http://togogenome.org/gene/572546:ARCPR_RS05540 ^@ http://purl.uniprot.org/uniprot/D2RDG9 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/572546:ARCPR_RS09100 ^@ http://purl.uniprot.org/uniprot/D2RFH3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/572546:ARCPR_RS01365 ^@ http://purl.uniprot.org/uniprot/D2RGB9 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/572546:ARCPR_RS06240 ^@ http://purl.uniprot.org/uniprot/D2RDV2 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/572546:ARCPR_RS02115 ^@ http://purl.uniprot.org/uniprot/D2RGR3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS01020 ^@ http://purl.uniprot.org/uniprot/D2RG50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS06635 ^@ http://purl.uniprot.org/uniprot/D2RE26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS04635 ^@ http://purl.uniprot.org/uniprot/D2RI66 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/572546:ARCPR_RS09040 ^@ http://purl.uniprot.org/uniprot/D2RFG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00345 ^@ http://purl.uniprot.org/uniprot/D2RFS1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/572546:ARCPR_RS05025 ^@ http://purl.uniprot.org/uniprot/D2RD72 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/572546:ARCPR_RS07790 ^@ http://purl.uniprot.org/uniprot/D2RER1 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/572546:ARCPR_RS05865 ^@ http://purl.uniprot.org/uniprot/D2RDN0 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/572546:ARCPR_RS05285 ^@ http://purl.uniprot.org/uniprot/D2RDB9 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS02495 ^@ http://purl.uniprot.org/uniprot/D2RGY8 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/572546:ARCPR_RS00435 ^@ http://purl.uniprot.org/uniprot/D2RFU1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS09245 ^@ http://purl.uniprot.org/uniprot/D2RFK3 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/572546:ARCPR_RS04985 ^@ http://purl.uniprot.org/uniprot/D2RD64 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/572546:ARCPR_RS01790 ^@ http://purl.uniprot.org/uniprot/D2RGK2 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/572546:ARCPR_RS05115 ^@ http://purl.uniprot.org/uniprot/D2RD87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/572546:ARCPR_RS05880 ^@ http://purl.uniprot.org/uniprot/D2RDN2 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/572546:ARCPR_RS00470 ^@ http://purl.uniprot.org/uniprot/D2RFU4 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/572546:ARCPR_RS02955 ^@ http://purl.uniprot.org/uniprot/D2RH80 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/572546:ARCPR_RS09005 ^@ http://purl.uniprot.org/uniprot/D2RFF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01030 ^@ http://purl.uniprot.org/uniprot/D2RG52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/572546:ARCPR_RS00315 ^@ http://purl.uniprot.org/uniprot/D2RFR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS08230 ^@ http://purl.uniprot.org/uniprot/D2REZ8 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/572546:ARCPR_RS01655 ^@ http://purl.uniprot.org/uniprot/D2RGH7 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS06380 ^@ http://purl.uniprot.org/uniprot/D2RDY0 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/572546:ARCPR_RS00080 ^@ http://purl.uniprot.org/uniprot/D2RFM0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/572546:ARCPR_RS05070 ^@ http://purl.uniprot.org/uniprot/D2RD80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS06340 ^@ http://purl.uniprot.org/uniprot/D2RDX2 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS08655 ^@ http://purl.uniprot.org/uniprot/D2RF85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/572546:ARCPR_RS02575 ^@ http://purl.uniprot.org/uniprot/D2RH04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/572546:ARCPR_RS05395 ^@ http://purl.uniprot.org/uniprot/D2RDE1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS05890 ^@ http://purl.uniprot.org/uniprot/D2RDN4 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/572546:ARCPR_RS08225 ^@ http://purl.uniprot.org/uniprot/D2REZ7 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/572546:ARCPR_RS01180 ^@ http://purl.uniprot.org/uniprot/D2RG83 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/572546:ARCPR_RS09025 ^@ http://purl.uniprot.org/uniprot/D2RFF8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01335 ^@ http://purl.uniprot.org/uniprot/D2RGB3 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/572546:ARCPR_RS06580 ^@ http://purl.uniprot.org/uniprot/D2RE15 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/572546:ARCPR_RS01630 ^@ http://purl.uniprot.org/uniprot/D2RGH2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/572546:ARCPR_RS02990 ^@ http://purl.uniprot.org/uniprot/D2RH87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS08240 ^@ http://purl.uniprot.org/uniprot/D2RF00 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/572546:ARCPR_RS08220 ^@ http://purl.uniprot.org/uniprot/D2REZ6 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/572546:ARCPR_RS06715 ^@ http://purl.uniprot.org/uniprot/D2RE43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/572546:ARCPR_RS04615 ^@ http://purl.uniprot.org/uniprot/D2RI63 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/572546:ARCPR_RS07190 ^@ http://purl.uniprot.org/uniprot/D2RED8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/572546:ARCPR_RS05170 ^@ http://purl.uniprot.org/uniprot/D2RD97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/572546:ARCPR_RS05525 ^@ http://purl.uniprot.org/uniprot/D2RDG6 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/572546:ARCPR_RS03255 ^@ http://purl.uniprot.org/uniprot/D2RHE3 ^@ Function|||Similarity ^@ Belongs to the adenylate cyclase family. DacZ subfamily.|||Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. http://togogenome.org/gene/572546:ARCPR_RS01325 ^@ http://purl.uniprot.org/uniprot/D2RGB1 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/572546:ARCPR_RS06485 ^@ http://purl.uniprot.org/uniprot/D2RDZ9 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/572546:ARCPR_RS00160 ^@ http://purl.uniprot.org/uniprot/D2RFN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS06230 ^@ http://purl.uniprot.org/uniprot/D2RDV0 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.|||Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds via a cis-phosphoenolate intermediate. http://togogenome.org/gene/572546:ARCPR_RS02985 ^@ http://purl.uniprot.org/uniprot/D2RH86 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/572546:ARCPR_RS04320 ^@ http://purl.uniprot.org/uniprot/D2RI08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/572546:ARCPR_RS01730 ^@ http://purl.uniprot.org/uniprot/D2RGJ1 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/572546:ARCPR_RS06370 ^@ http://purl.uniprot.org/uniprot/D2RDX8 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/572546:ARCPR_RS03655 ^@ http://purl.uniprot.org/uniprot/D2RHM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS03915 ^@ http://purl.uniprot.org/uniprot/D2RHS5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS03515 ^@ http://purl.uniprot.org/uniprot/D2RHJ3 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS07935 ^@ http://purl.uniprot.org/uniprot/D2RET8 ^@ Similarity ^@ Belongs to the MTD family. http://togogenome.org/gene/572546:ARCPR_RS07910 ^@ http://purl.uniprot.org/uniprot/D2RET3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS01045 ^@ http://purl.uniprot.org/uniprot/D2RG55 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/572546:ARCPR_RS02800 ^@ http://purl.uniprot.org/uniprot/D2RH49 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/572546:ARCPR_RS02175 ^@ http://purl.uniprot.org/uniprot/D2RGS6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS03805 ^@ http://purl.uniprot.org/uniprot/D2RHQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS04880 ^@ http://purl.uniprot.org/uniprot/D2RIB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/572546:ARCPR_RS08685 ^@ http://purl.uniprot.org/uniprot/D2RF91 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS03540 ^@ http://purl.uniprot.org/uniprot/D2RHJ8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/572546:ARCPR_RS07850 ^@ http://purl.uniprot.org/uniprot/D2RES2 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/572546:ARCPR_RS08305 ^@ http://purl.uniprot.org/uniprot/D2RF13 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/572546:ARCPR_RS08435 ^@ http://purl.uniprot.org/uniprot/D2RF41 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/572546:ARCPR_RS05190 ^@ http://purl.uniprot.org/uniprot/D2RDA1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/572546:ARCPR_RS06790 ^@ http://purl.uniprot.org/uniprot/D2RE58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/572546:ARCPR_RS04305 ^@ http://purl.uniprot.org/uniprot/D2RI05 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS02465 ^@ http://purl.uniprot.org/uniprot/D2RGY2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS09095 ^@ http://purl.uniprot.org/uniprot/D2RFH2 