http://togogenome.org/gene/8022:LOC100136295 ^@ http://purl.uniprot.org/uniprot/P79823 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/8022:nachra9 ^@ http://purl.uniprot.org/uniprot/Q8JFN7 ^@ Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.|||Cell membrane|||Expressed in the liver, olfactory mucosa, pituitary gland, hair cells of the saccule and spleen.|||Postsynaptic cell membrane http://togogenome.org/gene/8022:pax7a ^@ http://purl.uniprot.org/uniprot/H9NNB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8022:LOC100135792 ^@ http://purl.uniprot.org/uniprot/Q9YGF4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:sumo-1 ^@ http://purl.uniprot.org/uniprot/Q9PT08 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Cell membrane|||Cleavage of precursor form by a sentrin-specific protease is necessary for function.|||Cytoplasm|||Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Covalently attached to a number of proteins (By similarity).|||Nucleus|||Nucleus membrane|||Nucleus speckle|||PML body|||Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. http://togogenome.org/gene/8022:vipr1b ^@ http://purl.uniprot.org/uniprot/Q64FL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:reep5 ^@ http://purl.uniprot.org/uniprot/C1BHZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/8022:tlr1 ^@ http://purl.uniprot.org/uniprot/C9EH89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8022:aptx ^@ http://purl.uniprot.org/uniprot/Q6EF50 ^@ Subcellular Location Annotation ^@ nucleolus|||nucleoplasm http://togogenome.org/gene/8022:LOC100136595 ^@ http://purl.uniprot.org/uniprot/Q76K78 ^@ Function|||Similarity ^@ Belongs to the calcitonin family.|||Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. http://togogenome.org/gene/8022:LOC100136120 ^@ http://purl.uniprot.org/uniprot/Q5NDK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol http://togogenome.org/gene/8022:adcyap1r1b ^@ http://purl.uniprot.org/uniprot/Q64FL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:manbal ^@ http://purl.uniprot.org/uniprot/C1BEJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/8022:ap2m1 ^@ http://purl.uniprot.org/uniprot/C1BFZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/8022:rl32 ^@ http://purl.uniprot.org/uniprot/C1BFT6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/8022:myod ^@ http://purl.uniprot.org/uniprot/Q91205 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/8022:LOC100135790 ^@ http://purl.uniprot.org/uniprot/Q9YGF7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:LOC100135977 ^@ http://purl.uniprot.org/uniprot/Q8QGB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8022:mrp1 ^@ http://purl.uniprot.org/uniprot/D1KF95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100135982 ^@ http://purl.uniprot.org/uniprot/Q7ZT61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/8022:KEF44_p02 ^@ http://purl.uniprot.org/uniprot/P48177|||http://purl.uniprot.org/uniprot/Q7HET1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/8022:slc39a1 ^@ http://purl.uniprot.org/uniprot/Q5QJB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:LOC100136274 ^@ http://purl.uniprot.org/uniprot/Q5EPK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:5ntc ^@ http://purl.uniprot.org/uniprot/C1BEQ6 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/8022:lbp/bpi-2 ^@ http://purl.uniprot.org/uniprot/Q8JFX3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/8022:hsp90bb ^@ http://purl.uniprot.org/uniprot/Q5DW65 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8022:c1h15orf40 ^@ http://purl.uniprot.org/uniprot/C1BHT8 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/8022:kcnn2 ^@ http://purl.uniprot.org/uniprot/Q90ZP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:dnsl3 ^@ http://purl.uniprot.org/uniprot/C1BHD9 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/8022:c8a ^@ http://purl.uniprot.org/uniprot/Q5W1L1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:rorca ^@ http://purl.uniprot.org/uniprot/E4W7U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8022:zfp313 ^@ http://purl.uniprot.org/uniprot/Q6J0M9 ^@ Subunit ^@ Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling. http://togogenome.org/gene/8022:hif1a ^@ http://purl.uniprot.org/uniprot/Q98SW2 ^@ Activity Regulation|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID) (By similarity).|||Cytoplasm|||Efficient DNA binding requires heterodimerization of an alpha and a beta/ARNT subunit.|||Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.|||In normoxia, is hydroxylated on Asn-743, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.|||In normoxia, is hydroxylated on Pro-426 and Pro-559. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity).|||Induced by reactive oxygen species (ROS).|||Nucleus|||Nucleus speckle|||The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains. http://togogenome.org/gene/8022:LOC100136780 ^@ http://purl.uniprot.org/uniprot/P45433 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Phosphorylated in its cytoplasmic tail.|||Seems to bind calcium.|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/8022:LOC100301866 ^@ http://purl.uniprot.org/uniprot/C1BGF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/8022:tnfsf13 ^@ http://purl.uniprot.org/uniprot/A5HBL5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:il17c1 ^@ http://purl.uniprot.org/uniprot/D4HTR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/8022:tyr ^@ http://purl.uniprot.org/uniprot/Q75W62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8022:txn4a ^@ http://purl.uniprot.org/uniprot/C1BFB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/8022:mrb ^@ http://purl.uniprot.org/uniprot/Q5WP01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:LOC100305179 ^@ http://purl.uniprot.org/uniprot/C1BGV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/8022:c1r ^@ http://purl.uniprot.org/uniprot/Q70W31 ^@ Caution|||Function|||Subunit ^@ C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.|||C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:vim ^@ http://purl.uniprot.org/uniprot/P48674 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intermediate filament family.|||Cytoplasm|||Homomer assembled from elementary dimers.|||Nucleus matrix|||One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.|||The central alpha-helical coiled-coil IF rod domain mediates elementary homodimerization.|||Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.|||cytoskeleton http://togogenome.org/gene/8022:ifn3 ^@ http://purl.uniprot.org/uniprot/A8E0J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/8022:pfd4 ^@ http://purl.uniprot.org/uniprot/C1BFJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/8022:KEF44_p01 ^@ http://purl.uniprot.org/uniprot/E2JDK9|||http://purl.uniprot.org/uniprot/P48173 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/8022:ar-alpha ^@ http://purl.uniprot.org/uniprot/O93244 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:igfbp6 ^@ http://purl.uniprot.org/uniprot/Q3HWG4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:gstk1 ^@ http://purl.uniprot.org/uniprot/C1BHF3 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/8022:ck073 ^@ http://purl.uniprot.org/uniprot/C1BH37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/8022:esr1 ^@ http://purl.uniprot.org/uniprot/P16058 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/8022:ciapin1 ^@ http://purl.uniprot.org/uniprot/C1BH56 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Mitochondrion intermembrane space|||Monomer. Interacts with ndor1. Interacts with chchd4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/8022:igfbp2 ^@ http://purl.uniprot.org/uniprot/Q3I344 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:il19l ^@ http://purl.uniprot.org/uniprot/D3GMR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/8022:paqr8 ^@ http://purl.uniprot.org/uniprot/Q3HW38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8022:rb1 ^@ http://purl.uniprot.org/uniprot/Q9YGE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/8022:LOC100135985 ^@ http://purl.uniprot.org/uniprot/Q7ZT58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/8022:KEF44_p08 ^@ http://purl.uniprot.org/uniprot/P48178 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:LOC100136217 ^@ http://purl.uniprot.org/uniprot/Q596C5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8022:st8sia4 ^@ http://purl.uniprot.org/uniprot/Q7T2X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8022:romo1 ^@ http://purl.uniprot.org/uniprot/C1BGC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:LOC100136637 ^@ http://purl.uniprot.org/uniprot/Q90W71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:ngb1 ^@ http://purl.uniprot.org/uniprot/P59742 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the globin family.|||Cytoplasm|||Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Capable of penetrating cell membranes (By similarity).|||Monomer.|||Perikaryon http://togogenome.org/gene/8022:rnh1 ^@ http://purl.uniprot.org/uniprot/C1BH38 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/8022:il2rb ^@ http://purl.uniprot.org/uniprot/G4RJE0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:tbx21 ^@ http://purl.uniprot.org/uniprot/E1UGZ0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:LOC100135791 ^@ http://purl.uniprot.org/uniprot/Q9YGF5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:ralb ^@ http://purl.uniprot.org/uniprot/C1BGW3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8022:myc ^@ http://purl.uniprot.org/uniprot/Q2L4Q4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. http://togogenome.org/gene/8022:fshb ^@ http://purl.uniprot.org/uniprot/Q9DG93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/8022:LOC100335037 ^@ http://purl.uniprot.org/uniprot/O13085 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:comtd1 ^@ http://purl.uniprot.org/uniprot/C1BFU4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/8022:dad1 ^@ http://purl.uniprot.org/uniprot/C1BF63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/8022:hsd11b2 ^@ http://purl.uniprot.org/uniprot/Q7SZK9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8022:LOC100135869 ^@ http://purl.uniprot.org/uniprot/C1BIE5|||http://purl.uniprot.org/uniprot/O73817 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/8022:rl17 ^@ http://purl.uniprot.org/uniprot/C1BF83 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/8022:LOC100136070 ^@ http://purl.uniprot.org/uniprot/Q8AWA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/8022:irf1b ^@ http://purl.uniprot.org/uniprot/Q8JIC9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:slc5a2 ^@ http://purl.uniprot.org/uniprot/Q2A661 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8022:e3 ^@ http://purl.uniprot.org/uniprot/Q8JFG4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8022:myd88 ^@ http://purl.uniprot.org/uniprot/Q4LBC6 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm|||The intermediate domain (ID) is required for the phosphorylation and activation of IRAK. http://togogenome.org/gene/8022:ambp ^@ http://purl.uniprot.org/uniprot/Q5F4T3 ^@ Similarity|||Subcellular Location Annotation ^@ In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/8022:ift46 ^@ http://purl.uniprot.org/uniprot/C1BGP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/8022:ifn5 ^@ http://purl.uniprot.org/uniprot/C1L350 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/8022:p24b ^@ http://purl.uniprot.org/uniprot/Q2L4Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8022:ghitm ^@ http://purl.uniprot.org/uniprot/Q1M195 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8022:il-17a ^@ http://purl.uniprot.org/uniprot/Q70I21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/8022:LOC100136321 ^@ http://purl.uniprot.org/uniprot/Q2I7F2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:leap-2b ^@ http://purl.uniprot.org/uniprot/Q64JE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/8022:hce23 ^@ http://purl.uniprot.org/uniprot/C1BH58 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:htatsf1 ^@ http://purl.uniprot.org/uniprot/O73631 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HTATSF1 family.|||Nucleus http://togogenome.org/gene/8022:il15 ^@ http://purl.uniprot.org/uniprot/Q575Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/8022:mb ^@ http://purl.uniprot.org/uniprot/D0FZZ1 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/8022:hsf1a ^@ http://purl.uniprot.org/uniprot/Q76M54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/8022:lamtor3 ^@ http://purl.uniprot.org/uniprot/C1BGB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/8022:sumo1 ^@ http://purl.uniprot.org/uniprot/C1BFB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/8022:cd40 ^@ http://purl.uniprot.org/uniprot/I1SKZ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:mapip ^@ http://purl.uniprot.org/uniprot/C1BFT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/8022:lhb ^@ http://purl.uniprot.org/uniprot/Q9DG92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/8022:casp9 ^@ http://purl.uniprot.org/uniprot/Q1AP00 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8022:wnt4a1 ^@ http://purl.uniprot.org/uniprot/G9DAQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8022:apoa-i-2 ^@ http://purl.uniprot.org/uniprot/A0A060W2S2|||http://purl.uniprot.org/uniprot/O57524 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein A1/A4/E family.|||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).|||Secreted http://togogenome.org/gene/8022:trub2 ^@ http://purl.uniprot.org/uniprot/C1BEU4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/8022:il17d ^@ http://purl.uniprot.org/uniprot/Q70I20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/8022:igfbp1 ^@ http://purl.uniprot.org/uniprot/Q3HWG3 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:fabph ^@ http://purl.uniprot.org/uniprot/C1BH46 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8022:p2ry2 ^@ http://purl.uniprot.org/uniprot/C1BHK5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:hint2 ^@ http://purl.uniprot.org/uniprot/C1BG47 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/8022:dhdds ^@ http://purl.uniprot.org/uniprot/B6ETP4 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/8022:LOC100136700 ^@ http://purl.uniprot.org/uniprot/A9XEM9 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/8022:trpc1 ^@ http://purl.uniprot.org/uniprot/D7NVX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/8022:nkx2.1b ^@ http://purl.uniprot.org/uniprot/Q58A08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:ndufa1 ^@ http://purl.uniprot.org/uniprot/C1BG57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:LOC100136949 ^@ http://purl.uniprot.org/uniprot/Q8AXU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:cmc2 ^@ http://purl.uniprot.org/uniprot/C1BES8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/8022:c7b ^@ http://purl.uniprot.org/uniprot/Q7T2W9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:vig1 ^@ http://purl.uniprot.org/uniprot/O93384 ^@ Cofactor|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||By interferon type I, type II and LPS. Induced by infection with viral hemorrhagic septicemia virus (VHSV), presumably through type I interferon pathway.|||Endoplasmic reticulum membrane|||Expressed at low levels in spleen and head kidney.