http://togogenome.org/gene/2749961:BHS00_RS05155 ^@ http://purl.uniprot.org/uniprot/A0A7L4W934 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/2749961:BHS00_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A7L4W689 ^@ Function ^@ Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. http://togogenome.org/gene/2749961:BHS00_RS09325 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/2749961:BHS00_RS07855 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7U4 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/2749961:BHS00_RS07050 ^@ http://purl.uniprot.org/uniprot/A0A7L4W805 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per trimer. http://togogenome.org/gene/2749961:BHS00_RS04320 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/2749961:BHS00_RS03175 ^@ http://purl.uniprot.org/uniprot/A0A7L4WCH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/2749961:BHS00_RS03430 ^@ http://purl.uniprot.org/uniprot/A0A7L4W700 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2749961:BHS00_RS09415 ^@ http://purl.uniprot.org/uniprot/A0A7L4W955 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/2749961:BHS00_RS09750 ^@ http://purl.uniprot.org/uniprot/A0A7L4WCG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS00260 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6T8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/2749961:BHS00_RS00630 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5A8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/2749961:BHS00_RS09410 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8M0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/2749961:BHS00_RS08880 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8W9 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/2749961:BHS00_RS05140 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6I6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/2749961:BHS00_RS09270 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/2749961:BHS00_RS08900 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB19 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/2749961:BHS00_RS01530 ^@ http://purl.uniprot.org/uniprot/A0A7L4W798 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/2749961:BHS00_RS03395 ^@ http://purl.uniprot.org/uniprot/A0A7L4W665 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/2749961:BHS00_RS06695 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/2749961:BHS00_RS07430 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAW0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2749961:BHS00_RS09310 ^@ http://purl.uniprot.org/uniprot/A0A7L4W936 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/2749961:BHS00_RS07580 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/2749961:BHS00_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A7L4W656 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS06705 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9X4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/2749961:BHS00_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A7L4W706 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/2749961:BHS00_RS09375 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/2749961:BHS00_RS08860 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9Q8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/2749961:BHS00_RS02490 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6M7 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/2749961:BHS00_RS06630 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7S6 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS09390 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9Z5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS04305 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6L7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS07485 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS05145 ^@ http://purl.uniprot.org/uniprot/A0A7L4W712 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2749961:BHS00_RS01135 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5G8 ^@ Similarity ^@ Belongs to the UPF0223 family. http://togogenome.org/gene/2749961:BHS00_RS07560 ^@ http://purl.uniprot.org/uniprot/A0A7L4W897 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a set of proteins in which some residues (ACT_SITE, NP_BIND, REGION and BINDING) are not conserved. http://togogenome.org/gene/2749961:BHS00_RS06780 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7T2 ^@ Similarity|||Subunit ^@ Belongs to the UPF0210 family.|||Homodimer. http://togogenome.org/gene/2749961:BHS00_RS02920 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7Y4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/2749961:BHS00_RS00255 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7T3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/2749961:BHS00_RS05455 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm http://togogenome.org/gene/2749961:BHS00_RS00510 ^@ http://purl.uniprot.org/uniprot/A0A7L4W4X8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/2749961:BHS00_RS07635 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBD0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/2749961:BHS00_RS00035 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAK6 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/2749961:BHS00_RS02770 ^@ http://purl.uniprot.org/uniprot/A0A7L4W808 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS02335 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5I6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS09350 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8R5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2749961:BHS00_RS09755 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS09395 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBU6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/2749961:BHS00_RS06710 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8N5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2749961:BHS00_RS04820 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8X7 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/2749961:BHS00_RS02945 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5R1 ^@ Caution|||Function|||Similarity ^@ Belongs to the NrdR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/2749961:BHS00_RS06580 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9T8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/2749961:BHS00_RS08390 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBB7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2749961:BHS00_RS02135 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7Q0 ^@ Similarity ^@ Belongs to the UPF0346 family. http://togogenome.org/gene/2749961:BHS00_RS03010 ^@ http://purl.uniprot.org/uniprot/A0A7L4W662 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/2749961:BHS00_RS09425 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/2749961:BHS00_RS09380 ^@ http://purl.uniprot.org/uniprot/A0A7L4WC88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9P9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2749961:BHS00_RS07675 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAD7 ^@ Similarity ^@ Belongs to the 4-oxalocrotonate tautomerase family. http://togogenome.org/gene/2749961:BHS00_RS02425 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7U8 ^@ Similarity ^@ Belongs to the CtsR family. http://togogenome.org/gene/2749961:BHS00_RS01100 ^@ http://purl.uniprot.org/uniprot/A0A7L4W644 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/2749961:BHS00_RS07545 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7T7 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/2749961:BHS00_RS00795 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6U9 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2749961:BHS00_RS07225 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9Z7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2749961:BHS00_RS06835 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7C4 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/2749961:BHS00_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A7L4WC34 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/2749961:BHS00_RS09300 ^@ http://purl.uniprot.org/uniprot/A0A7L4W931 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/2749961:BHS00_RS03950 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/2749961:BHS00_RS01095 ^@ http://purl.uniprot.org/uniprot/A0A7L4W778 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/2749961:BHS00_RS07720 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS09405 ^@ http://purl.uniprot.org/uniprot/A0A7L4W951 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/2749961:BHS00_RS09385 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/2749961:BHS00_RS04275 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8R3 ^@ Similarity ^@ Belongs to the thioester dehydratase family. FabZ subfamily. http://togogenome.org/gene/2749961:BHS00_RS06675 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/2749961:BHS00_RS09345 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBT4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A7L4W865 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/2749961:BHS00_RS07565 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAB7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2749961:BHS00_RS07600 ^@ http://purl.uniprot.org/uniprot/A0A7L4W891 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. http://togogenome.org/gene/2749961:BHS00_RS02310 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7S9 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/2749961:BHS00_RS07715 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7S3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS02115 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5U4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2749961:BHS00_RS07360 ^@ http://purl.uniprot.org/uniprot/A0A7L4WA54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:citrate (SCF) symporter family.