http://togogenome.org/gene/2025808:CCZ37_RS09660 ^@ http://purl.uniprot.org/uniprot/A0A223MZD2 ^@ Function ^@ Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. http://togogenome.org/gene/2025808:CCZ37_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A223N113 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS03710 ^@ http://purl.uniprot.org/uniprot/A0A223MVY4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS02870 ^@ http://purl.uniprot.org/uniprot/A0A223MW75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase U32 family. UbiU subfamily.|||Forms an heterodimer with UbiV.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. http://togogenome.org/gene/2025808:CCZ37_RS11520 ^@ http://purl.uniprot.org/uniprot/A0A223N088 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/2025808:CCZ37_RS03120 ^@ http://purl.uniprot.org/uniprot/A0A223MVN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamD family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/2025808:CCZ37_RS09815 ^@ http://purl.uniprot.org/uniprot/A0A223MZ63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS11170 ^@ http://purl.uniprot.org/uniprot/A0A223MZW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptA family.|||Component of the lipopolysaccharide transport and assembly complex.|||Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.|||Periplasm http://togogenome.org/gene/2025808:CCZ37_RS15600 ^@ http://purl.uniprot.org/uniprot/A0A223N3Y0 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS10660 ^@ http://purl.uniprot.org/uniprot/A0A223MZN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family. ParE type 1 subfamily.|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/2025808:CCZ37_RS02020 ^@ http://purl.uniprot.org/uniprot/A0A223MVC0 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/2025808:CCZ37_RS18760 ^@ http://purl.uniprot.org/uniprot/A0A223N3W6 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/2025808:CCZ37_RS12935 ^@ http://purl.uniprot.org/uniprot/A0A223N162 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/2025808:CCZ37_RS09940 ^@ http://purl.uniprot.org/uniprot/A0A223MZI5 ^@ Similarity ^@ Belongs to the UPF0325 family. http://togogenome.org/gene/2025808:CCZ37_RS08045 ^@ http://purl.uniprot.org/uniprot/A0A223MYA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/2025808:CCZ37_RS04100 ^@ http://purl.uniprot.org/uniprot/A0A223MW41 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/2025808:CCZ37_RS02770 ^@ http://purl.uniprot.org/uniprot/A0A223MVJ4 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/2025808:CCZ37_RS13465 ^@ http://purl.uniprot.org/uniprot/A0A223N174 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS00215 ^@ http://purl.uniprot.org/uniprot/A0A223MV19 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/2025808:CCZ37_RS06760 ^@ http://purl.uniprot.org/uniprot/A0A223MXR4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS02830 ^@ http://purl.uniprot.org/uniprot/A0A223MVK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS03715 ^@ http://purl.uniprot.org/uniprot/A0A223MW28 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/2025808:CCZ37_RS09220 ^@ http://purl.uniprot.org/uniprot/A0A223MYW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/2025808:CCZ37_RS01255 ^@ http://purl.uniprot.org/uniprot/A0A223MUU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS12600 ^@ http://purl.uniprot.org/uniprot/A0A223N0Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/2025808:CCZ37_RS08805 ^@ http://purl.uniprot.org/uniprot/A0A223MYP2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS00750 ^@ http://purl.uniprot.org/uniprot/A0A223MUL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. http://togogenome.org/gene/2025808:CCZ37_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A223MW04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS00325 ^@ http://purl.uniprot.org/uniprot/A0A223MUB3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/2025808:CCZ37_RS01975 ^@ http://purl.uniprot.org/uniprot/A0A223MV30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LysR transcriptional regulatory family.|||Controls the transcription of genes involved in arginine and lysine metabolism.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS13660 ^@ http://purl.uniprot.org/uniprot/A0A223N1M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS03310 ^@ http://purl.uniprot.org/uniprot/A0A223MVW8 ^@ Function|||Similarity ^@ A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.|||Belongs to the NifU family. http://togogenome.org/gene/2025808:CCZ37_RS07150 ^@ http://purl.uniprot.org/uniprot/A0A223MYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09300 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliS family.|||cytosol http://togogenome.org/gene/2025808:CCZ37_RS09235 ^@ http://purl.uniprot.org/uniprot/A0A223MYX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliN/MopA/SpaO family.|||Cell membrane|||FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS00010 ^@ http://purl.uniprot.org/uniprot/A0A223MU80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/2025808:CCZ37_RS11075 ^@ http://purl.uniprot.org/uniprot/A0A223MZV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. RapA subfamily.|||Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.|||Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair. http://togogenome.org/gene/2025808:CCZ37_RS02515 ^@ http://purl.uniprot.org/uniprot/A0A223MVC4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/2025808:CCZ37_RS01715 ^@ http://purl.uniprot.org/uniprot/A0A223MV52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/2025808:CCZ37_RS15140 ^@ http://purl.uniprot.org/uniprot/A0A223N2A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS02270 ^@ http://purl.uniprot.org/uniprot/A0A223MV77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/2025808:CCZ37_RS02460 ^@ http://purl.uniprot.org/uniprot/A0A223MVD5 ^@ Function|||Subunit ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).|||Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/2025808:CCZ37_RS05165 ^@ http://purl.uniprot.org/uniprot/A0A223MWX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TER reductase family.|||Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS08085 ^@ http://purl.uniprot.org/uniprot/A0A223MYE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2025808:CCZ37_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A223MWI4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS04660 ^@ http://purl.uniprot.org/uniprot/A0A223MWF1 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily.|||Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. http://togogenome.org/gene/2025808:CCZ37_RS07650 ^@ http://purl.uniprot.org/uniprot/A0A223MY40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A223MVU5 ^@ Function|||Similarity ^@ Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.|||Belongs to the Nudix hydrolase family. RppH subfamily. http://togogenome.org/gene/2025808:CCZ37_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A223MUF6 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2025808:CCZ37_RS03345 ^@ http://purl.uniprot.org/uniprot/A0A223MW23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/2025808:CCZ37_RS03230 ^@ http://purl.uniprot.org/uniprot/A0A223MVP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/2025808:CCZ37_RS13330 ^@ http://purl.uniprot.org/uniprot/A0A223N0Z0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/2025808:CCZ37_RS01950 ^@ http://purl.uniprot.org/uniprot/A0A223MV18 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS14665 ^@ http://purl.uniprot.org/uniprot/A0A223N1N0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS05015 ^@ http://purl.uniprot.org/uniprot/A0A223MWN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbD/TolR family.|||Cell inner membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/2025808:CCZ37_RS03200 ^@ http://purl.uniprot.org/uniprot/A0A223MVW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane.|||Periplasm|||Secreted http://togogenome.org/gene/2025808:CCZ37_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A223MWI5 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/2025808:CCZ37_RS11415 ^@ http://purl.uniprot.org/uniprot/A0A223N067 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/2025808:CCZ37_RS10480 ^@ http://purl.uniprot.org/uniprot/A0A223N004 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/2025808:CCZ37_RS07820 ^@ http://purl.uniprot.org/uniprot/A0A223MY61 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS02950 ^@ http://purl.uniprot.org/uniprot/A0A223MVK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MutH family.|||Cytoplasm|||Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. http://togogenome.org/gene/2025808:CCZ37_RS14320 ^@ http://purl.uniprot.org/uniprot/A0A223N1K3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09980 ^@ http://purl.uniprot.org/uniprot/A0A223MZB0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/2025808:CCZ37_RS01110 ^@ http://purl.uniprot.org/uniprot/A0A223MUS3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS09455 ^@ http://purl.uniprot.org/uniprot/A0A223MZ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS02210 ^@ http://purl.uniprot.org/uniprot/A0A223MV64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoS subfamily.|||Cytoplasm|||Interacts with the RNA polymerase core enzyme.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. http://togogenome.org/gene/2025808:CCZ37_RS04635 ^@ http://purl.uniprot.org/uniprot/A0A223N0Y8 ^@ Function|||Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.|||DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. http://togogenome.org/gene/2025808:CCZ37_RS00465 ^@ http://purl.uniprot.org/uniprot/A0A223MUE3 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family. GreB subfamily.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. http://togogenome.org/gene/2025808:CCZ37_RS09905 ^@ http://purl.uniprot.org/uniprot/A0A223MZ84 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS02485 ^@ http://purl.uniprot.org/uniprot/A0A223MVH0 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/2025808:CCZ37_RS10795 ^@ http://purl.uniprot.org/uniprot/A0A223MZS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS00440 ^@ http://purl.uniprot.org/uniprot/A0A223MV48 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NfuA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.|||Homodimer.|||Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. http://togogenome.org/gene/2025808:CCZ37_RS08055 ^@ http://purl.uniprot.org/uniprot/A0A223MYA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS05510 ^@ http://purl.uniprot.org/uniprot/A0A223MX24 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS03350 ^@ http://purl.uniprot.org/uniprot/A0A223MVZ1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. http://togogenome.org/gene/2025808:CCZ37_RS10085 ^@ http://purl.uniprot.org/uniprot/A0A223MZD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/2025808:CCZ37_RS08820 ^@ http://purl.uniprot.org/uniprot/A0A223MZ77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YejK family.|||nucleoid http://togogenome.org/gene/2025808:CCZ37_RS08865 ^@ http://purl.uniprot.org/uniprot/A0A223MYS2 ^@ Similarity ^@ Belongs to the glutaredoxin family. Monothiol subfamily. http://togogenome.org/gene/2025808:CCZ37_RS07640 ^@ http://purl.uniprot.org/uniprot/A0A223MY21 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/2025808:CCZ37_RS12045 ^@ http://purl.uniprot.org/uniprot/A0A223N0G9 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/2025808:CCZ37_RS06485 ^@ http://purl.uniprot.org/uniprot/A0A223MXD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein PotD/PotF family.|||Periplasm|||Required for the activity of the bacterial periplasmic transport system of putrescine. http://togogenome.org/gene/2025808:CCZ37_RS11795 ^@ http://purl.uniprot.org/uniprot/A0A223N069 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/2025808:CCZ37_RS01615 ^@ http://purl.uniprot.org/uniprot/A0A223MVL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RraB family.|||Cytoplasm|||Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.|||Interacts with the C-terminal region of Rne. http://togogenome.org/gene/2025808:CCZ37_RS03090 ^@ http://purl.uniprot.org/uniprot/A0A223MVP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TrpR family.|||Cytoplasm|||Homodimer.|||This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription. http://togogenome.org/gene/2025808:CCZ37_RS14610 ^@ http://purl.uniprot.org/uniprot/A0A223N1L7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS00425 ^@ http://purl.uniprot.org/uniprot/A0A223MUK4 ^@ Similarity ^@ Belongs to the GSP N family. http://togogenome.org/gene/2025808:CCZ37_RS03275 ^@ http://purl.uniprot.org/uniprot/A0A223MVS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane|||Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).