http://togogenome.org/gene/79929:MTBMA_RS07175 ^@ http://purl.uniprot.org/uniprot/D9PXV2 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/79929:MTBMA_RS08425 ^@ http://purl.uniprot.org/uniprot/D9PYJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/79929:MTBMA_RS06300 ^@ http://purl.uniprot.org/uniprot/D9PXD2 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/79929:MTBMA_RS03260 ^@ http://purl.uniprot.org/uniprot/D9PVK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06245 ^@ http://purl.uniprot.org/uniprot/D9PXC0 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/79929:MTBMA_RS08050 ^@ http://purl.uniprot.org/uniprot/D9PYC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0104 family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS00010 ^@ http://purl.uniprot.org/uniprot/D9PYR9 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/79929:MTBMA_RS02655 ^@ http://purl.uniprot.org/uniprot/D9PV84 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS00730 ^@ http://purl.uniprot.org/uniprot/Q50788 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Binds 1 [7Fe-Mo-9S-C-homocitryl] cluster per subunit.|||Binds 1 [8Fe-7S] cluster per heterodimer.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/79929:MTBMA_RS01175 ^@ http://purl.uniprot.org/uniprot/P26920 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/79929:MTBMA_RS03795 ^@ http://purl.uniprot.org/uniprot/D9PVW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS04020 ^@ http://purl.uniprot.org/uniprot/D9PW15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS07720 ^@ http://purl.uniprot.org/uniprot/D9PY63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS04840 ^@ http://purl.uniprot.org/uniprot/D9PWI5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS01075 ^@ http://purl.uniprot.org/uniprot/D9PUC9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/79929:MTBMA_RS00150 ^@ http://purl.uniprot.org/uniprot/D9PYU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/79929:MTBMA_RS03570 ^@ http://purl.uniprot.org/uniprot/D9PVS3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/79929:MTBMA_RS00205 ^@ http://purl.uniprot.org/uniprot/D9PYV6 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS00905 ^@ http://purl.uniprot.org/uniprot/D9PU94 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS05875 ^@ http://purl.uniprot.org/uniprot/D9PX46 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/79929:MTBMA_RS08390 ^@ http://purl.uniprot.org/uniprot/D9PYI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/79929:MTBMA_RS03435 ^@ http://purl.uniprot.org/uniprot/D9PVP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F420-dependent NADP reductase family.|||Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS04250 ^@ http://purl.uniprot.org/uniprot/D9PW64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Dps family.|||Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.|||Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.|||nucleoid http://togogenome.org/gene/79929:MTBMA_RS08350 ^@ http://purl.uniprot.org/uniprot/D9PYI0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/79929:MTBMA_RS03480 ^@ http://purl.uniprot.org/uniprot/D9PVQ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/79929:MTBMA_RS04720 ^@ http://purl.uniprot.org/uniprot/D9PWG1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS02640 ^@ http://purl.uniprot.org/uniprot/D9PV81 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/79929:MTBMA_RS03670 ^@ http://purl.uniprot.org/uniprot/D9PVU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS02535 ^@ http://purl.uniprot.org/uniprot/D9PV62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS01010 ^@ http://purl.uniprot.org/uniprot/D9PUB6 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/79929:MTBMA_RS02445 ^@ http://purl.uniprot.org/uniprot/D9PV44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/79929:MTBMA_RS05450 ^@ http://purl.uniprot.org/uniprot/D9PWW4 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/79929:MTBMA_RS06870 ^@ http://purl.uniprot.org/uniprot/D9PXP5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS03270 ^@ http://purl.uniprot.org/uniprot/D9PVL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07405 ^@ http://purl.uniprot.org/uniprot/P60239 ^@ Function|||Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Part of a complex that provides reducing equivalents for heterodisulfide reductase.|||The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr). http://togogenome.org/gene/79929:MTBMA_RS04650 ^@ http://purl.uniprot.org/uniprot/D9PWE7 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/79929:MTBMA_RS09025 ^@ http://purl.uniprot.org/uniprot/P80186 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrE family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.|||The first gene of the probable mtrEDCBAFGH operon. http://togogenome.org/gene/79929:MTBMA_RS05140 ^@ http://purl.uniprot.org/uniprot/D9PWP7 ^@ Similarity ^@ Belongs to the HisA/HisF family. http://togogenome.org/gene/79929:MTBMA_RS08755 ^@ http://purl.uniprot.org/uniprot/D9PYR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/79929:MTBMA_RS05685 ^@ http://purl.uniprot.org/uniprot/D9PX11 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/79929:MTBMA_RS01675 ^@ http://purl.uniprot.org/uniprot/D9PUP3 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.|||Has ATPase and non-specific DNA-binding activities. http://togogenome.org/gene/79929:MTBMA_RS01755 ^@ http://purl.uniprot.org/uniprot/D9PUQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS01040 ^@ http://purl.uniprot.org/uniprot/D9PUC2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/79929:MTBMA_RS03305 ^@ http://purl.uniprot.org/uniprot/D9PVL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.|||Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS06735 ^@ http://purl.uniprot.org/uniprot/D9PXL8 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS00740 ^@ http://purl.uniprot.org/uniprot/P95297 ^@ Function|||Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family.|||This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor). http://togogenome.org/gene/79929:MTBMA_RS07690 ^@ http://purl.uniprot.org/uniprot/D9PY57 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofG family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/79929:MTBMA_RS01045 ^@ http://purl.uniprot.org/uniprot/D9PUC3 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/79929:MTBMA_RS07355 ^@ http://purl.uniprot.org/uniprot/D9PXY9 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/79929:MTBMA_RS02335 ^@ http://purl.uniprot.org/uniprot/D9PV22 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/79929:MTBMA_RS05705 ^@ http://purl.uniprot.org/uniprot/P80305 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.|||Cytoplasm|||May catalyze the biosynthesis of dTMP using an unknown cosubstrate. In vitro, also catalyzes the dehalogenation of 5-bromo-deoxyuridine monophosphate (Br-dUMP) and the tritium exchange of [5-3H]deoxyuridine monophosphate ([5-3H]dUMP).|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS01385 ^@ http://purl.uniprot.org/uniprot/D9PUJ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS02480 ^@ http://purl.uniprot.org/uniprot/D9PV51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS07315 ^@ http://purl.uniprot.org/uniprot/D9PXY1 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. http://togogenome.org/gene/79929:MTBMA_RS01365 ^@ http://purl.uniprot.org/uniprot/D9PUI8 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/79929:MTBMA_RS00900 ^@ http://purl.uniprot.org/uniprot/D9PU93 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS04265 ^@ http://purl.uniprot.org/uniprot/D9PW69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS04545 ^@ http://purl.uniprot.org/uniprot/D9PWC5 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/79929:MTBMA_RS01405 ^@ http://purl.uniprot.org/uniprot/D9PUJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06880 ^@ http://purl.uniprot.org/uniprot/D9PXP7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/79929:MTBMA_RS02430 ^@ http://purl.uniprot.org/uniprot/D9PV41 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/79929:MTBMA_RS05865 ^@ http://purl.uniprot.org/uniprot/D9PX44 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/79929:MTBMA_RS08660 ^@ http://purl.uniprot.org/uniprot/D9PYP3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS07130 ^@ http://purl.uniprot.org/uniprot/D9PXU1 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/79929:MTBMA_RS07790 ^@ http://purl.uniprot.org/uniprot/D9PY78 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/79929:MTBMA_RS04690 ^@ http://purl.uniprot.org/uniprot/D9PWF5 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/79929:MTBMA_RS00980 ^@ http://purl.uniprot.org/uniprot/D9PUB0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/79929:MTBMA_RS05755 ^@ http://purl.uniprot.org/uniprot/D9PX24 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/79929:MTBMA_RS06785 ^@ http://purl.uniprot.org/uniprot/D9PXM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/79929:MTBMA_RS03730 ^@ http://purl.uniprot.org/uniprot/D9PVV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS01395 ^@ http://purl.uniprot.org/uniprot/D9PUJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06770 ^@ http://purl.uniprot.org/uniprot/D9PXM5 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/79929:MTBMA_RS00910 ^@ http://purl.uniprot.org/uniprot/D9PU95 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/79929:MTBMA_RS08630 ^@ http://purl.uniprot.org/uniprot/P50436 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS01730 ^@ http://purl.uniprot.org/uniprot/D9PUQ4 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/79929:MTBMA_RS07280 ^@ http://purl.uniprot.org/uniprot/D9PXX4 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/79929:MTBMA_RS04905 ^@ http://purl.uniprot.org/uniprot/D9PWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS02285 ^@ http://purl.uniprot.org/uniprot/D9PV12 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/79929:MTBMA_RS06565 ^@ http://purl.uniprot.org/uniprot/D9PXI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS06280 ^@ http://purl.uniprot.org/uniprot/D9PXC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/79929:MTBMA_RS06205 ^@ http://purl.uniprot.org/uniprot/D9PXB2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/79929:MTBMA_RS01530 ^@ http://purl.uniprot.org/uniprot/D9PUL8 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/79929:MTBMA_RS05325 ^@ http://purl.uniprot.org/uniprot/P80909 ^@ Cofactor|||Subunit ^@ Binds 2 [4Fe-4S] clusters.|||Heterotrimer of the VorA, VorB and VorC subunits. http://togogenome.org/gene/79929:MTBMA_RS02685 ^@ http://purl.uniprot.org/uniprot/D9PV90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.|||Homodimer.