http://togogenome.org/gene/1550241:MA03_RS06220 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHZ3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/1550241:MA03_RS02065 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHU3 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1550241:MA03_RS07405 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLB1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1550241:MA03_RS06590 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJC3 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1550241:MA03_RS03460 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHZ4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1550241:MA03_RS00085 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKP3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1550241:MA03_RS01630 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGP0 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1550241:MA03_RS00795 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKR5 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/1550241:MA03_RS03335 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06470 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06875 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJE6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1550241:MA03_RS05910 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS08425 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1550241:MA03_RS07095 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI84 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/1550241:MA03_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00440 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKQ3 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/1550241:MA03_RS07010 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI36 ^@ Similarity ^@ Belongs to the UMP kinase family. http://togogenome.org/gene/1550241:MA03_RS05505 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI29 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/1550241:MA03_RS00465 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG26 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1550241:MA03_RS07345 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJK0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/1550241:MA03_RS04345 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK63 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/1550241:MA03_RS03930 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/1550241:MA03_RS06860 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL94 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS05520 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ22 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/1550241:MA03_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/1550241:MA03_RS02305 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHW8 ^@ Function ^@ Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). http://togogenome.org/gene/1550241:MA03_RS06530 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI28 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1550241:MA03_RS01875 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ19 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1550241:MA03_RS08190 ^@ http://purl.uniprot.org/uniprot/A0A0F7FKG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS02115 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGI1 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1550241:MA03_RS03975 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHI0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/1550241:MA03_RS07980 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLC7 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1550241:MA03_RS07715 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJP4 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS00845 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG20 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/1550241:MA03_RS01070 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE7 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1550241:MA03_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/1550241:MA03_RS08015 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLI0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/1550241:MA03_RS00335 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS00130 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGR5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/1550241:MA03_RS02760 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05875 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHS2 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/1550241:MA03_RS08105 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIK2 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/1550241:MA03_RS04535 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL29 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Membrane http://togogenome.org/gene/1550241:MA03_RS01560 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1550241:MA03_RS00550 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKQ7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1550241:MA03_RS07485 ^@ http://purl.uniprot.org/uniprot/A0A0F7FID2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/1550241:MA03_RS00350 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH64 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS08220 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/1550241:MA03_RS06660 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHZ9 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/1550241:MA03_RS06625 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL88 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS01620 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS07675 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJE3 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07450 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJL2 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1550241:MA03_RS03570 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH07 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1550241:MA03_RS08405 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJL8 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1550241:MA03_RS06750 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL91 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Belongs to the ribosomal protein L31e family. http://togogenome.org/gene/1550241:MA03_RS04655 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ69 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/1550241:MA03_RS05585 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL59 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS02385 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS05950 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/1550241:MA03_RS00235 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS08335 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIM7 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/1550241:MA03_RS03180 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKY7 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/1550241:MA03_RS04865 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIS3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS05915 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1550241:MA03_RS07670 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIB5 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ02 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/1550241:MA03_RS00890 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG24 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1550241:MA03_RS07015 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/1550241:MA03_RS02905 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHS5 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1550241:MA03_RS00585 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE4 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1550241:MA03_RS07490 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJL7 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/1550241:MA03_RS02675 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIQ9 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/1550241:MA03_RS00345 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJZ1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1550241:MA03_RS08080 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLD0 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/1550241:MA03_RS06525 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIE4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1550241:MA03_RS06710 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI04 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS00605 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00170 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFZ5 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/1550241:MA03_RS07045 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI42 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS07665 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJN7 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1550241:MA03_RS04490 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIX3 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/1550241:MA03_RS02690 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS08120 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLD1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/1550241:MA03_RS02685 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00850 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKR7 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/1550241:MA03_RS05770 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIZ8 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1550241:MA03_RS07785 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/1550241:MA03_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00400 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKQ2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1550241:MA03_RS02255 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS03030 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00120 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJM6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/1550241:MA03_RS01475 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHM9 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/1550241:MA03_RS05920 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS03120 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07910 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJG3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/1550241:MA03_RS02695 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS01655 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKU0 ^@ Cofactor ^@ Binds 4 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/1550241:MA03_RS00695 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS02510 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHY8 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1550241:MA03_RS00860 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/1550241:MA03_RS05115 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00385 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/1550241:MA03_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1550241:MA03_RS07005 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/1550241:MA03_RS08165 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJU9 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS00855 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHD5 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/1550241:MA03_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG89 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/1550241:MA03_RS00115 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/1550241:MA03_RS06295 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1550241:MA03_RS08205 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIV8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/1550241:MA03_RS02095 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHJ9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family. http://togogenome.org/gene/1550241:MA03_RS05060 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHJ4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS00330 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGU2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/1550241:MA03_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00200 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH45 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1550241:MA03_RS04745 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL35 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/1550241:MA03_RS00600 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH90 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/1550241:MA03_RS02600 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIU6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1550241:MA03_RS00410 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/1550241:MA03_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJE2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1550241:MA03_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHG9 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS02375 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00320 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1550241:MA03_RS08150 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIK7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1550241:MA03_RS07845 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJQ9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/1550241:MA03_RS07885 ^@ http://purl.uniprot.org/uniprot/A0A0F7FII0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/1550241:MA03_RS06430 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/1550241:MA03_RS07480 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLB3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/1550241:MA03_RS07050 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ13 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/1550241:MA03_RS05760 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIW3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1550241:MA03_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKP9 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/1550241:MA03_RS06840 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI56 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/1550241:MA03_RS04220 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHK3 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1550241:MA03_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIX2 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/1550241:MA03_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIR9 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1550241:MA03_RS05790 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL64 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1550241:MA03_RS00490 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJC7 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/1550241:MA03_RS03765 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHE9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/1550241:MA03_RS00700 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGT1 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1550241:MA03_RS04375 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07395 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ43 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1550241:MA03_RS04800 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06700 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJD0 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/1550241:MA03_RS05400 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL54 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1550241:MA03_RS07495 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00050 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIP0 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/1550241:MA03_RS00375 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG17 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/1550241:MA03_RS01950 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07060 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLA0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/1550241:MA03_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS01755 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS01955 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07455 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI92 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/1550241:MA03_RS01110 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK12 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/1550241:MA03_RS01005 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJP7 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1550241:MA03_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ66 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/1550241:MA03_RS00095 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/1550241:MA03_RS06855 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ49 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS06915 ^@ http://purl.uniprot.org/uniprot/A0A0F7FII2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1550241:MA03_RS00925 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJP0 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1550241:MA03_RS06815 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI13 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/1550241:MA03_RS00340 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1550241:MA03_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/1550241:MA03_RS00210 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFZ8 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/1550241:MA03_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1550241:MA03_RS07400 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS02560 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00355 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS00730 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK97 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/1550241:MA03_RS02260 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKQ9 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/1550241:MA03_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL71 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/1550241:MA03_RS05855 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/1550241:MA03_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI87 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/1550241:MA03_RS03140 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/1550241:MA03_RS07410 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1550241:MA03_RS03595 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05340 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS07815 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJF6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/1550241:MA03_RS06985 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/1550241:MA03_RS02555 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKW6 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1550241:MA03_RS01545 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGM8 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1550241:MA03_RS07420 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/1550241:MA03_RS04285 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS00025 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH29 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1550241:MA03_RS05870 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL66 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1550241:MA03_RS07990 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIE9 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1550241:MA03_RS07435 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLB2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1550241:MA03_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1550241:MA03_RS06565 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIF0 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1550241:MA03_RS01260 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHL4 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1550241:MA03_RS07630 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/1550241:MA03_RS02070 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ24 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/1550241:MA03_RS04350 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIA7 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/1550241:MA03_RS06270 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS07720 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/1550241:MA03_RS00620 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG80 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/1550241:MA03_RS06825 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIH3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/1550241:MA03_RS04330 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00555 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH86 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1550241:MA03_RS04055 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHI8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1550241:MA03_RS00575 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJN5 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/1550241:MA03_RS06645 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJB2 ^@ Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Heterodimer of a large and a small subunit. http://togogenome.org/gene/1550241:MA03_RS08460 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJM1 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1550241:MA03_RS03175 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGW0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Membrane http://togogenome.org/gene/1550241:MA03_RS03855 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05850 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHV9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/1550241:MA03_RS03285 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/1550241:MA03_RS05695 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL62 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS02680 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07725 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS05395 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05525 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHP3 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1550241:MA03_RS00775 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1550241:MA03_RS01435 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGN6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/1550241:MA03_RS04050 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00390 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1550241:MA03_RS07035 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJG2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1550241:MA03_RS06405 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI14 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/1550241:MA03_RS06540 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS08115 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJU2 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/1550241:MA03_RS07750 ^@ http://purl.uniprot.org/uniprot/A0A0F7FKG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/1550241:MA03_RS07745 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJP9 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. http://togogenome.org/gene/1550241:MA03_RS08155 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ65 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1550241:MA03_RS00915 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIL9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1550241:MA03_RS02140 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00225 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGS6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1550241:MA03_RS08255 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIL8 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/1550241:MA03_RS03005 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKY1 ^@ Function|||Similarity ^@ Belongs to the UPF0330 family.|||Possibly the antitoxin component of a toxin-antitoxin (TA) module. http://togogenome.org/gene/1550241:MA03_RS07855 ^@ http://purl.uniprot.org/uniprot/A0A0F7FID3 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/1550241:MA03_RS04845 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIG6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS01975 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06755 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI08 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/1550241:MA03_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL13 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/1550241:MA03_RS03985 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/1550241:MA03_RS08315 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK72 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/1550241:MA03_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHA9 ^@ Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS00110 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH35 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/1550241:MA03_RS05860 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLH1 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/1550241:MA03_RS05075 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS08160 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/1550241:MA03_RS06580 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL87 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1550241:MA03_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL14 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS00180 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKP5 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/1550241:MA03_RS02205 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHK5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1550241:MA03_RS03620 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH63 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/1550241:MA03_RS02875 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHS1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/1550241:MA03_RS08235 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIH2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1550241:MA03_RS00245 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKP7 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1550241:MA03_RS03915 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIG9 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/1550241:MA03_RS06600 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHE8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/1550241:MA03_RS05705 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ33 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/1550241:MA03_RS03865 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS00315 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH59 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/1550241:MA03_RS05880 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/1550241:MA03_RS00735 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG46 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1550241:MA03_RS04315 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS08350 ^@ http://purl.uniprot.org/uniprot/A0A0F7FII7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1550241:MA03_RS08310 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLD6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS01125 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKS4 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1550241:MA03_RS03185 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI77 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/1550241:MA03_RS03125 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06745 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJD3 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/1550241:MA03_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS01570 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK19 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1550241:MA03_RS05335 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL52 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1550241:MA03_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05865 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIW8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS06975 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJF5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS00425 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/1550241:MA03_RS07730 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/1550241:MA03_RS02940 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS04735 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLG5 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/1550241:MA03_RS08075 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/1550241:MA03_RS04040 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHA7 ^@ Similarity ^@ Belongs to the CTP synthase family. http://togogenome.org/gene/1550241:MA03_RS03220 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI78 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1550241:MA03_RS02570 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS04595 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIP6 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1550241:MA03_RS02660 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS08000 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIU0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1550241:MA03_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIY2 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1550241:MA03_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ56 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family. http://togogenome.org/gene/1550241:MA03_RS02340 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS02450 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHM3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/1550241:MA03_RS08210 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLD3 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1550241:MA03_RS00830 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG72 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1550241:MA03_RS07610 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIA9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1550241:MA03_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHU5 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/1550241:MA03_RS07895 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS07820 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIS1 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/1550241:MA03_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS08265 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJV9 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1550241:MA03_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH24 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS01145 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07415 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJB6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS05945 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Membrane http://togogenome.org/gene/1550241:MA03_RS04175 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH79 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1550241:MA03_RS07755 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ30 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/1550241:MA03_RS00815 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG15 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1550241:MA03_RS05895 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS01990 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGM5 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/1550241:MA03_RS02175 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07735 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIR2 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/1550241:MA03_RS05785 ^@ http://purl.uniprot.org/uniprot/A0A0F7FKA0 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS04925 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL40 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/1550241:MA03_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHV4 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/1550241:MA03_RS06550 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1550241:MA03_RS03015 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHU1 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/1550241:MA03_RS06145 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL73 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1550241:MA03_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS02155 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS04860 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS05305 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIR0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1550241:MA03_RS05265 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1550241:MA03_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS06965 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL97 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/1550241:MA03_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/1550241:MA03_RS06695 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS04020 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIW5 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1550241:MA03_RS04425 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHC1 ^@ Function ^@ Catalyzes the synthesis of GMP from XMP. http://togogenome.org/gene/1550241:MA03_RS04245 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL51 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/1550241:MA03_RS01370 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKT2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer and homodimer. http://togogenome.org/gene/1550241:MA03_RS03400 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIA6 ^@ Function|||Similarity ^@ Belongs to the LuxC family.|||LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase. http://togogenome.org/gene/1550241:MA03_RS04510 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHC2 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1550241:MA03_RS01760 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHG7 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1550241:MA03_RS05955 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1550241:MA03_RS02545 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHZ2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1550241:MA03_RS00140 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG27 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1550241:MA03_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJR7 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1550241:MA03_RS03250 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1550241:MA03_RS04545 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL61 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/1550241:MA03_RS00230 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1550241:MA03_RS01270 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHA5 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1550241:MA03_RS02335 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS02610 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKW7 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. http://togogenome.org/gene/1550241:MA03_RS00100 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIK3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1550241:MA03_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS06865 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIH6 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1550241:MA03_RS01625 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS07685 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS05930 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI73 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS06765 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJ41 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1550241:MA03_RS02315 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHL5 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1550241:MA03_RS05130 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIV5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1550241:MA03_RS00195 ^@ http://purl.uniprot.org/uniprot/A0A0F7FFT7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1550241:MA03_RS07475 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIN9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/1550241:MA03_RS00160 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH40 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/1550241:MA03_RS04095 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH72 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1550241:MA03_RS05535 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS03050 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGZ5 ^@ Similarity ^@ Belongs to the monomethylamine methyltransferase family. http://togogenome.org/gene/1550241:MA03_RS00185 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS08455 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1550241:MA03_RS02150 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS02380 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1550241:MA03_RS00420 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG22 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1550241:MA03_RS07880 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIS6 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/1550241:MA03_RS06780 ^@ http://purl.uniprot.org/uniprot/A0A0F7FKB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1550241:MA03_RS07765 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/1550241:MA03_RS04555 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS05510 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHS4 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1550241:MA03_RS08045 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIU5 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/1550241:MA03_RS06850 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI16 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/1550241:MA03_RS04495 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHM4 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/1550241:MA03_RS03760 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLF9 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1550241:MA03_RS06515 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/1550241:MA03_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHJ7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS01055 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKS2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1550241:MA03_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07995 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJH2 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1550241:MA03_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A0F7CLE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1550241:MA03_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A0F7FH56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A0F7FI82 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/1550241:MA03_RS06570 ^@ http://purl.uniprot.org/uniprot/A0A0F7FKB1 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/1550241:MA03_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A0F7FGS0 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/1550241:MA03_RS05180 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHI2 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/1550241:MA03_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS00825 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS07465 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJC1 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/1550241:MA03_RS07330 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIN0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/1550241:MA03_RS00500 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKQ5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1550241:MA03_RS06400 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1550241:MA03_RS04875 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHH2 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1550241:MA03_RS03495 ^@ http://purl.uniprot.org/uniprot/A0A0F7FK48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1550241:MA03_RS03645 ^@ http://purl.uniprot.org/uniprot/A0A0F7FID5 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/1550241:MA03_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHF2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1550241:MA03_RS01175 ^@ http://purl.uniprot.org/uniprot/A0A0F7FG49 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/1550241:MA03_RS06195 ^@ http://purl.uniprot.org/uniprot/A0A0F7CL75 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/1550241:MA03_RS07740 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIG5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1550241:MA03_RS06605 ^@ http://purl.uniprot.org/uniprot/A0A0F7FIF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1550241:MA03_RS04755 ^@ http://purl.uniprot.org/uniprot/A0A0F7FHP8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1550241:MA03_RS08280 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/1550241:MA03_RS00270 ^@ http://purl.uniprot.org/uniprot/A0A0F7CKP8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1550241:MA03_RS06420 ^@ http://purl.uniprot.org/uniprot/A0A0F7FJA3 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily.