http://togogenome.org/gene/768066:HELO_RS17955 ^@ http://purl.uniprot.org/uniprot/E1VBJ0 ^@ PTM ^@ Binds 2 heme c groups covalently per subunit. http://togogenome.org/gene/768066:HELO_RS05095 ^@ http://purl.uniprot.org/uniprot/E1V9J2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/768066:HELO_RS03135 ^@ http://purl.uniprot.org/uniprot/E1V7C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS18960 ^@ http://purl.uniprot.org/uniprot/E1VCG6 ^@ Function|||Similarity ^@ Belongs to the ParB family.|||Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. http://togogenome.org/gene/768066:HELO_RS12985 ^@ http://purl.uniprot.org/uniprot/E1V668 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS09355 ^@ http://purl.uniprot.org/uniprot/E1V399 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Binds 2 Zn(2+) ions per subunit.|||Monomer.|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/768066:HELO_RS11660 ^@ http://purl.uniprot.org/uniprot/E1V4R1 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/768066:HELO_RS11455 ^@ http://purl.uniprot.org/uniprot/E1V4M0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/768066:HELO_RS03405 ^@ http://purl.uniprot.org/uniprot/E1V7W5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/768066:HELO_RS09725 ^@ http://purl.uniprot.org/uniprot/A0A1R4A4C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS14280 ^@ http://purl.uniprot.org/uniprot/A0A1R4A4I5 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/768066:HELO_RS11035 ^@ http://purl.uniprot.org/uniprot/E1V4E0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/768066:HELO_RS06580 ^@ http://purl.uniprot.org/uniprot/E1VB23 ^@ Function|||Similarity ^@ Belongs to the RlpA family.|||Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. http://togogenome.org/gene/768066:HELO_RS12170 ^@ http://purl.uniprot.org/uniprot/E1V5E1 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/768066:HELO_RS12385 ^@ http://purl.uniprot.org/uniprot/E1V5I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS01755 ^@ http://purl.uniprot.org/uniprot/E1V5V8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS14835 ^@ http://purl.uniprot.org/uniprot/E1V8D4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS13770 ^@ http://purl.uniprot.org/uniprot/E1V713 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS13045 ^@ http://purl.uniprot.org/uniprot/E1V680 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/768066:HELO_RS17135 ^@ http://purl.uniprot.org/uniprot/E1VAQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DksA family.|||Cytoplasm|||Interacts directly with the RNA polymerase.|||Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. http://togogenome.org/gene/768066:HELO_RS11885 ^@ http://purl.uniprot.org/uniprot/E1V587 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS05225 ^@ http://purl.uniprot.org/uniprot/E1V9L8 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/768066:HELO_RS11360 ^@ http://purl.uniprot.org/uniprot/E1V4K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LolA family.|||Monomer.|||Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).|||Periplasm http://togogenome.org/gene/768066:HELO_RS13610 ^@ http://purl.uniprot.org/uniprot/E1V6Y2 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/768066:HELO_RS07395 ^@ http://purl.uniprot.org/uniprot/E1VBW3 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/768066:HELO_RS15650 ^@ http://purl.uniprot.org/uniprot/E1V978 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS07110 ^@ http://purl.uniprot.org/uniprot/E1VBC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RfaH family.|||Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.|||Interacts with both the nontemplate DNA and the RNA polymerase (RNAP). http://togogenome.org/gene/768066:HELO_RS13210 ^@ http://purl.uniprot.org/uniprot/E1V6B2 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.|||Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue. http://togogenome.org/gene/768066:HELO_RS10175 ^@ http://purl.uniprot.org/uniprot/E1V3P8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS11170 ^@ http://purl.uniprot.org/uniprot/E1V4G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/768066:HELO_RS01630 ^@ http://purl.uniprot.org/uniprot/E1V5T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/768066:HELO_RS06775 ^@ http://purl.uniprot.org/uniprot/E1VB62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/768066:HELO_RS03810 ^@ http://purl.uniprot.org/uniprot/E1V835 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PAPS reductase family. CysD subfamily.|||Heterodimer composed of CysD, the smaller subunit, and CysN.|||With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD. http://togogenome.org/gene/768066:HELO_RS09610 ^@ http://purl.uniprot.org/uniprot/E1V3F0 ^@ Similarity ^@ Belongs to the glutaredoxin family. Monothiol subfamily. http://togogenome.org/gene/768066:HELO_RS00050 ^@ http://purl.uniprot.org/uniprot/E1V456 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/768066:HELO_RS01620 ^@ http://purl.uniprot.org/uniprot/E1V5T1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/768066:HELO_RS13205 ^@ http://purl.uniprot.org/uniprot/E1V6B1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/768066:HELO_RS16340 ^@ http://purl.uniprot.org/uniprot/E1V9Z2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 7 family.|||Homodimer.|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||Periplasm http://togogenome.org/gene/768066:HELO_RS15125 ^@ http://purl.uniprot.org/uniprot/E1V8I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Cell inner membrane|||Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).|||In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family.|||Membrane http://togogenome.org/gene/768066:HELO_RS09325 ^@ http://purl.uniprot.org/uniprot/E1V393 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/768066:HELO_RS18920 ^@ http://purl.uniprot.org/uniprot/E1VCF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/768066:HELO_RS15275 ^@ http://purl.uniprot.org/uniprot/E1V8L9 ^@ Function|||Similarity ^@ Belongs to the LpxB family.|||Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/768066:HELO_RS06670 ^@ http://purl.uniprot.org/uniprot/E1VB41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/768066:HELO_RS14485 ^@ http://purl.uniprot.org/uniprot/E1V7T2 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/768066:HELO_RS15625 ^@ http://purl.uniprot.org/uniprot/E1V973 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/768066:HELO_RS17175 ^@ http://purl.uniprot.org/uniprot/E1VAR4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/768066:HELO_RS01365 ^@ http://purl.uniprot.org/uniprot/E1V5N1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/768066:HELO_RS05365 ^@ http://purl.uniprot.org/uniprot/E1V9P5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/768066:HELO_RS18430 ^@ http://purl.uniprot.org/uniprot/E1VBS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/768066:HELO_RS13670 ^@ http://purl.uniprot.org/uniprot/E1V6Z4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/768066:HELO_RS00815 ^@ http://purl.uniprot.org/uniprot/E1V4Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS17200 ^@ http://purl.uniprot.org/uniprot/E1VAR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/768066:HELO_RS15065 ^@ http://purl.uniprot.org/uniprot/E1V8H7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/768066:HELO_RS13860 ^@ http://purl.uniprot.org/uniprot/E1V730 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/768066:HELO_RS05030 ^@ http://purl.uniprot.org/uniprot/E1V9I0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MlaE permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD). http://togogenome.org/gene/768066:HELO_RS03320 ^@ http://purl.uniprot.org/uniprot/E1V7G4 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/768066:HELO_RS15135 ^@ http://purl.uniprot.org/uniprot/E1V8J1 ^@ Cofactor|||Induction|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese.|||Up-regulated by salt. http://togogenome.org/gene/768066:HELO_RS05205 ^@ http://purl.uniprot.org/uniprot/E1V9L4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS02830 ^@ http://purl.uniprot.org/uniprot/E1V768 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS09535 ^@ http://purl.uniprot.org/uniprot/E1V3D5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/768066:HELO_RS01310 ^@ http://purl.uniprot.org/uniprot/E1V5M0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/768066:HELO_RS15935 ^@ http://purl.uniprot.org/uniprot/E1V9D3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS11855 ^@ http://purl.uniprot.org/uniprot/E1V581 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase bacterial subunit 4 family.|||Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.|||Heterooctamer of two A chains, two B chains, two C chains and two D chains.|||Membrane http://togogenome.org/gene/768066:HELO_RS00630 ^@ http://purl.uniprot.org/uniprot/E1V4V6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS13375 ^@ http://purl.uniprot.org/uniprot/E1V6T6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/768066:HELO_RS09430 ^@ http://purl.uniprot.org/uniprot/E1V3B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.|||Cytoplasm|||Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. http://togogenome.org/gene/768066:HELO_RS01325 ^@ http://purl.uniprot.org/uniprot/E1V5M3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/768066:HELO_RS15600 ^@ http://purl.uniprot.org/uniprot/E1V968 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/768066:HELO_RS01890 ^@ http://purl.uniprot.org/uniprot/E1V5X9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/768066:HELO_RS18030 ^@ http://purl.uniprot.org/uniprot/E1VBK4 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding protein that negatively regulates activity of the tripartite ATP-independent periplasmic (TRAP) ectoine transport system TeaABC. May regulate uptake according to the ATP status of the cell.|||Belongs to the universal stress protein A family.|||Cotranscribed along with teaABC.|||Cytoplasm|||Deletion results in an enhanced uptake for ectoine by TeaABC.|||Homodimer or homotetramer; in equilibrium. The dimer/tetramer ratio is ATP-dependent. ATP stabilizes dimer-dimer complexes, with one ATP molecule bound to each monomer. http://togogenome.org/gene/768066:HELO_RS01300 ^@ http://purl.uniprot.org/uniprot/E1V5L8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS15635 ^@ http://purl.uniprot.org/uniprot/E1V975 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/768066:HELO_RS01740 ^@ http://purl.uniprot.org/uniprot/E1V5V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/768066:HELO_RS05050 ^@ http://purl.uniprot.org/uniprot/E1V9I4 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/768066:HELO_RS01350 ^@ http://purl.uniprot.org/uniprot/E1V5M8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/768066:HELO_RS06630 ^@ http://purl.uniprot.org/uniprot/E1VB33 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/768066:HELO_RS18945 ^@ http://purl.uniprot.org/uniprot/E1VCG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/768066:HELO_RS00625 ^@ http://purl.uniprot.org/uniprot/E1V4V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/768066:HELO_RS02495 ^@ http://purl.uniprot.org/uniprot/E1V6M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane http://togogenome.org/gene/768066:HELO_RS04045 ^@ http://purl.uniprot.org/uniprot/E1V875 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS13785 ^@ http://purl.uniprot.org/uniprot/E1V716 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS01260 ^@ http://purl.uniprot.org/uniprot/E1V5L0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/768066:HELO_RS17335 ^@ http://purl.uniprot.org/uniprot/E1VAU3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/768066:HELO_RS00170 ^@ http://purl.uniprot.org/uniprot/E1V478 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecB family.|||Cytoplasm|||Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.|||One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. http://togogenome.org/gene/768066:HELO_RS06655 ^@ http://purl.uniprot.org/uniprot/E1VB38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NqrA family.|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/768066:HELO_RS00020 ^@ http://purl.uniprot.org/uniprot/E1V450 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/768066:HELO_RS04920 ^@ http://purl.uniprot.org/uniprot/E1V9F9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/768066:HELO_RS00995 ^@ http://purl.uniprot.org/uniprot/E1V529 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS19000 ^@ http://purl.uniprot.org/uniprot/E1VCH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS13015 ^@ http://purl.uniprot.org/uniprot/E1V674 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.|||This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. http://togogenome.org/gene/768066:HELO_RS14610 ^@ http://purl.uniprot.org/uniprot/E1V7V7 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm|||Deletion mutant is impaired in growth on ectoine as a sole carbon source.|||DoeD and EctB both catalyze the same transamination reaction between L-aspartate 4-semialdehyde and L-2,4-diaminobutanoate coupled to the 2-oxoglutarate/L-glutamate pair. This reversible reaction is part of both, ectoine biosynthesis and ectoine degradation.|||Involved in the degradation of ectoine, which allows H.elongata to utilize ectoine as both a carbon and a nitrogen source for growth. Probably catalyzes the conversion of L-2,4-diaminobutyrate (DABA) to L-aspartate beta-semialdehyde (ASA) by transamination with 2-oxoglutarate. http://togogenome.org/gene/768066:HELO_RS11520 ^@ http://purl.uniprot.org/uniprot/E1V4N3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS01285 ^@ http://purl.uniprot.org/uniprot/E1V5L5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/768066:HELO_RS05505 ^@ http://purl.uniprot.org/uniprot/E1V9R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS01295 ^@ http://purl.uniprot.org/uniprot/E1V5L7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/768066:HELO_RS04005 ^@ http://purl.uniprot.org/uniprot/E1V867 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfur carrier protein TusA family.|||Cytoplasm|||Sulfur carrier protein which probably makes part of a sulfur-relay system. http://togogenome.org/gene/768066:HELO_RS03195 ^@ http://purl.uniprot.org/uniprot/E1V7E0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS17125 ^@ http://purl.uniprot.org/uniprot/E1VAQ4 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/768066:HELO_RS09465 ^@ http://purl.uniprot.org/uniprot/E1V3C1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/768066:HELO_RS13540 ^@ http://purl.uniprot.org/uniprot/E1V6W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 51 family.|||Cell inner membrane|||Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. http://togogenome.org/gene/768066:HELO_RS03925 ^@ http://purl.uniprot.org/uniprot/E1V856 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/768066:HELO_RS01870 ^@ http://purl.uniprot.org/uniprot/E1V5X5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/768066:HELO_RS00425 ^@ http://purl.uniprot.org/uniprot/E1V4C8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/768066:HELO_RS08810 ^@ http://purl.uniprot.org/uniprot/E1V316 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS17375 ^@ http://purl.uniprot.org/uniprot/E1VAV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/768066:HELO_RS10355 ^@ http://purl.uniprot.org/uniprot/E1V3T0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/768066:HELO_RS02160 ^@ http://purl.uniprot.org/uniprot/E1V6G3 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/768066:HELO_RS06680 ^@ http://purl.uniprot.org/uniprot/E1VB43 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrF family.|||Binds 1 [2Fe-2S] cluster.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. http://togogenome.org/gene/768066:HELO_RS11655 ^@ http://purl.uniprot.org/uniprot/E1V4R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS05595 ^@ http://purl.uniprot.org/uniprot/E1V9T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS14925 ^@ http://purl.uniprot.org/uniprot/E1V8F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbE subfamily.|||Cell inner membrane http://togogenome.org/gene/768066:HELO_RS08550 ^@ http://purl.uniprot.org/uniprot/E1VCU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/768066:HELO_RS03955 ^@ http://purl.uniprot.org/uniprot/E1V862 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/768066:HELO_RS01255 ^@ http://purl.uniprot.org/uniprot/E1V5K9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/768066:HELO_RS01235 ^@ http://purl.uniprot.org/uniprot/E1V5K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/768066:HELO_RS05115 ^@ http://purl.uniprot.org/uniprot/E1V9J6 ^@ Similarity ^@ Belongs to the GST superfamily. HSP26 family. http://togogenome.org/gene/768066:HELO_RS01290 ^@ http://purl.uniprot.org/uniprot/E1V5L6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS14720 ^@ http://purl.uniprot.org/uniprot/E1V8B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS18940 ^@ http://purl.uniprot.org/uniprot/E1VCG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell inner membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/768066:HELO_RS08555 ^@ http://purl.uniprot.org/uniprot/E1VCU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/768066:HELO_RS00110 ^@ http://purl.uniprot.org/uniprot/E1V467 ^@ Function|||Similarity|||Subunit ^@ Belongs to the serine/threonine dehydratase family.|||Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.|||Homotetramer. http://togogenome.org/gene/768066:HELO_RS15280 ^@ http://purl.uniprot.org/uniprot/E1V8M0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxA subfamily.|||Cytoplasm|||Homotrimer.|||Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/768066:HELO_RS08505 ^@ http://purl.uniprot.org/uniprot/E1VCT1 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. http://togogenome.org/gene/768066:HELO_RS01370 ^@ http://purl.uniprot.org/uniprot/E1V5N2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/768066:HELO_RS08325 ^@ http://purl.uniprot.org/uniprot/E1VCP6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/768066:HELO_RS15180 ^@ http://purl.uniprot.org/uniprot/E1V8K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiJ family.