http://togogenome.org/gene/1307761:L21SP2_RS10910 ^@ http://purl.uniprot.org/uniprot/V5WIL0 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/1307761:L21SP2_RS16080 ^@ http://purl.uniprot.org/uniprot/V5WM90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS06385 ^@ http://purl.uniprot.org/uniprot/V5WGS1 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1307761:L21SP2_RS12810 ^@ http://purl.uniprot.org/uniprot/V5WKJ7 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/1307761:L21SP2_RS02150 ^@ http://purl.uniprot.org/uniprot/V5WE79 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307761:L21SP2_RS07145 ^@ http://purl.uniprot.org/uniprot/V5WGE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS06360 ^@ http://purl.uniprot.org/uniprot/V5WGR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1307761:L21SP2_RS02445 ^@ http://purl.uniprot.org/uniprot/V5WDQ8 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/1307761:L21SP2_RS00150 ^@ http://purl.uniprot.org/uniprot/V5WCG6 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS13145 ^@ http://purl.uniprot.org/uniprot/V5WK56 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS05850 ^@ http://purl.uniprot.org/uniprot/V5WHK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS04115 ^@ http://purl.uniprot.org/uniprot/V5WFG6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS15955 ^@ http://purl.uniprot.org/uniprot/V5WLG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS11485 ^@ http://purl.uniprot.org/uniprot/V5WKR6 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/1307761:L21SP2_RS04375 ^@ http://purl.uniprot.org/uniprot/V5WGS0 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/1307761:L21SP2_RS07210 ^@ http://purl.uniprot.org/uniprot/V5WH90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS08760 ^@ http://purl.uniprot.org/uniprot/V5WI54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS11835 ^@ http://purl.uniprot.org/uniprot/V5WJ43 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/1307761:L21SP2_RS00295 ^@ http://purl.uniprot.org/uniprot/V5WCK5 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307761:L21SP2_RS09755 ^@ http://purl.uniprot.org/uniprot/V5WIN2 ^@ Function|||Similarity ^@ Belongs to the CobT family.|||Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). http://togogenome.org/gene/1307761:L21SP2_RS16405 ^@ http://purl.uniprot.org/uniprot/V5WME8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1307761:L21SP2_RS08790 ^@ http://purl.uniprot.org/uniprot/V5WI59 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1307761:L21SP2_RS14105 ^@ http://purl.uniprot.org/uniprot/V5WL22 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1307761:L21SP2_RS05910 ^@ http://purl.uniprot.org/uniprot/V5WFU7 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1307761:L21SP2_RS15545 ^@ http://purl.uniprot.org/uniprot/V5WNP2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307761:L21SP2_RS07345 ^@ http://purl.uniprot.org/uniprot/V5WGJ3 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS03520 ^@ http://purl.uniprot.org/uniprot/V5WEE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS15795 ^@ http://purl.uniprot.org/uniprot/V5WNA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08835 ^@ http://purl.uniprot.org/uniprot/V5WHF4 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS06165 ^@ http://purl.uniprot.org/uniprot/V5WFV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/1307761:L21SP2_RS18710 ^@ http://purl.uniprot.org/uniprot/V5WEF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS15280 ^@ http://purl.uniprot.org/uniprot/V5WL97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS12030 ^@ http://purl.uniprot.org/uniprot/V5WJR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05985 ^@ http://purl.uniprot.org/uniprot/V5WGK1 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS03970 ^@ http://purl.uniprot.org/uniprot/V5WEN2 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/1307761:L21SP2_RS08225 ^@ http://purl.uniprot.org/uniprot/V5WH25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1307761:L21SP2_RS04095 ^@ http://purl.uniprot.org/uniprot/V5WF85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1307761:L21SP2_RS00595 ^@ http://purl.uniprot.org/uniprot/V5WEI5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1307761:L21SP2_RS08275 ^@ http://purl.uniprot.org/uniprot/V5WH66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial flagellin family.|||Component of the core of the flagella.|||Periplasm|||Periplasmic flagellum http://togogenome.org/gene/1307761:L21SP2_RS08720 ^@ http://purl.uniprot.org/uniprot/V5WJ76 ^@ Function ^@ Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/1307761:L21SP2_RS08360 ^@ http://purl.uniprot.org/uniprot/V5WH48 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1307761:L21SP2_RS09750 ^@ http://purl.uniprot.org/uniprot/V5WI02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08915 ^@ http://purl.uniprot.org/uniprot/V5WI14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS10495 ^@ http://purl.uniprot.org/uniprot/V5WIH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS09380 ^@ http://purl.uniprot.org/uniprot/V5WHP1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1307761:L21SP2_RS07225 ^@ http://purl.uniprot.org/uniprot/V5WGG4 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/1307761:L21SP2_RS18870 ^@ http://purl.uniprot.org/uniprot/V5WHZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS02225 ^@ http://purl.uniprot.org/uniprot/V5WE29 ^@ Function|||Similarity ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane. http://togogenome.org/gene/1307761:L21SP2_RS00380 ^@ http://purl.uniprot.org/uniprot/V5WD67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS04020 ^@ http://purl.uniprot.org/uniprot/V5WEP1 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1307761:L21SP2_RS05630 ^@ http://purl.uniprot.org/uniprot/V5WFP8 ^@ Similarity ^@ Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/1307761:L21SP2_RS15390 ^@ http://purl.uniprot.org/uniprot/V5WN50 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/1307761:L21SP2_RS06910 ^@ http://purl.uniprot.org/uniprot/V5WGV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS13160 ^@ http://purl.uniprot.org/uniprot/V5WKS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS07440 ^@ http://purl.uniprot.org/uniprot/V5WGL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00320 ^@ http://purl.uniprot.org/uniprot/V5WCK6 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1307761:L21SP2_RS02935 ^@ http://purl.uniprot.org/uniprot/V5WE45 ^@ Cofactor|||Similarity ^@ Belongs to the UPF0313 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1307761:L21SP2_RS00675 ^@ http://purl.uniprot.org/uniprot/V5WDB2 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/1307761:L21SP2_RS09235 ^@ http://purl.uniprot.org/uniprot/V5WHK7 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/1307761:L21SP2_RS10160 ^@ http://purl.uniprot.org/uniprot/V5WIB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS08695 ^@ http://purl.uniprot.org/uniprot/V5WHA5 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS13830 ^@ http://purl.uniprot.org/uniprot/V5WKD1 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/1307761:L21SP2_RS00465 ^@ http://purl.uniprot.org/uniprot/V5WEG1 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1307761:L21SP2_RS08150 ^@ http://purl.uniprot.org/uniprot/V5WH46 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/1307761:L21SP2_RS11155 ^@ http://purl.uniprot.org/uniprot/V5WIT9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/1307761:L21SP2_RS01830 ^@ http://purl.uniprot.org/uniprot/V5WE07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01990 ^@ http://purl.uniprot.org/uniprot/V5WF91 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/1307761:L21SP2_RS12105 ^@ http://purl.uniprot.org/uniprot/V5WJT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS11900 ^@ http://purl.uniprot.org/uniprot/V5WJ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS14835 ^@ http://purl.uniprot.org/uniprot/V5WKZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS15550 ^@ http://purl.uniprot.org/uniprot/V5WLX9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307761:L21SP2_RS10290 ^@ http://purl.uniprot.org/uniprot/V5WJ29 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1307761:L21SP2_RS16500 ^@ http://purl.uniprot.org/uniprot/V5WNU9 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/1307761:L21SP2_RS15070 ^@ http://purl.uniprot.org/uniprot/V5WLQ9 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307761:L21SP2_RS02755 ^@ http://purl.uniprot.org/uniprot/V5WEH4 ^@ Similarity ^@ Belongs to the UPF0751 family. http://togogenome.org/gene/1307761:L21SP2_RS16330 ^@ http://purl.uniprot.org/uniprot/V5WMC5 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS08515 ^@ http://purl.uniprot.org/uniprot/V5WHA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS02120 ^@ http://purl.uniprot.org/uniprot/V5WDH8 ^@ Cofactor ^@ Binds 2 Mg(2+) ions per monomer. http://togogenome.org/gene/1307761:L21SP2_RS00370 ^@ http://purl.uniprot.org/uniprot/V5WCL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS16455 ^@ http://purl.uniprot.org/uniprot/V5WMF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1307761:L21SP2_RS01550 ^@ http://purl.uniprot.org/uniprot/V5WF12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS13255 ^@ http://purl.uniprot.org/uniprot/V5WKJ1 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/1307761:L21SP2_RS05770 ^@ http://purl.uniprot.org/uniprot/V5WFP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/1307761:L21SP2_RS10235 ^@ http://purl.uniprot.org/uniprot/V5WK32 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/1307761:L21SP2_RS04085 ^@ http://purl.uniprot.org/uniprot/V5WEQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS06835 ^@ http://purl.uniprot.org/uniprot/V5WH16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/1307761:L21SP2_RS11855 ^@ http://purl.uniprot.org/uniprot/V5WKZ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1307761:L21SP2_RS04860 ^@ http://purl.uniprot.org/uniprot/V5WH08 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliG family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS10365 ^@ http://purl.uniprot.org/uniprot/V5WIW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS05815 ^@ http://purl.uniprot.org/uniprot/V5WFT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial flagellin family.|||Component of the core of the flagella.|||Periplasm|||Periplasmic flagellum http://togogenome.org/gene/1307761:L21SP2_RS03615 ^@ http://purl.uniprot.org/uniprot/V5WEF8 ^@ Similarity ^@ Belongs to the hemerythrin family. http://togogenome.org/gene/1307761:L21SP2_RS15995 ^@ http://purl.uniprot.org/uniprot/V5WM92 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/1307761:L21SP2_RS01910 ^@ http://purl.uniprot.org/uniprot/V5WDC5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/1307761:L21SP2_RS00310 ^@ http://purl.uniprot.org/uniprot/V5WEE3 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/1307761:L21SP2_RS12080 ^@ http://purl.uniprot.org/uniprot/V5WJA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NiCoT transporter (TC 2.A.52) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS00960 ^@ http://purl.uniprot.org/uniprot/V5WEP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1307761:L21SP2_RS05260 ^@ http://purl.uniprot.org/uniprot/V5WG66 ^@ Similarity ^@ Belongs to the DapB family. http://togogenome.org/gene/1307761:L21SP2_RS07010 ^@ http://purl.uniprot.org/uniprot/V5WH51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS06390 ^@ http://purl.uniprot.org/uniprot/V5WGK8 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/1307761:L21SP2_RS11825 ^@ http://purl.uniprot.org/uniprot/V5WJN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1307761:L21SP2_RS09250 ^@ http://purl.uniprot.org/uniprot/V5WI65 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/1307761:L21SP2_RS05840 ^@ http://purl.uniprot.org/uniprot/V5WGH3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/1307761:L21SP2_RS10060 ^@ http://purl.uniprot.org/uniprot/V5WI37 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/1307761:L21SP2_RS17595 ^@ http://purl.uniprot.org/uniprot/V5WMJ3 ^@ Function|||Similarity ^@ Belongs to the bacterial histone-like protein family.