|||Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. http://togogenome.org/gene/8022:LOC100301728 ^@ http://purl.uniprot.org/uniprot/C1BEY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/8022:jun ^@ http://purl.uniprot.org/uniprot/Q2L4Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/8022:rhd ^@ http://purl.uniprot.org/uniprot/A8QJT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8022:si:dkey-51e6.1 ^@ http://purl.uniprot.org/uniprot/C1BGM8 ^@ Similarity ^@ Belongs to the janus family. http://togogenome.org/gene/8022:tspo ^@ http://purl.uniprot.org/uniprot/Q7ZZV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/8022:plp ^@ http://purl.uniprot.org/uniprot/P79826 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the myelin proteolipid protein family.|||Cell membrane|||Central nervous system. Highest levels in spinal cord and medulla oblongata.|||First expressed at hatching day, levels rapidly increase during the early postnatal period reaching a maximum by the 9th week. High levels are maintained in adults.|||This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. May be involved in neuron and glial cell differentiation. http://togogenome.org/gene/8022:LOC100136775 ^@ http://purl.uniprot.org/uniprot/P79899 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:si:dkey-42i9.4 ^@ http://purl.uniprot.org/uniprot/C1BEQ4 ^@ Function|||Similarity ^@ Anti-proliferative protein.|||Belongs to the BTG family. http://togogenome.org/gene/8022:LOC100136175 ^@ http://purl.uniprot.org/uniprot/Q6X4M3 ^@ Developmental Stage|||Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the lin-52 family.|||Component of the DREAM complex.|||Down-regulated in the retina at smoltification, the metamorphic transformation from a parr to a molt.|||Expressed in the brain, liver and retina. Highly expressed in the retinal ganglion cell and inner nuclear layers at the parr stage. Expressed at a lower level in inner segments of some retinal photoreceptors.|||May be involved in retinal development. http://togogenome.org/gene/8022:hba1 ^@ http://purl.uniprot.org/uniprot/Q98974 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:defbl3 ^@ http://purl.uniprot.org/uniprot/C9WX69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/8022:LOC100135983 ^@ http://purl.uniprot.org/uniprot/Q7ZT60 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/8022:catl ^@ http://purl.uniprot.org/uniprot/C1BH60 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8022:LOC100136077 ^@ http://purl.uniprot.org/uniprot/Q5NKF9 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/8022:sstr1b ^@ http://purl.uniprot.org/uniprot/Q5G547 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:nudt1 ^@ http://purl.uniprot.org/uniprot/C1BHM9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/8022:il10 ^@ http://purl.uniprot.org/uniprot/Q6L8N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/8022:atp6v0cb ^@ http://purl.uniprot.org/uniprot/C1BFU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/8022:mrpl2 ^@ http://purl.uniprot.org/uniprot/C1BHW7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/8022:mcts1 ^@ http://purl.uniprot.org/uniprot/C1BFA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/8022:csn5 ^@ http://purl.uniprot.org/uniprot/C1BF76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/8022:defbl1 ^@ http://purl.uniprot.org/uniprot/Q14QQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/8022:gbrap ^@ http://purl.uniprot.org/uniprot/C1BFZ4 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8022:LOC100136752 ^@ http://purl.uniprot.org/uniprot/Q91195 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Cysteine proteinase inhibitor.|||Secreted http://togogenome.org/gene/8022:rl15 ^@ http://purl.uniprot.org/uniprot/C1BFS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/8022:imp4 ^@ http://purl.uniprot.org/uniprot/C1BH39 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8022:LOC100136345 ^@ http://purl.uniprot.org/uniprot/A0SML0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8022:LOC100135999 ^@ http://purl.uniprot.org/uniprot/Q8QGB0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8022:LOC100136729 ^@ http://purl.uniprot.org/uniprot/P49253 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family.|||Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).|||Mitochondrion outer membrane http://togogenome.org/gene/8022:ube2n ^@ http://purl.uniprot.org/uniprot/C1BFZ2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8022:akirin2 ^@ http://purl.uniprot.org/uniprot/C8BMC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:LOC100301741 ^@ http://purl.uniprot.org/uniprot/C1BF34 ^@ Similarity ^@ Belongs to the PNP/MTAP phosphorylase family. http://togogenome.org/gene/8022:actr6 ^@ http://purl.uniprot.org/uniprot/C1BGF8 ^@ Similarity ^@ Belongs to the actin family. ARP6 subfamily. http://togogenome.org/gene/8022:iscua ^@ http://purl.uniprot.org/uniprot/D1J6Y1 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/8022:plg ^@ http://purl.uniprot.org/uniprot/Q5DVP8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/8022:pob ^@ http://purl.uniprot.org/uniprot/C1BET9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/8022:med31 ^@ http://purl.uniprot.org/uniprot/C1BFD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8022:LOC100170213 ^@ http://purl.uniprot.org/uniprot/A0A060XQP6 ^@ Domain|||Function|||Subcellular Location Annotation|||Tissue Specificity ^@ Calcium-binding component of otoliths, a calcium carbonate structure of the inner ear involved in hearing and balance sensing (PubMed:18410381). Binds calcium (PubMed:18410381, PubMed:28866388).|||Specifically expressed in otolith matrix-producing cells.|||The Asp/Glu-rich (acidic) region mediates binding to calcium.|||extracellular matrix http://togogenome.org/gene/8022:LOC100653482 ^@ http://purl.uniprot.org/uniprot/F4NAR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:LOC100136672 ^@ http://purl.uniprot.org/uniprot/Q5G546 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:cd8a ^@ http://purl.uniprot.org/uniprot/Q9IAL5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:il21 ^@ http://purl.uniprot.org/uniprot/E4W7U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/8022:cbs ^@ http://purl.uniprot.org/uniprot/A9Z023 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/8022:c6 ^@ http://purl.uniprot.org/uniprot/Q6H964 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:LOC100136196 ^@ http://purl.uniprot.org/uniprot/Q6UFZ5 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8022:abcg2 ^@ http://purl.uniprot.org/uniprot/A8IJF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/8022:nramp-alpha ^@ http://purl.uniprot.org/uniprot/Q9W665 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/8022:ndufb1 ^@ http://purl.uniprot.org/uniprot/C1BGW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:igfbp5 ^@ http://purl.uniprot.org/uniprot/Q3HNB1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:LOC100499584 ^@ http://purl.uniprot.org/uniprot/C8BMC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:p22-phox ^@ http://purl.uniprot.org/uniprot/Q60FB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/8022:LOC100379112 ^@ http://purl.uniprot.org/uniprot/A5X2V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/8022:il2 ^@ http://purl.uniprot.org/uniprot/C7AL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/8022:emp2 ^@ http://purl.uniprot.org/uniprot/C1BI46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/8022:LOC100499589 ^@ http://purl.uniprot.org/uniprot/C8BMC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:LOC100135781 ^@ http://purl.uniprot.org/uniprot/O57395 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:c8b ^@ http://purl.uniprot.org/uniprot/Q90X85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).|||Secreted http://togogenome.org/gene/8022:c-myc ^@ http://purl.uniprot.org/uniprot/Q91421 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. http://togogenome.org/gene/8022:cxcl12a ^@ http://purl.uniprot.org/uniprot/H1ZZ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8022:psd6 ^@ http://purl.uniprot.org/uniprot/C1BGB4 ^@ Similarity ^@ Belongs to the proteasome subunit S10 family. http://togogenome.org/gene/8022:tnfr ^@ http://purl.uniprot.org/uniprot/Q7T2H3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:krt79 ^@ http://purl.uniprot.org/uniprot/Q91219 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8022:LOC100135837 ^@ http://purl.uniprot.org/uniprot/Q5R1Y9 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8022:KEF44_p03 ^@ http://purl.uniprot.org/uniprot/P48176 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/8022:taf10 ^@ http://purl.uniprot.org/uniprot/C1BGY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus http://togogenome.org/gene/8022:LOC100136697 ^@ http://purl.uniprot.org/uniprot/A0T073 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/8022:KEF44_p13 ^@ http://purl.uniprot.org/uniprot/P48174 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/8022:LOC100136751 ^@ http://purl.uniprot.org/uniprot/Q91194 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted|||Somatostatin inhibits the release of somatotropin. http://togogenome.org/gene/8022:LOC100301659 ^@ http://purl.uniprot.org/uniprot/B8YMU0 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/8022:LOC100135808 ^@ http://purl.uniprot.org/uniprot/Q9DG94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/8022:lyrm2 ^@ http://purl.uniprot.org/uniprot/C1BG03 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/8022:cct8 ^@ http://purl.uniprot.org/uniprot/Q5DW61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/8022:hus1 ^@ http://purl.uniprot.org/uniprot/C1BF59 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/8022:gsto1 ^@ http://purl.uniprot.org/uniprot/C1BFM5 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/8022:vatg1 ^@ http://purl.uniprot.org/uniprot/C1BHX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8022:nr1i2 ^@ http://purl.uniprot.org/uniprot/A5A0Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8022:tnf ^@ http://purl.uniprot.org/uniprot/Q9DEP9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:LOC100135963 ^@ http://purl.uniprot.org/uniprot/Q804Y0 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/8022:LOC100136674 ^@ http://purl.uniprot.org/uniprot/Q49BZ2 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/8022:wt-t1a ^@ http://purl.uniprot.org/uniprot/Q90XX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/8022:yee9 ^@ http://purl.uniprot.org/uniprot/C1BEK3 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/8022:mstnb ^@ http://purl.uniprot.org/uniprot/Q90ZD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/8022:rl23 ^@ http://purl.uniprot.org/uniprot/C1BF21 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/8022:LOC100301812 ^@ http://purl.uniprot.org/uniprot/C1BFU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/8022:stat1-2 ^@ http://purl.uniprot.org/uniprot/O13132 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:LOC100135908 ^@ http://purl.uniprot.org/uniprot/Q98T97 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/8022:il17r ^@ http://purl.uniprot.org/uniprot/A1IMH6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:cxcl13 ^@ http://purl.uniprot.org/uniprot/H1ZZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8022:cathy ^@ http://purl.uniprot.org/uniprot/Q64HX9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8022:ywhaqa ^@ http://purl.uniprot.org/uniprot/Q6UFZ7 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8022:nduba ^@ http://purl.uniprot.org/uniprot/C1BFI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:LOC100136027 ^@ http://purl.uniprot.org/uniprot/Q9DEQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/8022:sodc ^@ http://purl.uniprot.org/uniprot/C1BFL3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/8022:tmco1 ^@ http://purl.uniprot.org/uniprot/C1BG63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:nipsnap2 ^@ http://purl.uniprot.org/uniprot/C1BFD5 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/8022:inh ^@ http://purl.uniprot.org/uniprot/Q9DED3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/8022:if3c ^@ http://purl.uniprot.org/uniprot/C1BG32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:fa36a ^@ http://purl.uniprot.org/uniprot/C1BGQ1 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/8022:tsn9 ^@ http://purl.uniprot.org/uniprot/C1BGT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8022:c4bp ^@ http://purl.uniprot.org/uniprot/C1BGN0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:rl11 ^@ http://purl.uniprot.org/uniprot/C1BHT3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/8022:LOC100135863 ^@ http://purl.uniprot.org/uniprot/O42259 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).|||Homotetramer.|||Nucleus|||S-nitrosylation of Cys-152 leads to translocation to the nucleus.|||cytoskeleton|||cytosol http://togogenome.org/gene/8022:LOC110520024 ^@ http://purl.uniprot.org/uniprot/O42445 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/8022:d2r1 ^@ http://purl.uniprot.org/uniprot/Q90WQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:calr3a ^@ http://purl.uniprot.org/uniprot/Q6UD79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8022:mx ^@ http://purl.uniprot.org/uniprot/Q91192 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.|||Cytoplasm|||Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV). http://togogenome.org/gene/8022:gp91phox ^@ http://purl.uniprot.org/uniprot/Q60FB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:rpl9 ^@ http://purl.uniprot.org/uniprot/C1BEP9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/8022:rs4x ^@ http://purl.uniprot.org/uniprot/C1BFS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/8022:LOC100135986 ^@ http://purl.uniprot.org/uniprot/Q8AYJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/8022:LOC100136245 ^@ http://purl.uniprot.org/uniprot/Q64HW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin L subfamily.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/8022:sys1 ^@ http://purl.uniprot.org/uniprot/C1BFK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/8022:gh1 ^@ http://purl.uniprot.org/uniprot/P09538 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.|||Secreted http://togogenome.org/gene/8022:LOC100136761 ^@ http://purl.uniprot.org/uniprot/P87370 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome http://togogenome.org/gene/8022:lep ^@ http://purl.uniprot.org/uniprot/B0M1K7 ^@ Similarity ^@ Belongs to the leptin family. http://togogenome.org/gene/8022:zp2.3 ^@ http://purl.uniprot.org/uniprot/Q9I9M7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:LOC100135882 ^@ http://purl.uniprot.org/uniprot/Q9W6B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8022:tmek ^@ http://purl.uniprot.org/uniprot/Q53HX4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8022:cyp2k4 ^@ http://purl.uniprot.org/uniprot/O93297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/8022:serping1 ^@ http://purl.uniprot.org/uniprot/Q70W32 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8022:iscub ^@ http://purl.uniprot.org/uniprot/H6SG24 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/8022:irf3 ^@ http://purl.uniprot.org/uniprot/F9UKT9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:if5 ^@ http://purl.uniprot.org/uniprot/C1BFP9 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/8022:ctsc ^@ http://purl.uniprot.org/uniprot/Q64HY0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8022:cacna1b ^@ http://purl.uniprot.org/uniprot/Q7T1M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. http://togogenome.org/gene/8022:if4ea ^@ http://purl.uniprot.org/uniprot/C1BFN1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/8022:otomp ^@ http://purl.uniprot.org/uniprot/Q9IBF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the transferrin family.|||Expressed in the sacculus during the day.|||Interacts with OTOL1.|||Required for normal otolith growth and deposition of otolin-1 in the otolith.|||Secreted http://togogenome.org/gene/8022:si:dkey-251i10.1 ^@ http://purl.uniprot.org/uniprot/B9VQA5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/8022:LOC100136156 ^@ http://purl.uniprot.org/uniprot/Q8JFN5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:rpb7 ^@ http://purl.uniprot.org/uniprot/C1BIG7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||Nucleus http://togogenome.org/gene/8022:LOC100136290 ^@ http://purl.uniprot.org/uniprot/Q91215 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:hn1 ^@ http://purl.uniprot.org/uniprot/C1BEH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:LOC100301636 ^@ http://purl.uniprot.org/uniprot/B5AXN7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/8022:rbtstat3 ^@ http://purl.uniprot.org/uniprot/O13133 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:capn2 ^@ http://purl.uniprot.org/uniprot/Q672G9 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8022:4ebp2 ^@ http://purl.uniprot.org/uniprot/C1BHL7 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/8022:ndufa8 ^@ http://purl.uniprot.org/uniprot/C1BF81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/8022:pm14 ^@ http://purl.uniprot.org/uniprot/C1BEN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:il1rl1 ^@ http://purl.uniprot.org/uniprot/M1ZJW4 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/8022:LOC100499582 ^@ http://purl.uniprot.org/uniprot/C7S8F2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8022:LOC100136004 ^@ http://purl.uniprot.org/uniprot/Q8QFP0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/8022:LOC100136162 ^@ http://purl.uniprot.org/uniprot/Q6YLY1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/8022:yt6j ^@ http://purl.uniprot.org/uniprot/C1BFY2 ^@ Cofactor|||Similarity ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/8022:LOC101268919 ^@ http://purl.uniprot.org/uniprot/G9B9Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:LOC100305204 ^@ http://purl.uniprot.org/uniprot/C1BH52 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/8022:wt-t1b ^@ http://purl.uniprot.org/uniprot/Q90XX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/8022:LOC100136741 ^@ http://purl.uniprot.org/uniprot/Q02815 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. http://togogenome.org/gene/8022:LOC100136317 ^@ http://purl.uniprot.org/uniprot/Q2I7F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane|||Secreted http://togogenome.org/gene/8022:LOC100329196 ^@ http://purl.uniprot.org/uniprot/D0R0G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/8022:gnpi ^@ http://purl.uniprot.org/uniprot/C1BI75 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/8022:n4wbp5 ^@ http://purl.uniprot.org/uniprot/Q5F4T2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:ucp2b ^@ http://purl.uniprot.org/uniprot/Q2PXW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8022:gcg2 ^@ http://purl.uniprot.org/uniprot/Q91189 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.|||Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.|||Secreted http://togogenome.org/gene/8022:LOC100136065 ^@ http://purl.uniprot.org/uniprot/Q90W12 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||clathrin-coated pit http://togogenome.org/gene/8022:serpinf2 ^@ http://purl.uniprot.org/uniprot/D9UB76 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8022:ywhah ^@ http://purl.uniprot.org/uniprot/Q6UFZ0 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8022:gtf2h5 ^@ http://purl.uniprot.org/uniprot/C1BEZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/8022:mmp ^@ http://purl.uniprot.org/uniprot/Q9DEE0 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/8022:cygb ^@ http://purl.uniprot.org/uniprot/Q802S6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:bet1l ^@ http://purl.uniprot.org/uniprot/C1BGE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:nell2b ^@ http://purl.uniprot.org/uniprot/C5JA74 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:tpt1 ^@ http://purl.uniprot.org/uniprot/E7BBH8 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/8022:shbgb ^@ http://purl.uniprot.org/uniprot/A5JUT5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:sf3b5 ^@ http://purl.uniprot.org/uniprot/C1BFG0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/8022:LOC100499585 ^@ http://purl.uniprot.org/uniprot/C8BMC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:e1 ^@ http://purl.uniprot.org/uniprot/Q90W76 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8022:LOC100135953 ^@ http://purl.uniprot.org/uniprot/Q98TT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/8022:ifn2 ^@ http://purl.uniprot.org/uniprot/Q70G08 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8022:ru1c ^@ http://purl.uniprot.org/uniprot/C1BGQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/8022:cf166 ^@ http://purl.uniprot.org/uniprot/C1BI08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:LOC100305255 ^@ http://purl.uniprot.org/uniprot/C1BHQ9 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/8022:slc9a2 ^@ http://purl.uniprot.org/uniprot/A4GWV1 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/8022:rl21 ^@ http://purl.uniprot.org/uniprot/C1BFU1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/8022:LOC100301637 ^@ http://purl.uniprot.org/uniprot/B5AYD7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/8022:pparab ^@ http://purl.uniprot.org/uniprot/E2IH97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8022:gemin2 ^@ http://purl.uniprot.org/uniprot/C1BFX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. http://togogenome.org/gene/8022:prlra ^@ http://purl.uniprot.org/uniprot/Q9DE08 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/8022:LOC100136147 ^@ http://purl.uniprot.org/uniprot/A7WNH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/8022:shbg ^@ http://purl.uniprot.org/uniprot/Q2WFI5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:mtnr1aa ^@ http://purl.uniprot.org/uniprot/Q9PT20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/8022:epd ^@ http://purl.uniprot.org/uniprot/P28770 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the ependymin family.|||Binds calcium through the terminal sialic acids.|||EPDs are synthesized in the meninx and secreted in the cerebrospinal fluid.|||May play a role in neural plasticity. May be involved during axon regeneration.|||Secreted http://togogenome.org/gene/8022:rs5 ^@ http://purl.uniprot.org/uniprot/C1BEL7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/8022:LOC100136257 ^@ http://purl.uniprot.org/uniprot/Q1M160 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. http://togogenome.org/gene/8022:nr1h3 ^@ http://purl.uniprot.org/uniprot/B8Y3M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8022:tnf-alpha ^@ http://purl.uniprot.org/uniprot/Q9I976 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:canb1 ^@ http://purl.uniprot.org/uniprot/C1BF28 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/8022:pparb ^@ http://purl.uniprot.org/uniprot/E2IH98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8022:LOC100135818 ^@ http://purl.uniprot.org/uniprot/Q805B7 ^@ Function|||Similarity ^@ Belongs to the calcitonin family.|||Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. http://togogenome.org/gene/8022:cnp-1-2 ^@ http://purl.uniprot.org/uniprot/Q8AXR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the natriuretic peptide family.|||Exhibits natriuretic and vasodepressor activity. Has a cGMP-stimulating activity (By similarity).|||Expressed in brain and to a low extent in atrium.|||Secreted http://togogenome.org/gene/8022:adcyap1 ^@ http://purl.uniprot.org/uniprot/Q98SP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/8022:ndufc2 ^@ http://purl.uniprot.org/uniprot/C1BGY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:smad3 ^@ http://purl.uniprot.org/uniprot/C1BH24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:LOC100136621 ^@ http://purl.uniprot.org/uniprot/A0A060YDJ7|||http://purl.uniprot.org/uniprot/Q98SN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.|||Membrane|||Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in pronephric kidney tubule development (By similarity). http://togogenome.org/gene/8022:eif3m ^@ http://purl.uniprot.org/uniprot/C1BH36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8022:rl7 ^@ http://purl.uniprot.org/uniprot/C1BHP6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/8022:ywhaba ^@ http://purl.uniprot.org/uniprot/A0A060XH76|||http://purl.uniprot.org/uniprot/Q6UFZ9 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).|||Belongs to the 14-3-3 family.|||Cytoplasm|||Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skin, spleen and testis.|||Expressed throughout development. Expressed in the neural crest, eyes, yolk syncytium, tail bud and caudal somites of somitic embryos. Expressed in the neural crest, gill covers and gill arches, and the pectoral fins of post-somitic embryos.|||Homodimer, and heterodimer with other family members.|||Repressed under stress conditions such as netting. http://togogenome.org/gene/8022:zgc:112271 ^@ http://purl.uniprot.org/uniprot/C1BEL3 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/8022:thg1l ^@ http://purl.uniprot.org/uniprot/C1BI96 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/8022:k13 ^@ http://purl.uniprot.org/uniprot/Q8JFQ6 ^@ Function|||Miscellaneous|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the intermediate filament family.|||Expressed in epidermis.|||Heterotetramer of two type I and two type II keratins.|||There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).|||Type 1 keratin (Probable). May maintain oral mucosal cell homeostasis and tissue organization in response to mechanical stress (By similarity). http://togogenome.org/gene/8022:tmm85 ^@ http://purl.uniprot.org/uniprot/C1BEW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:ccka ^@ http://purl.uniprot.org/uniprot/Q9YGE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/8022:cd28 ^@ http://purl.uniprot.org/uniprot/Q5EPK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:fshr ^@ http://purl.uniprot.org/uniprot/Q71MM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/8022:LOC100305168 ^@ http://purl.uniprot.org/uniprot/C1BGS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/8022:glud1 ^@ http://purl.uniprot.org/uniprot/Q8JHY1 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/8022:cyp17a1 ^@ http://purl.uniprot.org/uniprot/P30437 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.|||Membrane|||Regulated predominantly by intracellular cAMP levels. http://togogenome.org/gene/8022:rs13 ^@ http://purl.uniprot.org/uniprot/C1BG76 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/8022:rtnanos3 ^@ http://purl.uniprot.org/uniprot/M1V8T8 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/8022:LOC100136727 ^@ http://purl.uniprot.org/uniprot/P12027 ^@ Function|||Miscellaneous|||PTM|||Tissue Specificity ^@ Cortical alveoli of immature ovaries.|||In response to egg activation, PSGP is discharged by exocytosis into the perivitelline space, where it undergoes rapid proteolysis into glycotridecapeptides. During fertilization and/or early development the glycotridecapeptides prevent polyspermy or are involved in the formation of a fertilization membrane.|||Most sialic acid residues exist in the form of polysialyl groups partly capped with deaminoneuraminic acid.|||Multiple genes for PSGP are transcribed into multiple mRNAs containing diverged numbers of repeating units.|||The core of the PSGP protein contains an average of 25 exact tandem repeats of the same glycotridecapeptide, where the Ser and the Thr residues are attachment sites of a polysialylglycan chain. http://togogenome.org/gene/8022:ncx ^@ http://purl.uniprot.org/uniprot/Q9PT19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:nme4 ^@ http://purl.uniprot.org/uniprot/C0KIP7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/8022:polr3k ^@ http://purl.uniprot.org/uniprot/C1BEQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/8022:tebp ^@ http://purl.uniprot.org/uniprot/Q5UTE8 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/8022:if36 ^@ http://purl.uniprot.org/uniprot/C1BGN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:pnpo ^@ http://purl.uniprot.org/uniprot/C1BH17 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/8022:gnrh3 ^@ http://purl.uniprot.org/uniprot/Q90VY3|||http://purl.uniprot.org/uniprot/Q90W09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins. http://togogenome.org/gene/8022:LOC100642186 ^@ http://purl.uniprot.org/uniprot/F9W2Z4 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.|||tight junction http://togogenome.org/gene/8022:rbhce1 ^@ http://purl.uniprot.org/uniprot/D2YYG2 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:star ^@ http://purl.uniprot.org/uniprot/A0A060WBZ2|||http://purl.uniprot.org/uniprot/Q9DEB4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/8022:cuta ^@ http://purl.uniprot.org/uniprot/C1BHH7 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/8022:crf-bp ^@ http://purl.uniprot.org/uniprot/Q5J878 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/8022:cd3e ^@ http://purl.uniprot.org/uniprot/D0VFH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:LOC100136197 ^@ http://purl.uniprot.org/uniprot/Q6UFZ4 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8022:LOC100136153 ^@ http://purl.uniprot.org/uniprot/Q8UUY8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).|||Cell membrane|||Highly expressed in the liver and red and white muscle, with lower levels of expression in the gills, heart, kidney and spleen.|||Lacks the regulatory protein kinase A phosphorylation sites within the G-protein binding domain that mediate desensitization and are present in mammalian homologs. http://togogenome.org/gene/8022:ghrl ^@ http://purl.uniprot.org/uniprot/Q76IQ4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the motilin family.|||Ghrelin-20 and Ghrelin-23 are amidated. In some cases, Gly-50 is retained after dibasic amino acid cleavage, to produce non-amidated Ghrelin-21 and Ghrelin-24.|||Highest levels in the stomach. Moderate levels in the brain, hypothalamus and intestinal tracts.|||Ligand for growth hormone secretagogue receptor type 1 (GHSR). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). Induces the release of growth hormone from the pituitary.|||O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation or O-decanoylation is essential for activity. The O-decanoylated forms differ in the length of the carbon backbone of the carboxylic acid forming an ester bond with Ser-29 (By similarity). The majority of trout ghrelin is Ghrelin-20 modified with unsaturated decanoic acid (PubMed:12970156).|||Secreted http://togogenome.org/gene/8022:cpt1 ^@ http://purl.uniprot.org/uniprot/Q8AYL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8022:tcf7 ^@ http://purl.uniprot.org/uniprot/G8GVE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/8022:rpl7l1 ^@ http://purl.uniprot.org/uniprot/C1BG77 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/8022:srp19 ^@ http://purl.uniprot.org/uniprot/C1BI41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/8022:m17 ^@ http://purl.uniprot.org/uniprot/D0R0G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/8022:gs02 ^@ http://purl.uniprot.org/uniprot/Q8JI33 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8022:opn1sw2 ^@ http://purl.uniprot.org/uniprot/Q7ZT59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/8022:capn1 ^@ http://purl.uniprot.org/uniprot/Q672H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/8022:cmas ^@ http://purl.uniprot.org/uniprot/Q90WG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid.|||Expressed in testis, ovary and liver.|||Homotetramer; the active enzyme is formed by a dimer of dimers.|||Nucleus http://togogenome.org/gene/8022:apooa ^@ http://purl.uniprot.org/uniprot/C1BH23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:ndufb7 ^@ http://purl.uniprot.org/uniprot/C1BGK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/8022:tp53 ^@ http://purl.uniprot.org/uniprot/P25035 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:rpb10 ^@ http://purl.uniprot.org/uniprot/C1BGM1 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/8022:ruxf ^@ http://purl.uniprot.org/uniprot/C1BEZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/8022:cebpb ^@ http://purl.uniprot.org/uniprot/Q7SZH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/8022:cyp1b1 ^@ http://purl.uniprot.org/uniprot/D3XFH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/8022:rhgb ^@ http://purl.uniprot.org/uniprot/A8QJ79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8022:rbp2 ^@ http://purl.uniprot.org/uniprot/Q71B03 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8022:ca4 ^@ http://purl.uniprot.org/uniprot/Q6R4A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-carbonic anhydrase family.|||Cell membrane|||Interacts with SLC4A4.|||Membrane|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8022:ntf2 ^@ http://purl.uniprot.org/uniprot/C1BI16 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/8022:srp09 ^@ http://purl.uniprot.org/uniprot/C1BFM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/8022:s1 ^@ http://purl.uniprot.org/uniprot/Q90YH3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8022:sat1 ^@ http://purl.uniprot.org/uniprot/C1BF43 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family.|||Homodimer. http://togogenome.org/gene/8022:arf4 ^@ http://purl.uniprot.org/uniprot/C1BFL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8022:mrps33 ^@ http://purl.uniprot.org/uniprot/Q6BDB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/8022:c9 ^@ http://purl.uniprot.org/uniprot/Q4QZ25 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted|||Target cell membrane http://togogenome.org/gene/8022:gng12a ^@ http://purl.uniprot.org/uniprot/C1BIC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8022:hba4 ^@ http://purl.uniprot.org/uniprot/C1BF11 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:hbb1 ^@ http://purl.uniprot.org/uniprot/C1BEX8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:nhe3b ^@ http://purl.uniprot.org/uniprot/B6VDZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Membrane http://togogenome.org/gene/8022:tyrobp ^@ http://purl.uniprot.org/uniprot/E7FKX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAP10 family.|||Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:casp8 ^@ http://purl.uniprot.org/uniprot/G8BLB6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8022:rs19 ^@ http://purl.uniprot.org/uniprot/C1BEI6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/8022:hcn2 ^@ http://purl.uniprot.org/uniprot/A8E2S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:cd34a ^@ http://purl.uniprot.org/uniprot/H1ZRI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:cd63 ^@ http://purl.uniprot.org/uniprot/Q64HX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/8022:arpc3 ^@ http://purl.uniprot.org/uniprot/C1BFF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/8022:LOC100136244 ^@ http://purl.uniprot.org/uniprot/Q64HW8 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/8022:LOC100136215 ^@ http://purl.uniprot.org/uniprot/Q6R5C2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.|||Membrane http://togogenome.org/gene/8022:LOC100305231 ^@ http://purl.uniprot.org/uniprot/C1BHG3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8022:pla2g12a ^@ http://purl.uniprot.org/uniprot/C1BFP2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8022:abracl ^@ http://purl.uniprot.org/uniprot/C1BEZ5 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/8022:fa18b ^@ http://purl.uniprot.org/uniprot/C1BF85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/8022:itpa ^@ http://purl.uniprot.org/uniprot/C1BEV3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/8022:dpm3 ^@ http://purl.uniprot.org/uniprot/C1BHD2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/8022:tcbp2 ^@ http://purl.uniprot.org/uniprot/L0R4B0 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:nr5a2 ^@ http://purl.uniprot.org/uniprot/Q2PGF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/8022:tcp4 ^@ http://purl.uniprot.org/uniprot/C1BG53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Nucleus http://togogenome.org/gene/8022:cck-n ^@ http://purl.uniprot.org/uniprot/O93606 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/8022:actriib ^@ http://purl.uniprot.org/uniprot/D9IG62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/8022:LOC100136183 ^@ http://purl.uniprot.org/uniprot/Q6VYM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8022:cd18 ^@ http://purl.uniprot.org/uniprot/A0ZXZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/8022:rtst6galnac ^@ http://purl.uniprot.org/uniprot/Q7T2X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8022:rho ^@ http://purl.uniprot.org/uniprot/Q7ZT62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/8022:ntl ^@ http://purl.uniprot.org/uniprot/C6KJ78 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:il8r ^@ http://purl.uniprot.org/uniprot/Q90ZZ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:LOC101268929 ^@ http://purl.uniprot.org/uniprot/G9C072 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8022:cpsf5 ^@ http://purl.uniprot.org/uniprot/C1BGE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/8022:calcb ^@ http://purl.uniprot.org/uniprot/Q805B6 ^@ Function|||Similarity ^@ Belongs to the calcitonin family.|||Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. http://togogenome.org/gene/8022:gs01 ^@ http://purl.uniprot.org/uniprot/Q8JI34 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8022:adipor1a ^@ http://purl.uniprot.org/uniprot/G9C071 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8022:cyp1a3 ^@ http://purl.uniprot.org/uniprot/Q9PRH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/8022:chmp3 ^@ http://purl.uniprot.org/uniprot/C1BGP2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8022:gk ^@ http://purl.uniprot.org/uniprot/O93314 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/8022:LOC100136692 ^@ http://purl.uniprot.org/uniprot/Q09IZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8022:LOC100305228 ^@ http://purl.uniprot.org/uniprot/C1BHF2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/8022:ifng ^@ http://purl.uniprot.org/uniprot/Q5QSL2 ^@ Similarity ^@ Belongs to the type II (or gamma) interferon family. http://togogenome.org/gene/8022:psb4 ^@ http://purl.uniprot.org/uniprot/C1BGS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/8022:dss1 ^@ http://purl.uniprot.org/uniprot/C1BEV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/8022:hsf1 ^@ http://purl.uniprot.org/uniprot/Q76M53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/8022:KEF44_p09 ^@ http://purl.uniprot.org/uniprot/P68528|||http://purl.uniprot.org/uniprot/Q1L037 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Mitochondrion membrane http://togogenome.org/gene/8022:pvalb2 ^@ http://purl.uniprot.org/uniprot/E0WDA3 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8022:myog ^@ http://purl.uniprot.org/uniprot/Q91207 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/8022:rtn4 ^@ http://purl.uniprot.org/uniprot/Q4FZ68 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:rln3a ^@ http://purl.uniprot.org/uniprot/H1AFL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/8022:dio2 ^@ http://purl.uniprot.org/uniprot/Q78CG1|||http://purl.uniprot.org/uniprot/Q90VZ0 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/8022:LOC100136200 ^@ http://purl.uniprot.org/uniprot/Q6UFZ1 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8022:LOC100136778 ^@ http://purl.uniprot.org/uniprot/O57607 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the intermediate filament family.|||Expressed in all tissues examined, including epidermal keratinocytes, tongue mucosa, corneal epithelium, Meninges cells, epidermal goblet and Merkel cells, gill mucosa, basal cells of gill secondary lamellae, hepatocytes and bile canaliculi, bile duct, intestinal mucosa, blood vessel endothelial and muscle cells, interstitial cells, fibroblasts, scale-associated cells, ovary stroma and follicle, optic nerve glia, eye ciliary body, chondrocytes and kidney tubules.|||Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).|||Phosphorylated.|||There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).|||When phosphorylated, plays a role in filament reorganization. http://togogenome.org/gene/8022:mos ^@ http://purl.uniprot.org/uniprot/A9QXB2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8022:LOC100335038 ^@ http://purl.uniprot.org/uniprot/A0A060YK59|||http://purl.uniprot.org/uniprot/P51468 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arrestin family.|||Cytoplasm http://togogenome.org/gene/8022:LOC100136772 ^@ http://purl.uniprot.org/uniprot/Q04618 ^@ Caution|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Acetylation of beta-endorphin occurs in a tissue-specific manner.|||Belongs to the POMC family.|||Beta-endorphin: Endogenous orexigenic opiate.|||Endogenous opiate.|||Expressed only in sexually active fish.|||It is uncertain whether Met-1 or Met-15 is the initiator.|||Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Pituitary and hypothalamus of adult diploid animals.|||Secreted|||Specific enzymatic cleavages at paired basic residues yield the different active peptides.|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/8022:rpf1 ^@ http://purl.uniprot.org/uniprot/C1BEQ1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8022:KEF44_p10 ^@ http://purl.uniprot.org/uniprot/E2JDK3|||http://purl.uniprot.org/uniprot/P48171 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8022:lt-b2 ^@ http://purl.uniprot.org/uniprot/Q1JTL6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:ctsla ^@ http://purl.uniprot.org/uniprot/Q90WC2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8022:gpx1 ^@ http://purl.uniprot.org/uniprot/Q5UTE7|||http://purl.uniprot.org/uniprot/W8W0Y8 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/8022:fabp7b ^@ http://purl.uniprot.org/uniprot/G9HXN8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8022:cxcl8c ^@ http://purl.uniprot.org/uniprot/H1ZZ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8022:LOC100136771 ^@ http://purl.uniprot.org/uniprot/Q04617 ^@ Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Acetylation of beta-endorphin occurs in a tissue-specific manner.|||Belongs to the POMC family.|||Beta-endorphin: Endogenous orexigenic opiate.|||C-terminal peptide 1 and C-terminal peptide 2 are detected in the anterior part of the nucleus lateralis tuberis of hypothalamus, in dorsal hypothalamus, thalamus, telencephalon, optic tectum and medulla oblongata (at protein level). Expressed in pituitary and hypothalamus of adult diploid animals, and hypothalamus of triploid and ovulated female trout.|||Endogenous opiate.|||Expressed in sexually active or inactive fish.|||Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Secreted|||Specific enzymatic cleavages at paired basic residues yield the different active peptides.|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/8022:erb2 ^@ http://purl.uniprot.org/uniprot/Q0H3B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/8022:il6 ^@ http://purl.uniprot.org/uniprot/Q0GGL7 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the IL-6 superfamily.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||Expressed in spleen, gill and gastrointestinal tract, ovary and brain. Highest expression in ovary.|||Secreted|||by LPS. http://togogenome.org/gene/8022:arcn1a ^@ http://purl.uniprot.org/uniprot/B9WPL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/8022:cq032 ^@ http://purl.uniprot.org/uniprot/C1BG94 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:il-18 ^@ http://purl.uniprot.org/uniprot/Q70PK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Secreted http://togogenome.org/gene/8022:gp137 ^@ http://purl.uniprot.org/uniprot/C1BGE5 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/8022:tppc5 ^@ http://purl.uniprot.org/uniprot/C1BHU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||Part of the multisubunit TRAPP (transport protein particle) complex.|||cis-Golgi network http://togogenome.org/gene/8022:mra ^@ http://purl.uniprot.org/uniprot/Q5WP02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:nbc ^@ http://purl.uniprot.org/uniprot/Q8AYH7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8022:LOC100136690 ^@ http://purl.uniprot.org/uniprot/Q09IZ2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8022:cyp1c2 ^@ http://purl.uniprot.org/uniprot/D3XFH9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8022:LOC100135945 ^@ http://purl.uniprot.org/uniprot/Q98TW6 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8022:LOC100653466 ^@ http://purl.uniprot.org/uniprot/F2WVP7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:LOC100301685 ^@ http://purl.uniprot.org/uniprot/C1BEJ1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8022:olah ^@ http://purl.uniprot.org/uniprot/C1BFC1 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/8022:LOC100136343 ^@ http://purl.uniprot.org/uniprot/Q1HG86 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8022:LOC100136606 ^@ http://purl.uniprot.org/uniprot/Q9PT36 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8022:LOC100135894 ^@ http://purl.uniprot.org/uniprot/Q7SZV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/8022:sdy ^@ http://purl.uniprot.org/uniprot/I7GVT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:atf1 ^@ http://purl.uniprot.org/uniprot/Q3LTM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:slc30a1a ^@ http://purl.uniprot.org/uniprot/Q49LH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/8022:LOC100136105 ^@ http://purl.uniprot.org/uniprot/Q2PDG0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:rl31 ^@ http://purl.uniprot.org/uniprot/C1BF51 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/8022:slc11a2 ^@ http://purl.uniprot.org/uniprot/Q9W666 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/8022:cd40l ^@ http://purl.uniprot.org/uniprot/A9XBM0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:spcs1 ^@ http://purl.uniprot.org/uniprot/C1BIF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:rs10 ^@ http://purl.uniprot.org/uniprot/C1BFN5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/8022:LOC100136294 ^@ http://purl.uniprot.org/uniprot/P79822 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/8022:fut9 ^@ http://purl.uniprot.org/uniprot/Q70G09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/8022:mo4l1 ^@ http://purl.uniprot.org/uniprot/C1BGS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:ndufa2 ^@ http://purl.uniprot.org/uniprot/C1BI52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:psb2 ^@ http://purl.uniprot.org/uniprot/C1BH71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:bnip3 ^@ http://purl.uniprot.org/uniprot/C1BER1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/8022:psmd8 ^@ http://purl.uniprot.org/uniprot/C1BI19 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/8022:tlr5 ^@ http://purl.uniprot.org/uniprot/Q7ZT81 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/8022:cdx1 ^@ http://purl.uniprot.org/uniprot/Q6T5L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/8022:cfbl ^@ http://purl.uniprot.org/uniprot/Q9YGE7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:LOC100136736 ^@ http://purl.uniprot.org/uniprot/P18288 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.|||Belongs to the tubulin family.|||Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction (By similarity).|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).|||Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.|||Testis specific.|||The MREC motif may be critical for tubulin autoregulation.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||Tyrosination promotes microtubule interaction with CAP-Gly microtubule plus-end tracking proteins. Tyrosinated tubulins regulate the initiation of dynein-driven motility.|||Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.|||cytoskeleton http://togogenome.org/gene/8022:ndua6 ^@ http://purl.uniprot.org/uniprot/C1BF97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:LOC100136590 ^@ http://purl.uniprot.org/uniprot/Q9YGF6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:LOC100499588 ^@ http://purl.uniprot.org/uniprot/C8BMC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:ipyr ^@ http://purl.uniprot.org/uniprot/C1BI86 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/8022:rps20 ^@ http://purl.uniprot.org/uniprot/Q90YH0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/8022:LOC100136256 ^@ http://purl.uniprot.org/uniprot/Q1M162 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/8022:aakb1 ^@ http://purl.uniprot.org/uniprot/C1BHK9 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/8022:if2b ^@ http://purl.uniprot.org/uniprot/C1BGJ1 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/8022:rhbg2a ^@ http://purl.uniprot.org/uniprot/B6D1P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8022:hs020 ^@ http://purl.uniprot.org/uniprot/C1BEK8 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/8022:LOC100135903 ^@ http://purl.uniprot.org/uniprot/Q9IA29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:LOC100135907 ^@ http://purl.uniprot.org/uniprot/Q9I9M6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/8022:atp1a3 ^@ http://purl.uniprot.org/uniprot/Q6VYM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8022:LOC100136665 ^@ http://purl.uniprot.org/uniprot/Q5SE05 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/8022:LOC100135993 ^@ http://purl.uniprot.org/uniprot/Q8JJ23 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:npc2 ^@ http://purl.uniprot.org/uniprot/C1BGA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/8022:LOC100301653 ^@ http://purl.uniprot.org/uniprot/B7SFF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/8022:aass ^@ http://purl.uniprot.org/uniprot/Q5XLU9 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/8022:il17c2 ^@ http://purl.uniprot.org/uniprot/D4HTR9 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/8022:KEF44_p05 ^@ http://purl.uniprot.org/uniprot/P69302|||http://purl.uniprot.org/uniprot/Q1L033 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/8022:cast ^@ http://purl.uniprot.org/uniprot/Q49BZ3 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/8022:bdkrb1 ^@ http://purl.uniprot.org/uniprot/Q1M198 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:iip ^@ http://purl.uniprot.org/uniprot/Q8QFM4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8022:wu:fj39g12 ^@ http://purl.uniprot.org/uniprot/A0A060XWG0|||http://purl.uniprot.org/uniprot/Q8AXR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the natriuretic peptide family.|||Exhibits natriuretic and vasodepressant activity. Has a cGMP-stimulating activity.|||Expressed in brain and to a low extent in atrium.|||Secreted http://togogenome.org/gene/8022:LOC100505416 ^@ http://purl.uniprot.org/uniprot/E2IH99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8022:LOC100135991 ^@ http://purl.uniprot.org/uniprot/Q8JFR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/8022:dlc2 ^@ http://purl.uniprot.org/uniprot/Q9YGF3 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/8022:cxcr3.1 ^@ http://purl.uniprot.org/uniprot/A4F344 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/8022:LOC100136664 ^@ http://purl.uniprot.org/uniprot/Q1M194 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/8022:atp5f1c ^@ http://purl.uniprot.org/uniprot/C0KIP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/8022:gbrl2 ^@ http://purl.uniprot.org/uniprot/C1BH53 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8022:abcc2 ^@ http://purl.uniprot.org/uniprot/Q009X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:cyp2k5 ^@ http://purl.uniprot.org/uniprot/Q9IAT1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8022:tera ^@ http://purl.uniprot.org/uniprot/C1BF87 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8022:rs11 ^@ http://purl.uniprot.org/uniprot/C1BFE9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/8022:gnrh1 ^@ http://purl.uniprot.org/uniprot/Q9W7G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins. http://togogenome.org/gene/8022:LOC100135811 ^@ http://purl.uniprot.org/uniprot/O93484 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the fibrillar collagen family.|||Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.|||Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.|||The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.|||Trimers of one alpha 2(I) and two alpha 1(I) chains.|||Type I collagen is a member of group I collagen (fibrillar forming collagen).|||extracellular matrix http://togogenome.org/gene/8022:LOC100170209 ^@ http://purl.uniprot.org/uniprot/B2KL82 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/8022:il-1ra ^@ http://purl.uniprot.org/uniprot/Q575Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/8022:crj1a ^@ http://purl.uniprot.org/uniprot/C1BFR5 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/8022:polr1d ^@ http://purl.uniprot.org/uniprot/C1BEM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/8022:akirin1 ^@ http://purl.uniprot.org/uniprot/C8BMB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:ccdc58 ^@ http://purl.uniprot.org/uniprot/C1BHF5 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/8022:parapinopsina ^@ http://purl.uniprot.org/uniprot/Q75R38 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8022:LOC101867532 ^@ http://purl.uniprot.org/uniprot/G9B9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:ar-beta ^@ http://purl.uniprot.org/uniprot/O93245 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:med21 ^@ http://purl.uniprot.org/uniprot/C1BFI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8022:mif ^@ http://purl.uniprot.org/uniprot/Q0ZBR8 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/8022:opi-2 ^@ http://purl.uniprot.org/uniprot/Q8AX91 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:dimt1l ^@ http://purl.uniprot.org/uniprot/C1BHG9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/8022:tshba ^@ http://purl.uniprot.org/uniprot/A0A060VXM2|||http://purl.uniprot.org/uniprot/P37240 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Indispensable for the control of thyroid structure and metabolism. May play some role in the biological processes of the immature fishes.|||It is uncertain whether Met-1 or Met-7 is the initiator.|||Pituitary gland. Higher levels seen in immature fishes than the mature fishes.|||Secreted http://togogenome.org/gene/8022:pax-5 ^@ http://purl.uniprot.org/uniprot/A8DB63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:gale ^@ http://purl.uniprot.org/uniprot/C1BI55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/8022:cpi1 ^@ http://purl.uniprot.org/uniprot/Q64HX6 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/8022:ifm3 ^@ http://purl.uniprot.org/uniprot/C1BI59 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8022:sar1a ^@ http://purl.uniprot.org/uniprot/C1BG51 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/8022:pax7b ^@ http://purl.uniprot.org/uniprot/H9NNC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8022:LOC100136287 ^@ http://purl.uniprot.org/uniprot/Q1X7P4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8022:tlr3 ^@ http://purl.uniprot.org/uniprot/Q1PA38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8022:LOC100136703 ^@ http://purl.uniprot.org/uniprot/A3RID7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/8022:LOC100135807 ^@ http://purl.uniprot.org/uniprot/Q8QHL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/8022:LOC100135859 ^@ http://purl.uniprot.org/uniprot/Q9YGF2 ^@ Function|||PTM|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).|||Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. http://togogenome.org/gene/8022:stx7 ^@ http://purl.uniprot.org/uniprot/C1BHQ8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8022:LOC100136320 ^@ http://purl.uniprot.org/uniprot/Q2I7F3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:rdh3 ^@ http://purl.uniprot.org/uniprot/C1BGU8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8022:nos2 ^@ http://purl.uniprot.org/uniprot/Q8AXU2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/8022:ikzf1 ^@ http://purl.uniprot.org/uniprot/O13089 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the Ikaros C2H2-type zinc-finger protein family.|||Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).|||Expression begins at day 3-4 in the yolk sac and at day 5-6 in the embryo proper.|||Expression mainly limited to thymus, spleen and pronephros. Very low expression in liver. No expression in testis, brain, eye and muscle.|||Nucleus http://togogenome.org/gene/8022:lipe1 ^@ http://purl.uniprot.org/uniprot/E2JFF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||Cell membrane|||Lipid droplet|||caveola|||cytosol http://togogenome.org/gene/8022:si:ch1073-280e3.1 ^@ http://purl.uniprot.org/uniprot/Q9DEC8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:sc61g ^@ http://purl.uniprot.org/uniprot/C1BGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:irf2 ^@ http://purl.uniprot.org/uniprot/Q8JH40 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:hhex ^@ http://purl.uniprot.org/uniprot/C1BGY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:sod1 ^@ http://purl.uniprot.org/uniprot/Q8QHI0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/8022:pop5 ^@ http://purl.uniprot.org/uniprot/C1BFT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/8022:sox9 ^@ http://purl.uniprot.org/uniprot/Q9DE39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:mstn2a ^@ http://purl.uniprot.org/uniprot/Q0R338 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/8022:zn706 ^@ http://purl.uniprot.org/uniprot/C1BFE8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8022:adra1b ^@ http://purl.uniprot.org/uniprot/Q3S2N8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/8022:il21r ^@ http://purl.uniprot.org/uniprot/A1IMI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:psb9 ^@ http://purl.uniprot.org/uniprot/Q5FBU2|||http://purl.uniprot.org/uniprot/Q9PT27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8022:LOC100136237 ^@ http://purl.uniprot.org/uniprot/Q1M197 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8022:ywhag2 ^@ http://purl.uniprot.org/uniprot/Q6UFZ2 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).|||Belongs to the 14-3-3 family.|||Cytoplasm|||Expressed from the 34 somite stage.|||Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skeletal muscle, spleen and testis.|||Homodimer, and heterodimer with other family members.|||Repressed under stress conditions such as netting. http://togogenome.org/gene/8022:LOC100499615 ^@ http://purl.uniprot.org/uniprot/D7REY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/8022:gp130 ^@ http://purl.uniprot.org/uniprot/G7Z194 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/8022:sec22bb ^@ http://purl.uniprot.org/uniprot/C1BID8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/8022:si:dkey-88e18.2 ^@ http://purl.uniprot.org/uniprot/Q5DVP7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/8022:vamp5 ^@ http://purl.uniprot.org/uniprot/C1BFP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/8022:ct030 ^@ http://purl.uniprot.org/uniprot/C1BH90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||Vesicle|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/8022:LOC100136173 ^@ http://purl.uniprot.org/uniprot/Q6XQJ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:cox-2 ^@ http://purl.uniprot.org/uniprot/Q9W715 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Endoplasmic reticulum membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/8022:arf1 ^@ http://purl.uniprot.org/uniprot/C1BHU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8022:hsp90ab1 ^@ http://purl.uniprot.org/uniprot/Q5DW66 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8022:tdt ^@ http://purl.uniprot.org/uniprot/Q92089 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. http://togogenome.org/gene/8022:rhcg1-b ^@ http://purl.uniprot.org/uniprot/A8QJ81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8022:ube2c ^@ http://purl.uniprot.org/uniprot/C1BER0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8022:pfdn1 ^@ http://purl.uniprot.org/uniprot/C1BGH7 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/8022:LOC100499586 ^@ http://purl.uniprot.org/uniprot/C8BMC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8022:LOC100136222 ^@ http://purl.uniprot.org/uniprot/Q56V27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:arpc5l ^@ http://purl.uniprot.org/uniprot/C1BHV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.|||cytoskeleton http://togogenome.org/gene/8022:LOC100136292 ^@ http://purl.uniprot.org/uniprot/Q91216 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:plm ^@ http://purl.uniprot.org/uniprot/C1BI48 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/8022:LOC100301695 ^@ http://purl.uniprot.org/uniprot/C1BEN4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/8022:wnt4a2 ^@ http://purl.uniprot.org/uniprot/G9DAQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8022:cbpa1 ^@ http://purl.uniprot.org/uniprot/C1BHH4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/8022:cebpd ^@ http://purl.uniprot.org/uniprot/A5X2W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/8022:becn1 ^@ http://purl.uniprot.org/uniprot/Q4A1L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/8022:tlr9 ^@ http://purl.uniprot.org/uniprot/B2MW43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8022:pfdn6 ^@ http://purl.uniprot.org/uniprot/C1BEP1 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/8022:c8g ^@ http://purl.uniprot.org/uniprot/Q6H963 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8022:LOC100136181 ^@ http://purl.uniprot.org/uniprot/Q7SYF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/8022:gs04 ^@ http://purl.uniprot.org/uniprot/Q8JI31 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8022:LOC100135817 ^@ http://purl.uniprot.org/uniprot/Q805B8 ^@ Function|||Similarity ^@ Belongs to the calcitonin family.|||Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. http://togogenome.org/gene/8022:vnp ^@ http://purl.uniprot.org/uniprot/Q7T2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/8022:ssrb ^@ http://purl.uniprot.org/uniprot/C1BG14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/8022:hmgb1a ^@ http://purl.uniprot.org/uniprot/P07746 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Binds preferentially single-stranded DNA and unwinds double-stranded DNA.|||Chromosome|||Nucleus http://togogenome.org/gene/8022:camk1b ^@ http://purl.uniprot.org/uniprot/Q64HW3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8022:casp3b ^@ http://purl.uniprot.org/uniprot/E7BBR2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8022:LOC100136607 ^@ http://purl.uniprot.org/uniprot/Q9W6M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/8022:LOC100136247 ^@ http://purl.uniprot.org/uniprot/Q64HW6 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/8022:pvalb1 ^@ http://purl.uniprot.org/uniprot/E0WDA2 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8022:LOC100305288 ^@ http://purl.uniprot.org/uniprot/C1BI39 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/8022:LOC100136107 ^@ http://purl.uniprot.org/uniprot/Q2PDF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100135825 ^@ http://purl.uniprot.org/uniprot/Q762J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8022:rgn ^@ http://purl.uniprot.org/uniprot/F2RM22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/8022:hspa8 ^@ http://purl.uniprot.org/uniprot/P08108|||http://purl.uniprot.org/uniprot/Q5DW63 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8022:LOC100379111 ^@ http://purl.uniprot.org/uniprot/A5X2V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/8022:LOC100136655 ^@ http://purl.uniprot.org/uniprot/Q6XQJ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:LOC100136271 ^@ http://purl.uniprot.org/uniprot/Q5UEM3 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/8022:traf2 ^@ http://purl.uniprot.org/uniprot/Q7T2X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/8022:slc9a1b ^@ http://purl.uniprot.org/uniprot/Q01345 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Activated by cAMP, protein kinase A and protein kinase C.|||Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+).|||Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. http://togogenome.org/gene/8022:csn6 ^@ http://purl.uniprot.org/uniprot/C1BFX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:glut1a ^@ http://purl.uniprot.org/uniprot/Q9I8M1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8022:c5h9orf78 ^@ http://purl.uniprot.org/uniprot/C1BFP3 ^@ Similarity ^@ Belongs to the TLS1 family. http://togogenome.org/gene/8022:dmrt1 ^@ http://purl.uniprot.org/uniprot/Q9DG19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/8022:cd74b ^@ http://purl.uniprot.org/uniprot/Q8JFN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:cn112 ^@ http://purl.uniprot.org/uniprot/C1BHU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane http://togogenome.org/gene/8022:trmt112 ^@ http://purl.uniprot.org/uniprot/C1BHA2 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/8022:cyp1c1 ^@ http://purl.uniprot.org/uniprot/D3XFH7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8022:hspa8b ^@ http://purl.uniprot.org/uniprot/C1BEL8 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8022:spp2 ^@ http://purl.uniprot.org/uniprot/A0A060YFX4|||http://purl.uniprot.org/uniprot/Q70I47 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Multiply phosphorylated at serine residues.|||Secreted http://togogenome.org/gene/8022:si:dkey-42l23.2 ^@ http://purl.uniprot.org/uniprot/C1BI79 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:rtn3 ^@ http://purl.uniprot.org/uniprot/Q6IEJ2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:zgc:92907 ^@ http://purl.uniprot.org/uniprot/C1BGJ4 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/8022:notch1 ^@ http://purl.uniprot.org/uniprot/B5U9W5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/8022:chmp2a ^@ http://purl.uniprot.org/uniprot/C1BGQ5 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8022:hsp70a ^@ http://purl.uniprot.org/uniprot/Q5KT35 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8022:ss18l2 ^@ http://purl.uniprot.org/uniprot/C1BH49 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/8022:cahz ^@ http://purl.uniprot.org/uniprot/Q7T2K6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8022:fabp3 ^@ http://purl.uniprot.org/uniprot/O13008 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.|||Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. http://togogenome.org/gene/8022:LOC100329197 ^@ http://purl.uniprot.org/uniprot/Q335X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8022:grp94 ^@ http://purl.uniprot.org/uniprot/D9UB75 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8022:KEF44_p04 ^@ http://purl.uniprot.org/uniprot/P11631 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Mitochondrion membrane http://togogenome.org/gene/8022:nxt2 ^@ http://purl.uniprot.org/uniprot/C1BF84 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/8022:foxp3-1 ^@ http://purl.uniprot.org/uniprot/E4W7U4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:gata3 ^@ http://purl.uniprot.org/uniprot/E1UGZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:rl26 ^@ http://purl.uniprot.org/uniprot/C1BFB0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/8022:LOC100135941 ^@ http://purl.uniprot.org/uniprot/Q7SXA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/8022:idi1 ^@ http://purl.uniprot.org/uniprot/C1BFN0 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/8022:ecac ^@ http://purl.uniprot.org/uniprot/Q7ZZQ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100136296 ^@ http://purl.uniprot.org/uniprot/Q98973 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:hcn1 ^@ http://purl.uniprot.org/uniprot/Q71N53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:rs15 ^@ http://purl.uniprot.org/uniprot/C1BHW8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/8022:nme7 ^@ http://purl.uniprot.org/uniprot/C1BEX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/8022:rhcg ^@ http://purl.uniprot.org/uniprot/Q4VUZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity).|||Homotrimer. http://togogenome.org/gene/8022:cj104 ^@ http://purl.uniprot.org/uniprot/C1BF61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/8022:xip ^@ http://purl.uniprot.org/uniprot/C1BF47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/8022:il10b ^@ http://purl.uniprot.org/uniprot/F8K872 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/8022:LOC100136198 ^@ http://purl.uniprot.org/uniprot/Q6UFZ3 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).|||Belongs to the 14-3-3 family.|||Cytoplasm|||Expressed from late gastrula onwards.|||Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skeletal muscle, spleen and testis.|||Homodimer, and heterodimer with other family members.|||Repressed under stress conditions such as netting. http://togogenome.org/gene/8022:pigh ^@ http://purl.uniprot.org/uniprot/C1BF95 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/8022:KEF44_p06 ^@ http://purl.uniprot.org/uniprot/P11629|||http://purl.uniprot.org/uniprot/Q1L034 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/8022:apoa-i-1 ^@ http://purl.uniprot.org/uniprot/O57523 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein A1/A4/E family.|||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).|||Secreted http://togogenome.org/gene/8022:spcs3 ^@ http://purl.uniprot.org/uniprot/C1BER9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8022:LOC100135856 ^@ http://purl.uniprot.org/uniprot/A0PAB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8022:mx2 ^@ http://purl.uniprot.org/uniprot/Q91196 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.|||Cytoplasm|||Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).|||Nucleus http://togogenome.org/gene/8022:LOC100136955 ^@ http://purl.uniprot.org/uniprot/Q91452 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.|||Membrane http://togogenome.org/gene/8022:mmp9 ^@ http://purl.uniprot.org/uniprot/Q8QFQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/8022:cxcr3.2 ^@ http://purl.uniprot.org/uniprot/A4F341|||http://purl.uniprot.org/uniprot/A4F342|||http://purl.uniprot.org/uniprot/A4F343 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:LOC100136712 ^@ http://purl.uniprot.org/uniprot/A6ZIC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/8022:msra ^@ http://purl.uniprot.org/uniprot/C1BFM0 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/8022:LOC100301670 ^@ http://purl.uniprot.org/uniprot/C0KTH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/8022:hbegf ^@ http://purl.uniprot.org/uniprot/C1BHT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:pdrg1 ^@ http://purl.uniprot.org/uniprot/C1BGA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/8022:tmeda ^@ http://purl.uniprot.org/uniprot/C1BG31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:kcnh2 ^@ http://purl.uniprot.org/uniprot/A7LA95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.|||Membrane http://togogenome.org/gene/8022:nr3c1 ^@ http://purl.uniprot.org/uniprot/Q6RKQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/8022:myod2 ^@ http://purl.uniprot.org/uniprot/Q91206 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/8022:wnt4b ^@ http://purl.uniprot.org/uniprot/G9DAQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8022:LOC100135967 ^@ http://purl.uniprot.org/uniprot/Q90ZQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/8022:stat5 ^@ http://purl.uniprot.org/uniprot/Q9DG74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:foxl2l ^@ http://purl.uniprot.org/uniprot/Q6EAP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:il-8 ^@ http://purl.uniprot.org/uniprot/Q98TQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/8022:LOC100136258 ^@ http://purl.uniprot.org/uniprot/Q1M159 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasm|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium http://togogenome.org/gene/8022:rbhce2 ^@ http://purl.uniprot.org/uniprot/D2YYG3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:LOC100136024 ^@ http://purl.uniprot.org/uniprot/A0A060WTK5|||http://purl.uniprot.org/uniprot/Q9YGD3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ All three isoforms are expressed in gill, kidney, liver and spleen. Isoform 1 is also expressed in blood. None of the isoforms are expressed in brain.|||Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/8022:krt5 ^@ http://purl.uniprot.org/uniprot/Q90W75 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8022:nola3 ^@ http://purl.uniprot.org/uniprot/C1BGB0 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/8022:LOC100135798 ^@ http://purl.uniprot.org/uniprot/Q9PT09 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/8022:apoc2 ^@ http://purl.uniprot.org/uniprot/Q9DG75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Secreted http://togogenome.org/gene/8022:nedd8 ^@ http://purl.uniprot.org/uniprot/C1BFL8 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/8022:hsp47 ^@ http://purl.uniprot.org/uniprot/Q5DW60 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/8022:LOC100136046 ^@ http://purl.uniprot.org/uniprot/Q711N8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/8022:LOC100136293 ^@ http://purl.uniprot.org/uniprot/P79821 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/8022:polr2i ^@ http://purl.uniprot.org/uniprot/C1BGM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/8022:st3gal-i ^@ http://purl.uniprot.org/uniprot/Q70D59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8022:cck-t ^@ http://purl.uniprot.org/uniprot/Q9YGE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/8022:LOC100136266 ^@ http://purl.uniprot.org/uniprot/Q64FL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:LOC100136663 ^@ http://purl.uniprot.org/uniprot/Q64HX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/8022:ckba ^@ http://purl.uniprot.org/uniprot/P24722 ^@ Function|||Similarity|||Tissue Specificity ^@ Belongs to the ATP:guanido phosphotransferase family.|||Exists in many tissues, but preferentially in testis.|||Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. http://togogenome.org/gene/8022:sumo2 ^@ http://purl.uniprot.org/uniprot/C1BGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/8022:ifn1 ^@ http://purl.uniprot.org/uniprot/Q5U778 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/8022:LOC100136193 ^@ http://purl.uniprot.org/uniprot/Q6UFZ8 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).|||Belongs to the 14-3-3 family.|||Cytoplasm|||Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skeletal muscle, spleen and testis.|||Expressed throughout development.|||Homodimer, and heterodimer with other family members.|||Repressed under stress conditions such as netting. http://togogenome.org/gene/8022:gtf2a2 ^@ http://purl.uniprot.org/uniprot/C1BFG8|||http://purl.uniprot.org/uniprot/Q90YG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).|||TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit. Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP (By similarity). http://togogenome.org/gene/8022:LOC100170204 ^@ http://purl.uniprot.org/uniprot/Q8QGB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8022:fam32a ^@ http://purl.uniprot.org/uniprot/C1BGR5 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/8022:litaf ^@ http://purl.uniprot.org/uniprot/C1BHA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/8022:gbg5 ^@ http://purl.uniprot.org/uniprot/C1BGH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8022:mul1b ^@ http://purl.uniprot.org/uniprot/I1W5K1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:wt1b ^@ http://purl.uniprot.org/uniprot/Q90XX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/8022:LOC100135902 ^@ http://purl.uniprot.org/uniprot/Q9I8S9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.|||Nucleus http://togogenome.org/gene/8022:LOC100135826 ^@ http://purl.uniprot.org/uniprot/Q68YC2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8022:LOC100136214 ^@ http://purl.uniprot.org/uniprot/Q6EAN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:LOC100135834 ^@ http://purl.uniprot.org/uniprot/Q5TM02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:tnr5 ^@ http://purl.uniprot.org/uniprot/C1BI10 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:tradd ^@ http://purl.uniprot.org/uniprot/A0A060W3P9|||http://purl.uniprot.org/uniprot/Q1M161 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.|||Cytoplasm|||Heterodimer with tnfrsf1a.|||Nucleus|||Requires the intact death domain to associate with tnfrsf1a.|||cytoskeleton http://togogenome.org/gene/8022:ei2ba ^@ http://purl.uniprot.org/uniprot/C1BGT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/8022:tfa ^@ http://purl.uniprot.org/uniprot/Q9PT13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted|||Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. http://togogenome.org/gene/8022:hsp70b ^@ http://purl.uniprot.org/uniprot/Q5KT34 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8022:il-1r1 ^@ http://purl.uniprot.org/uniprot/Q8AXU1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/8022:cyp11b ^@ http://purl.uniprot.org/uniprot/Q9PT16 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8022:selenof ^@ http://purl.uniprot.org/uniprot/Q6X4M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the selenoprotein M/F family.|||Endoplasmic reticulum lumen|||Expressed in the brain, liver and retina. Localized to the retinal ganglion cell layer, the inner nuclear layer and the outer nuclear layer at both parr and smolt stages.|||May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity). May be involved in retinal development. http://togogenome.org/gene/8022:piwil2 ^@ http://purl.uniprot.org/uniprot/A6P7L8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Piwi subfamily.|||Component of the PET complex.|||Cytoplasm|||Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' piwil4. Piwil2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded. Required for piwil4/miwi2 nuclear localization and association with secondary piRNAs antisense.|||Methylated on arginine residues; required for the interaction with Tudor domain-containing protein and subsequent localization to the meiotic nuage, also named P granule.|||Nucleus http://togogenome.org/gene/8022:imp3 ^@ http://purl.uniprot.org/uniprot/C1BGU9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/8022:LOC100136291 ^@ http://purl.uniprot.org/uniprot/P02141 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from gills to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/8022:drd2a ^@ http://purl.uniprot.org/uniprot/Q90WQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100136249 ^@ http://purl.uniprot.org/uniprot/Q1M177 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8022:LOC100136950 ^@ http://purl.uniprot.org/uniprot/Q76KE8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:sox11b ^@ http://purl.uniprot.org/uniprot/O57399 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:bola3 ^@ http://purl.uniprot.org/uniprot/C1BFU2 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/8022:rl36a ^@ http://purl.uniprot.org/uniprot/C1BGZ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/8022:anp ^@ http://purl.uniprot.org/uniprot/Q7T2I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/8022:igf2b ^@ http://purl.uniprot.org/uniprot/C6GBY8|||http://purl.uniprot.org/uniprot/Q02816 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. http://togogenome.org/gene/8022:LOC100136309 ^@ http://purl.uniprot.org/uniprot/Q0H7E4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer. Can form a heterodimer with ER-beta.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/8022:gbg2 ^@ http://purl.uniprot.org/uniprot/C1BH40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8022:saa ^@ http://purl.uniprot.org/uniprot/A6PZ09 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/8022:dynlt1 ^@ http://purl.uniprot.org/uniprot/C1BF42 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/8022:tnfsf13b ^@ http://purl.uniprot.org/uniprot/Q2I7F7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:car8 ^@ http://purl.uniprot.org/uniprot/Q5I2J1 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/8022:serpinf2b ^@ http://purl.uniprot.org/uniprot/F8LFR3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8022:LOC100136251 ^@ http://purl.uniprot.org/uniprot/Q64HW4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8022:cx43 ^@ http://purl.uniprot.org/uniprot/Q3HNW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8022:fbxo32 ^@ http://purl.uniprot.org/uniprot/D9IV46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:rbp4 ^@ http://purl.uniprot.org/uniprot/Q90Y51 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8022:rs21 ^@ http://purl.uniprot.org/uniprot/C1BGB5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/8022:nifk ^@ http://purl.uniprot.org/uniprot/C1BG54 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8022:sec20 ^@ http://purl.uniprot.org/uniprot/C1BI84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:LOC100136280 ^@ http://purl.uniprot.org/uniprot/Q5FXK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Nucleus|||Secreted http://togogenome.org/gene/8022:cklf7 ^@ http://purl.uniprot.org/uniprot/C1BIE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:lpl ^@ http://purl.uniprot.org/uniprot/Q9W6Y2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/8022:chmp5b ^@ http://purl.uniprot.org/uniprot/C1BHT1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8022:ftz-f1 ^@ http://purl.uniprot.org/uniprot/Q5EIB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/8022:antiprot1 ^@ http://purl.uniprot.org/uniprot/Q7ZZW1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8022:ifih1 ^@ http://purl.uniprot.org/uniprot/D7F7W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/8022:LOC100136122 ^@ http://purl.uniprot.org/uniprot/Q4LBC8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the tollip family.|||Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.|||Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).|||Cytoplasm|||Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).|||Ubiquitous. http://togogenome.org/gene/8022:LOC100135906 ^@ http://purl.uniprot.org/uniprot/Q9I9M8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:prf1 ^@ http://purl.uniprot.org/uniprot/Q0VJ92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/8022:cetn4 ^@ http://purl.uniprot.org/uniprot/C1BFN9 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/8022:LOC100136246 ^@ http://purl.uniprot.org/uniprot/Q1M179 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8022:gcg1 ^@ http://purl.uniprot.org/uniprot/Q91971 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.|||Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.|||Secreted http://togogenome.org/gene/8022:LOC100136696 ^@ http://purl.uniprot.org/uniprot/A0SZ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/8022:ga45b ^@ http://purl.uniprot.org/uniprot/C1BER7 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/8022:igfbp1a ^@ http://purl.uniprot.org/uniprot/G3GJ68 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:pgpi ^@ http://purl.uniprot.org/uniprot/C1BG35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/8022:KEF44_p11 ^@ http://purl.uniprot.org/uniprot/E2JDJ7|||http://purl.uniprot.org/uniprot/P48170 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 2 heme A groups non-covalently per subunit.|||Binds a copper B center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8022:mc1r ^@ http://purl.uniprot.org/uniprot/D6CIN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/8022:LOC100135946 ^@ http://purl.uniprot.org/uniprot/P43648 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.|||Produced and secreted by the corpuscles of Stannius.|||Secreted http://togogenome.org/gene/8022:taf12 ^@ http://purl.uniprot.org/uniprot/C1BFS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/8022:sparc ^@ http://purl.uniprot.org/uniprot/Q9YGD9 ^@ Similarity ^@ Belongs to the SPARC family. http://togogenome.org/gene/8022:eif5a ^@ http://purl.uniprot.org/uniprot/C1BG36 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/8022:pfn1 ^@ http://purl.uniprot.org/uniprot/C1BHQ1 ^@ Function|||Similarity ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. http://togogenome.org/gene/8022:ssr3 ^@ http://purl.uniprot.org/uniprot/C1BF31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/8022:LOC100135786 ^@ http://purl.uniprot.org/uniprot/O57397 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/8022:ccl4 ^@ http://purl.uniprot.org/uniprot/Q64IC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/8022:pigp ^@ http://purl.uniprot.org/uniprot/C1BGD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/8022:asip1 ^@ http://purl.uniprot.org/uniprot/D6CIN2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8022:vegf ^@ http://purl.uniprot.org/uniprot/Q6H8S7 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/8022:rl28 ^@ http://purl.uniprot.org/uniprot/C1BFH9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/8022:s8 ^@ http://purl.uniprot.org/uniprot/Q90W73 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8022:ngb ^@ http://purl.uniprot.org/uniprot/P59743 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the globin family.|||Cytoplasm|||Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Capable of penetrating cell membranes (By similarity).|||Monomer.|||Perikaryon http://togogenome.org/gene/8022:LOC100136702 ^@ http://purl.uniprot.org/uniprot/A3RID6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/8022:LOC100135961 ^@ http://purl.uniprot.org/uniprot/A0A060XW28|||http://purl.uniprot.org/uniprot/Q98SN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).|||Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.|||Membrane http://togogenome.org/gene/8022:leap2 ^@ http://purl.uniprot.org/uniprot/Q64KQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/8022:LOC100136195 ^@ http://purl.uniprot.org/uniprot/Q6UFZ6 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8022:tppc3 ^@ http://purl.uniprot.org/uniprot/C1BH07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/8022:nppb ^@ http://purl.uniprot.org/uniprot/Q4AEE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/8022:LOC100135879 ^@ http://purl.uniprot.org/uniprot/Q9YGD6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8022:casp6 ^@ http://purl.uniprot.org/uniprot/C1BI95 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8022:chi ^@ http://purl.uniprot.org/uniprot/Q5NKG0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/8022:snrpd3l ^@ http://purl.uniprot.org/uniprot/C1BFR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/8022:c4b ^@ http://purl.uniprot.org/uniprot/Q70TF5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8022:pb1 ^@ http://purl.uniprot.org/uniprot/C1BFT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:eif3h ^@ http://purl.uniprot.org/uniprot/C1BGV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8022:balm ^@ http://purl.uniprot.org/uniprot/Q2I7F5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:ube2b ^@ http://purl.uniprot.org/uniprot/C1BEI3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8022:apoe ^@ http://purl.uniprot.org/uniprot/Q9PT02 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/8022:otulina ^@ http://purl.uniprot.org/uniprot/C1BF67 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8022:il4r2 ^@ http://purl.uniprot.org/uniprot/E6ZCC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:arnt ^@ http://purl.uniprot.org/uniprot/P79832 ^@ Developmental Stage|||Domain|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Efficient DNA-binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR).|||Expressed at much lower levels than isoform 1.|||Has reduced affinity for the XRE and functions negatively in AHR-mediated signaling by disrupting the binding of dimers formed by isoform 1 and AHR to the XRE.|||In day 23 embryos, expressed at highest levels in brain, spinal cord and epithelial cells of developing gill. Expressed at higher levels throughout all tissues in day 27 and 35 sac fry, predominantly in brain and spinal cord. In the adult, isoform 1 is widely expressed (at protein level) and is detected in liver, gill, gonad, brain, kidney, heart, spleen and muscle. Isoform 2 is expressed (at protein level) only in gills with highest expression in the epithelial cells sourrounding the gill lamellae.|||Isoform 1 is expressed both in juvenile and adult with highest levels in day 42 sac fry. Isoform 2 is only expressed in adult (at protein level).|||Nucleus|||Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:11230806, PubMed:8940073). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).|||The C-terminal region of isoform 1 contains a transactivation domain. The Pro/Ser/Thr-rich region in the C-terminus of isoform 2 inhibits DNA-binding of ARNT-AHR dimers. http://togogenome.org/gene/8022:LOC101268960 ^@ http://purl.uniprot.org/uniprot/L7UKG5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:pad ^@ http://purl.uniprot.org/uniprot/B9WPX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/8022:chrna9 ^@ http://purl.uniprot.org/uniprot/Q68RJ7 ^@ Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.|||Cell membrane|||Expressed in the brain, liver, olfactory mucosa, pituitary gland and hair cells of the saccule.|||Postsynaptic cell membrane http://togogenome.org/gene/8022:masp1 ^@ http://purl.uniprot.org/uniprot/B5KWB0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:cox-1 ^@ http://purl.uniprot.org/uniprot/Q9DEQ0 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:gdh03 ^@ http://purl.uniprot.org/uniprot/Q8JHX9 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/8022:cxcl12b ^@ http://purl.uniprot.org/uniprot/H1ZZ94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8022:wdr82 ^@ http://purl.uniprot.org/uniprot/C1BIG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/8022:rfa3 ^@ http://purl.uniprot.org/uniprot/C1BGW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/8022:LOC100653464 ^@ http://purl.uniprot.org/uniprot/F1DRC4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:rtgdnf ^@ http://purl.uniprot.org/uniprot/M1VK54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/8022:lyrm1 ^@ http://purl.uniprot.org/uniprot/C1BIA4 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/8022:LOC100301658 ^@ http://purl.uniprot.org/uniprot/B8YI11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:gfra1a ^@ http://purl.uniprot.org/uniprot/M1UZC9 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/8022:cf191 ^@ http://purl.uniprot.org/uniprot/C1BG33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:eomesb ^@ http://purl.uniprot.org/uniprot/J9PYB5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:irf-10 ^@ http://purl.uniprot.org/uniprot/D8FRP0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:LOC100305272 ^@ http://purl.uniprot.org/uniprot/C1BHX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/8022:cyp1c3 ^@ http://purl.uniprot.org/uniprot/D3XFH8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8022:tf ^@ http://purl.uniprot.org/uniprot/Q90W13 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/8022:ndus5 ^@ http://purl.uniprot.org/uniprot/C1BH75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8022:s10i ^@ http://purl.uniprot.org/uniprot/C1BHS7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/8022:ucn ^@ http://purl.uniprot.org/uniprot/O93448 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted|||Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor. The non-hormonal portion of this precursor may be a urotensin binding protein, urophysin. http://togogenome.org/gene/8022:LOC100136288 ^@ http://purl.uniprot.org/uniprot/Q1X7P3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8022:frih ^@ http://purl.uniprot.org/uniprot/C1BEL9 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/8022:leg1 ^@ http://purl.uniprot.org/uniprot/Q5QT17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||May be involved in early liver development.|||Secreted http://togogenome.org/gene/8022:rtor1 ^@ http://purl.uniprot.org/uniprot/Q1XG38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:opi-1 ^@ http://purl.uniprot.org/uniprot/Q8AWW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:dck ^@ http://purl.uniprot.org/uniprot/C1BHG5 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/8022:prdx1 ^@ http://purl.uniprot.org/uniprot/Q9I886 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/8022:LOC100135862 ^@ http://purl.uniprot.org/uniprot/O42241 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins. http://togogenome.org/gene/8022:tlr22 ^@ http://purl.uniprot.org/uniprot/Q6KCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8022:rcl1 ^@ http://purl.uniprot.org/uniprot/C1BFN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.|||nucleolus http://togogenome.org/gene/8022:cfh ^@ http://purl.uniprot.org/uniprot/Q2L4Q6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:you2 ^@ http://purl.uniprot.org/uniprot/C1BFV7 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/8022:psb8 ^@ http://purl.uniprot.org/uniprot/C1BID7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8022:bpnt1 ^@ http://purl.uniprot.org/uniprot/C1BFL2 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/8022:rblce ^@ http://purl.uniprot.org/uniprot/D2YYG4 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:arl2 ^@ http://purl.uniprot.org/uniprot/C1BIF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/8022:nfip1 ^@ http://purl.uniprot.org/uniprot/C1BEY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:LOC100136769 ^@ http://purl.uniprot.org/uniprot/P32847 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. http://togogenome.org/gene/8022:LOC100136140 ^@ http://purl.uniprot.org/uniprot/Q0E757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/8022:ghs-r ^@ http://purl.uniprot.org/uniprot/A8CGH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). http://togogenome.org/gene/8022:tgfr2 ^@ http://purl.uniprot.org/uniprot/I2FKQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/8022:vatf ^@ http://purl.uniprot.org/uniprot/C1BEU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8022:ccr9a ^@ http://purl.uniprot.org/uniprot/O42444 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8022:stt3a ^@ http://purl.uniprot.org/uniprot/C1BGI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/8022:iip2 ^@ http://purl.uniprot.org/uniprot/Q8QFL3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8022:c3ar1 ^@ http://purl.uniprot.org/uniprot/Q2WED0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks an insertion found in the C3ar family. It remains uncertain whether it belongs to the C3ar or the C5ar family.