|||Cytoplasm|||Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates. http://togogenome.org/gene/768066:HELO_RS18125 ^@ http://purl.uniprot.org/uniprot/E1VBM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS15605 ^@ http://purl.uniprot.org/uniprot/E1V969 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/768066:HELO_RS00575 ^@ http://purl.uniprot.org/uniprot/E1V4U5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS03655 ^@ http://purl.uniprot.org/uniprot/E1V805 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/768066:HELO_RS14685 ^@ http://purl.uniprot.org/uniprot/E1V8A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS01830 ^@ http://purl.uniprot.org/uniprot/E1V5W8 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/768066:HELO_RS18930 ^@ http://purl.uniprot.org/uniprot/E1VCG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/768066:HELO_RS11380 ^@ http://purl.uniprot.org/uniprot/E1V4K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/768066:HELO_RS03930 ^@ http://purl.uniprot.org/uniprot/E1V857 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS08375 ^@ http://purl.uniprot.org/uniprot/E1VCQ6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/768066:HELO_RS01885 ^@ http://purl.uniprot.org/uniprot/E1V5X8 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/768066:HELO_RS00970 ^@ http://purl.uniprot.org/uniprot/E1V524 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/768066:HELO_RS05135 ^@ http://purl.uniprot.org/uniprot/E1V9K0 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/768066:HELO_RS04210 ^@ http://purl.uniprot.org/uniprot/E1V8P3 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/768066:HELO_RS07870 ^@ http://purl.uniprot.org/uniprot/E1VC46 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/768066:HELO_RS15140 ^@ http://purl.uniprot.org/uniprot/E1V8J2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS11595 ^@ http://purl.uniprot.org/uniprot/E1V4P8 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/768066:HELO_RS13340 ^@ http://purl.uniprot.org/uniprot/E1V6S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/768066:HELO_RS08510 ^@ http://purl.uniprot.org/uniprot/E1VCT2 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/768066:HELO_RS11240 ^@ http://purl.uniprot.org/uniprot/E1V4H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DEAD box helicase family. RhlB subfamily.|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. http://togogenome.org/gene/768066:HELO_RS11495 ^@ http://purl.uniprot.org/uniprot/E1V4M8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/768066:HELO_RS00010 ^@ http://purl.uniprot.org/uniprot/E1V448 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/768066:HELO_RS15435 ^@ http://purl.uniprot.org/uniprot/E1V935 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Monomer. http://togogenome.org/gene/768066:HELO_RS16080 ^@ http://purl.uniprot.org/uniprot/E1V9U5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS15685 ^@ http://purl.uniprot.org/uniprot/E1V985 ^@ Function|||Similarity|||Subunit ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily.|||Interacts with MinC and FtsZ. http://togogenome.org/gene/768066:HELO_RS15965 ^@ http://purl.uniprot.org/uniprot/E1V9D8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS11165 ^@ http://purl.uniprot.org/uniprot/E1V4G4 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/768066:HELO_RS03710 ^@ http://purl.uniprot.org/uniprot/E1V816 ^@ Function|||Similarity ^@ Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.|||Belongs to the Nudix hydrolase family. RppH subfamily. http://togogenome.org/gene/768066:HELO_RS15555 ^@ http://purl.uniprot.org/uniprot/E1V959 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS18890 ^@ http://purl.uniprot.org/uniprot/E1VCF2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS18025 ^@ http://purl.uniprot.org/uniprot/E1VBK3 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Deletion abolishes accumulation of ectoine from the medium.|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell.|||The complex comprises the extracytoplasmic solute receptor protein TeaA, and the two transmembrane proteins TeaB and TeaC. http://togogenome.org/gene/768066:HELO_RS08095 ^@ http://purl.uniprot.org/uniprot/E1VCK6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide. http://togogenome.org/gene/768066:HELO_RS02670 ^@ http://purl.uniprot.org/uniprot/E1V736 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS05215 ^@ http://purl.uniprot.org/uniprot/E1V9L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell inner membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/768066:HELO_RS18820 ^@ http://purl.uniprot.org/uniprot/E1VCD8 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/768066:HELO_RS11330 ^@ http://purl.uniprot.org/uniprot/E1V4J6 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.|||Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). http://togogenome.org/gene/768066:HELO_RS17180 ^@ http://purl.uniprot.org/uniprot/E1VAR5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/768066:HELO_RS15620 ^@ http://purl.uniprot.org/uniprot/E1V972 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/768066:HELO_RS07050 ^@ http://purl.uniprot.org/uniprot/E1VBB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS04740 ^@ http://purl.uniprot.org/uniprot/E1V8Y3 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/768066:HELO_RS10415 ^@ http://purl.uniprot.org/uniprot/E1V3U2 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/768066:HELO_RS14840 ^@ http://purl.uniprot.org/uniprot/E1V8D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS11265 ^@ http://purl.uniprot.org/uniprot/E1V4I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS05180 ^@ http://purl.uniprot.org/uniprot/E1V9K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS00005 ^@ http://purl.uniprot.org/uniprot/E1V447 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/768066:HELO_RS08600 ^@ http://purl.uniprot.org/uniprot/E1VCV0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. UbiG/COQ3 family.|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/768066:HELO_RS18190 ^@ http://purl.uniprot.org/uniprot/E1VBN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS18955 ^@ http://purl.uniprot.org/uniprot/E1VCG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS11375 ^@ http://purl.uniprot.org/uniprot/E1V4K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the R-transferase family. Bpt subfamily.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. http://togogenome.org/gene/768066:HELO_RS05060 ^@ http://purl.uniprot.org/uniprot/E1V9I6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/768066:HELO_RS09615 ^@ http://purl.uniprot.org/uniprot/E1V3F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS04135 ^@ http://purl.uniprot.org/uniprot/E1V893 ^@ Similarity ^@ Belongs to the YjdM family. http://togogenome.org/gene/768066:HELO_RS02910 ^@ http://purl.uniprot.org/uniprot/E1V784 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS18495 ^@ http://purl.uniprot.org/uniprot/E1VC79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FliL family.|||Cell inner membrane|||Controls the rotational direction of flagella during chemotaxis.|||Membrane http://togogenome.org/gene/768066:HELO_RS06650 ^@ http://purl.uniprot.org/uniprot/E1VB37 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/768066:HELO_RS00480 ^@ http://purl.uniprot.org/uniprot/E1V4S7 ^@ Similarity ^@ Belongs to the ferredoxin--NADP reductase type 1 family. http://togogenome.org/gene/768066:HELO_RS04510 ^@ http://purl.uniprot.org/uniprot/E1V8U9 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/768066:HELO_RS01040 ^@ http://purl.uniprot.org/uniprot/E1V538 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/768066:HELO_RS06555 ^@ http://purl.uniprot.org/uniprot/E1VB18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/768066:HELO_RS01225 ^@ http://purl.uniprot.org/uniprot/E1V5K3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/768066:HELO_RS08385 ^@ http://purl.uniprot.org/uniprot/E1VCQ8 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/768066:HELO_RS03855 ^@ http://purl.uniprot.org/uniprot/E1V843 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/768066:HELO_RS08585 ^@ http://purl.uniprot.org/uniprot/E1VCU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CpoB family.|||Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.|||Periplasm http://togogenome.org/gene/768066:HELO_RS01520 ^@ http://purl.uniprot.org/uniprot/E1V5R2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/768066:HELO_RS05130 ^@ http://purl.uniprot.org/uniprot/E1V9J9 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||Homotetramer.|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/768066:HELO_RS06675 ^@ http://purl.uniprot.org/uniprot/E1VB42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/768066:HELO_RS00650 ^@ http://purl.uniprot.org/uniprot/E1V4W0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/768066:HELO_RS14140 ^@ http://purl.uniprot.org/uniprot/E1V7L8 ^@ Function|||Subunit ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).|||Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/768066:HELO_RS15345 ^@ http://purl.uniprot.org/uniprot/E1V917 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/768066:HELO_RS08685 ^@ http://purl.uniprot.org/uniprot/O52249 ^@ Function|||Similarity ^@ Belongs to the acetyltransferase family. EctA subfamily.|||Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. Does not acetylate amino acids like GABA, L-ornithine, L-lysine and L-aspartate. http://togogenome.org/gene/768066:HELO_RS08075 ^@ http://purl.uniprot.org/uniprot/E1VCK2 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/768066:HELO_RS05295 ^@ http://purl.uniprot.org/uniprot/E1V9N2 ^@ Similarity ^@ Belongs to the UPF0434 family. http://togogenome.org/gene/768066:HELO_RS06980 ^@ http://purl.uniprot.org/uniprot/E1VBA2 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carbamylation allows a single lysine to coordinate two nickel ions.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/768066:HELO_RS04825 ^@ http://purl.uniprot.org/uniprot/E1V8Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein PotD/PotF family.