http://togogenome.org/gene/2781774:ISP08_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A7T1B205 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1W6 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2781774:ISP08_RS10690 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9A2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS06705 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS09990 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYV7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/2781774:ISP08_RS06150 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS06830 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXS7 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/2781774:ISP08_RS06820 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXT8 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2781774:ISP08_RS04720 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1I5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/2781774:ISP08_RS06730 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/2781774:ISP08_RS08325 ^@ http://purl.uniprot.org/uniprot/A0A7T1F980 ^@ Function|||Similarity ^@ Belongs to the thioredoxin family.|||Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. http://togogenome.org/gene/2781774:ISP08_RS08075 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2781774:ISP08_RS03585 ^@ http://purl.uniprot.org/uniprot/A0A7T1B189 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1Y4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/2781774:ISP08_RS04135 ^@ http://purl.uniprot.org/uniprot/A0A7T1B254 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS06065 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAG4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/2781774:ISP08_RS11115 ^@ http://purl.uniprot.org/uniprot/A0A7T1F943 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/2781774:ISP08_RS07365 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/2781774:ISP08_RS02505 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0V0 ^@ Similarity ^@ Belongs to the TRAP family. http://togogenome.org/gene/2781774:ISP08_RS00050 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZW1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS03500 ^@ http://purl.uniprot.org/uniprot/A0A7T1B144 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS10725 ^@ http://purl.uniprot.org/uniprot/A0A7T1F920 ^@ Similarity ^@ Belongs to the UPF0741 family. http://togogenome.org/gene/2781774:ISP08_RS11860 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZK0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer.|||Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein. http://togogenome.org/gene/2781774:ISP08_RS06460 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Fur family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS03735 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAB8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.|||Belongs to the TRAP family.|||Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A7T1B159 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2781774:ISP08_RS06475 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8F3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/2781774:ISP08_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A7T1B213 ^@ Similarity ^@ Belongs to the UPF0337 (CsbD) family. http://togogenome.org/gene/2781774:ISP08_RS07935 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/2781774:ISP08_RS00825 ^@ http://purl.uniprot.org/uniprot/A0A7T1B044 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRP transporter (TC 2.A.7.5) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06905 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXT3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS07495 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY62 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/2781774:ISP08_RS08785 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily. MenH family.|||Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS09195 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ10 ^@ Similarity ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family. http://togogenome.org/gene/2781774:ISP08_RS11390 ^@ http://purl.uniprot.org/uniprot/A0A7T1B2D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/2781774:ISP08_RS03510 ^@ http://purl.uniprot.org/uniprot/A0A7T1B186 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/2781774:ISP08_RS08715 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS08140 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYN4 ^@ Function|||Similarity|||Subunit ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Homodimer and homohexamer; in equilibrium.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.|||Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. http://togogenome.org/gene/2781774:ISP08_RS07830 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS07355 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/2781774:ISP08_RS05780 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1V5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS10880 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ98 ^@ Function|||Similarity ^@ Belongs to the HPS/KGPDC family. HPS subfamily.|||Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. http://togogenome.org/gene/2781774:ISP08_RS10525 ^@ http://purl.uniprot.org/uniprot/A0A7T1F993 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS11255 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS12470 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/2781774:ISP08_RS11460 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZD9 ^@ Function|||Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/2781774:ISP08_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1Z8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/2781774:ISP08_RS07185 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS03525 ^@ http://purl.uniprot.org/uniprot/A0A7T1B149 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/2781774:ISP08_RS04325 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1D2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/2781774:ISP08_RS01705 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9Z3 ^@ Caution|||Similarity ^@ Belongs to the globin family. Two-domain flavohemoproteins subfamily.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS10600 ^@ http://purl.uniprot.org/uniprot/A0A7T1F996 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS00775 ^@ http://purl.uniprot.org/uniprot/A0A7T1B056 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/2781774:ISP08_RS04270 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1F1 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor antagonist family.