|||Cell membrane http://togogenome.org/gene/2749961:BHS00_RS09800 ^@ http://purl.uniprot.org/uniprot/A0A7L4WC82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A7L4W701 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/2749961:BHS00_RS09315 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB87 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/2749961:BHS00_RS01970 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7G8 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/2749961:BHS00_RS05410 ^@ http://purl.uniprot.org/uniprot/A0A7L4W761 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/2749961:BHS00_RS04750 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6U5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.|||Belongs to the DltC family.|||Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.|||Cytoplasm http://togogenome.org/gene/2749961:BHS00_RS02420 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8S7 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/2749961:BHS00_RS09455 ^@ http://purl.uniprot.org/uniprot/A0A7L4W962 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/2749961:BHS00_RS09400 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8R7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS09370 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB98 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2749961:BHS00_RS08385 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9G8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/2749961:BHS00_RS05195 ^@ http://purl.uniprot.org/uniprot/A0A7L4W721 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0154 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS05355 ^@ http://purl.uniprot.org/uniprot/A0A7L4W752 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/2749961:BHS00_RS06455 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/2749961:BHS00_RS09960 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family. YeeN subfamily.|||Cytoplasm http://togogenome.org/gene/2749961:BHS00_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/2749961:BHS00_RS07540 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAY0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2749961:BHS00_RS09720 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8Y0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2749961:BHS00_RS08790 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAT7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/2749961:BHS00_RS04260 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8P8 ^@ Similarity ^@ Belongs to the thioester dehydratase family. FabZ subfamily. http://togogenome.org/gene/2749961:BHS00_RS03450 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/2749961:BHS00_RS02190 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6J2 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2749961:BHS00_RS07780 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/2749961:BHS00_RS02800 ^@ http://purl.uniprot.org/uniprot/A0A7L4W603 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/2749961:BHS00_RS07615 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2749961:BHS00_RS02925 ^@ http://purl.uniprot.org/uniprot/A0A7L4W916 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/2749961:BHS00_RS09265 ^@ http://purl.uniprot.org/uniprot/A0A7L4WB75 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2749961:BHS00_RS01315 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HPr family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.|||P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity. http://togogenome.org/gene/2749961:BHS00_RS02670 ^@ http://purl.uniprot.org/uniprot/A0A7L4WCX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein S18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/2749961:BHS00_RS06840 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/2749961:BHS00_RS09365 ^@ http://purl.uniprot.org/uniprot/A0A7L4W945 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/2749961:BHS00_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A7L4W985 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/2749961:BHS00_RS09440 ^@ http://purl.uniprot.org/uniprot/A0A7L4WA06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A7L4WA02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/2749961:BHS00_RS08785 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAZ8 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/2749961:BHS00_RS07480 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAX0 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/2749961:BHS00_RS07665 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7R3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/2749961:BHS00_RS07590 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS00450 ^@ http://purl.uniprot.org/uniprot/A0A7L4W579 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/2749961:BHS00_RS02195 ^@ http://purl.uniprot.org/uniprot/A0A7L4W806 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/2749961:BHS00_RS01130 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArsC family. Spx subfamily.|||Cytoplasm|||Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.|||Interacts with the C-terminal domain of the alpha subunit of the RNAP. http://togogenome.org/gene/2749961:BHS00_RS07005 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9Z6 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2749961:BHS00_RS05885 ^@ http://purl.uniprot.org/uniprot/A0A7L4W9X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/2749961:BHS00_RS01110 ^@ http://purl.uniprot.org/uniprot/A0A7L4W532 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/2749961:BHS00_RS06315 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7L6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/2749961:BHS00_RS00775 ^@ http://purl.uniprot.org/uniprot/A0A7L4W4Z9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/2749961:BHS00_RS02650 ^@ http://purl.uniprot.org/uniprot/A0A7L4W6P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/2749961:BHS00_RS09915 ^@ http://purl.uniprot.org/uniprot/A0A7L4WCJ1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/2749961:BHS00_RS01930 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/2749961:BHS00_RS00960 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5E9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArsC family. Spx subfamily.|||Cytoplasm|||Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.|||Interacts with the C-terminal domain of the alpha subunit of the RNAP. http://togogenome.org/gene/2749961:BHS00_RS09420 ^@ http://purl.uniprot.org/uniprot/A0A7L4WBB0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/2749961:BHS00_RS01955 ^@ http://purl.uniprot.org/uniprot/A0A7L4W5D8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2749961:BHS00_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A7L4W697 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2749961:BHS00_RS07670 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8B7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS09430 ^@ http://purl.uniprot.org/uniprot/A0A7L4WC99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2749961:BHS00_RS01495 ^@ http://purl.uniprot.org/uniprot/A0A7L4W7N3 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/2749961:BHS00_RS06275 ^@ http://purl.uniprot.org/uniprot/A0A7L4WAP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/2749961:BHS00_RS08500 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8B3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/2749961:BHS00_RS04370 ^@ http://purl.uniprot.org/uniprot/A0A7L4W8P4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.