http://togogenome.org/gene/445932:EMIN_RS03690 ^@ http://purl.uniprot.org/uniprot/B2KCM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS07130 ^@ http://purl.uniprot.org/uniprot/B2KEK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/445932:EMIN_RS02990 ^@ http://purl.uniprot.org/uniprot/B2KC06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial secretin family.|||Cell outer membrane http://togogenome.org/gene/445932:EMIN_RS06640 ^@ http://purl.uniprot.org/uniprot/B2KEA9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/445932:EMIN_RS03250 ^@ http://purl.uniprot.org/uniprot/B2KC58 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/445932:EMIN_RS02080 ^@ http://purl.uniprot.org/uniprot/B2KBE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05690 ^@ http://purl.uniprot.org/uniprot/B2KDS3 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/445932:EMIN_RS00615 ^@ http://purl.uniprot.org/uniprot/B2KAZ0 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/445932:EMIN_RS00010 ^@ http://purl.uniprot.org/uniprot/B2KAM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/445932:EMIN_RS02735 ^@ http://purl.uniprot.org/uniprot/B2KCG1 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/445932:EMIN_RS05210 ^@ http://purl.uniprot.org/uniprot/B2KDH6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/445932:EMIN_RS00270 ^@ http://purl.uniprot.org/uniprot/B2KAS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS05250 ^@ http://purl.uniprot.org/uniprot/B2KDI4 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/445932:EMIN_RS07260 ^@ http://purl.uniprot.org/uniprot/B2KEN2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/445932:EMIN_RS06345 ^@ http://purl.uniprot.org/uniprot/B2KE50 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/445932:EMIN_RS07715 ^@ http://purl.uniprot.org/uniprot/B2KEW3 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS06950 ^@ http://purl.uniprot.org/uniprot/B2KEG9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/445932:EMIN_RS07820 ^@ http://purl.uniprot.org/uniprot/B2KEY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS05765 ^@ http://purl.uniprot.org/uniprot/B2KDT8 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/445932:EMIN_RS05795 ^@ http://purl.uniprot.org/uniprot/B2KDU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS01455 ^@ http://purl.uniprot.org/uniprot/B2KBU4 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/445932:EMIN_RS03635 ^@ http://purl.uniprot.org/uniprot/B2KCL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/445932:EMIN_RS06490 ^@ http://purl.uniprot.org/uniprot/B2KE79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06900 ^@ http://purl.uniprot.org/uniprot/B2KEF9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/445932:EMIN_RS00715 ^@ http://purl.uniprot.org/uniprot/B2KBL7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/445932:EMIN_RS05190 ^@ http://purl.uniprot.org/uniprot/B2KDH2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS01055 ^@ http://purl.uniprot.org/uniprot/B2KB10 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/445932:EMIN_RS05550 ^@ http://purl.uniprot.org/uniprot/B2KDP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06300 ^@ http://purl.uniprot.org/uniprot/B2KE42 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/445932:EMIN_RS00170 ^@ http://purl.uniprot.org/uniprot/B2KAQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/445932:EMIN_RS01845 ^@ http://purl.uniprot.org/uniprot/B2KB97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS08215 ^@ http://purl.uniprot.org/uniprot/B2KCK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS06705 ^@ http://purl.uniprot.org/uniprot/B2KEC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/445932:EMIN_RS03820 ^@ http://purl.uniprot.org/uniprot/B2KCP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/445932:EMIN_RS06365 ^@ http://purl.uniprot.org/uniprot/B2KE54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). http://togogenome.org/gene/445932:EMIN_RS04025 ^@ http://purl.uniprot.org/uniprot/B2KCU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS07190 ^@ http://purl.uniprot.org/uniprot/B2KEL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/445932:EMIN_RS03365 ^@ http://purl.uniprot.org/uniprot/B2KC80 ^@ Similarity ^@ Belongs to the NAD synthetase family. http://togogenome.org/gene/445932:EMIN_RS03895 ^@ http://purl.uniprot.org/uniprot/B2KCR4 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS00670 ^@ http://purl.uniprot.org/uniprot/B2KB01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/445932:EMIN_RS02890 ^@ http://purl.uniprot.org/uniprot/B2KCJ2 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/445932:EMIN_RS07155 ^@ http://purl.uniprot.org/uniprot/B2KEL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/445932:EMIN_RS06910 ^@ http://purl.uniprot.org/uniprot/B2KEG1 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS04340 ^@ http://purl.uniprot.org/uniprot/B2KD05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell inner membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity. http://togogenome.org/gene/445932:EMIN_RS00350 ^@ http://purl.uniprot.org/uniprot/B2KAU0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/445932:EMIN_RS02165 ^@ http://purl.uniprot.org/uniprot/B2KBF5 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/445932:EMIN_RS06070 ^@ http://purl.uniprot.org/uniprot/B2KDZ6 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/445932:EMIN_RS04650 ^@ http://purl.uniprot.org/uniprot/B2KD63 ^@ Similarity ^@ Belongs to the CTP synthase family. http://togogenome.org/gene/445932:EMIN_RS03395 ^@ http://purl.uniprot.org/uniprot/B2KC86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/445932:EMIN_RS08430 ^@ http://purl.uniprot.org/uniprot/B2KE99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS00220 ^@ http://purl.uniprot.org/uniprot/B2KAR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS01195 ^@ http://purl.uniprot.org/uniprot/B2KB39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Cell inner membrane|||Cell membrane|||Membrane|||Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine. http://togogenome.org/gene/445932:EMIN_RS06860 ^@ http://purl.uniprot.org/uniprot/B2KEF1 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/445932:EMIN_RS05405 ^@ http://purl.uniprot.org/uniprot/B2KDL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06720 ^@ http://purl.uniprot.org/uniprot/B2KEC5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/445932:EMIN_RS02725 ^@ http://purl.uniprot.org/uniprot/B2KCF9 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/445932:EMIN_RS00295 ^@ http://purl.uniprot.org/uniprot/B2KAS9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS00665 ^@ http://purl.uniprot.org/uniprot/B2KB00 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/445932:EMIN_RS05970 ^@ http://purl.uniprot.org/uniprot/B2KDX7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/445932:EMIN_RS03140 ^@ http://purl.uniprot.org/uniprot/B2KC37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS02670 ^@ http://purl.uniprot.org/uniprot/B2KCE9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/445932:EMIN_RS07085 ^@ http://purl.uniprot.org/uniprot/B2KEJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/445932:EMIN_RS01985 ^@ http://purl.uniprot.org/uniprot/B2KBC2 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/445932:EMIN_RS05365 ^@ http://purl.uniprot.org/uniprot/B2KDK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06865 ^@ http://purl.uniprot.org/uniprot/B2KEF2 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS07265 ^@ http://purl.uniprot.org/uniprot/B2KEN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/445932:EMIN_RS07685 ^@ http://purl.uniprot.org/uniprot/B2KEV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS02915 ^@ http://purl.uniprot.org/uniprot/B2KBZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell inner membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/445932:EMIN_RS06730 ^@ http://purl.uniprot.org/uniprot/B2KEC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01115 ^@ http://purl.uniprot.org/uniprot/B2KB21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS00945 ^@ http://purl.uniprot.org/uniprot/B2KBR2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/445932:EMIN_RS07805 ^@ http://purl.uniprot.org/uniprot/B2KEY0 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/445932:EMIN_RS02810 ^@ http://purl.uniprot.org/uniprot/B2KCH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/445932:EMIN_RS02695 ^@ http://purl.uniprot.org/uniprot/B2KCF3 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/445932:EMIN_RS06620 ^@ http://purl.uniprot.org/uniprot/B2KEA5 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/445932:EMIN_RS00775 ^@ http://purl.uniprot.org/uniprot/B2KBM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/445932:EMIN_RS05740 ^@ http://purl.uniprot.org/uniprot/B2KDT3 ^@ Similarity ^@ Belongs to the peptidase A31 family. http://togogenome.org/gene/445932:EMIN_RS02575 ^@ http://purl.uniprot.org/uniprot/B2KCD3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS01230 ^@ http://purl.uniprot.org/uniprot/B2KB46 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated Cas9 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.