http://togogenome.org/gene/39695:G6N58_RS16025 ^@ http://purl.uniprot.org/uniprot/A0A378TDX7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/39695:G6N58_RS27440 ^@ http://purl.uniprot.org/uniprot/A0A378TPV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with subunits I, II and III to form cytochrome c oxidase.|||Belongs to the cytochrome c oxidase bacterial subunit CtaF family.|||Cell membrane|||Membrane|||Part of cytochrome c oxidase, its function is unknown. http://togogenome.org/gene/39695:G6N58_RS18750 ^@ http://purl.uniprot.org/uniprot/A0A378T9P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/39695:G6N58_RS14335 ^@ http://purl.uniprot.org/uniprot/A0A378TD46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS10440 ^@ http://purl.uniprot.org/uniprot/A0A378TEE7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/39695:G6N58_RS08460 ^@ http://purl.uniprot.org/uniprot/A0A378TJ53 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/39695:G6N58_RS13660 ^@ http://purl.uniprot.org/uniprot/A0A378TCP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS22205 ^@ http://purl.uniprot.org/uniprot/A0A378T8Q7 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/39695:G6N58_RS20190 ^@ http://purl.uniprot.org/uniprot/A0A378T8R2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/39695:G6N58_RS20285 ^@ http://purl.uniprot.org/uniprot/A0A378T8N8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS27195 ^@ http://purl.uniprot.org/uniprot/A0A378TQ10 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/39695:G6N58_RS16160 ^@ http://purl.uniprot.org/uniprot/A0A378TCZ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/39695:G6N58_RS12145 ^@ http://purl.uniprot.org/uniprot/A0A378TGB2 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/39695:G6N58_RS10820 ^@ http://purl.uniprot.org/uniprot/A0A378THR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DisA family.|||Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.|||Homooctamer.|||Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. http://togogenome.org/gene/39695:G6N58_RS19735 ^@ http://purl.uniprot.org/uniprot/A0A378TBT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/39695:G6N58_RS00675 ^@ http://purl.uniprot.org/uniprot/A0A378TMQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS16690 ^@ http://purl.uniprot.org/uniprot/A0A378TBT4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/39695:G6N58_RS21375 ^@ http://purl.uniprot.org/uniprot/A0A378T826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/39695:G6N58_RS15550 ^@ http://purl.uniprot.org/uniprot/A0A378TCG7 ^@ Similarity ^@ Belongs to the UPF0336 family. http://togogenome.org/gene/39695:G6N58_RS17820 ^@ http://purl.uniprot.org/uniprot/A0A378TDT0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/39695:G6N58_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A378TIP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A378TI42 ^@ Similarity ^@ Belongs to the WXG100 family. http://togogenome.org/gene/39695:G6N58_RS06000 ^@ http://purl.uniprot.org/uniprot/A0A378TGY7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS13425 ^@ http://purl.uniprot.org/uniprot/A0A378TFD0 ^@ Similarity ^@ Belongs to the UPF0225 family. http://togogenome.org/gene/39695:G6N58_RS19415 ^@ http://purl.uniprot.org/uniprot/A0A378TBV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS16360 ^@ http://purl.uniprot.org/uniprot/A0A378TEN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/39695:G6N58_RS04765 ^@ http://purl.uniprot.org/uniprot/A0A378TKI8 ^@ Function|||Similarity ^@ Belongs to the Stf0 sulfotransferase family.|||Catalyzes the sulfuryl group transfer from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S). http://togogenome.org/gene/39695:G6N58_RS24315 ^@ http://purl.uniprot.org/uniprot/A0A378TNZ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/39695:G6N58_RS14480 ^@ http://purl.uniprot.org/uniprot/A0A378TER6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS17230 ^@ http://purl.uniprot.org/uniprot/A0A378TBG7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/39695:G6N58_RS24410 ^@ http://purl.uniprot.org/uniprot/A0A378TRJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sbp family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS04230 ^@ http://purl.uniprot.org/uniprot/A0A378TIQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS05120 ^@ http://purl.uniprot.org/uniprot/A0A378TKB8 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/39695:G6N58_RS17575 ^@ http://purl.uniprot.org/uniprot/A0A378TB91 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase. http://togogenome.org/gene/39695:G6N58_RS10630 ^@ http://purl.uniprot.org/uniprot/A0A378TH23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/39695:G6N58_RS14270 ^@ http://purl.uniprot.org/uniprot/A0A378TE03 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/39695:G6N58_RS19335 ^@ http://purl.uniprot.org/uniprot/A0A378T980 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable amino-acid or metabolite transport protein. http://togogenome.org/gene/39695:G6N58_RS16030 ^@ http://purl.uniprot.org/uniprot/A0A378TB46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/39695:G6N58_RS29275 ^@ http://purl.uniprot.org/uniprot/A0A378TPF9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/39695:G6N58_RS16020 ^@ http://purl.uniprot.org/uniprot/A0A378TC71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/39695:G6N58_RS12585 ^@ http://purl.uniprot.org/uniprot/A0A378TGS5 ^@ Similarity ^@ Belongs to the non-flavoprotein flavin reductase family. http://togogenome.org/gene/39695:G6N58_RS27565 ^@ http://purl.uniprot.org/uniprot/A0A378TM46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/39695:G6N58_RS23155 ^@ http://purl.uniprot.org/uniprot/A0A378T9T9 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/39695:G6N58_RS16005 ^@ http://purl.uniprot.org/uniprot/A0A378TD23 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/39695:G6N58_RS14620 ^@ http://purl.uniprot.org/uniprot/A0A378TDU1 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/39695:G6N58_RS15950 ^@ http://purl.uniprot.org/uniprot/A0A378TB64 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/39695:G6N58_RS22305 ^@ http://purl.uniprot.org/uniprot/A0A378T8N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS14810 ^@ http://purl.uniprot.org/uniprot/A0A378TC05 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/39695:G6N58_RS04640 ^@ http://purl.uniprot.org/uniprot/A0A378THR9 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/39695:G6N58_RS19230 ^@ http://purl.uniprot.org/uniprot/A0A378TC34 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/39695:G6N58_RS15570 ^@ http://purl.uniprot.org/uniprot/A0A378TBH6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/39695:G6N58_RS15535 ^@ http://purl.uniprot.org/uniprot/A0A378TDB9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/39695:G6N58_RS16015 ^@ http://purl.uniprot.org/uniprot/A0A378TDW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/39695:G6N58_RS11750 ^@ http://purl.uniprot.org/uniprot/A0A378TDQ3 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/39695:G6N58_RS20865 ^@ http://purl.uniprot.org/uniprot/A0A378TB39 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/39695:G6N58_RS21305 ^@ http://purl.uniprot.org/uniprot/A0A378TBU2 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/39695:G6N58_RS11595 ^@ http://purl.uniprot.org/uniprot/A0A378TGL7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS19885 ^@ http://purl.uniprot.org/uniprot/A0A378TBQ3 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/39695:G6N58_RS27280 ^@ http://purl.uniprot.org/uniprot/A0A378TQ59 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/39695:G6N58_RS22290 ^@ http://purl.uniprot.org/uniprot/A0A378T9F6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/39695:G6N58_RS19870 ^@ http://purl.uniprot.org/uniprot/A0A378TCM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/39695:G6N58_RS22860 ^@ http://purl.uniprot.org/uniprot/A0A378T7A9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/39695:G6N58_RS16170 ^@ http://purl.uniprot.org/uniprot/A0A378TDS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/39695:G6N58_RS21740 ^@ http://purl.uniprot.org/uniprot/A0A378T811 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/39695:G6N58_RS06765 ^@ http://purl.uniprot.org/uniprot/A0A378TJE8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS05760 ^@ http://purl.uniprot.org/uniprot/A0A378TH33 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/39695:G6N58_RS25400 ^@ http://purl.uniprot.org/uniprot/A0A378TNY8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS16630 ^@ http://purl.uniprot.org/uniprot/A0A378TEI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. http://togogenome.org/gene/39695:G6N58_RS17495 ^@ http://purl.uniprot.org/uniprot/A0A378TAD7 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/39695:G6N58_RS13230 ^@ http://purl.uniprot.org/uniprot/A0A378TDP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS13055 ^@ http://purl.uniprot.org/uniprot/A0A378TDF1 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/39695:G6N58_RS05465 ^@ http://purl.uniprot.org/uniprot/A0A378TK45 ^@ Similarity ^@ Belongs to the NtaA/SnaA/DszA monooxygenase family. http://togogenome.org/gene/39695:G6N58_RS12180 ^@ http://purl.uniprot.org/uniprot/A0A378TH05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS15775 ^@ http://purl.uniprot.org/uniprot/A0A378TE33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/39695:G6N58_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A378THF7 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/39695:G6N58_RS12560 ^@ http://purl.uniprot.org/uniprot/A0A378TD73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS08660 ^@ http://purl.uniprot.org/uniprot/A0A378TH85 ^@ Similarity ^@ Belongs to the UPF0310 family. http://togogenome.org/gene/39695:G6N58_RS16500 ^@ http://purl.uniprot.org/uniprot/A0A378TBX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/39695:G6N58_RS09960 ^@ http://purl.uniprot.org/uniprot/A0A378TI93 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/39695:G6N58_RS16370 ^@ http://purl.uniprot.org/uniprot/A0A378TC06 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/39695:G6N58_RS09845 ^@ http://purl.uniprot.org/uniprot/A0A378TEY0 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. http://togogenome.org/gene/39695:G6N58_RS17070 ^@ http://purl.uniprot.org/uniprot/A0A378TAI6 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/39695:G6N58_RS12410 ^@ http://purl.uniprot.org/uniprot/A0A378TDB2 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/39695:G6N58_RS20660 ^@ http://purl.uniprot.org/uniprot/A0A378T9K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/39695:G6N58_RS01320 ^@ http://purl.uniprot.org/uniprot/A0A378TMC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS19680 ^@ http://purl.uniprot.org/uniprot/A0A378T905 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/39695:G6N58_RS20870 ^@ http://purl.uniprot.org/uniprot/A0A378T8C5 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/39695:G6N58_RS16375 ^@ http://purl.uniprot.org/uniprot/A0A378TDQ4 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/39695:G6N58_RS03800 ^@ http://purl.uniprot.org/uniprot/A0A378TI85 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/39695:G6N58_RS19265 ^@ http://purl.uniprot.org/uniprot/A0A378TCZ6 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Electron transport system for the ribonucleotide reductase system NrdEF. http://togogenome.org/gene/39695:G6N58_RS15350 ^@ http://purl.uniprot.org/uniprot/A0A378TBK7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS19980 ^@ http://purl.uniprot.org/uniprot/A0A378T9Y9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/39695:G6N58_RS16270 ^@ http://purl.uniprot.org/uniprot/A0A378TC24 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS07185 ^@ http://purl.uniprot.org/uniprot/A0A378TI43 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/39695:G6N58_RS14100 ^@ http://purl.uniprot.org/uniprot/A0A378TCT1 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/39695:G6N58_RS05680 ^@ http://purl.uniprot.org/uniprot/A0A378TH54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNT beta subunit family.|||Cell inner membrane|||Membrane|||The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/39695:G6N58_RS20905 ^@ http://purl.uniprot.org/uniprot/A0A378TB06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/39695:G6N58_RS16355 ^@ http://purl.uniprot.org/uniprot/A0A378TCW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/39695:G6N58_RS22685 ^@ http://purl.uniprot.org/uniprot/A0A378TA07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS10855 ^@ http://purl.uniprot.org/uniprot/A0A378TEB9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/39695:G6N58_RS16150 ^@ http://purl.uniprot.org/uniprot/A0A378TBA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/39695:G6N58_RS16145 ^@ http://purl.uniprot.org/uniprot/A0A378TBN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/39695:G6N58_RS17445 ^@ http://purl.uniprot.org/uniprot/A0A378TAE7 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/39695:G6N58_RS22050 ^@ http://purl.uniprot.org/uniprot/A0A378TAD5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/39695:G6N58_RS22115 ^@ http://purl.uniprot.org/uniprot/A0A378T7M0 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/39695:G6N58_RS10095 ^@ http://purl.uniprot.org/uniprot/A0A378TEN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS16880 ^@ http://purl.uniprot.org/uniprot/A0A378TED3 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/39695:G6N58_RS08415 ^@ http://purl.uniprot.org/uniprot/A0A378TIF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/39695:G6N58_RS09015 ^@ http://purl.uniprot.org/uniprot/A0A378TF72 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/39695:G6N58_RS16655 ^@ http://purl.uniprot.org/uniprot/A0A378TAV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/39695:G6N58_RS15860 ^@ http://purl.uniprot.org/uniprot/A0A378TEY8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/39695:G6N58_RS10040 ^@ http://purl.uniprot.org/uniprot/A0A378TEU6 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/39695:G6N58_RS19910 ^@ http://purl.uniprot.org/uniprot/A0A378T8V9 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/39695:G6N58_RS19495 ^@ http://purl.uniprot.org/uniprot/A0A378T993 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/39695:G6N58_RS21975 ^@ http://purl.uniprot.org/uniprot/A0A378T7P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS19895 ^@ http://purl.uniprot.org/uniprot/A0A378T8X2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS12195 ^@ http://purl.uniprot.org/uniprot/A0A378TGA0 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the nitrobindin family.|||Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.|||Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.|||Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS20815 ^@ http://purl.uniprot.org/uniprot/A0A378TB49 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS06995 ^@ http://purl.uniprot.org/uniprot/A0A378TI82 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable amino-acid or metabolite transport protein. http://togogenome.org/gene/39695:G6N58_RS05735 ^@ http://purl.uniprot.org/uniprot/A0A378TIX7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/39695:G6N58_RS15070 ^@ http://purl.uniprot.org/uniprot/A0A378TDJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS16125 ^@ http://purl.uniprot.org/uniprot/A0A378TC49 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS18620 ^@ http://purl.uniprot.org/uniprot/A0A378TCA8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/39695:G6N58_RS09630 ^@ http://purl.uniprot.org/uniprot/A0A378TF26 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/39695:G6N58_RS21930 ^@ http://purl.uniprot.org/uniprot/A0A378T7R3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/39695:G6N58_RS08130 ^@ http://purl.uniprot.org/uniprot/A0A378THJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/39695:G6N58_RS15995 ^@ http://purl.uniprot.org/uniprot/A0A378TBC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/39695:G6N58_RS25710 ^@ http://purl.uniprot.org/uniprot/A0A378TN62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS15305 ^@ http://purl.uniprot.org/uniprot/A0A378TC48 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/39695:G6N58_RS19460 ^@ http://purl.uniprot.org/uniprot/A0A378TCV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/39695:G6N58_RS09890 ^@ http://purl.uniprot.org/uniprot/A0A378TF81 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/39695:G6N58_RS27990 ^@ http://purl.uniprot.org/uniprot/A0A378TMA5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Acyl carrier protein involved in meromycolate extension.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/39695:G6N58_RS14105 ^@ http://purl.uniprot.org/uniprot/A0A378TCE8 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/39695:G6N58_RS14240 ^@ http://purl.uniprot.org/uniprot/A0A378TF13 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/39695:G6N58_RS10600 ^@ http://purl.uniprot.org/uniprot/A0A378TEC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/39695:G6N58_RS05320 ^@ http://purl.uniprot.org/uniprot/A0A378THC7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm|||Monomer. http://togogenome.org/gene/39695:G6N58_RS13135 ^@ http://purl.uniprot.org/uniprot/A0A378TDQ9 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/39695:G6N58_RS21320 ^@ http://purl.uniprot.org/uniprot/A0A378TAV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/39695:G6N58_RS20065 ^@ http://purl.uniprot.org/uniprot/A0A378TCI6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/39695:G6N58_RS08675 ^@ http://purl.uniprot.org/uniprot/A0A378TG74 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/39695:G6N58_RS19650 ^@ http://purl.uniprot.org/uniprot/A0A378T906 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/39695:G6N58_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A378TKD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/39695:G6N58_RS12920 ^@ http://purl.uniprot.org/uniprot/A0A378TD01 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/39695:G6N58_RS03955 ^@ http://purl.uniprot.org/uniprot/A0A378TI57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS09315 ^@ http://purl.uniprot.org/uniprot/A0A378TF15 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/39695:G6N58_RS10230 ^@ http://purl.uniprot.org/uniprot/A0A378TEI6 