http://togogenome.org/gene/273075:TA_RS00465 ^@ http://purl.uniprot.org/uniprot/Q9HLY2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/273075:TA_RS03155 ^@ http://purl.uniprot.org/uniprot/P28061 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The configuration of the closed gate contains an opening large enough to allow rapid entry of tetrapeptides but able to impede the entry of proteins and longer peptides.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/273075:TA_RS03545 ^@ http://purl.uniprot.org/uniprot/Q9HKB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS04765 ^@ http://purl.uniprot.org/uniprot/Q9HJP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeosine synthase type 1 family.|||Forms a robust complex with the archaeosine synthase beta subunit RaSEA, likely an alpha(2)beta(2) heterotetrameric structure. Formation of this complex highly increases lysine transfer activity.|||Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine. http://togogenome.org/gene/273075:TA_RS05900 ^@ http://purl.uniprot.org/uniprot/Q9HJ34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer. http://togogenome.org/gene/273075:TA_RS01070 ^@ http://purl.uniprot.org/uniprot/Q9HLL5 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/273075:TA_RS00550 ^@ http://purl.uniprot.org/uniprot/Q9HLW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/273075:TA_RS00500 ^@ http://purl.uniprot.org/uniprot/Q9HLX6 ^@ Caution|||Similarity ^@ Belongs to the peptidase S16 family.|||Lacks the conserved Ser-Lys catalytic dyad essential for proteolytic activity. Its enzyme activity is therefore unsure. http://togogenome.org/gene/273075:TA_RS00870 ^@ http://purl.uniprot.org/uniprot/Q9HLQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/273075:TA_RS02665 ^@ http://purl.uniprot.org/uniprot/Q9HKT1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LplA family.|||Cytoplasm|||Heterodimer composed of LplA and LplB.|||In contrast to E.coli, where the lipoate-protein ligase is encoded by a single gene product (LplA) with a large N-terminal domain and a small C-terminal domain, the same activity in T.acidophilum is dependent on two separate proteins, corresponding to the two domains of E.coli LplA, respectively.|||Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate. http://togogenome.org/gene/273075:TA_RS06425 ^@ http://purl.uniprot.org/uniprot/Q9HIT4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/273075:TA_RS00010 ^@ http://purl.uniprot.org/uniprot/Q9HM68 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/273075:TA_RS00390 ^@ http://purl.uniprot.org/uniprot/Q9HLZ8 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). http://togogenome.org/gene/273075:TA_RS04460 ^@ http://purl.uniprot.org/uniprot/Q9HJU9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/273075:TA_RS03550 ^@ http://purl.uniprot.org/uniprot/Q9HKB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273075:TA_RS04070 ^@ http://purl.uniprot.org/uniprot/Q9HK17 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/273075:TA_RS06730 ^@ http://purl.uniprot.org/uniprot/P60466 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity). http://togogenome.org/gene/273075:TA_RS05510 ^@ http://purl.uniprot.org/uniprot/Q9HJA6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/273075:TA_RS03925 ^@ http://purl.uniprot.org/uniprot/Q9HK42 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/273075:TA_RS05060 ^@ http://purl.uniprot.org/uniprot/P48424 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms a Heterooligomeric complex of two stacked eight-membered rings.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.|||The N-terminus is blocked. http://togogenome.org/gene/273075:TA_RS00750 ^@ http://purl.uniprot.org/uniprot/Q9HLS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS04200 ^@ http://purl.uniprot.org/uniprot/O93655 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Part of the tricorn proteolytic complex.|||Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids. http://togogenome.org/gene/273075:TA_RS01225 ^@ http://purl.uniprot.org/uniprot/Q9HLJ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS04120 ^@ http://purl.uniprot.org/uniprot/Q9HK10 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/273075:TA_RS01855 ^@ http://purl.uniprot.org/uniprot/P57692 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/273075:TA_RS02350 ^@ http://purl.uniprot.org/uniprot/Q9HKZ3 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/273075:TA_RS05440 ^@ http://purl.uniprot.org/uniprot/Q9HJB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273075:TA_RS05695 ^@ http://purl.uniprot.org/uniprot/Q9HJ72 ^@ Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN. http://togogenome.org/gene/273075:TA_RS06810 ^@ http://purl.uniprot.org/uniprot/Q9HIM1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/273075:TA_RS00070 ^@ http://purl.uniprot.org/uniprot/Q9HM55 ^@ Function|||Similarity ^@ Belongs to the type-2 OGG1 family.|||Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). http://togogenome.org/gene/273075:TA_RS01675 ^@ http://purl.uniprot.org/uniprot/Q9HLA5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/273075:TA_RS04635 ^@ http://purl.uniprot.org/uniprot/Q05213 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/273075:TA_RS04865 ^@ http://purl.uniprot.org/uniprot/Q9HJM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/273075:TA_RS00885 ^@ http://purl.uniprot.org/uniprot/Q9HLQ2 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. Archaeal SPP-like hydrolase family.|||Binds 5 Mg(2+) ions per homodimer.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. Also has significant, but less efficient, pyrophosphatase activity, since it is able to catalyze the release of phosphate from inorganic pyrophosphate (PPi).|||Homodimer.|||Inhibited by Ca(2+) ions and by high chloride ion concentration. By contrast, low chloride concentration (up to 50 mM) slightly activate the enzyme. http://togogenome.org/gene/273075:TA_RS04595 ^@ http://purl.uniprot.org/uniprot/Q9HJS3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/273075:TA_RS01100 ^@ http://purl.uniprot.org/uniprot/Q9HLK9 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/273075:TA_RS04875 ^@ http://purl.uniprot.org/uniprot/Q9HJM3 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/273075:TA_RS04890 ^@ http://purl.uniprot.org/uniprot/Q9HJM0 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/273075:TA_RS05360 ^@ http://purl.uniprot.org/uniprot/Q9HJD4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/273075:TA_RS02945 ^@ http://purl.uniprot.org/uniprot/Q9HKM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS05200 ^@ http://purl.uniprot.org/uniprot/Q9HJG3 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/273075:TA_RS02695 ^@ http://purl.uniprot.org/uniprot/Q9HKS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/273075:TA_RS04000 ^@ http://purl.uniprot.org/uniprot/Q9HK29 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/273075:TA_RS04340 ^@ http://purl.uniprot.org/uniprot/Q9HJX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00120 ^@ http://purl.uniprot.org/uniprot/Q9HM47 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/273075:TA_RS03940 ^@ http://purl.uniprot.org/uniprot/Q9HK40 ^@ Similarity ^@ Belongs to the UPF0150 family. http://togogenome.org/gene/273075:TA_RS04100 ^@ http://purl.uniprot.org/uniprot/Q9HK14 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/273075:TA_RS03995 ^@ http://purl.uniprot.org/uniprot/Q9HK30 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/273075:TA_RS00505 ^@ http://purl.uniprot.org/uniprot/Q9HLX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS03355 ^@ http://purl.uniprot.org/uniprot/Q9HKF1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273075:TA_RS06340 ^@ http://purl.uniprot.org/uniprot/Q9HIV1 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/273075:TA_RS04730 ^@ http://purl.uniprot.org/uniprot/Q9HJQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/273075:TA_RS07490 ^@ http://purl.uniprot.org/uniprot/Q9HI95 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/273075:TA_RS01120 ^@ http://purl.uniprot.org/uniprot/Q9HLK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). http://togogenome.org/gene/273075:TA_RS05760 ^@ http://purl.uniprot.org/uniprot/Q9HJ59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/273075:TA_RS07590 ^@ http://purl.uniprot.org/uniprot/Q9HI80 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273075:TA_RS02925 ^@ http://purl.uniprot.org/uniprot/Q9HKN1 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/273075:TA_RS00105 ^@ http://purl.uniprot.org/uniprot/Q9HM49 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/273075:TA_RS02825 ^@ http://purl.uniprot.org/uniprot/Q9HKQ0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer. http://togogenome.org/gene/273075:TA_RS04075 ^@ http://purl.uniprot.org/uniprot/Q9HK16 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/273075:TA_RS04165 ^@ http://purl.uniprot.org/uniprot/Q9HK02 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/273075:TA_RS00855 ^@ http://purl.uniprot.org/uniprot/P21553 ^@ Activity Regulation|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically inhibited by NADH.|||Belongs to the citrate synthase family.|||Citrate synthase is found in nearly all cells capable of oxidative metabolism.|||Homodimer. http://togogenome.org/gene/273075:TA_RS04050 ^@ http://purl.uniprot.org/uniprot/Q9HK21 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/273075:TA_RS02905 ^@ http://purl.uniprot.org/uniprot/Q9HKN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/273075:TA_RS04935 ^@ http://purl.uniprot.org/uniprot/Q9HJL2 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/273075:TA_RS03000 ^@ http://purl.uniprot.org/uniprot/Q9HKL5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/273075:TA_RS04640 ^@ http://purl.uniprot.org/uniprot/Q9HJR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/273075:TA_RS04385 ^@ http://purl.uniprot.org/uniprot/Q9HJW4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS00090 ^@ http://purl.uniprot.org/uniprot/Q9HM52 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/273075:TA_RS07390 ^@ http://purl.uniprot.org/uniprot/Q9HIB3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/273075:TA_RS03840 ^@ http://purl.uniprot.org/uniprot/Q9HK58 ^@ Function|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Involved in the non-phosphorylated metabolic pathway of L-rhamnose catabolism. Catalyzes the oxidation of L-rhamnose to yield L-rhamnono-1,4-lactone. It can also oxidize L-lyxose and L-mannose, and uses only NADP. http://togogenome.org/gene/273075:TA_RS02045 ^@ http://purl.uniprot.org/uniprot/Q03587 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Binds 1 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is involved in DNA promoter recognition.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS02285 ^@ http://purl.uniprot.org/uniprot/Q9HL03 ^@ Similarity ^@ Belongs to the arsA ATPase family. http://togogenome.org/gene/273075:TA_RS00305 ^@ http://purl.uniprot.org/uniprot/Q9HM12 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/273075:TA_RS01605 ^@ http://purl.uniprot.org/uniprot/Q9HLB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS01080 ^@ http://purl.uniprot.org/uniprot/Q9HLL3 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/273075:TA_RS06510 ^@ http://purl.uniprot.org/uniprot/Q9HIR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS04540 ^@ http://purl.uniprot.org/uniprot/Q9HJT3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the carbohydrate kinase PfkB family.|||Can use Mg(2+) and Co(2+) with equal efficiency in vitro, and to a lesser extent, Mn(2+), but not Ni(2+).|||Homodimer.|||Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose-1-phosphate, or fructose-6-phosphate. http://togogenome.org/gene/273075:TA_RS06835 ^@ http://purl.uniprot.org/uniprot/Q9HIL6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/273075:TA_RS00890 ^@ http://purl.uniprot.org/uniprot/Q9HLQ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/273075:TA_RS05335 ^@ http://purl.uniprot.org/uniprot/Q9HJD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS06695 ^@ http://purl.uniprot.org/uniprot/Q9HIN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/273075:TA_RS05570 ^@ http://purl.uniprot.org/uniprot/Q9HJ94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). http://togogenome.org/gene/273075:TA_RS03410 ^@ http://purl.uniprot.org/uniprot/Q9HKE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS05860 ^@ http://purl.uniprot.org/uniprot/Q9HJ42 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS07030 ^@ http://purl.uniprot.org/uniprot/Q9HII0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer. http://togogenome.org/gene/273075:TA_RS02090 ^@ http://purl.uniprot.org/uniprot/P37981 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/273075:TA_RS01085 ^@ http://purl.uniprot.org/uniprot/Q9HLL2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnC family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/273075:TA_RS02820 ^@ http://purl.uniprot.org/uniprot/Q9HKQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS04450 ^@ http://purl.uniprot.org/uniprot/Q9HJV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS05710 ^@ http://purl.uniprot.org/uniprot/Q9HJ69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273075:TA_RS03975 ^@ http://purl.uniprot.org/uniprot/Q9HK34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS00230 ^@ http://purl.uniprot.org/uniprot/Q9HM27 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/273075:TA_RS05370 ^@ http://purl.uniprot.org/uniprot/Q9HJD2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/273075:TA_RS06185 ^@ http://purl.uniprot.org/uniprot/Q9HIY0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/273075:TA_RS05520 ^@ http://purl.uniprot.org/uniprot/Q9HJA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/273075:TA_RS05020 ^@ http://purl.uniprot.org/uniprot/Q9HJJ5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/273075:TA_RS04345 ^@ http://purl.uniprot.org/uniprot/O05209 ^@ Similarity|||Subunit ^@ Belongs to the AAA ATPase family. CDC48 subfamily.|||Homohexamer. Forms a ring-shaped particle. http://togogenome.org/gene/273075:TA_RS06005 ^@ http://purl.uniprot.org/uniprot/Q9HJ12 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/273075:TA_RS07325 ^@ http://purl.uniprot.org/uniprot/Q9HI35 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/273075:TA_RS03450 ^@ http://purl.uniprot.org/uniprot/Q9HKD2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/273075:TA_RS02630 ^@ http://purl.uniprot.org/uniprot/Q9HKT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS07415 ^@ http://purl.uniprot.org/uniprot/Q9HIB0 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/273075:TA_RS02815 ^@ http://purl.uniprot.org/uniprot/Q9HKQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GmhB family.|||Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273075:TA_RS06485 ^@ http://purl.uniprot.org/uniprot/Q9HIS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS06440 ^@ http://purl.uniprot.org/uniprot/Q9HIT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS02485 ^@ http://purl.uniprot.org/uniprot/Q9HKW6 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/273075:TA_RS02895 ^@ http://purl.uniprot.org/uniprot/Q9HKN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS01680 ^@ http://purl.uniprot.org/uniprot/Q9HLA4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/273075:TA_RS00325 ^@ http://purl.uniprot.org/uniprot/Q9HM08 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Binds two Mg(2+) per subunit.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/273075:TA_RS02265 ^@ http://purl.uniprot.org/uniprot/Q9HL07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/273075:TA_RS00025 ^@ http://purl.uniprot.org/uniprot/Q9P997 ^@ Function|||Miscellaneous|||PTM|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.|||The intein interrupts the ATP-binding site.|||This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation. http://togogenome.org/gene/273075:TA_RS06500 ^@ http://purl.uniprot.org/uniprot/P60746 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS04530 ^@ http://purl.uniprot.org/uniprot/Q9HJT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/273075:TA_RS04420 ^@ http://purl.uniprot.org/uniprot/Q9HJV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00475 ^@ http://purl.uniprot.org/uniprot/P02345 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.|||Homotetramer. http://togogenome.org/gene/273075:TA_RS00270 ^@ http://purl.uniprot.org/uniprot/Q9HM19 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/273075:TA_RS04685 ^@ http://purl.uniprot.org/uniprot/Q9HJQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/273075:TA_RS05235 ^@ http://purl.uniprot.org/uniprot/Q9HJF7 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/273075:TA_RS06480 ^@ http://purl.uniprot.org/uniprot/Q9HIS3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/273075:TA_RS04850 ^@ http://purl.uniprot.org/uniprot/Q9HJM7 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/273075:TA_RS05480 ^@ http://purl.uniprot.org/uniprot/Q9HJB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/273075:TA_RS06415 ^@ http://purl.uniprot.org/uniprot/Q9HIT6 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/273075:TA_RS00545 ^@ http://purl.uniprot.org/uniprot/Q9HLW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/273075:TA_RS05445 ^@ http://purl.uniprot.org/uniprot/Q9HJB8 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily. http://togogenome.org/gene/273075:TA_RS01835 ^@ http://purl.uniprot.org/uniprot/Q9HL75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Cytoplasm|||Homodimer or homotetramer. http://togogenome.org/gene/273075:TA_RS01865 ^@ http://purl.uniprot.org/uniprot/Q9HL70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/273075:TA_RS01445 ^@ http://purl.uniprot.org/uniprot/Q9HLE9 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/273075:TA_RS03525 ^@ http://purl.uniprot.org/uniprot/Q9HKB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS06270 ^@ http://purl.uniprot.org/uniprot/Q9HIW4 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/273075:TA_RS02160 ^@ http://purl.uniprot.org/uniprot/Q9HL27 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/273075:TA_RS05685 ^@ http://purl.uniprot.org/uniprot/Q9HJ74 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/273075:TA_RS07065 ^@ http://purl.uniprot.org/uniprot/Q9HIH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS05625 ^@ http://purl.uniprot.org/uniprot/P50023 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/273075:TA_RS05460 ^@ http://purl.uniprot.org/uniprot/Q9HJB5 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrB family. http://togogenome.org/gene/273075:TA_RS06785 ^@ http://purl.uniprot.org/uniprot/Q9HIM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/273075:TA_RS00525 ^@ http://purl.uniprot.org/uniprot/Q9HLX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with isopentenyl thiolophosphate (ISP). Has low activity with dimethylallyl phosphate (DMAP), 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro).|||Homodimer. http://togogenome.org/gene/273075:TA_RS04220 ^@ http://purl.uniprot.org/uniprot/Q9HJZ2 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/273075:TA_RS02420 ^@ http://purl.uniprot.org/uniprot/Q9HKX9 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/273075:TA_RS04445 ^@ http://purl.uniprot.org/uniprot/Q9HJV2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/273075:TA_RS00625 ^@ http://purl.uniprot.org/uniprot/Q9HLV0 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/273075:TA_RS00695 ^@ http://purl.uniprot.org/uniprot/Q9HLT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS06975 ^@ http://purl.uniprot.org/uniprot/Q9HII9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carbamate kinase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS07720 ^@ http://purl.uniprot.org/uniprot/P96086 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S41B family.|||Cytoplasm|||It is thought that substrate reaches the active site through the seven-bladed beta propeller channel, while products exit via the six-bladed beta propeller channel.|||Part of the Tricorn proteolytic complex. Assembles to form a hexameric toroid, 20 copies of which may then assemble to form an icosahedral supermolecule of 14.6 MDa.|||Tricorn degrades oligopeptides (probably derived from the proteasome) and channels the products to F1, F2 and F3 proteases, which then catalyze the terminal degradation step, yielding free amino acids. http://togogenome.org/gene/273075:TA_RS01665 ^@ http://purl.uniprot.org/uniprot/Q9HLA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/273075:TA_RS02690 ^@ http://purl.uniprot.org/uniprot/Q9HKS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS03230 ^@ http://purl.uniprot.org/uniprot/Q9HKH2 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/273075:TA_RS02065 ^@ http://purl.uniprot.org/uniprot/Q03590 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). http://togogenome.org/gene/273075:TA_RS06635 ^@ http://purl.uniprot.org/uniprot/P49403 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/273075:TA_RS03560 ^@ http://purl.uniprot.org/uniprot/Q9HKB0 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/273075:TA_RS05585 ^@ http://purl.uniprot.org/uniprot/Q9HJ91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/273075:TA_RS04610 ^@ http://purl.uniprot.org/uniprot/Q9HJS1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the mevalonate 3,5-bisphosphate decarboxylase family.|||Catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.|||Homodimer.|||It is proposed that Thermoplasmatales adapted the classical archaeal mevalonate pathway by replacing mevalonate 5-phosphate decarboxylase (MMD) with two specialized enzymes (mevalonate-3-phosphate 5-kinase and mevalonate 3,5-bisphosphate decarboxylase) in order to produce isoprenoids in extremely acidic environments. It was found that at low pH, the dual function enzyme MMD is unable to carry out the first phosphorylation step, yet retains its ability to perform decarboxylation. http://togogenome.org/gene/273075:TA_RS00215 ^@ http://purl.uniprot.org/uniprot/Q9HM28 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/273075:TA_RS01530 ^@ http://purl.uniprot.org/uniprot/Q9HLD2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/273075:TA_RS06335 ^@ http://purl.uniprot.org/uniprot/Q9HIV2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/273075:TA_RS02230 ^@ http://purl.uniprot.org/uniprot/Q9HL13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS06085 ^@ http://purl.uniprot.org/uniprot/Q9HIZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273075:TA_RS04350 ^@ http://purl.uniprot.org/uniprot/Q9HJX2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/273075:TA_RS05045 ^@ http://purl.uniprot.org/uniprot/P57704 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/273075:TA_RS06345 ^@ http://purl.uniprot.org/uniprot/Q9HIV0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.|||Homotetramer; dimer of dimers.|||Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273075:TA_RS02115 ^@ http://purl.uniprot.org/uniprot/Q9HL35 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.|||Cytoplasm|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits. http://togogenome.org/gene/273075:TA_RS01955 ^@ http://purl.uniprot.org/uniprot/Q9HL57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetyltransferase family.|||Involved in the protection against polyamine toxicity by regulating their concentration. Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. It can use a variety of substrates including spermidine, L-tryptophan, L-leucine, L-lysine, dopamine and tyramine.|||Monomer or homodimer. http://togogenome.org/gene/273075:TA_RS05375 ^@ http://purl.uniprot.org/uniprot/Q9HJD1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/273075:TA_RS01600 ^@ http://purl.uniprot.org/uniprot/Q9HLB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273075:TA_RS06770 ^@ http://purl.uniprot.org/uniprot/Q9HIM8 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/273075:TA_RS00610 ^@ http://purl.uniprot.org/uniprot/Q9HLV3 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family.|||Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Is specific for KDG.|||Homooctamer.|||Probably activated by phosphorylation and inhibited by dephosphorylation. http://togogenome.org/gene/273075:TA_RS00880 ^@ http://purl.uniprot.org/uniprot/Q9HLQ3 ^@ Caution|||Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273075:TA_RS00650 ^@ http://purl.uniprot.org/uniprot/Q9HLU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS03170 ^@ http://purl.uniprot.org/uniprot/Q9HKI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/273075:TA_RS06660 ^@ http://purl.uniprot.org/uniprot/Q9HIP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/273075:TA_RS05630 ^@ http://purl.uniprot.org/uniprot/Q9HJ83 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/273075:TA_RS00050 ^@ http://purl.uniprot.org/uniprot/Q9HM60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/273075:TA_RS00285 ^@ http://purl.uniprot.org/uniprot/Q9HM16 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/273075:TA_RS01595 ^@ http://purl.uniprot.org/uniprot/Q9HLC0 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/273075:TA_RS00670 ^@ http://purl.uniprot.org/uniprot/Q9HLU1 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/273075:TA_RS03850 ^@ http://purl.uniprot.org/uniprot/Q9HK56 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/273075:TA_RS00035 ^@ http://purl.uniprot.org/uniprot/Q9HM63 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/273075:TA_RS02675 ^@ http://purl.uniprot.org/uniprot/Q9HKS9 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Cell membrane|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. Can use both NADH and NADPH as electron donors. Also catalyzes the reduction of the naturally occurring 2,3-di-O-geranylgeranylglyceryl phosphate derivatives such as 2,3-di-O-phytyl-sn-glyceryl phosphate (DPHGP), 3-O-(2,3-di-O-phytyl-sn-glycero-phospho)-sn-glycerol (DPHGPG) and 2,3-di-O-phytyl-sn-glycero-phosphoethanolamine (DPHGPE). Is not active toward 2,3-di-O-geranylgeranylglycerol.|||Monomer.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/273075:TA_RS07045 ^@ http://purl.uniprot.org/uniprot/Q9HIH8 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/273075:TA_RS02610 ^@ http://purl.uniprot.org/uniprot/Q9HKU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS04800 ^@ http://purl.uniprot.org/uniprot/Q9HJN5 ^@ Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. http://togogenome.org/gene/273075:TA_RS00030 ^@ http://purl.uniprot.org/uniprot/Q9HM64 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/273075:TA_RS06150 ^@ http://purl.uniprot.org/uniprot/Q9HIY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/273075:TA_RS06455 ^@ http://purl.uniprot.org/uniprot/Q9HIS8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS06175 ^@ http://purl.uniprot.org/uniprot/Q9HIY2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||In the C-terminal section; belongs to the YjjX NTPase family.|||In the N-terminal section; belongs to the eukaryotic CoaD family.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/273075:TA_RS07335 ^@ http://purl.uniprot.org/uniprot/Q9HIC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS01040 ^@ http://purl.uniprot.org/uniprot/Q9HLM1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/273075:TA_RS00290 ^@ http://purl.uniprot.org/uniprot/Q9HM15 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/273075:TA_RS00585 ^@ http://purl.uniprot.org/uniprot/Q9HLV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. http://togogenome.org/gene/273075:TA_RS05935 ^@ http://purl.uniprot.org/uniprot/Q9HJ27 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS02440 ^@ http://purl.uniprot.org/uniprot/Q9HKX5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/273075:TA_RS04365 ^@ http://purl.uniprot.org/uniprot/Q9HJW8 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP). http://togogenome.org/gene/273075:TA_RS03930 ^@ http://purl.uniprot.org/uniprot/Q9HK41 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/273075:TA_RS01170 ^@ http://purl.uniprot.org/uniprot/Q9HLJ8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273075:TA_RS05255 ^@ http://purl.uniprot.org/uniprot/Q9HJF3 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/273075:TA_RS05995 ^@ http://purl.uniprot.org/uniprot/Q9HJ14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS06595 ^@ http://purl.uniprot.org/uniprot/Q9HIQ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/273075:TA_RS04555 ^@ http://purl.uniprot.org/uniprot/Q9HJT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/273075:TA_RS02600 ^@ http://purl.uniprot.org/uniprot/Q9HKU4 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/273075:TA_RS02450 ^@ http://purl.uniprot.org/uniprot/Q9HKX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS06590 ^@ http://purl.uniprot.org/uniprot/P48425 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms a Heterooligomeric complex of two stacked eight-membered rings.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.|||The N-terminus is blocked. http://togogenome.org/gene/273075:TA_RS05475 ^@ http://purl.uniprot.org/uniprot/Q9HJB2 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/273075:TA_RS05940 ^@ http://purl.uniprot.org/uniprot/Q9HJ26 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/273075:TA_RS07550 ^@ http://purl.uniprot.org/uniprot/P57673 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/273075:TA_RS06450 ^@ http://purl.uniprot.org/uniprot/Q9HIS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS03770 ^@ http://purl.uniprot.org/uniprot/Q9HK70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS03115 ^@ http://purl.uniprot.org/uniprot/Q9HKJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00190 ^@ http://purl.uniprot.org/uniprot/Q9HM32 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/273075:TA_RS04535 ^@ http://purl.uniprot.org/uniprot/Q9HJT4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/273075:TA_RS06925 ^@ http://purl.uniprot.org/uniprot/Q9HIJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/273075:TA_RS00265 ^@ http://purl.uniprot.org/uniprot/Q9HM21 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS00380 ^@ http://purl.uniprot.org/uniprot/O74110 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/273075:TA_RS05385 ^@ http://purl.uniprot.org/uniprot/Q9HJD0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS05185 ^@ http://purl.uniprot.org/uniprot/Q08717 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/273075:TA_RS07435 ^@ http://purl.uniprot.org/uniprot/Q9HIA6 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/273075:TA_RS04355 ^@ http://purl.uniprot.org/uniprot/Q9HJX1 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/273075:TA_RS05015 ^@ http://purl.uniprot.org/uniprot/Q9HJJ6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/273075:TA_RS04410 ^@ http://purl.uniprot.org/uniprot/Q9HJV9 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/273075:TA_RS06430 ^@ http://purl.uniprot.org/uniprot/Q9HIT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS06585 ^@ http://purl.uniprot.org/uniprot/Q9HIQ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/273075:TA_RS03010 ^@ http://purl.uniprot.org/uniprot/Q9HKL4 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the thermophilic archaeal actin family.|||Mg(2+) is required for polymerization. 4 mM MgCl(2) is sufficient to enhance the polymerization; however, higher concentrations of MgCl(2) suppresses polymerization. Polymerization is also suppressed by addition of NaCl, KCl or CaCl(2), with half suppression by about 100 mM, 10 mM and 18 mM, respectively.|||Polymerizes into bundles of filaments, forming a helix with a filament width of 5.5 nm and an axial repeating unit of 5.5 nm. Polymerization of Ta0583 requires NTP and is optimal with ATP, but GTP, UTP, CTP, and even the deoxy form of NTP can also support the polymerization reaction. Nucleoside diphosphate or AMP-PNP does not support polymerization. http://togogenome.org/gene/273075:TA_RS04885 ^@ http://purl.uniprot.org/uniprot/Q9HJM1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273075:TA_RS05640 ^@ http://purl.uniprot.org/uniprot/Q9HJ81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/273075:TA_RS00600 ^@ http://purl.uniprot.org/uniprot/Q9HLV6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/273075:TA_RS06530 ^@ http://purl.uniprot.org/uniprot/Q9HIR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS07650 ^@ http://purl.uniprot.org/uniprot/Q9HI67 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/273075:TA_RS05365 ^@ http://purl.uniprot.org/uniprot/Q9HJD3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). http://togogenome.org/gene/273075:TA_RS00395 ^@ http://purl.uniprot.org/uniprot/Q9HLZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. http://togogenome.org/gene/273075:TA_RS04880 ^@ http://purl.uniprot.org/uniprot/Q9HJM2 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/273075:TA_RS01460 ^@ http://purl.uniprot.org/uniprot/Q9HLE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273075:TA_RS06515 ^@ http://purl.uniprot.org/uniprot/P60835 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/273075:TA_RS02680 ^@ http://purl.uniprot.org/uniprot/P82853 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/273075:TA_RS07025 ^@ http://purl.uniprot.org/uniprot/Q9HII1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/273075:TA_RS02425 ^@ http://purl.uniprot.org/uniprot/Q9HKX8 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/273075:TA_RS00345 ^@ http://purl.uniprot.org/uniprot/Q9HM04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS06410 ^@ http://purl.uniprot.org/uniprot/P57670 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/273075:TA_RS07075 ^@ http://purl.uniprot.org/uniprot/Q9HIH2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/273075:TA_RS06155 ^@ http://purl.uniprot.org/uniprot/P57712 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/273075:TA_RS01210 ^@ http://purl.uniprot.org/uniprot/Q9HLJ3 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/273075:TA_RS02465 ^@ http://purl.uniprot.org/uniprot/Q9HKX0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/273075:TA_RS07585 ^@ http://purl.uniprot.org/uniprot/Q9HI81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS02705 ^@ http://purl.uniprot.org/uniprot/Q9HKS3 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/273075:TA_RS05620 ^@ http://purl.uniprot.org/uniprot/Q9HJ84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/273075:TA_RS04795 ^@ http://purl.uniprot.org/uniprot/Q9HJN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/273075:TA_RS04105 ^@ http://purl.uniprot.org/uniprot/Q9HK13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/273075:TA_RS01470 ^@ http://purl.uniprot.org/uniprot/Q9HLE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/273075:TA_RS06675 ^@ http://purl.uniprot.org/uniprot/Q9HIP0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS02040 ^@ http://purl.uniprot.org/uniprot/Q03588 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS04915 ^@ http://purl.uniprot.org/uniprot/Q9HJL6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/273075:TA_RS00315 ^@ http://purl.uniprot.org/uniprot/Q9HM10 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/273075:TA_RS04700 ^@ http://purl.uniprot.org/uniprot/Q9HJQ5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273075:TA_RS07495 ^@ http://purl.uniprot.org/uniprot/Q9HI94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/273075:TA_RS06490 ^@ http://purl.uniprot.org/uniprot/Q56231 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/273075:TA_RS05470 ^@ http://purl.uniprot.org/uniprot/Q9HJB3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/273075:TA_RS01455 ^@ http://purl.uniprot.org/uniprot/Q9HLE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS06710 ^@ http://purl.uniprot.org/uniprot/Q9HIN4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/273075:TA_RS01310 ^@ http://purl.uniprot.org/uniprot/Q9HLH3 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/273075:TA_RS05880 ^@ http://purl.uniprot.org/uniprot/Q9HJ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/273075:TA_RS07450 ^@ http://purl.uniprot.org/uniprot/Q9HIA3 ^@ Similarity ^@ Belongs to the BCKDHA family. http://togogenome.org/gene/273075:TA_RS05150 ^@ http://purl.uniprot.org/uniprot/P57706 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/273075:TA_RS01615 ^@ http://purl.uniprot.org/uniprot/Q9HLB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/273075:TA_RS04170 ^@ http://purl.uniprot.org/uniprot/Q9HK01 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family. Glyceraldehyde dehydrogenase subfamily.|||Homotetramer. Dimer of dimers.|||Inhibited by calcium, cadmium, copper and mercury ions. Stable for 2 hours at 60 degrees Celsius but activity is decreased to less than 50 percent within 20 minutes at 80 degrees Celsius. Two folds activity enhancement in the presence of 1 mM glutathione, DTT, or 2-mercaptoethanol. Complete activity inhibition by thiol-modifying reagents such as p-chloromercuribenzoic acid or p-hydroxy-mercuribenzoic acid.|||NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes. http://togogenome.org/gene/273075:TA_RS01280 ^@ http://purl.uniprot.org/uniprot/Q9HLH9 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/273075:TA_RS06740 ^@ http://purl.uniprot.org/uniprot/Q9HIN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GHMP kinase family.|||Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.|||Homodimer. http://togogenome.org/gene/273075:TA_RS00520 ^@ http://purl.uniprot.org/uniprot/Q9HLX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/273075:TA_RS05345 ^@ http://purl.uniprot.org/uniprot/Q9HJD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/273075:TA_RS00540 ^@ http://purl.uniprot.org/uniprot/Q9HLW8 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/273075:TA_RS06195 ^@ http://purl.uniprot.org/uniprot/Q9HIX8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/273075:TA_RS06215 ^@ http://purl.uniprot.org/uniprot/Q9HIX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/273075:TA_RS05670 ^@ http://purl.uniprot.org/uniprot/Q9HJ76 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/273075:TA_RS07535 ^@ http://purl.uniprot.org/uniprot/Q9HI87 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/273075:TA_RS06495 ^@ http://purl.uniprot.org/uniprot/Q56230 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/273075:TA_RS02275 ^@ http://purl.uniprot.org/uniprot/Q9HL05 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. http://togogenome.org/gene/273075:TA_RS02050 ^@ http://purl.uniprot.org/uniprot/Q03585 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS06685 ^@ http://purl.uniprot.org/uniprot/Q9HIN9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/273075:TA_RS05970 ^@ http://purl.uniprot.org/uniprot/Q9HJ19 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/273075:TA_RS00015 ^@ http://purl.uniprot.org/uniprot/Q9HM67 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/273075:TA_RS07575 ^@ http://purl.uniprot.org/uniprot/Q9HI83 ^@ Similarity ^@ Belongs to the peptidase S45 family. http://togogenome.org/gene/273075:TA_RS05270 ^@ http://purl.uniprot.org/uniprot/Q9HJF0 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/273075:TA_RS03615 ^@ http://purl.uniprot.org/uniprot/Q9HK98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00800 ^@ http://purl.uniprot.org/uniprot/Q9HLR7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/273075:TA_RS02455 ^@ http://purl.uniprot.org/uniprot/Q9HKX2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/273075:TA_RS03120 ^@ http://purl.uniprot.org/uniprot/Q9HKJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/273075:TA_RS06670 ^@ http://purl.uniprot.org/uniprot/Q9HIP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/273075:TA_RS05030 ^@ http://purl.uniprot.org/uniprot/Q9HJJ3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273075:TA_RS03385 ^@ http://purl.uniprot.org/uniprot/Q9HKE5 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/273075:TA_RS00375 ^@ http://purl.uniprot.org/uniprot/O59635 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/273075:TA_RS02780 ^@ http://purl.uniprot.org/uniprot/Q9HKR0 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/273075:TA_RS01245 ^@ http://purl.uniprot.org/uniprot/Q9HLI6 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS04490 ^@ http://purl.uniprot.org/uniprot/Q9HJU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS07420 ^@ http://purl.uniprot.org/uniprot/Q9HIA9 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/273075:TA_RS00710 ^@ http://purl.uniprot.org/uniprot/Q9HLT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS05605 ^@ http://purl.uniprot.org/uniprot/Q9HJ87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS03300 ^@ http://purl.uniprot.org/uniprot/P57693 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/273075:TA_RS05915 ^@ http://purl.uniprot.org/uniprot/Q9HJ31 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/273075:TA_RS05155 ^@ http://purl.uniprot.org/uniprot/Q9HJH0 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/273075:TA_RS07440 ^@ http://purl.uniprot.org/uniprot/Q9HIA5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/273075:TA_RS06765 ^@ http://purl.uniprot.org/uniprot/P57685 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KdpA family.|||Cell membrane|||Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.|||The system is composed of three essential subunits: KdpA, KdpB and KdpC. http://togogenome.org/gene/273075:TA_RS02445 ^@ http://purl.uniprot.org/uniprot/Q9HKX4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/273075:TA_RS00310 ^@ http://purl.uniprot.org/uniprot/Q9HM11 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/273075:TA_RS00920 ^@ http://purl.uniprot.org/uniprot/Q9HLP5 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/273075:TA_RS06855 ^@ http://purl.uniprot.org/uniprot/Q9HIL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273075:TA_RS05825 ^@ http://purl.uniprot.org/uniprot/Q9HJ48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/273075:TA_RS01515 ^@ http://purl.uniprot.org/uniprot/Q9HLD5 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/273075:TA_RS06205 ^@ http://purl.uniprot.org/uniprot/Q9HIX6 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/273075:TA_RS00905 ^@ http://purl.uniprot.org/uniprot/Q9HLP8 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/273075:TA_RS01205 ^@ http://purl.uniprot.org/uniprot/Q9HLJ4 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/273075:TA_RS02670 ^@ http://purl.uniprot.org/uniprot/Q9HKT0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/273075:TA_RS00125 ^@ http://purl.uniprot.org/uniprot/Q9HM46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS03200 ^@ http://purl.uniprot.org/uniprot/Q9HKH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. http://togogenome.org/gene/273075:TA_RS00320 ^@ http://purl.uniprot.org/uniprot/Q9HM09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS01850 ^@ http://purl.uniprot.org/uniprot/Q9HL72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/273075:TA_RS06470 ^@ http://purl.uniprot.org/uniprot/Q9HIS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS02960 ^@ http://purl.uniprot.org/uniprot/Q9HKM3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/273075:TA_RS04180 ^@ http://purl.uniprot.org/uniprot/Q9HJZ9 ^@ Similarity ^@ Belongs to the SHMT family. http://togogenome.org/gene/273075:TA_RS05170 ^@ http://purl.uniprot.org/uniprot/Q9HJG7 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/273075:TA_RS05565 ^@ http://purl.uniprot.org/uniprot/Q9HJ95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273075:TA_RS03040 ^@ http://purl.uniprot.org/uniprot/Q9HKK8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/273075:TA_RS05125 ^@ http://purl.uniprot.org/uniprot/Q9HJH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS04680 ^@ http://purl.uniprot.org/uniprot/Q9HJR0 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/273075:TA_RS01105 ^@ http://purl.uniprot.org/uniprot/Q9HLK8 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/273075:TA_RS02530 ^@ http://purl.uniprot.org/uniprot/Q9HKV7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/273075:TA_RS03275 ^@ http://purl.uniprot.org/uniprot/Q9HKG3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the CDC6/cdc18 family.|||Interacts with MCM.|||Involved in regulation of DNA replication. Stimulates the helicase activity of MCM via stimulation of its ATPase activity. Binding to MCM may result in conformational changes in MCM, leading to catalytic ATP hydrolysis by the helicase. Directly stimulates MCM movement along single-stranded and double-stranded DNA. Does not bind DNA.|||The N-terminal AAA+ ATPase domain and the C-terminal winged-helix (WH) domain are both required for stimulation of MCM activity. http://togogenome.org/gene/273075:TA_RS06015 ^@ http://purl.uniprot.org/uniprot/Q9HJ11 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/273075:TA_RS01560 ^@ http://purl.uniprot.org/uniprot/Q9HLC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/273075:TA_RS01840 ^@ http://purl.uniprot.org/uniprot/Q9HL74 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/273075:TA_RS06560 ^@ http://purl.uniprot.org/uniprot/Q9HIQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/273075:TA_RS04955 ^@ http://purl.uniprot.org/uniprot/Q9HJK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS02110 ^@ http://purl.uniprot.org/uniprot/Q9HL36 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/273075:TA_RS07125 ^@ http://purl.uniprot.org/uniprot/Q9HIG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS05755 ^@ http://purl.uniprot.org/uniprot/Q9HJ60 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). http://togogenome.org/gene/273075:TA_RS05895 ^@ http://purl.uniprot.org/uniprot/Q9HJ35 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/273075:TA_RS01465 ^@ http://purl.uniprot.org/uniprot/Q9HLE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS00700 ^@ http://purl.uniprot.org/uniprot/Q9HLT5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDX family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS05990 ^@ http://purl.uniprot.org/uniprot/Q9HJ15 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/273075:TA_RS05085 ^@ http://purl.uniprot.org/uniprot/Q9HJI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/273075:TA_RS05275 ^@ http://purl.uniprot.org/uniprot/Q9HJE9 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/273075:TA_RS00570 ^@ http://purl.uniprot.org/uniprot/Q9HLW2 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/273075:TA_RS01230 ^@ http://purl.uniprot.org/uniprot/Q9HLI9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS02965 ^@ http://purl.uniprot.org/uniprot/Q9HKM2 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/273075:TA_RS00420 ^@ http://purl.uniprot.org/uniprot/Q9HLZ2 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/273075:TA_RS03085 ^@ http://purl.uniprot.org/uniprot/Q9HKK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer. http://togogenome.org/gene/273075:TA_RS01150 ^@ http://purl.uniprot.org/uniprot/Q9HLK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00100 ^@ http://purl.uniprot.org/uniprot/Q9HM50 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/273075:TA_RS02255 ^@ http://purl.uniprot.org/uniprot/Q9HL09 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS05930 ^@ http://purl.uniprot.org/uniprot/Q9HJ28 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Although this protein is stated to be a nicotinate phosphoribosyltransferase, it has not been functionally characterized, and it might be a quinolinate phosphoribosyltransferase (QPRTase).|||Belongs to the NAPRTase family. Highly divergent.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Consists of three domains, an N-terminal domain, a central functional domain, and a unique C-terminal domain containing a zinc knuckle-like motif containing 4 cysteines.|||Homodimer. Forms a trimer of dimers in the crystal.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/273075:TA_RS01555 ^@ http://purl.uniprot.org/uniprot/O93654 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Part of the Tricorn proteolytic complex.|||Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids. http://togogenome.org/gene/273075:TA_RS04825 ^@ http://purl.uniprot.org/uniprot/Q9HJN0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273075:TA_RS04285 ^@ http://purl.uniprot.org/uniprot/Q9HJY2 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/273075:TA_RS06225 ^@ http://purl.uniprot.org/uniprot/Q9HIX1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS06220 ^@ http://purl.uniprot.org/uniprot/Q9HIX2 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/273075:TA_RS00615 ^@ http://purl.uniprot.org/uniprot/Q9HLV2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS07500 ^@ http://purl.uniprot.org/uniprot/P00218 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/273075:TA_RS04905 ^@ http://purl.uniprot.org/uniprot/Q9HJL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/273075:TA_RS04785 ^@ http://purl.uniprot.org/uniprot/Q9HJN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/273075:TA_RS07020 ^@ http://purl.uniprot.org/uniprot/Q9HII2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/273075:TA_RS06870 ^@ http://purl.uniprot.org/uniprot/Q9HIK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/273075:TA_RS01705 ^@ http://purl.uniprot.org/uniprot/Q9HL99 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273075:TA_RS01220 ^@ http://purl.uniprot.org/uniprot/Q9HLJ1 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/273075:TA_RS05540 ^@ http://purl.uniprot.org/uniprot/Q9HJA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/273075:TA_RS04430 ^@ http://purl.uniprot.org/uniprot/Q9HJV5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/273075:TA_RS06550 ^@ http://purl.uniprot.org/uniprot/Q9HIR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/273075:TA_RS06790 ^@ http://purl.uniprot.org/uniprot/Q9HIM4 ^@ Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family. http://togogenome.org/gene/273075:TA_RS00450 ^@ http://purl.uniprot.org/uniprot/Q9HLY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00770 ^@ http://purl.uniprot.org/uniprot/Q9HLS3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/273075:TA_RS02560 ^@ http://purl.uniprot.org/uniprot/Q9HKV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/273075:TA_RS05775 ^@ http://purl.uniprot.org/uniprot/Q9HJ56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/273075:TA_RS07735 ^@ http://purl.uniprot.org/uniprot/Q9HI54 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/273075:TA_RS04205 ^@ http://purl.uniprot.org/uniprot/Q9HJZ5 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/273075:TA_RS02055 ^@ http://purl.uniprot.org/uniprot/Q03586 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273075:TA_RS05985 ^@ http://purl.uniprot.org/uniprot/Q9HJ16 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS02320 ^@ http://purl.uniprot.org/uniprot/P19486 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/273075:TA_RS07635 ^@ http://purl.uniprot.org/uniprot/Q9HI70 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ 5'-deoxyadenosylcobalamine (coenzyme B12).|||Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Monomer.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/273075:TA_RS05575 ^@ http://purl.uniprot.org/uniprot/Q9HJ93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/273075:TA_RS06690 ^@ http://purl.uniprot.org/uniprot/Q9HIN8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/273075:TA_RS01005 ^@ http://purl.uniprot.org/uniprot/Q9HLM8 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). http://togogenome.org/gene/273075:TA_RS01315 ^@ http://purl.uniprot.org/uniprot/Q9HLH2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/273075:TA_RS02315 ^@ http://purl.uniprot.org/uniprot/Q9HKZ7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. http://togogenome.org/gene/273075:TA_RS03190 ^@ http://purl.uniprot.org/uniprot/Q9HKH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS04060 ^@ http://purl.uniprot.org/uniprot/Q9HK19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS01235 ^@ http://purl.uniprot.org/uniprot/Q9HLI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00795 ^@ http://purl.uniprot.org/uniprot/Q9HLR8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/273075:TA_RS06050 ^@ http://purl.uniprot.org/uniprot/Q9HI35 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/273075:TA_RS06460 ^@ http://purl.uniprot.org/uniprot/Q9HIS7 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/273075:TA_RS04525 ^@ http://purl.uniprot.org/uniprot/Q9HJT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS02330 ^@ http://purl.uniprot.org/uniprot/P26752 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).|||Cytoplasm http://togogenome.org/gene/273075:TA_RS02535 ^@ http://purl.uniprot.org/uniprot/Q9HKV6 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/273075:TA_RS07820 ^@ http://purl.uniprot.org/uniprot/Q9HI38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273075:TA_RS00385 ^@ http://purl.uniprot.org/uniprot/Q9HLZ9 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/273075:TA_RS01350 ^@ http://purl.uniprot.org/uniprot/Q9HLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/273075:TA_RS04550 ^@ http://purl.uniprot.org/uniprot/Q9HJT1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/273075:TA_RS00205 ^@ http://purl.uniprot.org/uniprot/Q9HM29 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/273075:TA_RS02085 ^@ http://purl.uniprot.org/uniprot/Q9HL40 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273075:TA_RS03500 ^@ http://purl.uniprot.org/uniprot/Q9HKC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS07910 ^@ http://purl.uniprot.org/uniprot/Q9HI74 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/273075:TA_RS03990 ^@ http://purl.uniprot.org/uniprot/Q9HK31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS05655 ^@ http://purl.uniprot.org/uniprot/Q9HJ78 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS00280 ^@ http://purl.uniprot.org/uniprot/Q9HM17 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/273075:TA_RS02655 ^@ http://purl.uniprot.org/uniprot/Q9HKT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273075:TA_RS01695 ^@ http://purl.uniprot.org/uniprot/Q9HLA1 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/273075:TA_RS03530 ^@ http://purl.uniprot.org/uniprot/Q9HKB6 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/273075:TA_RS02325 ^@ http://purl.uniprot.org/uniprot/P28079 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273075:TA_RS00245 ^@ http://purl.uniprot.org/uniprot/Q9HM24 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/273075:TA_RS05765 ^@ http://purl.uniprot.org/uniprot/Q9HJ58 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/273075:TA_RS06160 ^@ http://purl.uniprot.org/uniprot/Q9HIY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).|||Homodimer. http://togogenome.org/gene/273075:TA_RS00065 ^@ http://purl.uniprot.org/uniprot/Q9HM56 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/273075:TA_RS00480 ^@ http://purl.uniprot.org/uniprot/Q9HLY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS03505 ^@ http://purl.uniprot.org/uniprot/Q9HKC1 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).|||Belongs to the archease family. http://togogenome.org/gene/273075:TA_RS00275 ^@ http://purl.uniprot.org/uniprot/Q9HM18 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/273075:TA_RS05890 ^@ http://purl.uniprot.org/uniprot/Q9HJ36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). http://togogenome.org/gene/273075:TA_RS06505 ^@ http://purl.uniprot.org/uniprot/Q9HIR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/273075:TA_RS03915 ^@ http://purl.uniprot.org/uniprot/Q9HK44 ^@ Function|||Miscellaneous ^@ It is proposed that Thermoplasmatales adapted the classical archaeal mevalonate pathway by replacing mevalonate 5-phosphate decarboxylase (MMD) with two specialized enzymes (mevalonate-3-phosphate 5-kinase and mevalonate 3,5-bisphosphate decarboxylase) in order to produce isoprenoids in extremely acidic environments. It was found that at low pH, the dual function enzyme MMD is unable to carry out the first phosphorylation step, yet retains its ability to perform decarboxylation.|||Phosphorylates mevalonate 3-phosphate to form mevalonate 3,5-bisphosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate. http://togogenome.org/gene/273075:TA_RS01860 ^@ http://purl.uniprot.org/uniprot/Q9HL71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/273075:TA_RS02950 ^@ http://purl.uniprot.org/uniprot/Q9HKM5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/273075:TA_RS04320 ^@ http://purl.uniprot.org/uniprot/Q9HJX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/273075:TA_RS06030 ^@ http://purl.uniprot.org/uniprot/Q9HJ08 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/273075:TA_RS00460 ^@ http://purl.uniprot.org/uniprot/Q9HLY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS04245 ^@ http://purl.uniprot.org/uniprot/Q9HJY7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/273075:TA_RS00595 ^@ http://purl.uniprot.org/uniprot/P57718 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase (By similarity). http://togogenome.org/gene/273075:TA_RS00635 ^@ http://purl.uniprot.org/uniprot/Q9HLU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273075:TA_RS06540 ^@ http://purl.uniprot.org/uniprot/Q9HIR3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/273075:TA_RS05545 ^@ http://purl.uniprot.org/uniprot/Q9HJ99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS06650 ^@ http://purl.uniprot.org/uniprot/P25156 ^@ Activity Regulation|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The N-terminus is blocked.|||The configuration of the closed gate contains an opening large enough to allow rapid entry of tetrapeptides but able to impede the entry of proteins and longer peptides.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/273075:TA_RS06265 ^@ http://purl.uniprot.org/uniprot/Q9HIW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273075:TA_RS05595 ^@ http://purl.uniprot.org/uniprot/Q9HJ89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/273075:TA_RS00020 ^@ http://purl.uniprot.org/uniprot/Q9HM66 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/273075:TA_RS01475 ^@ http://purl.uniprot.org/uniprot/Q9HLE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm http://togogenome.org/gene/273075:TA_RS01050 ^@ http://purl.uniprot.org/uniprot/Q9HLL9 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/273075:TA_RS05770 ^@ http://purl.uniprot.org/uniprot/P57711 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/273075:TA_RS04405 ^@ http://purl.uniprot.org/uniprot/Q9HJW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS06545 ^@ http://purl.uniprot.org/uniprot/Q9HIR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/273075:TA_RS06955 ^@ http://purl.uniprot.org/uniprot/Q9HIJ2 ^@ Caution|||Function|||Induction|||Similarity|||Subunit ^@ Belongs to the phosphoglycerate mutase family.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Homodimer.|||Inhibited by vanadate. Inhibition can partially be relieved by EDTA.|||The original start site is 14 aa downstream of the start site shown here. Experiments from PubMed:17576516 were carried out with the original sequence. http://togogenome.org/gene/273075:TA_RS05800 ^@ http://purl.uniprot.org/uniprot/Q9HJ52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS00405 ^@ http://purl.uniprot.org/uniprot/Q9HLZ5 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/273075:TA_RS02850 ^@ http://purl.uniprot.org/uniprot/P57694 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/273075:TA_RS00210 ^@ http://purl.uniprot.org/uniprot/P57674 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a type II toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/273075:TA_RS04590 ^@ http://purl.uniprot.org/uniprot/Q9HJS4 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/273075:TA_RS04625 ^@ http://purl.uniprot.org/uniprot/P32044 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the pyruvate kinase family.|||Homotetramer.|||PubMed:1426985 has published some partial sequence, these sequences do not originate from T.acidophilum, rather they seem to be contaminated with human samples. http://togogenome.org/gene/273075:TA_RS02400 ^@ http://purl.uniprot.org/uniprot/Q9HKY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).|||In the C-terminal section; belongs to the endonuclease V family.|||In the N-terminal section; belongs to the MGMT family. http://togogenome.org/gene/273075:TA_RS04920 ^@ http://purl.uniprot.org/uniprot/Q9HJL5 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/273075:TA_RS06780 ^@ http://purl.uniprot.org/uniprot/Q9HIM6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/273075:TA_RS00715 ^@ http://purl.uniprot.org/uniprot/Q9HLT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273075:TA_RS04630 ^@ http://purl.uniprot.org/uniprot/P13203 ^@ Function|||Similarity|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with galactose as substrate, but not with mannose or glucose 6-phosphate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+). Physiologically, may be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.|||Homotetramer. http://togogenome.org/gene/273075:TA_RS07640 ^@ http://purl.uniprot.org/uniprot/Q9HI69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the formiminotransferase family.|||Catalyzes the transfer of the formyl group from N-formylglutamate to tetrahydrofolate (THF) to yield 5-formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5-formiminotetrahydrofolate (5-NH=CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrofolate (5,10-CH=THF).|||Cytoplasm http://togogenome.org/gene/273075:TA_RS05980 ^@ http://purl.uniprot.org/uniprot/Q9HJ17 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273075:TA_RS07760 ^@ http://purl.uniprot.org/uniprot/Q9HI47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.