|||Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. http://togogenome.org/gene/1307761:L21SP2_RS06575 ^@ http://purl.uniprot.org/uniprot/V5WI05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/1307761:L21SP2_RS02370 ^@ http://purl.uniprot.org/uniprot/V5WE59 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1307761:L21SP2_RS03995 ^@ http://purl.uniprot.org/uniprot/V5WEN6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1307761:L21SP2_RS13950 ^@ http://purl.uniprot.org/uniprot/V5WKZ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/1307761:L21SP2_RS05625 ^@ http://purl.uniprot.org/uniprot/V5WFL8 ^@ Function|||Similarity ^@ Belongs to the GTP-binding SRP family.|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/1307761:L21SP2_RS06660 ^@ http://purl.uniprot.org/uniprot/V5WG99 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/1307761:L21SP2_RS13515 ^@ http://purl.uniprot.org/uniprot/V5WKZ6 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1307761:L21SP2_RS08685 ^@ http://purl.uniprot.org/uniprot/V5WHW9 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/1307761:L21SP2_RS06990 ^@ http://purl.uniprot.org/uniprot/V5WH45 ^@ Similarity ^@ Belongs to the phosphate/phosphite/phosphonate binding protein family. http://togogenome.org/gene/1307761:L21SP2_RS10120 ^@ http://purl.uniprot.org/uniprot/V5WIR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PhyH family. EctD subfamily.|||Homodimer.|||Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. http://togogenome.org/gene/1307761:L21SP2_RS06920 ^@ http://purl.uniprot.org/uniprot/V5WGA2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/1307761:L21SP2_RS12680 ^@ http://purl.uniprot.org/uniprot/V5WK89 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS03825 ^@ http://purl.uniprot.org/uniprot/V5WEK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS08065 ^@ http://purl.uniprot.org/uniprot/V5WH32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04870 ^@ http://purl.uniprot.org/uniprot/V5WF75 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS05920 ^@ http://purl.uniprot.org/uniprot/V5WGB9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1307761:L21SP2_RS16585 ^@ http://purl.uniprot.org/uniprot/V5WCS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/1307761:L21SP2_RS07580 ^@ http://purl.uniprot.org/uniprot/V5WH96 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/1307761:L21SP2_RS01070 ^@ http://purl.uniprot.org/uniprot/V5WES2 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. http://togogenome.org/gene/1307761:L21SP2_RS14210 ^@ http://purl.uniprot.org/uniprot/V5WKU6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS01105 ^@ http://purl.uniprot.org/uniprot/V5WDI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/1307761:L21SP2_RS07525 ^@ http://purl.uniprot.org/uniprot/V5WIJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS10185 ^@ http://purl.uniprot.org/uniprot/V5WJ12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/1307761:L21SP2_RS11390 ^@ http://purl.uniprot.org/uniprot/V5WIU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/1307761:L21SP2_RS17525 ^@ http://purl.uniprot.org/uniprot/V5WKD3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS12410 ^@ http://purl.uniprot.org/uniprot/V5WJN3 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/1307761:L21SP2_RS00640 ^@ http://purl.uniprot.org/uniprot/V5WCS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS15960 ^@ http://purl.uniprot.org/uniprot/V5WM63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS02450 ^@ http://purl.uniprot.org/uniprot/V5WEF2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS06155 ^@ http://purl.uniprot.org/uniprot/V5WGG7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/1307761:L21SP2_RS11920 ^@ http://purl.uniprot.org/uniprot/V5WJ67 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1307761:L21SP2_RS16395 ^@ http://purl.uniprot.org/uniprot/V5WNU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05755 ^@ http://purl.uniprot.org/uniprot/V5WGF3 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/1307761:L21SP2_RS05145 ^@ http://purl.uniprot.org/uniprot/V5WFE1 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS14195 ^@ http://purl.uniprot.org/uniprot/V5WL39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS05435 ^@ http://purl.uniprot.org/uniprot/V5WG24 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS00625 ^@ http://purl.uniprot.org/uniprot/V5WDE9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS09020 ^@ http://purl.uniprot.org/uniprot/V5WJD9 ^@ Subcellular Location Annotation ^@ Periplasmic flagellum http://togogenome.org/gene/1307761:L21SP2_RS15490 ^@ http://purl.uniprot.org/uniprot/V5WLZ9 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/1307761:L21SP2_RS01220 ^@ http://purl.uniprot.org/uniprot/V5WEV1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/1307761:L21SP2_RS11415 ^@ http://purl.uniprot.org/uniprot/V5WIV6 ^@ Similarity ^@ Belongs to the RNA polymerase subunit omega family. http://togogenome.org/gene/1307761:L21SP2_RS00910 ^@ http://purl.uniprot.org/uniprot/V5WCW8 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1307761:L21SP2_RS08885 ^@ http://purl.uniprot.org/uniprot/V5WHG3 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/1307761:L21SP2_RS12085 ^@ http://purl.uniprot.org/uniprot/V5WJG1 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/1307761:L21SP2_RS16985 ^@ http://purl.uniprot.org/uniprot/V5WGQ4 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/1307761:L21SP2_RS04160 ^@ http://purl.uniprot.org/uniprot/V5WER5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1307761:L21SP2_RS11610 ^@ http://purl.uniprot.org/uniprot/V5WJK1 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1307761:L21SP2_RS08825 ^@ http://purl.uniprot.org/uniprot/V5WJ97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1307761:L21SP2_RS02965 ^@ http://purl.uniprot.org/uniprot/V5WEV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS13530 ^@ http://purl.uniprot.org/uniprot/V5WK78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/1307761:L21SP2_RS09375 ^@ http://purl.uniprot.org/uniprot/V5WJK3 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/1307761:L21SP2_RS14805 ^@ http://purl.uniprot.org/uniprot/V5WMS3 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1307761:L21SP2_RS13025 ^@ http://purl.uniprot.org/uniprot/V5WKP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS11680 ^@ http://purl.uniprot.org/uniprot/V5WKW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS14085 ^@ http://purl.uniprot.org/uniprot/V5WKJ2 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/1307761:L21SP2_RS12790 ^@ http://purl.uniprot.org/uniprot/V5WJU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/1307761:L21SP2_RS07115 ^@ http://purl.uniprot.org/uniprot/V5WGJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS07245 ^@ http://purl.uniprot.org/uniprot/V5WGH2 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1307761:L21SP2_RS14190 ^@ http://purl.uniprot.org/uniprot/V5WLC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/1307761:L21SP2_RS00935 ^@ http://purl.uniprot.org/uniprot/V5WCV0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/1307761:L21SP2_RS10720 ^@ http://purl.uniprot.org/uniprot/V5WIH8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/1307761:L21SP2_RS01155 ^@ http://purl.uniprot.org/uniprot/V5WDP3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/1307761:L21SP2_RS02825 ^@ http://purl.uniprot.org/uniprot/V5WEI9 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1307761:L21SP2_RS06775 ^@ http://purl.uniprot.org/uniprot/V5WG74 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1307761:L21SP2_RS10010 ^@ http://purl.uniprot.org/uniprot/V5WJY1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/1307761:L21SP2_RS02155 ^@ http://purl.uniprot.org/uniprot/V5WE13 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307761:L21SP2_RS04015 ^@ http://purl.uniprot.org/uniprot/V5WGI9 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/1307761:L21SP2_RS13245 ^@ http://purl.uniprot.org/uniprot/V5WK80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS17065 ^@ http://purl.uniprot.org/uniprot/V5WI94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS03460 ^@ http://purl.uniprot.org/uniprot/V5WG73 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1307761:L21SP2_RS07520 ^@ http://purl.uniprot.org/uniprot/V5WH85 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/1307761:L21SP2_RS03860 ^@ http://purl.uniprot.org/uniprot/V5WGG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00800 ^@ http://purl.uniprot.org/uniprot/V5WDD3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS07505 ^@ http://purl.uniprot.org/uniprot/V5WGM7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS06685 ^@ http://purl.uniprot.org/uniprot/V5WG54 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1307761:L21SP2_RS01615 ^@ http://purl.uniprot.org/uniprot/V5WDX7 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS13985 ^@ http://purl.uniprot.org/uniprot/V5WKG7 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1307761:L21SP2_RS09410 ^@ http://purl.uniprot.org/uniprot/V5WHR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS10305 ^@ http://purl.uniprot.org/uniprot/V5WIA4 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/1307761:L21SP2_RS09480 ^@ http://purl.uniprot.org/uniprot/V5WHT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS06700 ^@ http://purl.uniprot.org/uniprot/V5WGY2 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/1307761:L21SP2_RS12395 ^@ http://purl.uniprot.org/uniprot/V5WK64 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/1307761:L21SP2_RS12060 ^@ http://purl.uniprot.org/uniprot/V5WJF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08830 ^@ http://purl.uniprot.org/uniprot/V5WHC9 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS16355 ^@ http://purl.uniprot.org/uniprot/V5WME1 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/1307761:L21SP2_RS13635 ^@ http://purl.uniprot.org/uniprot/V5WL17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lactate permease family.|||Cell membrane|||Membrane|||Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate. http://togogenome.org/gene/1307761:L21SP2_RS05535 ^@ http://purl.uniprot.org/uniprot/V5WFN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliJ family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS06250 ^@ http://purl.uniprot.org/uniprot/V5WG09 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS05610 ^@ http://purl.uniprot.org/uniprot/V5WGC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliR/MopE/SpaR family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS05570 ^@ http://purl.uniprot.org/uniprot/V5WHF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS11090 ^@ http://purl.uniprot.org/uniprot/V5WIS5 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/1307761:L21SP2_RS01945 ^@ http://purl.uniprot.org/uniprot/V5WDX9 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/1307761:L21SP2_RS11745 ^@ http://purl.uniprot.org/uniprot/V5WJM3 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/1307761:L21SP2_RS02670 ^@ http://purl.uniprot.org/uniprot/V5WDY1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/1307761:L21SP2_RS17390 ^@ http://purl.uniprot.org/uniprot/V5WJ96 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/1307761:L21SP2_RS06300 ^@ http://purl.uniprot.org/uniprot/V5WFY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/1307761:L21SP2_RS17235 ^@ http://purl.uniprot.org/uniprot/V5WHR6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS15865 ^@ http://purl.uniprot.org/uniprot/V5WNA9 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/1307761:L21SP2_RS08965 ^@ http://purl.uniprot.org/uniprot/V5WJD0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/1307761:L21SP2_RS03080 ^@ http://purl.uniprot.org/uniprot/V5WEN7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1307761:L21SP2_RS01345 ^@ http://purl.uniprot.org/uniprot/V5WD26 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/1307761:L21SP2_RS12765 ^@ http://purl.uniprot.org/uniprot/V5WJT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1307761:L21SP2_RS04325 ^@ http://purl.uniprot.org/uniprot/V5WEV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1307761:L21SP2_RS02435 ^@ http://purl.uniprot.org/uniprot/V5WFI7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS08555 ^@ http://purl.uniprot.org/uniprot/V5WHU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1307761:L21SP2_RS12870 ^@ http://purl.uniprot.org/uniprot/V5WJV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS08595 ^@ http://purl.uniprot.org/uniprot/V5WHV0 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307761:L21SP2_RS04090 ^@ http://purl.uniprot.org/uniprot/V5WFG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1307761:L21SP2_RS12620 ^@ http://purl.uniprot.org/uniprot/V5WJX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00225 ^@ http://purl.uniprot.org/uniprot/V5WD49 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1307761:L21SP2_RS11375 ^@ http://purl.uniprot.org/uniprot/V5WJM1 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/1307761:L21SP2_RS16930 ^@ http://purl.uniprot.org/uniprot/V5WFZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS08975 ^@ http://purl.uniprot.org/uniprot/V5WHI3 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1307761:L21SP2_RS08655 ^@ http://purl.uniprot.org/uniprot/V5WI38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1307761:L21SP2_RS01970 ^@ http://purl.uniprot.org/uniprot/V5WF86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS14425 ^@ http://purl.uniprot.org/uniprot/V5WKR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05860 ^@ http://purl.uniprot.org/uniprot/V5WFT9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/1307761:L21SP2_RS10150 ^@ http://purl.uniprot.org/uniprot/V5WK21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS10145 ^@ http://purl.uniprot.org/uniprot/V5WIS8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS05515 ^@ http://purl.uniprot.org/uniprot/V5WFM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliF family.|||Membrane|||The M ring may be actively involved in energy transduction. http://togogenome.org/gene/1307761:L21SP2_RS03280 ^@ http://purl.uniprot.org/uniprot/V5WF15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS11445 ^@ http://purl.uniprot.org/uniprot/V5WJ07 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS05255 ^@ http://purl.uniprot.org/uniprot/V5WFI0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/1307761:L21SP2_RS00200 ^@ http://purl.uniprot.org/uniprot/V5WD44 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/1307761:L21SP2_RS13615 ^@ http://purl.uniprot.org/uniprot/V5WKR8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1307761:L21SP2_RS09505 ^@ http://purl.uniprot.org/uniprot/V5WHU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS06365 ^@ http://purl.uniprot.org/uniprot/V5WGK4 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1307761:L21SP2_RS10325 ^@ http://purl.uniprot.org/uniprot/V5WK45 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/1307761:L21SP2_RS05025 ^@ http://purl.uniprot.org/uniprot/V5WFS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS08450 ^@ http://purl.uniprot.org/uniprot/V5WHR8 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1307761:L21SP2_RS11115 ^@ http://purl.uniprot.org/uniprot/V5WIT0 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/1307761:L21SP2_RS09450 ^@ http://purl.uniprot.org/uniprot/V5WJL8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS09445 ^@ http://purl.uniprot.org/uniprot/V5WIA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS06515 ^@ http://purl.uniprot.org/uniprot/V5WG65 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ClpS family.|||Binds to the N-terminal domain of the chaperone ClpA.|||Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. http://togogenome.org/gene/1307761:L21SP2_RS00025 ^@ http://purl.uniprot.org/uniprot/V5WE63 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1307761:L21SP2_RS14485 ^@ http://purl.uniprot.org/uniprot/V5WLA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS04355 ^@ http://purl.uniprot.org/uniprot/V5WGR6 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/1307761:L21SP2_RS04310 ^@ http://purl.uniprot.org/uniprot/V5WFC8 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS00070 ^@ http://purl.uniprot.org/uniprot/V5WCF5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1307761:L21SP2_RS10430 ^@ http://purl.uniprot.org/uniprot/V5WIX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00395 ^@ http://purl.uniprot.org/uniprot/V5WCL6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS03525 ^@ http://purl.uniprot.org/uniprot/V5WF60 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/1307761:L21SP2_RS00455 ^@ http://purl.uniprot.org/uniprot/V5WCM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS07405 ^@ http://purl.uniprot.org/uniprot/V5WH63 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/1307761:L21SP2_RS04185 ^@ http://purl.uniprot.org/uniprot/V5WES1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1307761:L21SP2_RS15005 ^@ http://purl.uniprot.org/uniprot/V5WLQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS09630 ^@ http://purl.uniprot.org/uniprot/V5WHX1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1307761:L21SP2_RS06350 ^@ http://purl.uniprot.org/uniprot/V5WFZ0 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1307761:L21SP2_RS01540 ^@ http://purl.uniprot.org/uniprot/V5WDW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS05720 ^@ http://purl.uniprot.org/uniprot/V5WFN4 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS06140 ^@ http://purl.uniprot.org/uniprot/V5WGG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08980 ^@ http://purl.uniprot.org/uniprot/V5WI87 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/1307761:L21SP2_RS04150 ^@ http://purl.uniprot.org/uniprot/V5WGM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1307761:L21SP2_RS05690 ^@ http://purl.uniprot.org/uniprot/V5WHH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1307761:L21SP2_RS00940 ^@ http://purl.uniprot.org/uniprot/V5WDK3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS05420 ^@ http://purl.uniprot.org/uniprot/V5WFI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/1307761:L21SP2_RS16665 ^@ http://purl.uniprot.org/uniprot/V5WD72 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1307761:L21SP2_RS07600 ^@ http://purl.uniprot.org/uniprot/V5WHI6 ^@ Similarity ^@ Belongs to the histidinol dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS14695 ^@ http://purl.uniprot.org/uniprot/V5WMQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS08255 ^@ http://purl.uniprot.org/uniprot/V5WHN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1307761:L21SP2_RS14430 ^@ http://purl.uniprot.org/uniprot/V5WKZ3 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/1307761:L21SP2_RS16750 ^@ http://purl.uniprot.org/uniprot/V5WEH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS12855 ^@ http://purl.uniprot.org/uniprot/V5WKK7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS10455 ^@ http://purl.uniprot.org/uniprot/V5WIY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS01580 ^@ http://purl.uniprot.org/uniprot/V5WD64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1307761:L21SP2_RS01315 ^@ http://purl.uniprot.org/uniprot/V5WD47 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/1307761:L21SP2_RS02695 ^@ http://purl.uniprot.org/uniprot/V5WDZ1 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1307761:L21SP2_RS06455 ^@ http://purl.uniprot.org/uniprot/V5WGT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01385 ^@ http://purl.uniprot.org/uniprot/V5WDN6 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/1307761:L21SP2_RS12155 ^@ http://purl.uniprot.org/uniprot/V5WK11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS04215 ^@ http://purl.uniprot.org/uniprot/V5WFI4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS04230 ^@ http://purl.uniprot.org/uniprot/V5WEU4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1307761:L21SP2_RS04885 ^@ http://purl.uniprot.org/uniprot/V5WH14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS04220 ^@ http://purl.uniprot.org/uniprot/V5WFA9 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/1307761:L21SP2_RS04265 ^@ http://purl.uniprot.org/uniprot/V5WFJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1307761:L21SP2_RS08510 ^@ http://purl.uniprot.org/uniprot/V5WH72 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/1307761:L21SP2_RS13275 ^@ http://purl.uniprot.org/uniprot/V5WKU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS12915 ^@ http://purl.uniprot.org/uniprot/V5WKC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01510 ^@ http://purl.uniprot.org/uniprot/V5WDV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS03725 ^@ http://purl.uniprot.org/uniprot/V5WEI2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS05520 ^@ http://purl.uniprot.org/uniprot/V5WGB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliG family.|||Cell inner membrane|||FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01050 ^@ http://purl.uniprot.org/uniprot/V5WCZ6 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS03580 ^@ http://purl.uniprot.org/uniprot/V5WG98 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 30 family. http://togogenome.org/gene/1307761:L21SP2_RS17105 ^@ http://purl.uniprot.org/uniprot/V5WGT6 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/1307761:L21SP2_RS13655 ^@ http://purl.uniprot.org/uniprot/V5WKH0 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/1307761:L21SP2_RS07000 ^@ http://purl.uniprot.org/uniprot/V5WI80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS15850 ^@ http://purl.uniprot.org/uniprot/V5WNR5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1307761:L21SP2_RS09775 ^@ http://purl.uniprot.org/uniprot/V5WI07 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/1307761:L21SP2_RS01075 ^@ http://purl.uniprot.org/uniprot/V5WD02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS10960 ^@ http://purl.uniprot.org/uniprot/V5WIL6 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1307761:L21SP2_RS10705 ^@ http://purl.uniprot.org/uniprot/V5WJA3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS02025 ^@ http://purl.uniprot.org/uniprot/V5WDF6 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1307761:L21SP2_RS15465 ^@ http://purl.uniprot.org/uniprot/V5WLZ5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/1307761:L21SP2_RS06805 ^@ http://purl.uniprot.org/uniprot/V5WG80 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1307761:L21SP2_RS16300 ^@ http://purl.uniprot.org/uniprot/V5WNU1 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/1307761:L21SP2_RS14095 ^@ http://purl.uniprot.org/uniprot/V5WLB5 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/1307761:L21SP2_RS07695 ^@ http://purl.uniprot.org/uniprot/V5WGW9 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/1307761:L21SP2_RS07920 ^@ http://purl.uniprot.org/uniprot/V5WHR0 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/1307761:L21SP2_RS03560 ^@ http://purl.uniprot.org/uniprot/V5WG93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS00050 ^@ http://purl.uniprot.org/uniprot/V5WCE8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1307761:L21SP2_RS13790 ^@ http://purl.uniprot.org/uniprot/V5WL43 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/1307761:L21SP2_RS08210 ^@ http://purl.uniprot.org/uniprot/V5WHV6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1307761:L21SP2_RS01080 ^@ http://purl.uniprot.org/uniprot/V5WCX5 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/1307761:L21SP2_RS12875 ^@ http://purl.uniprot.org/uniprot/V5WK12 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/1307761:L21SP2_RS13510 ^@ http://purl.uniprot.org/uniprot/V5WKD7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1307761:L21SP2_RS01390 ^@ http://purl.uniprot.org/uniprot/V5WEY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS16730 ^@ http://purl.uniprot.org/uniprot/V5WDL8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1307761:L21SP2_RS00840 ^@ http://purl.uniprot.org/uniprot/V5WCT5 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/1307761:L21SP2_RS05500 ^@ http://purl.uniprot.org/uniprot/V5WG36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.|||The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. http://togogenome.org/gene/1307761:L21SP2_RS06370 ^@ http://purl.uniprot.org/uniprot/V5WHW0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1307761:L21SP2_RS05445 ^@ http://purl.uniprot.org/uniprot/V5WFI3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS02580 ^@ http://purl.uniprot.org/uniprot/V5WDU0 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS03675 ^@ http://purl.uniprot.org/uniprot/V5WGC0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1307761:L21SP2_RS11510 ^@ http://purl.uniprot.org/uniprot/V5WKS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS01515 ^@ http://purl.uniprot.org/uniprot/V5WDR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04145 ^@ http://purl.uniprot.org/uniprot/V5WF95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/1307761:L21SP2_RS00055 ^@ http://purl.uniprot.org/uniprot/V5WCE5 ^@ Function ^@ The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. http://togogenome.org/gene/1307761:L21SP2_RS12300 ^@ http://purl.uniprot.org/uniprot/V5WJX2 ^@ Function ^@ Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. http://togogenome.org/gene/1307761:L21SP2_RS14950 ^@ http://purl.uniprot.org/uniprot/V5WLN9 ^@ Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/1307761:L21SP2_RS08700 ^@ http://purl.uniprot.org/uniprot/V5WHD1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1307761:L21SP2_RS10300 ^@ http://purl.uniprot.org/uniprot/V5WK41 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/1307761:L21SP2_RS00630 ^@ http://purl.uniprot.org/uniprot/V5WDA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08480 ^@ http://purl.uniprot.org/uniprot/V5WJ24 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS13285 ^@ http://purl.uniprot.org/uniprot/V5WM40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS03700 ^@ http://purl.uniprot.org/uniprot/V5WEH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS13670 ^@ http://purl.uniprot.org/uniprot/V5WM88 ^@ Similarity ^@ Belongs to the iron-containing alcohol dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS06050 ^@ http://purl.uniprot.org/uniprot/V5WFT7 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/1307761:L21SP2_RS11045 ^@ http://purl.uniprot.org/uniprot/V5WJ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS12920 ^@ http://purl.uniprot.org/uniprot/V5WLX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS15010 ^@ http://purl.uniprot.org/uniprot/V5WNG5 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/1307761:L21SP2_RS15285 ^@ http://purl.uniprot.org/uniprot/V5WLT9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS05440 ^@ http://purl.uniprot.org/uniprot/V5WHC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS09430 ^@ http://purl.uniprot.org/uniprot/V5WHQ2 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS11030 ^@ http://purl.uniprot.org/uniprot/V5WKG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08570 ^@ http://purl.uniprot.org/uniprot/V5WHA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/1307761:L21SP2_RS17735 ^@ http://purl.uniprot.org/uniprot/V5WMB5 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/1307761:L21SP2_RS13555 ^@ http://purl.uniprot.org/uniprot/V5WKE8 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1307761:L21SP2_RS10055 ^@ http://purl.uniprot.org/uniprot/V5WIN4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307761:L21SP2_RS12160 ^@ http://purl.uniprot.org/uniprot/V5WJU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS07860 ^@ http://purl.uniprot.org/uniprot/V5WHH2 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1307761:L21SP2_RS08405 ^@ http://purl.uniprot.org/uniprot/V5WJ10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/1307761:L21SP2_RS08085 ^@ http://purl.uniprot.org/uniprot/V5WHK4 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/1307761:L21SP2_RS04775 ^@ http://purl.uniprot.org/uniprot/V5WFM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/1307761:L21SP2_RS08565 ^@ http://purl.uniprot.org/uniprot/V5WH81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1307761:L21SP2_RS09220 ^@ http://purl.uniprot.org/uniprot/V5WIB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04810 ^@ http://purl.uniprot.org/uniprot/V5WF68 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/1307761:L21SP2_RS05800 ^@ http://purl.uniprot.org/uniprot/V5WGG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FliD family.|||Homopentamer.|||Periplasm|||Periplasmic flagellum|||Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. http://togogenome.org/gene/1307761:L21SP2_RS04645 ^@ http://purl.uniprot.org/uniprot/V5WFR7 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1307761:L21SP2_RS14530 ^@ http://purl.uniprot.org/uniprot/V5WKT4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/1307761:L21SP2_RS05185 ^@ http://purl.uniprot.org/uniprot/V5WH93 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1307761:L21SP2_RS01250 ^@ http://purl.uniprot.org/uniprot/V5WD08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05915 ^@ http://purl.uniprot.org/uniprot/V5WGI7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/1307761:L21SP2_RS04675 ^@ http://purl.uniprot.org/uniprot/V5WGW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS10480 ^@ http://purl.uniprot.org/uniprot/V5WIY6 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1307761:L21SP2_RS02575 ^@ http://purl.uniprot.org/uniprot/V5WDV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/1307761:L21SP2_RS05170 ^@ http://purl.uniprot.org/uniprot/V5WFG2 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/1307761:L21SP2_RS02070 ^@ http://purl.uniprot.org/uniprot/V5WDJ9 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/1307761:L21SP2_RS17170 ^@ http://purl.uniprot.org/uniprot/V5WH77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05845 ^@ http://purl.uniprot.org/uniprot/V5WGA6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1307761:L21SP2_RS14000 ^@ http://purl.uniprot.org/uniprot/V5WL01 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS02200 ^@ http://purl.uniprot.org/uniprot/V5WE91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS07120 ^@ http://purl.uniprot.org/uniprot/V5WH75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/1307761:L21SP2_RS05760 ^@ http://purl.uniprot.org/uniprot/V5WG87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial flagellin family.|||Component of the core of the flagella.|||Periplasmic flagellum http://togogenome.org/gene/1307761:L21SP2_RS12975 ^@ http://purl.uniprot.org/uniprot/V5WK29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliN/MopA/SpaO family.|||Cell membrane|||FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS03540 ^@ http://purl.uniprot.org/uniprot/V5WEE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS12420 ^@ http://purl.uniprot.org/uniprot/V5WK00 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1307761:L21SP2_RS16240 ^@ http://purl.uniprot.org/uniprot/V5WNG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS14995 ^@ http://purl.uniprot.org/uniprot/V5WLP6 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysD subfamily. http://togogenome.org/gene/1307761:L21SP2_RS05490 ^@ http://purl.uniprot.org/uniprot/V5WFM0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/1307761:L21SP2_RS07970 ^@ http://purl.uniprot.org/uniprot/V5WHJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS10435 ^@ http://purl.uniprot.org/uniprot/V5WK65 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1307761:L21SP2_RS06715 ^@ http://purl.uniprot.org/uniprot/V5WGB1 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/1307761:L21SP2_RS04910 ^@ http://purl.uniprot.org/uniprot/V5WH19 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/1307761:L21SP2_RS13640 ^@ http://purl.uniprot.org/uniprot/V5WKS3 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS06215 ^@ http://purl.uniprot.org/uniprot/V5WFW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS06490 ^@ http://purl.uniprot.org/uniprot/V5WG17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS00350 ^@ http://purl.uniprot.org/uniprot/V5WDA0 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/1307761:L21SP2_RS00065 ^@ http://purl.uniprot.org/uniprot/V5WE76 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1307761:L21SP2_RS08625 ^@ http://purl.uniprot.org/uniprot/V5WJ57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1307761:L21SP2_RS00375 ^@ http://purl.uniprot.org/uniprot/V5WDA5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS11955 ^@ http://purl.uniprot.org/uniprot/V5WJW8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/1307761:L21SP2_RS09495 ^@ http://purl.uniprot.org/uniprot/V5WJM6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS07515 ^@ http://purl.uniprot.org/uniprot/V5WHF9 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS00265 ^@ http://purl.uniprot.org/uniprot/V5WCJ9 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/1307761:L21SP2_RS00340 ^@ http://purl.uniprot.org/uniprot/V5WCM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS16495 ^@ http://purl.uniprot.org/uniprot/V5WMG1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/1307761:L21SP2_RS11380 ^@ http://purl.uniprot.org/uniprot/V5WJF2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS00855 ^@ http://purl.uniprot.org/uniprot/V5WEN1 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1307761:L21SP2_RS08890 ^@ http://purl.uniprot.org/uniprot/V5WI72 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/1307761:L21SP2_RS08610 ^@ http://purl.uniprot.org/uniprot/V5WHB6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS09970 ^@ http://purl.uniprot.org/uniprot/V5WJW9 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS03720 ^@ http://purl.uniprot.org/uniprot/V5WEI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS04780 ^@ http://purl.uniprot.org/uniprot/V5WGZ1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated Cas9 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.|||Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.|||Monomer. Binds crRNA and tracrRNA. http://togogenome.org/gene/1307761:L21SP2_RS09760 ^@ http://purl.uniprot.org/uniprot/V5WIH0 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/1307761:L21SP2_RS11480 ^@ http://purl.uniprot.org/uniprot/V5WJH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.|||Belongs to the SrkA/RdoA protein kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS04745 ^@ http://purl.uniprot.org/uniprot/V5WFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS15235 ^@ http://purl.uniprot.org/uniprot/V5WL90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0394 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS13020 ^@ http://purl.uniprot.org/uniprot/V5WK36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS10130 ^@ http://purl.uniprot.org/uniprot/V5WI77 ^@ Function|||Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. http://togogenome.org/gene/1307761:L21SP2_RS11335 ^@ http://purl.uniprot.org/uniprot/V5WKN6 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/1307761:L21SP2_RS15220 ^@ http://purl.uniprot.org/uniprot/V5WN30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS02280 ^@ http://purl.uniprot.org/uniprot/V5WFE6 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1307761:L21SP2_RS15535 ^@ http://purl.uniprot.org/uniprot/V5WN68 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/1307761:L21SP2_RS08020 ^@ http://purl.uniprot.org/uniprot/V5WIV5 ^@ Similarity ^@ Belongs to the YoeB family. http://togogenome.org/gene/1307761:L21SP2_RS11895 ^@ http://purl.uniprot.org/uniprot/V5WJP1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1307761:L21SP2_RS12020 ^@ http://purl.uniprot.org/uniprot/V5WJE5 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS05810 ^@ http://purl.uniprot.org/uniprot/V5WHJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial flagellin family.|||Component of the core of the flagella.|||Periplasm|||Periplasmic flagellum http://togogenome.org/gene/1307761:L21SP2_RS04180 ^@ http://purl.uniprot.org/uniprot/V5WET1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1307761:L21SP2_RS04190 ^@ http://purl.uniprot.org/uniprot/V5WFH8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1307761:L21SP2_RS04890 ^@ http://purl.uniprot.org/uniprot/V5WF84 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/1307761:L21SP2_RS08960 ^@ http://purl.uniprot.org/uniprot/V5WI83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/1307761:L21SP2_RS09710 ^@ http://purl.uniprot.org/uniprot/V5WIM3 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1307761:L21SP2_RS14675 ^@ http://purl.uniprot.org/uniprot/V5WKW4 ^@ Similarity ^@ Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1307761:L21SP2_RS11200 ^@ http://purl.uniprot.org/uniprot/V5WIV1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS15015 ^@ http://purl.uniprot.org/uniprot/V5WL52 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1307761:L21SP2_RS10970 ^@ http://purl.uniprot.org/uniprot/V5WJE6 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1307761:L21SP2_RS04720 ^@ http://purl.uniprot.org/uniprot/V5WFK8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M38 family.|||Binds 2 Zn(2+) ions per subunit.|||Carboxylation allows a single lysine to coordinate two zinc ions.|||Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS09520 ^@ http://purl.uniprot.org/uniprot/V5WJN0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS00205 ^@ http://purl.uniprot.org/uniprot/V5WD12 ^@ Function ^@ The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/1307761:L21SP2_RS06160 ^@ http://purl.uniprot.org/uniprot/V5WHR9 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/1307761:L21SP2_RS16125 ^@ http://purl.uniprot.org/uniprot/V5WLH6 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1307761:L21SP2_RS08260 ^@ http://purl.uniprot.org/uniprot/V5WIY9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS04330 ^@ http://purl.uniprot.org/uniprot/V5WFL1 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/1307761:L21SP2_RS08865 ^@ http://purl.uniprot.org/uniprot/V5WI68 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/1307761:L21SP2_RS01635 ^@ http://purl.uniprot.org/uniprot/V5WDY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08800 ^@ http://purl.uniprot.org/uniprot/V5WJ92 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/1307761:L21SP2_RS01800 ^@ http://purl.uniprot.org/uniprot/V5WDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS04170 ^@ http://purl.uniprot.org/uniprot/V5WF99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS05510 ^@ http://purl.uniprot.org/uniprot/V5WFJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family. http://togogenome.org/gene/1307761:L21SP2_RS10345 ^@ http://purl.uniprot.org/uniprot/V5WIW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS01055 ^@ http://purl.uniprot.org/uniprot/V5WCX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS10700 ^@ http://purl.uniprot.org/uniprot/V5WIL5 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1307761:L21SP2_RS04695 ^@ http://purl.uniprot.org/uniprot/V5WFK2 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1307761:L21SP2_RS02465 ^@ http://purl.uniprot.org/uniprot/V5WDT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS14175 ^@ http://purl.uniprot.org/uniprot/V5WMH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1307761:L21SP2_RS10175 ^@ http://purl.uniprot.org/uniprot/V5WK24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05575 ^@ http://purl.uniprot.org/uniprot/V5WFK9 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/1307761:L21SP2_RS07865 ^@ http://purl.uniprot.org/uniprot/V5WIS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS02290 ^@ http://purl.uniprot.org/uniprot/V5WDL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01140 ^@ http://purl.uniprot.org/uniprot/V5WET6 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/1307761:L21SP2_RS11715 ^@ http://purl.uniprot.org/uniprot/V5WJS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1307761:L21SP2_RS00695 ^@ http://purl.uniprot.org/uniprot/V5WDG2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1307761:L21SP2_RS04165 ^@ http://purl.uniprot.org/uniprot/V5WFH6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS03880 ^@ http://purl.uniprot.org/uniprot/V5WF43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS08920 ^@ http://purl.uniprot.org/uniprot/V5WJB9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS13775 ^@ http://purl.uniprot.org/uniprot/V5WMA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS09215 ^@ http://purl.uniprot.org/uniprot/V5WHM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04630 ^@ http://purl.uniprot.org/uniprot/V5WGV4 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/1307761:L21SP2_RS15965 ^@ http://purl.uniprot.org/uniprot/V5WNC2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1307761:L21SP2_RS12390 ^@ http://purl.uniprot.org/uniprot/V5WJM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS15245 ^@ http://purl.uniprot.org/uniprot/V5WN33 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/1307761:L21SP2_RS12720 ^@ http://purl.uniprot.org/uniprot/V5WJS9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1307761:L21SP2_RS01400 ^@ http://purl.uniprot.org/uniprot/V5WD33 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/1307761:L21SP2_RS16635 ^@ http://purl.uniprot.org/uniprot/V5WD24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS00930 ^@ http://purl.uniprot.org/uniprot/V5WCX2 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS00865 ^@ http://purl.uniprot.org/uniprot/V5WCT9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1307761:L21SP2_RS06795 ^@ http://purl.uniprot.org/uniprot/V5WGT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/1307761:L21SP2_RS05765 ^@ http://purl.uniprot.org/uniprot/V5WHI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.|||Belongs to the FliW family.|||Cytoplasm|||Interacts with translational regulator CsrA and flagellin(s). http://togogenome.org/gene/1307761:L21SP2_RS04280 ^@ http://purl.uniprot.org/uniprot/V5WFK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04175 ^@ http://purl.uniprot.org/uniprot/V5WGM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1307761:L21SP2_RS14775 ^@ http://purl.uniprot.org/uniprot/V5WMR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04640 ^@ http://purl.uniprot.org/uniprot/V5WF25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS03545 ^@ http://purl.uniprot.org/uniprot/V5WEE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS05385 ^@ http://purl.uniprot.org/uniprot/V5WG16 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1307761:L21SP2_RS11530 ^@ http://purl.uniprot.org/uniprot/V5WJI1 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307761:L21SP2_RS15610 ^@ http://purl.uniprot.org/uniprot/V5WLZ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1307761:L21SP2_RS12745 ^@ http://purl.uniprot.org/uniprot/V5WJT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1307761:L21SP2_RS14560 ^@ http://purl.uniprot.org/uniprot/V5WKT9 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS03635 ^@ http://purl.uniprot.org/uniprot/V5WEG4 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1307761:L21SP2_RS13380 ^@ http://purl.uniprot.org/uniprot/V5WKX0 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1307761:L21SP2_RS17005 ^@ http://purl.uniprot.org/uniprot/V5WGU6 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/1307761:L21SP2_RS12785 ^@ http://purl.uniprot.org/uniprot/V5WLV5 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1307761:L21SP2_RS16095 ^@ http://purl.uniprot.org/uniprot/V5WNT3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS05015 ^@ http://purl.uniprot.org/uniprot/V5WFB1 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/1307761:L21SP2_RS04100 ^@ http://purl.uniprot.org/uniprot/V5WGL2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1307761:L21SP2_RS08875 ^@ http://purl.uniprot.org/uniprot/V5WJA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS04730 ^@ http://purl.uniprot.org/uniprot/V5WF51 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/1307761:L21SP2_RS03715 ^@ http://purl.uniprot.org/uniprot/V5WF08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS02000 ^@ http://purl.uniprot.org/uniprot/V5WDE8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/1307761:L21SP2_RS16710 ^@ http://purl.uniprot.org/uniprot/V5WE16 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/1307761:L21SP2_RS16400 ^@ http://purl.uniprot.org/uniprot/V5WLJ5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1307761:L21SP2_RS12775 ^@ http://purl.uniprot.org/uniprot/V5WKJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1307761:L21SP2_RS07875 ^@ http://purl.uniprot.org/uniprot/V5WH01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS00830 ^@ http://purl.uniprot.org/uniprot/V5WEM6 ^@ Similarity ^@ Belongs to the arginine deiminase family. http://togogenome.org/gene/1307761:L21SP2_RS04110 ^@ http://purl.uniprot.org/uniprot/V5WEQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1307761:L21SP2_RS10205 ^@ http://purl.uniprot.org/uniprot/V5WIT7 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/1307761:L21SP2_RS11515 ^@ http://purl.uniprot.org/uniprot/V5WIX5 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS11235 ^@ http://purl.uniprot.org/uniprot/V5WJB7 ^@ Similarity ^@ In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1307761:L21SP2_RS09965 ^@ http://purl.uniprot.org/uniprot/V5WIL7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1307761:L21SP2_RS01300 ^@ http://purl.uniprot.org/uniprot/V5WDS1 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/1307761:L21SP2_RS15240 ^@ http://purl.uniprot.org/uniprot/V5WLT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0394 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS04350 ^@ http://purl.uniprot.org/uniprot/V5WEV9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307761:L21SP2_RS02325 ^@ http://purl.uniprot.org/uniprot/V5WE48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS10465 ^@ http://purl.uniprot.org/uniprot/V5WID5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/1307761:L21SP2_RS00170 ^@ http://purl.uniprot.org/uniprot/V5WCH1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS00010 ^@ http://purl.uniprot.org/uniprot/V5WCD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/1307761:L21SP2_RS13450 ^@ http://purl.uniprot.org/uniprot/V5WKN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01900 ^@ http://purl.uniprot.org/uniprot/V5WDX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS15810 ^@ http://purl.uniprot.org/uniprot/V5WM38 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307761:L21SP2_RS17520 ^@ http://purl.uniprot.org/uniprot/V5WK62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS01585 ^@ http://purl.uniprot.org/uniprot/V5WDX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1307761:L21SP2_RS14955 ^@ http://purl.uniprot.org/uniprot/V5WLP1 ^@ Similarity ^@ Belongs to the hemerythrin family. http://togogenome.org/gene/1307761:L21SP2_RS07495 ^@ http://purl.uniprot.org/uniprot/V5WH78 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/1307761:L21SP2_RS13290 ^@ http://purl.uniprot.org/uniprot/V5WK30 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1307761:L21SP2_RS02345 ^@ http://purl.uniprot.org/uniprot/V5WE54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. http://togogenome.org/gene/1307761:L21SP2_RS11190 ^@ http://purl.uniprot.org/uniprot/V5WKK0 ^@ Function|||Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.|||Catalyzes the biosynthesis of agmatine from arginine. http://togogenome.org/gene/1307761:L21SP2_RS02810 ^@ http://purl.uniprot.org/uniprot/V5WE26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS11355 ^@ http://purl.uniprot.org/uniprot/V5WJE7 ^@ Cofactor|||Similarity ^@ Belongs to the monomeric-type IDH family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/1307761:L21SP2_RS15110 ^@ http://purl.uniprot.org/uniprot/V5WL69 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/1307761:L21SP2_RS01975 ^@ http://purl.uniprot.org/uniprot/V5WDH6 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS01450 ^@ http://purl.uniprot.org/uniprot/V5WD68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/1307761:L21SP2_RS15170 ^@ http://purl.uniprot.org/uniprot/V5WN25 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1307761:L21SP2_RS00245 ^@ http://purl.uniprot.org/uniprot/V5WCJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS08230 ^@ http://purl.uniprot.org/uniprot/V5WH59 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1307761:L21SP2_RS08040 ^@ http://purl.uniprot.org/uniprot/V5WHT1 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS02675 ^@ http://purl.uniprot.org/uniprot/V5WDX8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/1307761:L21SP2_RS00620 ^@ http://purl.uniprot.org/uniprot/V5WCQ2 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1307761:L21SP2_RS00390 ^@ http://purl.uniprot.org/uniprot/V5WCN4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS09625 ^@ http://purl.uniprot.org/uniprot/V5WHU2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1307761:L21SP2_RS00745 ^@ http://purl.uniprot.org/uniprot/V5WDG9 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1307761:L21SP2_RS14500 ^@ http://purl.uniprot.org/uniprot/V5WL05 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1307761:L21SP2_RS13645 ^@ http://purl.uniprot.org/uniprot/V5WM84 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1307761:L21SP2_RS05905 ^@ http://purl.uniprot.org/uniprot/V5WFR5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS05040 ^@ http://purl.uniprot.org/uniprot/V5WFB7 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1307761:L21SP2_RS15000 ^@ http://purl.uniprot.org/uniprot/V5WMZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol monophosphatase superfamily. CysQ family.|||Cell membrane|||Converts adenosine-3',5'-bisphosphate (PAP) to AMP. http://togogenome.org/gene/1307761:L21SP2_RS13385 ^@ http://purl.uniprot.org/uniprot/V5WKM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1307761:L21SP2_RS12780 ^@ http://purl.uniprot.org/uniprot/V5WKA6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1307761:L21SP2_RS08580 ^@ http://purl.uniprot.org/uniprot/V5WHU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/1307761:L21SP2_RS06670 ^@ http://purl.uniprot.org/uniprot/V5WGR5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/1307761:L21SP2_RS14745 ^@ http://purl.uniprot.org/uniprot/V5WMR5 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1307761:L21SP2_RS13735 ^@ http://purl.uniprot.org/uniprot/V5WM98 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS09440 ^@ http://purl.uniprot.org/uniprot/V5WIG6 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/1307761:L21SP2_RS16185 ^@ http://purl.uniprot.org/uniprot/V5WNF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00530 ^@ http://purl.uniprot.org/uniprot/V5WCN6 ^@ Similarity ^@ Belongs to the peptidase A24 family. http://togogenome.org/gene/1307761:L21SP2_RS08705 ^@ http://purl.uniprot.org/uniprot/V5WI47 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/1307761:L21SP2_RS17600 ^@ http://purl.uniprot.org/uniprot/V5WLE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS03710 ^@ http://purl.uniprot.org/uniprot/V5WF96 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/1307761:L21SP2_RS00270 ^@ http://purl.uniprot.org/uniprot/V5WCK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS07905 ^@ http://purl.uniprot.org/uniprot/V5WIT5 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1307761:L21SP2_RS02520 ^@ http://purl.uniprot.org/uniprot/V5WE94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS02175 ^@ http://purl.uniprot.org/uniprot/V5WE86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307761:L21SP2_RS16745 ^@ http://purl.uniprot.org/uniprot/V5WFK3 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/1307761:L21SP2_RS11165 ^@ http://purl.uniprot.org/uniprot/V5WKJ4 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1307761:L21SP2_RS02235 ^@ http://purl.uniprot.org/uniprot/V5WDN5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS13965 ^@ http://purl.uniprot.org/uniprot/V5WKP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ferredoxin thioredoxin reductase beta subunit family.|||Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.|||Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin. http://togogenome.org/gene/1307761:L21SP2_RS07890 ^@ http://purl.uniprot.org/uniprot/V5WIT1 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1307761:L21SP2_RS17125 ^@ http://purl.uniprot.org/uniprot/V5WHQ1 ^@ Function|||Similarity ^@ Belongs to the peptidase S11 family.|||Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. http://togogenome.org/gene/1307761:L21SP2_RS08535 ^@ http://purl.uniprot.org/uniprot/V5WJ35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS13720 ^@ http://purl.uniprot.org/uniprot/V5WKI5 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1307761:L21SP2_RS03040 ^@ http://purl.uniprot.org/uniprot/V5WFZ4 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/1307761:L21SP2_RS08640 ^@ http://purl.uniprot.org/uniprot/V5WI33 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/1307761:L21SP2_RS00775 ^@ http://purl.uniprot.org/uniprot/V5WDC9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1307761:L21SP2_RS16445 ^@ http://purl.uniprot.org/uniprot/V5WMF5 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1307761:L21SP2_RS06735 ^@ http://purl.uniprot.org/uniprot/V5WGZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1307761:L21SP2_RS08390 ^@ http://purl.uniprot.org/uniprot/V5WH80 ^@ Function|||Similarity ^@ Belongs to the MreC family.|||Involved in formation and maintenance of cell shape. http://togogenome.org/gene/1307761:L21SP2_RS15930 ^@ http://purl.uniprot.org/uniprot/V5WLG2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS07100 ^@ http://purl.uniprot.org/uniprot/V5WGZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS12475 ^@ http://purl.uniprot.org/uniprot/V5WJK0 ^@ Similarity ^@ Belongs to the HipA Ser/Thr kinase family. http://togogenome.org/gene/1307761:L21SP2_RS05375 ^@ http://purl.uniprot.org/uniprot/V5WFJ9 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1307761:L21SP2_RS09065 ^@ http://purl.uniprot.org/uniprot/V5WI40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1307761:L21SP2_RS05585 ^@ http://purl.uniprot.org/uniprot/V5WGC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Cell inner membrane|||FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS12715 ^@ http://purl.uniprot.org/uniprot/V5WLT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1307761:L21SP2_RS06785 ^@ http://purl.uniprot.org/uniprot/V5WH04 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/1307761:L21SP2_RS09415 ^@ http://purl.uniprot.org/uniprot/V5WIG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS12725 ^@ http://purl.uniprot.org/uniprot/V5WJY7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1307761:L21SP2_RS04455 ^@ http://purl.uniprot.org/uniprot/V5WGT0 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS04155 ^@ http://purl.uniprot.org/uniprot/V5WES5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1307761:L21SP2_RS01575 ^@ http://purl.uniprot.org/uniprot/V5WD93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane|||Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).|||The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. http://togogenome.org/gene/1307761:L21SP2_RS02890 ^@ http://purl.uniprot.org/uniprot/V5WE23 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. http://togogenome.org/gene/1307761:L21SP2_RS05495 ^@ http://purl.uniprot.org/uniprot/V5WGA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS02265 ^@ http://purl.uniprot.org/uniprot/V5WDL4 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/1307761:L21SP2_RS08985 ^@ http://purl.uniprot.org/uniprot/V5WI26 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/1307761:L21SP2_RS06485 ^@ http://purl.uniprot.org/uniprot/V5WGM8 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS02425 ^@ http://purl.uniprot.org/uniprot/V5WEE7 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1307761:L21SP2_RS08220 ^@ http://purl.uniprot.org/uniprot/V5WIY3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/1307761:L21SP2_RS07285 ^@ http://purl.uniprot.org/uniprot/V5WH35 ^@ Similarity ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily. http://togogenome.org/gene/1307761:L21SP2_RS14140 ^@ http://purl.uniprot.org/uniprot/V5WKT0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1307761:L21SP2_RS03770 ^@ http://purl.uniprot.org/uniprot/V5WEJ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS17725 ^@ http://purl.uniprot.org/uniprot/V5WM99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS10440 ^@ http://purl.uniprot.org/uniprot/V5WIC9 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/1307761:L21SP2_RS12880 ^@ http://purl.uniprot.org/uniprot/V5WKL2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/1307761:L21SP2_RS04305 ^@ http://purl.uniprot.org/uniprot/V5WFK5 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1307761:L21SP2_RS08925 ^@ http://purl.uniprot.org/uniprot/V5WHF1 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/1307761:L21SP2_RS13150 ^@ http://purl.uniprot.org/uniprot/V5WKR7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS14615 ^@ http://purl.uniprot.org/uniprot/V5WLC0 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS13440 ^@ http://purl.uniprot.org/uniprot/V5WKC2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS15455 ^@ http://purl.uniprot.org/uniprot/V5WLW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/1307761:L21SP2_RS11525 ^@ http://purl.uniprot.org/uniprot/V5WJP2 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/1307761:L21SP2_RS06335 ^@ http://purl.uniprot.org/uniprot/V5WGR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS13880 ^@ http://purl.uniprot.org/uniprot/V5WKX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS16105 ^@ http://purl.uniprot.org/uniprot/V5WM93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS12990 ^@ http://purl.uniprot.org/uniprot/V5WLY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS06710 ^@ http://purl.uniprot.org/uniprot/V5WG58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS12755 ^@ http://purl.uniprot.org/uniprot/V5WKA0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1307761:L21SP2_RS09275 ^@ http://purl.uniprot.org/uniprot/V5WJI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.|||Cytoplasm|||Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity. http://togogenome.org/gene/1307761:L21SP2_RS13270 ^@ http://purl.uniprot.org/uniprot/V5WK86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS04135 ^@ http://purl.uniprot.org/uniprot/V5WER3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1307761:L21SP2_RS01815 ^@ http://purl.uniprot.org/uniprot/V5WDW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS16050 ^@ http://purl.uniprot.org/uniprot/V5WNT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS13500 ^@ http://purl.uniprot.org/uniprot/V5WKP3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/1307761:L21SP2_RS16505 ^@ http://purl.uniprot.org/uniprot/V5WLJ9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1307761:L21SP2_RS11580 ^@ http://purl.uniprot.org/uniprot/V5WIZ0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/1307761:L21SP2_RS16480 ^@ http://purl.uniprot.org/uniprot/V5WLJ8 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/1307761:L21SP2_RS10125 ^@ http://purl.uniprot.org/uniprot/V5WK18 ^@ Function|||Similarity ^@ Belongs to the ectoine synthase family.|||Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant. http://togogenome.org/gene/1307761:L21SP2_RS15520 ^@ http://purl.uniprot.org/uniprot/V5WNP0 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS08365 ^@ http://purl.uniprot.org/uniprot/V5WH76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/1307761:L21SP2_RS15020 ^@ http://purl.uniprot.org/uniprot/V5WLQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/1307761:L21SP2_RS04345 ^@ http://purl.uniprot.org/uniprot/V5WEX2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307761:L21SP2_RS15860 ^@ http://purl.uniprot.org/uniprot/V5WM46 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS04140 ^@ http://purl.uniprot.org/uniprot/V5WFH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1307761:L21SP2_RS03630 ^@ http://purl.uniprot.org/uniprot/V5WGA8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS08635 ^@ http://purl.uniprot.org/uniprot/V5WHB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/1307761:L21SP2_RS09155 ^@ http://purl.uniprot.org/uniprot/V5WI52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/1307761:L21SP2_RS16065 ^@ http://purl.uniprot.org/uniprot/V5WND3 ^@ Similarity ^@ Belongs to the photoactive yellow protein family. http://togogenome.org/gene/1307761:L21SP2_RS10340 ^@ http://purl.uniprot.org/uniprot/V5WJ37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS17445 ^@ http://purl.uniprot.org/uniprot/V5WJL6 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1307761:L21SP2_RS09510 ^@ http://purl.uniprot.org/uniprot/V5WII3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS11260 ^@ http://purl.uniprot.org/uniprot/V5WKL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05465 ^@ http://purl.uniprot.org/uniprot/V5WFI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1307761:L21SP2_RS16285 ^@ http://purl.uniprot.org/uniprot/V5WMB8 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1307761:L21SP2_RS05505 ^@ http://purl.uniprot.org/uniprot/V5WHD9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/1307761:L21SP2_RS03440 ^@ http://purl.uniprot.org/uniprot/V5WED2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/1307761:L21SP2_RS00965 ^@ http://purl.uniprot.org/uniprot/V5WCX7 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1307761:L21SP2_RS04340 ^@ http://purl.uniprot.org/uniprot/V5WGR1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1307761:L21SP2_RS08615 ^@ http://purl.uniprot.org/uniprot/V5WI28 ^@ Caution|||Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1307761:L21SP2_RS11925 ^@ http://purl.uniprot.org/uniprot/V5WJC2 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/1307761:L21SP2_RS17030 ^@ http://purl.uniprot.org/uniprot/V5WI49 ^@ Similarity ^@ Belongs to the PTH family. http://togogenome.org/gene/1307761:L21SP2_RS05265 ^@ http://purl.uniprot.org/uniprot/V5WFZ9 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS07130 ^@ http://purl.uniprot.org/uniprot/V5WIB2 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/1307761:L21SP2_RS08395 ^@ http://purl.uniprot.org/uniprot/V5WHY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS13225 ^@ http://purl.uniprot.org/uniprot/V5WK75 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS13105 ^@ http://purl.uniprot.org/uniprot/V5WKF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS10065 ^@ http://purl.uniprot.org/uniprot/V5WI74 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/1307761:L21SP2_RS08180 ^@ http://purl.uniprot.org/uniprot/V5WH49 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/1307761:L21SP2_RS10375 ^@ http://purl.uniprot.org/uniprot/V5WIB7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1307761:L21SP2_RS13565 ^@ http://purl.uniprot.org/uniprot/V5WKQ8 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/1307761:L21SP2_RS09420 ^@ http://purl.uniprot.org/uniprot/V5WI96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0073 (Hly-III) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS02010 ^@ http://purl.uniprot.org/uniprot/V5WDY9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1307761:L21SP2_RS07715 ^@ http://purl.uniprot.org/uniprot/V5WGX5 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS15250 ^@ http://purl.uniprot.org/uniprot/V5WLV3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/1307761:L21SP2_RS08440 ^@ http://purl.uniprot.org/uniprot/V5WH88 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1307761:L21SP2_RS13520 ^@ http://purl.uniprot.org/uniprot/V5WKP8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/1307761:L21SP2_RS00195 ^@ http://purl.uniprot.org/uniprot/V5WCH6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1307761:L21SP2_RS16170 ^@ http://purl.uniprot.org/uniprot/V5WLH9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/1307761:L21SP2_RS07720 ^@ http://purl.uniprot.org/uniprot/V5WHM6 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/1307761:L21SP2_RS13030 ^@ http://purl.uniprot.org/uniprot/V5WKE2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase. http://togogenome.org/gene/1307761:L21SP2_RS13995 ^@ http://purl.uniprot.org/uniprot/V5WL82 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1307761:L21SP2_RS07550 ^@ http://purl.uniprot.org/uniprot/V5WH91 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/1307761:L21SP2_RS01240 ^@ http://purl.uniprot.org/uniprot/V5WEV5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS08385 ^@ http://purl.uniprot.org/uniprot/V5WH53 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Belongs to the heat shock protein 70 family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS05880 ^@ http://purl.uniprot.org/uniprot/V5WFR2 ^@ Subcellular Location Annotation ^@ Periplasmic flagellum http://togogenome.org/gene/1307761:L21SP2_RS13330 ^@ http://purl.uniprot.org/uniprot/V5WKW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1307761:L21SP2_RS09280 ^@ http://purl.uniprot.org/uniprot/V5WHL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS09400 ^@ http://purl.uniprot.org/uniprot/V5WJK7 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/1307761:L21SP2_RS08820 ^@ http://purl.uniprot.org/uniprot/V5WHZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS15815 ^@ http://purl.uniprot.org/uniprot/V5WNA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS12595 ^@ http://purl.uniprot.org/uniprot/V5WJR2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS01935 ^@ http://purl.uniprot.org/uniprot/V5WDD2 ^@ Caution|||Function|||Similarity ^@ Belongs to the Dus family. DusA subfamily.|||Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS11830 ^@ http://purl.uniprot.org/uniprot/V5WKY6 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1307761:L21SP2_RS05605 ^@ http://purl.uniprot.org/uniprot/V5WFP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/1307761:L21SP2_RS05560 ^@ http://purl.uniprot.org/uniprot/V5WGB8 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/1307761:L21SP2_RS09850 ^@ http://purl.uniprot.org/uniprot/V5WIQ1 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1307761:L21SP2_RS06500 ^@ http://purl.uniprot.org/uniprot/V5WGN4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/1307761:L21SP2_RS10850 ^@ http://purl.uniprot.org/uniprot/V5WKC8 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1307761:L21SP2_RS15915 ^@ http://purl.uniprot.org/uniprot/V5WNB6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/1307761:L21SP2_RS02560 ^@ http://purl.uniprot.org/uniprot/V5WDV4 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/1307761:L21SP2_RS10490 ^@ http://purl.uniprot.org/uniprot/V5WIE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS14010 ^@ http://purl.uniprot.org/uniprot/V5WKP9 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/1307761:L21SP2_RS11860 ^@ http://purl.uniprot.org/uniprot/V5WJ49 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/1307761:L21SP2_RS02440 ^@ http://purl.uniprot.org/uniprot/V5WDS8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/1307761:L21SP2_RS08470 ^@ http://purl.uniprot.org/uniprot/V5WHZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS15830 ^@ http://purl.uniprot.org/uniprot/V5WLF3 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1307761:L21SP2_RS08575 ^@ http://purl.uniprot.org/uniprot/V5WI18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1307761:L21SP2_RS15855 ^@ http://purl.uniprot.org/uniprot/V5WLF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1307761:L21SP2_RS02230 ^@ http://purl.uniprot.org/uniprot/V5WFD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1307761:L21SP2_RS05200 ^@ http://purl.uniprot.org/uniprot/V5WG53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS12655 ^@ http://purl.uniprot.org/uniprot/V5WK85 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00585 ^@ http://purl.uniprot.org/uniprot/V5WDE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS07205 ^@ http://purl.uniprot.org/uniprot/V5WGL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS03225 ^@ http://purl.uniprot.org/uniprot/V5WE92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS11230 ^@ http://purl.uniprot.org/uniprot/V5WJJ2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1307761:L21SP2_RS10390 ^@ http://purl.uniprot.org/uniprot/V5WK55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/1307761:L21SP2_RS15685 ^@ http://purl.uniprot.org/uniprot/V5WNQ2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/1307761:L21SP2_RS15330 ^@ http://purl.uniprot.org/uniprot/V5WLA2 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1307761:L21SP2_RS04830 ^@ http://purl.uniprot.org/uniprot/V5WH03 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1307761:L21SP2_RS00005 ^@ http://purl.uniprot.org/uniprot/V5WCD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/1307761:L21SP2_RS11820 ^@ http://purl.uniprot.org/uniprot/V5WJT9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1307761:L21SP2_RS01085 ^@ http://purl.uniprot.org/uniprot/V5WDI1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS12760 ^@ http://purl.uniprot.org/uniprot/V5WLV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1307761:L21SP2_RS13535 ^@ http://purl.uniprot.org/uniprot/V5WKE3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1307761:L21SP2_RS06480 ^@ http://purl.uniprot.org/uniprot/V5WGT8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS08175 ^@ http://purl.uniprot.org/uniprot/V5WH15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1307761:L21SP2_RS02530 ^@ http://purl.uniprot.org/uniprot/V5WDU9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/1307761:L21SP2_RS00905 ^@ http://purl.uniprot.org/uniprot/V5WEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS14725 ^@ http://purl.uniprot.org/uniprot/V5WKX4 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS06220 ^@ http://purl.uniprot.org/uniprot/V5WG06 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1307761:L21SP2_RS04120 ^@ http://purl.uniprot.org/uniprot/V5WF90 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1307761:L21SP2_RS12750 ^@ http://purl.uniprot.org/uniprot/V5WJZ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/1307761:L21SP2_RS08265 ^@ http://purl.uniprot.org/uniprot/V5WH34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/1307761:L21SP2_RS15210 ^@ http://purl.uniprot.org/uniprot/V5WL88 ^@ Similarity ^@ Belongs to the hemerythrin family. http://togogenome.org/gene/1307761:L21SP2_RS00955 ^@ http://purl.uniprot.org/uniprot/V5WDF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1307761:L21SP2_RS03980 ^@ http://purl.uniprot.org/uniprot/V5WFE0 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1307761:L21SP2_RS06555 ^@ http://purl.uniprot.org/uniprot/V5WI00 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS14710 ^@ http://purl.uniprot.org/uniprot/V5WLI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS01870 ^@ http://purl.uniprot.org/uniprot/V5WE10 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1307761:L21SP2_RS04705 ^@ http://purl.uniprot.org/uniprot/V5WF44 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily. http://togogenome.org/gene/1307761:L21SP2_RS02570 ^@ http://purl.uniprot.org/uniprot/V5WFM2 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1307761:L21SP2_RS08600 ^@ http://purl.uniprot.org/uniprot/V5WJ52 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/1307761:L21SP2_RS15750 ^@ http://purl.uniprot.org/uniprot/V5WN95 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/1307761:L21SP2_RS16085 ^@ http://purl.uniprot.org/uniprot/V5WND6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS00060 ^@ http://purl.uniprot.org/uniprot/V5WD14 ^@ Function ^@ The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. http://togogenome.org/gene/1307761:L21SP2_RS17480 ^@ http://purl.uniprot.org/uniprot/V5WJX1 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS03220 ^@ http://purl.uniprot.org/uniprot/V5WE98 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/1307761:L21SP2_RS12325 ^@ http://purl.uniprot.org/uniprot/V5WJX9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS10370 ^@ http://purl.uniprot.org/uniprot/V5WK53 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS11470 ^@ http://purl.uniprot.org/uniprot/V5WJ14 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1307761:L21SP2_RS08310 ^@ http://purl.uniprot.org/uniprot/V5WHP4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1307761:L21SP2_RS08645 ^@ http://purl.uniprot.org/uniprot/V5WHV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS17370 ^@ http://purl.uniprot.org/uniprot/V5WKL0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1307761:L21SP2_RS00345 ^@ http://purl.uniprot.org/uniprot/V5WCL0 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1307761:L21SP2_RS06070 ^@ http://purl.uniprot.org/uniprot/V5WGE7 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1307761:L21SP2_RS09975 ^@ http://purl.uniprot.org/uniprot/V5WI16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS12220 ^@ http://purl.uniprot.org/uniprot/V5WL70 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1307761:L21SP2_RS06650 ^@ http://purl.uniprot.org/uniprot/V5WI20 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/1307761:L21SP2_RS09795 ^@ http://purl.uniprot.org/uniprot/V5WHX7 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS12830 ^@ http://purl.uniprot.org/uniprot/V5WK05 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/1307761:L21SP2_RS05020 ^@ http://purl.uniprot.org/uniprot/V5WFZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS08895 ^@ http://purl.uniprot.org/uniprot/V5WI08 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/1307761:L21SP2_RS06395 ^@ http://purl.uniprot.org/uniprot/V5WHW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS17560 ^@ http://purl.uniprot.org/uniprot/V5WMC7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HMG-CoA reductase family.|||Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS07435 ^@ http://purl.uniprot.org/uniprot/V5WII0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS04105 ^@ http://purl.uniprot.org/uniprot/V5WER4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1307761:L21SP2_RS07380 ^@ http://purl.uniprot.org/uniprot/V5WHC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS06210 ^@ http://purl.uniprot.org/uniprot/V5WHS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/1307761:L21SP2_RS00240 ^@ http://purl.uniprot.org/uniprot/V5WCI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS04935 ^@ http://purl.uniprot.org/uniprot/V5WH24 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1307761:L21SP2_RS00135 ^@ http://purl.uniprot.org/uniprot/V5WCZ5 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1307761:L21SP2_RS05620 ^@ http://purl.uniprot.org/uniprot/V5WHG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Cell membrane|||Membrane|||Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/1307761:L21SP2_RS07610 ^@ http://purl.uniprot.org/uniprot/V5WIM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TER reductase family.|||Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS10425 ^@ http://purl.uniprot.org/uniprot/V5WJ53 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/1307761:L21SP2_RS12845 ^@ http://purl.uniprot.org/uniprot/V5WLW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS02245 ^@ http://purl.uniprot.org/uniprot/V5WEA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1307761:L21SP2_RS10020 ^@ http://purl.uniprot.org/uniprot/V5WI64 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/1307761:L21SP2_RS07295 ^@ http://purl.uniprot.org/uniprot/V5WGI2 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS06745 ^@ http://purl.uniprot.org/uniprot/V5WI41 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1307761:L21SP2_RS03475 ^@ http://purl.uniprot.org/uniprot/V5WF50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS15970 ^@ http://purl.uniprot.org/uniprot/V5WM89 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1307761:L21SP2_RS10555 ^@ http://purl.uniprot.org/uniprot/V5WJ77 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/1307761:L21SP2_RS01440 ^@ http://purl.uniprot.org/uniprot/V5WDP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/1307761:L21SP2_RS09980 ^@ http://purl.uniprot.org/uniprot/V5WI55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1307761:L21SP2_RS00730 ^@ http://purl.uniprot.org/uniprot/V5WDC0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1307761:L21SP2_RS03620 ^@ http://purl.uniprot.org/uniprot/V5WF78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS11005 ^@ http://purl.uniprot.org/uniprot/V5WKF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1307761:L21SP2_RS02165 ^@ http://purl.uniprot.org/uniprot/V5WDM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1307761:L21SP2_RS13405 ^@ http://purl.uniprot.org/uniprot/V5WKX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS12770 ^@ http://purl.uniprot.org/uniprot/V5WJZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1307761:L21SP2_RS07765 ^@ http://purl.uniprot.org/uniprot/V5WHN6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/1307761:L21SP2_RS15555 ^@ http://purl.uniprot.org/uniprot/V5WN71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS01215 ^@ http://purl.uniprot.org/uniprot/V5WDK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/1307761:L21SP2_RS03740 ^@ http://purl.uniprot.org/uniprot/V5WGD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1307761:L21SP2_RS13730 ^@ http://purl.uniprot.org/uniprot/V5WKU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS14205 ^@ http://purl.uniprot.org/uniprot/V5WKL7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1307761:L21SP2_RS03655 ^@ http://purl.uniprot.org/uniprot/V5WGB5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1307761:L21SP2_RS02410 ^@ http://purl.uniprot.org/uniprot/V5WE70 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1307761:L21SP2_RS10980 ^@ http://purl.uniprot.org/uniprot/V5WKF5 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/1307761:L21SP2_RS14080 ^@ http://purl.uniprot.org/uniprot/V5WMG5 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/1307761:L21SP2_RS10105 ^@ http://purl.uniprot.org/uniprot/V5WI57 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1307761:L21SP2_RS07850 ^@ http://purl.uniprot.org/uniprot/V5WHP7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/1307761:L21SP2_RS10525 ^@ http://purl.uniprot.org/uniprot/V5WJ71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS00750 ^@ http://purl.uniprot.org/uniprot/V5WDC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS05320 ^@ http://purl.uniprot.org/uniprot/V5WG08 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1307761:L21SP2_RS04385 ^@ http://purl.uniprot.org/uniprot/V5WEX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0394 family.|||Membrane http://togogenome.org/gene/1307761:L21SP2_RS02365 ^@ http://purl.uniprot.org/uniprot/V5WED1 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1307761:L21SP2_RS06120 ^@ http://purl.uniprot.org/uniprot/V5WHQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS17755 ^@ http://purl.uniprot.org/uniprot/V5WLJ1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1307761:L21SP2_RS09260 ^@ http://purl.uniprot.org/uniprot/V5WHL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1307761:L21SP2_RS09315 ^@ http://purl.uniprot.org/uniprot/V5WID9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family.