|||Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.|||Monomer. Binds crRNA and tracrRNA. http://togogenome.org/gene/445932:EMIN_RS01235 ^@ http://purl.uniprot.org/uniprot/B2KB47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/445932:EMIN_RS01920 ^@ http://purl.uniprot.org/uniprot/B2KBA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/445932:EMIN_RS00420 ^@ http://purl.uniprot.org/uniprot/B2KAV3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/445932:EMIN_RS03345 ^@ http://purl.uniprot.org/uniprot/B2KC76 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/445932:EMIN_RS05570 ^@ http://purl.uniprot.org/uniprot/B2KDP8 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/445932:EMIN_RS00120 ^@ http://purl.uniprot.org/uniprot/B2KAP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/445932:EMIN_RS06920 ^@ http://purl.uniprot.org/uniprot/B2KEG3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/445932:EMIN_RS04425 ^@ http://purl.uniprot.org/uniprot/B2KD23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS00635 ^@ http://purl.uniprot.org/uniprot/B2KAZ4 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/445932:EMIN_RS00755 ^@ http://purl.uniprot.org/uniprot/B2KBM5 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS03685 ^@ http://purl.uniprot.org/uniprot/B2KCM5 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.|||In the N-terminal section; belongs to the histidinol-phosphatase family. http://togogenome.org/gene/445932:EMIN_RS02815 ^@ http://purl.uniprot.org/uniprot/B2KCH7 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/445932:EMIN_RS03645 ^@ http://purl.uniprot.org/uniprot/B2KCL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS02705 ^@ http://purl.uniprot.org/uniprot/B2KCF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS02210 ^@ http://purl.uniprot.org/uniprot/B2KBG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS04400 ^@ http://purl.uniprot.org/uniprot/B2KD18 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/445932:EMIN_RS02710 ^@ http://purl.uniprot.org/uniprot/B2KCF6 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS04305 ^@ http://purl.uniprot.org/uniprot/B2KCZ8 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/445932:EMIN_RS06290 ^@ http://purl.uniprot.org/uniprot/B2KE40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS08010 ^@ http://purl.uniprot.org/uniprot/B2KBT6 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/445932:EMIN_RS03145 ^@ http://purl.uniprot.org/uniprot/B2KC38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS04610 ^@ http://purl.uniprot.org/uniprot/B2KD56 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/445932:EMIN_RS02660 ^@ http://purl.uniprot.org/uniprot/B2KCE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01665 ^@ http://purl.uniprot.org/uniprot/B2KBY2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MlaE permease family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05805 ^@ http://purl.uniprot.org/uniprot/B2KDU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS04430 ^@ http://purl.uniprot.org/uniprot/B2KD24 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/445932:EMIN_RS04165 ^@ http://purl.uniprot.org/uniprot/B2KCW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS04110 ^@ http://purl.uniprot.org/uniprot/B2KCV8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS02015 ^@ http://purl.uniprot.org/uniprot/B2KBC8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/445932:EMIN_RS00710 ^@ http://purl.uniprot.org/uniprot/B2KBL6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/445932:EMIN_RS05545 ^@ http://purl.uniprot.org/uniprot/B2KDP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS08195 ^@ http://purl.uniprot.org/uniprot/B2KC81 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/445932:EMIN_RS03480 ^@ http://purl.uniprot.org/uniprot/B2KCA4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/445932:EMIN_RS02720 ^@ http://purl.uniprot.org/uniprot/B2KCF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/445932:EMIN_RS05750 ^@ http://purl.uniprot.org/uniprot/B2KDT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS03540 ^@ http://purl.uniprot.org/uniprot/B2KCJ6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/445932:EMIN_RS06735 ^@ http://purl.uniprot.org/uniprot/B2KEC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Slam family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS03745 ^@ http://purl.uniprot.org/uniprot/B2KCN5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/445932:EMIN_RS07895 ^@ http://purl.uniprot.org/uniprot/B2KEZ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/445932:EMIN_RS04655 ^@ http://purl.uniprot.org/uniprot/B2KD64 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/445932:EMIN_RS06195 ^@ http://purl.uniprot.org/uniprot/B2KE21 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/445932:EMIN_RS05280 ^@ http://purl.uniprot.org/uniprot/B2KDI9 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/445932:EMIN_RS07250 ^@ http://purl.uniprot.org/uniprot/B2KEN0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/445932:EMIN_RS07195 ^@ http://purl.uniprot.org/uniprot/B2KEL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/445932:EMIN_RS05455 ^@ http://purl.uniprot.org/uniprot/B2KDM5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS00200 ^@ http://purl.uniprot.org/uniprot/B2KAR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/445932:EMIN_RS00515 ^@ http://purl.uniprot.org/uniprot/B2KAX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/445932:EMIN_RS05285 ^@ http://purl.uniprot.org/uniprot/B2KDJ0 ^@ Similarity ^@ Belongs to the CarB family. http://togogenome.org/gene/445932:EMIN_RS00435 ^@ http://purl.uniprot.org/uniprot/B2KAV6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/445932:EMIN_RS06575 ^@ http://purl.uniprot.org/uniprot/B2KE96 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS04660 ^@ http://purl.uniprot.org/uniprot/B2KD65 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/445932:EMIN_RS03975 ^@ http://purl.uniprot.org/uniprot/B2KCS9 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/445932:EMIN_RS01380 ^@ http://purl.uniprot.org/uniprot/B2KBT0 ^@ Function|||Similarity ^@ Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/445932:EMIN_RS02295 ^@ http://purl.uniprot.org/uniprot/B2KBH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07465 ^@ http://purl.uniprot.org/uniprot/B2KER6 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/445932:EMIN_RS06020 ^@ http://purl.uniprot.org/uniprot/B2KDY7 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/445932:EMIN_RS07635 ^@ http://purl.uniprot.org/uniprot/B2KEU9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/445932:EMIN_RS08075 ^@ http://purl.uniprot.org/uniprot/B2KBE4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/445932:EMIN_RS06510 ^@ http://purl.uniprot.org/uniprot/B2KE83 ^@ Subcellular Location Annotation ^@ Periplasm http://togogenome.org/gene/445932:EMIN_RS06745 ^@ http://purl.uniprot.org/uniprot/B2KED0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell inner membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/445932:EMIN_RS01660 ^@ http://purl.uniprot.org/uniprot/B2KBY1 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/445932:EMIN_RS03405 ^@ http://purl.uniprot.org/uniprot/B2KC88 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS00875 ^@ http://purl.uniprot.org/uniprot/B2KBP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07230 ^@ http://purl.uniprot.org/uniprot/B2KEM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/445932:EMIN_RS03550 ^@ http://purl.uniprot.org/uniprot/B2KCJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05630 ^@ http://purl.uniprot.org/uniprot/B2KDR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS01805 ^@ http://purl.uniprot.org/uniprot/B2KB90 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/445932:EMIN_RS06410 ^@ http://purl.uniprot.org/uniprot/B2KE63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/445932:EMIN_RS04675 ^@ http://purl.uniprot.org/uniprot/B2KD68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05785 ^@ http://purl.uniprot.org/uniprot/B2KDU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05920 ^@ http://purl.uniprot.org/uniprot/B2KDW8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/445932:EMIN_RS07875 ^@ http://purl.uniprot.org/uniprot/B2KEZ3 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/445932:EMIN_RS00940 ^@ http://purl.uniprot.org/uniprot/B2KBR1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/445932:EMIN_RS07065 ^@ http://purl.uniprot.org/uniprot/B2KEJ2 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/445932:EMIN_RS03660 ^@ http://purl.uniprot.org/uniprot/B2KCM0 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/445932:EMIN_RS01935 ^@ http://purl.uniprot.org/uniprot/B2KBB2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS04420 ^@ http://purl.uniprot.org/uniprot/B2KD22 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/445932:EMIN_RS06915 ^@ http://purl.uniprot.org/uniprot/B2KEG2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/445932:EMIN_RS07835 ^@ http://purl.uniprot.org/uniprot/B2KEY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/445932:EMIN_RS05305 ^@ http://purl.uniprot.org/uniprot/B2KDJ4 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/445932:EMIN_RS05950 ^@ http://purl.uniprot.org/uniprot/B2KDX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/445932:EMIN_RS07150 ^@ http://purl.uniprot.org/uniprot/B2KEL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS04680 ^@ http://purl.uniprot.org/uniprot/B2KD69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.|||Cell membrane http://togogenome.org/gene/445932:EMIN_RS07595 ^@ http://purl.uniprot.org/uniprot/B2KEU2 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/445932:EMIN_RS07745 ^@ http://purl.uniprot.org/uniprot/B2KEW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. http://togogenome.org/gene/445932:EMIN_RS03780 ^@ http://purl.uniprot.org/uniprot/B2KCP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/445932:EMIN_RS04665 ^@ http://purl.uniprot.org/uniprot/B2KD66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS07640 ^@ http://purl.uniprot.org/uniprot/B2KEM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/445932:EMIN_RS00025 ^@ http://purl.uniprot.org/uniprot/B2KAM7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/445932:EMIN_RS03630 ^@ http://purl.uniprot.org/uniprot/B2KCL4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS03430 ^@ http://purl.uniprot.org/uniprot/B2KC93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/445932:EMIN_RS06700 ^@ http://purl.uniprot.org/uniprot/B2KEC1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Homotetramer. http://togogenome.org/gene/445932:EMIN_RS06370 ^@ http://purl.uniprot.org/uniprot/B2KE55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06145 ^@ http://purl.uniprot.org/uniprot/B2KE11 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/445932:EMIN_RS01980 ^@ http://purl.uniprot.org/uniprot/B2KBC1 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/445932:EMIN_RS02690 ^@ http://purl.uniprot.org/uniprot/B2KCF2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS08795 ^@ http://purl.uniprot.org/uniprot/B2KEJ7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/445932:EMIN_RS01815 ^@ http://purl.uniprot.org/uniprot/B2KB92 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/445932:EMIN_RS00730 ^@ http://purl.uniprot.org/uniprot/B2KBM0 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/445932:EMIN_RS01440 ^@ http://purl.uniprot.org/uniprot/B2KBU1 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS06210 ^@ http://purl.uniprot.org/uniprot/B2KE24 ^@ Similarity ^@ Belongs to the alkaline phosphatase family. http://togogenome.org/gene/445932:EMIN_RS06825 ^@ http://purl.uniprot.org/uniprot/B2KEE5 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/445932:EMIN_RS02510 ^@ http://purl.uniprot.org/uniprot/B2KCC0 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/445932:EMIN_RS06940 ^@ http://purl.uniprot.org/uniprot/B2KEG7 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/445932:EMIN_RS00320 ^@ http://purl.uniprot.org/uniprot/B2KAT4 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/445932:EMIN_RS07720 ^@ http://purl.uniprot.org/uniprot/B2KEW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS00315 ^@ http://purl.uniprot.org/uniprot/B2KAT3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/445932:EMIN_RS03985 ^@ http://purl.uniprot.org/uniprot/B2KCT1 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS03195 ^@ http://purl.uniprot.org/uniprot/B2KC48 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/445932:EMIN_RS04725 ^@ http://purl.uniprot.org/uniprot/B2KD77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS02630 ^@ http://purl.uniprot.org/uniprot/B2KCE3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS01450 ^@ http://purl.uniprot.org/uniprot/B2KBU3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/445932:EMIN_RS05180 ^@ http://purl.uniprot.org/uniprot/B2KDH0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS03110 ^@ http://purl.uniprot.org/uniprot/B2KC31 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS06235 ^@ http://purl.uniprot.org/uniprot/B2KE29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS01070 ^@ http://purl.uniprot.org/uniprot/B2KB12 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/445932:EMIN_RS07660 ^@ http://purl.uniprot.org/uniprot/B2KEV2 ^@ Similarity|||Subunit ^@ Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/445932:EMIN_RS03435 ^@ http://purl.uniprot.org/uniprot/B2KC94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/445932:EMIN_RS03400 ^@ http://purl.uniprot.org/uniprot/B2KC87 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/445932:EMIN_RS05295 ^@ http://purl.uniprot.org/uniprot/B2KDJ2 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/445932:EMIN_RS02190 ^@ http://purl.uniprot.org/uniprot/B2KBF8 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/445932:EMIN_RS02125 ^@ http://purl.uniprot.org/uniprot/B2KBE7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/445932:EMIN_RS04395 ^@ http://purl.uniprot.org/uniprot/B2KD17 ^@ Similarity ^@ Belongs to the pseudomonas-type ThrB family. http://togogenome.org/gene/445932:EMIN_RS07235 ^@ http://purl.uniprot.org/uniprot/B2KEM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS05655 ^@ http://purl.uniprot.org/uniprot/B2KDR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS06870 ^@ http://purl.uniprot.org/uniprot/B2KEF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS07775 ^@ http://purl.uniprot.org/uniprot/B2KEX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/445932:EMIN_RS05820 ^@ http://purl.uniprot.org/uniprot/B2KDU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/445932:EMIN_RS00510 ^@ http://purl.uniprot.org/uniprot/B2KAX0 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/445932:EMIN_RS08020 ^@ http://purl.uniprot.org/uniprot/B2KBV9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS00960 ^@ http://purl.uniprot.org/uniprot/B2KBR5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/445932:EMIN_RS02865 ^@ http://purl.uniprot.org/uniprot/B2KCI7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS02140 ^@ http://purl.uniprot.org/uniprot/B2KBF0 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/445932:EMIN_RS00520 ^@ http://purl.uniprot.org/uniprot/B2KAX2 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/445932:EMIN_RS07510 ^@ http://purl.uniprot.org/uniprot/B2KES5 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/445932:EMIN_RS03755 ^@ http://purl.uniprot.org/uniprot/B2KCN7 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/445932:EMIN_RS01900 ^@ http://purl.uniprot.org/uniprot/B2KBA5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/445932:EMIN_RS05445 ^@ http://purl.uniprot.org/uniprot/B2KDM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05380 ^@ http://purl.uniprot.org/uniprot/B2KDK9 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/445932:EMIN_RS06470 ^@ http://purl.uniprot.org/uniprot/B2KE75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS07025 ^@ http://purl.uniprot.org/uniprot/B2KEI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01520 ^@ http://purl.uniprot.org/uniprot/B2KBV4 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/445932:EMIN_RS07160 ^@ http://purl.uniprot.org/uniprot/B2KEL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS06955 ^@ http://purl.uniprot.org/uniprot/B2KEH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS05830 ^@ http://purl.uniprot.org/uniprot/B2KDV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS03075 ^@ http://purl.uniprot.org/uniprot/B2KC24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/445932:EMIN_RS03535 ^@ http://purl.uniprot.org/uniprot/B2KCJ5 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/445932:EMIN_RS07630 ^@ http://purl.uniprot.org/uniprot/B2KEU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/445932:EMIN_RS00780 ^@ http://purl.uniprot.org/uniprot/B2KBN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS06710 ^@ http://purl.uniprot.org/uniprot/B2KEC3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS02005 ^@ http://purl.uniprot.org/uniprot/B2KBC6 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/445932:EMIN_RS02265 ^@ http://purl.uniprot.org/uniprot/B2KBH2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS05665 ^@ http://purl.uniprot.org/uniprot/B2KDR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS06285 ^@ http://purl.uniprot.org/uniprot/B2KE39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS04295 ^@ http://purl.uniprot.org/uniprot/B2KCZ6 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/445932:EMIN_RS02205 ^@ http://purl.uniprot.org/uniprot/B2KBG1 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/445932:EMIN_RS01240 ^@ http://purl.uniprot.org/uniprot/B2KB48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/445932:EMIN_RS07440 ^@ http://purl.uniprot.org/uniprot/B2KER1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/445932:EMIN_RS06250 ^@ http://purl.uniprot.org/uniprot/B2KE32 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/445932:EMIN_RS07095 ^@ http://purl.uniprot.org/uniprot/B2KEJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/445932:EMIN_RS05265 ^@ http://purl.uniprot.org/uniprot/B2KDI6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS01445 ^@ http://purl.uniprot.org/uniprot/B2KBU2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/445932:EMIN_RS04050 ^@ http://purl.uniprot.org/uniprot/B2KCU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06560 ^@ http://purl.uniprot.org/uniprot/B2KE93 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane http://togogenome.org/gene/445932:EMIN_RS07360 ^@ http://purl.uniprot.org/uniprot/B2KEP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05580 ^@ http://purl.uniprot.org/uniprot/B2KDQ0 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/445932:EMIN_RS00345 ^@ http://purl.uniprot.org/uniprot/B2KAT9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/445932:EMIN_RS03825 ^@ http://purl.uniprot.org/uniprot/B2KCQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/445932:EMIN_RS04715 ^@ http://purl.uniprot.org/uniprot/B2KD75 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/445932:EMIN_RS04590 ^@ http://purl.uniprot.org/uniprot/B2KD53 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/445932:EMIN_RS05360 ^@ http://purl.uniprot.org/uniprot/B2KDK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diaminopimelate dehydrogenase family.|||Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS04210 ^@ http://purl.uniprot.org/uniprot/B2KCX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS00100 ^@ http://purl.uniprot.org/uniprot/B2KAP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS02135 ^@ http://purl.uniprot.org/uniprot/B2KBE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS00855 ^@ http://purl.uniprot.org/uniprot/B2KBP5 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/445932:EMIN_RS07500 ^@ http://purl.uniprot.org/uniprot/B2KES3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. http://togogenome.org/gene/445932:EMIN_RS06190 ^@ http://purl.uniprot.org/uniprot/B2KE20 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/445932:EMIN_RS07695 ^@ http://purl.uniprot.org/uniprot/B2KEV9 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/445932:EMIN_RS04065 ^@ http://purl.uniprot.org/uniprot/B2KCU8 ^@ Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. http://togogenome.org/gene/445932:EMIN_RS01180 ^@ http://purl.uniprot.org/uniprot/B2KB36 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/445932:EMIN_RS01850 ^@ http://purl.uniprot.org/uniprot/B2KB98 ^@ Similarity ^@ Belongs to the UPF0162 family. http://togogenome.org/gene/445932:EMIN_RS03725 ^@ http://purl.uniprot.org/uniprot/B2KCN1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/445932:EMIN_RS00375 ^@ http://purl.uniprot.org/uniprot/B2KAU5 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/445932:EMIN_RS07110 ^@ http://purl.uniprot.org/uniprot/B2KEK1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/445932:EMIN_RS03185 ^@ http://purl.uniprot.org/uniprot/B2KC46 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS02150 ^@ http://purl.uniprot.org/uniprot/B2KBF2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS04200 ^@ http://purl.uniprot.org/uniprot/B2KCX6 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/445932:EMIN_RS03865 ^@ http://purl.uniprot.org/uniprot/B2KCQ8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/445932:EMIN_RS06820 ^@ http://purl.uniprot.org/uniprot/B2KEE4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/445932:EMIN_RS06610 ^@ http://purl.uniprot.org/uniprot/B2KEA3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/445932:EMIN_RS04645 ^@ http://purl.uniprot.org/uniprot/B2KD62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS03285 ^@ http://purl.uniprot.org/uniprot/B2KC64 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/445932:EMIN_RS02285 ^@ http://purl.uniprot.org/uniprot/B2KBH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS00805 ^@ http://purl.uniprot.org/uniprot/B2KBN5 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/445932:EMIN_RS05350 ^@ http://purl.uniprot.org/uniprot/B2KDK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05650 ^@ http://purl.uniprot.org/uniprot/B2KDR5 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/445932:EMIN_RS04735 ^@ http://purl.uniprot.org/uniprot/B2KD79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS03655 ^@ http://purl.uniprot.org/uniprot/B2KCL9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS00550 ^@ http://purl.uniprot.org/uniprot/B2KAX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell inner membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07365 ^@ http://purl.uniprot.org/uniprot/B2KEP6 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/445932:EMIN_RS01770 ^@ http://purl.uniprot.org/uniprot/B2KB84 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/445932:EMIN_RS05755 ^@ http://purl.uniprot.org/uniprot/B2KDT6 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/445932:EMIN_RS00650 ^@ http://purl.uniprot.org/uniprot/B2KAZ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/445932:EMIN_RS03485 ^@ http://purl.uniprot.org/uniprot/B2KCA5 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/445932:EMIN_RS01420 ^@ http://purl.uniprot.org/uniprot/B2KBT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/445932:EMIN_RS01355 ^@ http://purl.uniprot.org/uniprot/B2KBS7 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/445932:EMIN_RS07020 ^@ http://purl.uniprot.org/uniprot/B2KEI4 ^@ Function|||Similarity ^@ Belongs to the MreC family.|||Involved in formation and maintenance of cell shape. http://togogenome.org/gene/445932:EMIN_RS06230 ^@ http://purl.uniprot.org/uniprot/B2KE28 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/445932:EMIN_RS07770 ^@ http://purl.uniprot.org/uniprot/B2KEX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/445932:EMIN_RS05670 ^@ http://purl.uniprot.org/uniprot/B2KDR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Monomer. http://togogenome.org/gene/445932:EMIN_RS01650 ^@ http://purl.uniprot.org/uniprot/B2KBX9 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/445932:EMIN_RS00580 ^@ http://purl.uniprot.org/uniprot/B2KAY4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/445932:EMIN_RS00165 ^@ http://purl.uniprot.org/uniprot/B2KAQ4 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/445932:EMIN_RS07620 ^@ http://purl.uniprot.org/uniprot/B2KEU6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/445932:EMIN_RS01995 ^@ http://purl.uniprot.org/uniprot/B2KBC4 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/445932:EMIN_RS03620 ^@ http://purl.uniprot.org/uniprot/B2KCL2 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/445932:EMIN_RS04630 ^@ http://purl.uniprot.org/uniprot/B2KD59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS07505 ^@ http://purl.uniprot.org/uniprot/B2KES4 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/445932:EMIN_RS03000 ^@ http://purl.uniprot.org/uniprot/B2KC08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05275 ^@ http://purl.uniprot.org/uniprot/B2KDI8 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/445932:EMIN_RS03570 ^@ http://purl.uniprot.org/uniprot/B2KCK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/445932:EMIN_RS08420 ^@ http://purl.uniprot.org/uniprot/B2KE67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/445932:EMIN_RS00145 ^@ http://purl.uniprot.org/uniprot/B2KAQ0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS06960 ^@ http://purl.uniprot.org/uniprot/B2KEH1 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/445932:EMIN_RS02565 ^@ http://purl.uniprot.org/uniprot/B2KCD1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/445932:EMIN_RS01515 ^@ http://purl.uniprot.org/uniprot/B2KBV3 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/445932:EMIN_RS00455 ^@ http://purl.uniprot.org/uniprot/B2KAW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/445932:EMIN_RS00265 ^@ http://purl.uniprot.org/uniprot/B2KAS3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||May bind 1 zinc ion per subunit.|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/445932:EMIN_RS01990 ^@ http://purl.uniprot.org/uniprot/B2KBC3 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/445932:EMIN_RS02910 ^@ http://purl.uniprot.org/uniprot/B2KBZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/445932:EMIN_RS00275 ^@ http://purl.uniprot.org/uniprot/B2KAS5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/445932:EMIN_RS01745 ^@ http://purl.uniprot.org/uniprot/B2KB79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0073 (Hly-III) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS06350 ^@ http://purl.uniprot.org/uniprot/B2KE51 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/445932:EMIN_RS04925 ^@ http://purl.uniprot.org/uniprot/B2KDB6 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/445932:EMIN_RS01350 ^@ http://purl.uniprot.org/uniprot/B2KBS6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS07890 ^@ http://purl.uniprot.org/uniprot/B2KEZ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/445932:EMIN_RS07180 ^@ http://purl.uniprot.org/uniprot/B2KEL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). http://togogenome.org/gene/445932:EMIN_RS06715 ^@ http://purl.uniprot.org/uniprot/B2KEC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/445932:EMIN_RS06875 ^@ http://purl.uniprot.org/uniprot/B2KEF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS02435 ^@ http://purl.uniprot.org/uniprot/B2KBK4 ^@ Similarity ^@ Belongs to the iron-containing alcohol dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS04730 ^@ http://purl.uniprot.org/uniprot/B2KD78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS07495 ^@ http://purl.uniprot.org/uniprot/B2KES2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS00280 ^@ http://purl.uniprot.org/uniprot/B2KAS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/445932:EMIN_RS07005 ^@ http://purl.uniprot.org/uniprot/B2KEI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS00225 ^@ http://purl.uniprot.org/uniprot/B2KAR6 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/445932:EMIN_RS00810 ^@ http://purl.uniprot.org/uniprot/B2KBN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/445932:EMIN_RS04370 ^@ http://purl.uniprot.org/uniprot/B2KD12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05395 ^@ http://purl.uniprot.org/uniprot/B2KDL2 ^@ Function|||Similarity ^@ Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/445932:EMIN_RS06010 ^@ http://purl.uniprot.org/uniprot/B2KDY5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/445932:EMIN_RS03845 ^@ http://purl.uniprot.org/uniprot/B2KCQ4 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/445932:EMIN_RS07015 ^@ http://purl.uniprot.org/uniprot/B2KEI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS06405 ^@ http://purl.uniprot.org/uniprot/B2KE62 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/445932:EMIN_RS04745 ^@ http://purl.uniprot.org/uniprot/B2KD81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/445932:EMIN_RS04750 ^@ http://purl.uniprot.org/uniprot/B2KD82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/445932:EMIN_RS02745 ^@ http://purl.uniprot.org/uniprot/B2KCG3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/445932:EMIN_RS04150 ^@ http://purl.uniprot.org/uniprot/B2KCW5 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/445932:EMIN_RS04405 ^@ http://purl.uniprot.org/uniprot/B2KD19 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS07460 ^@ http://purl.uniprot.org/uniprot/B2KER5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS07960 ^@ http://purl.uniprot.org/uniprot/B2KAZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS00570 ^@ http://purl.uniprot.org/uniprot/B2KAY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS07540 ^@ http://purl.uniprot.org/uniprot/B2KET1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS03390 ^@ http://purl.uniprot.org/uniprot/B2KC85 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/445932:EMIN_RS07490 ^@ http://purl.uniprot.org/uniprot/B2KES1 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/445932:EMIN_RS01140 ^@ http://purl.uniprot.org/uniprot/B2KB27 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/445932:EMIN_RS03440 ^@ http://purl.uniprot.org/uniprot/B2KC95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/445932:EMIN_RS07575 ^@ http://purl.uniprot.org/uniprot/B2KET8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/445932:EMIN_RS05370 ^@ http://purl.uniprot.org/uniprot/B2KDK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05415 ^@ http://purl.uniprot.org/uniprot/B2KDL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.|||Cell inner membrane|||Mediates magnesium influx to the cytosol. http://togogenome.org/gene/445932:EMIN_RS02920 ^@ http://purl.uniprot.org/uniprot/B2KBZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07060 ^@ http://purl.uniprot.org/uniprot/B2KEJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/445932:EMIN_RS02030 ^@ http://purl.uniprot.org/uniprot/B2KBD0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS06500 ^@ http://purl.uniprot.org/uniprot/B2KE81 ^@ Similarity ^@ Belongs to the Pal lipoprotein family. http://togogenome.org/gene/445932:EMIN_RS06245 ^@ http://purl.uniprot.org/uniprot/B2KE31 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/445932:EMIN_RS01275 ^@ http://purl.uniprot.org/uniprot/B2KB56 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/445932:EMIN_RS02805 ^@ http://purl.uniprot.org/uniprot/B2KCH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell inner membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/445932:EMIN_RS08915 ^@ http://purl.uniprot.org/uniprot/B2KDC6 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/445932:EMIN_RS00675 ^@ http://purl.uniprot.org/uniprot/B2KB02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/445932:EMIN_RS03270 ^@ http://purl.uniprot.org/uniprot/B2KC61 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/445932:EMIN_RS01975 ^@ http://purl.uniprot.org/uniprot/B2KBC0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS02320 ^@ http://purl.uniprot.org/uniprot/B2KBI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell inner membrane|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/445932:EMIN_RS04030 ^@ http://purl.uniprot.org/uniprot/B2KCU1 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/445932:EMIN_RS03245 ^@ http://purl.uniprot.org/uniprot/B2KC57 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/445932:EMIN_RS01830 ^@ http://purl.uniprot.org/uniprot/B2KB94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/445932:EMIN_RS01680 ^@ http://purl.uniprot.org/uniprot/B2KBY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01410 ^@ http://purl.uniprot.org/uniprot/B2KBT5 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/445932:EMIN_RS00770 ^@ http://purl.uniprot.org/uniprot/B2KBM8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/445932:EMIN_RS00620 ^@ http://purl.uniprot.org/uniprot/B2KAZ1 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/445932:EMIN_RS01010 ^@ http://purl.uniprot.org/uniprot/B2KB03 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/445932:EMIN_RS02405 ^@ http://purl.uniprot.org/uniprot/B2KBJ8 ^@ Similarity ^@ Belongs to the barstar family. http://togogenome.org/gene/445932:EMIN_RS05995 ^@ http://purl.uniprot.org/uniprot/B2KDY2 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/445932:EMIN_RS03465 ^@ http://purl.uniprot.org/uniprot/B2KCA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS00640 ^@ http://purl.uniprot.org/uniprot/B2KAZ5 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/445932:EMIN_RS00870 ^@ http://purl.uniprot.org/uniprot/B2KBP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS03680 ^@ http://purl.uniprot.org/uniprot/B2KCM4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/445932:EMIN_RS06665 ^@ http://purl.uniprot.org/uniprot/B2KEB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS04285 ^@ http://purl.uniprot.org/uniprot/B2KCZ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M15D family.|||Binds 1 zinc ion per subunit.|||Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. http://togogenome.org/gene/445932:EMIN_RS01890 ^@ http://purl.uniprot.org/uniprot/B2KBA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07450 ^@ http://purl.uniprot.org/uniprot/B2KER3 ^@ Caution|||Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/445932:EMIN_RS08275 ^@ http://purl.uniprot.org/uniprot/B2KD55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/445932:EMIN_RS07170 ^@ http://purl.uniprot.org/uniprot/B2KEL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS00075 ^@ http://purl.uniprot.org/uniprot/B2KAN6 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/445932:EMIN_RS06835 ^@ http://purl.uniprot.org/uniprot/B2KEE7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS00385 ^@ http://purl.uniprot.org/uniprot/B2KAU7 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/445932:EMIN_RS07455 ^@ http://purl.uniprot.org/uniprot/B2KER4 ^@ Similarity|||Subunit ^@ Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/445932:EMIN_RS07755 ^@ http://purl.uniprot.org/uniprot/B2KEX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/445932:EMIN_RS08495 ^@ http://purl.uniprot.org/uniprot/B2KES0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/445932:EMIN_RS05875 ^@ http://purl.uniprot.org/uniprot/B2KDV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-ACP thioesterase family.|||chloroplast http://togogenome.org/gene/445932:EMIN_RS01460 ^@ http://purl.uniprot.org/uniprot/B2KBU5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/445932:EMIN_RS07205 ^@ http://purl.uniprot.org/uniprot/B2KEM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/445932:EMIN_RS06435 ^@ http://purl.uniprot.org/uniprot/B2KE68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/445932:EMIN_RS01945 ^@ http://purl.uniprot.org/uniprot/B2KBB4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/445932:EMIN_RS07765 ^@ http://purl.uniprot.org/uniprot/B2KEX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/445932:EMIN_RS02465 ^@ http://purl.uniprot.org/uniprot/B2KBL1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS06395 ^@ http://purl.uniprot.org/uniprot/B2KE60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/445932:EMIN_RS07135 ^@ http://purl.uniprot.org/uniprot/B2KEK6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL6 family.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/445932:EMIN_RS00540 ^@ http://purl.uniprot.org/uniprot/B2KAX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/445932:EMIN_RS02045 ^@ http://purl.uniprot.org/uniprot/B2KBD3 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/445932:EMIN_RS04785 ^@ http://purl.uniprot.org/uniprot/B2KD89 ^@ Similarity ^@ Belongs to the beta-eliminating lyase family. http://togogenome.org/gene/445932:EMIN_RS07175 ^@ http://purl.uniprot.org/uniprot/B2KEL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/445932:EMIN_RS01600 ^@ http://purl.uniprot.org/uniprot/B2KBX0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/445932:EMIN_RS03900 ^@ http://purl.uniprot.org/uniprot/B2KCR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/445932:EMIN_RS03315 ^@ http://purl.uniprot.org/uniprot/B2KC70 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/445932:EMIN_RS01925 ^@ http://purl.uniprot.org/uniprot/B2KBB0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/445932:EMIN_RS00445 ^@ http://purl.uniprot.org/uniprot/B2KAV8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS07070 ^@ http://purl.uniprot.org/uniprot/B2KEJ3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/445932:EMIN_RS07035 ^@ http://purl.uniprot.org/uniprot/B2KEI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01940 ^@ http://purl.uniprot.org/uniprot/B2KBB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS05885 ^@ http://purl.uniprot.org/uniprot/B2KDW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein S18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS06415 ^@ http://purl.uniprot.org/uniprot/B2KE64 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS00655 ^@ http://purl.uniprot.org/uniprot/B2KAZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS07075 ^@ http://purl.uniprot.org/uniprot/B2KEJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/445932:EMIN_RS02700 ^@ http://purl.uniprot.org/uniprot/B2KCF4 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/445932:EMIN_RS02995 ^@ http://purl.uniprot.org/uniprot/B2KC07 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/445932:EMIN_RS01765 ^@ http://purl.uniprot.org/uniprot/B2KB83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/445932:EMIN_RS02590 ^@ http://purl.uniprot.org/uniprot/B2KCD6 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/445932:EMIN_RS01810 ^@ http://purl.uniprot.org/uniprot/B2KB91 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/445932:EMIN_RS03055 ^@ http://purl.uniprot.org/uniprot/B2KC19 ^@ Similarity ^@ Belongs to the SIS family. GutQ/KpsF subfamily. http://togogenome.org/gene/445932:EMIN_RS07700 ^@ http://purl.uniprot.org/uniprot/B2KEW0 ^@ Function ^@ Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/445932:EMIN_RS05935 ^@ http://purl.uniprot.org/uniprot/B2KDX1 ^@ Caution|||Function|||Similarity ^@ Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).|||In the C-terminal section; belongs to the IspF family.