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/572546:ARCPR_RS01485 ^@ http://purl.uniprot.org/uniprot/D2RGE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS05545 ^@ http://purl.uniprot.org/uniprot/D2RDH0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/572546:ARCPR_RS09345 ^@ http://purl.uniprot.org/uniprot/D2RHY7 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/572546:ARCPR_RS02665 ^@ http://purl.uniprot.org/uniprot/D2RH22 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/572546:ARCPR_RS06785 ^@ http://purl.uniprot.org/uniprot/D2RE57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS02385 ^@ http://purl.uniprot.org/uniprot/D2RGW6 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/572546:ARCPR_RS04895 ^@ http://purl.uniprot.org/uniprot/D2RIB8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/572546:ARCPR_RS00950 ^@ http://purl.uniprot.org/uniprot/D2RG37 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/572546:ARCPR_RS01135 ^@ http://purl.uniprot.org/uniprot/D2RG74 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/572546:ARCPR_RS03630 ^@ http://purl.uniprot.org/uniprot/D2RHL6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/572546:ARCPR_RS04680 ^@ http://purl.uniprot.org/uniprot/D2RI75 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/572546:ARCPR_RS01185 ^@ http://purl.uniprot.org/uniprot/D2RG84 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS03395 ^@ http://purl.uniprot.org/uniprot/D2RHG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/572546:ARCPR_RS01100 ^@ http://purl.uniprot.org/uniprot/D2RG67 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/572546:ARCPR_RS06495 ^@ http://purl.uniprot.org/uniprot/D2RE01 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/572546:ARCPR_RS03620 ^@ http://purl.uniprot.org/uniprot/D2RHL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/572546:ARCPR_RS03030 ^@ http://purl.uniprot.org/uniprot/D2RH95 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS06940 ^@ http://purl.uniprot.org/uniprot/D2RE89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS05535 ^@ http://purl.uniprot.org/uniprot/D2RDG8 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/572546:ARCPR_RS00260 ^@ http://purl.uniprot.org/uniprot/D2RFQ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/572546:ARCPR_RS00675 ^@ http://purl.uniprot.org/uniprot/D2RFY3 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/572546:ARCPR_RS01330 ^@ http://purl.uniprot.org/uniprot/D2RGB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/572546:ARCPR_RS02740 ^@ http://purl.uniprot.org/uniprot/D2RH38 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/572546:ARCPR_RS03485 ^@ http://purl.uniprot.org/uniprot/D2RHI7 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/572546:ARCPR_RS00350 ^@ http://purl.uniprot.org/uniprot/D2RFS2 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/572546:ARCPR_RS00110 ^@ http://purl.uniprot.org/uniprot/D2RFM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/572546:ARCPR_RS06075 ^@ http://purl.uniprot.org/uniprot/D2RDS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00660 ^@ http://purl.uniprot.org/uniprot/D2RFY1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS04360 ^@ http://purl.uniprot.org/uniprot/D2RI17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS05150 ^@ http://purl.uniprot.org/uniprot/D2RD93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS01835 ^@ http://purl.uniprot.org/uniprot/D2RGL1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/572546:ARCPR_RS07840 ^@ http://purl.uniprot.org/uniprot/D2RES0 ^@ Caution|||Function|||Similarity ^@ Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS02050 ^@ http://purl.uniprot.org/uniprot/D2RGQ0 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/572546:ARCPR_RS03970 ^@ http://purl.uniprot.org/uniprot/D2RHT5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/572546:ARCPR_RS03520 ^@ http://purl.uniprot.org/uniprot/D2RHJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane http://togogenome.org/gene/572546:ARCPR_RS09645 ^@ http://purl.uniprot.org/uniprot/D2RE63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/572546:ARCPR_RS05580 ^@ http://purl.uniprot.org/uniprot/D2RDH7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. http://togogenome.org/gene/572546:ARCPR_RS09155 ^@ http://purl.uniprot.org/uniprot/D2RFI5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/572546:ARCPR_RS08090 ^@ http://purl.uniprot.org/uniprot/D2REX0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/572546:ARCPR_RS05625 ^@ http://purl.uniprot.org/uniprot/D2RDI5 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/572546:ARCPR_RS06675 ^@ http://purl.uniprot.org/uniprot/D2RE34 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/572546:ARCPR_RS07760 ^@ http://purl.uniprot.org/uniprot/P84623 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrB family.|||Cytoplasm|||Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.|||The heterodisulfide reductase is composed of three subunits; HdlA, HdlB and HdlC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase. http://togogenome.org/gene/572546:ARCPR_RS00650 ^@ http://purl.uniprot.org/uniprot/D2RFX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/572546:ARCPR_RS05180 ^@ http://purl.uniprot.org/uniprot/D2RD99 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/572546:ARCPR_RS04960 ^@ http://purl.uniprot.org/uniprot/D2RD60 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/572546:ARCPR_RS04610 ^@ http://purl.uniprot.org/uniprot/D2RI62 ^@ Function|||Subunit ^@ Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS00215 ^@ http://purl.uniprot.org/uniprot/D2RFP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/572546:ARCPR_RS02720 ^@ http://purl.uniprot.org/uniprot/D2RH34 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/572546:ARCPR_RS02270 ^@ http://purl.uniprot.org/uniprot/D2RGU2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/572546:ARCPR_RS00360 ^@ http://purl.uniprot.org/uniprot/D2RFS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/572546:ARCPR_RS03830 ^@ http://purl.uniprot.org/uniprot/D2RHQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/572546:ARCPR_RS02935 ^@ http://purl.uniprot.org/uniprot/D2RH76 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/572546:ARCPR_RS05700 ^@ http://purl.uniprot.org/uniprot/D2RDJ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/572546:ARCPR_RS05515 ^@ http://purl.uniprot.org/uniprot/D2RDG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/572546:ARCPR_RS06300 ^@ http://purl.uniprot.org/uniprot/D2RDW4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/572546:ARCPR_RS00740 ^@ http://purl.uniprot.org/uniprot/D2RFZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/572546:ARCPR_RS01470 ^@ http://purl.uniprot.org/uniprot/D2RGD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/572546:ARCPR_RS06975 ^@ http://purl.uniprot.org/uniprot/D2RE96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/572546:ARCPR_RS05335 ^@ http://purl.uniprot.org/uniprot/D2RDC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS06400 ^@ http://purl.uniprot.org/uniprot/D2RDY4 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/572546:ARCPR_RS00265 ^@ http://purl.uniprot.org/uniprot/D2RFQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS07150 ^@ http://purl.uniprot.org/uniprot/D2RED1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS02975 ^@ http://purl.uniprot.org/uniprot/D2RH84 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/572546:ARCPR_RS01060 ^@ http://purl.uniprot.org/uniprot/D2RG58 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00255 ^@ http://purl.uniprot.org/uniprot/D2RFQ3 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/572546:ARCPR_RS05165 ^@ http://purl.uniprot.org/uniprot/D2RD96 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/572546:ARCPR_RS02860 ^@ http://purl.uniprot.org/uniprot/D2RH62 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-aspartate to produce beta-alanine. http://togogenome.org/gene/572546:ARCPR_RS01315 ^@ http://purl.uniprot.org/uniprot/D2RGB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS03700 ^@ http://purl.uniprot.org/uniprot/D2RHN2 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/572546:ARCPR_RS06200 ^@ http://purl.uniprot.org/uniprot/D2RDU4 ^@ Caution|||Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS06795 ^@ http://purl.uniprot.org/uniprot/D2RE59 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/572546:ARCPR_RS07815 ^@ http://purl.uniprot.org/uniprot/D2RER5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS06655 ^@ http://purl.uniprot.org/uniprot/D2RE30 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/572546:ARCPR_RS00945 ^@ http://purl.uniprot.org/uniprot/D2RG36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS00195 ^@ http://purl.uniprot.org/uniprot/D2RFP2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/572546:ARCPR_RS00430 ^@ http://purl.uniprot.org/uniprot/D2RFU0 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/572546:ARCPR_RS06600 ^@ http://purl.uniprot.org/uniprot/D2RE19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS01965 ^@ http://purl.uniprot.org/uniprot/D2RGN5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/572546:ARCPR_RS03140 ^@ http://purl.uniprot.org/uniprot/D2RHB9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/572546:ARCPR_RS06705 ^@ http://purl.uniprot.org/uniprot/D2RE41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS06255 ^@ http://purl.uniprot.org/uniprot/D2RDV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS04650 ^@ http://purl.uniprot.org/uniprot/D2RI69 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/572546:ARCPR_RS04995 ^@ http://purl.uniprot.org/uniprot/D2RD66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS03650 ^@ http://purl.uniprot.org/uniprot/D2RHM1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/572546:ARCPR_RS07130 ^@ http://purl.uniprot.org/uniprot/D2REC7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS05030 ^@ http://purl.uniprot.org/uniprot/D2RD73 ^@ Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Heterodimer of a large and a small subunit. http://togogenome.org/gene/572546:ARCPR_RS06195 ^@ http://purl.uniprot.org/uniprot/D2RDU3 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/572546:ARCPR_RS06805 ^@ http://purl.uniprot.org/uniprot/D2RE61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/572546:ARCPR_RS08200 ^@ http://purl.uniprot.org/uniprot/D2REZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS00380 ^@ http://purl.uniprot.org/uniprot/D2RFS9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS03535 ^@ http://purl.uniprot.org/uniprot/D2RHJ7 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/572546:ARCPR_RS07705 ^@ http://purl.uniprot.org/uniprot/D2REP3 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/572546:ARCPR_RS07695 ^@ http://purl.uniprot.org/uniprot/D2REP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. http://togogenome.org/gene/572546:ARCPR_RS01850 ^@ http://purl.uniprot.org/uniprot/D2RGL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched-chain polyamine synthase family.|||Cytoplasm|||Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. http://togogenome.org/gene/572546:ARCPR_RS06690 ^@ http://purl.uniprot.org/uniprot/D2RE37 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/572546:ARCPR_RS01930 ^@ http://purl.uniprot.org/uniprot/D2RGM8 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/572546:ARCPR_RS04990 ^@ http://purl.uniprot.org/uniprot/D2RD65 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS03980 ^@ http://purl.uniprot.org/uniprot/D2RHT7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/572546:ARCPR_RS05055 ^@ http://purl.uniprot.org/uniprot/D2RD78 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/572546:ARCPR_RS01460 ^@ http://purl.uniprot.org/uniprot/D2RGD7 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/572546:ARCPR_RS00340 ^@ http://purl.uniprot.org/uniprot/D2RFS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/572546:ARCPR_RS01810 ^@ http://purl.uniprot.org/uniprot/D2RGK6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS03235 ^@ http://purl.uniprot.org/uniprot/D2RHD9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/572546:ARCPR_RS07380 ^@ http://purl.uniprot.org/uniprot/D2REH5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/572546:ARCPR_RS06210 ^@ http://purl.uniprot.org/uniprot/D2RDU6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/572546:ARCPR_RS04875 ^@ http://purl.uniprot.org/uniprot/D2RIB4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/572546:ARCPR_RS06470 ^@ http://purl.uniprot.org/uniprot/D2RDZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS07320 ^@ http://purl.uniprot.org/uniprot/D2REG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00750 ^@ http://purl.uniprot.org/uniprot/D2RFZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS07955 ^@ http://purl.uniprot.org/uniprot/D2REU2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS07285 ^@ http://purl.uniprot.org/uniprot/D2REF7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS08680 ^@ http://purl.uniprot.org/uniprot/D2RF90 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/572546:ARCPR_RS00940 ^@ http://purl.uniprot.org/uniprot/D2RG35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS04035 ^@ http://purl.uniprot.org/uniprot/D2RHU8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/572546:ARCPR_RS02660 ^@ http://purl.uniprot.org/uniprot/D2RH21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS02325 ^@ http://purl.uniprot.org/uniprot/D2RGV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS01915 ^@ http://purl.uniprot.org/uniprot/D2RGM5 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/572546:ARCPR_RS05225 ^@ http://purl.uniprot.org/uniprot/D2RDA8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/572546:ARCPR_RS04925 ^@ http://purl.uniprot.org/uniprot/D2RIC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/572546:ARCPR_RS00785 ^@ http://purl.uniprot.org/uniprot/D2RG04 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/572546:ARCPR_RS08675 ^@ http://purl.uniprot.org/uniprot/D2RF89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/572546:ARCPR_RS03260 ^@ http://purl.uniprot.org/uniprot/D2RHE4 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/572546:ARCPR_RS03995 ^@ http://purl.uniprot.org/uniprot/D2RHU0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS03300 ^@ http://purl.uniprot.org/uniprot/D2RHF2 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/572546:ARCPR_RS06285 ^@ http://purl.uniprot.org/uniprot/D2RDW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/572546:ARCPR_RS05275 ^@ http://purl.uniprot.org/uniprot/D2RDB7 ^@ Function|||Similarity ^@ Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.|||Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.|||In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.|||In the N-terminal section; belongs to the formaldehyde-activating enzyme family. http://togogenome.org/gene/572546:ARCPR_RS05365 ^@ http://purl.uniprot.org/uniprot/D2RDD5 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/572546:ARCPR_RS07990 ^@ http://purl.uniprot.org/uniprot/D2REU9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/572546:ARCPR_RS02735 ^@ http://purl.uniprot.org/uniprot/D2RH37 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/572546:ARCPR_RS04345 ^@ http://purl.uniprot.org/uniprot/D2RI14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/572546:ARCPR_RS09640 ^@ http://purl.uniprot.org/uniprot/D2RE62 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/572546:ARCPR_RS04965 ^@ http://purl.uniprot.org/uniprot/D2RD61 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/572546:ARCPR_RS02535 ^@ http://purl.uniprot.org/uniprot/D2RGZ6 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. RfcS subfamily. http://togogenome.org/gene/572546:ARCPR_RS07180 ^@ http://purl.uniprot.org/uniprot/D2RED6 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/572546:ARCPR_RS09220 ^@ http://purl.uniprot.org/uniprot/D2RFJ8 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/572546:ARCPR_RS01410 ^@ http://purl.uniprot.org/uniprot/D2RGC7 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS04790 ^@ http://purl.uniprot.org/uniprot/D2RI96 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS01015 ^@ http://purl.uniprot.org/uniprot/D2RG49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00420 ^@ http://purl.uniprot.org/uniprot/D2RFT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS00150 ^@ http://purl.uniprot.org/uniprot/D2RFN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/572546:ARCPR_RS05605 ^@ http://purl.uniprot.org/uniprot/D2RDI1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/572546:ARCPR_RS08535 ^@ http://purl.uniprot.org/uniprot/D2RF60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/572546:ARCPR_RS08635 ^@ http://purl.uniprot.org/uniprot/P84622 ^@ Cofactor|||Function|||Subcellular Location Annotation ^@ Binds 2 [4Fe-4S] clusters per subunit.