARKY_RS00675 ^@ http://purl.uniprot.org/uniprot/F2NLR1 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/869210:MARKY_RS00700 ^@ http://purl.uniprot.org/uniprot/F2NLR6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS05795 ^@ http://purl.uniprot.org/uniprot/F2NP98 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS00685 ^@ http://purl.uniprot.org/uniprot/F2NLR3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/869210:MARKY_RS10510 ^@ http://purl.uniprot.org/uniprot/F2NN74 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/869210:MARKY_RS00660 ^@ http://purl.uniprot.org/uniprot/F2NLR0 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/869210:MARKY_RS07770 ^@ http://purl.uniprot.org/uniprot/F2NQR4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/869210:MARKY_RS09105 ^@ http://purl.uniprot.org/uniprot/F2NPN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NapB family.|||Periplasm http://togogenome.org/gene/869210:MARKY_RS09355 ^@ http://purl.uniprot.org/uniprot/F2NR16 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/869210:MARKY_RS09475 ^@ http://purl.uniprot.org/uniprot/F2NR40 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS07835 ^@ http://purl.uniprot.org/uniprot/F2NQS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/869210:MARKY_RS10825 ^@ http://purl.uniprot.org/uniprot/F2NPU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03210 ^@ http://purl.uniprot.org/uniprot/F2NQ69 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/869210:MARKY_RS05680 ^@ http://purl.uniprot.org/uniprot/F2NP76 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/869210:MARKY_RS00715 ^@ http://purl.uniprot.org/uniprot/F2NLR9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/869210:MARKY_RS01140 ^@ http://purl.uniprot.org/uniprot/F2NNE1 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/869210:MARKY_RS04275 ^@ http://purl.uniprot.org/uniprot/F2NP03 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/869210:MARKY_RS03435 ^@ http://purl.uniprot.org/uniprot/F2NL21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS08595 ^@ http://purl.uniprot.org/uniprot/F2NMR0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/869210:MARKY_RS04140 ^@ http://purl.uniprot.org/uniprot/F2NNX4 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/869210:MARKY_RS00610 ^@ http://purl.uniprot.org/uniprot/F2NLQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell inner membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/869210:MARKY_RS09675 ^@ http://purl.uniprot.org/uniprot/F2NKJ7 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/869210:MARKY_RS09155 ^@ http://purl.uniprot.org/uniprot/F2NQX2 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS11255 ^@ http://purl.uniprot.org/uniprot/F2NRA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS08630 ^@ http://purl.uniprot.org/uniprot/F2NMR7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/869210:MARKY_RS10045 ^@ http://purl.uniprot.org/uniprot/F2NMY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/869210:MARKY_RS04115 ^@ http://purl.uniprot.org/uniprot/F2NM87 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/869210:MARKY_RS03570 ^@ http://purl.uniprot.org/uniprot/F2NL48 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Cell outer membrane|||Membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS07420 ^@ http://purl.uniprot.org/uniprot/F2NPD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/869210:MARKY_RS10335 ^@ http://purl.uniprot.org/uniprot/F2NN40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/869210:MARKY_RS10350 ^@ http://purl.uniprot.org/uniprot/F2NN43 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS07655 ^@ http://purl.uniprot.org/uniprot/F2NPH4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/869210:MARKY_RS05805 ^@ http://purl.uniprot.org/uniprot/F2NPA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS09115 ^@ http://purl.uniprot.org/uniprot/F2NPP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NapD family.|||Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.