http://togogenome.org/gene/1307763:L21SP4_RS04795 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFQ4 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1307763:L21SP4_RS11700 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJJ0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/1307763:L21SP4_RS02580 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS06550 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE45 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS06080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDE1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00065 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAM5 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/1307763:L21SP4_RS05760 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDM6 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/1307763:L21SP4_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHH6 ^@ Caution|||Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/1307763:L21SP4_RS10645 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMR8 ^@ Function ^@ Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1307763:L21SP4_RS05415 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS07165 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE26 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/1307763:L21SP4_RS10275 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMJ6 ^@ Similarity ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily. http://togogenome.org/gene/1307763:L21SP4_RS06190 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1307763:L21SP4_RS08030 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL76 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/1307763:L21SP4_RS08900 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFD9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS11635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGX1 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS06760 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDU8 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1307763:L21SP4_RS07640 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ53 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. HflK subfamily. http://togogenome.org/gene/1307763:L21SP4_RS02585 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS02485 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS13210 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECQ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS11390 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGS2 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1307763:L21SP4_RS04010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC88 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS06715 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGS0 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07240 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE42 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS04655 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED24 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/1307763:L21SP4_RS05125 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECW5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS07050 ^@ http://purl.uniprot.org/uniprot/A0A0G3EED2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/1307763:L21SP4_RS07110 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIP8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1307763:L21SP4_RS04135 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS11035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGK6 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS06200 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS02155 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS01290 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHA9 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS03620 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS07125 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEE3 ^@ Similarity|||Subunit ^@ Belongs to the FPG family.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS11090 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMY3 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/1307763:L21SP4_RS09300 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06905 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1307763:L21SP4_RS01970 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB14 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1307763:L21SP4_RS01020 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAK4 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/1307763:L21SP4_RS02865 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NqrA family.|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1307763:L21SP4_RS03895 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIR9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1307763:L21SP4_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A0G3EER5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS02430 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBU2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/1307763:L21SP4_RS08630 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/1307763:L21SP4_RS01765 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAX3 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS03635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/1307763:L21SP4_RS06255 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGI7 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/1307763:L21SP4_RS02735 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC26 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS01230 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1307763:L21SP4_RS13050 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFX9 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1307763:L21SP4_RS08450 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1307763:L21SP4_RS10685 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS04900 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED59 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS02165 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1307763:L21SP4_RS08830 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF11 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/1307763:L21SP4_RS09235 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF68 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/1307763:L21SP4_RS00860 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0719 family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS00145 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/1307763:L21SP4_RS07960 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJB2 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/1307763:L21SP4_RS03750 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGU8 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1307763:L21SP4_RS00375 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDC0 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS05785 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDN0 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/1307763:L21SP4_RS00200 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAP9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1307763:L21SP4_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS03460 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECF3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1307763:L21SP4_RS08335 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/1307763:L21SP4_RS05470 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJS1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1307763:L21SP4_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEB3 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/1307763:L21SP4_RS09570 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK51 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/1307763:L21SP4_RS08425 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/1307763:L21SP4_RS02915 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/1307763:L21SP4_RS10170 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMH4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/1307763:L21SP4_RS00535 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGY7 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/1307763:L21SP4_RS12170 ^@ http://purl.uniprot.org/uniprot/A0A0G3ENI5 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/1307763:L21SP4_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDK7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/1307763:L21SP4_RS04560 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECF9 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07710 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS05395 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG43 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/1307763:L21SP4_RS02630 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC08 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS09685 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFS6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1307763:L21SP4_RS11640 ^@ http://purl.uniprot.org/uniprot/A0A0G3EN76 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS02840 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC45 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrF family.|||Binds 1 [2Fe-2S] cluster.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. http://togogenome.org/gene/1307763:L21SP4_RS08275 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEN2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1307763:L21SP4_RS06900 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1307763:L21SP4_RS07425 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIV5 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/1307763:L21SP4_RS05485 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS03680 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS04535 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFL1 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS11410 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJE3 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS08700 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS05030 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJD0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS06070 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS04320 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFG7 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1307763:L21SP4_RS10230 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKN7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1307763:L21SP4_RS10695 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1307763:L21SP4_RS09275 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08125 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF00 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1307763:L21SP4_RS09825 ^@ http://purl.uniprot.org/uniprot/A0A0G3EM46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/1307763:L21SP4_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECP7 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1307763:L21SP4_RS09900 ^@ http://purl.uniprot.org/uniprot/A0A0G3EII6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1307763:L21SP4_RS11175 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10265 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIU8 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/1307763:L21SP4_RS06250 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDH3 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/1307763:L21SP4_RS07615 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05080 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/1307763:L21SP4_RS03920 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIS2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/1307763:L21SP4_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIK2 ^@ Similarity ^@ Belongs to the myoviridae tail sheath protein family. http://togogenome.org/gene/1307763:L21SP4_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1307763:L21SP4_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIY8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS07035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIN9 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1307763:L21SP4_RS10510 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS09935 ^@ http://purl.uniprot.org/uniprot/A0A0G3EM72 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS11395 ^@ http://purl.uniprot.org/uniprot/A0A0G3EN29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK45 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00545 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAC4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS10415 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKS5 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/1307763:L21SP4_RS08090 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEK7 ^@ Similarity ^@ Belongs to the ketol-acid reductoisomerase family. http://togogenome.org/gene/1307763:L21SP4_RS05230 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS01300 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS06745 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE82 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/1307763:L21SP4_RS11985 ^@ http://purl.uniprot.org/uniprot/A0A0G3ENF2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS01450 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAR6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1307763:L21SP4_RS10965 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10535 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMP6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS06005 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK12 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07200 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEF1 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS06955 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKG6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS04205 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIX6 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/1307763:L21SP4_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBN9 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/1307763:L21SP4_RS07495 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKS7 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/1307763:L21SP4_RS10325 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMK6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/1307763:L21SP4_RS03050 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBQ8 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307763:L21SP4_RS04880 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS11895 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGQ3 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1307763:L21SP4_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGF5 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/1307763:L21SP4_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/1307763:L21SP4_RS06185 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1307763:L21SP4_RS06730 ^@ http://purl.uniprot.org/uniprot/A0A0G3EII4 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS01035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1307763:L21SP4_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFA4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/1307763:L21SP4_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A0G3EA59 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/1307763:L21SP4_RS03190 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBT8 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1307763:L21SP4_RS12230 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFE8 ^@ Similarity ^@ Belongs to the rubredoxin family. http://togogenome.org/gene/1307763:L21SP4_RS05025 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED80 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHJ4 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/1307763:L21SP4_RS06950 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEB7 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).|||Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS01130 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS09415 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELW5 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07610 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS08550 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1307763:L21SP4_RS09355 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFM0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307763:L21SP4_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.|||Cytoplasm|||Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity. http://togogenome.org/gene/1307763:L21SP4_RS08110 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJE4 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/1307763:L21SP4_RS08600 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF80 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/1307763:L21SP4_RS04110 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH19 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/1307763:L21SP4_RS00335 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGV1 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/1307763:L21SP4_RS03045 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/1307763:L21SP4_RS08240 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJG4 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS00355 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAS3 ^@ Cofactor ^@ Binds 2 magnesium ions per subunit. http://togogenome.org/gene/1307763:L21SP4_RS04575 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ33 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS09940 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS01120 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1307763:L21SP4_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAM9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS11550 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGI9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1307763:L21SP4_RS08315 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS05440 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS00030 ^@ http://purl.uniprot.org/uniprot/A0A0G3E9X6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/1307763:L21SP4_RS12375 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGK5 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS08270 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJG7 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/1307763:L21SP4_RS03535 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS04800 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED42 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/1307763:L21SP4_RS10805 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Forms a 24-polypeptide structural core with octahedral symmetry.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/1307763:L21SP4_RS09510 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the etk/wzc family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS01520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAT0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/1307763:L21SP4_RS11600 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/1307763:L21SP4_RS03955 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS04285 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08650 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/1307763:L21SP4_RS10105 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFQ0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. http://togogenome.org/gene/1307763:L21SP4_RS07680 ^@ http://purl.uniprot.org/uniprot/A0A0G3EET9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS02330 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHT8 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/1307763:L21SP4_RS08445 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1307763:L21SP4_RS12080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJR8 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1307763:L21SP4_RS10335 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFY9 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/1307763:L21SP4_RS12400 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFV0 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS06800 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS03885 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF56 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/1307763:L21SP4_RS04230 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIY1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS10710 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG38 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/1307763:L21SP4_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIT3 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1307763:L21SP4_RS00525 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDE0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1307763:L21SP4_RS11870 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGP8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10240 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIU3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1307763:L21SP4_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIB4 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/1307763:L21SP4_RS07770 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEH0 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1307763:L21SP4_RS01975 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE39 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS10870 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL02 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/1307763:L21SP4_RS10720 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/1307763:L21SP4_RS00400 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS05020 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFU4 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1307763:L21SP4_RS00680 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH13 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS02490 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Cell inner membrane|||Cell membrane|||Membrane|||Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine. http://togogenome.org/gene/1307763:L21SP4_RS05700 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307763:L21SP4_RS00110 ^@ http://purl.uniprot.org/uniprot/A0A0G3EA45 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307763:L21SP4_RS03770 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/1307763:L21SP4_RS08940 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS07095 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGZ8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS04965 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS05275 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDF9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/1307763:L21SP4_RS01180 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDP5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS00440 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGF0 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/1307763:L21SP4_RS00710 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/1307763:L21SP4_RS12095 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS03740 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS10660 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS02605 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC04 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1307763:L21SP4_RS05335 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS09050 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFG0 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1307763:L21SP4_RS02765 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10570 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKV3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1307763:L21SP4_RS09495 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/1307763:L21SP4_RS03705 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIP7 ^@ Cofactor|||Similarity ^@ Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/1307763:L21SP4_RS09010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS05410 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1307763:L21SP4_RS05615 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED52 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/1307763:L21SP4_RS08715 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHW5 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1307763:L21SP4_RS06260 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDZ2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/1307763:L21SP4_RS03755 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC14 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1307763:L21SP4_RS09230 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/1307763:L21SP4_RS00325 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDB1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1307763:L21SP4_RS09905 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/1307763:L21SP4_RS01190 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH97 ^@ Similarity ^@ Belongs to the DNA photolyase family. http://togogenome.org/gene/1307763:L21SP4_RS08465 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/1307763:L21SP4_RS12480 ^@ http://purl.uniprot.org/uniprot/A0A0G3EM27 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1307763:L21SP4_RS00115 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED83 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307763:L21SP4_RS00105 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEY8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307763:L21SP4_RS06770 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE87 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/1307763:L21SP4_RS08320 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJH5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1307763:L21SP4_RS04170 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS04060 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH09 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/1307763:L21SP4_RS00390 ^@ http://purl.uniprot.org/uniprot/A0A0G3EA98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS04920 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/1307763:L21SP4_RS07705 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEU2 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1307763:L21SP4_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS03855 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF49 ^@ Similarity ^@ Belongs to the HPrK/P family. http://togogenome.org/gene/1307763:L21SP4_RS04985 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHF6 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBJ0 ^@ Function|||Similarity ^@ Belongs to the phenylacetyl-CoA ligase family.|||Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). http://togogenome.org/gene/1307763:L21SP4_RS05360 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHS5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS04235 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS03020 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGH2 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1307763:L21SP4_RS02600 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEL6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1307763:L21SP4_RS02290 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/1307763:L21SP4_RS03175 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS02750 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10075 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS13250 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1307763:L21SP4_RS04020 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF85 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/1307763:L21SP4_RS03185 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIF6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. http://togogenome.org/gene/1307763:L21SP4_RS07630 ^@ http://purl.uniprot.org/uniprot/A0A0G3EET2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. HflK subfamily. http://togogenome.org/gene/1307763:L21SP4_RS01755 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHI1 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS00315 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF10 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/1307763:L21SP4_RS00670 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDF7 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS08520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/1307763:L21SP4_RS05065 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECR2 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/1307763:L21SP4_RS00915 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05060 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1307763:L21SP4_RS06240 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS00185 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEZ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGA3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS05320 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG33 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/1307763:L21SP4_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFH0 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/1307763:L21SP4_RS08130 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06740 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGS8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1307763:L21SP4_RS02850 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08385 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF41 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1307763:L21SP4_RS06145 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI63 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS10940 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMW1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/1307763:L21SP4_RS02210 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHR0 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/1307763:L21SP4_RS01685 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS12165 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH72 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/1307763:L21SP4_RS08325 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1307763:L21SP4_RS04365 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECB9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1307763:L21SP4_RS10210 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIT8 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/1307763:L21SP4_RS03520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS04770 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFQ1 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/1307763:L21SP4_RS02980 ^@ http://purl.uniprot.org/uniprot/A0A0G3EER8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08765 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05830 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS08080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/1307763:L21SP4_RS06935 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS08680 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJP0 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/1307763:L21SP4_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECS5 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1307763:L21SP4_RS00125 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGR6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1307763:L21SP4_RS12205 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGY2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1307763:L21SP4_RS02170 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1307763:L21SP4_RS05900 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI17 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/1307763:L21SP4_RS08875 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFD5 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/1307763:L21SP4_RS03465 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LysR transcriptional regulatory family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS09325 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFL4 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1307763:L21SP4_RS03800 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGV9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/1307763:L21SP4_RS08330 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1307763:L21SP4_RS06170 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI68 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS05390 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED20 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/1307763:L21SP4_RS05590 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS00345 ^@ http://purl.uniprot.org/uniprot/A0A0G3EA89 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/1307763:L21SP4_RS07845 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEH7 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1307763:L21SP4_RS10185 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/1307763:L21SP4_RS03865 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/1307763:L21SP4_RS09870 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFK3 ^@ Similarity ^@ Belongs to the glycosyltransferase 1 family. http://togogenome.org/gene/1307763:L21SP4_RS07410 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH66 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1307763:L21SP4_RS06960 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIM9 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS00220 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED97 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS05770 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHZ6 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/1307763:L21SP4_RS08045 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHJ8 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS07605 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS05775 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED99 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/1307763:L21SP4_RS03250 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/1307763:L21SP4_RS02860 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1307763:L21SP4_RS01015 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFD1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1307763:L21SP4_RS07850 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHH7 ^@ Similarity ^@ Belongs to the UPF0751 family. http://togogenome.org/gene/1307763:L21SP4_RS07350 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKP4 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/1307763:L21SP4_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB56 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1307763:L21SP4_RS08185 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELA7 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/1307763:L21SP4_RS04895 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/1307763:L21SP4_RS08010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08490 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHS3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS06660 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1307763:L21SP4_RS06475 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDP6 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/1307763:L21SP4_RS03825 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS02740 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI69 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS09285 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK13 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307763:L21SP4_RS10080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFP7 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1307763:L21SP4_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF13 ^@ Subcellular Location Annotation ^@ Periplasm http://togogenome.org/gene/1307763:L21SP4_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJM2 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/1307763:L21SP4_RS08910 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJT8 ^@ Similarity ^@ Belongs to the alkaline phosphatase family. http://togogenome.org/gene/1307763:L21SP4_RS08980 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS02525 ^@ http://purl.uniprot.org/uniprot/A0A0G3EED7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1307763:L21SP4_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGA6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDE4 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/1307763:L21SP4_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/1307763:L21SP4_RS01155 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDP1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1307763:L21SP4_RS11935 ^@ http://purl.uniprot.org/uniprot/A0A0G3ENE0 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00060 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS00280 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS02315 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB77 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS01985 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHL1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/1307763:L21SP4_RS04845 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECL1 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. http://togogenome.org/gene/1307763:L21SP4_RS08855 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF15 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS01825 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAY6 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07155 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1307763:L21SP4_RS07235 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIR4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 65 family. http://togogenome.org/gene/1307763:L21SP4_RS09110 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF61 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/1307763:L21SP4_RS11345 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGE7 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS07560 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS00035 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS09750 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS02400 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS09440 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELX1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/1307763:L21SP4_RS01025 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDM2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/1307763:L21SP4_RS08730 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJQ0 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/1307763:L21SP4_RS08005 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1307763:L21SP4_RS10775 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKY4 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07955 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL63 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1307763:L21SP4_RS05690 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJV9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307763:L21SP4_RS08355 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1307763:L21SP4_RS06980 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08375 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEP7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1307763:L21SP4_RS05180 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS07080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKI8 ^@ Function|||Similarity ^@ Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/1307763:L21SP4_RS12505 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFU7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS08575 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/1307763:L21SP4_RS12620 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGM8 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS07885 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL47 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1307763:L21SP4_RS08290 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELC9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1307763:L21SP4_RS11425 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELB5 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1307763:L21SP4_RS00565 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAC9 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1307763:L21SP4_RS09045 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI20 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/1307763:L21SP4_RS06710 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDU0 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS04890 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHD8 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/1307763:L21SP4_RS02695 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBJ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1307763:L21SP4_RS05790 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJX9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/1307763:L21SP4_RS09545 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK46 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/1307763:L21SP4_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05365 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED16 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1307763:L21SP4_RS13150 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS07435 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/1307763:L21SP4_RS06805 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIK0 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/1307763:L21SP4_RS08285 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1307763:L21SP4_RS05035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS00920 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAJ3 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/1307763:L21SP4_RS01480 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06225 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS12215 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAV5 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS02140 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1307763:L21SP4_RS05000 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED77 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS09240 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF90 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS04065 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC65 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00120 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAN3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/1307763:L21SP4_RS01940 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10070 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS00075 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEY5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1307763:L21SP4_RS08365 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELE3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1307763:L21SP4_RS07860 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL43 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/1307763:L21SP4_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIG3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 65 family. http://togogenome.org/gene/1307763:L21SP4_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECL7 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07260 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE46 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS01315 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS08660 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJN5 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/1307763:L21SP4_RS02395 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB94 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1307763:L21SP4_RS08675 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELJ0 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS02800 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBL4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/1307763:L21SP4_RS11900 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJN3 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/1307763:L21SP4_RS08625 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS01885 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/1307763:L21SP4_RS06965 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDY5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/1307763:L21SP4_RS00130 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/1307763:L21SP4_RS08950 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFE6 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/1307763:L21SP4_RS11950 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJP3 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/1307763:L21SP4_RS07935 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJA9 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1307763:L21SP4_RS11565 ^@ http://purl.uniprot.org/uniprot/A0A0G3EN59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05555 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS11465 ^@ http://purl.uniprot.org/uniprot/A0A0G3EN40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/1307763:L21SP4_RS04155 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS08360 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS07750 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHG2 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1307763:L21SP4_RS00840 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAI2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/1307763:L21SP4_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK27 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307763:L21SP4_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIP1 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/1307763:L21SP4_RS10030 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0014 family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS10740 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGF1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/1307763:L21SP4_RS00135 ^@ http://purl.uniprot.org/uniprot/A0A0G3EA49 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS10600 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKV7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1307763:L21SP4_RS08020 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHJ5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.|||Binds 1 NADP(+) per subunit.|||Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.|||Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.|||Homopentamer. http://togogenome.org/gene/1307763:L21SP4_RS05795 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1307763:L21SP4_RS07625 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHE0 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1307763:L21SP4_RS07160 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIQ5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1307763:L21SP4_RS03015 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS11360 ^@ http://purl.uniprot.org/uniprot/A0A0G3EN22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol monophosphatase superfamily. CysQ family.|||Cell membrane|||Converts adenosine-3',5'-bisphosphate (PAP) to AMP. http://togogenome.org/gene/1307763:L21SP4_RS00805 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1307763:L21SP4_RS02175 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE79 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/1307763:L21SP4_RS02855 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBM2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrC family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1307763:L21SP4_RS10155 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFW1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1307763:L21SP4_RS12075 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGT9 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/1307763:L21SP4_RS04980 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJB6 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS09035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJW1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS10420 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG00 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/1307763:L21SP4_RS11960 ^@ http://purl.uniprot.org/uniprot/A0A0G3ENE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS02940 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC61 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/1307763:L21SP4_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAU7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1307763:L21SP4_RS09210 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS09565 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS02520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBB8 ^@ Similarity ^@ Belongs to the NAD synthetase family. http://togogenome.org/gene/1307763:L21SP4_RS05670 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHX8 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/1307763:L21SP4_RS01175 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/1307763:L21SP4_RS05130 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. http://togogenome.org/gene/1307763:L21SP4_RS07105 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1307763:L21SP4_RS08345 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1307763:L21SP4_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBB9 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/1307763:L21SP4_RS05215 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1307763:L21SP4_RS00425 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAT6 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/1307763:L21SP4_RS07135 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1307763:L21SP4_RS11455 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECK2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/1307763:L21SP4_RS08390 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1307763:L21SP4_RS05495 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJS7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS06930 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. http://togogenome.org/gene/1307763:L21SP4_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBZ8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS02495 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBB1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00770 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDI0 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS10715 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS04035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OadG family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS10345 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG80 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1307763:L21SP4_RS09850 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFV0 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS01285 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB76 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS07015 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDZ6 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1307763:L21SP4_RS10355 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS09200 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFI6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1307763:L21SP4_RS11385 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the encapsulin family. Family 1 subfamily.|||Encapsulin nanocompartment http://togogenome.org/gene/1307763:L21SP4_RS02935 ^@ http://purl.uniprot.org/uniprot/A0A0G3EER1 ^@ Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. http://togogenome.org/gene/1307763:L21SP4_RS03870 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGX5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/1307763:L21SP4_RS05780 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG98 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/1307763:L21SP4_RS03500 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEY9 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1307763:L21SP4_RS08340 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELD9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/1307763:L21SP4_RS08405 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1307763:L21SP4_RS09330 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELV0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00515 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/1307763:L21SP4_RS12090 ^@ http://purl.uniprot.org/uniprot/A0A0G3ENH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGV4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1307763:L21SP4_RS09350 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS05915 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS02440 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG18 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1307763:L21SP4_RS03080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS05450 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJU8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/1307763:L21SP4_RS03530 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECG7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1307763:L21SP4_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBR9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBZ4 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/1307763:L21SP4_RS10665 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGD7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1307763:L21SP4_RS07045 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGY8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/1307763:L21SP4_RS07420 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKQ9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS07635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL04 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/1307763:L21SP4_RS06515 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS02480 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBU8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1307763:L21SP4_RS06885 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIL4 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/1307763:L21SP4_RS07255 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIR8 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS00150 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS08205 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF12 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/1307763:L21SP4_RS08455 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHR7 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1307763:L21SP4_RS07785 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS12140 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH67 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS02845 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1307763:L21SP4_RS02320 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEA9 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307763:L21SP4_RS08305 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHN5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS08935 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJU3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1307763:L21SP4_RS10060 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIL7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1307763:L21SP4_RS08655 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/1307763:L21SP4_RS06915 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDX5 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1307763:L21SP4_RS06385 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK66 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/1307763:L21SP4_RS09540 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELZ2 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1307763:L21SP4_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GmhB family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS08120 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06920 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGW3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1307763:L21SP4_RS08480 ^@ http://purl.uniprot.org/uniprot/A0A0G3EER3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1307763:L21SP4_RS02570 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBC7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/1307763:L21SP4_RS03715 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGU2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS04765 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECJ5 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/1307763:L21SP4_RS08380 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHQ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1307763:L21SP4_RS05825 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI05 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/1307763:L21SP4_RS08695 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFA1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS11295 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06630 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKA7 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS00985 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS01445 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1307763:L21SP4_RS07100 ^@ http://purl.uniprot.org/uniprot/A0A0G3EED9 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1307763:L21SP4_RS03830 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS09975 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFM4 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/1307763:L21SP4_RS03470 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/1307763:L21SP4_RS10125 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKF0 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS05310 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHR6 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1307763:L21SP4_RS12280 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS06755 ^@ http://purl.uniprot.org/uniprot/A0A0G3EII9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1307763:L21SP4_RS01700 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDY4 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1307763:L21SP4_RS05675 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED60 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS06795 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE92 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/1307763:L21SP4_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP G family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS00830 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05185 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECY4 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/1307763:L21SP4_RS10855 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ32 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1307763:L21SP4_RS09375 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFB8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/1307763:L21SP4_RS07285 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/1307763:L21SP4_RS11350 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJC9 ^@ Caution|||Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS09500 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFE2 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1307763:L21SP4_RS11450 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS04750 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED34 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS01930 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE29 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1307763:L21SP4_RS04150 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECS7 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1307763:L21SP4_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1307763:L21SP4_RS09895 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFK8 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/1307763:L21SP4_RS09890 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKA6 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1307763:L21SP4_RS04435 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH77 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS11020 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL33 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1307763:L21SP4_RS02420 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBA0 ^@ Function|||Similarity ^@ Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/1307763:L21SP4_RS10405 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG88 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1307763:L21SP4_RS06910 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1307763:L21SP4_RS09600 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFF8 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1307763:L21SP4_RS07925 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEX4 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/1307763:L21SP4_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJN2 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS07430 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE81 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307763:L21SP4_RS10235 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFX4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1307763:L21SP4_RS08885 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJT2 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/1307763:L21SP4_RS06835 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDW0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1307763:L21SP4_RS07675 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS07150 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS00010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/1307763:L21SP4_RS08230 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF16 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00825 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB02 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1307763:L21SP4_RS02130 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBM3 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP K family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS11845 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGP2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the KduI family.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. http://togogenome.org/gene/1307763:L21SP4_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECK1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/1307763:L21SP4_RS08620 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS10280 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKP7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/1307763:L21SP4_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIZ8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS01925 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB08 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS09970 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307763:L21SP4_RS00520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1307763:L21SP4_RS08035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJC8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1307763:L21SP4_RS10800 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKY9 ^@ Function ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/1307763:L21SP4_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/1307763:L21SP4_RS09070 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFG4 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/1307763:L21SP4_RS08435 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1307763:L21SP4_RS08720 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJN0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS02610 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI48 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1307763:L21SP4_RS05145 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHN3 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/1307763:L21SP4_RS11355 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS08785 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS02790 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI79 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1307763:L21SP4_RS08235 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELB8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS02700 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/1307763:L21SP4_RS08475 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJJ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1307763:L21SP4_RS02905 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1307763:L21SP4_RS09060 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF52 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1307763:L21SP4_RS12635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH54 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB89 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/1307763:L21SP4_RS07700 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHF5 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/1307763:L21SP4_RS01395 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFI9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1307763:L21SP4_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS07265 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH36 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS06010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI33 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS08085 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1307763:L21SP4_RS10085 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIM3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS05385 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHS9 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307763:L21SP4_RS05715 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJW3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307763:L21SP4_RS05010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHG3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS09390 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS08300 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEN6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1307763:L21SP4_RS02010 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHL6 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS08770 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELK8 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/1307763:L21SP4_RS01690 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFP8 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS05055 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS09925 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIJ1 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1307763:L21SP4_RS10670 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1307763:L21SP4_RS07985 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH10 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1307763:L21SP4_RS08075 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1307763:L21SP4_RS04080 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS01650 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDX6 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307763:L21SP4_RS06895 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1307763:L21SP4_RS07365 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH56 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/1307763:L21SP4_RS10955 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS09860 ^@ http://purl.uniprot.org/uniprot/A0A0G3EM53 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily. http://togogenome.org/gene/1307763:L21SP4_RS00665 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAF5 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS10565 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS01500 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDU5 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1307763:L21SP4_RS04735 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHB5 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1307763:L21SP4_RS09065 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI25 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1307763:L21SP4_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A0G3EED3 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/1307763:L21SP4_RS09910 ^@ http://purl.uniprot.org/uniprot/A0A0G3EM66 ^@ Function ^@ The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. http://togogenome.org/gene/1307763:L21SP4_RS10090 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFY7 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS07065 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE05 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/1307763:L21SP4_RS07290 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH40 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS04360 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH65 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/1307763:L21SP4_RS02560 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHY5 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS01125 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDN6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1307763:L21SP4_RS02035 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHM0 ^@ Similarity ^@ Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/1307763:L21SP4_RS00700 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH18 ^@ Similarity ^@ Belongs to the XFP family. http://togogenome.org/gene/1307763:L21SP4_RS12600 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFV0 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/1307763:L21SP4_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A0G3EC77 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS06830 ^@ http://purl.uniprot.org/uniprot/A0A0G3EIK4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1307763:L21SP4_RS07790 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ82 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS02385 ^@ http://purl.uniprot.org/uniprot/A0A0G3EHU9 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS02065 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Homodimer.|||Monomer.|||Secreted http://togogenome.org/gene/1307763:L21SP4_RS05930 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI22 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1307763:L21SP4_RS10455 ^@ http://purl.uniprot.org/uniprot/A0A0G3EMN2 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/1307763:L21SP4_RS01160 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/1307763:L21SP4_RS01980 ^@ http://purl.uniprot.org/uniprot/A0A0G3EBJ8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1307763:L21SP4_RS01005 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1307763:L21SP4_RS00005 ^@ http://purl.uniprot.org/uniprot/A0A0G3ED07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/1307763:L21SP4_RS10765 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGF6 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS08000 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEY4 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/1307763:L21SP4_RS11965 ^@ http://purl.uniprot.org/uniprot/A0A0G3ELK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS11475 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1307763:L21SP4_RS02150 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE73 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/1307763:L21SP4_RS01165 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH94 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1307763:L21SP4_RS01170 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFF5 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/1307763:L21SP4_RS08105 ^@ http://purl.uniprot.org/uniprot/A0A0G3EL91 ^@ Similarity ^@ Belongs to the peptidase S24 family. http://togogenome.org/gene/1307763:L21SP4_RS00740 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAG7 ^@ Similarity ^@ Belongs to the MlaA family. http://togogenome.org/gene/1307763:L21SP4_RS07245 ^@ http://purl.uniprot.org/uniprot/A0A0G3EH28 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1307763:L21SP4_RS11555 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJG8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/1307763:L21SP4_RS00540 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF50 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1307763:L21SP4_RS00730 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05150 ^@ http://purl.uniprot.org/uniprot/A0A0G3ECX1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1307763:L21SP4_RS08310 ^@ http://purl.uniprot.org/uniprot/A0A0G3EF27 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1307763:L21SP4_RS04835 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJ83 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1307763:L21SP4_RS05085 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS05165 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDE9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/1307763:L21SP4_RS07180 ^@ http://purl.uniprot.org/uniprot/A0A0G3EKK7 ^@ Caution|||Function|||Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.|||Catalyzes the biosynthesis of agmatine from arginine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS10520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG13 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS01295 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFH4 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307763:L21SP4_RS11480 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJF5 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1307763:L21SP4_RS10900 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG67 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/1307763:L21SP4_RS00395 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDS7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1307763:L21SP4_RS01045 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAK7 ^@ Similarity ^@ Belongs to the HipA Ser/Thr kinase family. http://togogenome.org/gene/1307763:L21SP4_RS05705 ^@ http://purl.uniprot.org/uniprot/A0A0G3EG85 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS02635 ^@ http://purl.uniprot.org/uniprot/A0A0G3EI53 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. http://togogenome.org/gene/1307763:L21SP4_RS05420 ^@ http://purl.uniprot.org/uniprot/A0A0G3EDH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307763:L21SP4_RS08370 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307763:L21SP4_RS07730 ^@ http://purl.uniprot.org/uniprot/A0A0G3EEU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307763:L21SP4_RS02745 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1307763:L21SP4_RS05280 ^@ http://purl.uniprot.org/uniprot/A0A0G3EJM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1307763:L21SP4_RS09310 ^@ http://purl.uniprot.org/uniprot/A0A0G3EK17 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307763:L21SP4_RS00330 ^@ http://purl.uniprot.org/uniprot/A0A0G3EAS0 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/1307763:L21SP4_RS04520 ^@ http://purl.uniprot.org/uniprot/A0A0G3EFK5 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1307763:L21SP4_RS02145 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB40 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1307763:L21SP4_RS07070 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGZ3 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/1307763:L21SP4_RS07090 ^@ http://purl.uniprot.org/uniprot/A0A0G3EE10 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1307763:L21SP4_RS05940 ^@ http://purl.uniprot.org/uniprot/A0A0G3EGC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1307763:L21SP4_RS02095 ^@ http://purl.uniprot.org/uniprot/A0A0G3EB31 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family.