|||Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate. http://togogenome.org/gene/79929:MTBMA_RS04625 ^@ http://purl.uniprot.org/uniprot/D9PWE1 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/79929:MTBMA_RS02910 ^@ http://purl.uniprot.org/uniprot/D9PVD9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/79929:MTBMA_RS02610 ^@ http://purl.uniprot.org/uniprot/D9PV76 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/79929:MTBMA_RS04845 ^@ http://purl.uniprot.org/uniprot/D9PWI6 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/79929:MTBMA_RS01030 ^@ http://purl.uniprot.org/uniprot/D9PUC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS08645 ^@ http://purl.uniprot.org/uniprot/D9PYP0 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/79929:MTBMA_RS04080 ^@ http://purl.uniprot.org/uniprot/D9PW27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS07555 ^@ http://purl.uniprot.org/uniprot/P11562 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:3350018, PubMed:9367957). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (PubMed:9030728).|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018). Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).|||Cytoplasm|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.|||Methyl-coenzyme M reductase activity is inhibited by 3-nitrooxypropanol (3-NOP) in vitro and in vivo, by oxidation of its active site Ni(I), which stops both growth and methanogenesis (PubMed:27140643). Is also inhibited by the reaction product CoM-S-S-CoB (PubMed:3350018).|||The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS02510 ^@ http://purl.uniprot.org/uniprot/D9PV57 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/79929:MTBMA_RS05700 ^@ http://purl.uniprot.org/uniprot/P51616 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS02635 ^@ http://purl.uniprot.org/uniprot/D9PV80 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/79929:MTBMA_RS03460 ^@ http://purl.uniprot.org/uniprot/D9PVQ0 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/79929:MTBMA_RS01335 ^@ http://purl.uniprot.org/uniprot/D9PUI2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/79929:MTBMA_RS02325 ^@ http://purl.uniprot.org/uniprot/D9PV20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06885 ^@ http://purl.uniprot.org/uniprot/D9PXP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS00085 ^@ http://purl.uniprot.org/uniprot/D9PYT4 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/79929:MTBMA_RS03565 ^@ http://purl.uniprot.org/uniprot/D9PVS2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/79929:MTBMA_RS07045 ^@ http://purl.uniprot.org/uniprot/D9PXS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS00055 ^@ http://purl.uniprot.org/uniprot/D9PYS8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS06550 ^@ http://purl.uniprot.org/uniprot/D9PXI1 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/79929:MTBMA_RS00930 ^@ http://purl.uniprot.org/uniprot/D9PUA0 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/79929:MTBMA_RS02490 ^@ http://purl.uniprot.org/uniprot/D9PV53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/79929:MTBMA_RS02300 ^@ http://purl.uniprot.org/uniprot/D9PV15 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/79929:MTBMA_RS01555 ^@ http://purl.uniprot.org/uniprot/P80903 ^@ Cofactor|||Subunit ^@ Binds 2 [4Fe-4S] clusters.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/79929:MTBMA_RS05190 ^@ http://purl.uniprot.org/uniprot/D9PWQ9 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/79929:MTBMA_RS00315 ^@ http://purl.uniprot.org/uniprot/D9PTX5 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/79929:MTBMA_RS07500 ^@ http://purl.uniprot.org/uniprot/Q50777 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/79929:MTBMA_RS03825 ^@ http://purl.uniprot.org/uniprot/D9PVX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06290 ^@ http://purl.uniprot.org/uniprot/D9PXD0 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. http://togogenome.org/gene/79929:MTBMA_RS06850 ^@ http://purl.uniprot.org/uniprot/D9PXP1 ^@ Function|||Similarity ^@ Belongs to the archaeal IMP cyclohydrolase family.|||Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. http://togogenome.org/gene/79929:MTBMA_RS06535 ^@ http://purl.uniprot.org/uniprot/D9PXH8 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/79929:MTBMA_RS05670 ^@ http://purl.uniprot.org/uniprot/D9PX07 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/79929:MTBMA_RS00810 ^@ http://purl.uniprot.org/uniprot/D9PU75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ferredoxin thioredoxin reductase beta subunit family.|||Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.|||Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin. http://togogenome.org/gene/79929:MTBMA_RS06370 ^@ http://purl.uniprot.org/uniprot/P61937 ^@ Activity Regulation|||Function|||Induction|||Similarity|||Subunit ^@ By growth on molybdenum, under anaerobic conditions.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile.|||Consists of five subunits; FmdA, FmdB, FmdC, FmdD, and FmdE.|||In the C-terminal section; belongs to the molybdenum dinucleotide binding protein family.|||In the N-terminal section; belongs to the FwdC/FmdC family.|||Inactivated by cyanide. http://togogenome.org/gene/79929:MTBMA_RS06775 ^@ http://purl.uniprot.org/uniprot/D9PXM6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/79929:MTBMA_RS05475 ^@ http://purl.uniprot.org/uniprot/D9PWW9 ^@ Similarity ^@ Belongs to the UPF0280 family. http://togogenome.org/gene/79929:MTBMA_RS05150 ^@ http://purl.uniprot.org/uniprot/D9PWP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS03045 ^@ http://purl.uniprot.org/uniprot/D9PVG6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/79929:MTBMA_RS02860 ^@ http://purl.uniprot.org/uniprot/D9PVC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS08150 ^@ http://purl.uniprot.org/uniprot/D9PYE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS06160 ^@ http://purl.uniprot.org/uniprot/D9PXA3 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/79929:MTBMA_RS06585 ^@ http://purl.uniprot.org/uniprot/D9PXI8 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/79929:MTBMA_RS05940 ^@ http://purl.uniprot.org/uniprot/D9PX60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS03520 ^@ http://purl.uniprot.org/uniprot/D9PVR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/79929:MTBMA_RS00880 ^@ http://purl.uniprot.org/uniprot/D9PU89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS03100 ^@ http://purl.uniprot.org/uniprot/P0C0K9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/79929:MTBMA_RS07635 ^@ http://purl.uniprot.org/uniprot/D9PY45 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/79929:MTBMA_RS00230 ^@ http://purl.uniprot.org/uniprot/D9PYW1 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/79929:MTBMA_RS07035 ^@ http://purl.uniprot.org/uniprot/D9PXS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/79929:MTBMA_RS01330 ^@ http://purl.uniprot.org/uniprot/D9PUI1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. http://togogenome.org/gene/79929:MTBMA_RS05795 ^@ http://purl.uniprot.org/uniprot/D9PX30 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/79929:MTBMA_RS08705 ^@ http://purl.uniprot.org/uniprot/D9PYQ2 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/79929:MTBMA_RS08180 ^@ http://purl.uniprot.org/uniprot/D9PYE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/79929:MTBMA_RS05615 ^@ http://purl.uniprot.org/uniprot/D9PWZ6 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/79929:MTBMA_RS06270 ^@ http://purl.uniprot.org/uniprot/D9PXC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/79929:MTBMA_RS01760 ^@ http://purl.uniprot.org/uniprot/D9PUQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS01795 ^@ http://purl.uniprot.org/uniprot/D9PUR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS06665 ^@ http://purl.uniprot.org/uniprot/D9PXK4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS02080 ^@ http://purl.uniprot.org/uniprot/D9PUX5 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds 1 [2Fe-2S] cluster per subunit.|||Binds 2 [4Fe-4S] clusters per subunit.|||Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.|||Cytoplasm|||Subunit B of the heterodimeric fumarate reductase of methanogenic Archaea, composed of subunits A (TfrA) and B (TfrB). http://togogenome.org/gene/79929:MTBMA_RS08775 ^@ http://purl.uniprot.org/uniprot/D9PYR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS00720 ^@ http://purl.uniprot.org/uniprot/Q50786 ^@ Function|||Similarity ^@ Belongs to the P(II) protein family.|||Could be involved in the regulation of nitrogen fixation. http://togogenome.org/gene/79929:MTBMA_RS06385 ^@ http://purl.uniprot.org/uniprot/D9PXE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07005 ^@ http://purl.uniprot.org/uniprot/D9PXR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS00060 ^@ http://purl.uniprot.org/uniprot/D9PYS9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/79929:MTBMA_RS05125 ^@ http://purl.uniprot.org/uniprot/D9PWP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/79929:MTBMA_RS02650 ^@ http://purl.uniprot.org/uniprot/D9PV83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS03475 ^@ http://purl.uniprot.org/uniprot/D9PVQ3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/79929:MTBMA_RS02665 ^@ http://purl.uniprot.org/uniprot/Q53479 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FPP/GGPP synthase family.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS00420 ^@ http://purl.uniprot.org/uniprot/D9PTZ7 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS04750 ^@ http://purl.uniprot.org/uniprot/D9PWG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS04665 ^@ http://purl.uniprot.org/uniprot/D9PWF0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS04395 ^@ http://purl.uniprot.org/uniprot/D9PW95 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/79929:MTBMA_RS05235 ^@ http://purl.uniprot.org/uniprot/D9PWR8 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/79929:MTBMA_RS02150 ^@ http://purl.uniprot.org/uniprot/D9PUZ0 ^@ Similarity ^@ Belongs to the UPF0288 family. http://togogenome.org/gene/79929:MTBMA_RS02595 ^@ http://purl.uniprot.org/uniprot/D9PV73 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS05260 ^@ http://purl.uniprot.org/uniprot/D9PWS3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/79929:MTBMA_RS03640 ^@ http://purl.uniprot.org/uniprot/D9PVT8 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/79929:MTBMA_RS06360 ^@ http://purl.uniprot.org/uniprot/P56811 ^@ Function|||Similarity ^@ Belongs to the Tfx family.|||Transcriptional activator of the fmdECB operon. http://togogenome.org/gene/79929:MTBMA_RS06920 ^@ http://purl.uniprot.org/uniprot/P80905 ^@ Subunit ^@ Heterotetramer of the KorA, KorB, KorC and KorD subunits. http://togogenome.org/gene/79929:MTBMA_RS02600 ^@ http://purl.uniprot.org/uniprot/D9PV74 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/79929:MTBMA_RS04610 ^@ http://purl.uniprot.org/uniprot/P0C882 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Homopentamer.|||Inhibited by EDTA in vitro.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Cannot use sn-glycerol-3-phosphate (G3P) or dihydroxyacetonephosphate (DHAP) as substrate. http://togogenome.org/gene/79929:MTBMA_RS08700 ^@ http://purl.uniprot.org/uniprot/D9PYQ1 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/79929:MTBMA_RS01150 ^@ http://purl.uniprot.org/uniprot/P26940 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Binds 1 Mg(2+) ion per subunit.