|||The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. http://togogenome.org/gene/2025808:CCZ37_RS13010 ^@ http://purl.uniprot.org/uniprot/A0A223N165 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/2025808:CCZ37_RS15120 ^@ http://purl.uniprot.org/uniprot/A0A223N2J4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/2025808:CCZ37_RS05010 ^@ http://purl.uniprot.org/uniprot/A0A223MWP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbB/TolQ family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/2025808:CCZ37_RS00795 ^@ http://purl.uniprot.org/uniprot/A0A223MUK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/2025808:CCZ37_RS08245 ^@ http://purl.uniprot.org/uniprot/A0A223MYM2 ^@ Similarity ^@ Belongs to the KAE1 / TsaD family. TsaB subfamily. http://togogenome.org/gene/2025808:CCZ37_RS08800 ^@ http://purl.uniprot.org/uniprot/A0A223MYR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09915 ^@ http://purl.uniprot.org/uniprot/A0A223MZA5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS05300 ^@ http://purl.uniprot.org/uniprot/A0A223MWR3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/2025808:CCZ37_RS03745 ^@ http://purl.uniprot.org/uniprot/A0A223MW62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0382 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS01065 ^@ http://purl.uniprot.org/uniprot/A0A223MUN2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Binds 1 zinc ion per subunit.|||Divalent metal cations. Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates. http://togogenome.org/gene/2025808:CCZ37_RS11945 ^@ http://purl.uniprot.org/uniprot/A0A223N0A3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MetJ family.|||Cytoplasm|||Does not bind DNA by a helix-turn-helix motif.|||Homodimer.|||This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. http://togogenome.org/gene/2025808:CCZ37_RS06365 ^@ http://purl.uniprot.org/uniprot/A0A223N157 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribosome modulation factor family.|||Cytoplasm|||During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes). http://togogenome.org/gene/2025808:CCZ37_RS11150 ^@ http://purl.uniprot.org/uniprot/A0A223N0A0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS04960 ^@ http://purl.uniprot.org/uniprot/A0A223MWM6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/2025808:CCZ37_RS14275 ^@ http://purl.uniprot.org/uniprot/A0A223N1F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS05680 ^@ http://purl.uniprot.org/uniprot/A0A223MX09 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/2025808:CCZ37_RS07725 ^@ http://purl.uniprot.org/uniprot/A0A223MY43 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS18090 ^@ http://purl.uniprot.org/uniprot/A0A223N3V5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS00355 ^@ http://purl.uniprot.org/uniprot/A0A223MUE5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS02815 ^@ http://purl.uniprot.org/uniprot/A0A223MVN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/2025808:CCZ37_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A223MWE3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS11445 ^@ http://purl.uniprot.org/uniprot/A0A223N075 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS06480 ^@ http://purl.uniprot.org/uniprot/A0A223MXG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS01570 ^@ http://purl.uniprot.org/uniprot/A0A223MUX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/2025808:CCZ37_RS15155 ^@ http://purl.uniprot.org/uniprot/A0A223N2A9 ^@ Similarity ^@ Belongs to the UPF0265 family. http://togogenome.org/gene/2025808:CCZ37_RS03125 ^@ http://purl.uniprot.org/uniprot/A0A223MVT9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/2025808:CCZ37_RS11120 ^@ http://purl.uniprot.org/uniprot/A0A223N028 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/2025808:CCZ37_RS10700 ^@ http://purl.uniprot.org/uniprot/A0A223MZP2 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/2025808:CCZ37_RS18715 ^@ http://purl.uniprot.org/uniprot/A0A223N3U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane http://togogenome.org/gene/2025808:CCZ37_RS09140 ^@ http://purl.uniprot.org/uniprot/A0A223MYW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS11500 ^@ http://purl.uniprot.org/uniprot/A0A223N0F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.|||Cytoplasm|||Specifically methylates the ribose of guanosine 2251 in 23S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS11565 ^@ http://purl.uniprot.org/uniprot/A0A223N0G1 ^@ Similarity ^@ Belongs to the UPF0270 family. http://togogenome.org/gene/2025808:CCZ37_RS12105 ^@ http://purl.uniprot.org/uniprot/A0A223N0B5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS04235 ^@ http://purl.uniprot.org/uniprot/A0A223N1F0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS08410 ^@ http://purl.uniprot.org/uniprot/A0A223MYR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS08215 ^@ http://purl.uniprot.org/uniprot/A0A223MYX4 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/2025808:CCZ37_RS05875 ^@ http://purl.uniprot.org/uniprot/A0A223MX23 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2025808:CCZ37_RS03570 ^@ http://purl.uniprot.org/uniprot/A0A223MW30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS08050 ^@ http://purl.uniprot.org/uniprot/A0A223MYV1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/2025808:CCZ37_RS09505 ^@ http://purl.uniprot.org/uniprot/A0A223MZ34 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/2025808:CCZ37_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A223MUD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP J family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS10495 ^@ http://purl.uniprot.org/uniprot/A0A223MZK5 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/2025808:CCZ37_RS06450 ^@ http://purl.uniprot.org/uniprot/A0A223MXM8 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TtcA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.|||Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.|||Cytoplasm|||Homodimer.|||The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster. http://togogenome.org/gene/2025808:CCZ37_RS07625 ^@ http://purl.uniprot.org/uniprot/A0A223MYP4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS01270 ^@ http://purl.uniprot.org/uniprot/A0A223MUX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PriB family.|||Binds single-stranded DNA at the primosome assembly site (PAS).|||Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome. http://togogenome.org/gene/2025808:CCZ37_RS08010 ^@ http://purl.uniprot.org/uniprot/A0A223MY99 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/2025808:CCZ37_RS11115 ^@ http://purl.uniprot.org/uniprot/A0A223MZV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS08885 ^@ http://purl.uniprot.org/uniprot/A0A223MYQ0 ^@ Similarity ^@ Belongs to the MlaA family. http://togogenome.org/gene/2025808:CCZ37_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A223MX55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LolA family.|||Monomer.|||Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).|||Periplasm http://togogenome.org/gene/2025808:CCZ37_RS01435 ^@ http://purl.uniprot.org/uniprot/A0A223MUS9 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/2025808:CCZ37_RS01790 ^@ http://purl.uniprot.org/uniprot/A0A223MUZ2 ^@ Function|||Similarity ^@ Belongs to the Fe(2+)-trafficking protein family.|||Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. http://togogenome.org/gene/2025808:CCZ37_RS00045 ^@ http://purl.uniprot.org/uniprot/A0A223MUD8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/2025808:CCZ37_RS04040 ^@ http://purl.uniprot.org/uniprot/A0A223MW68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LptE lipoprotein family.|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.|||Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. http://togogenome.org/gene/2025808:CCZ37_RS14560 ^@ http://purl.uniprot.org/uniprot/A0A223N246 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS01735 ^@ http://purl.uniprot.org/uniprot/A0A223MV01 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Homodimer.|||Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.|||The transmembrane domain is a dimerization domain. http://togogenome.org/gene/2025808:CCZ37_RS15745 ^@ http://purl.uniprot.org/uniprot/A0A223N2A4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A223MX07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS02630 ^@ http://purl.uniprot.org/uniprot/A0A223MVN6 ^@ Similarity ^@ Belongs to the UPF0231 family. http://togogenome.org/gene/2025808:CCZ37_RS03020 ^@ http://purl.uniprot.org/uniprot/A0A223MVL8 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2025808:CCZ37_RS06830 ^@ http://purl.uniprot.org/uniprot/A0A223MXM7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I fumarase family.|||Catalyzes the reversible hydration of fumarate to (S)-malate.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS10740 ^@ http://purl.uniprot.org/uniprot/A0A223N041 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/2025808:CCZ37_RS14910 ^@ http://purl.uniprot.org/uniprot/A0A223N266 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/2025808:CCZ37_RS07775 ^@ http://purl.uniprot.org/uniprot/A0A223MY58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS03065 ^@ http://purl.uniprot.org/uniprot/A0A223MVU7 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/2025808:CCZ37_RS00200 ^@ http://purl.uniprot.org/uniprot/A0A223MUG5 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/2025808:CCZ37_RS02365 ^@ http://purl.uniprot.org/uniprot/A0A223MV93 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. http://togogenome.org/gene/2025808:CCZ37_RS03245 ^@ http://purl.uniprot.org/uniprot/A0A223MVZ7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS04990 ^@ http://purl.uniprot.org/uniprot/A0A223MWL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS07155 ^@ http://purl.uniprot.org/uniprot/A0A223MXT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS02160 ^@ http://purl.uniprot.org/uniprot/A0A223MV54 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/2025808:CCZ37_RS18415 ^@ http://purl.uniprot.org/uniprot/A0A223N400 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Cell membrane|||Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11250 ^@ http://purl.uniprot.org/uniprot/A0A223N0B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/2025808:CCZ37_RS08185 ^@ http://purl.uniprot.org/uniprot/A0A223MYC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS10555 ^@ http://purl.uniprot.org/uniprot/A0A223MZL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsL family.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.|||Membrane|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/2025808:CCZ37_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A223MW64 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/2025808:CCZ37_RS07880 ^@ http://purl.uniprot.org/uniprot/A0A223MYT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/2025808:CCZ37_RS04065 ^@ http://purl.uniprot.org/uniprot/A0A223MWG0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS12230 ^@ http://purl.uniprot.org/uniprot/A0A223N0T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS01055 ^@ http://purl.uniprot.org/uniprot/A0A223MUM8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2025808:CCZ37_RS05040 ^@ http://purl.uniprot.org/uniprot/A0A223MWW2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS10465 ^@ http://purl.uniprot.org/uniprot/A0A223MZK8 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS04810 ^@ http://purl.uniprot.org/uniprot/A0A223MWM9 ^@ Similarity ^@ Belongs to the UPF0304 family. http://togogenome.org/gene/2025808:CCZ37_RS11355 ^@ http://purl.uniprot.org/uniprot/A0A223N066 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2025808:CCZ37_RS04025 ^@ http://purl.uniprot.org/uniprot/A0A223MW39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS08675 ^@ http://purl.uniprot.org/uniprot/A0A223MYM6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/2025808:CCZ37_RS13555 ^@ http://purl.uniprot.org/uniprot/A0A223N170 ^@ Similarity ^@ Belongs to the UPF0438 family. http://togogenome.org/gene/2025808:CCZ37_RS09085 ^@ http://purl.uniprot.org/uniprot/A0A223MYW0 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/2025808:CCZ37_RS17750 ^@ http://purl.uniprot.org/uniprot/A0A223N3D9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/2025808:CCZ37_RS11385 ^@ http://purl.uniprot.org/uniprot/A0A223N001 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/2025808:CCZ37_RS08030 ^@ http://purl.uniprot.org/uniprot/A0A223MYG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS02395 ^@ http://purl.uniprot.org/uniprot/A0A223MVB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZapD family.|||Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.|||Cytoplasm|||Interacts with FtsZ. http://togogenome.org/gene/2025808:CCZ37_RS10235 ^@ http://purl.uniprot.org/uniprot/A0A223MZG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS01965 ^@ http://purl.uniprot.org/uniprot/A0A223MVB1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscS (TC 1.A.23) family.|||Cell inner membrane|||Homoheptamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS08080 ^@ http://purl.uniprot.org/uniprot/A0A223MYI5 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2025808:CCZ37_RS00515 ^@ http://purl.uniprot.org/uniprot/A0A223MUH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/2025808:CCZ37_RS11825 ^@ http://purl.uniprot.org/uniprot/A0A223N0K4 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/2025808:CCZ37_RS13270 ^@ http://purl.uniprot.org/uniprot/A0A223N1B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11455 ^@ http://purl.uniprot.org/uniprot/A0A223N087 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS01465 ^@ http://purl.uniprot.org/uniprot/A0A223N1E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/2025808:CCZ37_RS10935 ^@ http://purl.uniprot.org/uniprot/A0A223MZU3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/2025808:CCZ37_RS05620 ^@ http://purl.uniprot.org/uniprot/A0A223MX42 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/2025808:CCZ37_RS15270 ^@ http://purl.uniprot.org/uniprot/A0A223N2C6 ^@ Similarity ^@ Belongs to the iron-containing alcohol dehydrogenase family. http://togogenome.org/gene/2025808:CCZ37_RS11910 ^@ http://purl.uniprot.org/uniprot/A0A223N089 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS13200 ^@ http://purl.uniprot.org/uniprot/A0A223N172 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HemG family.|||Binds 1 FMN non-covalently per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS09650 ^@ http://purl.uniprot.org/uniprot/A0A223MZ37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/2025808:CCZ37_RS02800 ^@ http://purl.uniprot.org/uniprot/A0A223MVI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11395 ^@ http://purl.uniprot.org/uniprot/A0A223N065 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS10670 ^@ http://purl.uniprot.org/uniprot/A0A223MZY0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase class-III family.|||Binds 2 Fe(2+) ions per subunit.|||Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. http://togogenome.org/gene/2025808:CCZ37_RS10000 ^@ http://purl.uniprot.org/uniprot/A0A223MZB2 ^@ Function|||Similarity ^@ Belongs to the FrsA family.|||Catalyzes the hydrolysis of esters. http://togogenome.org/gene/2025808:CCZ37_RS09900 ^@ http://purl.uniprot.org/uniprot/A0A223MZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS10625 ^@ http://purl.uniprot.org/uniprot/A0A223MZP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/2025808:CCZ37_RS09135 ^@ http://purl.uniprot.org/uniprot/A0A223MYW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS12150 ^@ http://purl.uniprot.org/uniprot/A0A223N0J2 ^@ Function|||Similarity|||Subunit ^@ Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.|||Belongs to the transcriptional regulatory Fis family.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS08340 ^@ http://purl.uniprot.org/uniprot/A0A223MYH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/2025808:CCZ37_RS04270 ^@ http://purl.uniprot.org/uniprot/A0A223MWJ0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase T family.|||Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.|||Homodimer.|||Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. http://togogenome.org/gene/2025808:CCZ37_RS08740 ^@ http://purl.uniprot.org/uniprot/A0A223MYY7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS17760 ^@ http://purl.uniprot.org/uniprot/A0A223N339 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/2025808:CCZ37_RS11450 ^@ http://purl.uniprot.org/uniprot/A0A223N0E2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/2025808:CCZ37_RS12615 ^@ http://purl.uniprot.org/uniprot/A0A223N0K9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/2025808:CCZ37_RS09930 ^@ http://purl.uniprot.org/uniprot/A0A223MZA3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/2025808:CCZ37_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A223MVH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DksA family.|||Cytoplasm|||Interacts directly with the RNA polymerase.|||Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. http://togogenome.org/gene/2025808:CCZ37_RS01015 ^@ http://purl.uniprot.org/uniprot/A0A223MUQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/2025808:CCZ37_RS18630 ^@ http://purl.uniprot.org/uniprot/A0A223N424 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Activated by ATP and maltotriose, which are both required for DNA binding.|||Belongs to the MalT family.|||Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.|||Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. http://togogenome.org/gene/2025808:CCZ37_RS09410 ^@ http://purl.uniprot.org/uniprot/A0A223MZ08 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/2025808:CCZ37_RS16945 ^@ http://purl.uniprot.org/uniprot/A0A223N2V9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS06225 ^@ http://purl.uniprot.org/uniprot/A0A223MXA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A223MXB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS15310 ^@ http://purl.uniprot.org/uniprot/A0A223N2C1 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/2025808:CCZ37_RS09405 ^@ http://purl.uniprot.org/uniprot/A0A223MZ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS15095 ^@ http://purl.uniprot.org/uniprot/A0A223N239 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/2025808:CCZ37_RS12440 ^@ http://purl.uniprot.org/uniprot/A0A223N0W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS18710 ^@ http://purl.uniprot.org/uniprot/A0A223N3V7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A223MWJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS08810 ^@ http://purl.uniprot.org/uniprot/A0A223MYP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS09320 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/2025808:CCZ37_RS01845 ^@ http://purl.uniprot.org/uniprot/A0A223MV24 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/2025808:CCZ37_RS16365 ^@ http://purl.uniprot.org/uniprot/A0A223N2I8 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/2025808:CCZ37_RS06105 ^@ http://purl.uniprot.org/uniprot/A0A223MXB8 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/2025808:CCZ37_RS11375 ^@ http://purl.uniprot.org/uniprot/A0A223N002 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/2025808:CCZ37_RS00450 ^@ http://purl.uniprot.org/uniprot/A0A223MUG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.|||Cytoplasm|||Monomer.|||The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. http://togogenome.org/gene/2025808:CCZ37_RS14375 ^@ http://purl.uniprot.org/uniprot/A0A223N1L5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/2025808:CCZ37_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A223MUP1 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/2025808:CCZ37_RS02640 ^@ http://purl.uniprot.org/uniprot/A0A223MVF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS08770 ^@ http://purl.uniprot.org/uniprot/A0A223MYP3 ^@ Function|||Similarity ^@ Belongs to the DUF177 domain family.|||Plays a role in synthesis, processing and/or stability of 23S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS12435 ^@ http://purl.uniprot.org/uniprot/A0A223N0H3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/2025808:CCZ37_RS01885 ^@ http://purl.uniprot.org/uniprot/A0A223N189 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/2025808:CCZ37_RS06790 ^@ http://purl.uniprot.org/uniprot/A0A223MXL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Amino-acid racemase able to utilize a broad range of substrates.|||Belongs to the alanine racemase family. Bsr subfamily.|||Periplasm http://togogenome.org/gene/2025808:CCZ37_RS09675 ^@ http://purl.uniprot.org/uniprot/A0A223MZ62 ^@ Function|||Similarity ^@ Belongs to the FlgM family.|||Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA. http://togogenome.org/gene/2025808:CCZ37_RS11940 ^@ http://purl.uniprot.org/uniprot/A0A223N0E7 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/2025808:CCZ37_RS03300 ^@ http://purl.uniprot.org/uniprot/A0A223MVY2 ^@ Cofactor|||Function ^@ Binds 1 [2Fe-2S] cluster.|||Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. http://togogenome.org/gene/2025808:CCZ37_RS00980 ^@ http://purl.uniprot.org/uniprot/A0A223MUM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS11475 ^@ http://purl.uniprot.org/uniprot/A0A223N015 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/2025808:CCZ37_RS05340 ^@ http://purl.uniprot.org/uniprot/A0A223MX29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A223MW01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/2025808:CCZ37_RS04255 ^@ http://purl.uniprot.org/uniprot/A0A223MW73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS14620 ^@ http://purl.uniprot.org/uniprot/A0A223N1U9 ^@ Cofactor|||Similarity ^@ Belongs to the PHP family.|||Binds 3 Zn(2+) ions per subunit. http://togogenome.org/gene/2025808:CCZ37_RS02700 ^@ http://purl.uniprot.org/uniprot/A0A223MW45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A223MW94 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/2025808:CCZ37_RS04510 ^@ http://purl.uniprot.org/uniprot/A0A223MWC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.|||Membrane|||Required for nicotinamide riboside transport across the inner membrane. http://togogenome.org/gene/2025808:CCZ37_RS12135 ^@ http://purl.uniprot.org/uniprot/A0A223N0R5 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/2025808:CCZ37_RS02730 ^@ http://purl.uniprot.org/uniprot/A0A223MVF9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HesB/IscA family.|||Binds 1 iron-sulfur cluster per subunit.|||Homodimer.|||Required for insertion of 4Fe-4S clusters for at least IspG. http://togogenome.org/gene/2025808:CCZ37_RS05310 ^@ http://purl.uniprot.org/uniprot/A0A223MXJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/2025808:CCZ37_RS06745 ^@ http://purl.uniprot.org/uniprot/A0A223MXL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. RhlE subfamily.|||Cytoplasm|||DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. http://togogenome.org/gene/2025808:CCZ37_RS16405 ^@ http://purl.uniprot.org/uniprot/A0A223N2N4 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/2025808:CCZ37_RS04295 ^@ http://purl.uniprot.org/uniprot/A0A223MWB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2025808:CCZ37_RS14470 ^@ http://purl.uniprot.org/uniprot/A0A223N1T4 ^@ Function ^@ Repressor involved in choline regulation of the bet genes.|||Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. http://togogenome.org/gene/2025808:CCZ37_RS14855 ^@ http://purl.uniprot.org/uniprot/A0A223N2C8 ^@ Function|||Similarity ^@ Belongs to the acetyltransferase family. EctA subfamily.|||Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. http://togogenome.org/gene/2025808:CCZ37_RS06580 ^@ http://purl.uniprot.org/uniprot/A0A223MXI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS07600 ^@ http://purl.uniprot.org/uniprot/A0A223MY38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L/F-transferase family.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. http://togogenome.org/gene/2025808:CCZ37_RS09490 ^@ http://purl.uniprot.org/uniprot/A0A223MZ26 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/2025808:CCZ37_RS13070 ^@ http://purl.uniprot.org/uniprot/A0A223N0S1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/2025808:CCZ37_RS03290 ^@ http://purl.uniprot.org/uniprot/A0A223MVR1 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/2025808:CCZ37_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A223MV92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS08190 ^@ http://purl.uniprot.org/uniprot/A0A223MYF3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS02780 ^@ http://purl.uniprot.org/uniprot/A0A223MVK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS14595 ^@ http://purl.uniprot.org/uniprot/A0A223N222 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/2025808:CCZ37_RS10065 ^@ http://purl.uniprot.org/uniprot/A0A223MZU2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrF family.|||Binds 1 [2Fe-2S] cluster.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. http://togogenome.org/gene/2025808:CCZ37_RS09240 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Cell inner membrane|||FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS15425 ^@ http://purl.uniprot.org/uniprot/A0A223N2C7 ^@ Function|||Similarity ^@ Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/2025808:CCZ37_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A223MXA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS08825 ^@ http://purl.uniprot.org/uniprot/A0A223MYP6 ^@ Similarity ^@ Belongs to the UPF0352 family. http://togogenome.org/gene/2025808:CCZ37_RS08755 ^@ http://purl.uniprot.org/uniprot/A0A223MYN6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/2025808:CCZ37_RS10835 ^@ http://purl.uniprot.org/uniprot/A0A223MZS4 ^@ Similarity ^@ Belongs to the SdhE FAD assembly factor family. http://togogenome.org/gene/2025808:CCZ37_RS09760 ^@ http://purl.uniprot.org/uniprot/A0A223MZ59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS09205 ^@ http://purl.uniprot.org/uniprot/A0A223MYV3 ^@ Similarity ^@ Belongs to the UPF0115 family. http://togogenome.org/gene/2025808:CCZ37_RS17515 ^@ http://purl.uniprot.org/uniprot/A0A223N334 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/2025808:CCZ37_RS09775 ^@ http://purl.uniprot.org/uniprot/A0A223MZF1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||Homotetramer.