http://togogenome.org/gene/1184251:TCELL_RS03320 ^@ http://purl.uniprot.org/uniprot/I3TE67 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/1184251:TCELL_RS05735 ^@ http://purl.uniprot.org/uniprot/I3TFK2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1184251:TCELL_RS01625 ^@ http://purl.uniprot.org/uniprot/I3TDA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/1184251:TCELL_RS04720 ^@ http://purl.uniprot.org/uniprot/I3TEZ5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1184251:TCELL_RS06505 ^@ http://purl.uniprot.org/uniprot/I3TG05 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS03520 ^@ http://purl.uniprot.org/uniprot/I3TEA6 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/1184251:TCELL_RS00780 ^@ http://purl.uniprot.org/uniprot/I3TCT2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1184251:TCELL_RS03125 ^@ http://purl.uniprot.org/uniprot/I3TE33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS07520 ^@ http://purl.uniprot.org/uniprot/I3TFT6 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/1184251:TCELL_RS02910 ^@ http://purl.uniprot.org/uniprot/I3TDZ3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS05795 ^@ http://purl.uniprot.org/uniprot/I3TFL4 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/1184251:TCELL_RS01735 ^@ http://purl.uniprot.org/uniprot/I3TDC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/1184251:TCELL_RS04290 ^@ http://purl.uniprot.org/uniprot/I3TEQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS05625 ^@ http://purl.uniprot.org/uniprot/I3TFI0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/1184251:TCELL_RS05265 ^@ http://purl.uniprot.org/uniprot/I3TFA3 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1184251:TCELL_RS00935 ^@ http://purl.uniprot.org/uniprot/I3TCW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS00850 ^@ http://purl.uniprot.org/uniprot/I3TCU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1184251:TCELL_RS00225 ^@ http://purl.uniprot.org/uniprot/I3TCI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02135 ^@ http://purl.uniprot.org/uniprot/I3TDJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS04775 ^@ http://purl.uniprot.org/uniprot/I3TF06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS05130 ^@ http://purl.uniprot.org/uniprot/I3TF74 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS04160 ^@ http://purl.uniprot.org/uniprot/I3TEN3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS04365 ^@ http://purl.uniprot.org/uniprot/I3TES3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS04550 ^@ http://purl.uniprot.org/uniprot/I3TEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS05415 ^@ http://purl.uniprot.org/uniprot/I3TFD6 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1184251:TCELL_RS02425 ^@ http://purl.uniprot.org/uniprot/I3TDQ1 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/1184251:TCELL_RS02385 ^@ http://purl.uniprot.org/uniprot/I3TDP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/1184251:TCELL_RS00860 ^@ http://purl.uniprot.org/uniprot/I3TCU9 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS05045 ^@ http://purl.uniprot.org/uniprot/I3TF57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS00015 ^@ http://purl.uniprot.org/uniprot/I3TCE0 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/1184251:TCELL_RS01290 ^@ http://purl.uniprot.org/uniprot/I3TD34 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/1184251:TCELL_RS05950 ^@ http://purl.uniprot.org/uniprot/I3TFP5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/1184251:TCELL_RS03150 ^@ http://purl.uniprot.org/uniprot/I3TE37 ^@ Similarity ^@ Belongs to the archaeal riboflavin kinase family. http://togogenome.org/gene/1184251:TCELL_RS02770 ^@ http://purl.uniprot.org/uniprot/I3TDW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS00385 ^@ http://purl.uniprot.org/uniprot/I3TCL1 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS02610 ^@ http://purl.uniprot.org/uniprot/I3TDT7 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/1184251:TCELL_RS01570 ^@ http://purl.uniprot.org/uniprot/I3TD88 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/1184251:TCELL_RS01175 ^@ http://purl.uniprot.org/uniprot/I3TD11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/1184251:TCELL_RS04265 ^@ http://purl.uniprot.org/uniprot/I3TEQ3 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/1184251:TCELL_RS05565 ^@ http://purl.uniprot.org/uniprot/I3TFG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS04000 ^@ http://purl.uniprot.org/uniprot/I3TEK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS03295 ^@ http://purl.uniprot.org/uniprot/I3TE62 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/1184251:TCELL_RS06060 ^@ http://purl.uniprot.org/uniprot/I3TFR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS04810 ^@ http://purl.uniprot.org/uniprot/I3TF13 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS01690 ^@ http://purl.uniprot.org/uniprot/I3TDB4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1184251:TCELL_RS06770 ^@ http://purl.uniprot.org/uniprot/I3TG54 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS07040 ^@ http://purl.uniprot.org/uniprot/I3TGA8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS05120 ^@ http://purl.uniprot.org/uniprot/I3TF72 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS06405 ^@ http://purl.uniprot.org/uniprot/I3TFY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01795 ^@ http://purl.uniprot.org/uniprot/I3TDD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS06990 ^@ http://purl.uniprot.org/uniprot/I3TG98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS00065 ^@ http://purl.uniprot.org/uniprot/I3TCE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS02765 ^@ http://purl.uniprot.org/uniprot/I3TDW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1184251:TCELL_RS01750 ^@ http://purl.uniprot.org/uniprot/I3TDC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1184251:TCELL_RS05075 ^@ http://purl.uniprot.org/uniprot/I3TF63 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/1184251:TCELL_RS03510 ^@ http://purl.uniprot.org/uniprot/I3TEA4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS02170 ^@ http://purl.uniprot.org/uniprot/I3TDK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS06555 ^@ http://purl.uniprot.org/uniprot/I3TG15 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1184251:TCELL_RS00645 ^@ http://purl.uniprot.org/uniprot/I3TCQ8 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/1184251:TCELL_RS06565 ^@ http://purl.uniprot.org/uniprot/I3TG17 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1184251:TCELL_RS04125 ^@ http://purl.uniprot.org/uniprot/I3TEM6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/1184251:TCELL_RS00835 ^@ http://purl.uniprot.org/uniprot/I3TCU4 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1184251:TCELL_RS02780 ^@ http://purl.uniprot.org/uniprot/I3TDW8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/1184251:TCELL_RS01715 ^@ http://purl.uniprot.org/uniprot/I3TDB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS04390 ^@ http://purl.uniprot.org/uniprot/I3TES8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1184251:TCELL_RS03220 ^@ http://purl.uniprot.org/uniprot/I3TE49 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS05685 ^@ http://purl.uniprot.org/uniprot/I3TFJ2 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1184251:TCELL_RS01315 ^@ http://purl.uniprot.org/uniprot/I3TD38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS05550 ^@ http://purl.uniprot.org/uniprot/I3TFG5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS02000 ^@ http://purl.uniprot.org/uniprot/I3TDH3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1184251:TCELL_RS03230 ^@ http://purl.uniprot.org/uniprot/I3TE51 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS01455 ^@ http://purl.uniprot.org/uniprot/I3TD65 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/1184251:TCELL_RS04165 ^@ http://purl.uniprot.org/uniprot/I3TEN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS06870 ^@ http://purl.uniprot.org/uniprot/I3TG74 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1184251:TCELL_RS04510 ^@ http://purl.uniprot.org/uniprot/I3TEV2 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1184251:TCELL_RS03055 ^@ http://purl.uniprot.org/uniprot/I3TE19 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS02380 ^@ http://purl.uniprot.org/uniprot/I3TDP4 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/1184251:TCELL_RS05475 ^@ http://purl.uniprot.org/uniprot/I3TFF0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1184251:TCELL_RS02565 ^@ http://purl.uniprot.org/uniprot/I3TDS8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/1184251:TCELL_RS04060 ^@ http://purl.uniprot.org/uniprot/I3TEL4 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/1184251:TCELL_RS06470 ^@ http://purl.uniprot.org/uniprot/I3TFZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS00840 ^@ http://purl.uniprot.org/uniprot/I3TCU5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/1184251:TCELL_RS00435 ^@ http://purl.uniprot.org/uniprot/I3TCM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1184251:TCELL_RS07250 ^@ http://purl.uniprot.org/uniprot/I3TGE9 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/1184251:TCELL_RS04855 ^@ http://purl.uniprot.org/uniprot/I3TF22 ^@ Similarity ^@ Belongs to the UPF0252 family. http://togogenome.org/gene/1184251:TCELL_RS04230 ^@ http://purl.uniprot.org/uniprot/I3TEP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02700 ^@ http://purl.uniprot.org/uniprot/I3TDV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1184251:TCELL_RS02810 ^@ http://purl.uniprot.org/uniprot/I3TDX4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS01870 ^@ http://purl.uniprot.org/uniprot/I3TDE9 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/1184251:TCELL_RS06970 ^@ http://purl.uniprot.org/uniprot/I3TG94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS04205 ^@ http://purl.uniprot.org/uniprot/I3TEP2 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1184251:TCELL_RS01445 ^@ http://purl.uniprot.org/uniprot/I3TD63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS06705 ^@ http://purl.uniprot.org/uniprot/I3TG44 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/1184251:TCELL_RS06900 ^@ http://purl.uniprot.org/uniprot/I3TG80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00870 ^@ http://purl.uniprot.org/uniprot/I3TCV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/1184251:TCELL_RS05745 ^@ http://purl.uniprot.org/uniprot/I3TFK4 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1184251:TCELL_RS04605 ^@ http://purl.uniprot.org/uniprot/I3TEX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02120 ^@ http://purl.uniprot.org/uniprot/I3TDJ6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1184251:TCELL_RS06545 ^@ http://purl.uniprot.org/uniprot/I3TG13 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/1184251:TCELL_RS06065 ^@ http://purl.uniprot.org/uniprot/I3TFR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS04225 ^@ http://purl.uniprot.org/uniprot/I3TEP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00720 ^@ http://purl.uniprot.org/uniprot/I3TCS1 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS02800 ^@ http://purl.uniprot.org/uniprot/I3TDX2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1184251:TCELL_RS05850 ^@ http://purl.uniprot.org/uniprot/I3TFM5 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/1184251:TCELL_RS01975 ^@ http://purl.uniprot.org/uniprot/I3TDG8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/1184251:TCELL_RS01790 ^@ http://purl.uniprot.org/uniprot/I3TDD4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS03575 ^@ http://purl.uniprot.org/uniprot/I3TEB7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1184251:TCELL_RS01675 ^@ http://purl.uniprot.org/uniprot/I3TDB1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/1184251:TCELL_RS00310 ^@ http://purl.uniprot.org/uniprot/I3TCJ7 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/1184251:TCELL_RS02655 ^@ http://purl.uniprot.org/uniprot/I3TDU7 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/1184251:TCELL_RS07060 ^@ http://purl.uniprot.org/uniprot/I3TGB2 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/1184251:TCELL_RS02160 ^@ http://purl.uniprot.org/uniprot/I3TDK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/1184251:TCELL_RS06930 ^@ http://purl.uniprot.org/uniprot/I3TG86 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS01920 ^@ http://purl.uniprot.org/uniprot/I3TDF7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS04325 ^@ http://purl.uniprot.org/uniprot/I3TER5 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/1184251:TCELL_RS02350 ^@ http://purl.uniprot.org/uniprot/I3TDN8 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/1184251:TCELL_RS03865 ^@ http://purl.uniprot.org/uniprot/I3TEH5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1184251:TCELL_RS01225 ^@ http://purl.uniprot.org/uniprot/I3TD21 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/1184251:TCELL_RS02410 ^@ http://purl.uniprot.org/uniprot/I3TDP9 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/1184251:TCELL_RS02775 ^@ http://purl.uniprot.org/uniprot/I3TDW7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1184251:TCELL_RS05995 ^@ http://purl.uniprot.org/uniprot/I3TFQ4 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1184251:TCELL_RS06795 ^@ http://purl.uniprot.org/uniprot/I3TG59 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS06440 ^@ http://purl.uniprot.org/uniprot/I3TFZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS03040 ^@ http://purl.uniprot.org/uniprot/I3TE16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/1184251:TCELL_RS01575 ^@ http://purl.uniprot.org/uniprot/I3TD89 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1184251:TCELL_RS02600 ^@ http://purl.uniprot.org/uniprot/I3TDT5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS06325 ^@ http://purl.uniprot.org/uniprot/I3TFX0 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1184251:TCELL_RS00390 ^@ http://purl.uniprot.org/uniprot/I3TCL2 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/1184251:TCELL_RS02870 ^@ http://purl.uniprot.org/uniprot/I3TDY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/1184251:TCELL_RS01065 ^@ http://purl.uniprot.org/uniprot/I3TCZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02720 ^@ http://purl.uniprot.org/uniprot/I3TDV7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/1184251:TCELL_RS05205 ^@ http://purl.uniprot.org/uniprot/I3TF90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02570 ^@ http://purl.uniprot.org/uniprot/I3TDS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/1184251:TCELL_RS02725 ^@ http://purl.uniprot.org/uniprot/I3TDV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/1184251:TCELL_RS00485 ^@ http://purl.uniprot.org/uniprot/I3TCM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS05635 ^@ http://purl.uniprot.org/uniprot/I3TFI2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/1184251:TCELL_RS02140 ^@ http://purl.uniprot.org/uniprot/I3TDK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/1184251:TCELL_RS02030 ^@ http://purl.uniprot.org/uniprot/I3TDH8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1184251:TCELL_RS02895 ^@ http://purl.uniprot.org/uniprot/I3TDZ0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/1184251:TCELL_RS02190 ^@ http://purl.uniprot.org/uniprot/I3TDK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/1184251:TCELL_RS06480 ^@ http://purl.uniprot.org/uniprot/I3TG00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS04645 ^@ http://purl.uniprot.org/uniprot/I3TEY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00775 ^@ http://purl.uniprot.org/uniprot/I3TCT1 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/1184251:TCELL_RS02390 ^@ http://purl.uniprot.org/uniprot/I3TDP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1184251:TCELL_RS04400 ^@ http://purl.uniprot.org/uniprot/I3TET0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS00875 ^@ http://purl.uniprot.org/uniprot/I3TCV3 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1184251:TCELL_RS07350 ^@ http://purl.uniprot.org/uniprot/I3TFU0 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1184251:TCELL_RS02450 ^@ http://purl.uniprot.org/uniprot/I3TDQ6 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/1184251:TCELL_RS06030 ^@ http://purl.uniprot.org/uniprot/I3TFR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02075 ^@ http://purl.uniprot.org/uniprot/I3TDI7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/1184251:TCELL_RS01985 ^@ http://purl.uniprot.org/uniprot/I3TDH0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1184251:TCELL_RS06110 ^@ http://purl.uniprot.org/uniprot/I3TFS7 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. http://togogenome.org/gene/1184251:TCELL_RS00270 ^@ http://purl.uniprot.org/uniprot/I3TCI9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1184251:TCELL_RS04430 ^@ http://purl.uniprot.org/uniprot/I3TET6 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/1184251:TCELL_RS04600 ^@ http://purl.uniprot.org/uniprot/I3TEX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02965 ^@ http://purl.uniprot.org/uniprot/I3TE02 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/1184251:TCELL_RS03215 ^@ http://purl.uniprot.org/uniprot/I3TE48 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS02630 ^@ http://purl.uniprot.org/uniprot/I3TDU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS04045 ^@ http://purl.uniprot.org/uniprot/I3TEL1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1184251:TCELL_RS02005 ^@ http://purl.uniprot.org/uniprot/I3TDH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/1184251:TCELL_RS00690 ^@ http://purl.uniprot.org/uniprot/I3TCR7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS00360 ^@ http://purl.uniprot.org/uniprot/I3TCK7 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/1184251:TCELL_RS05385 ^@ http://purl.uniprot.org/uniprot/I3TFD0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/1184251:TCELL_RS04190 ^@ http://purl.uniprot.org/uniprot/I3TEN9 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/1184251:TCELL_RS01960 ^@ http://purl.uniprot.org/uniprot/I3TDG5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/1184251:TCELL_RS01610 ^@ http://purl.uniprot.org/uniprot/I3TD97 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1184251:TCELL_RS02620 ^@ http://purl.uniprot.org/uniprot/I3TDT9 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1184251:TCELL_RS04420 ^@ http://purl.uniprot.org/uniprot/I3TET4 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. http://togogenome.org/gene/1184251:TCELL_RS06275 ^@ http://purl.uniprot.org/uniprot/I3TFW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS06630 ^@ http://purl.uniprot.org/uniprot/I3TG30 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1184251:TCELL_RS00350 ^@ http://purl.uniprot.org/uniprot/I3TCK5 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/1184251:TCELL_RS03240 ^@ http://purl.uniprot.org/uniprot/I3TE53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS05215 ^@ http://purl.uniprot.org/uniprot/I3TF92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS02685 ^@ http://purl.uniprot.org/uniprot/I3TDV1 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/1184251:TCELL_RS05195 ^@ http://purl.uniprot.org/uniprot/I3TF88 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/1184251:TCELL_RS02615 ^@ http://purl.uniprot.org/uniprot/I3TDT8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/1184251:TCELL_RS01745 ^@ http://purl.uniprot.org/uniprot/I3TDC5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/1184251:TCELL_RS02150 ^@ http://purl.uniprot.org/uniprot/I3TDK2 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/1184251:TCELL_RS01915 ^@ http://purl.uniprot.org/uniprot/I3TDF6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS07205 ^@ http://purl.uniprot.org/uniprot/I3TGE0 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1184251:TCELL_RS02155 ^@ http://purl.uniprot.org/uniprot/I3TDK3 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/1184251:TCELL_RS07045 ^@ http://purl.uniprot.org/uniprot/I3TGA9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1184251:TCELL_RS00440 ^@ http://purl.uniprot.org/uniprot/I3TCM1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1184251:TCELL_RS02560 ^@ http://purl.uniprot.org/uniprot/I3TDS7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1184251:TCELL_RS06175 ^@ http://purl.uniprot.org/uniprot/I3TFU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS06575 ^@ http://purl.uniprot.org/uniprot/I3TG19 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/1184251:TCELL_RS05290 ^@ http://purl.uniprot.org/uniprot/I3TFA8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS01780 ^@ http://purl.uniprot.org/uniprot/I3TDD2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1184251:TCELL_RS04980 ^@ http://purl.uniprot.org/uniprot/I3TF44 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1184251:TCELL_RS06985 ^@ http://purl.uniprot.org/uniprot/I3TG97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/1184251:TCELL_RS01055 ^@ http://purl.uniprot.org/uniprot/I3TCY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS01685 ^@ http://purl.uniprot.org/uniprot/I3TDB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/1184251:TCELL_RS03525 ^@ http://purl.uniprot.org/uniprot/I3TEA7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS04015 ^@ http://purl.uniprot.org/uniprot/I3TEK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00395 ^@ http://purl.uniprot.org/uniprot/I3TCL3 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/1184251:TCELL_RS03720 ^@ http://purl.uniprot.org/uniprot/I3TEE5 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/1184251:TCELL_RS03770 ^@ http://purl.uniprot.org/uniprot/I3TEF5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1184251:TCELL_RS00235 ^@ http://purl.uniprot.org/uniprot/I3TCI2 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/1184251:TCELL_RS05870 ^@ http://purl.uniprot.org/uniprot/I3TFM9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/1184251:TCELL_RS03420 ^@ http://purl.uniprot.org/uniprot/I3TE86 ^@ Domain|||Function|||Similarity ^@ Belongs to the Nre family.