|||Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B. http://togogenome.org/gene/2781774:ISP08_RS00830 ^@ http://purl.uniprot.org/uniprot/A0A7T1B088 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/2781774:ISP08_RS07015 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8G9 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/2781774:ISP08_RS03840 ^@ http://purl.uniprot.org/uniprot/A0A7T1B175 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/2781774:ISP08_RS03625 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA07 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/2781774:ISP08_RS03595 ^@ http://purl.uniprot.org/uniprot/A0A7T1B178 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/2781774:ISP08_RS04040 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1B6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/2781774:ISP08_RS11430 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/2781774:ISP08_RS08310 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYA6 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/2781774:ISP08_RS11265 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/2781774:ISP08_RS10325 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ14 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06445 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXN8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/2781774:ISP08_RS08095 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY84 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS11240 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZD3 ^@ Caution|||Function|||Similarity ^@ Belongs to the ATP:guanido phosphotransferase family.|||Catalyzes the specific phosphorylation of arginine residues in proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS06205 ^@ http://purl.uniprot.org/uniprot/A0A7T1B206 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/2781774:ISP08_RS12160 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10490 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9J4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04410 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1D6 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/2781774:ISP08_RS08780 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYW9 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS03890 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS09280 ^@ http://purl.uniprot.org/uniprot/A0A7T1F913 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily. NagD family.|||Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro. http://togogenome.org/gene/2781774:ISP08_RS10550 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ45 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/2781774:ISP08_RS06330 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXM7 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/2781774:ISP08_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1Z7 ^@ Similarity ^@ Belongs to the UPF0735 family. http://togogenome.org/gene/2781774:ISP08_RS03480 ^@ http://purl.uniprot.org/uniprot/A0A7T1B147 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS07825 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYJ1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS10590 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Fur family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS03555 ^@ http://purl.uniprot.org/uniprot/A0A7T1B157 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/2781774:ISP08_RS04350 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAF3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/2781774:ISP08_RS08255 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYA0 ^@ Similarity ^@ Belongs to the TRAP family. http://togogenome.org/gene/2781774:ISP08_RS02265 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS09890 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/2781774:ISP08_RS09425 ^@ http://purl.uniprot.org/uniprot/A0A7T1B273 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS09190 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0G9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/2781774:ISP08_RS05715 ^@ http://purl.uniprot.org/uniprot/A0A7T1B267 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/2781774:ISP08_RS11235 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZQ8 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. ClpC subfamily. http://togogenome.org/gene/2781774:ISP08_RS06305 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8G5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/2781774:ISP08_RS03630 ^@ http://purl.uniprot.org/uniprot/A0A7T1B163 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/2781774:ISP08_RS06915 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXT5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/2781774:ISP08_RS11225 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZC0 ^@ Similarity ^@ Belongs to the ycf81 family. http://togogenome.org/gene/2781774:ISP08_RS11170 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9Q2 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2781774:ISP08_RS11145 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2781774:ISP08_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A7T1B2A4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS11155 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/2781774:ISP08_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1Q5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homotetramer. http://togogenome.org/gene/2781774:ISP08_RS05845 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAD2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/2781774:ISP08_RS02185 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS06625 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/2781774:ISP08_RS07205 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PstS family.|||Cell membrane|||Involved in the system for phosphate transport across the cytoplasmic membrane.|||Membrane|||Part of the ABC transporter complex PstSACB involved in phosphate import.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/2781774:ISP08_RS06045 ^@ http://purl.uniprot.org/uniprot/A0A7T1B201 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/2781774:ISP08_RS10585 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10405 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family. YeeN subfamily.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS06395 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8F2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS01615 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0T7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10835 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ77 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/2781774:ISP08_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS04375 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein S18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS06960 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EamA transporter family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS07835 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8S2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/2781774:ISP08_RS03770 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1N4 ^@ Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. http://togogenome.org/gene/2781774:ISP08_RS07740 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/2781774:ISP08_RS08360 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8N1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/2781774:ISP08_RS09900 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ94 ^@ Function|||Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. http://togogenome.org/gene/2781774:ISP08_RS11480 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease M5 family.