|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/2025808:CCZ37_RS12065 ^@ http://purl.uniprot.org/uniprot/A0A223N0B3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/2025808:CCZ37_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A223MX66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.|||Homotetramer; dimer of dimers.|||Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. http://togogenome.org/gene/2025808:CCZ37_RS15515 ^@ http://purl.uniprot.org/uniprot/A0A223N2P2 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS11735 ^@ http://purl.uniprot.org/uniprot/A0A223N059 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Cell inner membrane|||Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).|||In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09715 ^@ http://purl.uniprot.org/uniprot/A0A223MZE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS01685 ^@ http://purl.uniprot.org/uniprot/A0A223MUZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS11705 ^@ http://purl.uniprot.org/uniprot/A0A223N050 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS00645 ^@ http://purl.uniprot.org/uniprot/A0A223MUJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS10560 ^@ http://purl.uniprot.org/uniprot/A0A223MZV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS06305 ^@ http://purl.uniprot.org/uniprot/A0A223MXY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ProQ family.|||Cytoplasm|||RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. http://togogenome.org/gene/2025808:CCZ37_RS13550 ^@ http://purl.uniprot.org/uniprot/A0A223N1N5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS08795 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ8 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/2025808:CCZ37_RS11935 ^@ http://purl.uniprot.org/uniprot/A0A223N095 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS01200 ^@ http://purl.uniprot.org/uniprot/A0A223MUQ0 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/2025808:CCZ37_RS08205 ^@ http://purl.uniprot.org/uniprot/A0A223MYD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/2025808:CCZ37_RS05235 ^@ http://purl.uniprot.org/uniprot/A0A223MWT0 ^@ Function|||Similarity ^@ Belongs to the N(4)-acetylcytidine amidohydrolase family.|||Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). http://togogenome.org/gene/2025808:CCZ37_RS07710 ^@ http://purl.uniprot.org/uniprot/A0A223MYA5 ^@ Function|||Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/2025808:CCZ37_RS05770 ^@ http://purl.uniprot.org/uniprot/A0A223MX03 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/2025808:CCZ37_RS04585 ^@ http://purl.uniprot.org/uniprot/A0A223MWF7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homohexamer.|||In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the CobB/CobQ family.|||Involved in acetate metabolism.|||The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site. http://togogenome.org/gene/2025808:CCZ37_RS08475 ^@ http://purl.uniprot.org/uniprot/A0A223MYH5 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/2025808:CCZ37_RS08670 ^@ http://purl.uniprot.org/uniprot/A0A223MYL2 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/2025808:CCZ37_RS11465 ^@ http://purl.uniprot.org/uniprot/A0A223N078 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/2025808:CCZ37_RS11215 ^@ http://purl.uniprot.org/uniprot/A0A223N029 ^@ Similarity ^@ Belongs to the UPF0307 family. http://togogenome.org/gene/2025808:CCZ37_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A223MW29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS05395 ^@ http://purl.uniprot.org/uniprot/A0A223MX39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS08420 ^@ http://purl.uniprot.org/uniprot/A0A223MYI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Cob(I)alamin adenosyltransferase family.|||Cytoplasm|||Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. http://togogenome.org/gene/2025808:CCZ37_RS01190 ^@ http://purl.uniprot.org/uniprot/A0A223MUR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS01030 ^@ http://purl.uniprot.org/uniprot/A0A223MUM3 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2025808:CCZ37_RS02195 ^@ http://purl.uniprot.org/uniprot/A0A223MVV6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/2025808:CCZ37_RS10825 ^@ http://purl.uniprot.org/uniprot/A0A223N000 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS13265 ^@ http://purl.uniprot.org/uniprot/A0A223N0U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS05885 ^@ http://purl.uniprot.org/uniprot/A0A223MXT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/2025808:CCZ37_RS07895 ^@ http://purl.uniprot.org/uniprot/A0A223MY84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YciB family.|||Cell inner membrane|||Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. http://togogenome.org/gene/2025808:CCZ37_RS10430 ^@ http://purl.uniprot.org/uniprot/A0A223MZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11435 ^@ http://purl.uniprot.org/uniprot/A0A223N011 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS01280 ^@ http://purl.uniprot.org/uniprot/A0A223MUX8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS10125 ^@ http://purl.uniprot.org/uniprot/A0A223MZD8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2025808:CCZ37_RS13075 ^@ http://purl.uniprot.org/uniprot/A0A223N181 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS05975 ^@ http://purl.uniprot.org/uniprot/A0A223MXB6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS00535 ^@ http://purl.uniprot.org/uniprot/A0A223MUM4 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/2025808:CCZ37_RS13310 ^@ http://purl.uniprot.org/uniprot/A0A223N0X0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS06625 ^@ http://purl.uniprot.org/uniprot/A0A223MXJ0 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/2025808:CCZ37_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A223MUV6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS05025 ^@ http://purl.uniprot.org/uniprot/A0A223MWR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TolB family.|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||Periplasm|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/2025808:CCZ37_RS01250 ^@ http://purl.uniprot.org/uniprot/A0A223MUR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/2025808:CCZ37_RS13035 ^@ http://purl.uniprot.org/uniprot/A0A223N0U5 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). http://togogenome.org/gene/2025808:CCZ37_RS08260 ^@ http://purl.uniprot.org/uniprot/A0A223MYE2 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/2025808:CCZ37_RS09115 ^@ http://purl.uniprot.org/uniprot/A0A223MYU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SeqA family.|||Cytoplasm|||Homodimer. Polymerizes to form helical filaments.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. http://togogenome.org/gene/2025808:CCZ37_RS09960 ^@ http://purl.uniprot.org/uniprot/A0A223MZS3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. http://togogenome.org/gene/2025808:CCZ37_RS09955 ^@ http://purl.uniprot.org/uniprot/A0A223MZ98 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/2025808:CCZ37_RS02235 ^@ http://purl.uniprot.org/uniprot/A0A223MV80 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Membrane|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/2025808:CCZ37_RS18315 ^@ http://purl.uniprot.org/uniprot/A0A223N3Y5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.|||Belongs to the Lpp family.|||Cell outer membrane|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||cell wall http://togogenome.org/gene/2025808:CCZ37_RS02180 ^@ http://purl.uniprot.org/uniprot/A0A223MVC7 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/2025808:CCZ37_RS10610 ^@ http://purl.uniprot.org/uniprot/A0A223MZM7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/2025808:CCZ37_RS08500 ^@ http://purl.uniprot.org/uniprot/A0A223MYI7 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/2025808:CCZ37_RS01275 ^@ http://purl.uniprot.org/uniprot/A0A223MUR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/2025808:CCZ37_RS06000 ^@ http://purl.uniprot.org/uniprot/A0A223MX81 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/2025808:CCZ37_RS02145 ^@ http://purl.uniprot.org/uniprot/A0A223MVU8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/2025808:CCZ37_RS05080 ^@ http://purl.uniprot.org/uniprot/A0A223MWM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS06875 ^@ http://purl.uniprot.org/uniprot/A0A223MXL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS06645 ^@ http://purl.uniprot.org/uniprot/A0A223MXI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS07875 ^@ http://purl.uniprot.org/uniprot/A0A223MY70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/2025808:CCZ37_RS10790 ^@ http://purl.uniprot.org/uniprot/A0A223N051 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS11865 ^@ http://purl.uniprot.org/uniprot/A0A223N082 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/2025808:CCZ37_RS00760 ^@ http://purl.uniprot.org/uniprot/A0A223MUL9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoH subfamily.|||Cytoplasm|||Interacts with the RNA polymerase core enzyme.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. http://togogenome.org/gene/2025808:CCZ37_RS06900 ^@ http://purl.uniprot.org/uniprot/A0A223MXM9 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/2025808:CCZ37_RS00540 ^@ http://purl.uniprot.org/uniprot/A0A223MUF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure. http://togogenome.org/gene/2025808:CCZ37_RS09055 ^@ http://purl.uniprot.org/uniprot/A0A223MYS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/2025808:CCZ37_RS11770 ^@ http://purl.uniprot.org/uniprot/A0A223N0K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS08020 ^@ http://purl.uniprot.org/uniprot/A0A223MYA7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS01680 ^@ http://purl.uniprot.org/uniprot/A0A223MVM5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/2025808:CCZ37_RS07905 ^@ http://purl.uniprot.org/uniprot/A0A223MY98 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/2025808:CCZ37_RS01060 ^@ http://purl.uniprot.org/uniprot/A0A223MUR6 ^@ Similarity ^@ Belongs to the Rsd/AlgQ family. http://togogenome.org/gene/2025808:CCZ37_RS10885 ^@ http://purl.uniprot.org/uniprot/A0A223MZT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS11040 ^@ http://purl.uniprot.org/uniprot/A0A223MZV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptF/LptG family.|||Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).|||Membrane|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. http://togogenome.org/gene/2025808:CCZ37_RS11160 ^@ http://purl.uniprot.org/uniprot/A0A223MZV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the KdsC family.|||Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.|||Homotetramer. http://togogenome.org/gene/2025808:CCZ37_RS03360 ^@ http://purl.uniprot.org/uniprot/A0A223MVY0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/2025808:CCZ37_RS06370 ^@ http://purl.uniprot.org/uniprot/A0A223MXB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioester dehydratase family. FabA subfamily.|||Cytoplasm|||Homodimer.|||Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. http://togogenome.org/gene/2025808:CCZ37_RS00630 ^@ http://purl.uniprot.org/uniprot/A0A223MUM7 ^@ Function|||Similarity ^@ Belongs to the frataxin family.|||Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. http://togogenome.org/gene/2025808:CCZ37_RS09680 ^@ http://purl.uniprot.org/uniprot/A0A223MZM3 ^@ Function|||Similarity ^@ Belongs to the FlgN family.|||Required for the efficient initiation of filament assembly. http://togogenome.org/gene/2025808:CCZ37_RS09605 ^@ http://purl.uniprot.org/uniprot/A0A223MZ41 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Secreted http://togogenome.org/gene/2025808:CCZ37_RS13860 ^@ http://purl.uniprot.org/uniprot/A0A223N1P5 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04210 ^@ http://purl.uniprot.org/uniprot/A0A223MW70 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/2025808:CCZ37_RS03675 ^@ http://purl.uniprot.org/uniprot/A0A223N0X6 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/2025808:CCZ37_RS04755 ^@ http://purl.uniprot.org/uniprot/A0A223MWL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.|||Cell inner membrane|||Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.|||The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE). http://togogenome.org/gene/2025808:CCZ37_RS07610 ^@ http://purl.uniprot.org/uniprot/A0A223MY65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/2025808:CCZ37_RS06470 ^@ http://purl.uniprot.org/uniprot/A0A223MY09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/2025808:CCZ37_RS08335 ^@ http://purl.uniprot.org/uniprot/A0A223MYG2 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/2025808:CCZ37_RS12340 ^@ http://purl.uniprot.org/uniprot/A0A223N0V2 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/2025808:CCZ37_RS10880 ^@ http://purl.uniprot.org/uniprot/A0A223N007 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/2025808:CCZ37_RS12880 ^@ http://purl.uniprot.org/uniprot/A0A223N121 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS13210 ^@ http://purl.uniprot.org/uniprot/A0A223N0V4 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/2025808:CCZ37_RS11205 ^@ http://purl.uniprot.org/uniprot/A0A223N031 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS02445 ^@ http://purl.uniprot.org/uniprot/A0A223MVC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbC subfamily.|||Periplasm|||Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. http://togogenome.org/gene/2025808:CCZ37_RS15490 ^@ http://purl.uniprot.org/uniprot/A0A223N2T1 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2025808:CCZ37_RS00725 ^@ http://purl.uniprot.org/uniprot/A0A223MUI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS05420 ^@ http://purl.uniprot.org/uniprot/A0A223MWW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.|||Cell membrane|||Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF). http://togogenome.org/gene/2025808:CCZ37_RS00070 ^@ http://purl.uniprot.org/uniprot/A0A223MUA7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS03040 ^@ http://purl.uniprot.org/uniprot/A0A223MVN8 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/2025808:CCZ37_RS12160 ^@ http://purl.uniprot.org/uniprot/A0A223N0C2 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-I family. http://togogenome.org/gene/2025808:CCZ37_RS03190 ^@ http://purl.uniprot.org/uniprot/A0A223MVP0 ^@ Function ^@ This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. http://togogenome.org/gene/2025808:CCZ37_RS11460 ^@ http://purl.uniprot.org/uniprot/A0A223N012 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/2025808:CCZ37_RS11490 ^@ http://purl.uniprot.org/uniprot/A0A223N019 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||Methylated by PrmB.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/2025808:CCZ37_RS04980 ^@ http://purl.uniprot.org/uniprot/A0A223MWW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/2025808:CCZ37_RS10340 ^@ http://purl.uniprot.org/uniprot/A0A223MZH3 ^@ Function ^@ Acts as a radical domain for damaged PFL and possibly other radical proteins. http://togogenome.org/gene/2025808:CCZ37_RS08295 ^@ http://purl.uniprot.org/uniprot/A0A223MYP1 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/2025808:CCZ37_RS02440 ^@ http://purl.uniprot.org/uniprot/A0A223MVZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/2025808:CCZ37_RS14165 ^@ http://purl.uniprot.org/uniprot/A0A223N1D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS01800 ^@ http://purl.uniprot.org/uniprot/A0A223MUY6 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS08705 ^@ http://purl.uniprot.org/uniprot/A0A223MZ53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS11955 ^@ http://purl.uniprot.org/uniprot/A0A223N0G5 ^@ Similarity|||Subunit ^@ Homotetramer.|||In the C-terminal section; belongs to the homoserine dehydrogenase family.|||In the N-terminal section; belongs to the aspartokinase family. http://togogenome.org/gene/2025808:CCZ37_RS04680 ^@ http://purl.uniprot.org/uniprot/A0A223MWN0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||Multifunctional regulator of fatty acid metabolism. http://togogenome.org/gene/2025808:CCZ37_RS01675 ^@ http://purl.uniprot.org/uniprot/A0A223MV31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/2025808:CCZ37_RS08480 ^@ http://purl.uniprot.org/uniprot/A0A223MZ10 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/2025808:CCZ37_RS00210 ^@ http://purl.uniprot.org/uniprot/A0A223MUH2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Cytoplasm|||Homodimer.|||Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. http://togogenome.org/gene/2025808:CCZ37_RS13715 ^@ http://purl.uniprot.org/uniprot/A0A223N1L8 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/2025808:CCZ37_RS00385 ^@ http://purl.uniprot.org/uniprot/A0A223MV38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell inner membrane|||Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS03660 ^@ http://purl.uniprot.org/uniprot/A0A223MVX9 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/2025808:CCZ37_RS10800 ^@ http://purl.uniprot.org/uniprot/A0A223N124 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/2025808:CCZ37_RS00205 ^@ http://purl.uniprot.org/uniprot/A0A223MUA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family. TsaC subfamily.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. http://togogenome.org/gene/2025808:CCZ37_RS15000 ^@ http://purl.uniprot.org/uniprot/A0A223N1X7 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS09420 ^@ http://purl.uniprot.org/uniprot/A0A223MZ25 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/2025808:CCZ37_RS03315 ^@ http://purl.uniprot.org/uniprot/A0A223MWF5 ^@ Similarity ^@ Belongs to the HesB/IscA family. http://togogenome.org/gene/2025808:CCZ37_RS15005 ^@ http://purl.uniprot.org/uniprot/A0A223N1V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.|||Cell inner membrane|||Involved in transporting aromatic amino acids across the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09245 ^@ http://purl.uniprot.org/uniprot/A0A223MZF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FliL family.|||Cell inner membrane|||Controls the rotational direction of flagella during chemotaxis.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A223MW44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamE family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/2025808:CCZ37_RS13570 ^@ http://purl.uniprot.org/uniprot/A0A223N194 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).|||Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS11240 ^@ http://purl.uniprot.org/uniprot/A0A223MZY2 ^@ Function|||Similarity ^@ Belongs to the MurCDEF family. Mpl subfamily.|||Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate. http://togogenome.org/gene/2025808:CCZ37_RS08070 ^@ http://purl.uniprot.org/uniprot/A0A223MYB1 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2025808:CCZ37_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A223MUW7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2025808:CCZ37_RS09480 ^@ http://purl.uniprot.org/uniprot/A0A223MZB1 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/2025808:CCZ37_RS12445 ^@ http://purl.uniprot.org/uniprot/A0A223N0W5 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/2025808:CCZ37_RS18180 ^@ http://purl.uniprot.org/uniprot/A0A223N3K3 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/2025808:CCZ37_RS01660 ^@ http://purl.uniprot.org/uniprot/A0A223MV43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS14310 ^@ http://purl.uniprot.org/uniprot/A0A223N1Y2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS09325 ^@ http://purl.uniprot.org/uniprot/A0A223MZ86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/2025808:CCZ37_RS04180 ^@ http://purl.uniprot.org/uniprot/A0A223MWE8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS11775 ^@ http://purl.uniprot.org/uniprot/A0A223N0J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS06250 ^@ http://purl.uniprot.org/uniprot/A0A223MXC5 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/2025808:CCZ37_RS02975 ^@ http://purl.uniprot.org/uniprot/A0A223MVR0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS02140 ^@ http://purl.uniprot.org/uniprot/A0A223MVA8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/2025808:CCZ37_RS13255 ^@ http://purl.uniprot.org/uniprot/A0A223N1A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/2025808:CCZ37_RS08350 ^@ http://purl.uniprot.org/uniprot/A0A223MYQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS05505 ^@ http://purl.uniprot.org/uniprot/A0A223MWV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A223MXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS15135 ^@ http://purl.uniprot.org/uniprot/A0A223N2H6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS16785 ^@ http://purl.uniprot.org/uniprot/A0A223N2S3 ^@ Similarity ^@ Belongs to the RelE toxin family. http://togogenome.org/gene/2025808:CCZ37_RS02880 ^@ http://purl.uniprot.org/uniprot/A0A223MVL1 ^@ Function|||Similarity ^@ Belongs to the UbiT family.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor. http://togogenome.org/gene/2025808:CCZ37_RS03725 ^@ http://purl.uniprot.org/uniprot/A0A223MVY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS14565 ^@ http://purl.uniprot.org/uniprot/A0A223N1T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/2025808:CCZ37_RS10505 ^@ http://purl.uniprot.org/uniprot/A0A223MZK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/2025808:CCZ37_RS15460 ^@ http://purl.uniprot.org/uniprot/A0A223N2N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11430 ^@ http://purl.uniprot.org/uniprot/A0A223N081 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/2025808:CCZ37_RS01245 ^@ http://purl.uniprot.org/uniprot/A0A223MUT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/2025808:CCZ37_RS02230 ^@ http://purl.uniprot.org/uniprot/A0A223MVD6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/2025808:CCZ37_RS14380 ^@ http://purl.uniprot.org/uniprot/A0A223N1H9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/2025808:CCZ37_RS13250 ^@ http://purl.uniprot.org/uniprot/A0A223N182 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/2025808:CCZ37_RS08320 ^@ http://purl.uniprot.org/uniprot/A0A223MYF8 ^@ Similarity ^@ Belongs to the UPF0260 family. http://togogenome.org/gene/2025808:CCZ37_RS03255 ^@ http://purl.uniprot.org/uniprot/A0A223MVQ9 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/2025808:CCZ37_RS02250 ^@ http://purl.uniprot.org/uniprot/A0A223MV90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS02380 ^@ http://purl.uniprot.org/uniprot/A0A223MVA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/2025808:CCZ37_RS15245 ^@ http://purl.uniprot.org/uniprot/A0A223N2B5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS00060 ^@ http://purl.uniprot.org/uniprot/A0A223MUY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfur carrier protein TusA family.|||Cytoplasm|||Sulfur carrier protein which probably makes part of a sulfur-relay system. http://togogenome.org/gene/2025808:CCZ37_RS05030 ^@ http://purl.uniprot.org/uniprot/A0A223MWM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Pal lipoprotein family.|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/2025808:CCZ37_RS08780 ^@ http://purl.uniprot.org/uniprot/A0A223N130 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/2025808:CCZ37_RS03665 ^@ http://purl.uniprot.org/uniprot/A0A223MW96 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS01830 ^@ http://purl.uniprot.org/uniprot/A0A223MV12 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/2025808:CCZ37_RS03990 ^@ http://purl.uniprot.org/uniprot/A0A223MW58 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS09050 ^@ http://purl.uniprot.org/uniprot/A0A223N116 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04785 ^@ http://purl.uniprot.org/uniprot/A0A223MWQ2 ^@ Similarity ^@ Belongs to the UPF0434 family. http://togogenome.org/gene/2025808:CCZ37_RS14350 ^@ http://purl.uniprot.org/uniprot/A0A223N1Y5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS12130 ^@ http://purl.uniprot.org/uniprot/A0A223N0R1 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/2025808:CCZ37_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A223MUZ3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/2025808:CCZ37_RS04855 ^@ http://purl.uniprot.org/uniprot/A0A223MWK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS02410 ^@ http://purl.uniprot.org/uniprot/A0A223MVC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS13150 ^@ http://purl.uniprot.org/uniprot/A0A223N1G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04560 ^@ http://purl.uniprot.org/uniprot/A0A223MWM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A223MW87 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/2025808:CCZ37_RS08760 ^@ http://purl.uniprot.org/uniprot/A0A223MZ61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/2025808:CCZ37_RS07770 ^@ http://purl.uniprot.org/uniprot/A0A223MY53 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/2025808:CCZ37_RS17570 ^@ http://purl.uniprot.org/uniprot/A0A223N3J1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/2025808:CCZ37_RS03005 ^@ http://purl.uniprot.org/uniprot/A0A223MVL2 ^@ Function|||Similarity ^@ Belongs to the ribF family.