|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity). http://togogenome.org/gene/8022:rpl37a ^@ http://purl.uniprot.org/uniprot/C1BH43 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/8022:LOC100135793 ^@ http://purl.uniprot.org/uniprot/Q9W635 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/8022:bl1s3 ^@ http://purl.uniprot.org/uniprot/C1BFC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S3 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).|||Cytoplasm http://togogenome.org/gene/8022:dgcr6 ^@ http://purl.uniprot.org/uniprot/C1BEX0 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/8022:arpin ^@ http://purl.uniprot.org/uniprot/C1BHE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arpin family.|||lamellipodium http://togogenome.org/gene/8022:prl ^@ http://purl.uniprot.org/uniprot/A0A060WYA2|||http://purl.uniprot.org/uniprot/P21993 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/8022:LOC100135972 ^@ http://purl.uniprot.org/uniprot/Q90ZP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:crf ^@ http://purl.uniprot.org/uniprot/Q6YDN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/8022:suclg1 ^@ http://purl.uniprot.org/uniprot/C0KIP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/8022:il2rb2 ^@ http://purl.uniprot.org/uniprot/G4RJE1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100136185 ^@ http://purl.uniprot.org/uniprot/Q6VYM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8022:rrmj2 ^@ http://purl.uniprot.org/uniprot/C1BI54 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/8022:coq7 ^@ http://purl.uniprot.org/uniprot/C1BG71 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:sptssa ^@ http://purl.uniprot.org/uniprot/C1BHM8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:LOC100136790 ^@ http://purl.uniprot.org/uniprot/B0L0M1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/8022:cpt1ab ^@ http://purl.uniprot.org/uniprot/D9Z8Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8022:alox5ap ^@ http://purl.uniprot.org/uniprot/C1BIG0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/8022:oclna ^@ http://purl.uniprot.org/uniprot/D7NZJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8022:fd6d ^@ http://purl.uniprot.org/uniprot/Q98SW7 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/8022:ctsbb ^@ http://purl.uniprot.org/uniprot/Q90WC3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8022:c5ar ^@ http://purl.uniprot.org/uniprot/A0A060YND6|||http://purl.uniprot.org/uniprot/Q6UNA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High expression in head, kidney and posterior kidney, lower levels in peripheral blood leukocytes and spleen, low expression in brain and gills, heart, intestine and very low expression in liver and muscle.|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/8022:LOC101268922 ^@ http://purl.uniprot.org/uniprot/G9B9Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:LOC100136303 ^@ http://purl.uniprot.org/uniprot/Q2LK91 ^@ Function|||Similarity|||Subunit ^@ Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.|||Belongs to the fucolectin family.|||Homotrimer. http://togogenome.org/gene/8022:LOC100136711 ^@ http://purl.uniprot.org/uniprot/A9LHI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8022:c7a ^@ http://purl.uniprot.org/uniprot/Q6H965 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:bc10 ^@ http://purl.uniprot.org/uniprot/C1BEP0 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/8022:ciao2b ^@ http://purl.uniprot.org/uniprot/C1BHI3 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/8022:bambia ^@ http://purl.uniprot.org/uniprot/B7SFF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/8022:rag1 ^@ http://purl.uniprot.org/uniprot/Q91187 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).|||Homodimer. Component of the RAG complex composed of core components rag1 and rag2 (By similarity).|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.|||The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity. http://togogenome.org/gene/8022:atpbb ^@ http://purl.uniprot.org/uniprot/C1BHQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/8022:cd3z ^@ http://purl.uniprot.org/uniprot/C1BH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100136252 ^@ http://purl.uniprot.org/uniprot/Q1M175 ^@ Subcellular Location Annotation ^@ dendrite http://togogenome.org/gene/8022:lhcgr ^@ http://purl.uniprot.org/uniprot/Q71MM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/8022:gnrh-r ^@ http://purl.uniprot.org/uniprot/Q9I986 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:LOC100136304 ^@ http://purl.uniprot.org/uniprot/Q3I346 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8022:tlr5m ^@ http://purl.uniprot.org/uniprot/Q68CI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8022:foxp3-2 ^@ http://purl.uniprot.org/uniprot/E4W7U5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:LOC100135920 ^@ http://purl.uniprot.org/uniprot/Q90ZD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/8022:ndkb ^@ http://purl.uniprot.org/uniprot/C1BIF8 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/8022:LOC100136136 ^@ http://purl.uniprot.org/uniprot/Q2YHL9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/8022:esr2a ^@ http://purl.uniprot.org/uniprot/Q0H7E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/8022:LOC100135998 ^@ http://purl.uniprot.org/uniprot/Q8QGB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8022:if6 ^@ http://purl.uniprot.org/uniprot/C1BFB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/8022:LOC100305243 ^@ http://purl.uniprot.org/uniprot/C1BHL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/8022:LOC100170202 ^@ http://purl.uniprot.org/uniprot/A0A060WE89|||http://purl.uniprot.org/uniprot/P26351 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/8022:LOC100335039 ^@ http://purl.uniprot.org/uniprot/A0A060XA34|||http://purl.uniprot.org/uniprot/P51467 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arrestin family.|||Cytoplasm http://togogenome.org/gene/8022:tk1 ^@ http://purl.uniprot.org/uniprot/C0KIP5 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/8022:LOC100136786 ^@ http://purl.uniprot.org/uniprot/P49843 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.|||Cytoplasm|||Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity).|||Isoform 1 is expressed in all tissues tested including liver, gills, intestine, skeletal muscle, kidney, heart, spleen, stomach, brain, pituitary, ovary, testis, skin and bladder. Isoform 2 is found only in testis.|||Mitochondrion|||Nucleus|||Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. May be dephosphorylated by PPP5C, attenuates NR3C1 action (By similarity).|||Receptor for glucocorticoids (GC) (PubMed:7649084, PubMed:8766708). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (By similarity). Affects inflammatory responses, cellular proliferation and differentiation in target tissues (By similarity). Involved in chromatin remodeling (By similarity). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (By similarity). May act as a tumor suppressor (By similarity). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).|||centrosome|||spindle http://togogenome.org/gene/8022:btg3 ^@ http://purl.uniprot.org/uniprot/C1BGU5 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8022:zgc:86839 ^@ http://purl.uniprot.org/uniprot/C1BGK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/8022:pou1f1 ^@ http://purl.uniprot.org/uniprot/Q08478 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-1 subfamily.|||Nucleus|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. http://togogenome.org/gene/8022:rs25 ^@ http://purl.uniprot.org/uniprot/C1BI45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/8022:stat1-1 ^@ http://purl.uniprot.org/uniprot/O13131 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:defb4 ^@ http://purl.uniprot.org/uniprot/C9WX71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/8022:LOC101268961 ^@ http://purl.uniprot.org/uniprot/L7Z8X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8022:tbca ^@ http://purl.uniprot.org/uniprot/C1BFK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/8022:atp1a2a ^@ http://purl.uniprot.org/uniprot/Q6VYM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8022:ucp2a ^@ http://purl.uniprot.org/uniprot/Q2PXW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8022:gh2 ^@ http://purl.uniprot.org/uniprot/P20332 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.|||Secreted http://togogenome.org/gene/8022:impa1 ^@ http://purl.uniprot.org/uniprot/C1BF75 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/8022:ddx4 ^@ http://purl.uniprot.org/uniprot/Q9PT10 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8022:nhe3 ^@ http://purl.uniprot.org/uniprot/A4GWV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Membrane http://togogenome.org/gene/8022:LOC100305219 ^@ http://purl.uniprot.org/uniprot/C1BHB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/8022:KEF44_p07 ^@ http://purl.uniprot.org/uniprot/P48172|||http://purl.uniprot.org/uniprot/Q1L035 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8022:eomesa ^@ http://purl.uniprot.org/uniprot/J9PYF5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8022:nfu1 ^@ http://purl.uniprot.org/uniprot/C1BGC1 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/8022:polr2j ^@ http://purl.uniprot.org/uniprot/C1BF62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/8022:om-ii ^@ http://purl.uniprot.org/uniprot/A0A060YJ16|||http://purl.uniprot.org/uniprot/P28771 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the ependymin family.|||Binds calcium through the terminal sialic acids.|||EPDs are synthesized in the meninx and secreted in the cerebrospinal fluid.|||May play a role in neural plasticity. May be involved during axon regeneration.|||Secreted http://togogenome.org/gene/8022:tpk1 ^@ http://purl.uniprot.org/uniprot/I3PU26 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/8022:lipea ^@ http://purl.uniprot.org/uniprot/E2JFF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||Cell membrane|||Lipid droplet|||caveola|||cytosol http://togogenome.org/gene/8022:rs14 ^@ http://purl.uniprot.org/uniprot/C1BGI0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/8022:stom ^@ http://purl.uniprot.org/uniprot/A6BLJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8022:LOC110521832 ^@ http://purl.uniprot.org/uniprot/A3EZK8 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Endoplasmic reticulum membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/8022:ifngamma2 ^@ http://purl.uniprot.org/uniprot/B6UQB7 ^@ Similarity ^@ Belongs to the type II (or gamma) interferon family. http://togogenome.org/gene/8022:polr2d ^@ http://purl.uniprot.org/uniprot/C1BFY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/8022:st8sia2 ^@ http://purl.uniprot.org/uniprot/A0PAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8022:LOC100136691 ^@ http://purl.uniprot.org/uniprot/Q09IZ1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8022:lbp/bpi-1 ^@ http://purl.uniprot.org/uniprot/Q8JFX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/8022:kitlg ^@ http://purl.uniprot.org/uniprot/H1ZRI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCF family.|||Cytoplasm|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/8022:gapdh ^@ http://purl.uniprot.org/uniprot/Q90ZF1 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/8022:LOC100136184 ^@ http://purl.uniprot.org/uniprot/Q6VYM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8022:impact ^@ http://purl.uniprot.org/uniprot/C1BER4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/8022:lect2 ^@ http://purl.uniprot.org/uniprot/Q8JJ67 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/8022:nduad ^@ http://purl.uniprot.org/uniprot/C1BF24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/8022:zgc:163057 ^@ http://purl.uniprot.org/uniprot/C1BEM8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8022:LOC100136335 ^@ http://purl.uniprot.org/uniprot/A0A060YTK5|||http://purl.uniprot.org/uniprot/Q20A00 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DDIT4 family.|||Cytoplasm|||Induced by LPS and zymosan in macrophages.|||Inhibits cell growth by regulating the TOR signaling pathway upstream of the tsc1-tsc2 complex and downstream of akt1. http://togogenome.org/gene/8022:csf-3 ^@ http://purl.uniprot.org/uniprot/D4YWD9 ^@ Similarity ^@ Belongs to the IL-6 superfamily. http://togogenome.org/gene/8022:LOC100136597 ^@ http://purl.uniprot.org/uniprot/Q800K1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/8022:m1ip1 ^@ http://purl.uniprot.org/uniprot/C1BGT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8022:fbxo25 ^@ http://purl.uniprot.org/uniprot/D9IV45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:adra1a ^@ http://purl.uniprot.org/uniprot/Q2VA56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8022:nkx2.1c ^@ http://purl.uniprot.org/uniprot/Q58A09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8022:ift122 ^@ http://purl.uniprot.org/uniprot/C1BH47 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/8022:lamp3 ^@ http://purl.uniprot.org/uniprot/I4EBR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/8022:praf3 ^@ http://purl.uniprot.org/uniprot/C1BHH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/8022:dazl ^@ http://purl.uniprot.org/uniprot/E9NQD4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8022:mrap ^@ http://purl.uniprot.org/uniprot/F4NAR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8022:abt1 ^@ http://purl.uniprot.org/uniprot/C1BHD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/8022:LOC101268957 ^@ http://purl.uniprot.org/uniprot/K7NAJ3 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Heterodimer with IFNAR2; forming the receptor for type I interferon.|||In the fibroblastic RTG-2 cell line, induced by polyinosine-polycytidylic acid (poly(I:C)), a synthetic analog of dsRNA, that binds TLR3.|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:24244163). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (By similarity). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (By similarity). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).|||perinuclear region http://togogenome.org/gene/8022:KEF44_p12 ^@ http://purl.uniprot.org/uniprot/P48175 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/8022:light ^@ http://purl.uniprot.org/uniprot/Q2I7F4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8022:hspb1 ^@ http://purl.uniprot.org/uniprot/Q4F877 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/8022:lyz2 ^@ http://purl.uniprot.org/uniprot/P11941 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has antibacterial activity against the Gram positive bacterium P.citreus. Has no antibacterial activity against the Gram negative bacteria E.coli and Y.ruckeri. Does not have hemolytic activity against trout erythrocytes.|||Secreted http://togogenome.org/gene/8022:LOC100305210 ^@ http://purl.uniprot.org/uniprot/C1BH68 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8022:nkx2.4a ^@ http://purl.uniprot.org/uniprot/Q58A07 ^@ Subcellular Location Annotation ^@ Nucleus