|||Has menaquinol-oxidizing activity. The HmeC and HmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS07350 ^@ http://purl.uniprot.org/uniprot/D2REH0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/572546:ARCPR_RS09050 ^@ http://purl.uniprot.org/uniprot/D2RFG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/572546:ARCPR_RS06445 ^@ http://purl.uniprot.org/uniprot/D2RDZ1 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/572546:ARCPR_RS00100 ^@ http://purl.uniprot.org/uniprot/D2RFM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/572546:ARCPR_RS00015 ^@ http://purl.uniprot.org/uniprot/D2RFK6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/572546:ARCPR_RS03690 ^@ http://purl.uniprot.org/uniprot/D2RHN0 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/572546:ARCPR_RS01755 ^@ http://purl.uniprot.org/uniprot/D2RGJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS08625 ^@ http://purl.uniprot.org/uniprot/D2RF79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS04000 ^@ http://purl.uniprot.org/uniprot/D2RHU1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/572546:ARCPR_RS01070 ^@ http://purl.uniprot.org/uniprot/D2RG60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS05045 ^@ http://purl.uniprot.org/uniprot/D2RD76 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/572546:ARCPR_RS05485 ^@ http://purl.uniprot.org/uniprot/D2RDF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/572546:ARCPR_RS01740 ^@ http://purl.uniprot.org/uniprot/D2RGJ2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS08610 ^@ http://purl.uniprot.org/uniprot/D2RF76 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/572546:ARCPR_RS01145 ^@ http://purl.uniprot.org/uniprot/D2RG76 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/572546:ARCPR_RS00815 ^@ http://purl.uniprot.org/uniprot/D2RG10 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS08560 ^@ http://purl.uniprot.org/uniprot/D2RF65 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/572546:ARCPR_RS06760 ^@ http://purl.uniprot.org/uniprot/D2RE52 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS06290 ^@ http://purl.uniprot.org/uniprot/D2RDW2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/572546:ARCPR_RS02180 ^@ http://purl.uniprot.org/uniprot/D2RGS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS07820 ^@ http://purl.uniprot.org/uniprot/D2RER6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS04055 ^@ http://purl.uniprot.org/uniprot/D2RHV2 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/572546:ARCPR_RS02965 ^@ http://purl.uniprot.org/uniprot/D2RH82 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/572546:ARCPR_RS01285 ^@ http://purl.uniprot.org/uniprot/D2RGA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS07200 ^@ http://purl.uniprot.org/uniprot/D2REE0 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. http://togogenome.org/gene/572546:ARCPR_RS04795 ^@ http://purl.uniprot.org/uniprot/D2RI97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS06800 ^@ http://purl.uniprot.org/uniprot/D2RE60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS01555 ^@ http://purl.uniprot.org/uniprot/D2RGF6 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/572546:ARCPR_RS04585 ^@ http://purl.uniprot.org/uniprot/D2RI57 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/572546:ARCPR_RS05480 ^@ http://purl.uniprot.org/uniprot/D2RDF7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/572546:ARCPR_RS03180 ^@ http://purl.uniprot.org/uniprot/D2RHC7 ^@ Similarity ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. http://togogenome.org/gene/572546:ARCPR_RS07995 ^@ http://purl.uniprot.org/uniprot/D2REV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS05570 ^@ http://purl.uniprot.org/uniprot/D2RDH5 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/572546:ARCPR_RS02570 ^@ http://purl.uniprot.org/uniprot/D2RH03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS04070 ^@ http://purl.uniprot.org/uniprot/D2RHV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/572546:ARCPR_RS06745 ^@ http://purl.uniprot.org/uniprot/D2RE49 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/572546:ARCPR_RS05835 ^@ http://purl.uniprot.org/uniprot/D2RDM5 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/572546:ARCPR_RS03560 ^@ http://purl.uniprot.org/uniprot/D2RHK2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/572546:ARCPR_RS05420 ^@ http://purl.uniprot.org/uniprot/D2RDE6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/572546:ARCPR_RS01405 ^@ http://purl.uniprot.org/uniprot/D2RGC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/572546:ARCPR_RS02015 ^@ http://purl.uniprot.org/uniprot/D2RGP3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/572546:ARCPR_RS07745 ^@ http://purl.uniprot.org/uniprot/P84625 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.|||Cytoplasm|||Part of a complex that provides reducing equivalents for heterodisulfide reductase.|||The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (Hdr). http://togogenome.org/gene/572546:ARCPR_RS02650 ^@ http://purl.uniprot.org/uniprot/D2RH19 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/572546:ARCPR_RS01085 ^@ http://purl.uniprot.org/uniprot/D2RG63 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/572546:ARCPR_RS04955 ^@ http://purl.uniprot.org/uniprot/D2RD59 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS00465 ^@ http://purl.uniprot.org/uniprot/D2RFU3 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/572546:ARCPR_RS07050 ^@ http://purl.uniprot.org/uniprot/D2REB1 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. http://togogenome.org/gene/572546:ARCPR_RS06035 ^@ http://purl.uniprot.org/uniprot/D2RDR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS04605 ^@ http://purl.uniprot.org/uniprot/D2RI61 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS07865 ^@ http://purl.uniprot.org/uniprot/D2RES5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS04755 ^@ http://purl.uniprot.org/uniprot/D2RI89 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/572546:ARCPR_RS02130 ^@ http://purl.uniprot.org/uniprot/D2RGR7 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/572546:ARCPR_RS01125 ^@ http://purl.uniprot.org/uniprot/D2RG72 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/572546:ARCPR_RS01150 ^@ http://purl.uniprot.org/uniprot/D2RG77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/572546:ARCPR_RS06415 ^@ http://purl.uniprot.org/uniprot/D2RDY6 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/572546:ARCPR_RS07085 ^@ http://purl.uniprot.org/uniprot/D2REB8 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/572546:ARCPR_RS07140 ^@ http://purl.uniprot.org/uniprot/D2REC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS07730 ^@ http://purl.uniprot.org/uniprot/D2REP9 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/572546:ARCPR_RS09110 ^@ http://purl.uniprot.org/uniprot/D2RFH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/572546:ARCPR_RS02065 ^@ http://purl.uniprot.org/uniprot/D2RGQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS02895 ^@ http://purl.uniprot.org/uniprot/D2RH68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS06480 ^@ http://purl.uniprot.org/uniprot/D2RDZ8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/572546:ARCPR_RS05145 ^@ http://purl.uniprot.org/uniprot/D2RD92 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/572546:ARCPR_RS01025 ^@ http://purl.uniprot.org/uniprot/D2RG51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/572546:ARCPR_RS00165 ^@ http://purl.uniprot.org/uniprot/D2RFN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS06475 ^@ http://purl.uniprot.org/uniprot/D2RDZ7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofG family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/572546:ARCPR_RS00290 ^@ http://purl.uniprot.org/uniprot/D2RFR0 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/572546:ARCPR_RS00800 ^@ http://purl.uniprot.org/uniprot/D2RG07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/572546:ARCPR_RS03820 ^@ http://purl.uniprot.org/uniprot/D2RHQ6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/572546:ARCPR_RS03735 ^@ http://purl.uniprot.org/uniprot/D2RHN9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/572546:ARCPR_RS06085 ^@ http://purl.uniprot.org/uniprot/D2RDS3 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/572546:ARCPR_RS06530 ^@ http://purl.uniprot.org/uniprot/D2RE08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/572546:ARCPR_RS07030 ^@ http://purl.uniprot.org/uniprot/D2REA7 ^@ Similarity ^@ Belongs to the eukaryotic RecA-like protein family. http://togogenome.org/gene/572546:ARCPR_RS08645 ^@ http://purl.uniprot.org/uniprot/D2RF83 ^@ Similarity ^@ Belongs to the tRNA(His) guanylyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS00475 ^@ http://purl.uniprot.org/uniprot/D2RFU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/572546:ARCPR_RS09085 ^@ http://purl.uniprot.org/uniprot/D2RFH0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/572546:ARCPR_RS05035 ^@ http://purl.uniprot.org/uniprot/D2RD74 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS08670 ^@ http://purl.uniprot.org/uniprot/D2RF88 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/572546:ARCPR_RS01550 ^@ http://purl.uniprot.org/uniprot/D2RGF5 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/572546:ARCPR_RS00645 ^@ http://purl.uniprot.org/uniprot/D2RFX8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/572546:ARCPR_RS06630 ^@ http://purl.uniprot.org/uniprot/D2RE25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS03935 ^@ http://purl.uniprot.org/uniprot/D2RHS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS01175 ^@ http://purl.uniprot.org/uniprot/D2RG82 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/572546:ARCPR_RS02555 ^@ http://purl.uniprot.org/uniprot/D2RH00 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/572546:ARCPR_RS02480 ^@ http://purl.uniprot.org/uniprot/D2RGY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/572546:ARCPR_RS03595 ^@ http://purl.uniprot.org/uniprot/D2RHK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS02525 ^@ http://purl.uniprot.org/uniprot/D2RGZ4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/572546:ARCPR_RS02970 ^@ http://purl.uniprot.org/uniprot/D2RH83 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS06510 ^@ http://purl.uniprot.org/uniprot/D2RE04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS05320 ^@ http://purl.uniprot.org/uniprot/D2RDC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/572546:ARCPR_RS03295 ^@ http://purl.uniprot.org/uniprot/D2RHF1 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/572546:ARCPR_RS02635 ^@ http://purl.uniprot.org/uniprot/D2RH16 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS03625 ^@ http://purl.uniprot.org/uniprot/D2RHL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS03860 ^@ http://purl.uniprot.org/uniprot/D2RHR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/572546:ARCPR_RS07280 ^@ http://purl.uniprot.org/uniprot/D2REF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS06135 ^@ http://purl.uniprot.org/uniprot/D2RDT4 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/572546:ARCPR_RS03840 ^@ http://purl.uniprot.org/uniprot/D2RHR0 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS01900 ^@ http://purl.uniprot.org/uniprot/D2RGM2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS07295 ^@ http://purl.uniprot.org/uniprot/D2REF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS05720 ^@ http://purl.uniprot.org/uniprot/D2RDK3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/572546:ARCPR_RS08210 ^@ http://purl.uniprot.org/uniprot/D2REZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS04335 ^@ http://purl.uniprot.org/uniprot/D2RI11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS04350 ^@ http://purl.uniprot.org/uniprot/D2RI15 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS06660 ^@ http://purl.uniprot.org/uniprot/D2RE31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS07720 ^@ http://purl.uniprot.org/uniprot/D2REP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS03780 ^@ http://purl.uniprot.org/uniprot/D2RHP8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/572546:ARCPR_RS06140 ^@ http://purl.uniprot.org/uniprot/D2RDT5 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/572546:ARCPR_RS00775 ^@ http://purl.uniprot.org/uniprot/D2RG02 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/572546:ARCPR_RS07385 ^@ http://purl.uniprot.org/uniprot/D2REH6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/572546:ARCPR_RS01540 ^@ http://purl.uniprot.org/uniprot/D2RGF3 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/572546:ARCPR_RS06395 ^@ http://purl.uniprot.org/uniprot/D2RDY3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS03010 ^@ http://purl.uniprot.org/uniprot/D2RH91 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/572546:ARCPR_RS01695 ^@ http://purl.uniprot.org/uniprot/D2RGI4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/572546:ARCPR_RS01415 ^@ http://purl.uniprot.org/uniprot/D2RGC8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/572546:ARCPR_RS01395 ^@ http://purl.uniprot.org/uniprot/D2RGC4 ^@ Caution|||Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00735 ^@ http://purl.uniprot.org/uniprot/D2RFZ5 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/572546:ARCPR_RS00425 ^@ http://purl.uniprot.org/uniprot/D2RFT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS00850 ^@ http://purl.uniprot.org/uniprot/D2RG17 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/572546:ARCPR_RS04060 ^@ http://purl.uniprot.org/uniprot/D2RHV3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/572546:ARCPR_RS08185 ^@ http://purl.uniprot.org/uniprot/D2REY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS04675 ^@ http://purl.uniprot.org/uniprot/D2RI74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/572546:ARCPR_RS06270 ^@ http://purl.uniprot.org/uniprot/D2RDV8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/572546:ARCPR_RS01940 ^@ http://purl.uniprot.org/uniprot/D2RGN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS09960 ^@ http://purl.uniprot.org/uniprot/D2RGN9 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/572546:ARCPR_RS00065 ^@ http://purl.uniprot.org/uniprot/D2RFL7 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/572546:ARCPR_RS04950 ^@ http://purl.uniprot.org/uniprot/D2RD58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/572546:ARCPR_RS07795 ^@ http://purl.uniprot.org/uniprot/D2RER2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/572546:ARCPR_RS03710 ^@ http://purl.uniprot.org/uniprot/D2RHN4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS07685 ^@ http://purl.uniprot.org/uniprot/D2REN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS08840 ^@ http://purl.uniprot.org/uniprot/D2RFC1 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/572546:ARCPR_RS07750 ^@ http://purl.uniprot.org/uniprot/P84627 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Cytoplasm|||Part of a complex that provides reducing equivalents for heterodisulfide reductase.|||The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (Hdr). http://togogenome.org/gene/572546:ARCPR_RS01685 ^@ http://purl.uniprot.org/uniprot/D2RGI2 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/572546:ARCPR_RS01775 ^@ http://purl.uniprot.org/uniprot/D2RGJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS07305 ^@ http://purl.uniprot.org/uniprot/D2REG0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/572546:ARCPR_RS06115 ^@ http://purl.uniprot.org/uniprot/D2RDT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01820 ^@ http://purl.uniprot.org/uniprot/D2RGK8 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/572546:ARCPR_RS02490 ^@ http://purl.uniprot.org/uniprot/D2RGY7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/572546:ARCPR_RS05600 ^@ http://purl.uniprot.org/uniprot/D2RDI0 ^@ Similarity ^@ Belongs to the UPF0292 family. http://togogenome.org/gene/572546:ARCPR_RS01165 ^@ http://purl.uniprot.org/uniprot/D2RG80 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/572546:ARCPR_RS05565 ^@ http://purl.uniprot.org/uniprot/D2RDH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS04945 ^@ http://purl.uniprot.org/uniprot/D2RD57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS04935 ^@ http://purl.uniprot.org/uniprot/D2RIC4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/572546:ARCPR_RS01605 ^@ http://purl.uniprot.org/uniprot/D2RGG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS02000 ^@ http://purl.uniprot.org/uniprot/D2RGP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/572546:ARCPR_RS01240 ^@ http://purl.uniprot.org/uniprot/D2RG94 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/572546:ARCPR_RS03440 ^@ http://purl.uniprot.org/uniprot/D2RHH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS05020 ^@ http://purl.uniprot.org/uniprot/D2RD71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HupC/HyaC/HydC family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS02900 ^@ http://purl.uniprot.org/uniprot/D2RH69 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/572546:ARCPR_RS07965 ^@ http://purl.uniprot.org/uniprot/D2REU4 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/572546:ARCPR_RS08280 ^@ http://purl.uniprot.org/uniprot/D2RF08 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/572546:ARCPR_RS08145 ^@ http://purl.uniprot.org/uniprot/D2REY1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/572546:ARCPR_RS07725 ^@ http://purl.uniprot.org/uniprot/D2REP8 ^@ Similarity ^@ Belongs to the prephenate/arogenate dehydrogenase family. http://togogenome.org/gene/572546:ARCPR_RS08235 ^@ http://purl.uniprot.org/uniprot/D2REZ9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/572546:ARCPR_RS00205 ^@ http://purl.uniprot.org/uniprot/D2RFP4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/572546:ARCPR_RS01065 ^@ http://purl.uniprot.org/uniprot/D2RG59 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/572546:ARCPR_RS06755 ^@ http://purl.uniprot.org/uniprot/D2RE51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS01280 ^@ http://purl.uniprot.org/uniprot/D2RGA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S16 family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01160 ^@ http://purl.uniprot.org/uniprot/D2RG79 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/572546:ARCPR_RS04890 ^@ http://purl.uniprot.org/uniprot/D2RIB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/572546:ARCPR_RS06730 ^@ http://purl.uniprot.org/uniprot/D2RE46 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/572546:ARCPR_RS07135 ^@ http://purl.uniprot.org/uniprot/D2REC8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/572546:ARCPR_RS09115 ^@ http://purl.uniprot.org/uniprot/D2RFH6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS02770 ^@ http://purl.uniprot.org/uniprot/D2RH43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS08290 ^@ http://purl.uniprot.org/uniprot/D2RF10 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS06525 ^@ http://purl.uniprot.org/uniprot/D2RE07 