|||Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. http://togogenome.org/gene/2025808:CCZ37_RS13235 ^@ http://purl.uniprot.org/uniprot/A0A223N1B3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/2025808:CCZ37_RS10680 ^@ http://purl.uniprot.org/uniprot/A0A223MZP4 ^@ Function|||Similarity ^@ Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.|||Belongs to the Nudix hydrolase family. NudF subfamily. http://togogenome.org/gene/2025808:CCZ37_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A223MVD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2025808:CCZ37_RS05810 ^@ http://purl.uniprot.org/uniprot/A0A223MXD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS12620 ^@ http://purl.uniprot.org/uniprot/A0A223N0K0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/2025808:CCZ37_RS04675 ^@ http://purl.uniprot.org/uniprot/A0A223MWF6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/2025808:CCZ37_RS08450 ^@ http://purl.uniprot.org/uniprot/A0A223MYJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS11570 ^@ http://purl.uniprot.org/uniprot/A0A223N0F8 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/2025808:CCZ37_RS15615 ^@ http://purl.uniprot.org/uniprot/A0A223N2V5 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/2025808:CCZ37_RS11970 ^@ http://purl.uniprot.org/uniprot/A0A223N0N0 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/2025808:CCZ37_RS10230 ^@ http://purl.uniprot.org/uniprot/A0A223MZF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11915 ^@ http://purl.uniprot.org/uniprot/A0A223N091 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/2025808:CCZ37_RS11180 ^@ http://purl.uniprot.org/uniprot/A0A223N037 ^@ Function|||Similarity ^@ Belongs to the sigma-54 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/2025808:CCZ37_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A223MV91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcdB/MmdB/OadB family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane|||Heterotrimer of an alpha, a beta and a gamma subunit.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04315 ^@ http://purl.uniprot.org/uniprot/A0A223MWE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2025808:CCZ37_RS09425 ^@ http://purl.uniprot.org/uniprot/A0A223MZA2 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/2025808:CCZ37_RS09010 ^@ http://purl.uniprot.org/uniprot/A0A223MYT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS03730 ^@ http://purl.uniprot.org/uniprot/A0A223MWA6 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/2025808:CCZ37_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A223N1D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DEAD box helicase family. RhlB subfamily.|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. http://togogenome.org/gene/2025808:CCZ37_RS15555 ^@ http://purl.uniprot.org/uniprot/A0A223N2K5 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2025808:CCZ37_RS02600 ^@ http://purl.uniprot.org/uniprot/A0A223N1D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09260 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS11370 ^@ http://purl.uniprot.org/uniprot/A0A223N003 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2025808:CCZ37_RS01470 ^@ http://purl.uniprot.org/uniprot/A0A223MUV5 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/2025808:CCZ37_RS18765 ^@ http://purl.uniprot.org/uniprot/A0A223N3V4 ^@ Function ^@ Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. http://togogenome.org/gene/2025808:CCZ37_RS02435 ^@ http://purl.uniprot.org/uniprot/A0A223MVG6 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/2025808:CCZ37_RS12625 ^@ http://purl.uniprot.org/uniprot/A0A223N0U0 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/2025808:CCZ37_RS06335 ^@ http://purl.uniprot.org/uniprot/A0A223MXK9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS01070 ^@ http://purl.uniprot.org/uniprot/A0A223MUW6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS06010 ^@ http://purl.uniprot.org/uniprot/A0A223MX88 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. UbiG/COQ3 family.|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/2025808:CCZ37_RS07865 ^@ http://purl.uniprot.org/uniprot/A0A223MYA6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS06340 ^@ http://purl.uniprot.org/uniprot/A0A223MXG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZapC family.|||Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.|||Cytoplasm|||Interacts directly with FtsZ. http://togogenome.org/gene/2025808:CCZ37_RS13340 ^@ http://purl.uniprot.org/uniprot/A0A223N179 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11400 ^@ http://purl.uniprot.org/uniprot/A0A223N0D5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A223N146 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS08605 ^@ http://purl.uniprot.org/uniprot/A0A223MZ23 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS11195 ^@ http://purl.uniprot.org/uniprot/A0A223MZX2 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/2025808:CCZ37_RS04070 ^@ http://purl.uniprot.org/uniprot/A0A223MWD0 ^@ Similarity ^@ Belongs to the PhoH family. http://togogenome.org/gene/2025808:CCZ37_RS01580 ^@ http://purl.uniprot.org/uniprot/A0A223MUW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Cell inner membrane|||Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS00165 ^@ http://purl.uniprot.org/uniprot/A0A223MV06 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/2025808:CCZ37_RS00400 ^@ http://purl.uniprot.org/uniprot/A0A223MUF5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GSP I family.|||Cell inner membrane|||Cleaved by prepilin peptidase.|||Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.|||Membrane|||Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus. http://togogenome.org/gene/2025808:CCZ37_RS12760 ^@ http://purl.uniprot.org/uniprot/A0A223N115 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/2025808:CCZ37_RS10035 ^@ http://purl.uniprot.org/uniprot/A0A223MZB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS00360 ^@ http://purl.uniprot.org/uniprot/A0A223MUC5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/2025808:CCZ37_RS02705 ^@ http://purl.uniprot.org/uniprot/A0A223MVG9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/2025808:CCZ37_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A223MVR7 ^@ Similarity ^@ Belongs to the adrenodoxin/putidaredoxin family. http://togogenome.org/gene/2025808:CCZ37_RS09810 ^@ http://purl.uniprot.org/uniprot/A0A223MZ72 ^@ Similarity ^@ Belongs to the transglycosylase Slt family. http://togogenome.org/gene/2025808:CCZ37_RS05270 ^@ http://purl.uniprot.org/uniprot/A0A223MX18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS04260 ^@ http://purl.uniprot.org/uniprot/A0A223MWD2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS09450 ^@ http://purl.uniprot.org/uniprot/A0A223MZ24 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/2025808:CCZ37_RS02375 ^@ http://purl.uniprot.org/uniprot/A0A223MVF8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/2025808:CCZ37_RS01945 ^@ http://purl.uniprot.org/uniprot/A0A223MV45 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.|||Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS13300 ^@ http://purl.uniprot.org/uniprot/A0A223N192 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/2025808:CCZ37_RS10895 ^@ http://purl.uniprot.org/uniprot/A0A223MZT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/2025808:CCZ37_RS02835 ^@ http://purl.uniprot.org/uniprot/A0A223MVH4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/2025808:CCZ37_RS07655 ^@ http://purl.uniprot.org/uniprot/A0A223MY42 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/2025808:CCZ37_RS01115 ^@ http://purl.uniprot.org/uniprot/A0A223MUP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-to-5' exoribonuclease specific for small oligoribonucleotides.|||Belongs to the oligoribonuclease family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS17660 ^@ http://purl.uniprot.org/uniprot/A0A223N317 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the NapC/NirT/NrfH family.|||Binds 4 heme groups per subunit. http://togogenome.org/gene/2025808:CCZ37_RS10350 ^@ http://purl.uniprot.org/uniprot/A0A223N1I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A223MXC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dsrC/tusE family.|||Cytoplasm|||Part of a sulfur-relay system. http://togogenome.org/gene/2025808:CCZ37_RS01195 ^@ http://purl.uniprot.org/uniprot/A0A223MUS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS10755 ^@ http://purl.uniprot.org/uniprot/A0A223MZQ8 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/2025808:CCZ37_RS00080 ^@ http://purl.uniprot.org/uniprot/A0A223MUA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the serine/threonine dehydratase family.|||Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.|||Homotetramer. http://togogenome.org/gene/2025808:CCZ37_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A223MUB6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. http://togogenome.org/gene/2025808:CCZ37_RS08985 ^@ http://purl.uniprot.org/uniprot/A0A223MYS4 ^@ Function|||Similarity ^@ Belongs to the GTP-binding SRP family.|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/2025808:CCZ37_RS07185 ^@ http://purl.uniprot.org/uniprot/A0A223MXZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS18680 ^@ http://purl.uniprot.org/uniprot/A0A223N427 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Catalyzes the sodium-dependent uptake of extracellular L-proline.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS12200 ^@ http://purl.uniprot.org/uniprot/A0A223N0J8 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2025808:CCZ37_RS13225 ^@ http://purl.uniprot.org/uniprot/A0A223N0V0 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS11965 ^@ http://purl.uniprot.org/uniprot/A0A223N0A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZapB family.|||Cytoplasm|||Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.|||Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. http://togogenome.org/gene/2025808:CCZ37_RS06505 ^@ http://purl.uniprot.org/uniprot/A0A223MXI6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MobA family.|||Cytoplasm|||Monomer.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/2025808:CCZ37_RS12050 ^@ http://purl.uniprot.org/uniprot/A0A223N0B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS10585 ^@ http://purl.uniprot.org/uniprot/A0A223MZM4 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/2025808:CCZ37_RS00340 ^@ http://purl.uniprot.org/uniprot/A0A223MUC9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A223MVI4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/2025808:CCZ37_RS10570 ^@ http://purl.uniprot.org/uniprot/A0A223MZM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS12875 ^@ http://purl.uniprot.org/uniprot/A0A223N100 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09090 ^@ http://purl.uniprot.org/uniprot/A0A223MYV7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/2025808:CCZ37_RS12635 ^@ http://purl.uniprot.org/uniprot/A0A223N0M1 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS04520 ^@ http://purl.uniprot.org/uniprot/A0A223MX40 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/2025808:CCZ37_RS09495 ^@ http://purl.uniprot.org/uniprot/A0A223MZ46 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/2025808:CCZ37_RS11675 ^@ http://purl.uniprot.org/uniprot/A0A223N044 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS09795 ^@ http://purl.uniprot.org/uniprot/A0A223MZ76 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS04095 ^@ http://purl.uniprot.org/uniprot/A0A223MW74 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS03580 ^@ http://purl.uniprot.org/uniprot/A0A223MVZ2 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/2025808:CCZ37_RS11360 ^@ http://purl.uniprot.org/uniprot/A0A223MZZ3 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/2025808:CCZ37_RS11480 ^@ http://purl.uniprot.org/uniprot/A0A223N092 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/2025808:CCZ37_RS03185 ^@ http://purl.uniprot.org/uniprot/A0A223MVS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RdgC family.|||May be involved in recombination.|||nucleoid http://togogenome.org/gene/2025808:CCZ37_RS14170 ^@ http://purl.uniprot.org/uniprot/A0A223N1W8 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/2025808:CCZ37_RS10310 ^@ http://purl.uniprot.org/uniprot/A0A223MZG9 ^@ Similarity ^@ Belongs to the UPF0246 family. http://togogenome.org/gene/2025808:CCZ37_RS02030 ^@ http://purl.uniprot.org/uniprot/A0A223MV41 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/2025808:CCZ37_RS07525 ^@ http://purl.uniprot.org/uniprot/A0A223MYM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MukF family.