|||Cytoplasm|||Interacts with the cytoplasmic NapA precursor. http://togogenome.org/gene/869210:MARKY_RS06360 ^@ http://purl.uniprot.org/uniprot/F2NK39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS07250 ^@ http://purl.uniprot.org/uniprot/F2NMK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/869210:MARKY_RS04525 ^@ http://purl.uniprot.org/uniprot/F2NQB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS00800 ^@ http://purl.uniprot.org/uniprot/F2NLT6 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS00815 ^@ http://purl.uniprot.org/uniprot/F2NLT9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/869210:MARKY_RS07670 ^@ http://purl.uniprot.org/uniprot/F2NPH7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/869210:MARKY_RS04795 ^@ http://purl.uniprot.org/uniprot/F2NQH3 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/869210:MARKY_RS00105 ^@ http://purl.uniprot.org/uniprot/F2NNH5 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS09180 ^@ http://purl.uniprot.org/uniprot/F2NQX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS06960 ^@ http://purl.uniprot.org/uniprot/F2NLM1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/869210:MARKY_RS05290 ^@ http://purl.uniprot.org/uniprot/F2NMA9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/869210:MARKY_RS05200 ^@ http://purl.uniprot.org/uniprot/F2NM93 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/869210:MARKY_RS09980 ^@ http://purl.uniprot.org/uniprot/F2NMX6 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/869210:MARKY_RS01965 ^@ http://purl.uniprot.org/uniprot/F2NKV1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pseudouridine-5'-phosphate glycosidase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.|||Homotrimer. http://togogenome.org/gene/869210:MARKY_RS08300 ^@ http://purl.uniprot.org/uniprot/F2NKD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/869210:MARKY_RS02810 ^@ http://purl.uniprot.org/uniprot/F2NNS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS03430 ^@ http://purl.uniprot.org/uniprot/F2NL20 ^@ Function|||Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.|||Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. http://togogenome.org/gene/869210:MARKY_RS11000 ^@ http://purl.uniprot.org/uniprot/F2NR58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LamB/PxpA family.|||Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.|||Forms a complex composed of PxpA, PxpB and PxpC. http://togogenome.org/gene/869210:MARKY_RS07045 ^@ http://purl.uniprot.org/uniprot/F2NMG7 ^@ Function|||Similarity ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. http://togogenome.org/gene/869210:MARKY_RS01735 ^@ http://purl.uniprot.org/uniprot/F2NPZ4 ^@ Function ^@ Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/869210:MARKY_RS08755 ^@ http://purl.uniprot.org/uniprot/F2NMU2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS04950 ^@ http://purl.uniprot.org/uniprot/F2NLB2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/869210:MARKY_RS07300 ^@ http://purl.uniprot.org/uniprot/F2NML6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS02370 ^@ http://purl.uniprot.org/uniprot/F2NLV6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/869210:MARKY_RS08925 ^@ http://purl.uniprot.org/uniprot/F2NPK8 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/869210:MARKY_RS05630 ^@ http://purl.uniprot.org/uniprot/F2NP65 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/869210:MARKY_RS06125 ^@ http://purl.uniprot.org/uniprot/F2NQM5 ^@ Similarity ^@ Belongs to the malate synthase family. http://togogenome.org/gene/869210:MARKY_RS05555 ^@ http://purl.uniprot.org/uniprot/F2NP51 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/869210:MARKY_RS03800 ^@ http://purl.uniprot.org/uniprot/F2NM28 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/869210:MARKY_RS10415 ^@ http://purl.uniprot.org/uniprot/F2NN55 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/869210:MARKY_RS08295 ^@ http://purl.uniprot.org/uniprot/F2NKD5 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/869210:MARKY_RS02845 ^@ http://purl.uniprot.org/uniprot/F2NNT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/869210:MARKY_RS07895 ^@ http://purl.uniprot.org/uniprot/F2NQT7 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/869210:MARKY_RS10370 ^@ http://purl.uniprot.org/uniprot/F2NN47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00170 ^@ http://purl.uniprot.org/uniprot/F2NKN5 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/869210:MARKY_RS06785 ^@ http://purl.uniprot.org/uniprot/F2NLI9 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/869210:MARKY_RS02060 ^@ http://purl.uniprot.org/uniprot/F2NKW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08260 ^@ http://purl.uniprot.org/uniprot/F2NKC8 ^@ Similarity|||Subunit ^@ Belongs to the beta-eliminating lyase family.