|||Feedback inhibited by tryptophan.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). http://togogenome.org/gene/79929:MTBMA_RS07080 ^@ http://purl.uniprot.org/uniprot/D9PXT1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS02605 ^@ http://purl.uniprot.org/uniprot/D9PV75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/79929:MTBMA_RS06215 ^@ http://purl.uniprot.org/uniprot/D9PXB4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS00325 ^@ http://purl.uniprot.org/uniprot/D9PTX7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS01985 ^@ http://purl.uniprot.org/uniprot/D9PUV5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/79929:MTBMA_RS07560 ^@ http://purl.uniprot.org/uniprot/P11566 ^@ Developmental Stage|||Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS08000 ^@ http://purl.uniprot.org/uniprot/D9PYB9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS01090 ^@ http://purl.uniprot.org/uniprot/D9PUD2 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. http://togogenome.org/gene/79929:MTBMA_RS08605 ^@ http://purl.uniprot.org/uniprot/P26499 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS00675 ^@ http://purl.uniprot.org/uniprot/D9PU49 ^@ Similarity ^@ In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/79929:MTBMA_RS08640 ^@ http://purl.uniprot.org/uniprot/D9PYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS05280 ^@ http://purl.uniprot.org/uniprot/D9PWS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS00710 ^@ http://purl.uniprot.org/uniprot/D9PU56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/79929:MTBMA_RS02420 ^@ http://purl.uniprot.org/uniprot/D9PV39 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/79929:MTBMA_RS07700 ^@ http://purl.uniprot.org/uniprot/D9PY59 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/79929:MTBMA_RS05275 ^@ http://purl.uniprot.org/uniprot/D9PWS6 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/79929:MTBMA_RS08170 ^@ http://purl.uniprot.org/uniprot/D9PYE7 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/79929:MTBMA_RS07125 ^@ http://purl.uniprot.org/uniprot/D9PXU0 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/79929:MTBMA_RS04115 ^@ http://purl.uniprot.org/uniprot/D9PW34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/79929:MTBMA_RS06285 ^@ http://purl.uniprot.org/uniprot/D9PXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS03530 ^@ http://purl.uniprot.org/uniprot/D9PVR4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/79929:MTBMA_RS05290 ^@ http://purl.uniprot.org/uniprot/D9PWS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS05575 ^@ http://purl.uniprot.org/uniprot/D9PWY9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/79929:MTBMA_RS07515 ^@ http://purl.uniprot.org/uniprot/Q50774 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrG family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||Part of the probable mtrEDCBAFGH operon.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS08400 ^@ http://purl.uniprot.org/uniprot/D9PYJ0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/79929:MTBMA_RS00285 ^@ http://purl.uniprot.org/uniprot/D9PTW9 ^@ Function|||Similarity ^@ Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.|||Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.|||In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.|||In the N-terminal section; belongs to the formaldehyde-activating enzyme family. http://togogenome.org/gene/79929:MTBMA_RS05455 ^@ http://purl.uniprot.org/uniprot/D9PWW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS05040 ^@ http://purl.uniprot.org/uniprot/D9PWM5 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/79929:MTBMA_RS00430 ^@ http://purl.uniprot.org/uniprot/D9PU00 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-dependent oxidoreductase 2 family.|||Binds 1 flavin covalently per subunit.|||Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.|||Cytoplasm|||Subunit A of the heterodimeric fumarate reductase of methanogenic Archaea, composed of subunits A (TfrA) and B (TfrB). http://togogenome.org/gene/79929:MTBMA_RS08315 ^@ http://purl.uniprot.org/uniprot/D9PYH3 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/79929:MTBMA_RS06455 ^@ http://purl.uniprot.org/uniprot/D9PXG2 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/79929:MTBMA_RS06250 ^@ http://purl.uniprot.org/uniprot/D9PXC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0104 family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07640 ^@ http://purl.uniprot.org/uniprot/D9PY46 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/79929:MTBMA_RS02590 ^@ http://purl.uniprot.org/uniprot/D9PV72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS08020 ^@ http://purl.uniprot.org/uniprot/D9PYC3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS05100 ^@ http://purl.uniprot.org/uniprot/D9PWN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS02280 ^@ http://purl.uniprot.org/uniprot/D9PV11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS00920 ^@ http://purl.uniprot.org/uniprot/D9PU98 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/79929:MTBMA_RS06540 ^@ http://purl.uniprot.org/uniprot/D9PXH9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/79929:MTBMA_RS00855 ^@ http://purl.uniprot.org/uniprot/D9PU84 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/79929:MTBMA_RS09115 ^@ http://purl.uniprot.org/uniprot/D9PYB7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS02370 ^@ http://purl.uniprot.org/uniprot/D9PV29 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/79929:MTBMA_RS05015 ^@ http://purl.uniprot.org/uniprot/D9PWL9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-94 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/79929:MTBMA_RS01500 ^@ http://purl.uniprot.org/uniprot/D9PUL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS05750 ^@ http://purl.uniprot.org/uniprot/D9PX23 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/79929:MTBMA_RS02850 ^@ http://purl.uniprot.org/uniprot/D9PVC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiM family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Membrane|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/79929:MTBMA_RS03155 ^@ http://purl.uniprot.org/uniprot/D9PVI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/79929:MTBMA_RS02240 ^@ http://purl.uniprot.org/uniprot/D9PV08 ^@ Function|||Similarity ^@ Belongs to the 2-phosphoglycerate kinase family.|||Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. http://togogenome.org/gene/79929:MTBMA_RS04990 ^@ http://purl.uniprot.org/uniprot/D9PWL6 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/79929:MTBMA_RS08190 ^@ http://purl.uniprot.org/uniprot/D9PYF1 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/79929:MTBMA_RS02250 ^@ http://purl.uniprot.org/uniprot/D9PV10 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/79929:MTBMA_RS05845 ^@ http://purl.uniprot.org/uniprot/D9PX40 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/79929:MTBMA_RS00960 ^@ http://purl.uniprot.org/uniprot/D9PUA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/79929:MTBMA_RS01690 ^@ http://purl.uniprot.org/uniprot/D9PUP6 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/79929:MTBMA_RS07135 ^@ http://purl.uniprot.org/uniprot/D9PXU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS00145 ^@ http://purl.uniprot.org/uniprot/D9PYU4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS02125 ^@ http://purl.uniprot.org/uniprot/D9PUY4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS01915 ^@ http://purl.uniprot.org/uniprot/D9PUU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS00180 ^@ http://purl.uniprot.org/uniprot/D9PYV1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS01260 ^@ http://purl.uniprot.org/uniprot/D9PUG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/79929:MTBMA_RS05345 ^@ http://purl.uniprot.org/uniprot/D9PWU1 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/79929:MTBMA_RS05970 ^@ http://purl.uniprot.org/uniprot/D9PX65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS01520 ^@ http://purl.uniprot.org/uniprot/D9PUL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/79929:MTBMA_RS08345 ^@ http://purl.uniprot.org/uniprot/D9PYH9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/79929:MTBMA_RS05110 ^@ http://purl.uniprot.org/uniprot/D9PWP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS05985 ^@ http://purl.uniprot.org/uniprot/D9PX68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS03465 ^@ http://purl.uniprot.org/uniprot/D9PVQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS01430 ^@ http://purl.uniprot.org/uniprot/D9PUK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhD family.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. http://togogenome.org/gene/79929:MTBMA_RS00345 ^@ http://purl.uniprot.org/uniprot/D9PTY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS01890 ^@ http://purl.uniprot.org/uniprot/D9PUT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/79929:MTBMA_RS06865 ^@ http://purl.uniprot.org/uniprot/D9PXP4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/79929:MTBMA_RS07255 ^@ http://purl.uniprot.org/uniprot/D9PXW9 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/79929:MTBMA_RS05835 ^@ http://purl.uniprot.org/uniprot/D9PX38 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/79929:MTBMA_RS00070 ^@ http://purl.uniprot.org/uniprot/D9PYT1 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/79929:MTBMA_RS08325 ^@ http://purl.uniprot.org/uniprot/D9PYH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/79929:MTBMA_RS01495 ^@ http://purl.uniprot.org/uniprot/D9PUL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/79929:MTBMA_RS04590 ^@ http://purl.uniprot.org/uniprot/D9PWD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06150 ^@ http://purl.uniprot.org/uniprot/D9PXA1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/79929:MTBMA_RS06080 ^@ http://purl.uniprot.org/uniprot/D9PX87 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/79929:MTBMA_RS07530 ^@ http://purl.uniprot.org/uniprot/Q59584 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrB family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||Part of the probable mtrEDCBAFGH operon.