|||Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.|||Involved in DNA damage repair. http://togogenome.org/gene/1184251:TCELL_RS04895 ^@ http://purl.uniprot.org/uniprot/I3TF30 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1184251:TCELL_RS02360 ^@ http://purl.uniprot.org/uniprot/I3TDP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/1184251:TCELL_RS01495 ^@ http://purl.uniprot.org/uniprot/I3TD73 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/1184251:TCELL_RS00170 ^@ http://purl.uniprot.org/uniprot/I3TCG9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1184251:TCELL_RS01510 ^@ http://purl.uniprot.org/uniprot/I3TD76 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1184251:TCELL_RS02370 ^@ http://purl.uniprot.org/uniprot/I3TDP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1184251:TCELL_RS00160 ^@ http://purl.uniprot.org/uniprot/I3TCG7 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1184251:TCELL_RS01775 ^@ http://purl.uniprot.org/uniprot/I3TDD1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS01965 ^@ http://purl.uniprot.org/uniprot/I3TDG6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Belongs to the ribosomal protein L31e family. http://togogenome.org/gene/1184251:TCELL_RS04985 ^@ http://purl.uniprot.org/uniprot/I3TF45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/1184251:TCELL_RS01950 ^@ http://purl.uniprot.org/uniprot/I3TDG3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS00135 ^@ http://purl.uniprot.org/uniprot/I3TCG2 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/1184251:TCELL_RS03855 ^@ http://purl.uniprot.org/uniprot/I3TEH3 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/1184251:TCELL_RS01535 ^@ http://purl.uniprot.org/uniprot/I3TD81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1184251:TCELL_RS02010 ^@ http://purl.uniprot.org/uniprot/I3TDH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/1184251:TCELL_RS02530 ^@ http://purl.uniprot.org/uniprot/I3TDS2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS01725 ^@ http://purl.uniprot.org/uniprot/I3TDC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1184251:TCELL_RS04715 ^@ http://purl.uniprot.org/uniprot/I3TEZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01095 ^@ http://purl.uniprot.org/uniprot/I3TCZ6 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1184251:TCELL_RS02785 ^@ http://purl.uniprot.org/uniprot/I3TDW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1184251:TCELL_RS06625 ^@ http://purl.uniprot.org/uniprot/I3TG29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS07100 ^@ http://purl.uniprot.org/uniprot/I3TGC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS05360 ^@ http://purl.uniprot.org/uniprot/I3TFC4 ^@ Function ^@ Catalyzes the synthesis of GMP from XMP. http://togogenome.org/gene/1184251:TCELL_RS01970 ^@ http://purl.uniprot.org/uniprot/I3TDG7 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/1184251:TCELL_RS03790 ^@ http://purl.uniprot.org/uniprot/I3TEF9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1184251:TCELL_RS00295 ^@ http://purl.uniprot.org/uniprot/I3TCJ4 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/1184251:TCELL_RS05500 ^@ http://purl.uniprot.org/uniprot/I3TFF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS03250 ^@ http://purl.uniprot.org/uniprot/I3TE54 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/1184251:TCELL_RS05450 ^@ http://purl.uniprot.org/uniprot/I3TFE3 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1184251:TCELL_RS03890 ^@ http://purl.uniprot.org/uniprot/I3TEI0 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/1184251:TCELL_RS07230 ^@ http://purl.uniprot.org/uniprot/I3TGE5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS05445 ^@ http://purl.uniprot.org/uniprot/I3TFE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS00230 ^@ http://purl.uniprot.org/uniprot/I3TCI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1184251:TCELL_RS04900 ^@ http://purl.uniprot.org/uniprot/I3TF31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01325 ^@ http://purl.uniprot.org/uniprot/I3TD40 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/1184251:TCELL_RS01440 ^@ http://purl.uniprot.org/uniprot/I3TD62 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/1184251:TCELL_RS04295 ^@ http://purl.uniprot.org/uniprot/I3TEQ9 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/1184251:TCELL_RS04615 ^@ http://purl.uniprot.org/uniprot/I3TEX4 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1184251:TCELL_RS02950 ^@ http://purl.uniprot.org/uniprot/I3TDZ9 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/1184251:TCELL_RS05690 ^@ http://purl.uniprot.org/uniprot/I3TFJ3 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/1184251:TCELL_RS06445 ^@ http://purl.uniprot.org/uniprot/I3TFZ3 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1184251:TCELL_RS05460 ^@ http://purl.uniprot.org/uniprot/I3TFE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02955 ^@ http://purl.uniprot.org/uniprot/I3TE00 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1184251:TCELL_RS00320 ^@ http://purl.uniprot.org/uniprot/I3TCJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/1184251:TCELL_RS05680 ^@ http://purl.uniprot.org/uniprot/I3TFJ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/1184251:TCELL_RS04875 ^@ http://purl.uniprot.org/uniprot/I3TF26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS04555 ^@ http://purl.uniprot.org/uniprot/I3TEW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS07340 ^@ http://purl.uniprot.org/uniprot/I3TFL3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1184251:TCELL_RS04020 ^@ http://purl.uniprot.org/uniprot/I3TEK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01380 ^@ http://purl.uniprot.org/uniprot/I3TD51 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/1184251:TCELL_RS04440 ^@ http://purl.uniprot.org/uniprot/I3TET8 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1184251:TCELL_RS03715 ^@ http://purl.uniprot.org/uniprot/I3TEE4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS00280 ^@ http://purl.uniprot.org/uniprot/I3TCJ1 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/1184251:TCELL_RS02940 ^@ http://purl.uniprot.org/uniprot/I3TDZ7 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/1184251:TCELL_RS02660 ^@ http://purl.uniprot.org/uniprot/I3TDU8 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/1184251:TCELL_RS01470 ^@ http://purl.uniprot.org/uniprot/I3TD68 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS05440 ^@ http://purl.uniprot.org/uniprot/I3TFE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS00300 ^@ http://purl.uniprot.org/uniprot/I3TCJ5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/1184251:TCELL_RS07030 ^@ http://purl.uniprot.org/uniprot/I3TGA6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS02840 ^@ http://purl.uniprot.org/uniprot/I3TDX9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/1184251:TCELL_RS00830 ^@ http://purl.uniprot.org/uniprot/I3TCU2 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/1184251:TCELL_RS05990 ^@ http://purl.uniprot.org/uniprot/I3TFQ3 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1184251:TCELL_RS05530 ^@ http://purl.uniprot.org/uniprot/I3TFG1 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/1184251:TCELL_RS00095 ^@ http://purl.uniprot.org/uniprot/I3TCF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS04105 ^@ http://purl.uniprot.org/uniprot/I3TEM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00130 ^@ http://purl.uniprot.org/uniprot/I3TCG1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/1184251:TCELL_RS04385 ^@ http://purl.uniprot.org/uniprot/I3TES7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS04890 ^@ http://purl.uniprot.org/uniprot/I3TF29 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1184251:TCELL_RS00450 ^@ http://purl.uniprot.org/uniprot/I3TCM3 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1184251:TCELL_RS00400 ^@ http://purl.uniprot.org/uniprot/I3TCL4 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/1184251:TCELL_RS03165 ^@ http://purl.uniprot.org/uniprot/I3TE40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02790 ^@ http://purl.uniprot.org/uniprot/I3TDX0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1184251:TCELL_RS02095 ^@ http://purl.uniprot.org/uniprot/I3TDJ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/1184251:TCELL_RS03805 ^@ http://purl.uniprot.org/uniprot/I3TEG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1184251:TCELL_RS00550 ^@ http://purl.uniprot.org/uniprot/I3TCN8 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1184251:TCELL_RS01405 ^@ http://purl.uniprot.org/uniprot/I3TD56 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1184251:TCELL_RS02230 ^@ http://purl.uniprot.org/uniprot/I3TDL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS06495 ^@ http://purl.uniprot.org/uniprot/I3TG03 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS02885 ^@ http://purl.uniprot.org/uniprot/I3TDY8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/1184251:TCELL_RS03225 ^@ http://purl.uniprot.org/uniprot/I3TE50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS02835 ^@ http://purl.uniprot.org/uniprot/I3TDX8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/1184251:TCELL_RS05005 ^@ http://purl.uniprot.org/uniprot/I3TF49 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS01365 ^@ http://purl.uniprot.org/uniprot/I3TD49 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1184251:TCELL_RS02020 ^@ http://purl.uniprot.org/uniprot/I3TDH7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS05535 ^@ http://purl.uniprot.org/uniprot/I3TFG2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1184251:TCELL_RS00325 ^@ http://purl.uniprot.org/uniprot/I3TCK0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS04515 ^@ http://purl.uniprot.org/uniprot/I3TEV3 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/1184251:TCELL_RS02730 ^@ http://purl.uniprot.org/uniprot/I3TDV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/1184251:TCELL_RS01130 ^@ http://purl.uniprot.org/uniprot/I3TD03 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1184251:TCELL_RS01490 ^@ http://purl.uniprot.org/uniprot/I3TD72 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1184251:TCELL_RS01630 ^@ http://purl.uniprot.org/uniprot/I3TDA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1184251:TCELL_RS06550 ^@ http://purl.uniprot.org/uniprot/I3TG14 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/1184251:TCELL_RS00825 ^@ http://purl.uniprot.org/uniprot/I3TCU1 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/1184251:TCELL_RS03145 ^@ http://purl.uniprot.org/uniprot/I3TE36 