|||Periplasm|||Required for the activity of the bacterial periplasmic transport system of putrescine. http://togogenome.org/gene/768066:HELO_RS09940 ^@ http://purl.uniprot.org/uniprot/E1V3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:galactoside symporter (TC 2.A.2) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS14985 ^@ http://purl.uniprot.org/uniprot/E1V8G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OadG family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane|||Heterotrimer of an alpha, a beta and a gamma subunit.|||Membrane http://togogenome.org/gene/768066:HELO_RS16020 ^@ http://purl.uniprot.org/uniprot/E1V9E9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS00965 ^@ http://purl.uniprot.org/uniprot/E1V523 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS11860 ^@ http://purl.uniprot.org/uniprot/E1V582 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.|||Heterooctamer of two A chains, two B chains, two C chains and two D chains.|||Membrane http://togogenome.org/gene/768066:HELO_RS02895 ^@ http://purl.uniprot.org/uniprot/E1V781 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/768066:HELO_RS10075 ^@ http://purl.uniprot.org/uniprot/E1V3M9 ^@ Similarity ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family. http://togogenome.org/gene/768066:HELO_RS18435 ^@ http://purl.uniprot.org/uniprot/E1VBT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/768066:HELO_RS07390 ^@ http://purl.uniprot.org/uniprot/E1VBW2 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/768066:HELO_RS15480 ^@ http://purl.uniprot.org/uniprot/E1V944 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoH subfamily.|||Cytoplasm|||Interacts with the RNA polymerase core enzyme.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. http://togogenome.org/gene/768066:HELO_RS05360 ^@ http://purl.uniprot.org/uniprot/E1V9P4 ^@ Function|||Similarity ^@ Belongs to the DUF177 domain family.|||Plays a role in synthesis, processing and/or stability of 23S rRNA. http://togogenome.org/gene/768066:HELO_RS00765 ^@ http://purl.uniprot.org/uniprot/E1V4Y3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS12110 ^@ http://purl.uniprot.org/uniprot/E1V5C9 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/768066:HELO_RS02205 ^@ http://purl.uniprot.org/uniprot/E1V6H2 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family. AstD subfamily.|||Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. http://togogenome.org/gene/768066:HELO_RS06880 ^@ http://purl.uniprot.org/uniprot/E1VB83 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/768066:HELO_RS09435 ^@ http://purl.uniprot.org/uniprot/E1V3B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Cell inner membrane|||Cell membrane|||Membrane|||Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine. http://togogenome.org/gene/768066:HELO_RS13035 ^@ http://purl.uniprot.org/uniprot/E1V678 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/768066:HELO_RS13550 ^@ http://purl.uniprot.org/uniprot/E1V6X0 ^@ Function|||Similarity ^@ Belongs to the esterase D family.|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/768066:HELO_RS14500 ^@ http://purl.uniprot.org/uniprot/E1V7T5 ^@ Similarity ^@ Belongs to the phosphate/phosphite/phosphonate binding protein family. http://togogenome.org/gene/768066:HELO_RS00440 ^@ http://purl.uniprot.org/uniprot/E1V4D1 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Homodimer.|||Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.|||The transmembrane domain is a dimerization domain. http://togogenome.org/gene/768066:HELO_RS01665 ^@ http://purl.uniprot.org/uniprot/E1V5U0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/768066:HELO_RS09495 ^@ http://purl.uniprot.org/uniprot/E1V3C7 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/768066:HELO_RS17970 ^@ http://purl.uniprot.org/uniprot/E1VBJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS01280 ^@ http://purl.uniprot.org/uniprot/E1V5L4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS11630 ^@ http://purl.uniprot.org/uniprot/E1V4Q5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/768066:HELO_RS11175 ^@ http://purl.uniprot.org/uniprot/E1V4G6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/768066:HELO_RS18655 ^@ http://purl.uniprot.org/uniprot/E1VCA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/768066:HELO_RS01625 ^@ http://purl.uniprot.org/uniprot/E1V5T2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/768066:HELO_RS15160 ^@ http://purl.uniprot.org/uniprot/E1V8J6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/768066:HELO_RS11670 ^@ http://purl.uniprot.org/uniprot/E1V4R3 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/768066:HELO_RS17275 ^@ http://purl.uniprot.org/uniprot/E1VAT2 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/768066:HELO_RS13605 ^@ http://purl.uniprot.org/uniprot/E1V6Y1 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/768066:HELO_RS14440 ^@ http://purl.uniprot.org/uniprot/E1V7S4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IlvD/Edd family.|||Binds 1 [4Fe-4S] cluster.|||Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate. http://togogenome.org/gene/768066:HELO_RS16250 ^@ http://purl.uniprot.org/uniprot/E1V9X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS11905 ^@ http://purl.uniprot.org/uniprot/E1V591 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.|||Homohexamer; trimer of homodimers. http://togogenome.org/gene/768066:HELO_RS02900 ^@ http://purl.uniprot.org/uniprot/E1V782 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS01390 ^@ http://purl.uniprot.org/uniprot/E1V5N6 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/768066:HELO_RS18995 ^@ http://purl.uniprot.org/uniprot/E1VCH3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HesB/IscA family.|||Binds 1 iron-sulfur cluster per subunit.|||Homodimer.|||Required for insertion of 4Fe-4S clusters for at least IspG. http://togogenome.org/gene/768066:HELO_RS01270 ^@ http://purl.uniprot.org/uniprot/E1V5L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/768066:HELO_RS15310 ^@ http://purl.uniprot.org/uniprot/E1V8M6 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS16460 ^@ http://purl.uniprot.org/uniprot/E1VA16 ^@ Function|||Similarity ^@ Belongs to the Fe(2+)-trafficking protein family.|||Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. http://togogenome.org/gene/768066:HELO_RS12995 ^@ http://purl.uniprot.org/uniprot/E1V670 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/768066:HELO_RS11220 ^@ http://purl.uniprot.org/uniprot/E1V4H5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/768066:HELO_RS12365 ^@ http://purl.uniprot.org/uniprot/E1V5I0 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/768066:HELO_RS11415 ^@ http://purl.uniprot.org/uniprot/E1V4L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HflD family.|||Cell inner membrane|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS03505 ^@ http://purl.uniprot.org/uniprot/E1V7Y4 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/768066:HELO_RS12310 ^@ http://purl.uniprot.org/uniprot/E1V5G9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/768066:HELO_RS13865 ^@ http://purl.uniprot.org/uniprot/E1V731 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/768066:HELO_RS04175 ^@ http://purl.uniprot.org/uniprot/E1V8N6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS01335 ^@ http://purl.uniprot.org/uniprot/E1V5M5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS04120 ^@ http://purl.uniprot.org/uniprot/E1V890 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS06845 ^@ http://purl.uniprot.org/uniprot/E1VB76 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/768066:HELO_RS18570 ^@ http://purl.uniprot.org/uniprot/E1VC93 ^@ Function|||Similarity ^@ Belongs to the FlgD family.|||Required for flagellar hook formation. May act as a scaffolding protein. http://togogenome.org/gene/768066:HELO_RS06745 ^@ http://purl.uniprot.org/uniprot/E1VB56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/768066:HELO_RS15755 ^@ http://purl.uniprot.org/uniprot/E1V998 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LysR transcriptional regulatory family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS04550 ^@ http://purl.uniprot.org/uniprot/E1V8V7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.|||Cell inner membrane|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB). http://togogenome.org/gene/768066:HELO_RS16015 ^@ http://purl.uniprot.org/uniprot/E1V9E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS01415 ^@ http://purl.uniprot.org/uniprot/E1V5P1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioester dehydratase family. FabA subfamily.|||Cytoplasm|||Homodimer.|||Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. http://togogenome.org/gene/768066:HELO_RS16440 ^@ http://purl.uniprot.org/uniprot/E1VA12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS11285 ^@ http://purl.uniprot.org/uniprot/E1V4I8 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/768066:HELO_RS16985 ^@ http://purl.uniprot.org/uniprot/E1VAN3 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/768066:HELO_RS19065 ^@ http://purl.uniprot.org/uniprot/E1VCI7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/768066:HELO_RS07420 ^@ http://purl.uniprot.org/uniprot/E1VBW8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LpxH family.|||Binds 2 Mn(2+) ions per subunit in a binuclear metal center.|||Cell inner membrane|||Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/768066:HELO_RS07955 ^@ http://purl.uniprot.org/uniprot/E1VC63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS18310 ^@ http://purl.uniprot.org/uniprot/E1VBQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/768066:HELO_RS14630 ^@ http://purl.uniprot.org/uniprot/E1V7W1 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24 family.|||Cells lacking this gene are unable to grow on ectoine as carbon source.|||Cytoplasm|||Involved in the degradation of ectoine, which allows H.elongata to utilize ectoine as both a carbon and a nitrogen source for growth. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4-diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4-diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-Ac-DABA is the essential substrate for the subsequent catabolic enzyme DoeB.|||The ectoine biosynthesis and ectoine degradation operate via different isoforms of N-acetyl diamonbutyric acid: N-gamma-acetyl diamonbutyric acid is the intermediate of ectoine biosynthesis and N-alpha-acetyl diamonbutyric acid is the intermediate of ectoine degradation. http://togogenome.org/gene/768066:HELO_RS08645 ^@ http://purl.uniprot.org/uniprot/E1VCV9 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS05560 ^@ http://purl.uniprot.org/uniprot/E1V9S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS04925 ^@ http://purl.uniprot.org/uniprot/E1V9G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/768066:HELO_RS12165 ^@ http://purl.uniprot.org/uniprot/E1V5E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS15195 ^@ http://purl.uniprot.org/uniprot/E1V8K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell inner membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/768066:HELO_RS07500 ^@ http://purl.uniprot.org/uniprot/E1VBY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS08560 ^@ http://purl.uniprot.org/uniprot/E1VCU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbB/TolQ family.|||Cell inner membrane|||Membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/768066:HELO_RS04810 ^@ http://purl.uniprot.org/uniprot/E1V8Z6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/768066:HELO_RS05370 ^@ http://purl.uniprot.org/uniprot/E1V9P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/768066:HELO_RS12140 ^@ http://purl.uniprot.org/uniprot/E1V5D5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS05090 ^@ http://purl.uniprot.org/uniprot/E1V9J1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/768066:HELO_RS00125 ^@ http://purl.uniprot.org/uniprot/E1V469 ^@ Function|||Similarity|||Subunit ^@ Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.|||Belongs to the ZapA family. Type 1 subfamily.|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/768066:HELO_RS08260 ^@ http://purl.uniprot.org/uniprot/E1VCN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX11/CtaG family.|||Cell inner membrane|||Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. http://togogenome.org/gene/768066:HELO_RS02000 ^@ http://purl.uniprot.org/uniprot/E1V6D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Cytoplasm|||Homodimer.|||Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. http://togogenome.org/gene/768066:HELO_RS01340 ^@ http://purl.uniprot.org/uniprot/E1V5M6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS12845 ^@ http://purl.uniprot.org/uniprot/E1V640 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/768066:HELO_RS18065 ^@ http://purl.uniprot.org/uniprot/E1VBL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/768066:HELO_RS03680 ^@ http://purl.uniprot.org/uniprot/E1V810 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DsbB family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein. http://togogenome.org/gene/768066:HELO_RS13410 ^@ http://purl.uniprot.org/uniprot/E1V6U3 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/768066:HELO_RS02905 ^@ http://purl.uniprot.org/uniprot/E1V783 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS09445 ^@ http://purl.uniprot.org/uniprot/E1V3B7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DNA gyrase inhibitor YacG family.|||Binds 1 zinc ion.|||Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.|||Interacts with GyrB. http://togogenome.org/gene/768066:HELO_RS05750 ^@ http://purl.uniprot.org/uniprot/E1VAA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/768066:HELO_RS14815 ^@ http://purl.uniprot.org/uniprot/E1V8D0 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/768066:HELO_RS02685 ^@ http://purl.uniprot.org/uniprot/E1V739 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/768066:HELO_RS08120 ^@ http://purl.uniprot.org/uniprot/E1VCL1 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS00520 ^@ http://purl.uniprot.org/uniprot/E1V4T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiK family.|||Cytoplasm|||Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. http://togogenome.org/gene/768066:HELO_RS00015 ^@ http://purl.uniprot.org/uniprot/E1V449 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/768066:HELO_RS13005 ^@ http://purl.uniprot.org/uniprot/E1V672 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS06600 ^@ http://purl.uniprot.org/uniprot/E1VB27 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS18555 ^@ http://purl.uniprot.org/uniprot/E1VC90 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/768066:HELO_RS06570 ^@ http://purl.uniprot.org/uniprot/E1VB21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell inner membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/768066:HELO_RS05450 ^@ http://purl.uniprot.org/uniprot/E1V9R2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS05160 ^@ http://purl.uniprot.org/uniprot/E1V9K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsL family.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.|||Membrane|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/768066:HELO_RS05385 ^@ http://purl.uniprot.org/uniprot/E1V9P9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS15775 ^@ http://purl.uniprot.org/uniprot/E1V9A2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/768066:HELO_RS05265 ^@ http://purl.uniprot.org/uniprot/E1V9M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/768066:HELO_RS06155 ^@ http://purl.uniprot.org/uniprot/E1VAG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/768066:HELO_RS11030 ^@ http://purl.uniprot.org/uniprot/E1V4D9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.|||Cell inner membrane|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. http://togogenome.org/gene/768066:HELO_RS01220 ^@ http://purl.uniprot.org/uniprot/E1V5K2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/768066:HELO_RS04675 ^@ http://purl.uniprot.org/uniprot/E1V8X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS13580 ^@ http://purl.uniprot.org/uniprot/E1V6X6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/768066:HELO_RS04855 ^@ http://purl.uniprot.org/uniprot/E1V905 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/768066:HELO_RS17030 ^@ http://purl.uniprot.org/uniprot/E1VAP0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/768066:HELO_RS00475 ^@ http://purl.uniprot.org/uniprot/E1V4S6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS14245 ^@ http://purl.uniprot.org/uniprot/E1V7N8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/768066:HELO_RS13110 ^@ http://purl.uniprot.org/uniprot/E1V692 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscS (TC 1.A.23) family.|||Cell inner membrane|||Homoheptamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.|||Membrane http://togogenome.org/gene/768066:HELO_RS13635 ^@ http://purl.uniprot.org/uniprot/E1V6Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/768066:HELO_RS05155 ^@ http://purl.uniprot.org/uniprot/E1V9K3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/768066:HELO_RS11865 ^@ http://purl.uniprot.org/uniprot/E1V583 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Heterooctamer of two A chains, two B chains, two C chains and two D chains.|||Membrane http://togogenome.org/gene/768066:HELO_RS08695 ^@ http://purl.uniprot.org/uniprot/O52251 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the ectoine synthase family.|||Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant. Does not act on N-acetylated amino acids like N-alpha-acetyl-L-asparagine,N-alpha-acetyl-L-ornithine, N-alpha-acetyl-L-lysine and N-epsilon-acetyl-L-lysine.|||Seems to require potassium ions for its activity and stability. Slightly inhibited by N-ethylmaleimide. http://togogenome.org/gene/768066:HELO_RS06485 ^@ http://purl.uniprot.org/uniprot/E1VB04 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/768066:HELO_RS07995 ^@ http://purl.uniprot.org/uniprot/E1VC71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/768066:HELO_RS01180 ^@ http://purl.uniprot.org/uniprot/E1V557 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS18760 ^@ http://purl.uniprot.org/uniprot/E1VCC7 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/768066:HELO_RS03700 ^@ http://purl.uniprot.org/uniprot/E1V814 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/768066:HELO_RS14215 ^@ http://purl.uniprot.org/uniprot/E1V7N2 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). http://togogenome.org/gene/768066:HELO_RS15445 ^@ http://purl.uniprot.org/uniprot/E1V937 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/768066:HELO_RS06545 ^@ http://purl.uniprot.org/uniprot/E1VB16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS06250 ^@ http://purl.uniprot.org/uniprot/E1VAI1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/768066:HELO_RS13615 ^@ http://purl.uniprot.org/uniprot/E1V6Y3 ^@ Function|||Miscellaneous|||Similarity ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. http://togogenome.org/gene/768066:HELO_RS17290 ^@ http://purl.uniprot.org/uniprot/E1VAT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/768066:HELO_RS05195 ^@ http://purl.uniprot.org/uniprot/E1V9L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). http://togogenome.org/gene/768066:HELO_RS17665 ^@ http://purl.uniprot.org/uniprot/E1VAZ3 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/768066:HELO_RS14225 ^@ http://purl.uniprot.org/uniprot/E1V7N4 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/768066:HELO_RS04955 ^@ http://purl.uniprot.org/uniprot/E1V9G6 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/768066:HELO_RS18020 ^@ http://purl.uniprot.org/uniprot/E1VBK2 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Deletion abolishes accumulation of ectoine from the medium.