Calcium/calmodulin-dependent protein kinase type II subunit delta
Tumor necrosis factor-inducible gene 6 protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Helical; Voltage-sensor; Name=Segment S4
Phosphoserine; by CDK5, MAPK14; in vitro
Potassium voltage-gated channel subfamily B member 1
Translationally-controlled tumor protein
ATP-binding cassette sub-family C member 9
Phosphothreonine; by MTOR, NEK6 and NEK7
Schiff-base intermediate with substrate; via topaquinone
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Helical; Signal-anchor for type II membrane protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
Myosin light chain kinase 2, skeletal/cardiac muscle
Decreased affinity for glucose and phlorizin.
Drasticly decreased affinity for glucose and phlorizin.
Phosphatidylserine amidated glycine; alternate
Disintegrin and metalloproteinase domain-containing protein 20-like
Sodium-dependent multivitamin transporter
Chloride intracellular channel protein 1
Helical; Note=After insertion into the membrane
Sodium/potassium-transporting ATPase subunit beta-3
Sodium-dependent phosphate transport protein 1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
V(D)J recombination-activating protein 2
Sperm acrosome membrane-associated protein 3
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Gamma-aminobutyric acid receptor subunit alpha-1
Parathyroid hormone/parathyroid hormone-related peptide receptor
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Potassium voltage-gated channel subfamily S member 3
MHC_I-like_Ag-recog domain-containing protein
Ubiquitin carboxyl-terminal hydrolase 14
11-beta-hydroxysteroid dehydrogenase type 2
Amiloride-sensitive sodium channel subunit gamma
Phosphoserine; by PKC/PRKCG and PKC/PRKCD
High affinity immunoglobulin epsilon receptor subunit gamma
Voltage-dependent L-type calcium channel subunit beta-2
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Reverse transcriptase domain-containing protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Peptidyl-prolyl cis-trans isomerase FKBP1A
In isoform Skeletal 2 and isoform Skeletal 3.
Corticotropin-releasing factor receptor 1
Mesoderm induction early response protein 1
Phosphothreonine; by ROCK2 and PKC/PRKCI
Disintegrin and metalloproteinase domain-containing protein 2
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E
Blocked amino end (Ser); in form erythrocyte
receptor protein serine/threonine kinase
glycerophosphocholine cholinephosphodiesterase
cAMP-dependent protein kinase inhibitor alpha
Methylmalonic aciduria type A homolog, mitochondrial
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Potassium voltage-gated channel subfamily B member 2
Abolishes binding to the RFBP isoform of ATP11B.
Almost complete loss of Ca(2+) transport activity because of reduced Ca(2+) affinity.
Interferes with conformation changes that are essential for ATP-dependent Ca(2+) transport.
No loss of calcium binding. Strongly decreased rate of phosphorylation of the active site Asp residue. Interferes with conformation changes that are essential for ATP-dependent Ca(2+)transport.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Abolished phosphorylation without affecting calmodulin-binding.
Angiotensin-converting enzyme, soluble form
Mimics phosphorylation; does not affect calmodulin-binding.
No effect on activity. 20-fold reduction in catalytic efficiency; when associated with E-727.
No effect on activity. 20-fold reduction in catalytic efficiency; when associated with F-809.
Nucleophile; for phlorizin hydrolase/Glycosylceramidase activity
Proton donor; for phlorizin hydrolase/Glycosylceramidase activity
Microsomal triglyceride transfer protein large subunit
ADP-ribosylcysteine; by autocatalysis; in irreversibly inhibited form
Glyceraldehyde-3-phosphate dehydrogenase
S-nitrosocysteine; in reversibly inhibited form
Nuclear distribution protein nudE-like 1
S-palmitoyl cysteine; by ZDHHC2, ZDHHC3 and ZDHHC7
Voltage-dependent L-type calcium channel subunit beta-3
Tumor necrosis factor alpha-induced protein 8-like protein 2
Ankyrin repeat domain-containing protein 1
Membrane-spanning 4-domains subfamily A member 13
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Loss of self-glucosylation activity and 18 to 30-fold reduction in its ability to trans-glucosylate maltose. Reduces UDP-glucose hydrolytic activity by at least 190-fold.
Loss of self-glucosylation activity and ability to trans-glucosylate maltose. Reduces UDP-glucose hydrolytic activity by at least 190-fold.
Loss of self-glucosylation. No loss of catalytic activity.
Reduced trans-glucosylation activity by at least 260-fold and reduced UDP-glucose hydrolytic activity by 4 to 14-fold.
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Oxidized low-density lipoprotein receptor 1
Oxidized low-density lipoprotein receptor 1, soluble form
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Potassium voltage-gated channel subfamily D member 2
Short transient receptor potential channel 1
Solute carrier family 2, facilitated glucose transporter member 3
Triggering receptor expressed on myeloid cells 1
Acyl-coenzyme A amino acid N-acyltransferase 1
Abolishes cholesterol and 25-hydroxycholesterol binding.
No effect on cholesterol and 25-hydroxycholesterol binding.
Translation initiation factor eIF-2B subunit beta
Voltage-dependent calcium channel gamma-1 subunit
Impairs association with coatomer; when associated with 211-A-A-212.
Impairs association with coatomer; when associated with 215-S-S-216.
Transmembrane emp24 domain-containing protein 10
Phosphorylase b kinase regulatory subunit alpha, liver isoform
GDH/6PGL endoplasmic bifunctional protein
Jacalin-type lectin domain-containing protein
Aspartate 1-(chondroitin 4-sulfate)-ester
Inter-alpha-trypsin inhibitor heavy chain H3
N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternate
N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; partial
Peptidyl-prolyl cis-trans isomerase FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
Does not affect receptor internalization.
Soluble secretory phospholipase A2 receptor
Ubiquitin-like modifier-activating enzyme 1
39S ribosomal protein L51, mitochondrial
Bactericidal permeability-increasing protein
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Serine/threonine-protein kinase receptor
Translation initiation factor eIF-2B subunit delta
N6-(2-hydroxyisobutyryl)lysine; alternate
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
Translocon-associated protein subunit alpha
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Protein phosphatase 1 regulatory subunit 3A
Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranes
Tumor necrosis factor receptor superfamily member 1A
Potassium voltage-gated channel subfamily D member 3
Store-operated calcium entry-associated regulatory factor
Platelet-activating factor acetylhydrolase
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
N6-(beta-hydroxybutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Symmetric dimethylarginine; by PRMT5; alternate
Nearly abolishes inhibition of ATP2A1-mediated calcium uptake.
Reduces inhibition of ATP2A1-mediated calcium uptake.
Slightly reduces inhibition of ATP2A1-mediated calcium uptake.
Urokinase-type plasminogen activator chain B
Urokinase-type plasminogen activator long chain A
Urokinase-type plasminogen activator short chain A
WAP four-disulfide core domain protein 2
Peptidyl-prolyl cis-trans isomerase FKBP1B
DRY motif; important for ligand-induced conformation changes and signaling
NPxxY motif; important for ligand-induced conformation changes and signaling
Transforming growth factor-beta-induced protein ig-h3
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Sodium- and chloride-dependent betaine transporter
Translation initiation factor eIF-2B subunit epsilon
Decreases threshold for channel activation by K(+), caffeine and 4-chloro-m-cresol. Decreases inhibition by Mg(2+).
Loss of channel activation by halothane and caffeine due to Ca(2+) store depletion, probably due to constant Ca(2+) leakage through the mutant channel.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Heterogeneous nuclear ribonucleoprotein C
Dual specificity mitogen-activated protein kinase kinase 1
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Short transient receptor potential channel 5
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
High affinity immunoglobulin gamma Fc receptor I-like
Higher affinity for TEA, lower Vmax and loss of plasma membrane localization.
Higher affinity for TEA. Loss of plasma membrane localization; when associated with Q-76. Loss of plasma membrane localization; when associated with Q-112. Loss of plasma membrane localization; when associated with Q-76 and Q-112.
Hippocampal cholinergic neurostimulating peptide
Phosphatidylethanolamine-binding protein 1
Processed zona pellucida sperm-binding protein 1
RLA class I histocompatibility antigen, alpha chain 11/11
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Granulocyte-macrophage colony-stimulating factor
Plasma membrane calcium-transporting ATPase 1
Low affinity immunoglobulin gamma Fc region receptor II-b
DRY motif; important for ligand-induced conformation changes
Eukaryotic translation initiation factor 2 subunit 2
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Potassium voltage-gated channel subfamily A member 2
Growth hormone-releasing hormone receptor
Endoplasmic reticulum resident protein 29
Ig-like V-type 1; required for binding to polymeric IgA and IgM
N-linked (GlcNAc...) asparagine; in variant N-88
Potassium-transporting ATPase alpha chain 2
Aspartate aminotransferase, mitochondrial
N6-(pyridoxal phosphate)lysine; alternate
Mitochondrial brown fat uncoupling protein 1
Attenuates calcium block of inward barium, lithium, or cadmium currents.
Drastic reduction of barium permeability. Reduction of calcium block of lithium currents.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-393; A-1145 and A-1446.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-393; A-736 and A-1145.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-393; A-736 and A-1446.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-736; A-1145 and A-1446.
Loss of nifedipine-sensitivity and channel activity; when associated with P-775.
Loss of nifedipine-sensitivity and channel activity; when associated with Y-1066.
Mildly decreased interaction with STAC3.
Moderate reduction of barium permeability. Reduction of calcium block of lithium currents.
Slower channel activation and reduction of current amplitude.
Strongly decreased interaction with STAC3.
Strongly reduced channel clustering at the junctional membrane.
Voltage-dependent L-type calcium channel subunit alpha-1C
Protein arginine methyltransferase NDUFAF7
Transmembrane emp24 domain-containing protein 5
Extracellular superoxide dismutase [Cu-Zn]
Voltage-dependent anion-selective channel protein 2
Unique cartilage matrix-associated protein
Troponin C, slow skeletal and cardiac muscles
Interchain (between small and large subunit)
Large neutral amino acids transporter small subunit 2
Confers sensitivity to capsaicin, resiniferatoxin and other vanilloids and confers binding to resiniferatoxin; when associated with M-550. Reduces sensitivity to capsaicin more than 100-fold; when associated with A-514.
Confers sensitivity to capsaicin, resiniferatoxin and other vanilloids and confers binding to resiniferatoxin; when associated with T-553.
Phosphoserine; by PKC/PRKCE and PKC/PRKCZ
Reduces sensitivity to capsaicin more than 100-fold; when associated with T-553.
Transient receptor potential cation channel subfamily V member 1
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Calcium-activated potassium channel subunit alpha-1
5-glutamyl coenzyme A thioester intermediate
Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)
Sodium channel protein type 9 subunit alpha
Fibrillar collagen NC1 domain-containing protein
Calcium-independent phospholipase A2-gamma
Solute carrier family 2, facilitated glucose transporter member 1
non-specific serine/threonine protein kinase
DXXLL motif involved in the interaction with GGA1
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1
Glycine cleavage system H protein, mitochondrial
Cystic fibrosis transmembrane conductance regulator
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Immediate early response 3-interacting protein 1
Actin, aortic smooth muscle, intermediate form
Reduces calcium-sensitivity by over 10000-fold.
Nearly abolishes its ability to convert adenosine 5'-O-phosphorothioate into 5'-O-monophosphate.
No effect on its ability to convert adenosine 5'-O-phosphorothioate into 5'-O-monophosphate.
Dimethylaniline monooxygenase [N-oxide-forming] 2
Increases protein solubility in the absence of detergent.
Decreases cell membrane expression. Decreases succinate transport activity.
Decreases cell membrane expression. Decreases succinate transport activity. Decreases Km value for succinate.
Does not affect cell membrane localization. Abolishes succinate transport activity.
Does not affect cell membrane localization. Decreases succinate transport activity.
Does not affect cell membrane localization. Decreases succinate transport activity. Decreases Km value for succinate. More sensitive to inhibition by lithium.
Does not affect cell membrane localization. Decreases succinate transport activity. Insensitive to inhibition by lithium.
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Cholinergic receptor nicotinic alpha 10 subunit
G_PROTEIN_RECEP_F3_4 domain-containing protein
Calcium-activated potassium channel subunit beta-1
Eukaryotic translation initiation factor 4 gamma 2
Guanine nucleotide-binding protein subunit beta-5
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Odontogenic ameloblast-associated protein
Phosphatidylcholine-sterol acyltransferase
Helical; Signal-anchor for type III membrane protein
Interleukin-1 receptor antagonist protein
Tumor necrosis factor ligand superfamily member 4
Processed zona pellucida sperm-binding protein 4
Sodium/potassium-transporting ATPase subunit alpha-1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Sodium-dependent phosphate transport protein 2A
Interchain (between beta and alpha chains)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Eukaryotic translation initiation factor 2D
Lysosome-associated membrane glycoprotein 3
Electrogenic sodium bicarbonate cotransporter 1
Loss of interaction with STAC2 and STAC3 and strongly decreased channel activity; when associated with 752-AA-753.
Loss of interaction with STAC2 and STAC3 and strongly decreased channel activity; when associated with A-757.
Shifts the threshold potential to more negative values and lowers the concentration threshold for channel activation by caffeine.
Voltage-dependent L-type calcium channel subunit alpha-1S
Helical; Anchor for type IV membrane protein
Sodium/potassium-transporting ATPase subunit beta-1
NAD(P)(+)--arginine ADP-ribosyltransferase
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Eukaryotic translation initiation factor 4E
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Deleted in malignant brain tumors 1 protein
Potassium voltage-gated channel subfamily A member 5
Phosphatidylinositol transfer protein alpha isoform
T-cell surface glycoprotein CD3 zeta chain
Interchain (with C-60 in C8-gamma chain)
4-carboxyglutamate; in a patient with Moyamoya disease
Schiff-base intermediate with dihydroxyacetone-P
Alters protein-protein interactions, leading to a dimeric protein.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Interchain (between alpha-2-1 and delta-1 chains)
Voltage-dependent calcium channel subunit alpha-2-1
Voltage-dependent calcium channel subunit alpha-2/delta-1
Voltage-dependent calcium channel subunit delta-1
Amiloride-sensitive sodium channel subunit alpha
Insulin-like growth factor-binding protein 4
Voltage-gated potassium channel subunit beta-1
Nuclear export signal; masked by the interaction with BRCA2
Insulin-like growth factor-binding protein 5
Macrophage scavenger receptor types I and II
Impaired GHR-mediated GH internalization.
Impaired GHR-mediated GH internalization. Greatly reduced ubiquitination.
No effect on GHR-mediated GH internalization.
No effect on GHR-mediated GH internalization. No effect on ubiquitination.
Slightly impaired GHR-mediated GH internalization.
Sodium/potassium-transporting ATPase subunit beta-2
Gamma-aminobutyric acid receptor-associated protein
Phosphatidylethanolamine amidated glycine; alternate
Tumor necrosis factor receptor superfamily member 11B
Calcitonin gene-related peptide type 1 receptor
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
O-linked (Xyl...) (glycosaminoglycan) serine
Aryl hydrocarbon receptor nuclear translocator
Pulmonary surfactant-associated protein B
Receptor-binding cancer antigen expressed on SiSo cells
Dimethylaniline monooxygenase [N-oxide-forming] 4
Reduces enzyme activity and alters specificity, so that NADP can be used as cosubstrate.
Acyl-CoA-binding domain-containing protein 5
'Ionic lock' involved in activated form stabilization
Eukaryotic peptide chain release factor subunit 1
NIKS motif; plays an important role in translational termination
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Lutropin-choriogonadotropic hormone receptor
Interchain (between alpha and beta chains)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Amiloride-sensitive sodium channel subunit beta
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Calcium-binding mitochondrial carrier protein SCaMC-1
Low affinity immunoglobulin gamma Fc region receptor III-B
Voltage-dependent L-type calcium channel subunit beta-1
T-cell-specific surface glycoprotein CD28
N-acetyllactosaminide alpha-1,3-galactosyltransferase-like
Changes the stereoselectivity of the oxygenation reaction to produce (12S)-HPETE instead of (15S)-HPETE.
Decreases 15 lipoxygenase activity. Exhibits hepoxilin A3 synthase activity.
Polyunsaturated fatty acid lipoxygenase ALOX15
V(D)J recombination-activating protein 1
Voltage-dependent anion-selective channel protein 1
Low affinity immunoglobulin gamma Fc region receptor III-A
Serine/threonine-protein phosphatase 4 catalytic subunit
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Cytochrome c oxidase subunit 6A1, mitochondrial
Low-density lipoprotein receptor-related protein
Glutathione S-transferase alpha I, N-terminally processed
N-acetylalanine; in Glutathione S-transferase alpha I, N-terminally processed
Growth hormone secretagogue receptor type 1
Myosin light chain 1/3, skeletal muscle isoform
5-glutamyl glycerylphosphorylethanolamine
N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT3
N6,N6-dimethyllysine; alternate; by EEF1AKMT3
N6-methyllysine; alternate; by EEF1AKMT3
Peptidyl-prolyl cis-trans isomerase FKBP3