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/572546:ARCPR_RS02240 ^@ http://purl.uniprot.org/uniprot/D2RGT8 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/572546:ARCPR_RS07805 ^@ http://purl.uniprot.org/uniprot/D2RER3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/572546:ARCPR_RS08275 ^@ http://purl.uniprot.org/uniprot/D2RF07 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/572546:ARCPR_RS10025 ^@ http://purl.uniprot.org/uniprot/D2REH1 ^@ Similarity ^@ Belongs to the NAD synthetase family. http://togogenome.org/gene/572546:ARCPR_RS03015 ^@ http://purl.uniprot.org/uniprot/D2RH92 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/572546:ARCPR_RS00715 ^@ http://purl.uniprot.org/uniprot/D2RFZ1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/572546:ARCPR_RS05240 ^@ http://purl.uniprot.org/uniprot/D2RDB0 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/572546:ARCPR_RS06515 ^@ http://purl.uniprot.org/uniprot/D2RE05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/572546:ARCPR_RS03755 ^@ http://purl.uniprot.org/uniprot/D2RHP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/572546:ARCPR_RS06725 ^@ http://purl.uniprot.org/uniprot/D2RE45 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS06735 ^@ http://purl.uniprot.org/uniprot/D2RE47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/572546:ARCPR_RS02440 ^@ http://purl.uniprot.org/uniprot/D2RGX7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS08010 ^@ http://purl.uniprot.org/uniprot/D2REV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS05155 ^@ http://purl.uniprot.org/uniprot/D2RD94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/572546:ARCPR_RS04900 ^@ http://purl.uniprot.org/uniprot/D2RIB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS02105 ^@ http://purl.uniprot.org/uniprot/D2RGR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS03185 ^@ http://purl.uniprot.org/uniprot/D2RHC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmC/CycZ/HelC family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS06575 ^@ http://purl.uniprot.org/uniprot/D2RE14 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/572546:ARCPR_RS07080 ^@ http://purl.uniprot.org/uniprot/D2REB7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnC family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/572546:ARCPR_RS05125 ^@ http://purl.uniprot.org/uniprot/D2RD88 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/572546:ARCPR_RS05110 ^@ http://purl.uniprot.org/uniprot/D2RD86 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M54 family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.|||Monomer.|||Probable zinc metalloprotease whose natural substrate is unknown. http://togogenome.org/gene/572546:ARCPR_RS03810 ^@ http://purl.uniprot.org/uniprot/D2RHQ4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||In the N-terminal section; belongs to the MobA family. http://togogenome.org/gene/572546:ARCPR_RS06440 ^@ http://purl.uniprot.org/uniprot/D2RDZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/572546:ARCPR_RS05975 ^@ http://purl.uniprot.org/uniprot/D2RDQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS06710 ^@ http://purl.uniprot.org/uniprot/D2RE42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS04405 ^@ http://purl.uniprot.org/uniprot/D2RI24 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/572546:ARCPR_RS00855 ^@ http://purl.uniprot.org/uniprot/D2RG18 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/572546:ARCPR_RS07095 ^@ http://purl.uniprot.org/uniprot/D2REC0 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS03445 ^@ http://purl.uniprot.org/uniprot/D2RHH9 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/572546:ARCPR_RS03265 ^@ http://purl.uniprot.org/uniprot/D2RHE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01585 ^@ http://purl.uniprot.org/uniprot/D2RGG3 ^@ Similarity ^@ Belongs to the UPF0216 family. http://togogenome.org/gene/572546:ARCPR_RS03005 ^@ http://purl.uniprot.org/uniprot/D2RH90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS04330 ^@ http://purl.uniprot.org/uniprot/D2RI10 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/572546:ARCPR_RS04010 ^@ http://purl.uniprot.org/uniprot/D2RHU3 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/572546:ARCPR_RS06375 ^@ http://purl.uniprot.org/uniprot/D2RDX9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/572546:ARCPR_RS04085 ^@ http://purl.uniprot.org/uniprot/D2RHV8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/572546:ARCPR_RS01720 ^@ http://purl.uniprot.org/uniprot/D2RGI9 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS06205 ^@ http://purl.uniprot.org/uniprot/D2RDU5 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/572546:ARCPR_RS01620 ^@ http://purl.uniprot.org/uniprot/D2RGH0 ^@ Similarity ^@ Belongs to the arsA ATPase family. http://togogenome.org/gene/572546:ARCPR_RS06275 ^@ http://purl.uniprot.org/uniprot/D2RDV9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/572546:ARCPR_RS09205 ^@ http://purl.uniprot.org/uniprot/D2RFJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS02405 ^@ http://purl.uniprot.org/uniprot/D2RGX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS01960 ^@ http://purl.uniprot.org/uniprot/D2RGN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS01565 ^@ http://purl.uniprot.org/uniprot/D2RGF8 ^@ Caution|||Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00500 ^@ http://purl.uniprot.org/uniprot/D2RFV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS06585 ^@ http://purl.uniprot.org/uniprot/D2RE16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.|||Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).|||Homotetramer. Interacts with SepCysS. http://togogenome.org/gene/572546:ARCPR_RS02215 ^@ http://purl.uniprot.org/uniprot/D2RGT4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/572546:ARCPR_RS07980 ^@ http://purl.uniprot.org/uniprot/D2REU7 ^@ Similarity ^@ Belongs to the UbiD family. http://togogenome.org/gene/572546:ARCPR_RS08270 ^@ http://purl.uniprot.org/uniprot/D2RF06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/572546:ARCPR_RS05135 ^@ http://purl.uniprot.org/uniprot/D2RD90 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/572546:ARCPR_RS01510 ^@ http://purl.uniprot.org/uniprot/D2RGE7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01075 ^@ http://purl.uniprot.org/uniprot/D2RG61 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS01675 ^@ http://purl.uniprot.org/uniprot/D2RGI1 ^@ Similarity ^@ Belongs to the UPF0200 family.|||Belongs to the UPF0201 family. http://togogenome.org/gene/572546:ARCPR_RS03020 ^@ http://purl.uniprot.org/uniprot/D2RH93 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/572546:ARCPR_RS07390 ^@ http://purl.uniprot.org/uniprot/D2REH7 ^@ Similarity ^@ Belongs to the MoaB/Mog family. http://togogenome.org/gene/572546:ARCPR_RS03965 ^@ http://purl.uniprot.org/uniprot/D2RHT4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. http://togogenome.org/gene/572546:ARCPR_RS05460 ^@ http://purl.uniprot.org/uniprot/D2RDF4 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/572546:ARCPR_RS00655 ^@ http://purl.uniprot.org/uniprot/D2RFY0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/572546:ARCPR_RS08615 ^@ http://purl.uniprot.org/uniprot/D2RF77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrC/TusE family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS02165 ^@ http://purl.uniprot.org/uniprot/D2RGS4 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/572546:ARCPR_RS05470 ^@ http://purl.uniprot.org/uniprot/D2RDF5 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/572546:ARCPR_RS00480 ^@ http://purl.uniprot.org/uniprot/D2RFU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS02560 ^@ http://purl.uniprot.org/uniprot/D2RH01 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/572546:ARCPR_RS05555 ^@ http://purl.uniprot.org/uniprot/D2RDH2 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/572546:ARCPR_RS06665 ^@ http://purl.uniprot.org/uniprot/D2RE32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/572546:ARCPR_RS06185 ^@ http://purl.uniprot.org/uniprot/D2RDU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/572546:ARCPR_RS07670 ^@ http://purl.uniprot.org/uniprot/D2REN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS02725 ^@ http://purl.uniprot.org/uniprot/D2RH35 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS05005 ^@ http://purl.uniprot.org/uniprot/D2RD68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS01130 ^@ http://purl.uniprot.org/uniprot/D2RG73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS01055 ^@ http://purl.uniprot.org/uniprot/D2RG57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/572546:ARCPR_RS06770 ^@ http://purl.uniprot.org/uniprot/D2RE54 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/572546:ARCPR_RS01360 ^@ http://purl.uniprot.org/uniprot/D2RGB8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/572546:ARCPR_RS06535 ^@ http://purl.uniprot.org/uniprot/D2RE09 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/572546:ARCPR_RS00960 ^@ http://purl.uniprot.org/uniprot/D2RG38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS03230 ^@ http://purl.uniprot.org/uniprot/D2RHD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS02485 ^@ http://purl.uniprot.org/uniprot/D2RGY6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/572546:ARCPR_RS02550 ^@ http://purl.uniprot.org/uniprot/D2RGZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/572546:ARCPR_RS05520 ^@ http://purl.uniprot.org/uniprot/D2RDG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/572546:ARCPR_RS02075 ^@ http://purl.uniprot.org/uniprot/D2RGQ5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS07325 ^@ http://purl.uniprot.org/uniprot/D2REG4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS07765 ^@ http://purl.uniprot.org/uniprot/P84621 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrC family.