|||Homotetramer. http://togogenome.org/gene/869210:MARKY_RS01950 ^@ http://purl.uniprot.org/uniprot/F2NKU8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/869210:MARKY_RS09455 ^@ http://purl.uniprot.org/uniprot/F2NR36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS02790 ^@ http://purl.uniprot.org/uniprot/F2NNS3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/869210:MARKY_RS02550 ^@ http://purl.uniprot.org/uniprot/F2NLZ3 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/869210:MARKY_RS04620 ^@ http://purl.uniprot.org/uniprot/F2NQD7 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/869210:MARKY_RS08625 ^@ http://purl.uniprot.org/uniprot/F2NMR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/869210:MARKY_RS00600 ^@ http://purl.uniprot.org/uniprot/F2NLP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/869210:MARKY_RS10430 ^@ http://purl.uniprot.org/uniprot/F2NN58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03170 ^@ http://purl.uniprot.org/uniprot/F2NQ61 ^@ Caution|||Function|||Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.|||Catalyzes the biosynthesis of agmatine from arginine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS04200 ^@ http://purl.uniprot.org/uniprot/F2NNY7 ^@ Similarity ^@ Belongs to the dGTPase family. Type 2 subfamily. http://togogenome.org/gene/869210:MARKY_RS03400 ^@ http://purl.uniprot.org/uniprot/F2NL14 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS07335 ^@ http://purl.uniprot.org/uniprot/F2NMM3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/869210:MARKY_RS01910 ^@ http://purl.uniprot.org/uniprot/F2NQ28 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/869210:MARKY_RS08600 ^@ http://purl.uniprot.org/uniprot/F2NMR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/869210:MARKY_RS05440 ^@ http://purl.uniprot.org/uniprot/F2NME1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/869210:MARKY_RS10905 ^@ http://purl.uniprot.org/uniprot/F2NPW3 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/869210:MARKY_RS05345 ^@ http://purl.uniprot.org/uniprot/F2NMC0 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/869210:MARKY_RS10385 ^@ http://purl.uniprot.org/uniprot/F2NN50 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS06535 ^@ http://purl.uniprot.org/uniprot/F2NK71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS00110 ^@ http://purl.uniprot.org/uniprot/F2NNH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS03240 ^@ http://purl.uniprot.org/uniprot/F2NQ75 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/869210:MARKY_RS09200 ^@ http://purl.uniprot.org/uniprot/F2NQY5 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/869210:MARKY_RS01710 ^@ http://purl.uniprot.org/uniprot/F2NPY9 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/869210:MARKY_RS06425 ^@ http://purl.uniprot.org/uniprot/F2NK52 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/869210:MARKY_RS00790 ^@ http://purl.uniprot.org/uniprot/F2NLT4 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Periplasm http://togogenome.org/gene/869210:MARKY_RS06575 ^@ http://purl.uniprot.org/uniprot/F2NK79 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/869210:MARKY_RS02895 ^@ http://purl.uniprot.org/uniprot/F2NNU4 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/869210:MARKY_RS08575 ^@ http://purl.uniprot.org/uniprot/F2NMQ6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/869210:MARKY_RS00210 ^@ http://purl.uniprot.org/uniprot/F2NKP3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/869210:MARKY_RS07625 ^@ http://purl.uniprot.org/uniprot/F2NPG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS05250 ^@ http://purl.uniprot.org/uniprot/F2NMA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS08695 ^@ http://purl.uniprot.org/uniprot/F2NMT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS01940 ^@ http://purl.uniprot.org/uniprot/F2NKU6 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/869210:MARKY_RS12060 ^@ http://purl.uniprot.org/uniprot/F2NQ77 ^@ Similarity ^@ Belongs to the FUN14 family. http://togogenome.org/gene/869210:MARKY_RS08555 ^@ http://purl.uniprot.org/uniprot/F2NMQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/869210:MARKY_RS08965 ^@ http://purl.uniprot.org/uniprot/F2NPL5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/869210:MARKY_RS05925 ^@ http://purl.uniprot.org/uniprot/F2NQI7 