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS02060 ^@ http://purl.uniprot.org/uniprot/D9PUX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer. http://togogenome.org/gene/79929:MTBMA_RS06790 ^@ http://purl.uniprot.org/uniprot/D9PXM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/79929:MTBMA_RS00460 ^@ http://purl.uniprot.org/uniprot/D9PU06 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/79929:MTBMA_RS05880 ^@ http://purl.uniprot.org/uniprot/D9PX47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/79929:MTBMA_RS03095 ^@ http://purl.uniprot.org/uniprot/D9PVH6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/79929:MTBMA_RS05830 ^@ http://purl.uniprot.org/uniprot/D9PX37 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS06170 ^@ http://purl.uniprot.org/uniprot/D9PXA5 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/79929:MTBMA_RS01725 ^@ http://purl.uniprot.org/uniprot/D9PUQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS05365 ^@ http://purl.uniprot.org/uniprot/D9PWU6 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/79929:MTBMA_RS03350 ^@ http://purl.uniprot.org/uniprot/D9PVM8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS07025 ^@ http://purl.uniprot.org/uniprot/D9PXS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS02220 ^@ http://purl.uniprot.org/uniprot/Q50755 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrB family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase. http://togogenome.org/gene/79929:MTBMA_RS01180 ^@ http://purl.uniprot.org/uniprot/P26925 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||It is uncertain whether Met-1, Met-7 or Met-11 is the initiator. http://togogenome.org/gene/79929:MTBMA_RS01060 ^@ http://purl.uniprot.org/uniprot/D9PUC6 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/79929:MTBMA_RS07010 ^@ http://purl.uniprot.org/uniprot/D9PXS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS06795 ^@ http://purl.uniprot.org/uniprot/D9PXN0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS03225 ^@ http://purl.uniprot.org/uniprot/D9PVK2 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/79929:MTBMA_RS02615 ^@ http://purl.uniprot.org/uniprot/D9PV77 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS02475 ^@ http://purl.uniprot.org/uniprot/D9PV50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/79929:MTBMA_RS07795 ^@ http://purl.uniprot.org/uniprot/D9PY79 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS02645 ^@ http://purl.uniprot.org/uniprot/D9PV82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS02855 ^@ http://purl.uniprot.org/uniprot/Q50799 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiN family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/79929:MTBMA_RS07810 ^@ http://purl.uniprot.org/uniprot/D9PY82 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS03535 ^@ http://purl.uniprot.org/uniprot/D9PVR5 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS03485 ^@ http://purl.uniprot.org/uniprot/D9PVQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/79929:MTBMA_RS02465 ^@ http://purl.uniprot.org/uniprot/D9PV48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/79929:MTBMA_RS06015 ^@ http://purl.uniprot.org/uniprot/D9PX74 ^@ Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homotetramer; probably dimer of dimers. http://togogenome.org/gene/79929:MTBMA_RS02075 ^@ http://purl.uniprot.org/uniprot/D9PUX4 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/79929:MTBMA_RS06600 ^@ http://purl.uniprot.org/uniprot/D9PXJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS02485 ^@ http://purl.uniprot.org/uniprot/D9PV52 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/79929:MTBMA_RS04615 ^@ http://purl.uniprot.org/uniprot/D9PWD9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/79929:MTBMA_RS07590 ^@ http://purl.uniprot.org/uniprot/D9PY36 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/79929:MTBMA_RS02310 ^@ http://purl.uniprot.org/uniprot/D9PV17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07390 ^@ http://purl.uniprot.org/uniprot/D9PXZ6 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS02550 ^@ http://purl.uniprot.org/uniprot/D9PV65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS04385 ^@ http://purl.uniprot.org/uniprot/D9PW93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS07365 ^@ http://purl.uniprot.org/uniprot/D9PXZ1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/79929:MTBMA_RS02450 ^@ http://purl.uniprot.org/uniprot/D9PV45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS02440 ^@ http://purl.uniprot.org/uniprot/D9PV43 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/79929:MTBMA_RS05340 ^@ http://purl.uniprot.org/uniprot/D9PWU0 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/79929:MTBMA_RS07705 ^@ http://purl.uniprot.org/uniprot/D9PY60 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/79929:MTBMA_RS04380 ^@ http://purl.uniprot.org/uniprot/D9PW92 ^@ Similarity ^@ Belongs to the HMD family. http://togogenome.org/gene/79929:MTBMA_RS04075 ^@ http://purl.uniprot.org/uniprot/D9PW26 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/79929:MTBMA_RS05770 ^@ http://purl.uniprot.org/uniprot/D9PX27 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/79929:MTBMA_RS06655 ^@ http://purl.uniprot.org/uniprot/D9PXK2 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS04865 ^@ http://purl.uniprot.org/uniprot/D9PWJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS01200 ^@ http://purl.uniprot.org/uniprot/D9PUF4 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/79929:MTBMA_RS00415 ^@ http://purl.uniprot.org/uniprot/D9PTZ6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS00550 ^@ http://purl.uniprot.org/uniprot/D9PU23 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/79929:MTBMA_RS05200 ^@ http://purl.uniprot.org/uniprot/D9PWR1 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/79929:MTBMA_RS00770 ^@ http://purl.uniprot.org/uniprot/D9PU68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS00445 ^@ http://purl.uniprot.org/uniprot/D9PU03 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/79929:MTBMA_RS06030 ^@ http://purl.uniprot.org/uniprot/D9PX77 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS07305 ^@ http://purl.uniprot.org/uniprot/D9PXX9 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS01345 ^@ http://purl.uniprot.org/uniprot/D9PUI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS07910 ^@ http://purl.uniprot.org/uniprot/D9PYA1 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/79929:MTBMA_RS00155 ^@ http://purl.uniprot.org/uniprot/D9PYU6 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/79929:MTBMA_RS00590 ^@ http://purl.uniprot.org/uniprot/D9PU32 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/79929:MTBMA_RS08215 ^@ http://purl.uniprot.org/uniprot/D9PYF5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/79929:MTBMA_RS04715 ^@ http://purl.uniprot.org/uniprot/D9PWG0 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/79929:MTBMA_RS06555 ^@ http://purl.uniprot.org/uniprot/D9PXI2 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/79929:MTBMA_RS07040 ^@ http://purl.uniprot.org/uniprot/D9PXS6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/79929:MTBMA_RS06330 ^@ http://purl.uniprot.org/uniprot/P58818 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-2 family.|||Binds 1 F420 non-covalently per subunit. The F420 is in its oxidized state.|||Binds 1 FAD. The FAD is in its reduced state.|||Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. http://togogenome.org/gene/79929:MTBMA_RS08610 ^@ http://purl.uniprot.org/uniprot/P26498 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/79929:MTBMA_RS05995 ^@ http://purl.uniprot.org/uniprot/D9PX70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/79929:MTBMA_RS03040 ^@ http://purl.uniprot.org/uniprot/D9PVG5 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/79929:MTBMA_RS08225 ^@ http://purl.uniprot.org/uniprot/D9PYF7 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/79929:MTBMA_RS08185 ^@ http://purl.uniprot.org/uniprot/D9PYF0 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/79929:MTBMA_RS01065 ^@ http://purl.uniprot.org/uniprot/D9PUC7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/79929:MTBMA_RS05870 ^@ http://purl.uniprot.org/uniprot/P42035 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutaredoxin family.|||Cytoplasm|||Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. May be a component of a ribonucleotide-reducing system distinct from the previously described systems utilizing thioredoxin or glutaredoxin. http://togogenome.org/gene/79929:MTBMA_RS08765 ^@ http://purl.uniprot.org/uniprot/D9PYR4 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/79929:MTBMA_RS08760 ^@ http://purl.uniprot.org/uniprot/D9PYR3 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS07440 ^@ http://purl.uniprot.org/uniprot/P32440 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Activity requires salt; 100 mM sodium or potassium salts of chloride, phosphate or sulfate are equally effective. Inactivated by O(2).|||Belongs to the HMD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS03400 ^@ http://purl.uniprot.org/uniprot/D9PVN8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/79929:MTBMA_RS02530 ^@ http://purl.uniprot.org/uniprot/D9PV61 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS04700 ^@ http://purl.uniprot.org/uniprot/D9PWF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/79929:MTBMA_RS07565 ^@ http://purl.uniprot.org/uniprot/P11564 ^@ Developmental Stage|||Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS08340 ^@ http://purl.uniprot.org/uniprot/D9PYH8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/79929:MTBMA_RS06060 ^@ http://purl.uniprot.org/uniprot/D9PX83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS00630 ^@ http://purl.uniprot.org/uniprot/D9PU40 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS02845 ^@ http://purl.uniprot.org/uniprot/D9PVC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS03940 ^@ http://purl.uniprot.org/uniprot/Q9P9J4 ^@ Similarity ^@ Belongs to the FTR family. http://togogenome.org/gene/79929:MTBMA_RS00250 ^@ http://purl.uniprot.org/uniprot/P55300 ^@ Activity Regulation|||Function|||Induction|||Similarity|||Subunit ^@ Activity requires salt; 100 mM sodium or potassium salts of chloride, phosphate or sulfate are equally effective. Not inactivated by O(2). Inhibited by hydrogen-producing 5,10-methenyltetrahydromethanopterin hydrogenase which has a higher affinity for their shared substrate (PubMed:1765081). Enzyme is O(2)-stable and strictly dependent on coenzyme F420 (PubMed:7852356).|||Belongs to the MTD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.|||Enzyme activity is not detectable when grown anaerobically.|||Found to be tightly associated with methyl-coenzyme M methylreductase. http://togogenome.org/gene/79929:MTBMA_RS07650 ^@ http://purl.uniprot.org/uniprot/D9PY48 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/79929:MTBMA_RS08090 ^@ http://purl.uniprot.org/uniprot/D9PYD6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS00165 ^@ http://purl.uniprot.org/uniprot/D9PYU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS03440 ^@ http://purl.uniprot.org/uniprot/D9PVP6 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/79929:MTBMA_RS07105 ^@ http://purl.uniprot.org/uniprot/D9PXT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/79929:MTBMA_RS03005 ^@ http://purl.uniprot.org/uniprot/Q60036 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Binds 1 Fe cation per subunit.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS02425 ^@ http://purl.uniprot.org/uniprot/D9PV40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS04240 ^@ http://purl.uniprot.org/uniprot/D9PW62 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/79929:MTBMA_RS01615 ^@ http://purl.uniprot.org/uniprot/Q50744 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mer family.