|||Cytoplasm|||Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.|||The heterodisulfide reductase is composed of three subunits; HdlA, HdlB and HdlC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase. http://togogenome.org/gene/572546:ARCPR_RS08480 ^@ http://purl.uniprot.org/uniprot/D2RF51 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/572546:ARCPR_RS00005 ^@ http://purl.uniprot.org/uniprot/D2RFK4 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/572546:ARCPR_RS02095 ^@ http://purl.uniprot.org/uniprot/D2RGQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS06145 ^@ http://purl.uniprot.org/uniprot/D2RDT6 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/572546:ARCPR_RS07265 ^@ http://purl.uniprot.org/uniprot/D2REF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/572546:ARCPR_RS06100 ^@ http://purl.uniprot.org/uniprot/D2RDS6 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/572546:ARCPR_RS04625 ^@ http://purl.uniprot.org/uniprot/D2RI64 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/572546:ARCPR_RS04850 ^@ http://purl.uniprot.org/uniprot/D2RIB0 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/572546:ARCPR_RS03245 ^@ http://purl.uniprot.org/uniprot/D2RHE1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/572546:ARCPR_RS06825 ^@ http://purl.uniprot.org/uniprot/D2RE65 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS05400 ^@ http://purl.uniprot.org/uniprot/D2RDE2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/572546:ARCPR_RS06830 ^@ http://purl.uniprot.org/uniprot/D2RE66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/572546:ARCPR_RS07340 ^@ http://purl.uniprot.org/uniprot/D2REG8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/572546:ARCPR_RS06350 ^@ http://purl.uniprot.org/uniprot/D2RDX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS08195 ^@ http://purl.uniprot.org/uniprot/D2REZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS02670 ^@ http://purl.uniprot.org/uniprot/D2RH23 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/572546:ARCPR_RS03130 ^@ http://purl.uniprot.org/uniprot/D2RHB7 ^@ Function|||Similarity ^@ Belongs to the type-2 OGG1 family.|||Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). http://togogenome.org/gene/572546:ARCPR_RS07300 ^@ http://purl.uniprot.org/uniprot/D2REF9 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/572546:ARCPR_RS01595 ^@ http://purl.uniprot.org/uniprot/D2RGG5 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/572546:ARCPR_RS03290 ^@ http://purl.uniprot.org/uniprot/D2RHF0 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS02045 ^@ http://purl.uniprot.org/uniprot/D2RGP9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CofE family.|||Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.|||Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.|||Homodimer.|||Monovalent cation. The ion could be potassium. http://togogenome.org/gene/572546:ARCPR_RS07115 ^@ http://purl.uniprot.org/uniprot/D2REC4 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/572546:ARCPR_RS06740 ^@ http://purl.uniprot.org/uniprot/D2RE48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS02885 ^@ http://purl.uniprot.org/uniprot/D2RH67 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/572546:ARCPR_RS02785 ^@ http://purl.uniprot.org/uniprot/D2RH46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS01905 ^@ http://purl.uniprot.org/uniprot/D2RGM3 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/572546:ARCPR_RS02220 ^@ http://purl.uniprot.org/uniprot/D2RGT5 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/572546:ARCPR_RS07270 ^@ http://purl.uniprot.org/uniprot/D2REF4 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/572546:ARCPR_RS05205 ^@ http://purl.uniprot.org/uniprot/D2RDA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS02645 ^@ http://purl.uniprot.org/uniprot/D2RH18 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/572546:ARCPR_RS01700 ^@ http://purl.uniprot.org/uniprot/D2RGI5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/572546:ARCPR_RS06775 ^@ http://purl.uniprot.org/uniprot/D2RE55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS09075 ^@ http://purl.uniprot.org/uniprot/D2RFG8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00235 ^@ http://purl.uniprot.org/uniprot/D2RFP9 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/572546:ARCPR_RS06190 ^@ http://purl.uniprot.org/uniprot/D2RDU2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/572546:ARCPR_RS00890 ^@ http://purl.uniprot.org/uniprot/D2RG25 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/572546:ARCPR_RS06685 ^@ http://purl.uniprot.org/uniprot/D2RE36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/572546:ARCPR_RS00220 ^@ http://purl.uniprot.org/uniprot/D2RFP7 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/572546:ARCPR_RS01590 ^@ http://purl.uniprot.org/uniprot/D2RGG4 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/572546:ARCPR_RS07035 ^@ http://purl.uniprot.org/uniprot/D2REA8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/572546:ARCPR_RS07255 ^@ http://purl.uniprot.org/uniprot/D2REF1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/572546:ARCPR_RS03400 ^@ http://purl.uniprot.org/uniprot/D2RHH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/572546:ARCPR_RS05295 ^@ http://purl.uniprot.org/uniprot/D2RDC1 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/572546:ARCPR_RS04865 ^@ http://purl.uniprot.org/uniprot/D2RIB2 ^@ Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Part of the RNA polymerase complex. http://togogenome.org/gene/572546:ARCPR_RS05635 ^@ http://purl.uniprot.org/uniprot/D2RDI7 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/572546:ARCPR_RS06880 ^@ http://purl.uniprot.org/uniprot/D2RE77 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/572546:ARCPR_RS08985 ^@ http://purl.uniprot.org/uniprot/D2RFF1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/572546:ARCPR_RS06225 ^@ http://purl.uniprot.org/uniprot/D2RDU9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS04370 ^@ http://purl.uniprot.org/uniprot/D2RI19 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/572546:ARCPR_RS03450 ^@ http://purl.uniprot.org/uniprot/D2RHI0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/572546:ARCPR_RS06780 ^@ http://purl.uniprot.org/uniprot/D2RE56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/572546:ARCPR_RS06345 ^@ http://purl.uniprot.org/uniprot/D2RDX3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/572546:ARCPR_RS00390 ^@ http://purl.uniprot.org/uniprot/D2RFT1 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/572546:ARCPR_RS00295 ^@ http://purl.uniprot.org/uniprot/D2RFR1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/572546:ARCPR_RS05640 ^@ http://purl.uniprot.org/uniprot/D2RDI8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS00375 ^@ http://purl.uniprot.org/uniprot/D2RFS8 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/572546:ARCPR_RS05305 ^@ http://purl.uniprot.org/uniprot/D2RDC3 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/572546:ARCPR_RS06750 ^@ http://purl.uniprot.org/uniprot/D2RE50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/572546:ARCPR_RS02145 ^@ http://purl.uniprot.org/uniprot/D2RGS0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00535 ^@ http://purl.uniprot.org/uniprot/D2RFV7 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/572546:ARCPR_RS07755 ^@ http://purl.uniprot.org/uniprot/P84624 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MvhD/VhuD family.|||Binds 1 [2Fe-2S] cluster.|||Cytoplasm|||Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site for heterodisulfide reductase.|||The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (Hdr). http://togogenome.org/gene/572546:ARCPR_RS02430 ^@ http://purl.uniprot.org/uniprot/D2RGX5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/572546:ARCPR_RS04825 ^@ http://purl.uniprot.org/uniprot/D2RIA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane http://togogenome.org/gene/572546:ARCPR_RS07105 ^@ http://purl.uniprot.org/uniprot/D2REC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CetZ family.