|||Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.|||Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.|||nucleoid http://togogenome.org/gene/2025808:CCZ37_RS03400 ^@ http://purl.uniprot.org/uniprot/A0A223MW12 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS01025 ^@ http://purl.uniprot.org/uniprot/A0A223MUT6 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/2025808:CCZ37_RS05565 ^@ http://purl.uniprot.org/uniprot/A0A223MWW6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS08765 ^@ http://purl.uniprot.org/uniprot/A0A223MYN5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2025808:CCZ37_RS08090 ^@ http://purl.uniprot.org/uniprot/A0A223MYA8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/2025808:CCZ37_RS09630 ^@ http://purl.uniprot.org/uniprot/A0A223MZL3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/2025808:CCZ37_RS00985 ^@ http://purl.uniprot.org/uniprot/A0A223MUQ4 ^@ Function|||Similarity ^@ Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.|||Belongs to the biotin--protein ligase family. http://togogenome.org/gene/2025808:CCZ37_RS13410 ^@ http://purl.uniprot.org/uniprot/A0A223N1K9 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/2025808:CCZ37_RS14090 ^@ http://purl.uniprot.org/uniprot/A0A223N1T0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS03650 ^@ http://purl.uniprot.org/uniprot/A0A223MVX6 ^@ Similarity ^@ Belongs to the UPF0253 family. http://togogenome.org/gene/2025808:CCZ37_RS01995 ^@ http://purl.uniprot.org/uniprot/A0A223MV42 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/2025808:CCZ37_RS02350 ^@ http://purl.uniprot.org/uniprot/A0A223MVB6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/2025808:CCZ37_RS09210 ^@ http://purl.uniprot.org/uniprot/A0A223MYY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type III secretion exporter family.|||Cell membrane|||Membrane|||Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/2025808:CCZ37_RS01090 ^@ http://purl.uniprot.org/uniprot/A0A223MVE7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS11210 ^@ http://purl.uniprot.org/uniprot/A0A223MZW7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/2025808:CCZ37_RS11440 ^@ http://purl.uniprot.org/uniprot/A0A223N013 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/2025808:CCZ37_RS09230 ^@ http://purl.uniprot.org/uniprot/A0A223MYY5 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliO/MopB family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS03240 ^@ http://purl.uniprot.org/uniprot/A0A223MVQ2 ^@ Similarity ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. http://togogenome.org/gene/2025808:CCZ37_RS11420 ^@ http://purl.uniprot.org/uniprot/A0A223N008 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/2025808:CCZ37_RS04310 ^@ http://purl.uniprot.org/uniprot/A0A223MW82 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2025808:CCZ37_RS10500 ^@ http://purl.uniprot.org/uniprot/A0A223MZL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/2025808:CCZ37_RS06585 ^@ http://purl.uniprot.org/uniprot/A0A223MXH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS11065 ^@ http://purl.uniprot.org/uniprot/A0A223N021 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/2025808:CCZ37_RS11340 ^@ http://purl.uniprot.org/uniprot/A0A223MZZ9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2025808:CCZ37_RS05595 ^@ http://purl.uniprot.org/uniprot/A0A223MX14 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TorC/TorY family.|||Binds 5 heme groups per subunit.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS03380 ^@ http://purl.uniprot.org/uniprot/A0A223MVS4 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/2025808:CCZ37_RS17575 ^@ http://purl.uniprot.org/uniprot/A0A223N3R6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/2025808:CCZ37_RS11365 ^@ http://purl.uniprot.org/uniprot/A0A223N056 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/2025808:CCZ37_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A223MV70 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/2025808:CCZ37_RS02385 ^@ http://purl.uniprot.org/uniprot/A0A223MVF6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/2025808:CCZ37_RS08975 ^@ http://purl.uniprot.org/uniprot/A0A223MYU3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sigma-70 factor family. FliA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. http://togogenome.org/gene/2025808:CCZ37_RS03080 ^@ http://purl.uniprot.org/uniprot/A0A223MWB3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/2025808:CCZ37_RS11405 ^@ http://purl.uniprot.org/uniprot/A0A223N076 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2025808:CCZ37_RS04075 ^@ http://purl.uniprot.org/uniprot/A0A223MW53 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A223MVP9 ^@ Similarity ^@ Belongs to the GppA/Ppx family. http://togogenome.org/gene/2025808:CCZ37_RS02750 ^@ http://purl.uniprot.org/uniprot/A0A223MVM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS09080 ^@ http://purl.uniprot.org/uniprot/A0A223MYW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS09075 ^@ http://purl.uniprot.org/uniprot/A0A223MZ45 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/2025808:CCZ37_RS11380 ^@ http://purl.uniprot.org/uniprot/A0A223N073 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/2025808:CCZ37_RS05950 ^@ http://purl.uniprot.org/uniprot/A0A223MX75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/2025808:CCZ37_RS12580 ^@ http://purl.uniprot.org/uniprot/A0A223N0K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS05085 ^@ http://purl.uniprot.org/uniprot/A0A223MWS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS04265 ^@ http://purl.uniprot.org/uniprot/A0A223MW81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS06415 ^@ http://purl.uniprot.org/uniprot/A0A223MXE9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CcoP / FixP family.|||Binds 2 heme C groups per subunit.|||C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.|||Cell inner membrane|||Component of the cbb3-type cytochrome c oxidase. http://togogenome.org/gene/2025808:CCZ37_RS04290 ^@ http://purl.uniprot.org/uniprot/A0A223MX02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2025808:CCZ37_RS08290 ^@ http://purl.uniprot.org/uniprot/A0A223MYG9 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/2025808:CCZ37_RS04175 ^@ http://purl.uniprot.org/uniprot/A0A223MW67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/2025808:CCZ37_RS03550 ^@ http://purl.uniprot.org/uniprot/A0A223MVW2 ^@ Similarity ^@ Belongs to the ribosome association toxin RatA family. http://togogenome.org/gene/2025808:CCZ37_RS11485 ^@ http://purl.uniprot.org/uniprot/A0A223N018 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS11595 ^@ http://purl.uniprot.org/uniprot/A0A223N0B1 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/2025808:CCZ37_RS03280 ^@ http://purl.uniprot.org/uniprot/A0A223MVQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/2025808:CCZ37_RS05785 ^@ http://purl.uniprot.org/uniprot/A0A223MX32 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/2025808:CCZ37_RS03215 ^@ http://purl.uniprot.org/uniprot/A0A223MWD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS08040 ^@ http://purl.uniprot.org/uniprot/A0A223MYA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LapA family.|||Cell inner membrane|||Involved in the assembly of lipopolysaccharide (LPS).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS00990 ^@ http://purl.uniprot.org/uniprot/A0A223MUM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic pantothenate kinase family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS10870 ^@ http://purl.uniprot.org/uniprot/A0A223MZS6 ^@ Function|||Similarity|||Subunit ^@ Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.|||Belongs to the ZapA family. Type 1 subfamily.|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/2025808:CCZ37_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A223MW99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS08725 ^@ http://purl.uniprot.org/uniprot/A0A223MYN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglycosylase MltG family.|||Cell inner membrane|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/2025808:CCZ37_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A223MX92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS18310 ^@ http://purl.uniprot.org/uniprot/A0A223N425 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2025808:CCZ37_RS10025 ^@ http://purl.uniprot.org/uniprot/A0A223MZB3 ^@ Cofactor|||Similarity ^@ Belongs to the RimK family.|||Binds 2 magnesium or manganese ions per subunit. http://togogenome.org/gene/2025808:CCZ37_RS02840 ^@ http://purl.uniprot.org/uniprot/A0A223MVL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS07100 ^@ http://purl.uniprot.org/uniprot/A0A223MYE6 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/2025808:CCZ37_RS13275 ^@ http://purl.uniprot.org/uniprot/A0A223N0V7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS05330 ^@ http://purl.uniprot.org/uniprot/A0A223MWW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/2025808:CCZ37_RS18455 ^@ http://purl.uniprot.org/uniprot/A0A223N3P9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS15200 ^@ http://purl.uniprot.org/uniprot/A0A223N259 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/2025808:CCZ37_RS10635 ^@ http://purl.uniprot.org/uniprot/A0A223MZN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AFG1 ATPase family. ZapE subfamily.|||Cytoplasm|||Interacts with FtsZ.|||Reduces the stability of FtsZ polymers in the presence of ATP. http://togogenome.org/gene/2025808:CCZ37_RS00020 ^@ http://purl.uniprot.org/uniprot/A0A223MU61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/2025808:CCZ37_RS11495 ^@ http://purl.uniprot.org/uniprot/A0A223N086 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2025808:CCZ37_RS11390 ^@ http://purl.uniprot.org/uniprot/A0A223N006 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/2025808:CCZ37_RS11085 ^@ http://purl.uniprot.org/uniprot/A0A223MZV2 ^@ Similarity ^@ Belongs to the PhoH family. http://togogenome.org/gene/2025808:CCZ37_RS15225 ^@ http://purl.uniprot.org/uniprot/A0A223N2K8 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/2025808:CCZ37_RS11140 ^@ http://purl.uniprot.org/uniprot/A0A223MZW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MlaE permease family.|||Cell inner membrane|||Membrane|||Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD). http://togogenome.org/gene/2025808:CCZ37_RS11410 ^@ http://purl.uniprot.org/uniprot/A0A223N005 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/2025808:CCZ37_RS11835 ^@ http://purl.uniprot.org/uniprot/A0A223N074 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.|||Belongs to the FrdD family.|||Cell membrane|||Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD). http://togogenome.org/gene/2025808:CCZ37_RS00100 ^@ http://purl.uniprot.org/uniprot/A0A223MU86 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/2025808:CCZ37_RS09255 ^@ http://purl.uniprot.org/uniprot/A0A223MYW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliJ family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS17870 ^@ http://purl.uniprot.org/uniprot/A0A223N330 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS04000 ^@ http://purl.uniprot.org/uniprot/A0A223MW26 ^@ Similarity ^@ Belongs to the UPF0250 family. http://togogenome.org/gene/2025808:CCZ37_RS04105 ^@ http://purl.uniprot.org/uniprot/A0A223MWA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CysZ family.|||Cell inner membrane|||High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway. http://togogenome.org/gene/2025808:CCZ37_RS01825 ^@ http://purl.uniprot.org/uniprot/A0A223MVP5 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/2025808:CCZ37_RS01260 ^@ http://purl.uniprot.org/uniprot/A0A223MUQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/2025808:CCZ37_RS06280 ^@ http://purl.uniprot.org/uniprot/A0A223MXA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS10435 ^@ http://purl.uniprot.org/uniprot/A0A223MZJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS12640 ^@ http://purl.uniprot.org/uniprot/A0A223N0Z8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoid occlusion factor SlmA family.|||Homodimer. Interacts with FtsZ.|||Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.|||nucleoid http://togogenome.org/gene/2025808:CCZ37_RS04220 ^@ http://purl.uniprot.org/uniprot/A0A223MWG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS01210 ^@ http://purl.uniprot.org/uniprot/A0A223MUQ1 ^@ Similarity ^@ Belongs to the SlyX family. http://togogenome.org/gene/2025808:CCZ37_RS02895 ^@ http://purl.uniprot.org/uniprot/A0A223MVJ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein S18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS11980 ^@ http://purl.uniprot.org/uniprot/A0A223N0N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2025808:CCZ37_RS18785 ^@ http://purl.uniprot.org/uniprot/A0A223N1K9 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/2025808:CCZ37_RS09880 ^@ http://purl.uniprot.org/uniprot/A0A223MZ93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the skp family.