|||In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS08090 ^@ http://purl.uniprot.org/uniprot/B2KBH3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/445932:EMIN_RS00240 ^@ http://purl.uniprot.org/uniprot/B2KAR9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/445932:EMIN_RS00705 ^@ http://purl.uniprot.org/uniprot/B2KBL5 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/445932:EMIN_RS03525 ^@ http://purl.uniprot.org/uniprot/B2KCB2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS03605 ^@ http://purl.uniprot.org/uniprot/B2KCK9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/445932:EMIN_RS00030 ^@ http://purl.uniprot.org/uniprot/B2KAM8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/445932:EMIN_RS00830 ^@ http://purl.uniprot.org/uniprot/B2KBP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/445932:EMIN_RS03470 ^@ http://purl.uniprot.org/uniprot/B2KCA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/445932:EMIN_RS02275 ^@ http://purl.uniprot.org/uniprot/B2KBH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS01125 ^@ http://purl.uniprot.org/uniprot/B2KB23 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/445932:EMIN_RS05835 ^@ http://purl.uniprot.org/uniprot/B2KDV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS06925 ^@ http://purl.uniprot.org/uniprot/B2KEG4 ^@ Function ^@ Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/445932:EMIN_RS03930 ^@ http://purl.uniprot.org/uniprot/B2KCS0 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/445932:EMIN_RS04905 ^@ http://purl.uniprot.org/uniprot/B2KDB1 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/445932:EMIN_RS02965 ^@ http://purl.uniprot.org/uniprot/B2KC01 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/445932:EMIN_RS01375 ^@ http://purl.uniprot.org/uniprot/B2KBS9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS01025 ^@ http://purl.uniprot.org/uniprot/B2KB05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS02625 ^@ http://purl.uniprot.org/uniprot/B2KCE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/445932:EMIN_RS06935 ^@ http://purl.uniprot.org/uniprot/B2KEG6 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/445932:EMIN_RS07565 ^@ http://purl.uniprot.org/uniprot/B2KET6 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/445932:EMIN_RS05330 ^@ http://purl.uniprot.org/uniprot/B2KDJ9 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/445932:EMIN_RS02610 ^@ http://purl.uniprot.org/uniprot/B2KCD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/445932:EMIN_RS03240 ^@ http://purl.uniprot.org/uniprot/B2KC56 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/445932:EMIN_RS05685 ^@ http://purl.uniprot.org/uniprot/B2KDS2 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/445932:EMIN_RS05375 ^@ http://purl.uniprot.org/uniprot/B2KDK8 ^@ Similarity ^@ Belongs to the hemerythrin family. http://togogenome.org/gene/445932:EMIN_RS05575 ^@ http://purl.uniprot.org/uniprot/B2KDP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS00185 ^@ http://purl.uniprot.org/uniprot/B2KAQ8 ^@ Similarity ^@ Belongs to the DapB family. http://togogenome.org/gene/445932:EMIN_RS06475 ^@ http://purl.uniprot.org/uniprot/B2KE76 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/445932:EMIN_RS02040 ^@ http://purl.uniprot.org/uniprot/B2KBD2 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/445932:EMIN_RS02755 ^@ http://purl.uniprot.org/uniprot/B2KCG5 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/445932:EMIN_RS01330 ^@ http://purl.uniprot.org/uniprot/B2KB67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS01540 ^@ http://purl.uniprot.org/uniprot/B2KBV8 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/445932:EMIN_RS07255 ^@ http://purl.uniprot.org/uniprot/B2KEN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/445932:EMIN_RS04495 ^@ http://purl.uniprot.org/uniprot/B2KD37 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/445932:EMIN_RS06380 ^@ http://purl.uniprot.org/uniprot/B2KE57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS02035 ^@ http://purl.uniprot.org/uniprot/B2KBD1 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/445932:EMIN_RS03760 ^@ http://purl.uniprot.org/uniprot/B2KCN8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS07370 ^@ http://purl.uniprot.org/uniprot/B2KEP7 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/445932:EMIN_RS07165 ^@ http://purl.uniprot.org/uniprot/B2KEL3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/445932:EMIN_RS03615 ^@ http://purl.uniprot.org/uniprot/B2KCL1 ^@ Similarity ^@ Belongs to the peptidase S13 family. http://togogenome.org/gene/445932:EMIN_RS07200 ^@ http://purl.uniprot.org/uniprot/B2KEM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS03555 ^@ http://purl.uniprot.org/uniprot/B2KCJ9 ^@ Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/445932:EMIN_RS07045 ^@ http://purl.uniprot.org/uniprot/B2KEI8 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/445932:EMIN_RS05865 ^@ http://purl.uniprot.org/uniprot/B2KDV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS03350 ^@ http://purl.uniprot.org/uniprot/B2KC77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS00015 ^@ http://purl.uniprot.org/uniprot/B2KAM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/445932:EMIN_RS03640 ^@ http://purl.uniprot.org/uniprot/B2KCL6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS01000 ^@ http://purl.uniprot.org/uniprot/B2KBS3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/445932:EMIN_RS00360 ^@ http://purl.uniprot.org/uniprot/B2KAU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06460 ^@ http://purl.uniprot.org/uniprot/B2KE73 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/445932:EMIN_RS02615 ^@ http://purl.uniprot.org/uniprot/B2KCE0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/445932:EMIN_RS06570 ^@ http://purl.uniprot.org/uniprot/B2KE95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/445932:EMIN_RS04410 ^@ http://purl.uniprot.org/uniprot/B2KD20 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/445932:EMIN_RS06890 ^@ http://purl.uniprot.org/uniprot/B2KEF7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/445932:EMIN_RS00815 ^@ http://purl.uniprot.org/uniprot/B2KBN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/445932:EMIN_RS02930 ^@ http://purl.uniprot.org/uniprot/B2KBZ4 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS07185 ^@ http://purl.uniprot.org/uniprot/B2KEL7 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/445932:EMIN_RS06130 ^@ http://purl.uniprot.org/uniprot/B2KE08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05980 ^@ http://purl.uniprot.org/uniprot/B2KDX9 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/445932:EMIN_RS07790 ^@ http://purl.uniprot.org/uniprot/B2KEX7 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/445932:EMIN_RS04315 ^@ http://purl.uniprot.org/uniprot/B2KD00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS08070 ^@ http://purl.uniprot.org/uniprot/B2KBD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05695 ^@ http://purl.uniprot.org/uniprot/B2KDS4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/445932:EMIN_RS00215 ^@ http://purl.uniprot.org/uniprot/B2KAR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/445932:EMIN_RS07785 ^@ http://purl.uniprot.org/uniprot/B2KEX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/445932:EMIN_RS04310 ^@ http://purl.uniprot.org/uniprot/B2KCZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/445932:EMIN_RS06215 ^@ http://purl.uniprot.org/uniprot/B2KE25 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/445932:EMIN_RS05160 ^@ http://purl.uniprot.org/uniprot/B2KDG6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-I family. http://togogenome.org/gene/445932:EMIN_RS05170 ^@ http://purl.uniprot.org/uniprot/B2KDG8 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/445932:EMIN_RS04620 ^@ http://purl.uniprot.org/uniprot/B2KD57 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily. http://togogenome.org/gene/445932:EMIN_RS07030 ^@ http://purl.uniprot.org/uniprot/B2KEI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS02065 ^@ http://purl.uniprot.org/uniprot/B2KBD7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/445932:EMIN_RS07935 ^@ http://purl.uniprot.org/uniprot/B2KAN8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07245 ^@ http://purl.uniprot.org/uniprot/B2KEM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/445932:EMIN_RS04320 ^@ http://purl.uniprot.org/uniprot/B2KD01 ^@ Function|||Similarity ^@ Belongs to the transglycosylase MltG family.|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/445932:EMIN_RS04280 ^@ http://purl.uniprot.org/uniprot/B2KCZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS04355 ^@ http://purl.uniprot.org/uniprot/B2KD08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS03120 ^@ http://purl.uniprot.org/uniprot/B2KC33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS00785 ^@ http://purl.uniprot.org/uniprot/B2KBN1 ^@ Function|||Similarity ^@ Belongs to the DnaA family.