|||Cytoplasm|||Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. http://togogenome.org/gene/2781774:ISP08_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA32 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06170 ^@ http://purl.uniprot.org/uniprot/A0A7T1B200 ^@ Similarity ^@ Belongs to the UPF0297 family. http://togogenome.org/gene/2781774:ISP08_RS07925 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY80 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/2781774:ISP08_RS00375 ^@ http://purl.uniprot.org/uniprot/A0A7T1B058 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06835 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXU5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/2781774:ISP08_RS00320 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZZ7 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family. CrtM subfamily.|||Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid 4,4'-diapophytoene (dehydrosqualene). http://togogenome.org/gene/2781774:ISP08_RS01135 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0E6 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/2781774:ISP08_RS10020 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/2781774:ISP08_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A7T1B143 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/2781774:ISP08_RS04820 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1J8 ^@ Similarity ^@ Belongs to the UPF0421 family. http://togogenome.org/gene/2781774:ISP08_RS12680 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS08705 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS08600 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8P5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. http://togogenome.org/gene/2781774:ISP08_RS11230 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZC2 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/2781774:ISP08_RS09175 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS10115 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9H0 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/2781774:ISP08_RS03155 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0Z9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS09340 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYP7 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/2781774:ISP08_RS11810 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZM7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/2781774:ISP08_RS06990 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/2781774:ISP08_RS07990 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8T3 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/2781774:ISP08_RS04685 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/2781774:ISP08_RS09345 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS08210 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA34 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/2781774:ISP08_RS07985 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY66 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/2781774:ISP08_RS06175 ^@ http://purl.uniprot.org/uniprot/A0A7T1B2B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9L9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2781774:ISP08_RS07425 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY00 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS02275 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0Q5 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/2781774:ISP08_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/2781774:ISP08_RS06595 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8U9 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/2781774:ISP08_RS03850 ^@ http://purl.uniprot.org/uniprot/A0A7T1B180 ^@ Function|||Subunit ^@ Homodimer or homotrimer. Seems to be a monomer when not phosphorylated.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. http://togogenome.org/gene/2781774:ISP08_RS05595 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1S2 ^@ Function ^@ Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. http://togogenome.org/gene/2781774:ISP08_RS03260 ^@ http://purl.uniprot.org/uniprot/A0A7T1B115 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS03105 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0Z1 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2781774:ISP08_RS10790 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS09980 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYW8 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/2781774:ISP08_RS07965 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/2781774:ISP08_RS08170 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYA5 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/2781774:ISP08_RS11440 ^@ http://purl.uniprot.org/uniprot/A0A7T1F959 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/2781774:ISP08_RS07465 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY04 ^@ Similarity|||Subunit ^@ Belongs to the catalase family.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS03520 ^@ http://purl.uniprot.org/uniprot/A0A7T1B169 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/2781774:ISP08_RS07905 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY56 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/2781774:ISP08_RS11820 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.|||Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.|||Cytoplasm|||Homodimer.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/2781774:ISP08_RS05905 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1W2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/2781774:ISP08_RS03350 ^@ http://purl.uniprot.org/uniprot/A0A7T1B124 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/2781774:ISP08_RS09880 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8X1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/2781774:ISP08_RS09120 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS08865 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS08975 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.|||Belongs to the SpxH family.|||Cytoplasm|||Interacts with Spx. http://togogenome.org/gene/2781774:ISP08_RS08595 ^@ http://purl.uniprot.org/uniprot/A0A7T1F964 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/2781774:ISP08_RS09300 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYL0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS11260 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/2781774:ISP08_RS08230 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8V3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/2781774:ISP08_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A7T1B150 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/2781774:ISP08_RS03550 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS06810 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXS5 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/2781774:ISP08_RS00930 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9I7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS10110 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8X8 ^@ Function|||Similarity ^@ Belongs to the NrdI family.|||Probably involved in ribonucleotide reductase function. http://togogenome.org/gene/2781774:ISP08_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS08080 ^@ http://purl.uniprot.org/uniprot/A0A7T1F961 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/2781774:ISP08_RS08430 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYC3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Interacts with CtaA.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS07350 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10715 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ63 ^@ Similarity|||Subunit ^@ Belongs to the azoreductase type 2 family.|||Homotetramer. http://togogenome.org/gene/2781774:ISP08_RS11690 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IcaD family.|||Cell membrane|||Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Is required for full IcaA N-acetylglucosaminyltransferase activity. http://togogenome.org/gene/2781774:ISP08_RS02280 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS05105 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAQ8 ^@ Similarity ^@ Belongs to the UPF0342 family. http://togogenome.org/gene/2781774:ISP08_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A7T1B223 ^@ Function|||Similarity ^@ Belongs to the NanE family.|||Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). http://togogenome.org/gene/2781774:ISP08_RS07485 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8I8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS05790 ^@ http://purl.uniprot.org/uniprot/A0A7T1B281 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS08950 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYL5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS11455 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZI6 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/2781774:ISP08_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8R8 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/2781774:ISP08_RS08015 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY69 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/2781774:ISP08_RS06275 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/2781774:ISP08_RS03495 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/2781774:ISP08_RS06590 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXP5 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/2781774:ISP08_RS07810 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA31 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/2781774:ISP08_RS07820 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/2781774:ISP08_RS08940 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8R2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04100 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS11385 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZE7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/2781774:ISP08_RS02140 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/2781774:ISP08_RS06725 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Fur family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS04655 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1H4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/2781774:ISP08_RS10530 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ68 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/2781774:ISP08_RS09955 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9F4 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/2781774:ISP08_RS06465 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8G8 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/2781774:ISP08_RS08220 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsL family.|||Cell membrane|||Essential cell division protein.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10645 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9K8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/2781774:ISP08_RS03215 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAG9 ^@ Function ^@ Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer. http://togogenome.org/gene/2781774:ISP08_RS02870 ^@ http://purl.uniprot.org/uniprot/A0A7T1B177 ^@ Function ^@ Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer. http://togogenome.org/gene/2781774:ISP08_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS09050 ^@ http://purl.uniprot.org/uniprot/A0A7T1F900 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/2781774:ISP08_RS02745 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0W0 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/2781774:ISP08_RS03620 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/2781774:ISP08_RS09455 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS07910 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/2781774:ISP08_RS03750 ^@ http://purl.uniprot.org/uniprot/A0A7T1B192 ^@ Similarity ^@ Belongs to the UDPGP type 1 family. http://togogenome.org/gene/2781774:ISP08_RS02045 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10210 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ00 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS11220 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZH0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS01260 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2781774:ISP08_RS12480 ^@ http://purl.uniprot.org/uniprot/A0A7T1B065 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/2781774:ISP08_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS05065 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAI5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/2781774:ISP08_RS04810 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1J3 ^@ Similarity ^@ Belongs to the UPF0374 family. http://togogenome.org/gene/2781774:ISP08_RS00085 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZW6 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/2781774:ISP08_RS09235 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYM3 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/2781774:ISP08_RS03185 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0Z8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS02670 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS09870 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS07920 ^@ http://purl.uniprot.org/uniprot/A0A7T1F949 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/2781774:ISP08_RS03600 ^@ http://purl.uniprot.org/uniprot/A0A7T1B154 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS08205 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS08000 ^@ http://purl.uniprot.org/uniprot/A0A7T1F956 ^@ Function|||Similarity ^@ Belongs to the asp23 family.