http://togogenome.org/gene/1227739:HSW_RS07305 ^@ http://purl.uniprot.org/uniprot/W8EUC6 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/1227739:HSW_RS04195 ^@ http://purl.uniprot.org/uniprot/W8F2Y0 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/1227739:HSW_RS14645 ^@ http://purl.uniprot.org/uniprot/W8EYZ3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS14570 ^@ http://purl.uniprot.org/uniprot/W8F092 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS20960 ^@ http://purl.uniprot.org/uniprot/W8F2M2 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/1227739:HSW_RS03910 ^@ http://purl.uniprot.org/uniprot/W8EUB3 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/1227739:HSW_RS11570 ^@ http://purl.uniprot.org/uniprot/W8EYM4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1227739:HSW_RS15005 ^@ http://purl.uniprot.org/uniprot/W8F356 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1227739:HSW_RS18765 ^@ http://purl.uniprot.org/uniprot/W8F2N0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1227739:HSW_RS17060 ^@ http://purl.uniprot.org/uniprot/W8F0C1 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/1227739:HSW_RS13485 ^@ http://purl.uniprot.org/uniprot/W8F660 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.|||Cytoplasm|||Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). http://togogenome.org/gene/1227739:HSW_RS07195 ^@ http://purl.uniprot.org/uniprot/W8F2E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS01855 ^@ http://purl.uniprot.org/uniprot/W8F1H3 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/1227739:HSW_RS03930 ^@ http://purl.uniprot.org/uniprot/W8EWF2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1227739:HSW_RS19425 ^@ http://purl.uniprot.org/uniprot/W8F1N8 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/1227739:HSW_RS13030 ^@ http://purl.uniprot.org/uniprot/W8EY37 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1227739:HSW_RS02170 ^@ http://purl.uniprot.org/uniprot/W8ERG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/1227739:HSW_RS16475 ^@ http://purl.uniprot.org/uniprot/W8F7W2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/1227739:HSW_RS09235 ^@ http://purl.uniprot.org/uniprot/W8F611 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/1227739:HSW_RS03185 ^@ http://purl.uniprot.org/uniprot/W8F079 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS09875 ^@ http://purl.uniprot.org/uniprot/W8F6F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS19860 ^@ http://purl.uniprot.org/uniprot/W8F202 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/1227739:HSW_RS00570 ^@ http://purl.uniprot.org/uniprot/W8EQL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS01715 ^@ http://purl.uniprot.org/uniprot/W8ER80 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1227739:HSW_RS04020 ^@ http://purl.uniprot.org/uniprot/W8EWG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03590 ^@ http://purl.uniprot.org/uniprot/W8F0D9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1227739:HSW_RS16605 ^@ http://purl.uniprot.org/uniprot/W8F1G1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1227739:HSW_RS15865 ^@ http://purl.uniprot.org/uniprot/W8F7J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/1227739:HSW_RS11185 ^@ http://purl.uniprot.org/uniprot/W8F7B1 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1227739:HSW_RS18960 ^@ http://purl.uniprot.org/uniprot/W8F2R3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS16720 ^@ http://purl.uniprot.org/uniprot/W8F055 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS16585 ^@ http://purl.uniprot.org/uniprot/W8F034 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1227739:HSW_RS20810 ^@ http://purl.uniprot.org/uniprot/W8F6F6 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/1227739:HSW_RS01885 ^@ http://purl.uniprot.org/uniprot/W8EZ97 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/1227739:HSW_RS17420 ^@ http://purl.uniprot.org/uniprot/W8F1Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS06295 ^@ http://purl.uniprot.org/uniprot/W8EVN6 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1227739:HSW_RS14910 ^@ http://purl.uniprot.org/uniprot/W8F0H3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/1227739:HSW_RS22105 ^@ http://purl.uniprot.org/uniprot/W8F398 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS19185 ^@ http://purl.uniprot.org/uniprot/W8FC54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1227739:HSW_RS04170 ^@ http://purl.uniprot.org/uniprot/W8F0M9 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carbamylation allows a single lysine to coordinate two nickel ions.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/1227739:HSW_RS21090 ^@ http://purl.uniprot.org/uniprot/W8FD91 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS12835 ^@ http://purl.uniprot.org/uniprot/W8F5V3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/1227739:HSW_RS12905 ^@ http://purl.uniprot.org/uniprot/W8EZC4 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/1227739:HSW_RS03255 ^@ http://purl.uniprot.org/uniprot/W8F2F7 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/1227739:HSW_RS13480 ^@ http://purl.uniprot.org/uniprot/W8F8Q8 ^@ Similarity|||Subunit ^@ Belongs to the RNase H family.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS17220 ^@ http://purl.uniprot.org/uniprot/W8F0F9 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/1227739:HSW_RS16265 ^@ http://purl.uniprot.org/uniprot/W8EZY1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1227739:HSW_RS07170 ^@ http://purl.uniprot.org/uniprot/W8F2E2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/1227739:HSW_RS14350 ^@ http://purl.uniprot.org/uniprot/W8F6M3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the arabinose isomerase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of L-arabinose to L-ribulose. http://togogenome.org/gene/1227739:HSW_RS14155 ^@ http://purl.uniprot.org/uniprot/W8F6I3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS14830 ^@ http://purl.uniprot.org/uniprot/W8EZ36 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS05100 ^@ http://purl.uniprot.org/uniprot/W8F186 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/1227739:HSW_RS18705 ^@ http://purl.uniprot.org/uniprot/W8F954 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1227739:HSW_RS08050 ^@ http://purl.uniprot.org/uniprot/W8F320 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS16040 ^@ http://purl.uniprot.org/uniprot/W8F3N6 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/1227739:HSW_RS09335 ^@ http://purl.uniprot.org/uniprot/W8EZN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/1227739:HSW_RS11890 ^@ http://purl.uniprot.org/uniprot/W8F166 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/1227739:HSW_RS11225 ^@ http://purl.uniprot.org/uniprot/W8EX20 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/1227739:HSW_RS21925 ^@ http://purl.uniprot.org/uniprot/W8FB24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS00575 ^@ http://purl.uniprot.org/uniprot/W8F0R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS02795 ^@ http://purl.uniprot.org/uniprot/W8EVW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/1227739:HSW_RS23085 ^@ http://purl.uniprot.org/uniprot/W8F8T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS12910 ^@ http://purl.uniprot.org/uniprot/W8EY14 ^@ PTM|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/1227739:HSW_RS11710 ^@ http://purl.uniprot.org/uniprot/W8EXA4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS10160 ^@ http://purl.uniprot.org/uniprot/W8EVY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS10350 ^@ http://purl.uniprot.org/uniprot/W8EY11 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1227739:HSW_RS04160 ^@ http://purl.uniprot.org/uniprot/W8ESM1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease beta subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/1227739:HSW_RS10595 ^@ http://purl.uniprot.org/uniprot/W8EY57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LpxC family.|||Belongs to the thioester dehydratase family. FabZ subfamily.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/1227739:HSW_RS14300 ^@ http://purl.uniprot.org/uniprot/W8F6L3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 51 family. http://togogenome.org/gene/1227739:HSW_RS00895 ^@ http://purl.uniprot.org/uniprot/W8EYS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21110 ^@ http://purl.uniprot.org/uniprot/W8F2Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1227739:HSW_RS18860 ^@ http://purl.uniprot.org/uniprot/W8F596 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1227739:HSW_RS22080 ^@ http://purl.uniprot.org/uniprot/W8F391 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS10695 ^@ http://purl.uniprot.org/uniprot/W8F4J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS02285 ^@ http://purl.uniprot.org/uniprot/W8F1Q7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1227739:HSW_RS05605 ^@ http://purl.uniprot.org/uniprot/W8EXI9 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/1227739:HSW_RS13885 ^@ http://purl.uniprot.org/uniprot/W8EZW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS20715 ^@ http://purl.uniprot.org/uniprot/W8F6D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03850 ^@ http://purl.uniprot.org/uniprot/W8EWE1 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/1227739:HSW_RS08990 ^@ http://purl.uniprot.org/uniprot/W8EX45 ^@ Similarity ^@ Belongs to the Lgt family. http://togogenome.org/gene/1227739:HSW_RS12480 ^@ http://purl.uniprot.org/uniprot/W8EZ43 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/1227739:HSW_RS10550 ^@ http://purl.uniprot.org/uniprot/W8EWN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS16405 ^@ http://purl.uniprot.org/uniprot/W8F3V5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/1227739:HSW_RS22940 ^@ http://purl.uniprot.org/uniprot/W8F6Q6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS18760 ^@ http://purl.uniprot.org/uniprot/W8F578 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS18695 ^@ http://purl.uniprot.org/uniprot/W8F1A5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1227739:HSW_RS12960 ^@ http://purl.uniprot.org/uniprot/W8F8G1 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/1227739:HSW_RS16105 ^@ http://purl.uniprot.org/uniprot/W8F169 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS20950 ^@ http://purl.uniprot.org/uniprot/W8FD62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS17980 ^@ http://purl.uniprot.org/uniprot/W8F284 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/1227739:HSW_RS10635 ^@ http://purl.uniprot.org/uniprot/W8F0H4 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/1227739:HSW_RS09400 ^@ http://purl.uniprot.org/uniprot/W8F3R7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.|||Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Binds 1 siroheme per subunit.|||Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. http://togogenome.org/gene/1227739:HSW_RS14785 ^@ http://purl.uniprot.org/uniprot/W8F9I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the etk/wzc family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS18915 ^@ http://purl.uniprot.org/uniprot/W8F1E6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS07345 ^@ http://purl.uniprot.org/uniprot/W8EW69 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/1227739:HSW_RS22520 ^@ http://purl.uniprot.org/uniprot/W8ET09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS09280 ^@ http://purl.uniprot.org/uniprot/W8F3P1 ^@ Cofactor|||Similarity ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/1227739:HSW_RS09365 ^@ http://purl.uniprot.org/uniprot/W8EXB9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS12750 ^@ http://purl.uniprot.org/uniprot/W8EXY3 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1227739:HSW_RS05050 ^@ http://purl.uniprot.org/uniprot/W8F176 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1227739:HSW_RS16395 ^@ http://purl.uniprot.org/uniprot/W8FAG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS21575 ^@ http://purl.uniprot.org/uniprot/W8F2Y9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/1227739:HSW_RS16005 ^@ http://purl.uniprot.org/uniprot/W8EZT8 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/1227739:HSW_RS15615 ^@ http://purl.uniprot.org/uniprot/W8EZL7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1227739:HSW_RS02930 ^@ http://purl.uniprot.org/uniprot/W8F255 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1227739:HSW_RS21535 ^@ http://purl.uniprot.org/uniprot/W8F2Y1 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/1227739:HSW_RS18850 ^@ http://purl.uniprot.org/uniprot/W8FBY9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1227739:HSW_RS11365 ^@ http://purl.uniprot.org/uniprot/W8F0U6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS16145 ^@ http://purl.uniprot.org/uniprot/W8F7P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS23850 ^@ http://purl.uniprot.org/uniprot/W8FBW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1227739:HSW_RS05670 ^@ http://purl.uniprot.org/uniprot/W8F3Y6 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1227739:HSW_RS01455 ^@ http://purl.uniprot.org/uniprot/W8EV34 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/1227739:HSW_RS18090 ^@ http://purl.uniprot.org/uniprot/W8FBJ4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1227739:HSW_RS06210 ^@ http://purl.uniprot.org/uniprot/W8EVM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS02280 ^@ http://purl.uniprot.org/uniprot/W8ERJ3 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1227739:HSW_RS00470 ^@ http://purl.uniprot.org/uniprot/W8EYG4 ^@ Similarity ^@ Belongs to the NtaA/SnaA/DszA monooxygenase family. http://togogenome.org/gene/1227739:HSW_RS10135 ^@ http://purl.uniprot.org/uniprot/W8EVY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||Cytoplasm|||Specifically methylates the adenine in position 1618 of 23S rRNA. http://togogenome.org/gene/1227739:HSW_RS08645 ^@ http://purl.uniprot.org/uniprot/W8F5Q1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS02840 ^@ http://purl.uniprot.org/uniprot/W8F228 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/1227739:HSW_RS16290 ^@ http://purl.uniprot.org/uniprot/W8EZY5 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit B family. http://togogenome.org/gene/1227739:HSW_RS11470 ^@ http://purl.uniprot.org/uniprot/W8F7G2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS15145 ^@ http://purl.uniprot.org/uniprot/W8F778 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/1227739:HSW_RS13020 ^@ http://purl.uniprot.org/uniprot/W8F1X4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1227739:HSW_RS08880 ^@ http://purl.uniprot.org/uniprot/W8EZD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS13595 ^@ http://purl.uniprot.org/uniprot/W8EZQ7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1227739:HSW_RS21950 ^@ http://purl.uniprot.org/uniprot/W8FB29 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/1227739:HSW_RS16410 ^@ http://purl.uniprot.org/uniprot/W8F1C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS15260 ^@ http://purl.uniprot.org/uniprot/W8F395 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1227739:HSW_RS21195 ^@ http://purl.uniprot.org/uniprot/W8F6N9 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/1227739:HSW_RS01900 ^@ http://purl.uniprot.org/uniprot/W8F1I3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS07670 ^@ http://purl.uniprot.org/uniprot/W8EWC8 ^@ Function ^@ May be involved in the biogenesis of curli organelles. http://togogenome.org/gene/1227739:HSW_RS14055 ^@ http://purl.uniprot.org/uniprot/W8F2G5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1227739:HSW_RS11045 ^@ http://purl.uniprot.org/uniprot/W8F4Q1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus|||Lysosome|||Secreted http://togogenome.org/gene/1227739:HSW_RS18085 ^@ http://purl.uniprot.org/uniprot/W8F0Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/1227739:HSW_RS18715 ^@ http://purl.uniprot.org/uniprot/W8F2L9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS01820 ^@ http://purl.uniprot.org/uniprot/W8ET08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1227739:HSW_RS15940 ^@ http://purl.uniprot.org/uniprot/W8F133 ^@ Function|||Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/1227739:HSW_RS05330 ^@ http://purl.uniprot.org/uniprot/W8EX93 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/1227739:HSW_RS14410 ^@ http://purl.uniprot.org/uniprot/W8F059 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/1227739:HSW_RS11940 ^@ http://purl.uniprot.org/uniprot/W8F178 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.|||In the N-terminal section; belongs to the histidinol-phosphatase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS09505 ^@ http://purl.uniprot.org/uniprot/W8EVL1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1227739:HSW_RS10600 ^@ http://purl.uniprot.org/uniprot/W8EWP2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/1227739:HSW_RS08780 ^@ http://purl.uniprot.org/uniprot/W8F3D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1227739:HSW_RS22630 ^@ http://purl.uniprot.org/uniprot/W8EYH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS04690 ^@ http://purl.uniprot.org/uniprot/W8EUP3 ^@ Similarity ^@ Belongs to the CvfB family. http://togogenome.org/gene/1227739:HSW_RS02730 ^@ http://purl.uniprot.org/uniprot/W8ERS4 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/1227739:HSW_RS15170 ^@ http://purl.uniprot.org/uniprot/W8EZD8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1227739:HSW_RS21960 ^@ http://purl.uniprot.org/uniprot/W8F4E5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/1227739:HSW_RS18750 ^@ http://purl.uniprot.org/uniprot/W8FBW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS01830 ^@ http://purl.uniprot.org/uniprot/W8F1G9 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1227739:HSW_RS02065 ^@ http://purl.uniprot.org/uniprot/W8ET45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS21780 ^@ http://purl.uniprot.org/uniprot/W8FAZ4 ^@ Function|||Similarity ^@ Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/1227739:HSW_RS12370 ^@ http://purl.uniprot.org/uniprot/W8F5I3 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1227739:HSW_RS07220 ^@ http://purl.uniprot.org/uniprot/W8F2F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS03395 ^@ http://purl.uniprot.org/uniprot/W8EU21 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS06410 ^@ http://purl.uniprot.org/uniprot/W8EXW0 ^@ PTM|||Similarity|||Subunit ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaved by autocatalysis into a large and a small subunit.|||This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide. http://togogenome.org/gene/1227739:HSW_RS10430 ^@ http://purl.uniprot.org/uniprot/W8EWK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS12655 ^@ http://purl.uniprot.org/uniprot/W8F8A8 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS21300 ^@ http://purl.uniprot.org/uniprot/W8FAP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS18415 ^@ http://purl.uniprot.org/uniprot/W8F2G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS08885 ^@ http://purl.uniprot.org/uniprot/W8EX31 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS22165 ^@ http://purl.uniprot.org/uniprot/W8FB72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS01875 ^@ http://purl.uniprot.org/uniprot/W8ERB3 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/1227739:HSW_RS09950 ^@ http://purl.uniprot.org/uniprot/W8F6H1 ^@ Similarity|||Subunit ^@ Belongs to the FPG family.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS20820 ^@ http://purl.uniprot.org/uniprot/W8F2J3 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/1227739:HSW_RS16010 ^@ http://purl.uniprot.org/uniprot/W8FA86 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/1227739:HSW_RS10325 ^@ http://purl.uniprot.org/uniprot/W8EY07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.|||Cell inner membrane|||Intake of glucose and galactose.|||Membrane http://togogenome.org/gene/1227739:HSW_RS21380 ^@ http://purl.uniprot.org/uniprot/W8FAQ5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS16035 ^@ http://purl.uniprot.org/uniprot/W8F7M7 ^@ Function ^@ Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1227739:HSW_RS19820 ^@ http://purl.uniprot.org/uniprot/W8F9T0 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/1227739:HSW_RS15930 ^@ http://purl.uniprot.org/uniprot/W8F7K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS19345 ^@ http://purl.uniprot.org/uniprot/W8F2Y3 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/1227739:HSW_RS02045 ^@ http://purl.uniprot.org/uniprot/W8ERE7 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS18875 ^@ http://purl.uniprot.org/uniprot/W8FBZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/1227739:HSW_RS13060 ^@ http://purl.uniprot.org/uniprot/W8F5Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS03335 ^@ http://purl.uniprot.org/uniprot/W8F099 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/1227739:HSW_RS04990 ^@ http://purl.uniprot.org/uniprot/W8ET26 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1227739:HSW_RS09445 ^@ http://purl.uniprot.org/uniprot/W8F657 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20540 ^@ http://purl.uniprot.org/uniprot/W8F3M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS18665 ^@ http://purl.uniprot.org/uniprot/W8F2K9 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/1227739:HSW_RS18800 ^@ http://purl.uniprot.org/uniprot/W8FBX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS11955 ^@ http://purl.uniprot.org/uniprot/W8F7R6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1227739:HSW_RS02755 ^@ http://purl.uniprot.org/uniprot/W8ERS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20415 ^@ http://purl.uniprot.org/uniprot/W8FCW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS16525 ^@ http://purl.uniprot.org/uniprot/W8F7X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS01825 ^@ http://purl.uniprot.org/uniprot/W8ERA4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1227739:HSW_RS18775 ^@ http://purl.uniprot.org/uniprot/W8FBX5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1227739:HSW_RS16685 ^@ http://purl.uniprot.org/uniprot/W8F1H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS19415 ^@ http://purl.uniprot.org/uniprot/W8F5K8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1227739:HSW_RS05775 ^@ http://purl.uniprot.org/uniprot/W8F1N9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/1227739:HSW_RS14450 ^@ http://purl.uniprot.org/uniprot/W8F2Q0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS19180 ^@ http://purl.uniprot.org/uniprot/W8F2V5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/1227739:HSW_RS13540 ^@ http://purl.uniprot.org/uniprot/W8F264 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS20670 ^@ http://purl.uniprot.org/uniprot/W8F6D0 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/1227739:HSW_RS21175 ^@ http://purl.uniprot.org/uniprot/W8F3Y8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/1227739:HSW_RS04605 ^@ http://purl.uniprot.org/uniprot/W8F364 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/1227739:HSW_RS18620 ^@ http://purl.uniprot.org/uniprot/W8F189 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/1227739:HSW_RS20555 ^@ http://purl.uniprot.org/uniprot/W8FA96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS10560 ^@ http://purl.uniprot.org/uniprot/W8F4H8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS13535 ^@ http://purl.uniprot.org/uniprot/W8F666 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/1227739:HSW_RS10445 ^@ http://purl.uniprot.org/uniprot/W8F0E1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1227739:HSW_RS22120 ^@ http://purl.uniprot.org/uniprot/W8F779 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS11935 ^@ http://purl.uniprot.org/uniprot/W8F584 ^@ Similarity ^@ Belongs to the tRNA(His) guanylyltransferase family. http://togogenome.org/gene/1227739:HSW_RS04840 ^@ http://purl.uniprot.org/uniprot/W8ET00 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/1227739:HSW_RS14435 ^@ http://purl.uniprot.org/uniprot/W8EYU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS13950 ^@ http://purl.uniprot.org/uniprot/W8F6E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/1227739:HSW_RS10215 ^@ http://purl.uniprot.org/uniprot/W8F6P4 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1227739:HSW_RS02900 ^@ http://purl.uniprot.org/uniprot/W8ETN4 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1227739:HSW_RS23515 ^@ http://purl.uniprot.org/uniprot/W8F7M3 ^@ Function ^@ Might have a role analogous to that of eukaryotic histone proteins. http://togogenome.org/gene/1227739:HSW_RS19390 ^@ http://purl.uniprot.org/uniprot/W8F5K2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/1227739:HSW_RS05725 ^@ http://purl.uniprot.org/uniprot/W8F1N4 ^@ Similarity ^@ Belongs to the barstar family. http://togogenome.org/gene/1227739:HSW_RS10440 ^@ http://purl.uniprot.org/uniprot/W8F4G1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/1227739:HSW_RS07015 ^@ http://purl.uniprot.org/uniprot/W8F2A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0719 family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS05045 ^@ http://purl.uniprot.org/uniprot/W8F3F3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/1227739:HSW_RS13915 ^@ http://purl.uniprot.org/uniprot/W8EYJ8 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/1227739:HSW_RS02845 ^@ http://purl.uniprot.org/uniprot/W8EZY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/1227739:HSW_RS13865 ^@ http://purl.uniprot.org/uniprot/W8EZW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03855 ^@ http://purl.uniprot.org/uniprot/W8EUA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/1227739:HSW_RS11660 ^@ http://purl.uniprot.org/uniprot/W8F113 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/1227739:HSW_RS09800 ^@ http://purl.uniprot.org/uniprot/W8EXK8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 63 family. http://togogenome.org/gene/1227739:HSW_RS08955 ^@ http://purl.uniprot.org/uniprot/W8F3G9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. http://togogenome.org/gene/1227739:HSW_RS05935 ^@ http://purl.uniprot.org/uniprot/W8ETP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS19495 ^@ http://purl.uniprot.org/uniprot/W8F1Q2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1227739:HSW_RS19245 ^@ http://purl.uniprot.org/uniprot/W8F5H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Cell membrane|||H(+)-stimulated, divalent metal cation uptake system. http://togogenome.org/gene/1227739:HSW_RS20665 ^@ http://purl.uniprot.org/uniprot/W8FAB9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1227739:HSW_RS09390 ^@ http://purl.uniprot.org/uniprot/W8EVI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS04945 ^@ http://purl.uniprot.org/uniprot/W8F150 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/1227739:HSW_RS05635 ^@ http://purl.uniprot.org/uniprot/W8EVC0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1227739:HSW_RS18700 ^@ http://purl.uniprot.org/uniprot/W8FBV8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1227739:HSW_RS14150 ^@ http://purl.uniprot.org/uniprot/W8F931 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS22060 ^@ http://purl.uniprot.org/uniprot/W8FDV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS18675 ^@ http://purl.uniprot.org/uniprot/W8FBV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1227739:HSW_RS05110 ^@ http://purl.uniprot.org/uniprot/W8EUX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/1227739:HSW_RS01420 ^@ http://purl.uniprot.org/uniprot/W8F187 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1227739:HSW_RS08190 ^@ http://purl.uniprot.org/uniprot/W8EUV2 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/1227739:HSW_RS17965 ^@ http://purl.uniprot.org/uniprot/W8FBH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS13900 ^@ http://purl.uniprot.org/uniprot/W8F6D4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS22095 ^@ http://purl.uniprot.org/uniprot/W8F773 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/1227739:HSW_RS13100 ^@ http://purl.uniprot.org/uniprot/W8EY50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS04800 ^@ http://purl.uniprot.org/uniprot/W8F120 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily. http://togogenome.org/gene/1227739:HSW_RS05495 ^@ http://purl.uniprot.org/uniprot/W8F1K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1227739:HSW_RS05825 ^@ http://purl.uniprot.org/uniprot/W8EXL9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS10190 ^@ http://purl.uniprot.org/uniprot/W8F6N7 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/1227739:HSW_RS16045 ^@ http://purl.uniprot.org/uniprot/W8F154 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1227739:HSW_RS13280 ^@ http://purl.uniprot.org/uniprot/W8F213 ^@ Function|||Similarity ^@ Belongs to the peptidase S51 family.|||Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides. http://togogenome.org/gene/1227739:HSW_RS05705 ^@ http://purl.uniprot.org/uniprot/W8EXK4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS12060 ^@ http://purl.uniprot.org/uniprot/W8F5A9 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/1227739:HSW_RS06310 ^@ http://purl.uniprot.org/uniprot/W8EXU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS21410 ^@ http://purl.uniprot.org/uniprot/W8F6S3 ^@ Similarity ^@ Belongs to the DinB family. http://togogenome.org/gene/1227739:HSW_RS14345 ^@ http://purl.uniprot.org/uniprot/W8F972 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS18560 ^@ http://purl.uniprot.org/uniprot/W8FBS8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS14695 ^@ http://purl.uniprot.org/uniprot/W8EZ05 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS06570 ^@ http://purl.uniprot.org/uniprot/W8EXZ0 ^@ Cofactor|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/1227739:HSW_RS18000 ^@ http://purl.uniprot.org/uniprot/W8F4U3 ^@ Function|||Similarity ^@ Belongs to the HMBS family.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. http://togogenome.org/gene/1227739:HSW_RS04415 ^@ http://purl.uniprot.org/uniprot/W8EWP1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/1227739:HSW_RS14470 ^@ http://purl.uniprot.org/uniprot/W8F2Q5 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS04780 ^@ http://purl.uniprot.org/uniprot/W8EUR0 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1227739:HSW_RS09130 ^@ http://purl.uniprot.org/uniprot/W8EVD1 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/1227739:HSW_RS19055 ^@ http://purl.uniprot.org/uniprot/W8F9B6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1227739:HSW_RS18625 ^@ http://purl.uniprot.org/uniprot/W8FBU3 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/1227739:HSW_RS03625 ^@ http://purl.uniprot.org/uniprot/W8EWA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/1227739:HSW_RS16240 ^@ http://purl.uniprot.org/uniprot/W8EZX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/1227739:HSW_RS08530 ^@ http://purl.uniprot.org/uniprot/W8EZ65 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1227739:HSW_RS06960 ^@ http://purl.uniprot.org/uniprot/W8EU68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS17025 ^@ http://purl.uniprot.org/uniprot/W8F486 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1227739:HSW_RS16925 ^@ http://purl.uniprot.org/uniprot/W8F465 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/1227739:HSW_RS09550 ^@ http://purl.uniprot.org/uniprot/W8EXF5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS11960 ^@ http://purl.uniprot.org/uniprot/W8F588 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/1227739:HSW_RS11390 ^@ http://purl.uniprot.org/uniprot/W8F0V1 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1227739:HSW_RS16025 ^@ http://purl.uniprot.org/uniprot/W8F3N0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1227739:HSW_RS15765 ^@ http://purl.uniprot.org/uniprot/W8FA47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/1227739:HSW_RS09765 ^@ http://purl.uniprot.org/uniprot/W8F3Z5 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS11100 ^@ http://purl.uniprot.org/uniprot/W8F0P4 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/1227739:HSW_RS14065 ^@ http://purl.uniprot.org/uniprot/W8EYM3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. http://togogenome.org/gene/1227739:HSW_RS10085 ^@ http://purl.uniprot.org/uniprot/W8EVX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS15760 ^@ http://purl.uniprot.org/uniprot/W8EZP5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/1227739:HSW_RS14235 ^@ http://purl.uniprot.org/uniprot/W8F2K2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Homotetramer. http://togogenome.org/gene/1227739:HSW_RS02955 ^@ http://purl.uniprot.org/uniprot/W8F260 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1227739:HSW_RS04910 ^@ http://purl.uniprot.org/uniprot/W8EUT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS20660 ^@ http://purl.uniprot.org/uniprot/W8F2F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1227739:HSW_RS18735 ^@ http://purl.uniprot.org/uniprot/W8F574 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/1227739:HSW_RS02295 ^@ http://purl.uniprot.org/uniprot/W8EVL2 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1227739:HSW_RS06025 ^@ http://purl.uniprot.org/uniprot/W8F451 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT. http://togogenome.org/gene/1227739:HSW_RS18985 ^@ http://purl.uniprot.org/uniprot/W8F2R6 ^@ Similarity ^@ Belongs to the DNA glycosylase MPG family. http://togogenome.org/gene/1227739:HSW_RS18685 ^@ http://purl.uniprot.org/uniprot/W8F565 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1227739:HSW_RS12780 ^@ http://purl.uniprot.org/uniprot/W8EXY9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS16270 ^@ http://purl.uniprot.org/uniprot/W8FAE1 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/1227739:HSW_RS18520 ^@ http://purl.uniprot.org/uniprot/W8F2I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS14510 ^@ http://purl.uniprot.org/uniprot/W8F6R1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/1227739:HSW_RS04955 ^@ http://purl.uniprot.org/uniprot/W8EUU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/1227739:HSW_RS19080 ^@ http://purl.uniprot.org/uniprot/W8F9C1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the WrbA family.|||Binds 1 FMN per monomer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS02890 ^@ http://purl.uniprot.org/uniprot/W8EZZ2 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/1227739:HSW_RS07595 ^@ http://purl.uniprot.org/uniprot/W8EWB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS06050 ^@ http://purl.uniprot.org/uniprot/W8F456 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1227739:HSW_RS15420 ^@ http://purl.uniprot.org/uniprot/W8F7C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1227739:HSW_RS06875 ^@ http://purl.uniprot.org/uniprot/W8EY49 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1227739:HSW_RS07800 ^@ http://purl.uniprot.org/uniprot/W8EYR1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1227739:HSW_RS13390 ^@ http://purl.uniprot.org/uniprot/W8F234 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1227739:HSW_RS06390 ^@ http://purl.uniprot.org/uniprot/W8EVQ3 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1227739:HSW_RS07235 ^@ http://purl.uniprot.org/uniprot/W8EUB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/1227739:HSW_RS05385 ^@ http://purl.uniprot.org/uniprot/W8ETB0 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1227739:HSW_RS09360 ^@ http://purl.uniprot.org/uniprot/W8EZN7 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1227739:HSW_RS18645 ^@ http://purl.uniprot.org/uniprot/W8F195 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1227739:HSW_RS21640 ^@ http://purl.uniprot.org/uniprot/W8F6X5 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/1227739:HSW_RS21420 ^@ http://purl.uniprot.org/uniprot/W8F2W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS07745 ^@ http://purl.uniprot.org/uniprot/W8F556 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/1227739:HSW_RS16640 ^@ http://purl.uniprot.org/uniprot/W8FAM3 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/1227739:HSW_RS21730 ^@ http://purl.uniprot.org/uniprot/W8FAY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1227739:HSW_RS11380 ^@ http://purl.uniprot.org/uniprot/W8F7E5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/1227739:HSW_RS16460 ^@ http://purl.uniprot.org/uniprot/W8F1D4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/1227739:HSW_RS12500 ^@ http://purl.uniprot.org/uniprot/W8F1I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS16520 ^@ http://purl.uniprot.org/uniprot/W8FAJ8 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS21890 ^@ http://purl.uniprot.org/uniprot/W8F349 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/1227739:HSW_RS05325 ^@ http://purl.uniprot.org/uniprot/W8F1D7 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS03470 ^@ http://purl.uniprot.org/uniprot/W8F0B9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1227739:HSW_RS04055 ^@ http://purl.uniprot.org/uniprot/W8ESK3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1227739:HSW_RS07990 ^@ http://purl.uniprot.org/uniprot/W8EWL6 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/1227739:HSW_RS18820 ^@ http://purl.uniprot.org/uniprot/W8F1D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS16880 ^@ http://purl.uniprot.org/uniprot/W8F455 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/1227739:HSW_RS03235 ^@ http://purl.uniprot.org/uniprot/W8F086 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1227739:HSW_RS11325 ^@ http://purl.uniprot.org/uniprot/W8EX36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS05080 ^@ http://purl.uniprot.org/uniprot/W8EX37 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS03085 ^@ http://purl.uniprot.org/uniprot/W8F2C3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS05770 ^@ http://purl.uniprot.org/uniprot/W8F404 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus|||Lysosome|||Secreted http://togogenome.org/gene/1227739:HSW_RS08765 ^@ http://purl.uniprot.org/uniprot/W8EX09 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/1227739:HSW_RS00950 ^@ http://purl.uniprot.org/uniprot/W8EQS5 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS16575 ^@ http://purl.uniprot.org/uniprot/W8F3Z1 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/1227739:HSW_RS21675 ^@ http://purl.uniprot.org/uniprot/W8F308 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS06565 ^@ http://purl.uniprot.org/uniprot/W8F215 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03550 ^@ http://purl.uniprot.org/uniprot/W8EU49 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/1227739:HSW_RS13235 ^@ http://purl.uniprot.org/uniprot/W8F8K5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1227739:HSW_RS02010 ^@ http://purl.uniprot.org/uniprot/W8EVE9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS10000 ^@ http://purl.uniprot.org/uniprot/W8EXQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS09095 ^@ http://purl.uniprot.org/uniprot/W8F3K0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS12435 ^@ http://purl.uniprot.org/uniprot/W8EXP7 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS15175 ^@ http://purl.uniprot.org/uniprot/W8F9U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS13935 ^@ http://purl.uniprot.org/uniprot/W8EZX7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1227739:HSW_RS14880 ^@ http://purl.uniprot.org/uniprot/W8EZ46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS18795 ^@ http://purl.uniprot.org/uniprot/W8F1C7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1227739:HSW_RS07320 ^@ http://purl.uniprot.org/uniprot/W8EYE5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1227739:HSW_RS04240 ^@ http://purl.uniprot.org/uniprot/W8ESN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/1227739:HSW_RS05505 ^@ http://purl.uniprot.org/uniprot/W8EV99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1227739:HSW_RS14485 ^@ http://purl.uniprot.org/uniprot/W8F9A4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS21590 ^@ http://purl.uniprot.org/uniprot/W8F6W4 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/1227739:HSW_RS19385 ^@ http://purl.uniprot.org/uniprot/W8F9J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1227739:HSW_RS11740 ^@ http://purl.uniprot.org/uniprot/W8EXB1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS07200 ^@ http://purl.uniprot.org/uniprot/W8EYB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS02165 ^@ http://purl.uniprot.org/uniprot/W8ET63 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/1227739:HSW_RS06945 ^@ http://purl.uniprot.org/uniprot/W8F295 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/1227739:HSW_RS07555 ^@ http://purl.uniprot.org/uniprot/W8EWA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS06730 ^@ http://purl.uniprot.org/uniprot/W8EU27 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the CobB/CobQ family.|||Involved in acetate metabolism.|||The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site. http://togogenome.org/gene/1227739:HSW_RS16920 ^@ http://purl.uniprot.org/uniprot/W8F863 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/1227739:HSW_RS22655 ^@ http://purl.uniprot.org/uniprot/W8EUQ8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/1227739:HSW_RS15755 ^@ http://purl.uniprot.org/uniprot/W8F3H3 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1227739:HSW_RS09070 ^@ http://purl.uniprot.org/uniprot/W8EZH4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS22665 ^@ http://purl.uniprot.org/uniprot/W8EUT4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1227739:HSW_RS02035 ^@ http://purl.uniprot.org/uniprot/W8EVF5 ^@ Function|||Similarity ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. http://togogenome.org/gene/1227739:HSW_RS14700 ^@ http://purl.uniprot.org/uniprot/W8F6V1 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1227739:HSW_RS15405 ^@ http://purl.uniprot.org/uniprot/W8F3B5 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1227739:HSW_RS11765 ^@ http://purl.uniprot.org/uniprot/W8EXB6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/1227739:HSW_RS11925 ^@ http://purl.uniprot.org/uniprot/W8EXE9 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS08240 ^@ http://purl.uniprot.org/uniprot/W8EWR3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1227739:HSW_RS02290 ^@ http://purl.uniprot.org/uniprot/W8EZJ9 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1227739:HSW_RS04340 ^@ http://purl.uniprot.org/uniprot/W8EWM5 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1227739:HSW_RS16400 ^@ http://purl.uniprot.org/uniprot/W8F7U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS18240 ^@ http://purl.uniprot.org/uniprot/W8F2D1 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/1227739:HSW_RS03145 ^@ http://purl.uniprot.org/uniprot/W8EW41 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/1227739:HSW_RS05030 ^@ http://purl.uniprot.org/uniprot/W8EX28 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS01545 ^@ http://purl.uniprot.org/uniprot/W8ESV9 ^@ Similarity|||Subunit ^@ Homotetramer.|||In the C-terminal section; belongs to the homoserine dehydrogenase family.|||In the N-terminal section; belongs to the aspartokinase family. http://togogenome.org/gene/1227739:HSW_RS06550 ^@ http://purl.uniprot.org/uniprot/W8EVT3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/1227739:HSW_RS20635 ^@ http://purl.uniprot.org/uniprot/W8F2F4 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1227739:HSW_RS03385 ^@ http://purl.uniprot.org/uniprot/W8F0A4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/1227739:HSW_RS09860 ^@ http://purl.uniprot.org/uniprot/W8F415 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS13625 ^@ http://purl.uniprot.org/uniprot/W8F8T5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03210 ^@ http://purl.uniprot.org/uniprot/W8F082 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/1227739:HSW_RS05565 ^@ http://purl.uniprot.org/uniprot/W8F3W9 ^@ Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase class-II family. http://togogenome.org/gene/1227739:HSW_RS11835 ^@ http://purl.uniprot.org/uniprot/W8F7P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS08835 ^@ http://purl.uniprot.org/uniprot/W8EZC0 ^@ Similarity ^@ Belongs to the DNA photolyase family. http://togogenome.org/gene/1227739:HSW_RS20575 ^@ http://purl.uniprot.org/uniprot/W8FCZ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/1227739:HSW_RS08755 ^@ http://purl.uniprot.org/uniprot/W8F3D4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS04950 ^@ http://purl.uniprot.org/uniprot/W8EX11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1227739:HSW_RS07260 ^@ http://purl.uniprot.org/uniprot/W8F4T6 ^@ Cofactor|||PTM|||Subcellular Location Annotation ^@ Binds 2 heme groups per subunit.|||Binds 2 heme groups.|||Periplasm http://togogenome.org/gene/1227739:HSW_RS08090 ^@ http://purl.uniprot.org/uniprot/W8F5G0 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/1227739:HSW_RS08515 ^@ http://purl.uniprot.org/uniprot/W8EV15 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1227739:HSW_RS14375 ^@ http://purl.uniprot.org/uniprot/W8F6M9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS03545 ^@ http://purl.uniprot.org/uniprot/W8EW95 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/1227739:HSW_RS02690 ^@ http://purl.uniprot.org/uniprot/W8F1Z4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS12700 ^@ http://purl.uniprot.org/uniprot/W8F8B6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS15050 ^@ http://purl.uniprot.org/uniprot/W8F367 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family. http://togogenome.org/gene/1227739:HSW_RS14705 ^@ http://purl.uniprot.org/uniprot/W8F2V9 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS09560 ^@ http://purl.uniprot.org/uniprot/W8F684 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS22525 ^@ http://purl.uniprot.org/uniprot/W8F3G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS21630 ^@ http://purl.uniprot.org/uniprot/W8FDK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS04395 ^@ http://purl.uniprot.org/uniprot/W8EUJ1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS07070 ^@ http://purl.uniprot.org/uniprot/W8F2B9 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/1227739:HSW_RS01610 ^@ http://purl.uniprot.org/uniprot/W8ESX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS16770 ^@ http://purl.uniprot.org/uniprot/W8F066 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/1227739:HSW_RS03990 ^@ http://purl.uniprot.org/uniprot/W8F2U7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT. http://togogenome.org/gene/1227739:HSW_RS11020 ^@ http://purl.uniprot.org/uniprot/W8F4P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS13470 ^@ http://purl.uniprot.org/uniprot/W8EZN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS13550 ^@ http://purl.uniprot.org/uniprot/W8EYD2 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FBPase class 1 family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS22350 ^@ http://purl.uniprot.org/uniprot/W8F161 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21865 ^@ http://purl.uniprot.org/uniprot/W8F345 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS10375 ^@ http://purl.uniprot.org/uniprot/W8EY16 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/1227739:HSW_RS09150 ^@ http://purl.uniprot.org/uniprot/W8EX75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS07650 ^@ http://purl.uniprot.org/uniprot/W8EUI4 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/1227739:HSW_RS01540 ^@ http://purl.uniprot.org/uniprot/W8EV52 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS10990 ^@ http://purl.uniprot.org/uniprot/W8EWX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS08775 ^@ http://purl.uniprot.org/uniprot/W8F5S6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1227739:HSW_RS06415 ^@ http://purl.uniprot.org/uniprot/W8ETW5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/1227739:HSW_RS14020 ^@ http://purl.uniprot.org/uniprot/W8F903 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/1227739:HSW_RS22765 ^@ http://purl.uniprot.org/uniprot/W8F6S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS13525 ^@ http://purl.uniprot.org/uniprot/W8EYC7 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/1227739:HSW_RS01850 ^@ http://purl.uniprot.org/uniprot/W8ERA8 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS04820 ^@ http://purl.uniprot.org/uniprot/W8ESZ7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1227739:HSW_RS16140 ^@ http://purl.uniprot.org/uniprot/W8FAB2 ^@ Similarity ^@ Belongs to the DapB family. http://togogenome.org/gene/1227739:HSW_RS11285 ^@ http://purl.uniprot.org/uniprot/W8F4V2 ^@ Caution|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the IcmF family.|||Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.|||Homodimer.|||Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS04180 ^@ http://purl.uniprot.org/uniprot/W8EUF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/1227739:HSW_RS03305 ^@ http://purl.uniprot.org/uniprot/W8F2G7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1227739:HSW_RS09640 ^@ http://purl.uniprot.org/uniprot/W8F6A0 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/1227739:HSW_RS09540 ^@ http://purl.uniprot.org/uniprot/W8F3U5 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS18925 ^@ http://purl.uniprot.org/uniprot/W8F989 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1227739:HSW_RS02535 ^@ http://purl.uniprot.org/uniprot/W8ETD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS10040 ^@ http://purl.uniprot.org/uniprot/W8F457 ^@ Similarity|||Subunit ^@ Belongs to the glycosyltransferase 20 family.|||Homotetramer.|||In the C-terminal section; belongs to the trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/1227739:HSW_RS13575 ^@ http://purl.uniprot.org/uniprot/W8EYD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell inner membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. http://togogenome.org/gene/1227739:HSW_RS15095 ^@ http://purl.uniprot.org/uniprot/W8F770 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CutC family.|||Cytoplasm|||Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case. http://togogenome.org/gene/1227739:HSW_RS13990 ^@ http://purl.uniprot.org/uniprot/W8EYL1 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1227739:HSW_RS02130 ^@ http://purl.uniprot.org/uniprot/W8EZF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1227739:HSW_RS13515 ^@ http://purl.uniprot.org/uniprot/W8F259 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS21280 ^@ http://purl.uniprot.org/uniprot/W8F6Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS12930 ^@ http://purl.uniprot.org/uniprot/W8EY19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21445 ^@ http://purl.uniprot.org/uniprot/W8F2W4 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS10260 ^@ http://purl.uniprot.org/uniprot/W8F6T5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS18855 ^@ http://purl.uniprot.org/uniprot/W8F980 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1227739:HSW_RS10300 ^@ http://purl.uniprot.org/uniprot/W8EY01 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 30 family. http://togogenome.org/gene/1227739:HSW_RS07770 ^@ http://purl.uniprot.org/uniprot/W8F562 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/1227739:HSW_RS13475 ^@ http://purl.uniprot.org/uniprot/W8EYB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS15515 ^@ http://purl.uniprot.org/uniprot/W8F3D5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS04615 ^@ http://purl.uniprot.org/uniprot/W8EUN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS01535 ^@ http://purl.uniprot.org/uniprot/W8EZ35 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/1227739:HSW_RS03300 ^@ http://purl.uniprot.org/uniprot/W8ES68 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS09435 ^@ http://purl.uniprot.org/uniprot/W8EZQ3 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysD subfamily. http://togogenome.org/gene/1227739:HSW_RS21690 ^@ http://purl.uniprot.org/uniprot/W8F6Y4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/1227739:HSW_RS01865 ^@ http://purl.uniprot.org/uniprot/W8EVB8 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/1227739:HSW_RS20590 ^@ http://purl.uniprot.org/uniprot/W8F3N4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/1227739:HSW_RS02335 ^@ http://purl.uniprot.org/uniprot/W8EZL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS07875 ^@ http://purl.uniprot.org/uniprot/W8EYU7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS19295 ^@ http://purl.uniprot.org/uniprot/W8F5I2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS22440 ^@ http://purl.uniprot.org/uniprot/W8EVR2 ^@ Function|||Similarity ^@ Belongs to the peptidase S51 family.|||Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides. http://togogenome.org/gene/1227739:HSW_RS16315 ^@ http://purl.uniprot.org/uniprot/W8EZZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS14835 ^@ http://purl.uniprot.org/uniprot/W8F9J6 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/1227739:HSW_RS16150 ^@ http://purl.uniprot.org/uniprot/W8F3R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/1227739:HSW_RS21330 ^@ http://purl.uniprot.org/uniprot/W8F6Q9 ^@ Similarity ^@ Belongs to the NusB family. http://togogenome.org/gene/1227739:HSW_RS19985 ^@ http://purl.uniprot.org/uniprot/W8FA03 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/1227739:HSW_RS13035 ^@ http://purl.uniprot.org/uniprot/W8F8H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS16955 ^@ http://purl.uniprot.org/uniprot/W8F1M6 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.|||Belongs to the TPP enzyme family.|||Binds 1 FAD per subunit.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Cell membrane|||Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus. http://togogenome.org/gene/1227739:HSW_RS09160 ^@ http://purl.uniprot.org/uniprot/W8F5Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS17330 ^@ http://purl.uniprot.org/uniprot/W8F0I2 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1227739:HSW_RS23550 ^@ http://purl.uniprot.org/uniprot/W8F045 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 27 family. http://togogenome.org/gene/1227739:HSW_RS11360 ^@ http://purl.uniprot.org/uniprot/W8F4W5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS18745 ^@ http://purl.uniprot.org/uniprot/W8F1B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1227739:HSW_RS12375 ^@ http://purl.uniprot.org/uniprot/W8F1G7 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1227739:HSW_RS01815 ^@ http://purl.uniprot.org/uniprot/W8EVA9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1227739:HSW_RS14310 ^@ http://purl.uniprot.org/uniprot/W8F041 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS14320 ^@ http://purl.uniprot.org/uniprot/W8F967 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 2 subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/1227739:HSW_RS14000 ^@ http://purl.uniprot.org/uniprot/W8F6F1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS01585 ^@ http://purl.uniprot.org/uniprot/W8ESW9 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1227739:HSW_RS02820 ^@ http://purl.uniprot.org/uniprot/W8EVW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/1227739:HSW_RS09040 ^@ http://purl.uniprot.org/uniprot/W8EVB0 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1227739:HSW_RS16420 ^@ http://purl.uniprot.org/uniprot/W8FAH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS18710 ^@ http://purl.uniprot.org/uniprot/W8F569 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS14855 ^@ http://purl.uniprot.org/uniprot/W8EZ41 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS11245 ^@ http://purl.uniprot.org/uniprot/W8EYH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20270 ^@ http://purl.uniprot.org/uniprot/W8FCU0 ^@ Similarity ^@ Belongs to the UPF0337 (CsbD) family. http://togogenome.org/gene/1227739:HSW_RS10110 ^@ http://purl.uniprot.org/uniprot/W8EVX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS06005 ^@ http://purl.uniprot.org/uniprot/W8F1S6 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS10065 ^@ http://purl.uniprot.org/uniprot/W8F6K6 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS06810 ^@ http://purl.uniprot.org/uniprot/W8F4I8 ^@ Similarity ^@ Belongs to the CarB family. http://togogenome.org/gene/1227739:HSW_RS20965 ^@ http://purl.uniprot.org/uniprot/W8FD66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1227739:HSW_RS11575 ^@ http://purl.uniprot.org/uniprot/W8EX80 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/1227739:HSW_RS06610 ^@ http://purl.uniprot.org/uniprot/W8F4F4 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS17410 ^@ http://purl.uniprot.org/uniprot/W8F8I3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1227739:HSW_RS15715 ^@ http://purl.uniprot.org/uniprot/W8F0Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21035 ^@ http://purl.uniprot.org/uniprot/W8F2N7 ^@ Similarity ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/1227739:HSW_RS13700 ^@ http://purl.uniprot.org/uniprot/W8F8U7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS09490 ^@ http://purl.uniprot.org/uniprot/W8F667 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/1227739:HSW_RS05615 ^@ http://purl.uniprot.org/uniprot/W8ETJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS18690 ^@ http://purl.uniprot.org/uniprot/W8F2L4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1227739:HSW_RS17360 ^@ http://purl.uniprot.org/uniprot/W8FB32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS10075 ^@ http://purl.uniprot.org/uniprot/W8F043 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/1227739:HSW_RS13275 ^@ http://purl.uniprot.org/uniprot/W8F8L4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS05630 ^@ http://purl.uniprot.org/uniprot/W8EXJ1 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 3 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/1227739:HSW_RS19745 ^@ http://purl.uniprot.org/uniprot/W8F5S7 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/1227739:HSW_RS05930 ^@ http://purl.uniprot.org/uniprot/W8EVH2 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/1227739:HSW_RS08970 ^@ http://purl.uniprot.org/uniprot/W8EV96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03980 ^@ http://purl.uniprot.org/uniprot/W8EUC4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS00450 ^@ http://purl.uniprot.org/uniprot/W8EYF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS14390 ^@ http://purl.uniprot.org/uniprot/W8EYT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/1227739:HSW_RS15580 ^@ http://purl.uniprot.org/uniprot/W8F7E7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS13505 ^@ http://purl.uniprot.org/uniprot/W8F8R4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Homodimer.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/1227739:HSW_RS11560 ^@ http://purl.uniprot.org/uniprot/W8F503 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS18320 ^@ http://purl.uniprot.org/uniprot/W8F139 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1227739:HSW_RS01075 ^@ http://purl.uniprot.org/uniprot/W8EUU9 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/1227739:HSW_RS15520 ^@ http://purl.uniprot.org/uniprot/W8F0U8 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS10565 ^@ http://purl.uniprot.org/uniprot/W8F0G1 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/1227739:HSW_RS04725 ^@ http://purl.uniprot.org/uniprot/W8EWW4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS03875 ^@ http://purl.uniprot.org/uniprot/W8EWE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS09990 ^@ http://purl.uniprot.org/uniprot/W8EVV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS15055 ^@ http://purl.uniprot.org/uniprot/W8F0L6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/1227739:HSW_RS13025 ^@ http://purl.uniprot.org/uniprot/W8EZE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1227739:HSW_RS03630 ^@ http://purl.uniprot.org/uniprot/W8EU64 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/1227739:HSW_RS12975 ^@ http://purl.uniprot.org/uniprot/W8EY27 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/1227739:HSW_RS20100 ^@ http://purl.uniprot.org/uniprot/W8FCR5 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1227739:HSW_RS22020 ^@ http://purl.uniprot.org/uniprot/W8F755 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/1227739:HSW_RS16625 ^@ http://purl.uniprot.org/uniprot/W8F402 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1227739:HSW_RS17315 ^@ http://purl.uniprot.org/uniprot/W8F8E3 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/1227739:HSW_RS19360 ^@ http://purl.uniprot.org/uniprot/W8F9I4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1227739:HSW_RS16455 ^@ http://purl.uniprot.org/uniprot/W8F3W6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/1227739:HSW_RS01460 ^@ http://purl.uniprot.org/uniprot/W8ESU0 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/1227739:HSW_RS20800 ^@ http://purl.uniprot.org/uniprot/W8FD35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS11355 ^@ http://purl.uniprot.org/uniprot/W8F7E0 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1227739:HSW_RS24925 ^@ http://purl.uniprot.org/uniprot/W8ERK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS25010 ^@ http://purl.uniprot.org/uniprot/W8F672 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 53 family. http://togogenome.org/gene/1227739:HSW_RS20845 ^@ http://purl.uniprot.org/uniprot/W8F2J8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1227739:HSW_RS04530 ^@ http://purl.uniprot.org/uniprot/W8ESU7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1227739:HSW_RS11455 ^@ http://purl.uniprot.org/uniprot/W8F0W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 51 family.|||Cell membrane|||Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. http://togogenome.org/gene/1227739:HSW_RS18930 ^@ http://purl.uniprot.org/uniprot/W8F5A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1227739:HSW_RS10820 ^@ http://purl.uniprot.org/uniprot/W8EY95 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/1227739:HSW_RS02125 ^@ http://purl.uniprot.org/uniprot/W8F1M3 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/1227739:HSW_RS04090 ^@ http://purl.uniprot.org/uniprot/W8F0L8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1227739:HSW_RS16230 ^@ http://purl.uniprot.org/uniprot/W8F3S4 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1227739:HSW_RS07085 ^@ http://purl.uniprot.org/uniprot/W8EU90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS14215 ^@ http://purl.uniprot.org/uniprot/W8F025 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).|||Homotetramer. http://togogenome.org/gene/1227739:HSW_RS04360 ^@ http://purl.uniprot.org/uniprot/W8F0S0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1227739:HSW_RS05315 ^@ http://purl.uniprot.org/uniprot/W8ET94 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/1227739:HSW_RS08035 ^@ http://purl.uniprot.org/uniprot/W8EWM3 ^@ Function|||Similarity ^@ Belongs to the SELO family.|||Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). http://togogenome.org/gene/1227739:HSW_RS18885 ^@ http://purl.uniprot.org/uniprot/W8F984 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1227739:HSW_RS16495 ^@ http://purl.uniprot.org/uniprot/W8FAJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1227739:HSW_RS17845 ^@ http://purl.uniprot.org/uniprot/W8FBF3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/1227739:HSW_RS09885 ^@ http://purl.uniprot.org/uniprot/W8F006 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS20650 ^@ http://purl.uniprot.org/uniprot/W8F6C5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS18530 ^@ http://purl.uniprot.org/uniprot/W8F170 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1227739:HSW_RS11735 ^@ http://purl.uniprot.org/uniprot/W8EYQ6 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1227739:HSW_RS20735 ^@ http://purl.uniprot.org/uniprot/W8FAD4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/1227739:HSW_RS12410 ^@ http://purl.uniprot.org/uniprot/W8EXP1 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/1227739:HSW_RS08850 ^@ http://purl.uniprot.org/uniprot/W8F5U2 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/1227739:HSW_RS20440 ^@ http://purl.uniprot.org/uniprot/W8FCX0 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS07590 ^@ http://purl.uniprot.org/uniprot/W8EYL2 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS00475 ^@ http://purl.uniprot.org/uniprot/W8EUE6 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1227739:HSW_RS10155 ^@ http://purl.uniprot.org/uniprot/W8EXT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS00395 ^@ http://purl.uniprot.org/uniprot/W8EYE7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS13580 ^@ http://purl.uniprot.org/uniprot/W8F8S7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS18805 ^@ http://purl.uniprot.org/uniprot/W8F971 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1227739:HSW_RS12680 ^@ http://purl.uniprot.org/uniprot/W8F8B2 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/1227739:HSW_RS06740 ^@ http://purl.uniprot.org/uniprot/W8F251 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/1227739:HSW_RS17020 ^@ http://purl.uniprot.org/uniprot/W8F880 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1227739:HSW_RS22075 ^@ http://purl.uniprot.org/uniprot/W8F4H1 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1227739:HSW_RS17795 ^@ http://purl.uniprot.org/uniprot/W8F0U0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1227739:HSW_RS21655 ^@ http://purl.uniprot.org/uniprot/W8FDK9 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/1227739:HSW_RS11915 ^@ http://purl.uniprot.org/uniprot/W8F172 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/1227739:HSW_RS09065 ^@ http://purl.uniprot.org/uniprot/W8F3J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS17320 ^@ http://purl.uniprot.org/uniprot/W8F4E3 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/1227739:HSW_RS20925 ^@ http://purl.uniprot.org/uniprot/W8FD58 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1227739:HSW_RS20455 ^@ http://purl.uniprot.org/uniprot/W8F3K9 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 67 family.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS06230 ^@ http://purl.uniprot.org/uniprot/W8EXT5 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/1227739:HSW_RS04775 ^@ http://purl.uniprot.org/uniprot/W8EWX5 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS14275 ^@ http://purl.uniprot.org/uniprot/W8F957 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS03330 ^@ http://purl.uniprot.org/uniprot/W8F2H2 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS00445 ^@ http://purl.uniprot.org/uniprot/W8F0J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS05515 ^@ http://purl.uniprot.org/uniprot/W8F3W0 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS09485 ^@ http://purl.uniprot.org/uniprot/W8EXE2 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1227739:HSW_RS08250 ^@ http://purl.uniprot.org/uniprot/W8F5I9 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/1227739:HSW_RS22130 ^@ http://purl.uniprot.org/uniprot/W8F3A3 ^@ Caution|||Function|||Similarity ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). http://togogenome.org/gene/1227739:HSW_RS07730 ^@ http://purl.uniprot.org/uniprot/W8EYP2 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/1227739:HSW_RS14670 ^@ http://purl.uniprot.org/uniprot/W8EYZ8 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/1227739:HSW_RS05035 ^@ http://purl.uniprot.org/uniprot/W8EUW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/1227739:HSW_RS20445 ^@ http://purl.uniprot.org/uniprot/W8FA78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS07455 ^@ http://purl.uniprot.org/uniprot/W8F2L0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS18920 ^@ http://purl.uniprot.org/uniprot/W8FC00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/1227739:HSW_RS19380 ^@ http://purl.uniprot.org/uniprot/W8FC92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/1227739:HSW_RS16245 ^@ http://purl.uniprot.org/uniprot/W8FAD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03845 ^@ http://purl.uniprot.org/uniprot/W8F0I0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS18740 ^@ http://purl.uniprot.org/uniprot/W8F2M5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/1227739:HSW_RS13730 ^@ http://purl.uniprot.org/uniprot/W8F6A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS00510 ^@ http://purl.uniprot.org/uniprot/W8F0K6 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/1227739:HSW_RS06630 ^@ http://purl.uniprot.org/uniprot/W8EU08 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1227739:HSW_RS21660 ^@ http://purl.uniprot.org/uniprot/W8FAW8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/1227739:HSW_RS01520 ^@ http://purl.uniprot.org/uniprot/W8ESV4 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/1227739:HSW_RS06520 ^@ http://purl.uniprot.org/uniprot/W8F207 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/1227739:HSW_RS08875 ^@ http://purl.uniprot.org/uniprot/W8F3F7 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/1227739:HSW_RS17005 ^@ http://purl.uniprot.org/uniprot/W8F1N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS19485 ^@ http://purl.uniprot.org/uniprot/W8F5M5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/1227739:HSW_RS03015 ^@ http://purl.uniprot.org/uniprot/W8F050 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/1227739:HSW_RS05970 ^@ http://purl.uniprot.org/uniprot/W8ETP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS18905 ^@ http://purl.uniprot.org/uniprot/W8F5A1 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/1227739:HSW_RS18940 ^@ http://purl.uniprot.org/uniprot/W8F1F1 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS20710 ^@ http://purl.uniprot.org/uniprot/W8FAC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20010 ^@ http://purl.uniprot.org/uniprot/W8FA07 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS22025 ^@ http://purl.uniprot.org/uniprot/W8F4G2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS06680 ^@ http://purl.uniprot.org/uniprot/W8EVV6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS11950 ^@ http://purl.uniprot.org/uniprot/W8EXF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS11370 ^@ http://purl.uniprot.org/uniprot/W8EYJ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1227739:HSW_RS15440 ^@ http://purl.uniprot.org/uniprot/W8F7C7 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/1227739:HSW_RS05275 ^@ http://purl.uniprot.org/uniprot/W8EV17 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/1227739:HSW_RS16930 ^@ http://purl.uniprot.org/uniprot/W8F1M1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1227739:HSW_RS10315 ^@ http://purl.uniprot.org/uniprot/W8F4E1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/1227739:HSW_RS16950 ^@ http://purl.uniprot.org/uniprot/W8F470 ^@ Similarity ^@ Belongs to the UPF0162 family. http://togogenome.org/gene/1227739:HSW_RS16235 ^@ http://purl.uniprot.org/uniprot/W8F194 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1227739:HSW_RS11650 ^@ http://purl.uniprot.org/uniprot/W8EX91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20520 ^@ http://purl.uniprot.org/uniprot/W8F2D2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS04855 ^@ http://purl.uniprot.org/uniprot/W8EWZ1 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/1227739:HSW_RS08805 ^@ http://purl.uniprot.org/uniprot/W8F3E3 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/1227739:HSW_RS09825 ^@ http://purl.uniprot.org/uniprot/W8EVS2 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1227739:HSW_RS06790 ^@ http://purl.uniprot.org/uniprot/W8F263 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS03075 ^@ http://purl.uniprot.org/uniprot/W8ETW2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/1227739:HSW_RS19845 ^@ http://purl.uniprot.org/uniprot/W8F9T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS04620 ^@ http://purl.uniprot.org/uniprot/W8ESW5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/1227739:HSW_RS04980 ^@ http://purl.uniprot.org/uniprot/W8EX17 ^@ Similarity|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/1227739:HSW_RS17150 ^@ http://purl.uniprot.org/uniprot/W8F0E4 ^@ Similarity ^@ In the N-terminal section; belongs to the phytochrome family. http://togogenome.org/gene/1227739:HSW_RS21250 ^@ http://purl.uniprot.org/uniprot/W8F403 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1227739:HSW_RS04275 ^@ http://purl.uniprot.org/uniprot/W8EUH2 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1227739:HSW_RS15905 ^@ http://purl.uniprot.org/uniprot/W8FA74 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/1227739:HSW_RS08920 ^@ http://purl.uniprot.org/uniprot/W8F5V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS15875 ^@ http://purl.uniprot.org/uniprot/W8F118 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/1227739:HSW_RS02685 ^@ http://purl.uniprot.org/uniprot/W8ETH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS02880 ^@ http://purl.uniprot.org/uniprot/W8ERV4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS22890 ^@ http://purl.uniprot.org/uniprot/W8EZK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS12705 ^@ http://purl.uniprot.org/uniprot/W8F5T6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial microcompartment|||Belongs to the EutB family.|||Binds between the large and small subunits.|||Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.|||The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards. http://togogenome.org/gene/1227739:HSW_RS05610 ^@ http://purl.uniprot.org/uniprot/W8EVB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS19710 ^@ http://purl.uniprot.org/uniprot/W8FCG6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS09585 ^@ http://purl.uniprot.org/uniprot/W8F689 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS06755 ^@ http://purl.uniprot.org/uniprot/W8EU32 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1227739:HSW_RS08980 ^@ http://purl.uniprot.org/uniprot/W8F3H4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FBPase class 1 family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1227739:HSW_RS20420 ^@ http://purl.uniprot.org/uniprot/W8FA76 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1227739:HSW_RS11395 ^@ http://purl.uniprot.org/uniprot/W8EYJ6 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS14955 ^@ http://purl.uniprot.org/uniprot/W8F712 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS07985 ^@ http://purl.uniprot.org/uniprot/W8F309 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1227739:HSW_RS06970 ^@ http://purl.uniprot.org/uniprot/W8F299 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT. http://togogenome.org/gene/1227739:HSW_RS04555 ^@ http://purl.uniprot.org/uniprot/W8ESV2 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1227739:HSW_RS04010 ^@ http://purl.uniprot.org/uniprot/W8F2V3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1227739:HSW_RS16465 ^@ http://purl.uniprot.org/uniprot/W8F016 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/1227739:HSW_RS02060 ^@ http://purl.uniprot.org/uniprot/W8EVG1 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/1227739:HSW_RS10295 ^@ http://purl.uniprot.org/uniprot/W8F0B5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 30 family. http://togogenome.org/gene/1227739:HSW_RS11855 ^@ http://purl.uniprot.org/uniprot/W8EXD3 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS07995 ^@ http://purl.uniprot.org/uniprot/W8F5E4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1227739:HSW_RS03740 ^@ http://purl.uniprot.org/uniprot/W8F2Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS02740 ^@ http://purl.uniprot.org/uniprot/W8EZV7 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/1227739:HSW_RS23230 ^@ http://purl.uniprot.org/uniprot/W8FDA2 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/1227739:HSW_RS21880 ^@ http://purl.uniprot.org/uniprot/W8F727 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21335 ^@ http://purl.uniprot.org/uniprot/W8F417 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1227739:HSW_RS20290 ^@ http://purl.uniprot.org/uniprot/W8F290 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1227739:HSW_RS19300 ^@ http://purl.uniprot.org/uniprot/W8F2X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03620 ^@ http://purl.uniprot.org/uniprot/W8F0E0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1227739:HSW_RS00375 ^@ http://purl.uniprot.org/uniprot/W8EUC5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS03340 ^@ http://purl.uniprot.org/uniprot/W8EW66 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1227739:HSW_RS21135 ^@ http://purl.uniprot.org/uniprot/W8F2Q9 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS19880 ^@ http://purl.uniprot.org/uniprot/W8F3B9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/1227739:HSW_RS13555 ^@ http://purl.uniprot.org/uniprot/W8F8S3 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1227739:HSW_RS10435 ^@ http://purl.uniprot.org/uniprot/W8F6W9 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/1227739:HSW_RS03265 ^@ http://purl.uniprot.org/uniprot/W8EW57 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/1227739:HSW_RS07680 ^@ http://purl.uniprot.org/uniprot/W8F537 ^@ Similarity ^@ Belongs to the CsgA/CsgB family. http://togogenome.org/gene/1227739:HSW_RS07720 ^@ http://purl.uniprot.org/uniprot/W8F550 ^@ Function|||Similarity ^@ A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.|||Belongs to the NifU family. http://togogenome.org/gene/1227739:HSW_RS01410 ^@ http://purl.uniprot.org/uniprot/W8ESS9 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/1227739:HSW_RS19320 ^@ http://purl.uniprot.org/uniprot/W8F2X9 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1227739:HSW_RS00325 ^@ http://purl.uniprot.org/uniprot/W8F0G4 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/1227739:HSW_RS11210 ^@ http://purl.uniprot.org/uniprot/W8F7B5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1227739:HSW_RS09570 ^@ http://purl.uniprot.org/uniprot/W8EZT5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS11135 ^@ http://purl.uniprot.org/uniprot/W8F7A0 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/1227739:HSW_RS03030 ^@ http://purl.uniprot.org/uniprot/W8ES20 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/1227739:HSW_RS04070 ^@ http://purl.uniprot.org/uniprot/W8EWH1 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/1227739:HSW_RS02830 ^@ http://purl.uniprot.org/uniprot/W8ETL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/1227739:HSW_RS07375 ^@ http://purl.uniprot.org/uniprot/W8F4W3 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/1227739:HSW_RS03860 ^@ http://purl.uniprot.org/uniprot/W8ESG6 ^@ Similarity ^@ Belongs to the MreC family. http://togogenome.org/gene/1227739:HSW_RS19250 ^@ http://purl.uniprot.org/uniprot/W8F2W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS03960 ^@ http://purl.uniprot.org/uniprot/W8ESI4 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1227739:HSW_RS09035 ^@ http://purl.uniprot.org/uniprot/W8EX54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1227739:HSW_RS15490 ^@ http://purl.uniprot.org/uniprot/W8F3D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS21255 ^@ http://purl.uniprot.org/uniprot/W8F2T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS06060 ^@ http://purl.uniprot.org/uniprot/W8EXQ4 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/1227739:HSW_RS05150 ^@ http://purl.uniprot.org/uniprot/W8F198 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03655 ^@ http://purl.uniprot.org/uniprot/W8ESC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS16250 ^@ http://purl.uniprot.org/uniprot/W8F7R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Membrane http://togogenome.org/gene/1227739:HSW_RS03410 ^@ http://purl.uniprot.org/uniprot/W8EW74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS10330 ^@ http://purl.uniprot.org/uniprot/W8EWJ3 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS01450 ^@ http://purl.uniprot.org/uniprot/W8EZ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS02355 ^@ http://purl.uniprot.org/uniprot/W8F1S4 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/1227739:HSW_RS17850 ^@ http://purl.uniprot.org/uniprot/W8F8R6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/1227739:HSW_RS05965 ^@ http://purl.uniprot.org/uniprot/W8EVH7 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1227739:HSW_RS10275 ^@ http://purl.uniprot.org/uniprot/W8EXZ6 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS14465 ^@ http://purl.uniprot.org/uniprot/W8F998 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS19965 ^@ http://purl.uniprot.org/uniprot/W8F3D6 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/1227739:HSW_RS05490 ^@ http://purl.uniprot.org/uniprot/W8F3V3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS16020 ^@ http://purl.uniprot.org/uniprot/W8F7M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS21240 ^@ http://purl.uniprot.org/uniprot/W8FAN4 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/1227739:HSW_RS19420 ^@ http://purl.uniprot.org/uniprot/W8F2Z7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS07420 ^@ http://purl.uniprot.org/uniprot/W8EUE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS01645 ^@ http://purl.uniprot.org/uniprot/W8F1D5 ^@ Function|||Similarity ^@ Belongs to the RlpA family.|||Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. http://togogenome.org/gene/1227739:HSW_RS13255 ^@ http://purl.uniprot.org/uniprot/W8EY76 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1227739:HSW_RS19195 ^@ http://purl.uniprot.org/uniprot/W8F5G1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/1227739:HSW_RS02935 ^@ http://purl.uniprot.org/uniprot/W8F005 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS04075 ^@ http://purl.uniprot.org/uniprot/W8EUE0 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/1227739:HSW_RS06600 ^@ http://purl.uniprot.org/uniprot/W8EVU1 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1227739:HSW_RS15995 ^@ http://purl.uniprot.org/uniprot/W8F3M5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1227739:HSW_RS09275 ^@ http://purl.uniprot.org/uniprot/W8F621 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS05055 ^@ http://purl.uniprot.org/uniprot/W8EX33 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1227739:HSW_RS12075 ^@ http://purl.uniprot.org/uniprot/W8EXH8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1227739:HSW_RS19240 ^@ http://purl.uniprot.org/uniprot/W8F9F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21440 ^@ http://purl.uniprot.org/uniprot/W8F439 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS02520 ^@ http://purl.uniprot.org/uniprot/W8F1W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS18030 ^@ http://purl.uniprot.org/uniprot/W8F292 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1227739:HSW_RS03120 ^@ http://purl.uniprot.org/uniprot/W8EW38 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS13335 ^@ http://purl.uniprot.org/uniprot/W8EY93 ^@ Function|||Similarity ^@ Belongs to the peptidase S46 family.|||Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. http://togogenome.org/gene/1227739:HSW_RS13690 ^@ http://purl.uniprot.org/uniprot/W8EZS8 ^@ Cofactor|||Similarity ^@ Belongs to the fatty acid desaturase type 2 family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/1227739:HSW_RS05020 ^@ http://purl.uniprot.org/uniprot/W8F3E9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS18230 ^@ http://purl.uniprot.org/uniprot/W8F8W8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/1227739:HSW_RS03295 ^@ http://purl.uniprot.org/uniprot/W8EU02 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1227739:HSW_RS08900 ^@ http://purl.uniprot.org/uniprot/W8F3G1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS09980 ^@ http://purl.uniprot.org/uniprot/W8F024 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS03155 ^@ http://purl.uniprot.org/uniprot/W8ES43 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1227739:HSW_RS18990 ^@ http://purl.uniprot.org/uniprot/W8F1G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS13055 ^@ http://purl.uniprot.org/uniprot/W8F8H7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS18390 ^@ http://purl.uniprot.org/uniprot/W8F2F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0187 family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS10880 ^@ http://purl.uniprot.org/uniprot/W8EWU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS12940 ^@ http://purl.uniprot.org/uniprot/W8F5X1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/1227739:HSW_RS15915 ^@ http://purl.uniprot.org/uniprot/W8F128 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS08950 ^@ http://purl.uniprot.org/uniprot/W8F5W0 ^@ Similarity ^@ Belongs to the UxaA family. http://togogenome.org/gene/1227739:HSW_RS16540 ^@ http://purl.uniprot.org/uniprot/W8F027 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS01800 ^@ http://purl.uniprot.org/uniprot/W8ET04 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1227739:HSW_RS13960 ^@ http://purl.uniprot.org/uniprot/W8EZY2 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1227739:HSW_RS14475 ^@ http://purl.uniprot.org/uniprot/W8F075 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS02025 ^@ http://purl.uniprot.org/uniprot/W8F1K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS09745 ^@ http://purl.uniprot.org/uniprot/W8EZX5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 100 family. http://togogenome.org/gene/1227739:HSW_RS10010 ^@ http://purl.uniprot.org/uniprot/W8F6J2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS22100 ^@ http://purl.uniprot.org/uniprot/W8F4H7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/1227739:HSW_RS13115 ^@ http://purl.uniprot.org/uniprot/W8F8I5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/1227739:HSW_RS08365 ^@ http://purl.uniprot.org/uniprot/W8EUY8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS09085 ^@ http://purl.uniprot.org/uniprot/W8EVC1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS12495 ^@ http://purl.uniprot.org/uniprot/W8F5L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS01845 ^@ http://purl.uniprot.org/uniprot/W8ET12 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS12505 ^@ http://purl.uniprot.org/uniprot/W8EZ48 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/1227739:HSW_RS18285 ^@ http://purl.uniprot.org/uniprot/W8F4Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS20755 ^@ http://purl.uniprot.org/uniprot/W8FD26 ^@ Similarity ^@ Belongs to the peptidase M4 family. http://togogenome.org/gene/1227739:HSW_RS21680 ^@ http://purl.uniprot.org/uniprot/W8FDL4 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS16580 ^@ http://purl.uniprot.org/uniprot/W8F1F7 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/1227739:HSW_RS18125 ^@ http://purl.uniprot.org/uniprot/W8F4W0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueG family.|||Binds 2 [4Fe-4S] clusters per monomer.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS12995 ^@ http://purl.uniprot.org/uniprot/W8EZE1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1227739:HSW_RS12560 ^@ http://purl.uniprot.org/uniprot/W8EXS5 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/1227739:HSW_RS22930 ^@ http://purl.uniprot.org/uniprot/W8EYT0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS14900 ^@ http://purl.uniprot.org/uniprot/W8F0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS01415 ^@ http://purl.uniprot.org/uniprot/W8ER12 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS00590 ^@ http://purl.uniprot.org/uniprot/W8ESB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.|||Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS11220 ^@ http://purl.uniprot.org/uniprot/W8EYH0 ^@ Similarity ^@ Belongs to the peptidase S1B family. http://togogenome.org/gene/1227739:HSW_RS11120 ^@ http://purl.uniprot.org/uniprot/W8F0P8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/1227739:HSW_RS20985 ^@ http://purl.uniprot.org/uniprot/W8F2M6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/1227739:HSW_RS20700 ^@ http://purl.uniprot.org/uniprot/W8F2G9 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/1227739:HSW_RS01575 ^@ http://purl.uniprot.org/uniprot/W8EZ45 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS05470 ^@ http://purl.uniprot.org/uniprot/W8F1J7 ^@ Similarity ^@ Belongs to the peptidase M42 family. http://togogenome.org/gene/1227739:HSW_RS10945 ^@ http://purl.uniprot.org/uniprot/W8F759 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1227739:HSW_RS10030 ^@ http://purl.uniprot.org/uniprot/W8EVW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS17745 ^@ http://purl.uniprot.org/uniprot/W8F244 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS11480 ^@ http://purl.uniprot.org/uniprot/W8F0X1 ^@ Similarity ^@ Belongs to the type IB topoisomerase family. http://togogenome.org/gene/1227739:HSW_RS21720 ^@ http://purl.uniprot.org/uniprot/W8F316 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS05960 ^@ http://purl.uniprot.org/uniprot/W8EXN7 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1227739:HSW_RS15485 ^@ http://purl.uniprot.org/uniprot/W8F7D4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/1227739:HSW_RS05015 ^@ http://purl.uniprot.org/uniprot/W8ET31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS08890 ^@ http://purl.uniprot.org/uniprot/W8EV81 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/1227739:HSW_RS01550 ^@ http://purl.uniprot.org/uniprot/W8EZ39 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1227739:HSW_RS01560 ^@ http://purl.uniprot.org/uniprot/W8ESW4 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1227739:HSW_RS01945 ^@ http://purl.uniprot.org/uniprot/W8ERC7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1227739:HSW_RS20285 ^@ http://purl.uniprot.org/uniprot/W8F3I0 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/1227739:HSW_RS06795 ^@ http://purl.uniprot.org/uniprot/W8EY33 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS01370 ^@ http://purl.uniprot.org/uniprot/W8EZ00 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/1227739:HSW_RS20885 ^@ http://purl.uniprot.org/uniprot/W8F6H3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/1227739:HSW_RS18045 ^@ http://purl.uniprot.org/uniprot/W8F8U5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1227739:HSW_RS04665 ^@ http://purl.uniprot.org/uniprot/W8EUP0 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/1227739:HSW_RS21795 ^@ http://purl.uniprot.org/uniprot/W8F329 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS10970 ^@ http://purl.uniprot.org/uniprot/W8F764 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/1227739:HSW_RS13895 ^@ http://purl.uniprot.org/uniprot/W8F8X8 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/1227739:HSW_RS16895 ^@ http://purl.uniprot.org/uniprot/W8F857 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/1227739:HSW_RS04440 ^@ http://purl.uniprot.org/uniprot/W8ESS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1227739:HSW_RS20210 ^@ http://purl.uniprot.org/uniprot/W8F3G8 ^@ Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/1227739:HSW_RS14710 ^@ http://purl.uniprot.org/uniprot/W8F0C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS03935 ^@ http://purl.uniprot.org/uniprot/W8EUB6 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1227739:HSW_RS19325 ^@ http://purl.uniprot.org/uniprot/W8F1L8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/1227739:HSW_RS08305 ^@ http://purl.uniprot.org/uniprot/W8F358 ^@ Similarity ^@ Belongs to the hyi family. http://togogenome.org/gene/1227739:HSW_RS06165 ^@ http://purl.uniprot.org/uniprot/W8ETS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS05115 ^@ http://purl.uniprot.org/uniprot/W8ET51 ^@ Function|||Similarity ^@ Belongs to the peptidase S46 family.|||Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. http://togogenome.org/gene/1227739:HSW_RS15375 ^@ http://purl.uniprot.org/uniprot/W8F7B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0382 family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS14455 ^@ http://purl.uniprot.org/uniprot/W8F070 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS01165 ^@ http://purl.uniprot.org/uniprot/W8EYW7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1227739:HSW_RS07060 ^@ http://purl.uniprot.org/uniprot/W8EU85 ^@ Function|||Similarity ^@ Belongs to the HscB family.|||Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA. http://togogenome.org/gene/1227739:HSW_RS15740 ^@ http://purl.uniprot.org/uniprot/W8EZP0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/1227739:HSW_RS07725 ^@ http://purl.uniprot.org/uniprot/W8F2S3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/1227739:HSW_RS10530 ^@ http://purl.uniprot.org/uniprot/W8F6Y7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1227739:HSW_RS06800 ^@ http://purl.uniprot.org/uniprot/W8EVX9 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1227739:HSW_RS08915 ^@ http://purl.uniprot.org/uniprot/W8EV85 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the KduI family.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. http://togogenome.org/gene/1227739:HSW_RS17055 ^@ http://purl.uniprot.org/uniprot/W8F1P4 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/1227739:HSW_RS16055 ^@ http://purl.uniprot.org/uniprot/W8F7N2 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.|||Binds 1 NADP(+) per subunit.|||Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.|||Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.|||Homopentamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS08810 ^@ http://purl.uniprot.org/uniprot/W8EZB5 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/1227739:HSW_RS18755 ^@ http://purl.uniprot.org/uniprot/W8F962 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1227739:HSW_RS19955 ^@ http://purl.uniprot.org/uniprot/W8F9Z8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. http://togogenome.org/gene/1227739:HSW_RS00345 ^@ http://purl.uniprot.org/uniprot/W8F0H1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/1227739:HSW_RS15030 ^@ http://purl.uniprot.org/uniprot/W8F362 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS15730 ^@ http://purl.uniprot.org/uniprot/W8F3H0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS06820 ^@ http://purl.uniprot.org/uniprot/W8F267 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.|||Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.|||Homotrimer. http://togogenome.org/gene/1227739:HSW_RS01890 ^@ http://purl.uniprot.org/uniprot/W8EVC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS14180 ^@ http://purl.uniprot.org/uniprot/W8F6I9 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS15775 ^@ http://purl.uniprot.org/uniprot/W8F3H8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1227739:HSW_RS17010 ^@ http://purl.uniprot.org/uniprot/W8F0A9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1227739:HSW_RS03205 ^@ http://purl.uniprot.org/uniprot/W8F2E8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1227739:HSW_RS04920 ^@ http://purl.uniprot.org/uniprot/W8F145 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1227739:HSW_RS10240 ^@ http://purl.uniprot.org/uniprot/W8F4B8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS09890 ^@ http://purl.uniprot.org/uniprot/W8EXM9 ^@ Similarity ^@ Belongs to the Lgt family. http://togogenome.org/gene/1227739:HSW_RS01765 ^@ http://purl.uniprot.org/uniprot/W8F1F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS21180 ^@ http://purl.uniprot.org/uniprot/W8F2R9 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1227739:HSW_RS20980 ^@ http://purl.uniprot.org/uniprot/W8F3U9 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/1227739:HSW_RS15885 ^@ http://purl.uniprot.org/uniprot/W8FA70 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/1227739:HSW_RS08025 ^@ http://purl.uniprot.org/uniprot/W8F318 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1227739:HSW_RS11230 ^@ http://purl.uniprot.org/uniprot/W8F7B9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS18225 ^@ http://purl.uniprot.org/uniprot/W8FBL7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS17050 ^@ http://purl.uniprot.org/uniprot/W8F491 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS11655 ^@ http://purl.uniprot.org/uniprot/W8F7J9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1227739:HSW_RS11515 ^@ http://purl.uniprot.org/uniprot/W8EX68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS15855 ^@ http://purl.uniprot.org/uniprot/W8EZR1 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/1227739:HSW_RS20870 ^@ http://purl.uniprot.org/uniprot/W8F2K3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1227739:HSW_RS16350 ^@ http://purl.uniprot.org/uniprot/W8F7T7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/1227739:HSW_RS12015 ^@ http://purl.uniprot.org/uniprot/W8F193 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1227739:HSW_RS09660 ^@ http://purl.uniprot.org/uniprot/W8EVP1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1227739:HSW_RS05155 ^@ http://purl.uniprot.org/uniprot/W8EX52 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/1227739:HSW_RS15610 ^@ http://purl.uniprot.org/uniprot/W8F3F0 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/1227739:HSW_RS01930 ^@ http://purl.uniprot.org/uniprot/W8EZA9 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1227739:HSW_RS02650 ^@ http://purl.uniprot.org/uniprot/W8EZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS18325 ^@ http://purl.uniprot.org/uniprot/W8FBN4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1227739:HSW_RS04770 ^@ http://purl.uniprot.org/uniprot/W8F115 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS07620 ^@ http://purl.uniprot.org/uniprot/W8EWB9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1227739:HSW_RS19890 ^@ http://purl.uniprot.org/uniprot/W8FCN3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1227739:HSW_RS16775 ^@ http://purl.uniprot.org/uniprot/W8FAP7 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/1227739:HSW_RS21310 ^@ http://purl.uniprot.org/uniprot/W8F413 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS03490 ^@ http://purl.uniprot.org/uniprot/W8F2K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/1227739:HSW_RS04420 ^@ http://purl.uniprot.org/uniprot/W8EUJ5 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS12535 ^@ http://purl.uniprot.org/uniprot/W8EZ52 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1227739:HSW_RS04050 ^@ http://purl.uniprot.org/uniprot/W8EUD7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1227739:HSW_RS06715 ^@ http://purl.uniprot.org/uniprot/W8F245 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/1227739:HSW_RS09210 ^@ http://purl.uniprot.org/uniprot/W8F606 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS18720 ^@ http://purl.uniprot.org/uniprot/W8F1B1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1227739:HSW_RS03195 ^@ http://purl.uniprot.org/uniprot/W8ETY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS03650 ^@ http://purl.uniprot.org/uniprot/W8EU66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS05880 ^@ http://purl.uniprot.org/uniprot/W8EVG2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1227739:HSW_RS15480 ^@ http://purl.uniprot.org/uniprot/W8F9Z2 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/1227739:HSW_RS16185 ^@ http://purl.uniprot.org/uniprot/W8FAC6 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).|||Homodimer.|||In the C-terminal section; belongs to the MurCDEF family. http://togogenome.org/gene/1227739:HSW_RS22490 ^@ http://purl.uniprot.org/uniprot/W8ESM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreD family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/1227739:HSW_RS18825 ^@ http://purl.uniprot.org/uniprot/W8FBY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1227739:HSW_RS04460 ^@ http://purl.uniprot.org/uniprot/W8EUK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KdpA family.|||Cell membrane|||Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.|||The system is composed of three essential subunits: KdpA, KdpB and KdpC. http://togogenome.org/gene/1227739:HSW_RS21930 ^@ http://purl.uniprot.org/uniprot/W8F735 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS09300 ^@ http://purl.uniprot.org/uniprot/W8F3P7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS18790 ^@ http://purl.uniprot.org/uniprot/W8F2N5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1227739:HSW_RS19160 ^@ http://purl.uniprot.org/uniprot/W8F2U9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family. http://togogenome.org/gene/1227739:HSW_RS15815 ^@ http://purl.uniprot.org/uniprot/W8FA57 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1227739:HSW_RS09060 ^@ http://purl.uniprot.org/uniprot/W8F5X9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/1227739:HSW_RS06555 ^@ http://purl.uniprot.org/uniprot/W8ETZ4 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS05000 ^@ http://purl.uniprot.org/uniprot/W8F164 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/1227739:HSW_RS19705 ^@ http://purl.uniprot.org/uniprot/W8F1U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/1227739:HSW_RS03175 ^@ http://purl.uniprot.org/uniprot/W8ES46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane|||Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. http://togogenome.org/gene/1227739:HSW_RS19855 ^@ http://purl.uniprot.org/uniprot/W8F3A0 ^@ Similarity ^@ Belongs to the AIR synthase family. http://togogenome.org/gene/1227739:HSW_RS09105 ^@ http://purl.uniprot.org/uniprot/W8EX64 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/1227739:HSW_RS06675 ^@ http://purl.uniprot.org/uniprot/W8EY10 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/1227739:HSW_RS15625 ^@ http://purl.uniprot.org/uniprot/W8F7F4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS00945 ^@ http://purl.uniprot.org/uniprot/W8ESI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS10935 ^@ http://purl.uniprot.org/uniprot/W8EYB5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/1227739:HSW_RS03925 ^@ http://purl.uniprot.org/uniprot/W8F0J2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1227739:HSW_RS11750 ^@ http://purl.uniprot.org/uniprot/W8F543 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS11945 ^@ http://purl.uniprot.org/uniprot/W8EYU1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/1227739:HSW_RS10080 ^@ http://purl.uniprot.org/uniprot/W8EXS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.|||Cell membrane http://togogenome.org/gene/1227739:HSW_RS19935 ^@ http://purl.uniprot.org/uniprot/W8F9Z3 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS09780 ^@ http://purl.uniprot.org/uniprot/W8EVR5 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/1227739:HSW_RS07610 ^@ http://purl.uniprot.org/uniprot/W8F2P6 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/1227739:HSW_RS17985 ^@ http://purl.uniprot.org/uniprot/W8F0X8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1227739:HSW_RS17130 ^@ http://purl.uniprot.org/uniprot/W8FAY0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1227739:HSW_RS04975 ^@ http://purl.uniprot.org/uniprot/W8F158 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/1227739:HSW_RS07230 ^@ http://purl.uniprot.org/uniprot/W8EW51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/1227739:HSW_RS05600 ^@ http://purl.uniprot.org/uniprot/W8F1L6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/1227739:HSW_RS21805 ^@ http://purl.uniprot.org/uniprot/W8FAZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS14725 ^@ http://purl.uniprot.org/uniprot/W8F2W3 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/1227739:HSW_RS20485 ^@ http://purl.uniprot.org/uniprot/W8FA84 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1227739:HSW_RS11200 ^@ http://purl.uniprot.org/uniprot/W8EYG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAK/KUP transporter (TC 2.A.72) family.|||Cell membrane|||Membrane|||Transport of potassium into the cell. http://togogenome.org/gene/1227739:HSW_RS17390 ^@ http://purl.uniprot.org/uniprot/W8F8G2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS00910 ^@ http://purl.uniprot.org/uniprot/W8EQR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS02320 ^@ http://purl.uniprot.org/uniprot/W8ET97 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1227739:HSW_RS14095 ^@ http://purl.uniprot.org/uniprot/W8F918 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1227739:HSW_RS14930 ^@ http://purl.uniprot.org/uniprot/W8F310 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS07175 ^@ http://purl.uniprot.org/uniprot/W8EYB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/1227739:HSW_RS06345 ^@ http://purl.uniprot.org/uniprot/W8ETV1 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/1227739:HSW_RS00845 ^@ http://purl.uniprot.org/uniprot/W8EQQ5 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS14800 ^@ http://purl.uniprot.org/uniprot/W8F0E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20645 ^@ http://purl.uniprot.org/uniprot/W8FAB3 ^@ Similarity ^@ Belongs to the BshC family. http://togogenome.org/gene/1227739:HSW_RS21045 ^@ http://purl.uniprot.org/uniprot/W8FAJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS20675 ^@ http://purl.uniprot.org/uniprot/W8F3Q0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/1227739:HSW_RS03785 ^@ http://purl.uniprot.org/uniprot/W8ESF0 ^@ Similarity ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. http://togogenome.org/gene/1227739:HSW_RS09705 ^@ http://purl.uniprot.org/uniprot/W8EXI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS04175 ^@ http://purl.uniprot.org/uniprot/W8EWI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreF family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/1227739:HSW_RS06845 ^@ http://purl.uniprot.org/uniprot/W8F272 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/1227739:HSW_RS07750 ^@ http://purl.uniprot.org/uniprot/W8F2T0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS14635 ^@ http://purl.uniprot.org/uniprot/W8F2U4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1227739:HSW_RS14305 ^@ http://purl.uniprot.org/uniprot/W8F2L7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS11920 ^@ http://purl.uniprot.org/uniprot/W8EYT7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/1227739:HSW_RS18965 ^@ http://purl.uniprot.org/uniprot/W8F1F6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1227739:HSW_RS07775 ^@ http://purl.uniprot.org/uniprot/W8F2T4 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1227739:HSW_RS05430 ^@ http://purl.uniprot.org/uniprot/W8EV86 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1227739:HSW_RS06650 ^@ http://purl.uniprot.org/uniprot/W8EVV1 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1227739:HSW_RS16285 ^@ http://purl.uniprot.org/uniprot/W8F1A1 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit A family. http://togogenome.org/gene/1227739:HSW_RS10125 ^@ http://purl.uniprot.org/uniprot/W8F052 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS05895 ^@ http://purl.uniprot.org/uniprot/W8F1Q9 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/1227739:HSW_RS03230 ^@ http://purl.uniprot.org/uniprot/W8F2F2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1227739:HSW_RS23035 ^@ http://purl.uniprot.org/uniprot/W8F8F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1227739:HSW_RS15575 ^@ http://purl.uniprot.org/uniprot/W8FA09 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1227739:HSW_RS18815 ^@ http://purl.uniprot.org/uniprot/W8F2P0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1227739:HSW_RS00960 ^@ http://purl.uniprot.org/uniprot/W8EUS3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1227739:HSW_RS05005 ^@ http://purl.uniprot.org/uniprot/W8EX22 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/1227739:HSW_RS17355 ^@ http://purl.uniprot.org/uniprot/W8F0I6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS16260 ^@ http://purl.uniprot.org/uniprot/W8F197 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS11850 ^@ http://purl.uniprot.org/uniprot/W8EYS6 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/1227739:HSW_RS03765 ^@ http://purl.uniprot.org/uniprot/W8F2Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmC/CycZ/HelC family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS12090 ^@ http://purl.uniprot.org/uniprot/W8F1A9 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/1227739:HSW_RS18870 ^@ http://purl.uniprot.org/uniprot/W8F1E1 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1227739:HSW_RS04895 ^@ http://purl.uniprot.org/uniprot/W8F3C2 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/1227739:HSW_RS02865 ^@ http://purl.uniprot.org/uniprot/W8EZY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1227739:HSW_RS14925 ^@ http://purl.uniprot.org/uniprot/W8F708 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS17730 ^@ http://purl.uniprot.org/uniprot/W8FBD1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1227739:HSW_RS15620 ^@ http://purl.uniprot.org/uniprot/W8FA18 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1227739:HSW_RS21975 ^@ http://purl.uniprot.org/uniprot/W8FB35 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/1227739:HSW_RS11315 ^@ http://purl.uniprot.org/uniprot/W8F0T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/1227739:HSW_RS10515 ^@ http://purl.uniprot.org/uniprot/W8F4H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L/F-transferase family.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. http://togogenome.org/gene/1227739:HSW_RS19585 ^@ http://purl.uniprot.org/uniprot/W8FCD8 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/1227739:HSW_RS18840 ^@ http://purl.uniprot.org/uniprot/W8F2P5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1227739:HSW_RS03900 ^@ http://purl.uniprot.org/uniprot/W8F0I9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1227739:HSW_RS02835 ^@ http://purl.uniprot.org/uniprot/W8ERU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/1227739:HSW_RS18540 ^@ http://purl.uniprot.org/uniprot/W8F922 ^@ Similarity ^@ Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family. http://togogenome.org/gene/1227739:HSW_RS21870 ^@ http://purl.uniprot.org/uniprot/W8FDQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS22270 ^@ http://purl.uniprot.org/uniprot/W8EQ76 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1227739:HSW_RS09420 ^@ http://purl.uniprot.org/uniprot/W8EVJ0 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 FMN per subunit. http://togogenome.org/gene/1227739:HSW_RS21910 ^@ http://purl.uniprot.org/uniprot/W8F4D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS20490 ^@ http://purl.uniprot.org/uniprot/W8F696 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS21840 ^@ http://purl.uniprot.org/uniprot/W8F4C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/1227739:HSW_RS04370 ^@ http://purl.uniprot.org/uniprot/W8EUI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/1227739:HSW_RS01735 ^@ http://purl.uniprot.org/uniprot/W8ESZ2 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/1227739:HSW_RS12580 ^@ http://purl.uniprot.org/uniprot/W8EZ75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1227739:HSW_RS18680 ^@ http://purl.uniprot.org/uniprot/W8F950 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1227739:HSW_RS11160 ^@ http://purl.uniprot.org/uniprot/W8F7A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1227739:HSW_RS07050 ^@ http://purl.uniprot.org/uniprot/W8EW26 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. http://togogenome.org/gene/1227739:HSW_RS08925 ^@ http://purl.uniprot.org/uniprot/W8F3G6 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/1227739:HSW_RS01425 ^@ http://purl.uniprot.org/uniprot/W8EZ14 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/1227739:HSW_RS21155 ^@ http://purl.uniprot.org/uniprot/W8F3Y2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1227739:HSW_RS20145 ^@ http://purl.uniprot.org/uniprot/W8F3F8 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1227739:HSW_RS04710 ^@ http://purl.uniprot.org/uniprot/W8EUP6 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/1227739:HSW_RS05065 ^@ http://purl.uniprot.org/uniprot/W8ET40 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1227739:HSW_RS01995 ^@ http://purl.uniprot.org/uniprot/W8ERD7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 3-HAO family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. http://togogenome.org/gene/1227739:HSW_RS15920 ^@ http://purl.uniprot.org/uniprot/W8EZS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. http://togogenome.org/gene/1227739:HSW_RS03955 ^@ http://purl.uniprot.org/uniprot/W8EWF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS03095 ^@ http://purl.uniprot.org/uniprot/W8EW34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS16385 ^@ http://purl.uniprot.org/uniprot/W8F1B9 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/1227739:HSW_RS19145 ^@ http://purl.uniprot.org/uniprot/W8FC44 ^@ Similarity ^@ Belongs to the phosphosulfolactate synthase family. http://togogenome.org/gene/1227739:HSW_RS13420 ^@ http://purl.uniprot.org/uniprot/W8EZM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. TCR/Tet family.|||Membrane http://togogenome.org/gene/1227739:HSW_RS21055 ^@ http://purl.uniprot.org/uniprot/W8F3W3 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/1227739:HSW_RS19465 ^@ http://purl.uniprot.org/uniprot/W8F307 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1227739:HSW_RS02135 ^@ http://purl.uniprot.org/uniprot/W8EVH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1227739:HSW_RS05675 ^@ http://purl.uniprot.org/uniprot/W8F1M5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/1227739:HSW_RS15140 ^@ http://purl.uniprot.org/uniprot/W8F9U1 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family.