|||Homotrimer.|||Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.|||Periplasm http://togogenome.org/gene/2025808:CCZ37_RS11860 ^@ http://purl.uniprot.org/uniprot/A0A223N080 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/2025808:CCZ37_RS08430 ^@ http://purl.uniprot.org/uniprot/A0A223MZ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS17585 ^@ http://purl.uniprot.org/uniprot/A0A223N3A5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS09780 ^@ http://purl.uniprot.org/uniprot/A0A223MZ80 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2025808:CCZ37_RS13700 ^@ http://purl.uniprot.org/uniprot/A0A223N3W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A223MV34 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/2025808:CCZ37_RS08485 ^@ http://purl.uniprot.org/uniprot/A0A223MYI0 ^@ Function|||Similarity ^@ Belongs to the MoaB/Mog family.|||May be involved in the biosynthesis of molybdopterin. http://togogenome.org/gene/2025808:CCZ37_RS10600 ^@ http://purl.uniprot.org/uniprot/A0A223MZM6 ^@ Similarity ^@ Belongs to the GST superfamily. HSP26 family. http://togogenome.org/gene/2025808:CCZ37_RS04720 ^@ http://purl.uniprot.org/uniprot/A0A223MWQ5 ^@ Similarity ^@ Belongs to the UPF0227 family. http://togogenome.org/gene/2025808:CCZ37_RS01630 ^@ http://purl.uniprot.org/uniprot/A0A223MUX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS12785 ^@ http://purl.uniprot.org/uniprot/A0A223N0P1 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/2025808:CCZ37_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A223MV66 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/2025808:CCZ37_RS11470 ^@ http://purl.uniprot.org/uniprot/A0A223N016 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/2025808:CCZ37_RS13895 ^@ http://purl.uniprot.org/uniprot/A0A223N1F5 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/2025808:CCZ37_RS09860 ^@ http://purl.uniprot.org/uniprot/A0A223MZ99 ^@ Function|||Similarity ^@ Belongs to the LpxB family.|||Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/2025808:CCZ37_RS13985 ^@ http://purl.uniprot.org/uniprot/A0A223N1E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.|||Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.|||Cell membrane http://togogenome.org/gene/2025808:CCZ37_RS08370 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS13020 ^@ http://purl.uniprot.org/uniprot/A0A223N0Q9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/2025808:CCZ37_RS09625 ^@ http://purl.uniprot.org/uniprot/A0A223MZ55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.|||Bacterial flagellum basal body|||Belongs to the FlgH family.|||Cell outer membrane|||Membrane|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. http://togogenome.org/gene/2025808:CCZ37_RS11175 ^@ http://purl.uniprot.org/uniprot/A0A223MZW6 ^@ Function|||Similarity ^@ Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/2025808:CCZ37_RS08635 ^@ http://purl.uniprot.org/uniprot/A0A223MYX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 5DNU family.|||Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS07685 ^@ http://purl.uniprot.org/uniprot/A0A223MY27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone-like protein H-NS family.|||nucleoid http://togogenome.org/gene/2025808:CCZ37_RS15690 ^@ http://purl.uniprot.org/uniprot/A0A223N2S1 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/2025808:CCZ37_RS01020 ^@ http://purl.uniprot.org/uniprot/A0A223N0X3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2025808:CCZ37_RS05470 ^@ http://purl.uniprot.org/uniprot/A0A223MWW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. http://togogenome.org/gene/2025808:CCZ37_RS15285 ^@ http://purl.uniprot.org/uniprot/A0A223N1Z4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/2025808:CCZ37_RS01035 ^@ http://purl.uniprot.org/uniprot/A0A223MUT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/2025808:CCZ37_RS03110 ^@ http://purl.uniprot.org/uniprot/A0A223MVX8 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.|||Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS08125 ^@ http://purl.uniprot.org/uniprot/A0A223MYB9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2025808:CCZ37_RS09620 ^@ http://purl.uniprot.org/uniprot/A0A223MZ33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.|||Bacterial flagellum basal body|||Belongs to the FlgI family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. http://togogenome.org/gene/2025808:CCZ37_RS11200 ^@ http://purl.uniprot.org/uniprot/A0A223N0A7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2025808:CCZ37_RS00195 ^@ http://purl.uniprot.org/uniprot/A0A223MUH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS10615 ^@ http://purl.uniprot.org/uniprot/A0A223MZM2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The Rieske protein is a high potential 2Fe-2S protein.|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/2025808:CCZ37_RS10070 ^@ http://purl.uniprot.org/uniprot/A0A223MZD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/2025808:CCZ37_RS11105 ^@ http://purl.uniprot.org/uniprot/A0A223MZW1 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/2025808:CCZ37_RS10820 ^@ http://purl.uniprot.org/uniprot/A0A223MZR5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2025808:CCZ37_RS14270 ^@ http://purl.uniprot.org/uniprot/A0A223N1J6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell inner membrane|||Cell membrane|||Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). http://togogenome.org/gene/2025808:CCZ37_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A223MVF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/2025808:CCZ37_RS11425 ^@ http://purl.uniprot.org/uniprot/A0A223N009 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2025808:CCZ37_RS01105 ^@ http://purl.uniprot.org/uniprot/A0A223MUN8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase. http://togogenome.org/gene/2025808:CCZ37_RS02185 ^@ http://purl.uniprot.org/uniprot/A0A223MV71 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). http://togogenome.org/gene/2025808:CCZ37_RS12945 ^@ http://purl.uniprot.org/uniprot/A0A223N131 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiK family.|||Cytoplasm|||Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. http://togogenome.org/gene/2025808:CCZ37_RS00390 ^@ http://purl.uniprot.org/uniprot/A0A223N199 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP G family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A223MW17 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A223MVZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2025808:CCZ37_RS10775 ^@ http://purl.uniprot.org/uniprot/A0A223MZR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/2025808:CCZ37_RS08925 ^@ http://purl.uniprot.org/uniprot/A0A223MYR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmB/CycW/HelB family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/2025808:CCZ37_RS13295 ^@ http://purl.uniprot.org/uniprot/A0A223N167 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS09275 ^@ http://purl.uniprot.org/uniprot/A0A223MZ70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the FliF family.|||Membrane|||The M ring may be actively involved in energy transduction.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively. http://togogenome.org/gene/2025808:CCZ37_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A223MW77 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2025808:CCZ37_RS11685 ^@ http://purl.uniprot.org/uniprot/A0A223N049 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/2025808:CCZ37_RS01960 ^@ http://purl.uniprot.org/uniprot/A0A223MV17 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/2025808:CCZ37_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A223MV11 ^@ Similarity ^@ Belongs to the prokaryotic GSH synthase family. http://togogenome.org/gene/2025808:CCZ37_RS00335 ^@ http://purl.uniprot.org/uniprot/A0A223MV28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0761 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS10005 ^@ http://purl.uniprot.org/uniprot/A0A223MZA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.|||Cell membrane|||Homotetramer.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. http://togogenome.org/gene/2025808:CCZ37_RS08990 ^@ http://purl.uniprot.org/uniprot/A0A223MZA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/2025808:CCZ37_RS10150 ^@ http://purl.uniprot.org/uniprot/A0A223MZE6 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/2025808:CCZ37_RS09910 ^@ http://purl.uniprot.org/uniprot/A0A223MZR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/2025808:CCZ37_RS01520 ^@ http://purl.uniprot.org/uniprot/A0A223MUW8 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/2025808:CCZ37_RS02635 ^@ http://purl.uniprot.org/uniprot/A0A223MVL4 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/2025808:CCZ37_RS05410 ^@ http://purl.uniprot.org/uniprot/A0A223MX10 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.|||Binds 1 zinc ion per subunit.|||Transforms N(2)-succinylglutamate into succinate and glutamate. http://togogenome.org/gene/2025808:CCZ37_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A223MWF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell inner membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/2025808:CCZ37_RS06925 ^@ http://purl.uniprot.org/uniprot/A0A223MXN0 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/2025808:CCZ37_RS04970 ^@ http://purl.uniprot.org/uniprot/A0A223MWQ7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/2025808:CCZ37_RS09380 ^@ http://purl.uniprot.org/uniprot/A0A223MZ15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamC family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/2025808:CCZ37_RS09280 ^@ http://purl.uniprot.org/uniprot/A0A223MYZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family. http://togogenome.org/gene/2025808:CCZ37_RS10620 ^@ http://purl.uniprot.org/uniprot/A0A223MZX1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/2025808:CCZ37_RS00365 ^@ http://purl.uniprot.org/uniprot/A0A223MUJ7 ^@ Similarity ^@ Belongs to the HSP15 family. http://togogenome.org/gene/2025808:CCZ37_RS02425 ^@ http://purl.uniprot.org/uniprot/A0A223MVG7 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/2025808:CCZ37_RS14660 ^@ http://purl.uniprot.org/uniprot/A0A223N1S6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2025808:CCZ37_RS12795 ^@ http://purl.uniprot.org/uniprot/A0A223N108 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RlmJ family.|||Monomer.|||Specifically methylates the adenine in position 2030 of 23S rRNA. http://togogenome.org/gene/2025808:CCZ37_RS01050 ^@ http://purl.uniprot.org/uniprot/A0A223MUQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2025808:CCZ37_RS07040 ^@ http://purl.uniprot.org/uniprot/A0A223MXQ8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/2025808:CCZ37_RS04200 ^@ http://purl.uniprot.org/uniprot/A0A223MW59 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/2025808:CCZ37_RS13520 ^@ http://purl.uniprot.org/uniprot/A0A223N1C7 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/2025808:CCZ37_RS01605 ^@ http://purl.uniprot.org/uniprot/A0A223MUW1 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/2025808:CCZ37_RS00395 ^@ http://purl.uniprot.org/uniprot/A0A223MUD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP H family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS05245 ^@ http://purl.uniprot.org/uniprot/A0A223MWR0 ^@ Similarity ^@ Belongs to the elongation factor P family. http://togogenome.org/gene/2025808:CCZ37_RS01650 ^@ http://purl.uniprot.org/uniprot/A0A223MUW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/2025808:CCZ37_RS11165 ^@ http://purl.uniprot.org/uniprot/A0A223MZX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptC family.|||Cell inner membrane|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.|||Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.|||Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. http://togogenome.org/gene/2025808:CCZ37_RS10535 ^@ http://purl.uniprot.org/uniprot/A0A223MZL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/2025808:CCZ37_RS00380 ^@ http://purl.uniprot.org/uniprot/A0A223MUJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.|||Belongs to the GSP E family.|||Cell inner membrane http://togogenome.org/gene/2025808:CCZ37_RS00105 ^@ http://purl.uniprot.org/uniprot/A0A223MUF1 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/2025808:CCZ37_RS14580 ^@ http://purl.uniprot.org/uniprot/A0A223N2A6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2025808:CCZ37_RS00695 ^@ http://purl.uniprot.org/uniprot/A0A223MUK5 ^@ Similarity ^@ Belongs to the Dps family.