|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/445932:EMIN_RS01590 ^@ http://purl.uniprot.org/uniprot/B2KBW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/445932:EMIN_RS05115 ^@ http://purl.uniprot.org/uniprot/B2KDF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/445932:EMIN_RS05945 ^@ http://purl.uniprot.org/uniprot/B2KDX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/445932:EMIN_RS00380 ^@ http://purl.uniprot.org/uniprot/B2KAU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/445932:EMIN_RS01750 ^@ http://purl.uniprot.org/uniprot/B2KB80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05870 ^@ http://purl.uniprot.org/uniprot/B2KDV8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/445932:EMIN_RS03130 ^@ http://purl.uniprot.org/uniprot/B2KC35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS06005 ^@ http://purl.uniprot.org/uniprot/B2KDY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS07750 ^@ http://purl.uniprot.org/uniprot/B2KEW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/445932:EMIN_RS05085 ^@ http://purl.uniprot.org/uniprot/B2KDF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS01095 ^@ http://purl.uniprot.org/uniprot/B2KB17 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/445932:EMIN_RS07605 ^@ http://purl.uniprot.org/uniprot/B2KEU4 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/445932:EMIN_RS00330 ^@ http://purl.uniprot.org/uniprot/B2KAT6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/445932:EMIN_RS03925 ^@ http://purl.uniprot.org/uniprot/B2KCR9 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/445932:EMIN_RS00430 ^@ http://purl.uniprot.org/uniprot/B2KAV5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/445932:EMIN_RS05770 ^@ http://purl.uniprot.org/uniprot/B2KDT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Cell membrane|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/445932:EMIN_RS06135 ^@ http://purl.uniprot.org/uniprot/B2KE09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05560 ^@ http://purl.uniprot.org/uniprot/B2KDP6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS07120 ^@ http://purl.uniprot.org/uniprot/B2KEK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/445932:EMIN_RS06255 ^@ http://purl.uniprot.org/uniprot/B2KE33 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/445932:EMIN_RS04515 ^@ http://purl.uniprot.org/uniprot/B2KD41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05925 ^@ http://purl.uniprot.org/uniprot/B2KDW9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/445932:EMIN_RS02260 ^@ http://purl.uniprot.org/uniprot/B2KBH1 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. http://togogenome.org/gene/445932:EMIN_RS08455 ^@ http://purl.uniprot.org/uniprot/B2KEH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05195 ^@ http://purl.uniprot.org/uniprot/B2KDH3 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/445932:EMIN_RS03830 ^@ http://purl.uniprot.org/uniprot/B2KCQ1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/445932:EMIN_RS06625 ^@ http://purl.uniprot.org/uniprot/B2KEA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS07515 ^@ http://purl.uniprot.org/uniprot/B2KES6 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/445932:EMIN_RS00065 ^@ http://purl.uniprot.org/uniprot/B2KAN4 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/445932:EMIN_RS07115 ^@ http://purl.uniprot.org/uniprot/B2KEK2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/445932:EMIN_RS03705 ^@ http://purl.uniprot.org/uniprot/B2KCM9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/445932:EMIN_RS07795 ^@ http://purl.uniprot.org/uniprot/B2KEX8 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/445932:EMIN_RS03860 ^@ http://purl.uniprot.org/uniprot/B2KCQ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. http://togogenome.org/gene/445932:EMIN_RS03060 ^@ http://purl.uniprot.org/uniprot/B2KC21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01595 ^@ http://purl.uniprot.org/uniprot/B2KBW9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/445932:EMIN_RS07675 ^@ http://purl.uniprot.org/uniprot/B2KEV5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/445932:EMIN_RS05355 ^@ http://purl.uniprot.org/uniprot/B2KDK4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/445932:EMIN_RS03765 ^@ http://purl.uniprot.org/uniprot/B2KCN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS05910 ^@ http://purl.uniprot.org/uniprot/B2KDW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05790 ^@ http://purl.uniprot.org/uniprot/B2KDU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS07310 ^@ http://purl.uniprot.org/uniprot/B2KEP2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/445932:EMIN_RS07240 ^@ http://purl.uniprot.org/uniprot/B2KEM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/445932:EMIN_RS02570 ^@ http://purl.uniprot.org/uniprot/B2KCD2 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/445932:EMIN_RS01290 ^@ http://purl.uniprot.org/uniprot/B2KB59 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS01970 ^@ http://purl.uniprot.org/uniprot/B2KBB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS03105 ^@ http://purl.uniprot.org/uniprot/B2KC30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/445932:EMIN_RS04175 ^@ http://purl.uniprot.org/uniprot/B2KCX0 ^@ Similarity ^@ Belongs to the UPF0597 family. http://togogenome.org/gene/445932:EMIN_RS03740 ^@ http://purl.uniprot.org/uniprot/B2KCN4 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/445932:EMIN_RS03295 ^@ http://purl.uniprot.org/uniprot/B2KC66 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily. http://togogenome.org/gene/445932:EMIN_RS01655 ^@ http://purl.uniprot.org/uniprot/B2KBY0 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/445932:EMIN_RS07140 ^@ http://purl.uniprot.org/uniprot/B2KEK7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/445932:EMIN_RS03175 ^@ http://purl.uniprot.org/uniprot/B2KC44 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/445932:EMIN_RS00925 ^@ http://purl.uniprot.org/uniprot/B2KBQ8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/445932:EMIN_RS03695 ^@ http://purl.uniprot.org/uniprot/B2KCM7 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/445932:EMIN_RS07920 ^@ http://purl.uniprot.org/uniprot/B2KF01 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/445932:EMIN_RS07590 ^@ http://purl.uniprot.org/uniprot/B2KEU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/445932:EMIN_RS01345 ^@ http://purl.uniprot.org/uniprot/B2KBS5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/445932:EMIN_RS00800 ^@ http://purl.uniprot.org/uniprot/B2KBN4 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/445932:EMIN_RS05150 ^@ http://purl.uniprot.org/uniprot/B2KDG4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/445932:EMIN_RS01100 ^@ http://purl.uniprot.org/uniprot/B2KB18 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/445932:EMIN_RS07100 ^@ http://purl.uniprot.org/uniprot/B2KEJ9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/445932:EMIN_RS06495 ^@ http://purl.uniprot.org/uniprot/B2KE80 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/445932:EMIN_RS03135 ^@ http://purl.uniprot.org/uniprot/B2KC36 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/445932:EMIN_RS00700 ^@ http://purl.uniprot.org/uniprot/B2KBL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS05775 ^@ http://purl.uniprot.org/uniprot/B2KDU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/445932:EMIN_RS06885 ^@ http://purl.uniprot.org/uniprot/B2KEF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/445932:EMIN_RS00110 ^@ http://purl.uniprot.org/uniprot/B2KAP3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/445932:EMIN_RS03675 ^@ http://purl.uniprot.org/uniprot/B2KCM3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/445932:EMIN_RS08080 ^@ http://purl.uniprot.org/uniprot/B2KBE8 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/445932:EMIN_RS01775 ^@ http://purl.uniprot.org/uniprot/B2KB85 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/445932:EMIN_RS05990 ^@ http://purl.uniprot.org/uniprot/B2KDY1 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/445932:EMIN_RS00840 ^@ http://purl.uniprot.org/uniprot/B2KBP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/445932:EMIN_RS06905 ^@ http://purl.uniprot.org/uniprot/B2KEG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/445932:EMIN_RS03955 ^@ http://purl.uniprot.org/uniprot/B2KCS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/445932:EMIN_RS05895 ^@ http://purl.uniprot.org/uniprot/B2KDW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/445932:EMIN_RS00060 ^@ http://purl.uniprot.org/uniprot/B2KAN3 ^@ Function|||Similarity ^@ Belongs to the desulfoferrodoxin family.|||Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.