|||May play a key role in alkaline pH tolerance. http://togogenome.org/gene/2781774:ISP08_RS03960 ^@ http://purl.uniprot.org/uniprot/A0A7T1B199 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/2781774:ISP08_RS04010 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1E4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/2781774:ISP08_RS10125 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10580 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06600 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXQ0 ^@ Function|||Similarity ^@ Belongs to the asp23 family.|||May play a key role in alkaline pH tolerance. http://togogenome.org/gene/2781774:ISP08_RS04330 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1G0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/2781774:ISP08_RS09860 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS06770 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8H9 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2781774:ISP08_RS00010 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase. http://togogenome.org/gene/2781774:ISP08_RS04250 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1G4 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/2781774:ISP08_RS05785 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1U5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS04075 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1M0 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/2781774:ISP08_RS02260 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA22 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2781774:ISP08_RS03490 ^@ http://purl.uniprot.org/uniprot/A0A7T1B135 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS03295 ^@ http://purl.uniprot.org/uniprot/A0A7T1B125 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9T5 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/2781774:ISP08_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/2781774:ISP08_RS06765 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.|||Cell membrane|||Membrane|||Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. http://togogenome.org/gene/2781774:ISP08_RS10985 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS08175 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/2781774:ISP08_RS09945 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYV9 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/2781774:ISP08_RS06080 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1Y5 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. http://togogenome.org/gene/2781774:ISP08_RS03950 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1A4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/2781774:ISP08_RS09930 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2781774:ISP08_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A7T1B204 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS03615 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/2781774:ISP08_RS03165 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS10425 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ66 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/2781774:ISP08_RS11560 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/2781774:ISP08_RS04745 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAH7 ^@ Similarity ^@ Belongs to the UPF0435 family. http://togogenome.org/gene/2781774:ISP08_RS09335 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYT2 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/2781774:ISP08_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1F2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2781774:ISP08_RS07135 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXW1 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/2781774:ISP08_RS03265 ^@ http://purl.uniprot.org/uniprot/A0A7T1B109 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS05750 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1U4 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/2781774:ISP08_RS07680 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS08800 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/2781774:ISP08_RS07245 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FemABX family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS09385 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYN6 ^@ Similarity ^@ Belongs to the nitroreductase family. http://togogenome.org/gene/2781774:ISP08_RS03515 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAJ6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/2781774:ISP08_RS11180 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/2781774:ISP08_RS04465 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/2781774:ISP08_RS04095 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAN0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1D1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.|||Homohexamer; trimer of homodimers. http://togogenome.org/gene/2781774:ISP08_RS03530 ^@ http://purl.uniprot.org/uniprot/A0A7T1B142 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS09135 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9C7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/2781774:ISP08_RS04090 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS03910 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1B7 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/2781774:ISP08_RS02330 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0N7 ^@ Caution|||Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.|||Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS03845 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1I4 ^@ Similarity ^@ Belongs to the mannitol dehydrogenase family. http://togogenome.org/gene/2781774:ISP08_RS11160 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9D4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2781774:ISP08_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.|||Probably involved in cell-wall metabolism.|||Secreted http://togogenome.org/gene/2781774:ISP08_RS11175 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZC7 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/2781774:ISP08_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS01885 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS08300 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYA2 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/2781774:ISP08_RS11125 ^@ http://purl.uniprot.org/uniprot/A0A7T1F948 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/2781774:ISP08_RS08565 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYF3 ^@ Function|||Similarity|||Subunit ^@ A non-essential component of RNA polymerase (RNAP).|||Belongs to the RNA polymerase subunit epsilon family.|||RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2781774:ISP08_RS03535 ^@ http://purl.uniprot.org/uniprot/A0A7T1B155 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/2781774:ISP08_RS07690 ^@ http://purl.uniprot.org/uniprot/A0A7T1F935 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane|||This protein catalyzes the committed step to the synthesis of the acidic phospholipids. http://togogenome.org/gene/2781774:ISP08_RS10100 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYY5 ^@ Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/2781774:ISP08_RS09185 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06605 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXR3 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/2781774:ISP08_RS07390 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXZ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAW1 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/2781774:ISP08_RS07040 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXU8 ^@ Similarity ^@ Belongs to the UPF0346 family. http://togogenome.org/gene/2781774:ISP08_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A7T1B230 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/2781774:ISP08_RS06355 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8T7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/2781774:ISP08_RS01960 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0L7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/2781774:ISP08_RS07430 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0291 family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS07420 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0154 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXP0 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/2781774:ISP08_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAB3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. RocA subfamily. http://togogenome.org/gene/2781774:ISP08_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY61 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/2781774:ISP08_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1X7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/2781774:ISP08_RS08190 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8N5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/2781774:ISP08_RS10340 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9I8 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/2781774:ISP08_RS08450 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYI4 ^@ Similarity ^@ Belongs to the UPF0358 family. http://togogenome.org/gene/2781774:ISP08_RS10385 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9K1 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2781774:ISP08_RS06940 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXY2 ^@ Similarity ^@ Belongs to the UPF0398 family. http://togogenome.org/gene/2781774:ISP08_RS11205 ^@ http://purl.uniprot.org/uniprot/A0A7T1B295 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/2781774:ISP08_RS00325 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZY6 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/2781774:ISP08_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0N8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/2781774:ISP08_RS08675 ^@ http://purl.uniprot.org/uniprot/A0A7T1F970 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/2781774:ISP08_RS06800 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS05730 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1X2 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2781774:ISP08_RS06945 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXS8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS09170 ^@ http://purl.uniprot.org/uniprot/A0A7T1F998 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS12810 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZX9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/2781774:ISP08_RS07855 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/2781774:ISP08_RS10595 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS12475 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZR9 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/2781774:ISP08_RS08930 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8R9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/2781774:ISP08_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS06675 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS02335 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA25 ^@ Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Catalyzes the NADPH dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate. http://togogenome.org/gene/2781774:ISP08_RS08995 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYJ2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the MecA family.|||Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.|||Homodimer.|||The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. http://togogenome.org/gene/2781774:ISP08_RS03605 ^@ http://purl.uniprot.org/uniprot/A0A7T1B162 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/2781774:ISP08_RS05675 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1V7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2781774:ISP08_RS09000 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArsC family. Spx subfamily.|||Cytoplasm|||Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.|||Interacts with the C-terminal domain of the alpha subunit of the RNAP. http://togogenome.org/gene/2781774:ISP08_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/2781774:ISP08_RS05875 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1W4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/2781774:ISP08_RS11400 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZE0 ^@ Function ^@ Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/2781774:ISP08_RS07605 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY24 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).|||Belongs to the FGGY kinase family.|||Homotetramer and homodimer (in equilibrium).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme. http://togogenome.org/gene/2781774:ISP08_RS06380 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/2781774:ISP08_RS02890 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0Z6 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/2781774:ISP08_RS00125 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9Z0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS00065 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9Z1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/2781774:ISP08_RS11510 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the YabA family.|||Interacts with both DnaA and DnaN, acting as a bridge between these two proteins.|||Involved in initiation control of chromosome replication. http://togogenome.org/gene/2781774:ISP08_RS10970 ^@ http://purl.uniprot.org/uniprot/A0A7T1F936 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2781774:ISP08_RS03505 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/2781774:ISP08_RS03115 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1A2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS06840 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/2781774:ISP08_RS02050 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0J0 ^@ Similarity ^@ Belongs to the ThrE exporter (TC 2.A.79) family. http://togogenome.org/gene/2781774:ISP08_RS07675 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY22 ^@ Function|||Similarity ^@ Belongs to the RNase Y family.|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/2781774:ISP08_RS02655 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0X3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/2781774:ISP08_RS05580 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0478 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS11120 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS00365 ^@ http://purl.uniprot.org/uniprot/A0A7T1B004 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/2781774:ISP08_RS04595 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS09950 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/2781774:ISP08_RS03690 ^@ http://purl.uniprot.org/uniprot/A0A7T1B174 ^@ Function|||Similarity ^@ Belongs to the asp23 family.|||May play a key role in alkaline pH tolerance. http://togogenome.org/gene/2781774:ISP08_RS12630 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9X9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS07950 ^@ http://purl.uniprot.org/uniprot/A0A7T1F922 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS07340 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS04440 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1I6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AgrB family.|||Cell membrane|||Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP. http://togogenome.org/gene/2781774:ISP08_RS10535 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS10945 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZA9 ^@ Similarity ^@ Belongs to the 4-oxalocrotonate tautomerase family. http://togogenome.org/gene/2781774:ISP08_RS05695 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS12785 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZU7 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/2781774:ISP08_RS08790 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8Y7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS09320 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8U0 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/2781774:ISP08_RS12675 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS10920 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ84 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/2781774:ISP08_RS12230 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZM9 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/2781774:ISP08_RS11130 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/2781774:ISP08_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/2781774:ISP08_RS09960 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8X7 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS05355 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1S0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. http://togogenome.org/gene/2781774:ISP08_RS00725 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9T3 ^@ Similarity ^@ Belongs to the alpha-acetolactate decarboxylase family. http://togogenome.org/gene/2781774:ISP08_RS07560 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8K3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutamine synthetase family.|||Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.|||Oligomer of 12 subunits arranged in the form of two hexagons. In its feedback-inhibited form, interacts with TnrA in order to block its DNA-binding activity. http://togogenome.org/gene/2781774:ISP08_RS03040 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA68 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS08880 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. http://togogenome.org/gene/2781774:ISP08_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/2781774:ISP08_RS00080 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZW2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/2781774:ISP08_RS10220 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS09005 ^@ http://purl.uniprot.org/uniprot/A0A7T1B256 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS07500 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS08370 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYH5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2781774:ISP08_RS07730 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8K2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/2781774:ISP08_RS08905 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9B3 ^@ Similarity ^@ Belongs to the 2H phosphoesterase superfamily. YjcG family. http://togogenome.org/gene/2781774:ISP08_RS10090 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS11375 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZI0 ^@ Similarity|||Subunit ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A7T1B215 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2781774:ISP08_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS03765 ^@ http://purl.uniprot.org/uniprot/A0A7T1B183 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the multidrug resistance efflux pump SepA family.|||Cell membrane|||Involved in multidrug efflux. http://togogenome.org/gene/2781774:ISP08_RS00945 ^@ http://purl.uniprot.org/uniprot/A0A7T1B078 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the staphylococcal hemolytic protein family.|||Secreted http://togogenome.org/gene/2781774:ISP08_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZY4 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/2781774:ISP08_RS07645 ^@ http://purl.uniprot.org/uniprot/A0A7T1F901 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/2781774:ISP08_RS03325 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9Y1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/2781774:ISP08_RS07840 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CodY family.|||Cytoplasm|||DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor. http://togogenome.org/gene/2781774:ISP08_RS06365 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXM8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/2781774:ISP08_RS07320 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8Y2 ^@ Similarity ^@ Belongs to the 4-oxalocrotonate tautomerase family. http://togogenome.org/gene/2781774:ISP08_RS06310 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/2781774:ISP08_RS03580 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAA7 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2781774:ISP08_RS04110 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/2781774:ISP08_RS09855 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/2781774:ISP08_RS09155 ^@ http://purl.uniprot.org/uniprot/A0A7T1B2D3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/2781774:ISP08_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A7T1AXX1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS07790 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/2781774:ISP08_RS09150 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYK7 ^@ Function ^@ Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/2781774:ISP08_RS07615 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY36 ^@ Function ^@ Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA. http://togogenome.org/gene/2781774:ISP08_RS12805 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9D3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/2781774:ISP08_RS07755 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/2781774:ISP08_RS07490 ^@ http://purl.uniprot.org/uniprot/A0A7T1B275 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/2781774:ISP08_RS10925 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9C1 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/2781774:ISP08_RS09375 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYP6 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/2781774:ISP08_RS11450 ^@ http://purl.uniprot.org/uniprot/A0A7T1F958 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/2781774:ISP08_RS10140 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZB9 ^@ Function|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. http://togogenome.org/gene/2781774:ISP08_RS09395 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8U4 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/2781774:ISP08_RS10830 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZ80 ^@ Similarity ^@ Belongs to the ThiD family. http://togogenome.org/gene/2781774:ISP08_RS11555 ^@ http://purl.uniprot.org/uniprot/A0A7T1F963 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/2781774:ISP08_RS03940 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS04035 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1B9 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2781774:ISP08_RS11635 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9R3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/2781774:ISP08_RS07850 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY59 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/2781774:ISP08_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAT9 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2781774:ISP08_RS09140 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.|||Catalyzes the interconversion of ornithine to glutamate semialdehyde.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS06440 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. CshB subfamily.|||Cytoplasm|||Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. http://togogenome.org/gene/2781774:ISP08_RS08005 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY82 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/2781774:ISP08_RS00165 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.|||Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS04260 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1F8 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/2781774:ISP08_RS04740 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1J1 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/2781774:ISP08_RS04610 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1K4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.|||Homodimer and homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/2781774:ISP08_RS00605 ^@ http://purl.uniprot.org/uniprot/A0A7T1B035 ^@ Similarity ^@ Belongs to the alpha-acetolactate decarboxylase family. http://togogenome.org/gene/2781774:ISP08_RS01965 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0M3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS05880 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAM4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/2781774:ISP08_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A7T1B164 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/2781774:ISP08_RS06200 ^@ http://purl.uniprot.org/uniprot/A0A7T1B217 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS07815 ^@ http://purl.uniprot.org/uniprot/A0A7T1AY64 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/2781774:ISP08_RS06040 ^@ http://purl.uniprot.org/uniprot/A0A7T1FAV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/2781774:ISP08_RS10235 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family.|||Membrane http://togogenome.org/gene/2781774:ISP08_RS08465 ^@ http://purl.uniprot.org/uniprot/A0A7T1AYS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS03145 ^@ http://purl.uniprot.org/uniprot/A0A7T1B102 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/2781774:ISP08_RS03100 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0Z7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide. http://togogenome.org/gene/2781774:ISP08_RS11610 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZG7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2781774:ISP08_RS01880 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0L6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS05830 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1X4 ^@ Similarity|||Subunit ^@ Belongs to the FPG family.|||Monomer. http://togogenome.org/gene/2781774:ISP08_RS03570 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1F4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/2781774:ISP08_RS12635 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9C5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2781774:ISP08_RS06470 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8S3 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/2781774:ISP08_RS08720 ^@ http://purl.uniprot.org/uniprot/A0A7T1F9A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase bacterial subunit 4 family.|||Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.|||Cell membrane|||Membrane http://togogenome.org/gene/2781774:ISP08_RS11165 ^@ http://purl.uniprot.org/uniprot/A0A7T1AZE9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/2781774:ISP08_RS11215 ^@ http://purl.uniprot.org/uniprot/A0A7T1B266 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/2781774:ISP08_RS02160 ^@ http://purl.uniprot.org/uniprot/A0A7T1B0K5 ^@ Function|||Subcellular Location Annotation ^@ Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS00380 ^@ http://purl.uniprot.org/uniprot/A0A7T1FA05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.|||Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].|||Cytoplasm http://togogenome.org/gene/2781774:ISP08_RS02970 ^@ http://purl.uniprot.org/uniprot/A0A7T1B106 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. HrtA family.|||Cell membrane|||Membrane|||Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (HrtA), two transmembrane proteins (HrtB) and a solute-binding protein. http://togogenome.org/gene/2781774:ISP08_RS03045 ^@ http://purl.uniprot.org/uniprot/A0A7T1B118 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.|||Catalyzes the sodium-dependent transport of glutamate.|||Cell membrane http://togogenome.org/gene/2781774:ISP08_RS07005 ^@ http://purl.uniprot.org/uniprot/A0A7T1F8I4 ^@ Similarity ^@ Belongs to the UPF0403 family. http://togogenome.org/gene/2781774:ISP08_RS04645 ^@ http://purl.uniprot.org/uniprot/A0A7T1B1H1 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits.