http://togogenome.org/gene/1006006:MCUP_RS07785 ^@ http://purl.uniprot.org/uniprot/F4FZZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS00815 ^@ http://purl.uniprot.org/uniprot/F4FYE8 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/1006006:MCUP_RS00180 ^@ http://purl.uniprot.org/uniprot/F4FXU7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1006006:MCUP_RS02985 ^@ http://purl.uniprot.org/uniprot/F4G0Z8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/1006006:MCUP_RS02475 ^@ http://purl.uniprot.org/uniprot/F4G093 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/1006006:MCUP_RS07625 ^@ http://purl.uniprot.org/uniprot/F4FZW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS09215 ^@ http://purl.uniprot.org/uniprot/F4G1N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS00035 ^@ http://purl.uniprot.org/uniprot/F4G3C0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/1006006:MCUP_RS05260 ^@ http://purl.uniprot.org/uniprot/F4G309 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/1006006:MCUP_RS01225 ^@ http://purl.uniprot.org/uniprot/F4FYV8 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/1006006:MCUP_RS06740 ^@ http://purl.uniprot.org/uniprot/F4FYP1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1006006:MCUP_RS03995 ^@ http://purl.uniprot.org/uniprot/F4G203 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS01995 ^@ http://purl.uniprot.org/uniprot/F4FZR8 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/1006006:MCUP_RS09305 ^@ http://purl.uniprot.org/uniprot/F4G1Q7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1006006:MCUP_RS07730 ^@ http://purl.uniprot.org/uniprot/F4FZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1006006:MCUP_RS09290 ^@ http://purl.uniprot.org/uniprot/F4G1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1006006:MCUP_RS04795 ^@ http://purl.uniprot.org/uniprot/F4G2L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1006006:MCUP_RS00740 ^@ http://purl.uniprot.org/uniprot/F4FYD5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/1006006:MCUP_RS02955 ^@ http://purl.uniprot.org/uniprot/F4G0Z2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1006006:MCUP_RS03065 ^@ http://purl.uniprot.org/uniprot/F4G113 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1006006:MCUP_RS05885 ^@ http://purl.uniprot.org/uniprot/F4G3I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/1006006:MCUP_RS01410 ^@ http://purl.uniprot.org/uniprot/F4FZ75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1006006:MCUP_RS00440 ^@ http://purl.uniprot.org/uniprot/F4FXZ6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/1006006:MCUP_RS01240 ^@ http://purl.uniprot.org/uniprot/F4FYW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/1006006:MCUP_RS00700 ^@ http://purl.uniprot.org/uniprot/F4FYC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS04345 ^@ http://purl.uniprot.org/uniprot/F4G2B8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS08805 ^@ http://purl.uniprot.org/uniprot/F4G182 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/1006006:MCUP_RS06815 ^@ http://purl.uniprot.org/uniprot/F4FYY5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1006006:MCUP_RS04160 ^@ http://purl.uniprot.org/uniprot/F4G280 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1006006:MCUP_RS02750 ^@ http://purl.uniprot.org/uniprot/F4G0M6 ^@ Function|||Similarity ^@ Belongs to the TrpA family.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1006006:MCUP_RS00315 ^@ http://purl.uniprot.org/uniprot/F4FXX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/1006006:MCUP_RS00655 ^@ http://purl.uniprot.org/uniprot/F4FYB8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS00330 ^@ http://purl.uniprot.org/uniprot/F4FXX4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS03215 ^@ http://purl.uniprot.org/uniprot/F4G143 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS09360 ^@ http://purl.uniprot.org/uniprot/F4G1R8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1006006:MCUP_RS00185 ^@ http://purl.uniprot.org/uniprot/F4FXU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1006006:MCUP_RS05255 ^@ http://purl.uniprot.org/uniprot/F4G2Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NiCoT transporter (TC 2.A.52) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1006006:MCUP_RS08645 ^@ http://purl.uniprot.org/uniprot/F4G0X7 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/1006006:MCUP_RS00285 ^@ http://purl.uniprot.org/uniprot/F4FXW7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/1006006:MCUP_RS08840 ^@ http://purl.uniprot.org/uniprot/F4G189 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/1006006:MCUP_RS04205 ^@ http://purl.uniprot.org/uniprot/F4G289 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1006006:MCUP_RS00790 ^@ http://purl.uniprot.org/uniprot/F4FYE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS06010 ^@ http://purl.uniprot.org/uniprot/F4G3L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS03500 ^@ http://purl.uniprot.org/uniprot/F4G1H2 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1006006:MCUP_RS08165 ^@ http://purl.uniprot.org/uniprot/F4G0E6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/1006006:MCUP_RS05105 ^@ http://purl.uniprot.org/uniprot/F4G2U5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS03610 ^@ http://purl.uniprot.org/uniprot/F4G1K2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS09550 ^@ http://purl.uniprot.org/uniprot/F4G229 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1006006:MCUP_RS00190 ^@ http://purl.uniprot.org/uniprot/F4FXU9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/1006006:MCUP_RS09280 ^@ http://purl.uniprot.org/uniprot/F4G1Q2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/1006006:MCUP_RS02590 ^@ http://purl.uniprot.org/uniprot/F4G0J6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1006006:MCUP_RS01845 ^@ http://purl.uniprot.org/uniprot/F4FZN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/1006006:MCUP_RS01860 ^@ http://purl.uniprot.org/uniprot/F4FZP2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS05670 ^@ http://purl.uniprot.org/uniprot/F4G3E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 13 family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS09330 ^@ http://purl.uniprot.org/uniprot/F4G1R2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/1006006:MCUP_RS09695 ^@ http://purl.uniprot.org/uniprot/F4G258 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/1006006:MCUP_RS02430 ^@ http://purl.uniprot.org/uniprot/F4G084 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/1006006:MCUP_RS09235 ^@ http://purl.uniprot.org/uniprot/F4G1P2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1006006:MCUP_RS07470 ^@ http://purl.uniprot.org/uniprot/F4FZK1 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1006006:MCUP_RS05685 ^@ http://purl.uniprot.org/uniprot/F4G3E8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/1006006:MCUP_RS09540 ^@ http://purl.uniprot.org/uniprot/F4G228 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1006006:MCUP_RS04630 ^@ http://purl.uniprot.org/uniprot/F4G2H9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS04870 ^@ http://purl.uniprot.org/uniprot/F4G2N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS09455 ^@ http://purl.uniprot.org/uniprot/F4G1T5 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/1006006:MCUP_RS09560 ^@ http://purl.uniprot.org/uniprot/F4G231 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/1006006:MCUP_RS02885 ^@ http://purl.uniprot.org/uniprot/F4G0Q4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1006006:MCUP_RS09480 ^@ http://purl.uniprot.org/uniprot/F4G1U0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/1006006:MCUP_RS00780 ^@ http://purl.uniprot.org/uniprot/F4FYE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/1006006:MCUP_RS02265 ^@ http://purl.uniprot.org/uniprot/F4G051 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/1006006:MCUP_RS00730 ^@ http://purl.uniprot.org/uniprot/F4FYD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS09660 ^@ http://purl.uniprot.org/uniprot/F4G251 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/1006006:MCUP_RS00990 ^@ http://purl.uniprot.org/uniprot/F4FYR4 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/1006006:MCUP_RS03410 ^@ http://purl.uniprot.org/uniprot/F4G1F4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1006006:MCUP_RS02855 ^@ http://purl.uniprot.org/uniprot/F4G0P8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1006006:MCUP_RS00200 ^@ http://purl.uniprot.org/uniprot/F4FXV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/1006006:MCUP_RS00375 ^@ http://purl.uniprot.org/uniprot/F4FXY3 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1006006:MCUP_RS06865 ^@ http://purl.uniprot.org/uniprot/F4FYZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS07565 ^@ http://purl.uniprot.org/uniprot/F4FZV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS03380 ^@ http://purl.uniprot.org/uniprot/F4G1E8 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/1006006:MCUP_RS01510 ^@ http://purl.uniprot.org/uniprot/F4FZ94 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/1006006:MCUP_RS07075 ^@ http://purl.uniprot.org/uniprot/F4FZ40 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/1006006:MCUP_RS09375 ^@ http://purl.uniprot.org/uniprot/F4G1S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/1006006:MCUP_RS07130 ^@ http://purl.uniprot.org/uniprot/F4FZ50 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/1006006:MCUP_RS09495 ^@ http://purl.uniprot.org/uniprot/F4G1U1 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/1006006:MCUP_RS07675 ^@ http://purl.uniprot.org/uniprot/F4FZX3 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/1006006:MCUP_RS03095 ^@ http://purl.uniprot.org/uniprot/F4G119 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/1006006:MCUP_RS09390 ^@ http://purl.uniprot.org/uniprot/F4G1S3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS02000 ^@ http://purl.uniprot.org/uniprot/F4FZR9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/1006006:MCUP_RS03645 ^@ http://purl.uniprot.org/uniprot/F4G1K9 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1006006:MCUP_RS01285 ^@ http://purl.uniprot.org/uniprot/F4FYX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1006006:MCUP_RS07460 ^@ http://purl.uniprot.org/uniprot/F4FZJ9 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS02880 ^@ http://purl.uniprot.org/uniprot/F4G0Q3 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/1006006:MCUP_RS04385 ^@ http://purl.uniprot.org/uniprot/F4G2C6 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/1006006:MCUP_RS02990 ^@ http://purl.uniprot.org/uniprot/F4G0Z9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.|||Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity. http://togogenome.org/gene/1006006:MCUP_RS02820 ^@ http://purl.uniprot.org/uniprot/F4G0P1 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS00640 ^@ http://purl.uniprot.org/uniprot/F4FYB7 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. http://togogenome.org/gene/1006006:MCUP_RS06270 ^@ http://purl.uniprot.org/uniprot/F4FY70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS08055 ^@ http://purl.uniprot.org/uniprot/F4G0C4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS01735 ^@ http://purl.uniprot.org/uniprot/F4FZD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1006006:MCUP_RS09200 ^@ http://purl.uniprot.org/uniprot/F4G1N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS03085 ^@ http://purl.uniprot.org/uniprot/F4G117 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/1006006:MCUP_RS01520 ^@ http://purl.uniprot.org/uniprot/F4FZ96 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1006006:MCUP_RS03060 ^@ http://purl.uniprot.org/uniprot/F4G112 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/1006006:MCUP_RS01280 ^@ http://purl.uniprot.org/uniprot/F4FYW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1006006:MCUP_RS00230 ^@ http://purl.uniprot.org/uniprot/F4FXV6 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/1006006:MCUP_RS02875 ^@ http://purl.uniprot.org/uniprot/F4G0Q2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/1006006:MCUP_RS03100 ^@ http://purl.uniprot.org/uniprot/F4G120 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS09025 ^@ http://purl.uniprot.org/uniprot/F4G1C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS08535 ^@ http://purl.uniprot.org/uniprot/F4G0V3 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1006006:MCUP_RS05015 ^@ http://purl.uniprot.org/uniprot/F4G2S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS00840 ^@ http://purl.uniprot.org/uniprot/F4FYF2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/1006006:MCUP_RS09125 ^@ http://purl.uniprot.org/uniprot/F4G1M3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS02685 ^@ http://purl.uniprot.org/uniprot/F4G0L3 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS00735 ^@ http://purl.uniprot.org/uniprot/F4FYD4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1006006:MCUP_RS08475 ^@ http://purl.uniprot.org/uniprot/F4G0T9 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/1006006:MCUP_RS01640 ^@ http://purl.uniprot.org/uniprot/F4FZB8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS09225 ^@ http://purl.uniprot.org/uniprot/F4G1P0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS03965 ^@ http://purl.uniprot.org/uniprot/F4G1Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS02075 ^@ http://purl.uniprot.org/uniprot/F4FZT3 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS09245 ^@ http://purl.uniprot.org/uniprot/F4G1P4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS02835 ^@ http://purl.uniprot.org/uniprot/F4G0P4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/1006006:MCUP_RS09000 ^@ http://purl.uniprot.org/uniprot/F4G1B9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/1006006:MCUP_RS05965 ^@ http://purl.uniprot.org/uniprot/F4G3K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/1006006:MCUP_RS03640 ^@ http://purl.uniprot.org/uniprot/F4G1K8 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1006006:MCUP_RS08835 ^@ http://purl.uniprot.org/uniprot/F4G188 ^@ Function ^@ Catalyzes the synthesis of GMP from XMP. http://togogenome.org/gene/1006006:MCUP_RS08250 ^@ http://purl.uniprot.org/uniprot/F4G0G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS04815 ^@ http://purl.uniprot.org/uniprot/F4G2M2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS07980 ^@ http://purl.uniprot.org/uniprot/F4G0A9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1006006:MCUP_RS00775 ^@ http://purl.uniprot.org/uniprot/F4FYE2 ^@ Similarity ^@ Belongs to the isopentenyl phosphate kinase family. http://togogenome.org/gene/1006006:MCUP_RS02285 ^@ http://purl.uniprot.org/uniprot/F4G055 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/1006006:MCUP_RS09270 ^@ http://purl.uniprot.org/uniprot/F4G1Q0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/1006006:MCUP_RS03050 ^@ http://purl.uniprot.org/uniprot/F4G110 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1006006:MCUP_RS00605 ^@ http://purl.uniprot.org/uniprot/F4FYA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS01895 ^@ http://purl.uniprot.org/uniprot/F4FZP9 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/1006006:MCUP_RS01965 ^@ http://purl.uniprot.org/uniprot/F4FZR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS06745 ^@ http://purl.uniprot.org/uniprot/F4FYP2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1006006:MCUP_RS08940 ^@ http://purl.uniprot.org/uniprot/F4G1B0 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1006006:MCUP_RS07640 ^@ http://purl.uniprot.org/uniprot/F4FZW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS09080 ^@ http://purl.uniprot.org/uniprot/F4G1D5 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/1006006:MCUP_RS06320 ^@ http://purl.uniprot.org/uniprot/F4FY82 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1006006:MCUP_RS02965 ^@ http://purl.uniprot.org/uniprot/F4G0Z4 ^@ Similarity ^@ Belongs to the SHMT family. http://togogenome.org/gene/1006006:MCUP_RS02420 ^@ http://purl.uniprot.org/uniprot/F4G082 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1006006:MCUP_RS05455 ^@ http://purl.uniprot.org/uniprot/F4G370 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1006006:MCUP_RS01255 ^@ http://purl.uniprot.org/uniprot/F4FYW4 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/1006006:MCUP_RS07805 ^@ http://purl.uniprot.org/uniprot/F4FZZ9 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/1006006:MCUP_RS02295 ^@ http://purl.uniprot.org/uniprot/F4G057 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/1006006:MCUP_RS02065 ^@ http://purl.uniprot.org/uniprot/F4FZT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS08555 ^@ http://purl.uniprot.org/uniprot/F4G0V8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS01405 ^@ http://purl.uniprot.org/uniprot/F4FZ74 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/1006006:MCUP_RS08395 ^@ http://purl.uniprot.org/uniprot/F4G0S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS07190 ^@ http://purl.uniprot.org/uniprot/F4FZE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS07175 ^@ http://purl.uniprot.org/uniprot/F4FZ59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1006006:MCUP_RS09635 ^@ http://purl.uniprot.org/uniprot/F4G246 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/1006006:MCUP_RS00755 ^@ http://purl.uniprot.org/uniprot/F4FYD8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1006006:MCUP_RS07055 ^@ http://purl.uniprot.org/uniprot/F4FZ36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS01875 ^@ http://purl.uniprot.org/uniprot/F4FZP5 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1006006:MCUP_RS01725 ^@ http://purl.uniprot.org/uniprot/F4FZD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02490 ^@ http://purl.uniprot.org/uniprot/F4G096 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1006006:MCUP_RS07755 ^@ http://purl.uniprot.org/uniprot/F4FZY9 ^@ Similarity ^@ Belongs to the DNA photolyase family. http://togogenome.org/gene/1006006:MCUP_RS07135 ^@ http://purl.uniprot.org/uniprot/F4FZ51 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1006006:MCUP_RS01740 ^@ http://purl.uniprot.org/uniprot/F4FZD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS00600 ^@ http://purl.uniprot.org/uniprot/F4FYA7 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/1006006:MCUP_RS02260 ^@ http://purl.uniprot.org/uniprot/F4G050 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/1006006:MCUP_RS02385 ^@ http://purl.uniprot.org/uniprot/F4G074 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/1006006:MCUP_RS06510 ^@ http://purl.uniprot.org/uniprot/F4FYJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS08270 ^@ http://purl.uniprot.org/uniprot/F4G0G7 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 2 family. http://togogenome.org/gene/1006006:MCUP_RS04280 ^@ http://purl.uniprot.org/uniprot/F4G2A4 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1006006:MCUP_RS07390 ^@ http://purl.uniprot.org/uniprot/F4FZI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS00170 ^@ http://purl.uniprot.org/uniprot/F4FXU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1006006:MCUP_RS09450 ^@ http://purl.uniprot.org/uniprot/F4G1T4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/1006006:MCUP_RS04550 ^@ http://purl.uniprot.org/uniprot/F4G2F9 ^@ Caution|||Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS09365 ^@ http://purl.uniprot.org/uniprot/F4G1R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS03045 ^@ http://purl.uniprot.org/uniprot/F4G109 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/1006006:MCUP_RS08450 ^@ http://purl.uniprot.org/uniprot/F4G0T3 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/1006006:MCUP_RS02300 ^@ http://purl.uniprot.org/uniprot/F4G058 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS00345 ^@ http://purl.uniprot.org/uniprot/F4FXX7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/1006006:MCUP_RS02170 ^@ http://purl.uniprot.org/uniprot/F4G032 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/1006006:MCUP_RS00090 ^@ http://purl.uniprot.org/uniprot/F4G3D0 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/1006006:MCUP_RS01850 ^@ http://purl.uniprot.org/uniprot/F4FZP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/1006006:MCUP_RS05490 ^@ http://purl.uniprot.org/uniprot/F4G377 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).|||Cell membrane|||Membrane http://togogenome.org/gene/1006006:MCUP_RS08460 ^@ http://purl.uniprot.org/uniprot/F4G0T5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS00680 ^@ http://purl.uniprot.org/uniprot/F4FYC3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/1006006:MCUP_RS01575 ^@ http://purl.uniprot.org/uniprot/F4FZA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1006006:MCUP_RS09500 ^@ http://purl.uniprot.org/uniprot/F4G223 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS00255 ^@ http://purl.uniprot.org/uniprot/F4FXW1 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/1006006:MCUP_RS01915 ^@ http://purl.uniprot.org/uniprot/F4FZQ3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS02225 ^@ http://purl.uniprot.org/uniprot/F4G042 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/1006006:MCUP_RS00745 ^@ http://purl.uniprot.org/uniprot/F4FYD6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1006006:MCUP_RS09325 ^@ http://purl.uniprot.org/uniprot/F4G1R1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS01525 ^@ http://purl.uniprot.org/uniprot/F4FZ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS01270 ^@ http://purl.uniprot.org/uniprot/F4FYW7 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1006006:MCUP_RS02515 ^@ http://purl.uniprot.org/uniprot/F4G0A1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/1006006:MCUP_RS09410 ^@ http://purl.uniprot.org/uniprot/F4G1S7 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/1006006:MCUP_RS01025 ^@ http://purl.uniprot.org/uniprot/F4FYS1 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/1006006:MCUP_RS05500 ^@ http://purl.uniprot.org/uniprot/F4G379 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/1006006:MCUP_RS01555 ^@ http://purl.uniprot.org/uniprot/F4FZA2 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/1006006:MCUP_RS02140 ^@ http://purl.uniprot.org/uniprot/F4FZU6 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/1006006:MCUP_RS09585 ^@ http://purl.uniprot.org/uniprot/F4G236 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/1006006:MCUP_RS00960 ^@ http://purl.uniprot.org/uniprot/F4FYQ6 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/1006006:MCUP_RS02220 ^@ http://purl.uniprot.org/uniprot/F4G041 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1006006:MCUP_RS00140 ^@ http://purl.uniprot.org/uniprot/F4G3D9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/1006006:MCUP_RS02270 ^@ http://purl.uniprot.org/uniprot/F4G052 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/1006006:MCUP_RS04090 ^@ http://purl.uniprot.org/uniprot/F4G266 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS07275 ^@ http://purl.uniprot.org/uniprot/F4FZG1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/1006006:MCUP_RS08755 ^@ http://purl.uniprot.org/uniprot/F4G171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS07170 ^@ http://purl.uniprot.org/uniprot/F4FZ58 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/1006006:MCUP_RS09020 ^@ http://purl.uniprot.org/uniprot/F4G1C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. LysZ subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). http://togogenome.org/gene/1006006:MCUP_RS01470 ^@ http://purl.uniprot.org/uniprot/F4FZ87 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1006006:MCUP_RS01905 ^@ http://purl.uniprot.org/uniprot/F4FZQ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/1006006:MCUP_RS09255 ^@ http://purl.uniprot.org/uniprot/F4G1P6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1006006:MCUP_RS06145 ^@ http://purl.uniprot.org/uniprot/F4FY38 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1006006:MCUP_RS06935 ^@ http://purl.uniprot.org/uniprot/F4FZ13 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/1006006:MCUP_RS08910 ^@ http://purl.uniprot.org/uniprot/F4G1A3 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/1006006:MCUP_RS01460 ^@ http://purl.uniprot.org/uniprot/F4FZ85 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1006006:MCUP_RS06720 ^@ http://purl.uniprot.org/uniprot/F4FYN7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1006006:MCUP_RS08470 ^@ http://purl.uniprot.org/uniprot/F4G0T8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS06820 ^@ http://purl.uniprot.org/uniprot/F4FYY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.|||Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1006006:MCUP_RS09535 ^@ http://purl.uniprot.org/uniprot/F4G227 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS07045 ^@ http://purl.uniprot.org/uniprot/F4FZ34 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/1006006:MCUP_RS01090 ^@ http://purl.uniprot.org/uniprot/F4FYT4 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/1006006:MCUP_RS06275 ^@ http://purl.uniprot.org/uniprot/F4FY71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1006006:MCUP_RS03125 ^@ http://purl.uniprot.org/uniprot/F4G125 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/1006006:MCUP_RS04610 ^@ http://purl.uniprot.org/uniprot/F4G2H5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.|||In the C-terminal section; belongs to the urease beta subunit family.|||In the N-terminal section; belongs to the urease gamma subunit family. http://togogenome.org/gene/1006006:MCUP_RS02755 ^@ http://purl.uniprot.org/uniprot/F4G0M7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS02460 ^@ http://purl.uniprot.org/uniprot/F4G090 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1006006:MCUP_RS00220 ^@ http://purl.uniprot.org/uniprot/F4FXV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS01885 ^@ http://purl.uniprot.org/uniprot/F4FZP7 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/1006006:MCUP_RS08435 ^@ http://purl.uniprot.org/uniprot/F4G0T0 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1006006:MCUP_RS06985 ^@ http://purl.uniprot.org/uniprot/F4FZ23 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/1006006:MCUP_RS06315 ^@ http://purl.uniprot.org/uniprot/F4FY81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/1006006:MCUP_RS06760 ^@ http://purl.uniprot.org/uniprot/F4FYP5 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/1006006:MCUP_RS00595 ^@ http://purl.uniprot.org/uniprot/F4FYA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS04895 ^@ http://purl.uniprot.org/uniprot/F4G2P2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 12 (cellulase H) family. http://togogenome.org/gene/1006006:MCUP_RS08480 ^@ http://purl.uniprot.org/uniprot/F4G0U0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS00470 ^@ http://purl.uniprot.org/uniprot/F4FY01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/1006006:MCUP_RS00095 ^@ http://purl.uniprot.org/uniprot/F4G3D1 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/1006006:MCUP_RS01455 ^@ http://purl.uniprot.org/uniprot/F4FZ84 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS05830 ^@ http://purl.uniprot.org/uniprot/F4G3H7 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1006006:MCUP_RS07335 ^@ http://purl.uniprot.org/uniprot/F4FZH4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS07945 ^@ http://purl.uniprot.org/uniprot/F4G027 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS01515 ^@ http://purl.uniprot.org/uniprot/F4FZ95 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS02645 ^@ http://purl.uniprot.org/uniprot/F4G0K6 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/1006006:MCUP_RS09310 ^@ http://purl.uniprot.org/uniprot/F4G1Q8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1006006:MCUP_RS02745 ^@ http://purl.uniprot.org/uniprot/F4G0M5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1006006:MCUP_RS06370 ^@ http://purl.uniprot.org/uniprot/F4FY93 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/1006006:MCUP_RS04490 ^@ http://purl.uniprot.org/uniprot/F4G2E6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/1006006:MCUP_RS06595 ^@ http://purl.uniprot.org/uniprot/F4FYL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/1006006:MCUP_RS00710 ^@ http://purl.uniprot.org/uniprot/F4FYC9 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1006006:MCUP_RS06775 ^@ http://purl.uniprot.org/uniprot/F4FYP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS02775 ^@ http://purl.uniprot.org/uniprot/F4G0N1 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/1006006:MCUP_RS05155 ^@ http://purl.uniprot.org/uniprot/F4G2V7 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1006006:MCUP_RS02115 ^@ http://purl.uniprot.org/uniprot/F4FZU1 ^@ Similarity ^@ Belongs to the EPSP synthase family. http://togogenome.org/gene/1006006:MCUP_RS07140 ^@ http://purl.uniprot.org/uniprot/F4FZ52 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/1006006:MCUP_RS01745 ^@ http://purl.uniprot.org/uniprot/F4FZD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS00555 ^@ http://purl.uniprot.org/uniprot/F4FY97 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1006006:MCUP_RS06140 ^@ http://purl.uniprot.org/uniprot/F4FY37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1006006:MCUP_RS00725 ^@ http://purl.uniprot.org/uniprot/F4FYD2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1006006:MCUP_RS03735 ^@ http://purl.uniprot.org/uniprot/F4G1V1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS00115 ^@ http://purl.uniprot.org/uniprot/F4G3D4 ^@ Similarity ^@ Belongs to the HTP reductase family. http://togogenome.org/gene/1006006:MCUP_RS09090 ^@ http://purl.uniprot.org/uniprot/F4G1D7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS06845 ^@ http://purl.uniprot.org/uniprot/F4FYZ2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1006006:MCUP_RS01565 ^@ http://purl.uniprot.org/uniprot/F4FZA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1006006:MCUP_RS01935 ^@ http://purl.uniprot.org/uniprot/F4FZQ7 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1006006:MCUP_RS00370 ^@ http://purl.uniprot.org/uniprot/F4FXY2 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1006006:MCUP_RS00080 ^@ http://purl.uniprot.org/uniprot/F4G3C8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1006006:MCUP_RS01865 ^@ http://purl.uniprot.org/uniprot/F4FZP3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS09435 ^@ http://purl.uniprot.org/uniprot/F4G1T1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/1006006:MCUP_RS00165 ^@ http://purl.uniprot.org/uniprot/F4FXU4 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/1006006:MCUP_RS05495 ^@ http://purl.uniprot.org/uniprot/F4G378 ^@ Subcellular Location Annotation ^@ Encapsulin nanocompartment http://togogenome.org/gene/1006006:MCUP_RS09405 ^@ http://purl.uniprot.org/uniprot/F4G1S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/1006006:MCUP_RS06805 ^@ http://purl.uniprot.org/uniprot/F4FYY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS03130 ^@ http://purl.uniprot.org/uniprot/F4G126 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS00760 ^@ http://purl.uniprot.org/uniprot/F4FYD9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1006006:MCUP_RS00505 ^@ http://purl.uniprot.org/uniprot/F4FY09 ^@ Caution|||Function|||Similarity ^@ Belongs to the TFIIB family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/1006006:MCUP_RS05850 ^@ http://purl.uniprot.org/uniprot/F4G3I1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/1006006:MCUP_RS02080 ^@ http://purl.uniprot.org/uniprot/F4FZT4 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS00250 ^@ http://purl.uniprot.org/uniprot/F4FXW0 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/1006006:MCUP_RS08720 ^@ http://purl.uniprot.org/uniprot/F4G164 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1006006:MCUP_RS06535 ^@ http://purl.uniprot.org/uniprot/F4FYK0 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/1006006:MCUP_RS08990 ^@ http://purl.uniprot.org/uniprot/F4G1B7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS00340 ^@ http://purl.uniprot.org/uniprot/F4FXX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.|||Homotetramer; dimer of dimers. http://togogenome.org/gene/1006006:MCUP_RS03090 ^@ http://purl.uniprot.org/uniprot/F4G118 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/1006006:MCUP_RS01275 ^@ http://purl.uniprot.org/uniprot/F4FYW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1006006:MCUP_RS08035 ^@ http://purl.uniprot.org/uniprot/F4G0C0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS05660 ^@ http://purl.uniprot.org/uniprot/F4G3E3 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1006006:MCUP_RS02760 ^@ http://purl.uniprot.org/uniprot/F4G0M8 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/1006006:MCUP_RS08175 ^@ http://purl.uniprot.org/uniprot/F4G0E8 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/1006006:MCUP_RS06335 ^@ http://purl.uniprot.org/uniprot/F4FY85 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS01610 ^@ http://purl.uniprot.org/uniprot/F4FZB2 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1006006:MCUP_RS08465 ^@ http://purl.uniprot.org/uniprot/F4G0T6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1006006:MCUP_RS00570 ^@ http://purl.uniprot.org/uniprot/F4FYA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02025 ^@ http://purl.uniprot.org/uniprot/F4FZS4 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1006006:MCUP_RS01260 ^@ http://purl.uniprot.org/uniprot/F4FYW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1006006:MCUP_RS03160 ^@ http://purl.uniprot.org/uniprot/F4G132 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02280 ^@ http://purl.uniprot.org/uniprot/F4G054 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/1006006:MCUP_RS00210 ^@ http://purl.uniprot.org/uniprot/F4FXV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS00135 ^@ http://purl.uniprot.org/uniprot/F4G3D8 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/1006006:MCUP_RS05875 ^@ http://purl.uniprot.org/uniprot/F4G3I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1006006:MCUP_RS00145 ^@ http://purl.uniprot.org/uniprot/F4G3E0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/1006006:MCUP_RS08600 ^@ http://purl.uniprot.org/uniprot/F4G0W8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/1006006:MCUP_RS07465 ^@ http://purl.uniprot.org/uniprot/F4FZK0 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS06305 ^@ http://purl.uniprot.org/uniprot/F4FY78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS08785 ^@ http://purl.uniprot.org/uniprot/F4G178 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1006006:MCUP_RS03175 ^@ http://purl.uniprot.org/uniprot/F4G135 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS00855 ^@ http://purl.uniprot.org/uniprot/F4FYF5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1006006:MCUP_RS00500 ^@ http://purl.uniprot.org/uniprot/F4FY08 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/1006006:MCUP_RS00695 ^@ http://purl.uniprot.org/uniprot/F4FYC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/1006006:MCUP_RS02155 ^@ http://purl.uniprot.org/uniprot/F4G029 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/1006006:MCUP_RS09415 ^@ http://purl.uniprot.org/uniprot/F4G1S8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1006006:MCUP_RS01880 ^@ http://purl.uniprot.org/uniprot/F4FZP6 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/1006006:MCUP_RS01890 ^@ http://purl.uniprot.org/uniprot/F4FZP8 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1006006:MCUP_RS08935 ^@ http://purl.uniprot.org/uniprot/F4G1A9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS05265 ^@ http://purl.uniprot.org/uniprot/F4G310 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/1006006:MCUP_RS01140 ^@ http://purl.uniprot.org/uniprot/F4FYU5 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1006006:MCUP_RS09260 ^@ http://purl.uniprot.org/uniprot/F4G1P7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS09475 ^@ http://purl.uniprot.org/uniprot/F4G1T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/1006006:MCUP_RS02105 ^@ http://purl.uniprot.org/uniprot/F4FZT9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1006006:MCUP_RS01560 ^@ http://purl.uniprot.org/uniprot/F4FZA3 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/1006006:MCUP_RS00785 ^@ http://purl.uniprot.org/uniprot/F4FYE4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1006006:MCUP_RS02485 ^@ http://purl.uniprot.org/uniprot/F4G095 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/1006006:MCUP_RS07435 ^@ http://purl.uniprot.org/uniprot/F4FZJ4 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.|||Belongs to the radical SAM superfamily. NifB family. http://togogenome.org/gene/1006006:MCUP_RS03900 ^@ http://purl.uniprot.org/uniprot/F4G1Y4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1006006:MCUP_RS02110 ^@ http://purl.uniprot.org/uniprot/F4FZU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02575 ^@ http://purl.uniprot.org/uniprot/F4G0J3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/1006006:MCUP_RS09605 ^@ http://purl.uniprot.org/uniprot/F4G240 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1006006:MCUP_RS03560 ^@ http://purl.uniprot.org/uniprot/F4G1I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1006006:MCUP_RS03775 ^@ http://purl.uniprot.org/uniprot/F4G1V9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS01595 ^@ http://purl.uniprot.org/uniprot/F4FZB0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS00390 ^@ http://purl.uniprot.org/uniprot/F4FXY6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/1006006:MCUP_RS01730 ^@ http://purl.uniprot.org/uniprot/F4FZD6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/1006006:MCUP_RS03625 ^@ http://purl.uniprot.org/uniprot/F4G1K5 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1006006:MCUP_RS00455 ^@ http://purl.uniprot.org/uniprot/F4FXZ8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS01820 ^@ http://purl.uniprot.org/uniprot/F4FZN4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS03230 ^@ http://purl.uniprot.org/uniprot/F4G146 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/1006006:MCUP_RS07010 ^@ http://purl.uniprot.org/uniprot/F4FZ27 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/1006006:MCUP_RS08650 ^@ http://purl.uniprot.org/uniprot/F4G0X9 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/1006006:MCUP_RS08790 ^@ http://purl.uniprot.org/uniprot/F4G179 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/1006006:MCUP_RS07380 ^@ http://purl.uniprot.org/uniprot/F4FZI3 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS05115 ^@ http://purl.uniprot.org/uniprot/F4G2U7 ^@ Similarity ^@ Belongs to the sterol desaturase family. http://togogenome.org/gene/1006006:MCUP_RS03035 ^@ http://purl.uniprot.org/uniprot/F4G107 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/1006006:MCUP_RS02730 ^@ http://purl.uniprot.org/uniprot/F4G0M2 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/1006006:MCUP_RS04800 ^@ http://purl.uniprot.org/uniprot/F4G2L7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS02580 ^@ http://purl.uniprot.org/uniprot/F4G0J4 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/1006006:MCUP_RS09600 ^@ http://purl.uniprot.org/uniprot/F4G239 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS01130 ^@ http://purl.uniprot.org/uniprot/F4FYU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1006006:MCUP_RS02700 ^@ http://purl.uniprot.org/uniprot/F4G0L6 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1006006:MCUP_RS01440 ^@ http://purl.uniprot.org/uniprot/F4FZ81 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/1006006:MCUP_RS01210 ^@ http://purl.uniprot.org/uniprot/F4FYV6 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/1006006:MCUP_RS08750 ^@ http://purl.uniprot.org/uniprot/F4G170 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/1006006:MCUP_RS06635 ^@ http://purl.uniprot.org/uniprot/F4FYM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS00350 ^@ http://purl.uniprot.org/uniprot/F4FXX8 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. http://togogenome.org/gene/1006006:MCUP_RS03030 ^@ http://purl.uniprot.org/uniprot/F4G106 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02210 ^@ http://purl.uniprot.org/uniprot/F4G039 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS02160 ^@ http://purl.uniprot.org/uniprot/F4G030 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1006006:MCUP_RS02150 ^@ http://purl.uniprot.org/uniprot/F4G028 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/1006006:MCUP_RS00810 ^@ http://purl.uniprot.org/uniprot/F4FYE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02380 ^@ http://purl.uniprot.org/uniprot/F4G073 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS08765 ^@ http://purl.uniprot.org/uniprot/F4G173 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/1006006:MCUP_RS08575 ^@ http://purl.uniprot.org/uniprot/F4G0W3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS02950 ^@ http://purl.uniprot.org/uniprot/F4G0Z1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1006006:MCUP_RS08670 ^@ http://purl.uniprot.org/uniprot/F4G0Y2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/1006006:MCUP_RS00430 ^@ http://purl.uniprot.org/uniprot/F4FXZ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1006006:MCUP_RS02455 ^@ http://purl.uniprot.org/uniprot/F4G089 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/1006006:MCUP_RS05510 ^@ http://purl.uniprot.org/uniprot/F4G381 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS03665 ^@ http://purl.uniprot.org/uniprot/F4G1L3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/1006006:MCUP_RS02425 ^@ http://purl.uniprot.org/uniprot/F4G083 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1006006:MCUP_RS04590 ^@ http://purl.uniprot.org/uniprot/F4G2H0 ^@ Similarity ^@ Belongs to the UreD family. http://togogenome.org/gene/1006006:MCUP_RS00175 ^@ http://purl.uniprot.org/uniprot/F4FXU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/1006006:MCUP_RS01435 ^@ http://purl.uniprot.org/uniprot/F4FZ80 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1006006:MCUP_RS09565 ^@ http://purl.uniprot.org/uniprot/F4G232 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/1006006:MCUP_RS05840 ^@ http://purl.uniprot.org/uniprot/F4G3H9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS08445 ^@ http://purl.uniprot.org/uniprot/F4G0T2 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/1006006:MCUP_RS08930 ^@ http://purl.uniprot.org/uniprot/F4G1A8 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1006006:MCUP_RS00720 ^@ http://purl.uniprot.org/uniprot/F4FYD1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1006006:MCUP_RS02495 ^@ http://purl.uniprot.org/uniprot/F4G097 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1006006:MCUP_RS05395 ^@ http://purl.uniprot.org/uniprot/F4G358 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1006006:MCUP_RS03690 ^@ http://purl.uniprot.org/uniprot/F4G1L8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1006006:MCUP_RS00275 ^@ http://purl.uniprot.org/uniprot/F4FXW5 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1006006:MCUP_RS09700 ^@ http://purl.uniprot.org/uniprot/F4G259 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS06650 ^@ http://purl.uniprot.org/uniprot/F4FYM3 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/1006006:MCUP_RS00045 ^@ http://purl.uniprot.org/uniprot/F4G3C2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/1006006:MCUP_RS00160 ^@ http://purl.uniprot.org/uniprot/F4FXU3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/1006006:MCUP_RS00360 ^@ http://purl.uniprot.org/uniprot/F4FXY0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/1006006:MCUP_RS00325 ^@ http://purl.uniprot.org/uniprot/F4FXX3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS06440 ^@ http://purl.uniprot.org/uniprot/F4FYI2 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/1006006:MCUP_RS09400 ^@ http://purl.uniprot.org/uniprot/F4G1S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS08120 ^@ http://purl.uniprot.org/uniprot/F4G0D7 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1006006:MCUP_RS00215 ^@ http://purl.uniprot.org/uniprot/F4FXV4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1006006:MCUP_RS05620 ^@ http://purl.uniprot.org/uniprot/F4G3A5 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/1006006:MCUP_RS08995 ^@ http://purl.uniprot.org/uniprot/F4G1B8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS02415 ^@ http://purl.uniprot.org/uniprot/F4G080 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/1006006:MCUP_RS02610 ^@ http://purl.uniprot.org/uniprot/F4G0K0 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/1006006:MCUP_RS04330 ^@ http://purl.uniprot.org/uniprot/F4G2B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1006006:MCUP_RS07520 ^@ http://purl.uniprot.org/uniprot/F4FZL1 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/1006006:MCUP_RS01810 ^@ http://purl.uniprot.org/uniprot/F4FZN2 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/1006006:MCUP_RS01635 ^@ http://purl.uniprot.org/uniprot/F4FZB7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS06645 ^@ http://purl.uniprot.org/uniprot/F4FYM2 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/1006006:MCUP_RS03070 ^@ http://purl.uniprot.org/uniprot/F4G114 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/1006006:MCUP_RS01030 ^@ http://purl.uniprot.org/uniprot/F4FYS2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS04510 ^@ http://purl.uniprot.org/uniprot/F4G2F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS00805 ^@ http://purl.uniprot.org/uniprot/F4FYE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/1006006:MCUP_RS08550 ^@ http://purl.uniprot.org/uniprot/F4G0V7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/1006006:MCUP_RS09300 ^@ http://purl.uniprot.org/uniprot/F4G1Q6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS03165 ^@ http://purl.uniprot.org/uniprot/F4G133 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/1006006:MCUP_RS05440 ^@ http://purl.uniprot.org/uniprot/F4G367 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS05675 ^@ http://purl.uniprot.org/uniprot/F4G3E6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1006006:MCUP_RS08305 ^@ http://purl.uniprot.org/uniprot/F4G0H4 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS09220 ^@ http://purl.uniprot.org/uniprot/F4G1N9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1006006:MCUP_RS06860 ^@ http://purl.uniprot.org/uniprot/F4FYZ5 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/1006006:MCUP_RS09345 ^@ http://purl.uniprot.org/uniprot/F4G1R5 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/1006006:MCUP_RS08150 ^@ http://purl.uniprot.org/uniprot/F4G0E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS02145 ^@ http://purl.uniprot.org/uniprot/F4FZU7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/1006006:MCUP_RS06215 ^@ http://purl.uniprot.org/uniprot/F4FY56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/1006006:MCUP_RS03700 ^@ http://purl.uniprot.org/uniprot/F4G1U4 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS06705 ^@ http://purl.uniprot.org/uniprot/F4FYN4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS08810 ^@ http://purl.uniprot.org/uniprot/F4G183 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS01420 ^@ http://purl.uniprot.org/uniprot/F4FZ77 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1006006:MCUP_RS09395 ^@ http://purl.uniprot.org/uniprot/F4G1S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/1006006:MCUP_RS05185 ^@ http://purl.uniprot.org/uniprot/F4G2W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1006006:MCUP_RS00450 ^@ http://purl.uniprot.org/uniprot/F4FXZ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/1006006:MCUP_RS00195 ^@ http://purl.uniprot.org/uniprot/F4FXV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/1006006:MCUP_RS09315 ^@ http://purl.uniprot.org/uniprot/F4G1Q9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1006006:MCUP_RS02215 ^@ http://purl.uniprot.org/uniprot/F4G040 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS09285 ^@ http://purl.uniprot.org/uniprot/F4G1Q3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS03055 ^@ http://purl.uniprot.org/uniprot/F4G111 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/1006006:MCUP_RS02050 ^@ http://purl.uniprot.org/uniprot/F4FZS8 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/1006006:MCUP_RS05400 ^@ http://purl.uniprot.org/uniprot/F4G359 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1006006:MCUP_RS07705 ^@ http://purl.uniprot.org/uniprot/F4FZX9 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/1006006:MCUP_RS06605 ^@ http://purl.uniprot.org/uniprot/F4FYL4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1006006:MCUP_RS01500 ^@ http://purl.uniprot.org/uniprot/F4FZ92 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS04060 ^@ http://purl.uniprot.org/uniprot/F4G219 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS03820 ^@ http://purl.uniprot.org/uniprot/F4G1W8 ^@ Similarity ^@ Belongs to the aconitase/IPM isomerase family. http://togogenome.org/gene/1006006:MCUP_RS02370 ^@ http://purl.uniprot.org/uniprot/F4G070 ^@ Function|||Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.|||Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. http://togogenome.org/gene/1006006:MCUP_RS00005 ^@ http://purl.uniprot.org/uniprot/F4G3B4 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1006006:MCUP_RS09460 ^@ http://purl.uniprot.org/uniprot/F4G1T6 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/1006006:MCUP_RS06625 ^@ http://purl.uniprot.org/uniprot/F4FYL8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1006006:MCUP_RS06655 ^@ http://purl.uniprot.org/uniprot/F4FYM4 ^@ Caution|||Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS04065 ^@ http://purl.uniprot.org/uniprot/F4G220 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS01645 ^@ http://purl.uniprot.org/uniprot/F4FZB9 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/1006006:MCUP_RS09690 ^@ http://purl.uniprot.org/uniprot/F4G257 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1006006:MCUP_RS04045 ^@ http://purl.uniprot.org/uniprot/F4G213 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1006006:MCUP_RS09320 ^@ http://purl.uniprot.org/uniprot/F4G1R0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/1006006:MCUP_RS00130 ^@ http://purl.uniprot.org/uniprot/F4G3D7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1006006:MCUP_RS04025 ^@ http://purl.uniprot.org/uniprot/F4G210 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1006006:MCUP_RS02595 ^@ http://purl.uniprot.org/uniprot/F4G0J7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1006006:MCUP_RS01910 ^@ http://purl.uniprot.org/uniprot/F4FZQ2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/1006006:MCUP_RS05150 ^@ http://purl.uniprot.org/uniprot/F4G2V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS04100 ^@ http://purl.uniprot.org/uniprot/F4G268 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS07910 ^@ http://purl.uniprot.org/uniprot/F4G020 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1006006:MCUP_RS06980 ^@ http://purl.uniprot.org/uniprot/F4FZ22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/1006006:MCUP_RS01075 ^@ http://purl.uniprot.org/uniprot/F4FYT1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS09230 ^@ http://purl.uniprot.org/uniprot/F4G1P1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS05820 ^@ http://purl.uniprot.org/uniprot/F4G3H5 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/1006006:MCUP_RS06735 ^@ http://purl.uniprot.org/uniprot/F4FYP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/1006006:MCUP_RS03975 ^@ http://purl.uniprot.org/uniprot/F4G1Z9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1006006:MCUP_RS01295 ^@ http://purl.uniprot.org/uniprot/F4FYX2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1006006:MCUP_RS08985 ^@ http://purl.uniprot.org/uniprot/F4G1B6 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1006006:MCUP_RS05280 ^@ http://purl.uniprot.org/uniprot/F4G313 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/1006006:MCUP_RS07375 ^@ http://purl.uniprot.org/uniprot/F4FZI2 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS09720 ^@ http://purl.uniprot.org/uniprot/F4G263 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/1006006:MCUP_RS09095 ^@ http://purl.uniprot.org/uniprot/F4G1D8 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/1006006:MCUP_RS01985 ^@ http://purl.uniprot.org/uniprot/F4FZR6 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/1006006:MCUP_RS06380 ^@ http://purl.uniprot.org/uniprot/F4FY95 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1006006:MCUP_RS06165 ^@ http://purl.uniprot.org/uniprot/F4FY43 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/1006006:MCUP_RS01665 ^@ http://purl.uniprot.org/uniprot/F4FZC3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS01750 ^@ http://purl.uniprot.org/uniprot/F4FZM0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/1006006:MCUP_RS04755 ^@ http://purl.uniprot.org/uniprot/F4G2K8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1006006:MCUP_RS02410 ^@ http://purl.uniprot.org/uniprot/F4G079 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/1006006:MCUP_RS01390 ^@ http://purl.uniprot.org/uniprot/F4FZ71 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1006006:MCUP_RS00460 ^@ http://purl.uniprot.org/uniprot/F4FXZ9 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1006006:MCUP_RS09265 ^@ http://purl.uniprot.org/uniprot/F4G1P9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1006006:MCUP_RS07485 ^@ http://purl.uniprot.org/uniprot/F4FZK4 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. http://togogenome.org/gene/1006006:MCUP_RS05825 ^@ http://purl.uniprot.org/uniprot/F4G3H6 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/1006006:MCUP_RS08265 ^@ http://purl.uniprot.org/uniprot/F4G0G6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1006006:MCUP_RS00750 ^@ http://purl.uniprot.org/uniprot/F4FYD7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1006006:MCUP_RS00380 ^@ http://purl.uniprot.org/uniprot/F4FXY4 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/1006006:MCUP_RS09240 ^@ http://purl.uniprot.org/uniprot/F4G1P3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1006006:MCUP_RS03080 ^@ http://purl.uniprot.org/uniprot/F4G116 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/1006006:MCUP_RS08830 ^@ http://purl.uniprot.org/uniprot/F4G187 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/1006006:MCUP_RS08820 ^@ http://purl.uniprot.org/uniprot/F4G185 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/1006006:MCUP_RS08845 ^@ http://purl.uniprot.org/uniprot/F4G190 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/1006006:MCUP_RS02780 ^@ http://purl.uniprot.org/uniprot/F4G0N2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1006006:MCUP_RS08200 ^@ http://purl.uniprot.org/uniprot/F4G0F3 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.