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/39695:G6N58_RS12290 ^@ http://purl.uniprot.org/uniprot/A0A378TDA6 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/39695:G6N58_RS00700 ^@ http://purl.uniprot.org/uniprot/A0A378TK20 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/39695:G6N58_RS06980 ^@ http://purl.uniprot.org/uniprot/A0A378TGV0 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/39695:G6N58_RS10810 ^@ http://purl.uniprot.org/uniprot/A0A378TE93 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/39695:G6N58_RS17090 ^@ http://purl.uniprot.org/uniprot/A0A378TBJ3 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/39695:G6N58_RS08875 ^@ http://purl.uniprot.org/uniprot/A0A378TFA1 ^@ Similarity ^@ Belongs to the FAD-binding monooxygenase family. http://togogenome.org/gene/39695:G6N58_RS14830 ^@ http://purl.uniprot.org/uniprot/A0A378TEI8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/39695:G6N58_RS20380 ^@ http://purl.uniprot.org/uniprot/A0A378T8M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/39695:G6N58_RS12440 ^@ http://purl.uniprot.org/uniprot/A0A378TFZ6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS19985 ^@ http://purl.uniprot.org/uniprot/A0A378TBN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A probable RNA-binding protein.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm http://togogenome.org/gene/39695:G6N58_RS16795 ^@ http://purl.uniprot.org/uniprot/A0A378TDI0 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/39695:G6N58_RS19905 ^@ http://purl.uniprot.org/uniprot/A0A378T915 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS14610 ^@ http://purl.uniprot.org/uniprot/A0A378TC39 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/39695:G6N58_RS22200 ^@ http://purl.uniprot.org/uniprot/A0A378TAA6 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/39695:G6N58_RS05430 ^@ http://purl.uniprot.org/uniprot/A0A378THR7 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/39695:G6N58_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A378TIT8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS15980 ^@ http://purl.uniprot.org/uniprot/A0A378TB60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/39695:G6N58_RS16010 ^@ http://purl.uniprot.org/uniprot/A0A378TEW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/39695:G6N58_RS09470 ^@ http://purl.uniprot.org/uniprot/A0A378TFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS21270 ^@ http://purl.uniprot.org/uniprot/A0A378TAV8 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS16390 ^@ http://purl.uniprot.org/uniprot/A0A378TBJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/39695:G6N58_RS20710 ^@ http://purl.uniprot.org/uniprot/A0A378T9J7 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/39695:G6N58_RS21370 ^@ http://purl.uniprot.org/uniprot/A0A378TAT7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/39695:G6N58_RS19485 ^@ http://purl.uniprot.org/uniprot/A0A378T952 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS15875 ^@ http://purl.uniprot.org/uniprot/A0A378TE04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/39695:G6N58_RS20140 ^@ http://purl.uniprot.org/uniprot/A0A378T8S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/39695:G6N58_RS20005 ^@ http://purl.uniprot.org/uniprot/A0A378T8T3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/39695:G6N58_RS21460 ^@ http://purl.uniprot.org/uniprot/A0A378TAQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS15165 ^@ http://purl.uniprot.org/uniprot/A0A378TBM6 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS11145 ^@ http://purl.uniprot.org/uniprot/A0A378TE16 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/39695:G6N58_RS20395 ^@ http://purl.uniprot.org/uniprot/A0A378T8R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/39695:G6N58_RS29600 ^@ http://purl.uniprot.org/uniprot/A0A378TMM1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/39695:G6N58_RS08470 ^@ http://purl.uniprot.org/uniprot/A0A378TGB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrgA family.|||Cell membrane|||Involved in cell division. http://togogenome.org/gene/39695:G6N58_RS04940 ^@ http://purl.uniprot.org/uniprot/A0A378THR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS07655 ^@ http://purl.uniprot.org/uniprot/A0A378TG03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class II aldolase/RraA-like family.|||Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.