|||Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS07295 ^@ http://purl.uniprot.org/uniprot/D9PXX7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS00665 ^@ http://purl.uniprot.org/uniprot/Q50746 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. http://togogenome.org/gene/79929:MTBMA_RS07510 ^@ http://purl.uniprot.org/uniprot/P80187 ^@ Function|||Induction|||Similarity|||Subunit ^@ Belongs to the MtrH family.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.|||The last gene of the probable mtrEDCBAFGH operon. http://togogenome.org/gene/79929:MTBMA_RS05215 ^@ http://purl.uniprot.org/uniprot/D9PWR4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS05530 ^@ http://purl.uniprot.org/uniprot/D9PWY0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/79929:MTBMA_RS08335 ^@ http://purl.uniprot.org/uniprot/O33174 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS00260 ^@ http://purl.uniprot.org/uniprot/D9PYW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS01700 ^@ http://purl.uniprot.org/uniprot/D9PUP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS04410 ^@ http://purl.uniprot.org/uniprot/D9PW98 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/79929:MTBMA_RS07870 ^@ http://purl.uniprot.org/uniprot/D9PY94 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/79929:MTBMA_RS05935 ^@ http://purl.uniprot.org/uniprot/D9PX59 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/79929:MTBMA_RS00745 ^@ http://purl.uniprot.org/uniprot/D9PU63 ^@ Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family. http://togogenome.org/gene/79929:MTBMA_RS08635 ^@ http://purl.uniprot.org/uniprot/Q50756 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Binds 4 [4Fe-4S] clusters per subunit.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase. http://togogenome.org/gene/79929:MTBMA_RS04125 ^@ http://purl.uniprot.org/uniprot/D9PW36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/79929:MTBMA_RS06075 ^@ http://purl.uniprot.org/uniprot/D9PX86 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/79929:MTBMA_RS01665 ^@ http://purl.uniprot.org/uniprot/D9PUP1 ^@ Function|||Similarity ^@ Belongs to the trehalose phosphatase family.|||Removes the phosphate from trehalose 6-phosphate to produce free trehalose. http://togogenome.org/gene/79929:MTBMA_RS04815 ^@ http://purl.uniprot.org/uniprot/D9PWI0 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/79929:MTBMA_RS02505 ^@ http://purl.uniprot.org/uniprot/D9PV56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/79929:MTBMA_RS08600 ^@ http://purl.uniprot.org/uniprot/P26500 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/79929:MTBMA_RS05050 ^@ http://purl.uniprot.org/uniprot/D9PWM7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the creatininase superfamily. FAPy deformylase family.|||Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).|||Homodimer.|||Requires an additional second metal ion that could be Fe(2+) or Zn(2+).|||Requires one Fe(2+) ion for activity. http://togogenome.org/gene/79929:MTBMA_RS00400 ^@ http://purl.uniprot.org/uniprot/D9PTZ3 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/79929:MTBMA_RS03255 ^@ http://purl.uniprot.org/uniprot/D9PVK8 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/79929:MTBMA_RS02735 ^@ http://purl.uniprot.org/uniprot/D9PVA1 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/79929:MTBMA_RS00715 ^@ http://purl.uniprot.org/uniprot/Q50785 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/79929:MTBMA_RS06545 ^@ http://purl.uniprot.org/uniprot/D9PXI0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/79929:MTBMA_RS04975 ^@ http://purl.uniprot.org/uniprot/D9PWL3 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/79929:MTBMA_RS01285 ^@ http://purl.uniprot.org/uniprot/D9PUH2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS03200 ^@ http://purl.uniprot.org/uniprot/D9PVJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS00965 ^@ http://purl.uniprot.org/uniprot/D9PUA7 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/79929:MTBMA_RS07060 ^@ http://purl.uniprot.org/uniprot/D9PXT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS06595 ^@ http://purl.uniprot.org/uniprot/D9PXJ0 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/79929:MTBMA_RS06975 ^@ http://purl.uniprot.org/uniprot/D9PXR8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS00270 ^@ http://purl.uniprot.org/uniprot/D9PYW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ModE family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS06750 ^@ http://purl.uniprot.org/uniprot/D9PXM1 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/79929:MTBMA_RS00140 ^@ http://purl.uniprot.org/uniprot/D9PYU3 ^@ Similarity ^@ Belongs to the UPF0285 family. http://togogenome.org/gene/79929:MTBMA_RS06840 ^@ http://purl.uniprot.org/uniprot/D9PXN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS01550 ^@ http://purl.uniprot.org/uniprot/P80900 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/79929:MTBMA_RS05230 ^@ http://purl.uniprot.org/uniprot/D9PWR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/79929:MTBMA_RS07470 ^@ http://purl.uniprot.org/uniprot/D9PY13 ^@ Similarity ^@ Belongs to the UPF0254 family. http://togogenome.org/gene/79929:MTBMA_RS04245 ^@ http://purl.uniprot.org/uniprot/D9PW63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS03765 ^@ http://purl.uniprot.org/uniprot/D9PVW3 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/79929:MTBMA_RS02135 ^@ http://purl.uniprot.org/uniprot/D9PUY7 ^@ Caution|||Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/79929:MTBMA_RS05805 ^@ http://purl.uniprot.org/uniprot/D9PX32 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/79929:MTBMA_RS01350 ^@ http://purl.uniprot.org/uniprot/D9PUI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/79929:MTBMA_RS01450 ^@ http://purl.uniprot.org/uniprot/D9PUK5 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/79929:MTBMA_RS08280 ^@ http://purl.uniprot.org/uniprot/D9PYG6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/79929:MTBMA_RS07055 ^@ http://purl.uniprot.org/uniprot/D9PXS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/79929:MTBMA_RS07965 ^@ http://purl.uniprot.org/uniprot/D9PYB2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS03470 ^@ http://purl.uniprot.org/uniprot/D9PVQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/79929:MTBMA_RS03345 ^@ http://purl.uniprot.org/uniprot/D9PVM7 ^@ Similarity ^@ Belongs to the MtxX family. http://togogenome.org/gene/79929:MTBMA_RS02030 ^@ http://purl.uniprot.org/uniprot/D9PUW4 ^@ Similarity ^@ Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/79929:MTBMA_RS04645 ^@ http://purl.uniprot.org/uniprot/D9PWE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS02085 ^@ http://purl.uniprot.org/uniprot/P80910 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/79929:MTBMA_RS00915 ^@ http://purl.uniprot.org/uniprot/D9PU97 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/79929:MTBMA_RS06740 ^@ http://purl.uniprot.org/uniprot/D9PXL9 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/79929:MTBMA_RS07420 ^@ http://purl.uniprot.org/uniprot/D9PY02 ^@ Similarity ^@ Belongs to the MvhD/VhuD family. http://togogenome.org/gene/79929:MTBMA_RS08880 ^@ http://purl.uniprot.org/uniprot/D9PWC8 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/79929:MTBMA_RS07165 ^@ http://purl.uniprot.org/uniprot/D9PXV0 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/79929:MTBMA_RS05240 ^@ http://purl.uniprot.org/uniprot/D9PWR9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/79929:MTBMA_RS02520 ^@ http://purl.uniprot.org/uniprot/D9PV59 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/79929:MTBMA_RS02770 ^@ http://purl.uniprot.org/uniprot/D9PVA8 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/79929:MTBMA_RS00820 ^@ http://purl.uniprot.org/uniprot/D9PU77 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/79929:MTBMA_RS06915 ^@ http://purl.uniprot.org/uniprot/P80904 ^@ Subunit ^@ Heterotetramer of the KorA, KorB, KorC and KorD subunits. http://togogenome.org/gene/79929:MTBMA_RS00725 ^@ http://purl.uniprot.org/uniprot/Q50787 ^@ Function|||Similarity ^@ Belongs to the P(II) protein family.|||Could be involved in the regulation of nitrogen fixation. http://togogenome.org/gene/79929:MTBMA_RS03060 ^@ http://purl.uniprot.org/uniprot/D9PVG9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS02105 ^@ http://purl.uniprot.org/uniprot/D9PUY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS01160 ^@ http://purl.uniprot.org/uniprot/P26939 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/79929:MTBMA_RS08500 ^@ http://purl.uniprot.org/uniprot/Q50497 ^@ Cofactor|||Domain|||Function|||Induction|||Similarity|||Subunit ^@ Binds 1 FMN per subunit.|||Binds 2 iron ions per subunit.|||By iron limitation.|||Catalyzes the oxidation of F420H(2) with O(2) (PubMed:15340796, PubMed:16218963). May be involved in O(2) detoxification, reducing the intracellular O(2) concentration to a level allowing growth at the expense of methane formation (PubMed:15340796).|||Contains an N-terminal beta-lactamase-like domain harboring a di-iron center, and a C-terminal flavodoxin-like domain containing FMN. Two monomers assemble via a head-to-tail arrangement, such that the beta-lactamase and the flavodoxin domains face each other, thereby forming two separated and presumably independent active sites.|||Homodimer (PubMed:7649162). Homotetramer (PubMed:7730275, PubMed:17480207). The tetramer is composed of two functional dimers (PubMed:17480207).|||In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/79929:MTBMA_RS07380 ^@ http://purl.uniprot.org/uniprot/P58816 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS05840 ^@ http://purl.uniprot.org/uniprot/D9PX39 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/79929:MTBMA_RS01005 ^@ http://purl.uniprot.org/uniprot/D9PUB5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/79929:MTBMA_RS01015 ^@ http://purl.uniprot.org/uniprot/D9PUB7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS04175 ^@ http://purl.uniprot.org/uniprot/D9PW48 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/79929:MTBMA_RS08030 ^@ http://purl.uniprot.org/uniprot/D9PYC5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS00440 ^@ http://purl.uniprot.org/uniprot/D9PU02 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent. http://togogenome.org/gene/79929:MTBMA_RS02580 ^@ http://purl.uniprot.org/uniprot/D9PV70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/79929:MTBMA_RS04850 ^@ http://purl.uniprot.org/uniprot/D9PWI7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homooctamer. http://togogenome.org/gene/79929:MTBMA_RS02980 ^@ http://purl.uniprot.org/uniprot/D9PVF3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/79929:MTBMA_RS05105 ^@ http://purl.uniprot.org/uniprot/D9PWN9 ^@ Function|||Similarity ^@ Belongs to the P(II) protein family.