|||Cytoplasm|||Involved in cell shape control. http://togogenome.org/gene/572546:ARCPR_RS01650 ^@ http://purl.uniprot.org/uniprot/D2RGH6 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/572546:ARCPR_RS03105 ^@ http://purl.uniprot.org/uniprot/D2RHB2 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/572546:ARCPR_RS01935 ^@ http://purl.uniprot.org/uniprot/D2RGM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/572546:ARCPR_RS02505 ^@ http://purl.uniprot.org/uniprot/D2RGZ0 ^@ Caution|||Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS09420 ^@ http://purl.uniprot.org/uniprot/D2RF11 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/572546:ARCPR_RS03160 ^@ http://purl.uniprot.org/uniprot/D2RHC3 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/572546:ARCPR_RS04885 ^@ http://purl.uniprot.org/uniprot/D2RIB6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/572546:ARCPR_RS03480 ^@ http://purl.uniprot.org/uniprot/D2RHI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/572546:ARCPR_RS08665 ^@ http://purl.uniprot.org/uniprot/D2RF87 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/572546:ARCPR_RS04905 ^@ http://purl.uniprot.org/uniprot/D2RIC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/572546:ARCPR_RS05385 ^@ http://purl.uniprot.org/uniprot/D2RDD9 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/572546:ARCPR_RS06895 ^@ http://purl.uniprot.org/uniprot/D2RE80 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/572546:ARCPR_RS04870 ^@ http://purl.uniprot.org/uniprot/D2RIB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/572546:ARCPR_RS00285 ^@ http://purl.uniprot.org/uniprot/D2RFQ9 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS05610 ^@ http://purl.uniprot.org/uniprot/D2RDI2 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/572546:ARCPR_RS00790 ^@ http://purl.uniprot.org/uniprot/D2RG05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00145 ^@ http://purl.uniprot.org/uniprot/D2RFN2 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/572546:ARCPR_RS03430 ^@ http://purl.uniprot.org/uniprot/D2RHH6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS00685 ^@ http://purl.uniprot.org/uniprot/D2RFY5 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS07970 ^@ http://purl.uniprot.org/uniprot/D2REU5 ^@ Similarity ^@ In the C-terminal section; belongs to the trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/572546:ARCPR_RS04050 ^@ http://purl.uniprot.org/uniprot/D2RHV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/572546:ARCPR_RS06245 ^@ http://purl.uniprot.org/uniprot/D2RDV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS05900 ^@ http://purl.uniprot.org/uniprot/D2RDN6 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/572546:ARCPR_RS05265 ^@ http://purl.uniprot.org/uniprot/D2RDB5 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/572546:ARCPR_RS03825 ^@ http://purl.uniprot.org/uniprot/D2RHQ7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/572546:ARCPR_RS03035 ^@ http://purl.uniprot.org/uniprot/D2RH96 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. http://togogenome.org/gene/572546:ARCPR_RS02500 ^@ http://purl.uniprot.org/uniprot/D2RGY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/572546:ARCPR_RS00795 ^@ http://purl.uniprot.org/uniprot/D2RG06 ^@ Similarity ^@ Belongs to the FTR family. http://togogenome.org/gene/572546:ARCPR_RS00830 ^@ http://purl.uniprot.org/uniprot/D2RG13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00730 ^@ http://purl.uniprot.org/uniprot/D2RFZ4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS07855 ^@ http://purl.uniprot.org/uniprot/D2RES3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS07165 ^@ http://purl.uniprot.org/uniprot/D2RED4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/572546:ARCPR_RS03960 ^@ http://purl.uniprot.org/uniprot/D2RHT3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/572546:ARCPR_RS03025 ^@ http://purl.uniprot.org/uniprot/D2RH94 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/572546:ARCPR_RS07825 ^@ http://purl.uniprot.org/uniprot/D2RER7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/572546:ARCPR_RS01600 ^@ http://purl.uniprot.org/uniprot/D2RGG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS04805 ^@ http://purl.uniprot.org/uniprot/D2RI99 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/572546:ARCPR_RS06765 ^@ http://purl.uniprot.org/uniprot/D2RE53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/572546:ARCPR_RS08660 ^@ http://purl.uniprot.org/uniprot/D2RF86 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/572546:ARCPR_RS08590 ^@ http://purl.uniprot.org/uniprot/D2RF71 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/572546:ARCPR_RS08215 ^@ http://purl.uniprot.org/uniprot/D2REZ5 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/572546:ARCPR_RS08630 ^@ http://purl.uniprot.org/uniprot/P84628 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Has menaquinol-oxidizing activity. The HmeC and HmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane. http://togogenome.org/gene/572546:ARCPR_RS06700 ^@ http://purl.uniprot.org/uniprot/D2RE39 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/572546:ARCPR_RS09045 ^@ http://purl.uniprot.org/uniprot/D2RFG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00925 ^@ http://purl.uniprot.org/uniprot/D2RG32 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/572546:ARCPR_RS03415 ^@ http://purl.uniprot.org/uniprot/D2RHH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS03305 ^@ http://purl.uniprot.org/uniprot/D2RHF3 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class II subfamily.|||Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/572546:ARCPR_RS06720 ^@ http://purl.uniprot.org/uniprot/D2RE44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/572546:ARCPR_RS03790 ^@ http://purl.uniprot.org/uniprot/D2RHQ0 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/572546:ARCPR_RS02630 ^@ http://purl.uniprot.org/uniprot/D2RH15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS05910 ^@ http://purl.uniprot.org/uniprot/D2RDN8 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/572546:ARCPR_RS03950 ^@ http://purl.uniprot.org/uniprot/D2RHT2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/572546:ARCPR_RS07810 ^@ http://purl.uniprot.org/uniprot/D2RER4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/572546:ARCPR_RS05105 ^@ http://purl.uniprot.org/uniprot/D2RD85 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/572546:ARCPR_RS00400 ^@ http://purl.uniprot.org/uniprot/D2RFT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS05140 ^@ http://purl.uniprot.org/uniprot/D2RD91 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/572546:ARCPR_RS02350 ^@ http://purl.uniprot.org/uniprot/D2RGV8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/572546:ARCPR_RS02090 ^@ http://purl.uniprot.org/uniprot/D2RGQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system.|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/572546:ARCPR_RS02355 ^@ http://purl.uniprot.org/uniprot/D2RGV9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/572546:ARCPR_RS07885 ^@ http://purl.uniprot.org/uniprot/D2RES9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/572546:ARCPR_RS00175 ^@ http://purl.uniprot.org/uniprot/D2RFN8 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/572546:ARCPR_RS03680 ^@ http://purl.uniprot.org/uniprot/D2RHM8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/572546:ARCPR_RS07770 ^@ http://purl.uniprot.org/uniprot/P84626 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrA family.|||Binds 4 [4Fe-4S] clusters per subunit.|||Cytoplasm|||Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.|||The heterodisulfide reductase is composed of three subunits; HdlA, HdlB and HdlC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase. http://togogenome.org/gene/572546:ARCPR_RS04640 ^@ http://purl.uniprot.org/uniprot/D2RI67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/572546:ARCPR_RS00865 ^@ http://purl.uniprot.org/uniprot/D2RG20 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/572546:ARCPR_RS05410 ^@ http://purl.uniprot.org/uniprot/D2RDE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/572546:ARCPR_RS00030 ^@ http://purl.uniprot.org/uniprot/D2RFK9 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/572546:ARCPR_RS08975 ^@ http://purl.uniprot.org/uniprot/D2RFE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/572546:ARCPR_RS01385 ^@ http://purl.uniprot.org/uniprot/D2RGC3 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/572546:ARCPR_RS01445 ^@ http://purl.uniprot.org/uniprot/D2RGD4 ^@ Similarity ^@ Belongs to the UPF0280 family. http://togogenome.org/gene/572546:ARCPR_RS00275 ^@ http://purl.uniprot.org/uniprot/D2RFQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/572546:ARCPR_RS04845 ^@ http://purl.uniprot.org/uniprot/D2RIA9 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/572546:ARCPR_RS00900 ^@ http://purl.uniprot.org/uniprot/D2RG27 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/572546:ARCPR_RS03205 ^@ http://purl.uniprot.org/uniprot/D2RHD3 ^@ Similarity ^@ Belongs to the TlyA family.