|||Homotrimer. http://togogenome.org/gene/39695:G6N58_RS19685 ^@ http://purl.uniprot.org/uniprot/A0A378T913 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/39695:G6N58_RS00450 ^@ http://purl.uniprot.org/uniprot/A0A378TNI1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS04505 ^@ http://purl.uniprot.org/uniprot/A0A378THU9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/39695:G6N58_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A378TL54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/39695:G6N58_RS13905 ^@ http://purl.uniprot.org/uniprot/A0A378TCE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/39695:G6N58_RS20835 ^@ http://purl.uniprot.org/uniprot/A0A378T8H8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/39695:G6N58_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A378TJV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS22625 ^@ http://purl.uniprot.org/uniprot/A0A378T988 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/39695:G6N58_RS08395 ^@ http://purl.uniprot.org/uniprot/A0A378THD9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/39695:G6N58_RS06565 ^@ http://purl.uniprot.org/uniprot/A0A378THE5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/39695:G6N58_RS19995 ^@ http://purl.uniprot.org/uniprot/A0A378T8V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/39695:G6N58_RS12805 ^@ http://purl.uniprot.org/uniprot/A0A378TD25 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/39695:G6N58_RS00660 ^@ http://purl.uniprot.org/uniprot/A0A378TNE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/39695:G6N58_RS21715 ^@ http://purl.uniprot.org/uniprot/A0A378T910 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/39695:G6N58_RS19105 ^@ http://purl.uniprot.org/uniprot/A0A378T9Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS13295 ^@ http://purl.uniprot.org/uniprot/A0A378TCS1 ^@ Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Could possibly oxidize fatty acids using specific components. http://togogenome.org/gene/39695:G6N58_RS22790 ^@ http://purl.uniprot.org/uniprot/A0A378TA06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/39695:G6N58_RS12090 ^@ http://purl.uniprot.org/uniprot/A0A378TEB0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/39695:G6N58_RS13075 ^@ http://purl.uniprot.org/uniprot/A0A378TGH8 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/39695:G6N58_RS16345 ^@ http://purl.uniprot.org/uniprot/A0A378TAX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/39695:G6N58_RS21995 ^@ http://purl.uniprot.org/uniprot/A0A378T7Q4 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/39695:G6N58_RS14325 ^@ http://purl.uniprot.org/uniprot/A0A378TFS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS12085 ^@ http://purl.uniprot.org/uniprot/A0A378TG63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/39695:G6N58_RS19000 ^@ http://purl.uniprot.org/uniprot/A0A378T9F8 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A378THM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS19805 ^@ http://purl.uniprot.org/uniprot/A0A378T933 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/39695:G6N58_RS12880 ^@ http://purl.uniprot.org/uniprot/A0A378TGK9 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/39695:G6N58_RS08195 ^@ http://purl.uniprot.org/uniprot/A0A378TJA2 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/39695:G6N58_RS26650 ^@ http://purl.uniprot.org/uniprot/A0A378TMP7 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic ubiquitin-like protein family.|||Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.|||Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.|||The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome. http://togogenome.org/gene/39695:G6N58_RS19270 ^@ http://purl.uniprot.org/uniprot/A0A378TBY0 ^@ Function|||Similarity ^@ Belongs to the NrdI family.|||Probably involved in ribonucleotide reductase function. http://togogenome.org/gene/39695:G6N58_RS10045 ^@ http://purl.uniprot.org/uniprot/A0A378TEP0 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/39695:G6N58_RS12965 ^@ http://purl.uniprot.org/uniprot/A0A378TD36 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/39695:G6N58_RS16185 ^@ http://purl.uniprot.org/uniprot/A0A378TB18 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/39695:G6N58_RS15540 ^@ http://purl.uniprot.org/uniprot/A0A378TF52 ^@ Similarity ^@ Belongs to the UPF0336 family. http://togogenome.org/gene/39695:G6N58_RS18575 ^@ http://purl.uniprot.org/uniprot/A0A378TAN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/39695:G6N58_RS12155 ^@ http://purl.uniprot.org/uniprot/A0A378TDF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/39695:G6N58_RS09370 ^@ http://purl.uniprot.org/uniprot/A0A378TFH4 ^@ Similarity ^@ Belongs to the ThrE exporter (TC 2.A.79) family. http://togogenome.org/gene/39695:G6N58_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A378TJY0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/39695:G6N58_RS08455 ^@ http://purl.uniprot.org/uniprot/A0A378THC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CwsA family.|||Cell membrane|||Required for regulated cell division, cell wall synthesis and the maintenance of cell shape. http://togogenome.org/gene/39695:G6N58_RS25890 ^@ http://purl.uniprot.org/uniprot/A0A378TRC5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/39695:G6N58_RS14285 ^@ http://purl.uniprot.org/uniprot/A0A378TD62 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/39695:G6N58_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A378THX5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/39695:G6N58_RS11110 ^@ http://purl.uniprot.org/uniprot/A0A378TE31 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/39695:G6N58_RS11050 ^@ http://purl.uniprot.org/uniprot/A0A378TEK9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A378TLA3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/39695:G6N58_RS15575 ^@ http://purl.uniprot.org/uniprot/A0A378TC00 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/39695:G6N58_RS12840 ^@ http://purl.uniprot.org/uniprot/A0A378TDX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS15865 ^@ http://purl.uniprot.org/uniprot/A0A378TDY3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/39695:G6N58_RS14085 ^@ http://purl.uniprot.org/uniprot/A0A378TF49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/39695:G6N58_RS16365 ^@ http://purl.uniprot.org/uniprot/A0A378TDN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/39695:G6N58_RS20935 ^@ http://purl.uniprot.org/uniprot/A0A378T8F2 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/39695:G6N58_RS10840 ^@ http://purl.uniprot.org/uniprot/A0A378TE69 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/39695:G6N58_RS25895 ^@ http://purl.uniprot.org/uniprot/A0A378TQZ8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/39695:G6N58_RS00665 ^@ http://purl.uniprot.org/uniprot/A0A378TMY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/39695:G6N58_RS02725 ^@ http://purl.uniprot.org/uniprot/A0A378TM89 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/39695:G6N58_RS29620 ^@ http://purl.uniprot.org/uniprot/A0A378TKV6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/39695:G6N58_RS19610 ^@ http://purl.uniprot.org/uniprot/A0A378TCS3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS15985 ^@ http://purl.uniprot.org/uniprot/A0A378TB87 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/39695:G6N58_RS16490 ^@ http://purl.uniprot.org/uniprot/A0A378TEL1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS22665 ^@ http://purl.uniprot.org/uniprot/A0A378T7F0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/39695:G6N58_RS18725 ^@ http://purl.uniprot.org/uniprot/A0A378TAL4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/39695:G6N58_RS06440 ^@ http://purl.uniprot.org/uniprot/A0A378TH75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS12010 ^@ http://purl.uniprot.org/uniprot/A0A378TE12 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable amino-acid or metabolite transport protein. http://togogenome.org/gene/39695:G6N58_RS11860 ^@ http://purl.uniprot.org/uniprot/A0A378TE49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/39695:G6N58_RS17955 ^@ http://purl.uniprot.org/uniprot/A0A378TBY2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/39695:G6N58_RS16165 ^@ http://purl.uniprot.org/uniprot/A0A378TES8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/39695:G6N58_RS26475 ^@ http://purl.uniprot.org/uniprot/A0A378TR14 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase-binding protein RbpA family.|||Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.|||Forms a complex with the RNAP catalytic core and with free principal sigma factors.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS20520 ^@ http://purl.uniprot.org/uniprot/A0A378TBB2 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/39695:G6N58_RS20650 ^@ http://purl.uniprot.org/uniprot/A0A378TC58 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/39695:G6N58_RS16155 ^@ http://purl.uniprot.org/uniprot/A0A378TB16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/39695:G6N58_RS16860 ^@ http://purl.uniprot.org/uniprot/A0A378TB89 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS09245 ^@ http://purl.uniprot.org/uniprot/A0A378THZ1 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/39695:G6N58_RS21840 ^@ http://purl.uniprot.org/uniprot/A0A378T7X3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/39695:G6N58_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A378TIJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. R2-like ligand binding oxidase subfamily.