|||Could be involved in the regulation of nitrogen fixation. http://togogenome.org/gene/79929:MTBMA_RS02460 ^@ http://purl.uniprot.org/uniprot/D9PV47 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/79929:MTBMA_RS04730 ^@ http://purl.uniprot.org/uniprot/D9PWG3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/79929:MTBMA_RS07275 ^@ http://purl.uniprot.org/uniprot/D9PXX3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/79929:MTBMA_RS06970 ^@ http://purl.uniprot.org/uniprot/D9PXR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/79929:MTBMA_RS03540 ^@ http://purl.uniprot.org/uniprot/D9PVR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS04090 ^@ http://purl.uniprot.org/uniprot/D9PW29 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/79929:MTBMA_RS05775 ^@ http://purl.uniprot.org/uniprot/D9PX28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS06690 ^@ http://purl.uniprot.org/uniprot/D9PXK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS00705 ^@ http://purl.uniprot.org/uniprot/Q59579 ^@ Function|||Induction|||Similarity|||Subunit ^@ Belongs to the FwdC/FmdC family.|||By growth on tungsten or molybdenum under anaerobic conditions.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile.|||This enzyme is composed of seven subunits FwdA (65 kDa), FwdB (53 kDa), FwdC (31 kDa), FwdD (15 kDa), FwdE, FwdF and FwdG. http://togogenome.org/gene/79929:MTBMA_RS08040 ^@ http://purl.uniprot.org/uniprot/D9PYC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS01980 ^@ http://purl.uniprot.org/uniprot/D9PUV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS08385 ^@ http://purl.uniprot.org/uniprot/D9PYI7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS06375 ^@ http://purl.uniprot.org/uniprot/D9PXE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/79929:MTBMA_RS05205 ^@ http://purl.uniprot.org/uniprot/D9PWR2 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/79929:MTBMA_RS00395 ^@ http://purl.uniprot.org/uniprot/D9PTZ2 ^@ Caution|||Function|||Similarity ^@ Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS02565 ^@ http://purl.uniprot.org/uniprot/D9PV68 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/79929:MTBMA_RS07785 ^@ http://purl.uniprot.org/uniprot/D9PY77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07410 ^@ http://purl.uniprot.org/uniprot/P60238 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MvhD/VhuD family.|||Binds 1 [2Fe-2S] cluster.|||Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase.|||The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr). http://togogenome.org/gene/79929:MTBMA_RS08005 ^@ http://purl.uniprot.org/uniprot/D9PYC0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07865 ^@ http://purl.uniprot.org/uniprot/D9PY93 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS01240 ^@ http://purl.uniprot.org/uniprot/D9PUG3 ^@ Similarity ^@ Belongs to the phosphosulfolactate synthase family. http://togogenome.org/gene/79929:MTBMA_RS07340 ^@ http://purl.uniprot.org/uniprot/D9PXY6 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.|||Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS06860 ^@ http://purl.uniprot.org/uniprot/D9PXP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS00850 ^@ http://purl.uniprot.org/uniprot/D9PU83 ^@ Similarity ^@ Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/79929:MTBMA_RS06835 ^@ http://purl.uniprot.org/uniprot/D9PXN8 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/79929:MTBMA_RS02180 ^@ http://purl.uniprot.org/uniprot/D9PUZ6 ^@ Similarity ^@ Belongs to the radical SAM superfamily. NifB family. http://togogenome.org/gene/79929:MTBMA_RS06905 ^@ http://purl.uniprot.org/uniprot/D9PXQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS05850 ^@ http://purl.uniprot.org/uniprot/D9PX41 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/79929:MTBMA_RS05665 ^@ http://purl.uniprot.org/uniprot/D9PX06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS00735 ^@ http://purl.uniprot.org/uniprot/P95296 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Binds 1 [8Fe-7S] cluster per heterodimer.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/79929:MTBMA_RS03655 ^@ http://purl.uniprot.org/uniprot/D9PVU1 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/79929:MTBMA_RS01095 ^@ http://purl.uniprot.org/uniprot/D9PUD4 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/79929:MTBMA_RS03395 ^@ http://purl.uniprot.org/uniprot/D9PVN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/79929:MTBMA_RS02625 ^@ http://purl.uniprot.org/uniprot/D9PV78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS03510 ^@ http://purl.uniprot.org/uniprot/D9PVR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/79929:MTBMA_RS01510 ^@ http://purl.uniprot.org/uniprot/D9PUL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/79929:MTBMA_RS03210 ^@ http://purl.uniprot.org/uniprot/D9PVJ9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/79929:MTBMA_RS02985 ^@ http://purl.uniprot.org/uniprot/D9PVF4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/79929:MTBMA_RS01930 ^@ http://purl.uniprot.org/uniprot/D9PUU4 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/79929:MTBMA_RS02570 ^@ http://purl.uniprot.org/uniprot/D9PV69 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/79929:MTBMA_RS00635 ^@ http://purl.uniprot.org/uniprot/D9PU41 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/79929:MTBMA_RS00885 ^@ http://purl.uniprot.org/uniprot/D9PU90 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/79929:MTBMA_RS07505 ^@ http://purl.uniprot.org/uniprot/D9PY20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS02515 ^@ http://purl.uniprot.org/uniprot/D9PV58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS03445 ^@ http://purl.uniprot.org/uniprot/D9PVP7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/79929:MTBMA_RS00160 ^@ http://purl.uniprot.org/uniprot/D9PYU7 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/79929:MTBMA_RS05195 ^@ http://purl.uniprot.org/uniprot/D9PWR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/79929:MTBMA_RS05690 ^@ http://purl.uniprot.org/uniprot/D9PX12 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/79929:MTBMA_RS08285 ^@ http://purl.uniprot.org/uniprot/D9PYG7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS05895 ^@ http://purl.uniprot.org/uniprot/D9PX50 ^@ Similarity ^@ Belongs to the UPF0305 family. http://togogenome.org/gene/79929:MTBMA_RS01265 ^@ http://purl.uniprot.org/uniprot/D9PUG8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/79929:MTBMA_RS02725 ^@ http://purl.uniprot.org/uniprot/Q9C4Z5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS06960 ^@ http://purl.uniprot.org/uniprot/D9PXR5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS02660 ^@ http://purl.uniprot.org/uniprot/D9PV85 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS01110 ^@ http://purl.uniprot.org/uniprot/D9PUD7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/79929:MTBMA_RS04855 ^@ http://purl.uniprot.org/uniprot/D9PWI8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS03450 ^@ http://purl.uniprot.org/uniprot/D9PVP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS05330 ^@ http://purl.uniprot.org/uniprot/P80908 ^@ Subunit ^@ Heterotrimer of the VorA, VorB and VorC subunits. http://togogenome.org/gene/79929:MTBMA_RS03135 ^@ http://purl.uniprot.org/uniprot/D9PVI4 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/79929:MTBMA_RS03500 ^@ http://purl.uniprot.org/uniprot/D9PVQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/79929:MTBMA_RS00585 ^@ http://purl.uniprot.org/uniprot/D9PU31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS06930 ^@ http://purl.uniprot.org/uniprot/D9PXQ7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/79929:MTBMA_RS04515 ^@ http://purl.uniprot.org/uniprot/D9PWB9 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/79929:MTBMA_RS02435 ^@ http://purl.uniprot.org/uniprot/D9PV42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/79929:MTBMA_RS07550 ^@ http://purl.uniprot.org/uniprot/P11558 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:3350018, PubMed:9367957). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (PubMed:9030728).|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018, PubMed:27140643). Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).|||Cytoplasm|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.|||Methyl-coenzyme M reductase activity is inhibited by 3-nitrooxypropanol (3-NOP) in vitro and in vivo, by oxidation of its active site Ni(I), which stops both growth and methanogenesis (PubMed:27140643). Is also inhibited by the reaction product CoM-S-S-CoB (PubMed:3350018).|||The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.|||The alpha subunit contains six modified amino acids near the active site region (PubMed:27467699). Is methylated on His-257, Arg-271, Gln-400 and Cys-452, probably by the action of specific S-adenosylmethionine-dependent methyltransferases. Also contains a thioglycine at position 445, forming a thiopeptide bond (PubMed:10660523, PubMed:9367957, PubMed:11491299, PubMed:20707311, PubMed:21438550, PubMed:27467699). Contains a didehydroaspartate residue at position 450 (PubMed:27467699). The methylation on C5 of Arg-271 is a post-translational methylation not essential in vivo, but which plays a role for the stability and structural integrity of MCR (By similarity).|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS02935 ^@ http://purl.uniprot.org/uniprot/D9PVE4 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS02455 ^@ http://purl.uniprot.org/uniprot/D9PV46 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/79929:MTBMA_RS00005 ^@ http://purl.uniprot.org/uniprot/D9PYR8 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/79929:MTBMA_RS00425 ^@ http://purl.uniprot.org/uniprot/D9PTZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.|||Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).|||Homotetramer. Interacts with SepCysS. http://togogenome.org/gene/79929:MTBMA_RS02035 ^@ http://purl.uniprot.org/uniprot/D9PUW5 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/79929:MTBMA_RS02090 ^@ http://purl.uniprot.org/uniprot/P80911 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/79929:MTBMA_RS02185 ^@ http://purl.uniprot.org/uniprot/D9PUZ7 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/79929:MTBMA_RS03030 ^@ http://purl.uniprot.org/uniprot/D9PVG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/79929:MTBMA_RS00955 ^@ http://purl.uniprot.org/uniprot/D9PUA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/79929:MTBMA_RS07680 ^@ http://purl.uniprot.org/uniprot/D9PY55 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS03315 ^@ http://purl.uniprot.org/uniprot/D9PVM1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/79929:MTBMA_RS03055 ^@ http://purl.uniprot.org/uniprot/D9PVG8 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/79929:MTBMA_RS04705 ^@ http://purl.uniprot.org/uniprot/D9PWF8 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/79929:MTBMA_RS01310 ^@ http://purl.uniprot.org/uniprot/D9PUH7 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/79929:MTBMA_RS06845 ^@ http://purl.uniprot.org/uniprot/D9PXP0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CofE family.