|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell.|||The complex comprises the extracytoplasmic solute receptor protein TeaA, and the two transmembrane proteins TeaB and TeaC. http://togogenome.org/gene/768066:HELO_RS07425 ^@ http://purl.uniprot.org/uniprot/E1VBW9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/768066:HELO_RS05515 ^@ http://purl.uniprot.org/uniprot/E1V9R9 ^@ Cofactor|||Similarity ^@ Belongs to the nitroreductase family.|||Binds 1 FMN per subunit. http://togogenome.org/gene/768066:HELO_RS14730 ^@ http://purl.uniprot.org/uniprot/E1V8B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.|||Periplasm http://togogenome.org/gene/768066:HELO_RS02105 ^@ http://purl.uniprot.org/uniprot/E1V6F3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/768066:HELO_RS11880 ^@ http://purl.uniprot.org/uniprot/E1V586 ^@ Similarity ^@ Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family. http://togogenome.org/gene/768066:HELO_RS18315 ^@ http://purl.uniprot.org/uniprot/E1VBQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sigma-70 factor family. FliA subfamily.|||Cytoplasm|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. http://togogenome.org/gene/768066:HELO_RS15575 ^@ http://purl.uniprot.org/uniprot/E1V963 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS14530 ^@ http://purl.uniprot.org/uniprot/E1V7U2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/768066:HELO_RS01670 ^@ http://purl.uniprot.org/uniprot/E1V5U1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/768066:HELO_RS09370 ^@ http://purl.uniprot.org/uniprot/E1V3A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS11155 ^@ http://purl.uniprot.org/uniprot/E1V4G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/768066:HELO_RS00960 ^@ http://purl.uniprot.org/uniprot/E1V522 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/768066:HELO_RS00455 ^@ http://purl.uniprot.org/uniprot/E1V4D4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/768066:HELO_RS15190 ^@ http://purl.uniprot.org/uniprot/E1V8K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS18390 ^@ http://purl.uniprot.org/uniprot/E1VBS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FlhC family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.|||Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers. http://togogenome.org/gene/768066:HELO_RS06710 ^@ http://purl.uniprot.org/uniprot/E1VB49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LptE lipoprotein family.|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.|||Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. http://togogenome.org/gene/768066:HELO_RS17160 ^@ http://purl.uniprot.org/uniprot/E1VAR1 ^@ Function|||Similarity ^@ Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/768066:HELO_RS16240 ^@ http://purl.uniprot.org/uniprot/E1V9X3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/768066:HELO_RS11100 ^@ http://purl.uniprot.org/uniprot/E1V4F1 ^@ Similarity ^@ Belongs to the phosphate/phosphite/phosphonate binding protein family. http://togogenome.org/gene/768066:HELO_RS13020 ^@ http://purl.uniprot.org/uniprot/E1V675 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/768066:HELO_RS17960 ^@ http://purl.uniprot.org/uniprot/E1VBJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbA subfamily.|||Periplasm http://togogenome.org/gene/768066:HELO_RS10450 ^@ http://purl.uniprot.org/uniprot/E1V3U8 ^@ Caution|||Function|||Similarity ^@ Belongs to the globin family. Two-domain flavohemoproteins subfamily.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS13565 ^@ http://purl.uniprot.org/uniprot/E1V6X3 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/768066:HELO_RS17165 ^@ http://purl.uniprot.org/uniprot/E1VAR2 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/768066:HELO_RS05645 ^@ http://purl.uniprot.org/uniprot/E1VA81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ElaB/YgaM/YqjD family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS07385 ^@ http://purl.uniprot.org/uniprot/E1VBW1 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/768066:HELO_RS08885 ^@ http://purl.uniprot.org/uniprot/E1V331 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrE/TusD family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS17210 ^@ http://purl.uniprot.org/uniprot/E1VAS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/768066:HELO_RS17355 ^@ http://purl.uniprot.org/uniprot/E1VAU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Fur family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/768066:HELO_RS15045 ^@ http://purl.uniprot.org/uniprot/E1V8H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS18915 ^@ http://purl.uniprot.org/uniprot/E1VCF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/768066:HELO_RS17980 ^@ http://purl.uniprot.org/uniprot/E1VBJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 7 family.|||Homodimer.|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||Periplasm http://togogenome.org/gene/768066:HELO_RS13420 ^@ http://purl.uniprot.org/uniprot/E1V6U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Cob(I)alamin adenosyltransferase family.|||Cytoplasm|||Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. http://togogenome.org/gene/768066:HELO_RS05055 ^@ http://purl.uniprot.org/uniprot/E1V9I5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS08720 ^@ http://purl.uniprot.org/uniprot/E1VCX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS01205 ^@ http://purl.uniprot.org/uniprot/E1V5J9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/768066:HELO_RS00665 ^@ http://purl.uniprot.org/uniprot/E1V4W3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. http://togogenome.org/gene/768066:HELO_RS07025 ^@ http://purl.uniprot.org/uniprot/E1VBB1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS18725 ^@ http://purl.uniprot.org/uniprot/E1VCC0 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/768066:HELO_RS02810 ^@ http://purl.uniprot.org/uniprot/E1V764 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/768066:HELO_RS09545 ^@ http://purl.uniprot.org/uniprot/E1V3D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0394 family.|||Membrane http://togogenome.org/gene/768066:HELO_RS15335 ^@ http://purl.uniprot.org/uniprot/E1V8N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS13590 ^@ http://purl.uniprot.org/uniprot/E1V6X8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/768066:HELO_RS15245 ^@ http://purl.uniprot.org/uniprot/E1V8L3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure. http://togogenome.org/gene/768066:HELO_RS16435 ^@ http://purl.uniprot.org/uniprot/E1VA11 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/768066:HELO_RS00490 ^@ http://purl.uniprot.org/uniprot/E1V4S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS18985 ^@ http://purl.uniprot.org/uniprot/E1VCH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS01355 ^@ http://purl.uniprot.org/uniprot/E1V5M9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/768066:HELO_RS00515 ^@ http://purl.uniprot.org/uniprot/E1V4T4 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/768066:HELO_RS05075 ^@ http://purl.uniprot.org/uniprot/E1V9I9 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/768066:HELO_RS07570 ^@ http://purl.uniprot.org/uniprot/E1VBZ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS14150 ^@ http://purl.uniprot.org/uniprot/E1V7M0 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/768066:HELO_RS03885 ^@ http://purl.uniprot.org/uniprot/A0A1R4A458 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.|||May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA. http://togogenome.org/gene/768066:HELO_RS05350 ^@ http://purl.uniprot.org/uniprot/E1V9P2 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/768066:HELO_RS15520 ^@ http://purl.uniprot.org/uniprot/E1V952 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/768066:HELO_RS10820 ^@ http://purl.uniprot.org/uniprot/E1V409 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS13620 ^@ http://purl.uniprot.org/uniprot/E1V6Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GlpE family.|||Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS14365 ^@ http://purl.uniprot.org/uniprot/E1V7Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS01725 ^@ http://purl.uniprot.org/uniprot/E1V5V2 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/768066:HELO_RS05390 ^@ http://purl.uniprot.org/uniprot/E1V9Q0 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/768066:HELO_RS17750 ^@ http://purl.uniprot.org/uniprot/E1VBF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS04910 ^@ http://purl.uniprot.org/uniprot/E1V9F7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/768066:HELO_RS01360 ^@ http://purl.uniprot.org/uniprot/E1V5N0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/768066:HELO_RS16320 ^@ http://purl.uniprot.org/uniprot/E1V9Y8 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/768066:HELO_RS15415 ^@ http://purl.uniprot.org/uniprot/E1V931 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AlaDH/PNT family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reductive amination of pyruvate to L-alanine. http://togogenome.org/gene/768066:HELO_RS05100 ^@ http://purl.uniprot.org/uniprot/E1V9J3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The Rieske protein is a high potential 2Fe-2S protein.|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/768066:HELO_RS05465 ^@ http://purl.uniprot.org/uniprot/E1V9R5 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/768066:HELO_RS11320 ^@ http://purl.uniprot.org/uniprot/E1V4J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/768066:HELO_RS15365 ^@ http://purl.uniprot.org/uniprot/E1V921 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.|||Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.|||Cytoplasm|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS08575 ^@ http://purl.uniprot.org/uniprot/E1VCU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TolB family.|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||Periplasm|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/768066:HELO_RS11500 ^@ http://purl.uniprot.org/uniprot/E1V4M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/768066:HELO_RS18910 ^@ http://purl.uniprot.org/uniprot/E1VCF6 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/768066:HELO_RS08890 ^@ http://purl.uniprot.org/uniprot/E1V332 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/768066:HELO_RS03685 ^@ http://purl.uniprot.org/uniprot/E1V811 ^@ Similarity ^@ Belongs to the Rsd/AlgQ family. http://togogenome.org/gene/768066:HELO_RS06970 ^@ http://purl.uniprot.org/uniprot/E1VBA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/768066:HELO_RS16295 ^@ http://purl.uniprot.org/uniprot/E1V9Y4 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/768066:HELO_RS03065 ^@ http://purl.uniprot.org/uniprot/E1V7B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS04870 ^@ http://purl.uniprot.org/uniprot/E1V908 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/768066:HELO_RS12145 ^@ http://purl.uniprot.org/uniprot/E1V5D6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS00095 ^@ http://purl.uniprot.org/uniprot/E1V464 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.|||Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.|||Homodimer.|||In the C-terminal section; belongs to the cytidylyltransferase family.|||In the N-terminal section; belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/768066:HELO_RS01265 ^@ http://purl.uniprot.org/uniprot/E1V5L1 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/768066:HELO_RS01250 ^@ http://purl.uniprot.org/uniprot/E1V5K8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS13850 ^@ http://purl.uniprot.org/uniprot/E1V728 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/768066:HELO_RS02085 ^@ http://purl.uniprot.org/uniprot/E1V6E9 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/768066:HELO_RS15075 ^@ http://purl.uniprot.org/uniprot/E1V8H9 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/768066:HELO_RS01330 ^@ http://purl.uniprot.org/uniprot/E1V5M4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/768066:HELO_RS01200 ^@ http://purl.uniprot.org/uniprot/E1V5J8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/768066:HELO_RS02045 ^@ http://purl.uniprot.org/uniprot/E1V6E1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/768066:HELO_RS16160 ^@ http://purl.uniprot.org/uniprot/E1V9W1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS18385 ^@ http://purl.uniprot.org/uniprot/E1VBS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/768066:HELO_RS02350 ^@ http://purl.uniprot.org/uniprot/E1V6K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS04785 ^@ http://purl.uniprot.org/uniprot/E1V8Z1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/768066:HELO_RS16430 ^@ http://purl.uniprot.org/uniprot/E1VA10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS08265 ^@ http://purl.uniprot.org/uniprot/E1VCN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS07340 ^@ http://purl.uniprot.org/uniprot/E1VBV5 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.|||Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. http://togogenome.org/gene/768066:HELO_RS13280 ^@ http://purl.uniprot.org/uniprot/E1V6R7 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. http://togogenome.org/gene/768066:HELO_RS14180 ^@ http://purl.uniprot.org/uniprot/E1V7M6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/768066:HELO_RS09600 ^@ http://purl.uniprot.org/uniprot/E1V3E8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/768066:HELO_RS17990 ^@ http://purl.uniprot.org/uniprot/E1VBJ7 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/768066:HELO_RS18970 ^@ http://purl.uniprot.org/uniprot/E1VCG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. http://togogenome.org/gene/768066:HELO_RS02115 ^@ http://purl.uniprot.org/uniprot/E1V6F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane|||Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).|||The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. http://togogenome.org/gene/768066:HELO_RS06985 ^@ http://purl.uniprot.org/uniprot/E1VBA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UreE family.|||Cytoplasm|||Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. http://togogenome.org/gene/768066:HELO_RS11625 ^@ http://purl.uniprot.org/uniprot/E1V4Q4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/768066:HELO_RS08240 ^@ http://purl.uniprot.org/uniprot/E1VCN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS08770 ^@ http://purl.uniprot.org/uniprot/E1V309 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NfuA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.|||Homodimer.|||Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. http://togogenome.org/gene/768066:HELO_RS01915 ^@ http://purl.uniprot.org/uniprot/E1V6B7 ^@ Function|||Similarity ^@ Belongs to the bacterioferritin family.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/768066:HELO_RS00505 ^@ http://purl.uniprot.org/uniprot/E1V4T2 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/768066:HELO_RS06590 ^@ http://purl.uniprot.org/uniprot/E1VB25 ^@ Similarity ^@ Belongs to the UPF0250 family. http://togogenome.org/gene/768066:HELO_RS07075 ^@ http://purl.uniprot.org/uniprot/E1VBC1 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/768066:HELO_RS08445 ^@ http://purl.uniprot.org/uniprot/E1VCS0 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/768066:HELO_RS07375 ^@ http://purl.uniprot.org/uniprot/E1VBV9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/768066:HELO_RS14625 ^@ http://purl.uniprot.org/uniprot/E1V7W0 ^@ Cofactor|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DoeB deacetylase family.|||Binds 1 zinc ion per subunit.|||Cells lacking this gene are unable to grow on ectoine as carbon and nitrogen sources and accumulate N-alpha-acetyl-L-2,4-diaminobutyrate (N-alpha-Ac-DABA).|||Cytoplasm|||Involved in the degradation of ectoine, which allows H.elongata to utilize ectoine as both a carbon and a nitrogen source for growth. Catalyzes the deacetylation of N-alpha-acetyl-L-2,4-diaminobutyrate (N-alpha-Ac-DABA) to yield L-2,4-diaminobutyrate (DABA). http://togogenome.org/gene/768066:HELO_RS13080 ^@ http://purl.uniprot.org/uniprot/E1V686 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/768066:HELO_RS15390 ^@ http://purl.uniprot.org/uniprot/E1V926 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/768066:HELO_RS06885 ^@ http://purl.uniprot.org/uniprot/E1VB84 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/768066:HELO_RS11910 ^@ http://purl.uniprot.org/uniprot/E1V592 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/768066:HELO_RS04750 ^@ http://purl.uniprot.org/uniprot/E1V8Y5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/768066:HELO_RS10310 ^@ http://purl.uniprot.org/uniprot/E1V3S1 ^@ Similarity ^@ Belongs to the SdhE FAD assembly factor family. http://togogenome.org/gene/768066:HELO_RS01305 ^@ http://purl.uniprot.org/uniprot/E1V5L9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/768066:HELO_RS18830 ^@ http://purl.uniprot.org/uniprot/E1VCE0 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/768066:HELO_RS01230 ^@ http://purl.uniprot.org/uniprot/E1V5K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS08185 ^@ http://purl.uniprot.org/uniprot/E1VCM1 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/768066:HELO_RS18855 ^@ http://purl.uniprot.org/uniprot/E1VCE5 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Electron transport system for the ribonucleotide reductase system NrdEF. http://togogenome.org/gene/768066:HELO_RS18870 ^@ http://purl.uniprot.org/uniprot/E1VCE8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/768066:HELO_RS15340 ^@ http://purl.uniprot.org/uniprot/E1V916 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/768066:HELO_RS08690 ^@ http://purl.uniprot.org/uniprot/O52250 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. Seems to use L-glutamate specifically as the amino group donor to ASA, as it is not active with L-alanine, L-glutamine, L-aspartate and L-lysine, and is only poorly active with L-homoserine. In the reverse reaction, gamma-aminobutyric acid (GABA) and L-ornithine can also be used as amino group donors to 2-oxoglutarate, but with a reduced activity compared to that with DABA.|||Homohexamer. http://togogenome.org/gene/768066:HELO_RS03240 ^@ http://purl.uniprot.org/uniprot/E1V7E9 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/768066:HELO_RS03250 ^@ http://purl.uniprot.org/uniprot/E1V7F1 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. ArgA subfamily.|||Cytoplasm|||In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role. http://togogenome.org/gene/768066:HELO_RS07380 ^@ http://purl.uniprot.org/uniprot/E1VBW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/768066:HELO_RS02815 ^@ http://purl.uniprot.org/uniprot/E1V765 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/768066:HELO_RS08330 ^@ http://purl.uniprot.org/uniprot/E1VCP7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/768066:HELO_RS00305 ^@ http://purl.uniprot.org/uniprot/E1V4A5 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/768066:HELO_RS07105 ^@ http://purl.uniprot.org/uniprot/E1VBC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS08440 ^@ http://purl.uniprot.org/uniprot/E1VCR9 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/768066:HELO_RS00770 ^@ http://purl.uniprot.org/uniprot/E1V4Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS18520 ^@ http://purl.uniprot.org/uniprot/E1VC83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/768066:HELO_RS18925 ^@ http://purl.uniprot.org/uniprot/E1VCF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/768066:HELO_RS10350 ^@ http://purl.uniprot.org/uniprot/E1V3S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/768066:HELO_RS16275 ^@ http://purl.uniprot.org/uniprot/E1V9Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/768066:HELO_RS08145 ^@ http://purl.uniprot.org/uniprot/E1VCL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS15060 ^@ http://purl.uniprot.org/uniprot/E1V8H6 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/768066:HELO_RS06780 ^@ http://purl.uniprot.org/uniprot/E1VB63 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS09985 ^@ http://purl.uniprot.org/uniprot/E1V3L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/768066:HELO_RS13845 ^@ http://purl.uniprot.org/uniprot/E1V727 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. http://togogenome.org/gene/768066:HELO_RS13820 ^@ http://purl.uniprot.org/uniprot/E1V723 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS01640 ^@ http://purl.uniprot.org/uniprot/E1V5T5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/768066:HELO_RS06605 ^@ http://purl.uniprot.org/uniprot/E1VB28 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS18580 ^@ http://purl.uniprot.org/uniprot/E1VC95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.|||The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. http://togogenome.org/gene/768066:HELO_RS15440 ^@ http://purl.uniprot.org/uniprot/E1V936 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/768066:HELO_RS17105 ^@ http://purl.uniprot.org/uniprot/E1VAQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS13440 ^@ http://purl.uniprot.org/uniprot/E1V6U9 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/768066:HELO_RS15295 ^@ http://purl.uniprot.org/uniprot/E1V8M3 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/768066:HELO_RS01375 ^@ http://purl.uniprot.org/uniprot/E1V5N3 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/768066:HELO_RS13815 ^@ http://purl.uniprot.org/uniprot/E1V722 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS01320 ^@ http://purl.uniprot.org/uniprot/E1V5M2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/768066:HELO_RS02885 ^@ http://purl.uniprot.org/uniprot/E1V779 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/768066:HELO_RS01760 ^@ http://purl.uniprot.org/uniprot/E1V5V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/768066:HELO_RS11005 ^@ http://purl.uniprot.org/uniprot/E1V443 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS05720 ^@ http://purl.uniprot.org/uniprot/E1VA94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/768066:HELO_RS13675 ^@ http://purl.uniprot.org/uniprot/E1V6Z5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS01185 ^@ http://purl.uniprot.org/uniprot/E1V558 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/768066:HELO_RS01715 ^@ http://purl.uniprot.org/uniprot/E1V5V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamD family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/768066:HELO_RS16400 ^@ http://purl.uniprot.org/uniprot/E1VA04 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PhyH family. EctD subfamily.|||Binds 1 Fe(2+) ion.|||Homodimer.|||Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. http://togogenome.org/gene/768066:HELO_RS16265 ^@ http://purl.uniprot.org/uniprot/E1V9X8 ^@ Function ^@ Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. http://togogenome.org/gene/768066:HELO_RS13910 ^@ http://purl.uniprot.org/uniprot/E1V7H8 ^@ Similarity ^@ Belongs to the UPF0229 family. http://togogenome.org/gene/768066:HELO_RS09280 ^@ http://purl.uniprot.org/uniprot/E1V384 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/768066:HELO_RS04815 ^@ http://purl.uniprot.org/uniprot/E1V8Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/768066:HELO_RS14940 ^@ http://purl.uniprot.org/uniprot/E1V8F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmD/CycX/HelD family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/768066:HELO_RS13730 ^@ http://purl.uniprot.org/uniprot/E1V705 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/768066:HELO_RS09605 ^@ http://purl.uniprot.org/uniprot/E1V3E9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase T family.|||Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.|||Homodimer.|||Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. http://togogenome.org/gene/768066:HELO_RS02075 ^@ http://purl.uniprot.org/uniprot/E1V6E7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/768066:HELO_RS06875 ^@ http://purl.uniprot.org/uniprot/E1VB82 ^@ Similarity ^@ Belongs to the CFA/CMAS family. http://togogenome.org/gene/768066:HELO_RS03010 ^@ http://purl.uniprot.org/uniprot/E1V7A4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/768066:HELO_RS01195 ^@ http://purl.uniprot.org/uniprot/E1V5J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/768066:HELO_RS11180 ^@ http://purl.uniprot.org/uniprot/E1V4G7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/768066:HELO_RS00595 ^@ http://purl.uniprot.org/uniprot/E1V4U9 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS17240 ^@ http://purl.uniprot.org/uniprot/E1VAS5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/768066:HELO_RS02430 ^@ http://purl.uniprot.org/uniprot/E1V6L4 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/768066:HELO_RS07495 ^@ http://purl.uniprot.org/uniprot/E1VBY2 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/768066:HELO_RS01240 ^@ http://purl.uniprot.org/uniprot/E1V5K6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/768066:HELO_RS02025 ^@ http://purl.uniprot.org/uniprot/E1V6D7 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/768066:HELO_RS01315 ^@ http://purl.uniprot.org/uniprot/E1V5M1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/768066:HELO_RS01905 ^@ http://purl.uniprot.org/uniprot/E1V6B5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/768066:HELO_RS15370 ^@ http://purl.uniprot.org/uniprot/E1V922 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M20A family. DapE subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.|||Homodimer. http://togogenome.org/gene/768066:HELO_RS02280 ^@ http://purl.uniprot.org/uniprot/E1V6I7 ^@ Similarity ^@ Belongs to the nitroreductase family. http://togogenome.org/gene/768066:HELO_RS11650 ^@ http://purl.uniprot.org/uniprot/E1V4Q9 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/768066:HELO_RS00320 ^@ http://purl.uniprot.org/uniprot/E1V4A8 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/768066:HELO_RS01190 ^@ http://purl.uniprot.org/uniprot/E1V5J6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/768066:HELO_RS00385 ^@ http://purl.uniprot.org/uniprot/E1V4C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/768066:HELO_RS15070 ^@ http://purl.uniprot.org/uniprot/E1V8H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS06530 ^@ http://purl.uniprot.org/uniprot/E1VB13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Membrane http://togogenome.org/gene/768066:HELO_RS15350 ^@ http://purl.uniprot.org/uniprot/E1V918 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity ^@ Belongs to the GlnD family.|||Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.|||Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity. http://togogenome.org/gene/768066:HELO_RS15490 ^@ http://purl.uniprot.org/uniprot/E1V946 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. http://togogenome.org/gene/768066:HELO_RS18950 ^@ http://purl.uniprot.org/uniprot/E1VCG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/768066:HELO_RS17860 ^@ http://purl.uniprot.org/uniprot/E1VBH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/768066:HELO_RS11040 ^@ http://purl.uniprot.org/uniprot/E1V4E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/768066:HELO_RS12175 ^@ http://purl.uniprot.org/uniprot/E1V5E2 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/768066:HELO_RS02070 ^@ http://purl.uniprot.org/uniprot/E1V6E6 ^@ Similarity ^@ Belongs to the HesB/IscA family. http://togogenome.org/gene/768066:HELO_RS01245 ^@ http://purl.uniprot.org/uniprot/E1V5K7 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||Methylated by PrmB.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/768066:HELO_RS05210 ^@ http://purl.uniprot.org/uniprot/E1V9L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsQ/DivIB family. FtsQ subfamily.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/768066:HELO_RS18215 ^@ http://purl.uniprot.org/uniprot/E1VBN8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family.