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/869210:MARKY_RS04790 ^@ http://purl.uniprot.org/uniprot/F2NQH1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/869210:MARKY_RS02200 ^@ http://purl.uniprot.org/uniprot/F2NKZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/869210:MARKY_RS04965 ^@ http://purl.uniprot.org/uniprot/F2NLB5 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/869210:MARKY_RS04785 ^@ http://purl.uniprot.org/uniprot/F2NQH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/869210:MARKY_RS03060 ^@ http://purl.uniprot.org/uniprot/F2NQ39 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/869210:MARKY_RS05860 ^@ http://purl.uniprot.org/uniprot/F2NPB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS08700 ^@ http://purl.uniprot.org/uniprot/F2NMT1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/869210:MARKY_RS03595 ^@ http://purl.uniprot.org/uniprot/F2NL54 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/869210:MARKY_RS04175 ^@ http://purl.uniprot.org/uniprot/F2NNY2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS05415 ^@ http://purl.uniprot.org/uniprot/F2NMD6 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/869210:MARKY_RS05570 ^@ http://purl.uniprot.org/uniprot/F2NP54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS07605 ^@ http://purl.uniprot.org/uniprot/F2NPG4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/869210:MARKY_RS03295 ^@ http://purl.uniprot.org/uniprot/F2NQ86 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS09785 ^@ http://purl.uniprot.org/uniprot/F2NKL9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/869210:MARKY_RS07025 ^@ http://purl.uniprot.org/uniprot/F2NMG3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/869210:MARKY_RS09330 ^@ http://purl.uniprot.org/uniprot/F2NR11 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/869210:MARKY_RS04645 ^@ http://purl.uniprot.org/uniprot/F2NQE2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/869210:MARKY_RS04170 ^@ http://purl.uniprot.org/uniprot/F2NNY1 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/869210:MARKY_RS01215 ^@ http://purl.uniprot.org/uniprot/F2NNI2 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/869210:MARKY_RS10845 ^@ http://purl.uniprot.org/uniprot/F2NPV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/869210:MARKY_RS03990 ^@ http://purl.uniprot.org/uniprot/F2NM66 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/869210:MARKY_RS05980 ^@ http://purl.uniprot.org/uniprot/F2NQJ7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/869210:MARKY_RS10690 ^@ http://purl.uniprot.org/uniprot/F2NPS3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/869210:MARKY_RS05660 ^@ http://purl.uniprot.org/uniprot/F2NP72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/869210:MARKY_RS03830 ^@ http://purl.uniprot.org/uniprot/F2NM34 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/869210:MARKY_RS03920 ^@ http://purl.uniprot.org/uniprot/F2NM52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/869210:MARKY_RS07390 ^@ http://purl.uniprot.org/uniprot/F2NPC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS04120 ^@ http://purl.uniprot.org/uniprot/F2NNX0 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/869210:MARKY_RS04845 ^@ http://purl.uniprot.org/uniprot/F2NL91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS00935 ^@ http://purl.uniprot.org/uniprot/F2NNA1 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/869210:MARKY_RS06990 ^@ http://purl.uniprot.org/uniprot/F2NLM7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/869210:MARKY_RS00615 ^@ http://purl.uniprot.org/uniprot/F2NLQ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell inner membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/869210:MARKY_RS01595 ^@ http://purl.uniprot.org/uniprot/F2NPW7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/869210:MARKY_RS03355 ^@ http://purl.uniprot.org/uniprot/F2NQ97 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/869210:MARKY_RS04260 ^@ http://purl.uniprot.org/uniprot/F2NP00 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/869210:MARKY_RS00530 ^@ http://purl.uniprot.org/uniprot/F2NLN4 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.|||Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/869210:MARKY_RS06690 ^@ http://purl.uniprot.org/uniprot/F2NLH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.|||Homotetramer composed of a dimer of dimers.