|||Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.|||Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.|||Homodimer.|||Monovalent cation. The ion could be potassium. http://togogenome.org/gene/79929:MTBMA_RS06265 ^@ http://purl.uniprot.org/uniprot/D9PXC5 ^@ Similarity ^@ Belongs to the UPF0292 family. http://togogenome.org/gene/79929:MTBMA_RS08135 ^@ http://purl.uniprot.org/uniprot/D9PYE0 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/79929:MTBMA_RS01250 ^@ http://purl.uniprot.org/uniprot/D9PUG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/79929:MTBMA_RS03495 ^@ http://purl.uniprot.org/uniprot/D9PVQ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/79929:MTBMA_RS01420 ^@ http://purl.uniprot.org/uniprot/D9PUJ9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CdhC family.|||Binds 1 [Ni-Fe-S] cluster.|||Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). http://togogenome.org/gene/79929:MTBMA_RS03150 ^@ http://purl.uniprot.org/uniprot/D9PVI7 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD(+) and NADP(+) with similar specific activity. http://togogenome.org/gene/79929:MTBMA_RS01585 ^@ http://purl.uniprot.org/uniprot/D9PUM9 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/79929:MTBMA_RS07520 ^@ http://purl.uniprot.org/uniprot/Q50773 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrF family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||Part of the probable mtrEDCBAFGH operon.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS00865 ^@ http://purl.uniprot.org/uniprot/D9PU86 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/79929:MTBMA_RS08820 ^@ http://purl.uniprot.org/uniprot/D9PX49 ^@ Similarity ^@ Belongs to the UPF0305 family. http://togogenome.org/gene/79929:MTBMA_RS01800 ^@ http://purl.uniprot.org/uniprot/D9PUR7 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/79929:MTBMA_RS03230 ^@ http://purl.uniprot.org/uniprot/D9PVK3 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS03415 ^@ http://purl.uniprot.org/uniprot/D9PVP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS06210 ^@ http://purl.uniprot.org/uniprot/D9PXB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/79929:MTBMA_RS04550 ^@ http://purl.uniprot.org/uniprot/D9PWC6 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/79929:MTBMA_RS01545 ^@ http://purl.uniprot.org/uniprot/P80901 ^@ Cofactor|||Subunit ^@ Binds 1 [4Fe-4S] cluster per subunit.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/79929:MTBMA_RS06490 ^@ http://purl.uniprot.org/uniprot/D9PXG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/79929:MTBMA_RS07710 ^@ http://purl.uniprot.org/uniprot/D9PY61 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/79929:MTBMA_RS00645 ^@ http://purl.uniprot.org/uniprot/D9PU43 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/79929:MTBMA_RS05980 ^@ http://purl.uniprot.org/uniprot/D9PX67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Heterotetramer of 2 HacA and 2 HacB proteins.|||Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B. http://togogenome.org/gene/79929:MTBMA_RS02470 ^@ http://purl.uniprot.org/uniprot/D9PV49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS08330 ^@ http://purl.uniprot.org/uniprot/D9PYH6 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/79929:MTBMA_RS00110 ^@ http://purl.uniprot.org/uniprot/D9PYT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/79929:MTBMA_RS05245 ^@ http://purl.uniprot.org/uniprot/D9PWS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/79929:MTBMA_RS04675 ^@ http://purl.uniprot.org/uniprot/D9PWF2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS01270 ^@ http://purl.uniprot.org/uniprot/D9PUG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/79929:MTBMA_RS02560 ^@ http://purl.uniprot.org/uniprot/D9PV67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS08615 ^@ http://purl.uniprot.org/uniprot/D9PYN4 ^@ Similarity ^@ Belongs to the UPF0127 family. http://togogenome.org/gene/79929:MTBMA_RS07610 ^@ http://purl.uniprot.org/uniprot/D9PY40 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/79929:MTBMA_RS07400 ^@ http://purl.uniprot.org/uniprot/P60227 ^@ Function|||Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.|||Part of a complex that provides reducing equivalents for heterodisulfide reductase.|||The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr). http://togogenome.org/gene/79929:MTBMA_RS05440 ^@ http://purl.uniprot.org/uniprot/D9PWW2 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS00655 ^@ http://purl.uniprot.org/uniprot/D9PU45 ^@ Similarity ^@ Belongs to the complex I 24 kDa subunit family. http://togogenome.org/gene/79929:MTBMA_RS07525 ^@ http://purl.uniprot.org/uniprot/P80184 ^@ Cofactor|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||Part of the probable mtrEDCBAFGH operon.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS05710 ^@ http://purl.uniprot.org/uniprot/P55299 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5-methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L-homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate.|||Is activated by phosphates. http://togogenome.org/gene/79929:MTBMA_RS06925 ^@ http://purl.uniprot.org/uniprot/P80906 ^@ Subunit ^@ Heterotetramer of the KorA, KorB, KorC and KorD subunits. http://togogenome.org/gene/79929:MTBMA_RS07395 ^@ http://purl.uniprot.org/uniprot/P60232 ^@ Cofactor ^@ Binds 12 [4Fe-4S] clusters. http://togogenome.org/gene/79929:MTBMA_RS07325 ^@ http://purl.uniprot.org/uniprot/D9PXY3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/79929:MTBMA_RS02315 ^@ http://purl.uniprot.org/uniprot/D9PV19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS06810 ^@ http://purl.uniprot.org/uniprot/P42809 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA (By similarity).|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization (By similarity). http://togogenome.org/gene/79929:MTBMA_RS08690 ^@ http://purl.uniprot.org/uniprot/D9PYP9 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/79929:MTBMA_RS04215 ^@ http://purl.uniprot.org/uniprot/D9PW57 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/79929:MTBMA_RS07050 ^@ http://purl.uniprot.org/uniprot/D9PXS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS00525 ^@ http://purl.uniprot.org/uniprot/D9PU19 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/79929:MTBMA_RS02835 ^@ http://purl.uniprot.org/uniprot/D9PVC4 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/79929:MTBMA_RS02930 ^@ http://purl.uniprot.org/uniprot/D9PVE3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.|||Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. http://togogenome.org/gene/79929:MTBMA_RS06380 ^@ http://purl.uniprot.org/uniprot/D9PXE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS03320 ^@ http://purl.uniprot.org/uniprot/D9PVM2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS03490 ^@ http://purl.uniprot.org/uniprot/D9PVQ6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/79929:MTBMA_RS07740 ^@ http://purl.uniprot.org/uniprot/D9PY67 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/79929:MTBMA_RS02905 ^@ http://purl.uniprot.org/uniprot/D9PVD8 ^@ Function|||Similarity ^@ Belongs to the MfnB family.|||Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/79929:MTBMA_RS03240 ^@ http://purl.uniprot.org/uniprot/D9PVK5 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/79929:MTBMA_RS06200 ^@ http://purl.uniprot.org/uniprot/D9PXB1 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/79929:MTBMA_RS01275 ^@ http://purl.uniprot.org/uniprot/D9PUH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/79929:MTBMA_RS07195 ^@ http://purl.uniprot.org/uniprot/D9PXV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS05885 ^@ http://purl.uniprot.org/uniprot/D9PX48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/79929:MTBMA_RS08065 ^@ http://purl.uniprot.org/uniprot/D9PYD2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS07935 ^@ http://purl.uniprot.org/uniprot/D9PYA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS08665 ^@ http://purl.uniprot.org/uniprot/D9PYP4 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/79929:MTBMA_RS01435 ^@ http://purl.uniprot.org/uniprot/D9PUK2 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 [4Fe-4S] cluster.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). http://togogenome.org/gene/79929:MTBMA_RS02555 ^@ http://purl.uniprot.org/uniprot/D9PV66 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/79929:MTBMA_RS02950 ^@ http://purl.uniprot.org/uniprot/D9PVE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS08070 ^@ http://purl.uniprot.org/uniprot/D9PYD3 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/79929:MTBMA_RS08655 ^@ http://purl.uniprot.org/uniprot/D9PYP2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/79929:MTBMA_RS01255 ^@ http://purl.uniprot.org/uniprot/D9PUG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS06570 ^@ http://purl.uniprot.org/uniprot/D9PXI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS08710 ^@ http://purl.uniprot.org/uniprot/D9PYQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.|||Homotetramer; dimer of dimers. http://togogenome.org/gene/79929:MTBMA_RS01990 ^@ http://purl.uniprot.org/uniprot/D9PUV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/79929:MTBMA_RS05860 ^@ http://purl.uniprot.org/uniprot/D9PX43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS07460 ^@ http://purl.uniprot.org/uniprot/D9PY11 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/79929:MTBMA_RS08585 ^@ http://purl.uniprot.org/uniprot/D9PYM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS02865 ^@ http://purl.uniprot.org/uniprot/Q50801 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/79929:MTBMA_RS00510 ^@ http://purl.uniprot.org/uniprot/D9PU16 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/79929:MTBMA_RS00170 ^@ http://purl.uniprot.org/uniprot/D9PYU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS08355 ^@ http://purl.uniprot.org/uniprot/D9PYI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/79929:MTBMA_RS08305 ^@ http://purl.uniprot.org/uniprot/D9PYH1 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/79929:MTBMA_RS05515 ^@ http://purl.uniprot.org/uniprot/D9PWX7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the small carbamoyl-phosphate synthase family.|||Binds 2 magnesium or manganese ions per subunit.|||Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate. http://togogenome.org/gene/79929:MTBMA_RS05030 ^@ http://purl.uniprot.org/uniprot/D9PWM2 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/79929:MTBMA_RS02355 ^@ http://purl.uniprot.org/uniprot/D9PV26 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/79929:MTBMA_RS00800 ^@ http://purl.uniprot.org/uniprot/D9PU73 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/79929:MTBMA_RS08270 ^@ http://purl.uniprot.org/uniprot/D9PYG4 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/79929:MTBMA_RS00275 ^@ http://purl.uniprot.org/uniprot/D9PYX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS01855 ^@ http://purl.uniprot.org/uniprot/D9PUS9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS02195 ^@ http://purl.uniprot.org/uniprot/D9PUZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/79929:MTBMA_RS01280 ^@ http://purl.uniprot.org/uniprot/D9PUH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/79929:MTBMA_RS03895 ^@ http://purl.uniprot.org/uniprot/D9PVZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS01205 ^@ http://purl.uniprot.org/uniprot/D9PUF5 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/79929:MTBMA_RS01710 ^@ http://purl.uniprot.org/uniprot/D9PUQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/79929:MTBMA_RS00295 ^@ http://purl.uniprot.org/uniprot/D9PTX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/79929:MTBMA_RS04235 ^@ http://purl.uniprot.org/uniprot/D9PW61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS07270 ^@ http://purl.uniprot.org/uniprot/D9PXX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS08490 ^@ http://purl.uniprot.org/uniprot/D9PYK8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/79929:MTBMA_RS04620 ^@ http://purl.uniprot.org/uniprot/D9PWE0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/79929:MTBMA_RS08235 ^@ http://purl.uniprot.org/uniprot/D9PYF9 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/79929:MTBMA_RS01140 ^@ http://purl.uniprot.org/uniprot/D9PUE3 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/79929:MTBMA_RS04360 ^@ http://purl.uniprot.org/uniprot/D9PW88 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/79929:MTBMA_RS05480 ^@ http://purl.uniprot.org/uniprot/D9PWX0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/79929:MTBMA_RS05925 ^@ http://purl.uniprot.org/uniprot/D9PX57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS08510 ^@ http://purl.uniprot.org/uniprot/D9PYL2 ^@ Function ^@ Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/79929:MTBMA_RS03220 ^@ http://purl.uniprot.org/uniprot/D9PVK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/79929:MTBMA_RS02500 ^@ http://purl.uniprot.org/uniprot/D9PV55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS07320 ^@ http://purl.uniprot.org/uniprot/D9PXY2 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/79929:MTBMA_RS06165 ^@ http://purl.uniprot.org/uniprot/D9PXA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/79929:MTBMA_RS06110 ^@ http://purl.uniprot.org/uniprot/D9PX93 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/79929:MTBMA_RS01320 ^@ http://purl.uniprot.org/uniprot/D9PUH9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane http://togogenome.org/gene/79929:MTBMA_RS06650 ^@ http://purl.uniprot.org/uniprot/D9PXK1 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/79929:MTBMA_RS07230 ^@ http://purl.uniprot.org/uniprot/D9PXW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/79929:MTBMA_RS00875 ^@ http://purl.uniprot.org/uniprot/D9PU88 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/79929:MTBMA_RS00990 ^@ http://purl.uniprot.org/uniprot/D9PUB2 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/79929:MTBMA_RS08365 ^@ http://purl.uniprot.org/uniprot/D9PYI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/79929:MTBMA_RS04875 ^@ http://purl.uniprot.org/uniprot/D9PWJ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/79929:MTBMA_RS02545 ^@ http://purl.uniprot.org/uniprot/D9PV64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS08675 ^@ http://purl.uniprot.org/uniprot/D9PYP6 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/79929:MTBMA_RS01300 ^@ http://purl.uniprot.org/uniprot/D9PUH5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/79929:MTBMA_RS08275 ^@ http://purl.uniprot.org/uniprot/D9PYG5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/79929:MTBMA_RS00080 ^@ http://purl.uniprot.org/uniprot/D9PYT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS04270 ^@ http://purl.uniprot.org/uniprot/D9PW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/79929:MTBMA_RS06045 ^@ http://purl.uniprot.org/uniprot/D9PX80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS05445 ^@ http://purl.uniprot.org/uniprot/D9PWW3 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/79929:MTBMA_RS04000 ^@ http://purl.uniprot.org/uniprot/D9PW10 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/79929:MTBMA_RS07015 ^@ http://purl.uniprot.org/uniprot/D9PXS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/79929:MTBMA_RS07375 ^@ http://purl.uniprot.org/uniprot/P58815 ^@ Cofactor|||Developmental Stage|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:27467699). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (By similarity).|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.|||The alpha subunit contains six modified amino acids near the active site region. Is methylated on His-260, Arg-274, Gln-402 and Cys-454, probably by the action of specific S-adenosylmethionine-dependent methyltransferases. Also contains a thioglycine at position 447, forming a thiopeptide bond. Contains a didehydroaspartate residue at position 452 (PubMed:27467699). The methylation on C5 of Arg-274 is a post-translational methylation not essential in vivo, but which plays a role for the stability and structural integrity of MCR (By similarity).|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS09020 ^@ http://purl.uniprot.org/uniprot/P80183 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrD family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||Part of the probable mtrEDCBAFGH operon.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS05760 ^@ http://purl.uniprot.org/uniprot/D9PX25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07725 ^@ http://purl.uniprot.org/uniprot/D9PY64 ^@ Similarity ^@ Belongs to the LDH2/MDH2 oxidoreductase family. http://togogenome.org/gene/79929:MTBMA_RS01965 ^@ http://purl.uniprot.org/uniprot/D9PUV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS00365 ^@ http://purl.uniprot.org/uniprot/D9PTY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/79929:MTBMA_RS03365 ^@ http://purl.uniprot.org/uniprot/D9PVN1 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS06560 ^@ http://purl.uniprot.org/uniprot/D9PXI3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/79929:MTBMA_RS07570 ^@ http://purl.uniprot.org/uniprot/P11560 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:3350018, PubMed:9367957). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (PubMed:9030728).|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018). Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).|||Cytoplasm|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.|||Methyl-coenzyme M reductase activity is inhibited by 3-nitrooxypropanol (3-NOP) in vitro and in vivo, by oxidation of its active site Ni(I), which stops both growth and methanogenesis (PubMed:27140643). Is also inhibited by the reaction product CoM-S-S-CoB (PubMed:3350018).|||The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.|||There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I. http://togogenome.org/gene/79929:MTBMA_RS00840 ^@ http://purl.uniprot.org/uniprot/D9PU81 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/79929:MTBMA_RS03130 ^@ http://purl.uniprot.org/uniprot/D9PVI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS05555 ^@ http://purl.uniprot.org/uniprot/D9PWY5 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/79929:MTBMA_RS00650 ^@ http://purl.uniprot.org/uniprot/D9PU44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/79929:MTBMA_RS00625 ^@ http://purl.uniprot.org/uniprot/D9PU39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/79929:MTBMA_RS07030 ^@ http://purl.uniprot.org/uniprot/D9PXS4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/79929:MTBMA_RS02630 ^@ http://purl.uniprot.org/uniprot/D9PV79 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/79929:MTBMA_RS00465 ^@ http://purl.uniprot.org/uniprot/D9PU07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/79929:MTBMA_RS06230 ^@ http://purl.uniprot.org/uniprot/D9PXB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/79929:MTBMA_RS07535 ^@ http://purl.uniprot.org/uniprot/P80185 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrC family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||Part of the probable mtrEDCBAFGH operon.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/79929:MTBMA_RS03280 ^@ http://purl.uniprot.org/uniprot/D9PVL4 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/79929:MTBMA_RS01650 ^@ http://purl.uniprot.org/uniprot/D9PUN8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/79929:MTBMA_RS08295 ^@ http://purl.uniprot.org/uniprot/D9PYG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/79929:MTBMA_RS05115 ^@ http://purl.uniprot.org/uniprot/D9PWP2 ^@ Function|||Similarity ^@ Belongs to the P(II) protein family.|||Could be involved in the regulation of nitrogen fixation. http://togogenome.org/gene/79929:MTBMA_RS01560 ^@ http://purl.uniprot.org/uniprot/P80902 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/79929:MTBMA_RS04070 ^@ http://purl.uniprot.org/uniprot/D9PW25 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/79929:MTBMA_RS00975 ^@ http://purl.uniprot.org/uniprot/D9PUA9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Belongs to the ribosomal protein L31e family. http://togogenome.org/gene/79929:MTBMA_RS00870 ^@ http://purl.uniprot.org/uniprot/D9PU87 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/79929:MTBMA_RS03175 ^@ http://purl.uniprot.org/uniprot/D9PVJ2 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/79929:MTBMA_RS06635 ^@ http://purl.uniprot.org/uniprot/D9PXJ8 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/79929:MTBMA_RS03410 ^@ http://purl.uniprot.org/uniprot/D9PVP0 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/79929:MTBMA_RS01390 ^@ http://purl.uniprot.org/uniprot/D9PUJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system.|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/79929:MTBMA_RS00970 ^@ http://purl.uniprot.org/uniprot/D9PUA8 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/79929:MTBMA_RS00995 ^@ http://purl.uniprot.org/uniprot/D9PUB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/79929:MTBMA_RS01035 ^@ http://purl.uniprot.org/uniprot/D9PUC1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/79929:MTBMA_RS02585 ^@ http://purl.uniprot.org/uniprot/D9PV71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/79929:MTBMA_RS06475 ^@ http://purl.uniprot.org/uniprot/D9PXG6 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/79929:MTBMA_RS02915 ^@ http://purl.uniprot.org/uniprot/D9PVE0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/79929:MTBMA_RS07800 ^@ http://purl.uniprot.org/uniprot/D9PY80 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/79929:MTBMA_RS09110 ^@ http://purl.uniprot.org/uniprot/D9PVG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/79929:MTBMA_RS08140 ^@ http://purl.uniprot.org/uniprot/D9PYE1 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/79929:MTBMA_RS00065 ^@ http://purl.uniprot.org/uniprot/D9PYT0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/79929:MTBMA_RS00475 ^@ http://purl.uniprot.org/uniprot/D9PU09 ^@ Similarity ^@ Belongs to the HMD family.