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1184251:TCELL_RS00695 ^@ http://purl.uniprot.org/uniprot/I3TCR8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1184251:TCELL_RS03395 ^@ http://purl.uniprot.org/uniprot/I3TE81 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1184251:TCELL_RS05405 ^@ http://purl.uniprot.org/uniprot/I3TFD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1184251:TCELL_RS04175 ^@ http://purl.uniprot.org/uniprot/I3TEN6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1184251:TCELL_RS02055 ^@ http://purl.uniprot.org/uniprot/I3TDI3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/1184251:TCELL_RS05800 ^@ http://purl.uniprot.org/uniprot/I3TFL5 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/1184251:TCELL_RS02555 ^@ http://purl.uniprot.org/uniprot/I3TDS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/1184251:TCELL_RS05675 ^@ http://purl.uniprot.org/uniprot/I3TFJ0 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/1184251:TCELL_RS06365 ^@ http://purl.uniprot.org/uniprot/I3TFX7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/1184251:TCELL_RS06180 ^@ http://purl.uniprot.org/uniprot/I3TFU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS02195 ^@ http://purl.uniprot.org/uniprot/I3TDK9 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1184251:TCELL_RS02690 ^@ http://purl.uniprot.org/uniprot/I3TDV2 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1184251:TCELL_RS04360 ^@ http://purl.uniprot.org/uniprot/I3TES2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/1184251:TCELL_RS00330 ^@ http://purl.uniprot.org/uniprot/I3TCK1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS04460 ^@ http://purl.uniprot.org/uniprot/I3TEU2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1184251:TCELL_RS06295 ^@ http://purl.uniprot.org/uniprot/I3TFW4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS02900 ^@ http://purl.uniprot.org/uniprot/I3TDZ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/1184251:TCELL_RS04945 ^@ http://purl.uniprot.org/uniprot/I3TF36 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1184251:TCELL_RS00285 ^@ http://purl.uniprot.org/uniprot/I3TCJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/1184251:TCELL_RS04970 ^@ http://purl.uniprot.org/uniprot/I3TF42 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1184251:TCELL_RS02050 ^@ http://purl.uniprot.org/uniprot/I3TDI2 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/1184251:TCELL_RS01560 ^@ http://purl.uniprot.org/uniprot/I3TD86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1184251:TCELL_RS01530 ^@ http://purl.uniprot.org/uniprot/I3TD80 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1184251:TCELL_RS02415 ^@ http://purl.uniprot.org/uniprot/I3TDQ0 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/1184251:TCELL_RS02875 ^@ http://purl.uniprot.org/uniprot/I3TDY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/1184251:TCELL_RS05785 ^@ http://purl.uniprot.org/uniprot/I3TFL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00265 ^@ http://purl.uniprot.org/uniprot/I3TCI8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1184251:TCELL_RS04965 ^@ http://purl.uniprot.org/uniprot/I3TF41 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/1184251:TCELL_RS02945 ^@ http://purl.uniprot.org/uniprot/I3TDZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1184251:TCELL_RS05570 ^@ http://purl.uniprot.org/uniprot/I3TFG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS05125 ^@ http://purl.uniprot.org/uniprot/I3TF73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01555 ^@ http://purl.uniprot.org/uniprot/I3TD85 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/1184251:TCELL_RS04660 ^@ http://purl.uniprot.org/uniprot/I3TEY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00665 ^@ http://purl.uniprot.org/uniprot/I3TCR2 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/1184251:TCELL_RS07285 ^@ http://purl.uniprot.org/uniprot/I3TD25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01120 ^@ http://purl.uniprot.org/uniprot/I3TD01 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1184251:TCELL_RS00100 ^@ http://purl.uniprot.org/uniprot/I3TCF5 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/1184251:TCELL_RS01875 ^@ http://purl.uniprot.org/uniprot/I3TDF0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/1184251:TCELL_RS03610 ^@ http://purl.uniprot.org/uniprot/I3TEC4 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1184251:TCELL_RS00370 ^@ http://purl.uniprot.org/uniprot/I3TCK9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/1184251:TCELL_RS06120 ^@ http://purl.uniprot.org/uniprot/I3TFS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS03835 ^@ http://purl.uniprot.org/uniprot/I3TEG9 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1184251:TCELL_RS02345 ^@ http://purl.uniprot.org/uniprot/I3TDN7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/1184251:TCELL_RS06025 ^@ http://purl.uniprot.org/uniprot/I3TFR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS05105 ^@ http://purl.uniprot.org/uniprot/I3TF69 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS01600 ^@ http://purl.uniprot.org/uniprot/I3TD95 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1184251:TCELL_RS07360 ^@ http://purl.uniprot.org/uniprot/I3TFY7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS00750 ^@ http://purl.uniprot.org/uniprot/I3TCS6 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/1184251:TCELL_RS06310 ^@ http://purl.uniprot.org/uniprot/I3TFW7 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1184251:TCELL_RS07105 ^@ http://purl.uniprot.org/uniprot/I3TGC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS01955 ^@ http://purl.uniprot.org/uniprot/I3TDG4 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/1184251:TCELL_RS03160 ^@ http://purl.uniprot.org/uniprot/I3TE39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01835 ^@ http://purl.uniprot.org/uniprot/I3TDE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.|||The system is composed of three essential subunits: KdpA, KdpB and KdpC. http://togogenome.org/gene/1184251:TCELL_RS01890 ^@ http://purl.uniprot.org/uniprot/I3TDF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS01995 ^@ http://purl.uniprot.org/uniprot/I3TDH2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/1184251:TCELL_RS00755 ^@ http://purl.uniprot.org/uniprot/I3TCS7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1184251:TCELL_RS03465 ^@ http://purl.uniprot.org/uniprot/I3TE95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/1184251:TCELL_RS06840 ^@ http://purl.uniprot.org/uniprot/I3TG68 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1184251:TCELL_RS01125 ^@ http://purl.uniprot.org/uniprot/I3TD02 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1184251:TCELL_RS05725 ^@ http://purl.uniprot.org/uniprot/I3TFK0 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer composed of an alpha and a beta subunit.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/1184251:TCELL_RS03875 ^@ http://purl.uniprot.org/uniprot/I3TEH7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1184251:TCELL_RS02855 ^@ http://purl.uniprot.org/uniprot/I3TDY2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/1184251:TCELL_RS03375 ^@ http://purl.uniprot.org/uniprot/I3TE77 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/1184251:TCELL_RS03930 ^@ http://purl.uniprot.org/uniprot/I3TEI8 ^@ Similarity ^@ Belongs to the isopentenyl phosphate kinase family. http://togogenome.org/gene/1184251:TCELL_RS05485 ^@ http://purl.uniprot.org/uniprot/I3TFF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1184251:TCELL_RS05605 ^@ http://purl.uniprot.org/uniprot/I3TFH6 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1184251:TCELL_RS02745 ^@ http://purl.uniprot.org/uniprot/I3TDW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1184251:TCELL_RS07160 ^@ http://purl.uniprot.org/uniprot/I3TGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1184251:TCELL_RS06305 ^@ http://purl.uniprot.org/uniprot/I3TFW6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1184251:TCELL_RS04940 ^@ http://purl.uniprot.org/uniprot/I3TF35 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS06595 ^@ http://purl.uniprot.org/uniprot/I3TG23 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1184251:TCELL_RS06400 ^@ http://purl.uniprot.org/uniprot/I3TFY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1184251:TCELL_RS05480 ^@ http://purl.uniprot.org/uniprot/I3TFF1 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS01895 ^@ http://purl.uniprot.org/uniprot/I3TDF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/1184251:TCELL_RS05020 ^@ http://purl.uniprot.org/uniprot/I3TF51 ^@ Subcellular Location Annotation ^@ Encapsulin nanocompartment http://togogenome.org/gene/1184251:TCELL_RS00810 ^@ http://purl.uniprot.org/uniprot/I3TCT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/1184251:TCELL_RS03205 ^@ http://purl.uniprot.org/uniprot/I3TE46 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS06520 ^@ http://purl.uniprot.org/uniprot/I3TG08 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS05115 ^@ http://purl.uniprot.org/uniprot/I3TF71 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1184251:TCELL_RS01205 ^@ http://purl.uniprot.org/uniprot/I3TD17 ^@ Caution|||Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS04180 ^@ http://purl.uniprot.org/uniprot/I3TEN7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1184251:TCELL_RS03130 ^@ http://purl.uniprot.org/uniprot/I3TE34 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/1184251:TCELL_RS04990 ^@ http://purl.uniprot.org/uniprot/I3TF46 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1184251:TCELL_RS06655 ^@ http://purl.uniprot.org/uniprot/I3TG34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1184251:TCELL_RS00745 ^@ http://purl.uniprot.org/uniprot/I3TCS5 ^@ Caution|||Function|||Similarity ^@ Belongs to the TFIIB family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/1184251:TCELL_RS03195 ^@ http://purl.uniprot.org/uniprot/I3TE44 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/1184251:TCELL_RS00620 ^@ http://purl.uniprot.org/uniprot/I3TCQ2 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/1184251:TCELL_RS03600 ^@ http://purl.uniprot.org/uniprot/I3TEC2 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/1184251:TCELL_RS05825 ^@ http://purl.uniprot.org/uniprot/I3TFM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/1184251:TCELL_RS04975 ^@ http://purl.uniprot.org/uniprot/I3TF43 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1184251:TCELL_RS01740 ^@ http://purl.uniprot.org/uniprot/I3TDC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1184251:TCELL_RS03355 ^@ http://purl.uniprot.org/uniprot/I3TE73 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/1184251:TCELL_RS01480 ^@ http://purl.uniprot.org/uniprot/I3TD70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1184251:TCELL_RS01180 ^@ http://purl.uniprot.org/uniprot/I3TD12 ^@ Similarity ^@ Belongs to the peptidase S8 family.