|||Homodimer.|||Probable oxidase that might be involved in lipid metabolism. http://togogenome.org/gene/39695:G6N58_RS14420 ^@ http://purl.uniprot.org/uniprot/A0A378TDY2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cell surface|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.|||capsule|||cell wall http://togogenome.org/gene/39695:G6N58_RS08640 ^@ http://purl.uniprot.org/uniprot/A0A378TFE4 ^@ Similarity ^@ Belongs to the TmoD/XamoD family. http://togogenome.org/gene/39695:G6N58_RS09345 ^@ http://purl.uniprot.org/uniprot/A0A378THU2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable amino-acid or metabolite transport protein. http://togogenome.org/gene/39695:G6N58_RS08140 ^@ http://purl.uniprot.org/uniprot/A0A378TIJ2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/39695:G6N58_RS22600 ^@ http://purl.uniprot.org/uniprot/A0A378T7B7 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/39695:G6N58_RS10310 ^@ http://purl.uniprot.org/uniprot/A0A378TEJ2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/39695:G6N58_RS20070 ^@ http://purl.uniprot.org/uniprot/A0A378TBH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/39695:G6N58_RS20525 ^@ http://purl.uniprot.org/uniprot/A0A378T8J1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/39695:G6N58_RS09880 ^@ http://purl.uniprot.org/uniprot/A0A378TEQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/39695:G6N58_RS19915 ^@ http://purl.uniprot.org/uniprot/A0A378TAT3 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity ^@ Belongs to the GlnD family.|||Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.|||Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity. http://togogenome.org/gene/39695:G6N58_RS21875 ^@ http://purl.uniprot.org/uniprot/A0A378T7R7 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/39695:G6N58_RS20735 ^@ http://purl.uniprot.org/uniprot/A0A378T8K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/39695:G6N58_RS08330 ^@ http://purl.uniprot.org/uniprot/A0A378TFL9 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/39695:G6N58_RS05140 ^@ http://purl.uniprot.org/uniprot/A0A378THH1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/39695:G6N58_RS11515 ^@ http://purl.uniprot.org/uniprot/A0A378TDZ4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/39695:G6N58_RS22000 ^@ http://purl.uniprot.org/uniprot/A0A378T9L5 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/39695:G6N58_RS22460 ^@ http://purl.uniprot.org/uniprot/A0A378T7E7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/39695:G6N58_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A378TJX6 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/39695:G6N58_RS04590 ^@ http://purl.uniprot.org/uniprot/A0A378THS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/39695:G6N58_RS17075 ^@ http://purl.uniprot.org/uniprot/A0A378TCG4 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/39695:G6N58_RS14355 ^@ http://purl.uniprot.org/uniprot/A0A378TCN6 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/39695:G6N58_RS22420 ^@ http://purl.uniprot.org/uniprot/A0A378T7Z9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/39695:G6N58_RS11115 ^@ http://purl.uniprot.org/uniprot/A0A378TFW8 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/39695:G6N58_RS18745 ^@ http://purl.uniprot.org/uniprot/A0A378TA51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Cell membrane|||Membrane|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/39695:G6N58_RS04310 ^@ http://purl.uniprot.org/uniprot/A0A378THY4 ^@ Similarity ^@ Belongs to the nitrile hydratase subunit alpha family. http://togogenome.org/gene/39695:G6N58_RS19355 ^@ http://purl.uniprot.org/uniprot/A0A378TB42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/39695:G6N58_RS08405 ^@ http://purl.uniprot.org/uniprot/A0A378TID5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/39695:G6N58_RS17465 ^@ http://purl.uniprot.org/uniprot/A0A378TC85 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/39695:G6N58_RS07290 ^@ http://purl.uniprot.org/uniprot/A0A378TJ14 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/39695:G6N58_RS16175 ^@ http://purl.uniprot.org/uniprot/A0A378TC44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/39695:G6N58_RS17570 ^@ http://purl.uniprot.org/uniprot/A0A378TCX9 ^@ Function|||Similarity ^@ Belongs to the rubredoxin family.|||Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase. http://togogenome.org/gene/39695:G6N58_RS08425 ^@ http://purl.uniprot.org/uniprot/A0A378TFI7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.