Mitochondrial brown fat uncoupling protein 1
Odontogenic ameloblast-associated protein
Abolishes GlcCer binding. No effect on membrane tubulation.
No binding of PtdIns4P. Very little induction of membrane tubulation.
Pleckstrin homology domain-containing family A member 8
Psoriasis susceptibility 1 candidate gene 2 protein
O-linked (Xyl...) (glycosaminoglycan) serine
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Interchain (between alpha and beta chains)
Protein transport protein Sec61 subunit beta
Helical; Signal-anchor for type II membrane protein
O-linked (GalNAc...) serine; in soluble form
Decreases interaction with DYNLT1; when associated with A-138.
Decreases interaction with DYNLT1; when associated with A-139.
Disrupts interaction with DYNLT1; when associated with A-150.
Disrupts interaction with DYNLT1; when associated with A-151.
Rho guanine nucleotide exchange factor 2
Dipeptidyl peptidase 1 exclusion domain chain
Cystic fibrosis transmembrane conductance regulator
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Guanylate cyclase soluble subunit beta-1
dolichyl-phosphate beta-glucosyltransferase
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Scavenger receptor cysteine-rich type 1 protein M130
T-cell-specific surface glycoprotein CD28
Tumor necrosis factor receptor superfamily member 6
Breast cancer type 1 susceptibility protein homolog
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Translocon-associated protein subunit beta
Triggering receptor expressed on myeloid cells 1
Interchain (between beta and alpha chains)
Protein transport protein Sec61 subunit gamma
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
N-linked (GlcNAc...) (high mannose) asparagine
N6-(2-hydroxyisobutyryl)lysine; alternate
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Zinc finger BED domain-containing protein 5
Cyclic nucleotide-gated cation channel beta-3
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Lipocln_cytosolic_FA-bd_dom domain-containing protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Solute carrier family 2, facilitated glucose transporter member 4
Signal recognition particle 19 kDa protein
Neuronal acetylcholine receptor subunit alpha-7
Oligosaccharyltransferase complex subunit OSTC
Hematopoietic progenitor cell antigen CD34
Vacuolar protein sorting-associated protein 52 homolog
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
Rap guanine nucleotide exchange factor 2
dolichyl-phosphate-mannose--protein mannosyltransferase
von Hippel-Lindau disease tumor suppressor
Cocaine- and amphetamine-regulated transcript protein
Abolishes regulation by micromolar Ca(2+).
Decreases affinity for Ca(2+), but retains regulation by micromolar Ca(2+).
No effect on regulation by micromolar Ca(2+).
Serine/threonine-protein kinase receptor
Abolishes tiotidine, but not cimetidine binding.
Diminishes histamine-stimulated activity.
T-cell surface glycoprotein CD3 epsilon chain
Baculoviral IAP repeat-containing protein 5
1-acyl-sn-glycerol-3-phosphate acyltransferase
Nuclear receptor subfamily 4 group A member 1
Phosphoserine; by PKA, RPS6KA1 and RPS6KA3
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Protein kinase C delta type catalytic subunit
Protein kinase C delta type regulatory subunit
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Translocon-associated protein subunit delta
Hepatocyte growth factor activator long chain
Hepatocyte growth factor activator short chain
Interchain (between short and long chains)
Retinoic acid receptor responder protein 2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Ferritin heavy chain, N-terminally processed
N-acetylthreonine; in Ferritin heavy chain, N-terminally processed
Interleukin-1 receptor accessory protein-like 1
Aldehyde dehydrogenase, dimeric NADP-preferring
Tumor necrosis factor receptor superfamily member 1A
Disintegrin and metalloproteinase domain-containing protein 9
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Keratinocyte differentiation-associated protein
Platelet-derived growth factor receptor alpha
vitamin-K-epoxide reductase (warfarin-sensitive)
Transmembrane emp24 domain-containing protein 5
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit
Granulocyte-macrophage colony-stimulating factor
S-Lysyl-methionine sulfilimine (Lys-Met) (interchain with M-1555)
S-Lysyl-methionine sulfilimine (Met-Lys) (interchain with K-1673)
May be a predisposing factor for congenital dwarfism.
Pituitary-specific positive transcription factor 1
Platelet-derived growth factor subunit B
Multidrug resistance-associated protein 1
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Oxidized purine nucleoside triphosphate hydrolase
Asymmetric dimethylarginine; by CARM1; alternate
KH domain-containing RNA-binding protein QKI
Platelet-activating factor acetylhydrolase
Phosphoserine; by PKC/PRKCE and PKC/PRKCZ
Transient receptor potential cation channel subfamily V member 1
Signal recognition particle 54 kDa protein
Guanine nucleotide-binding protein G(i) subunit alpha-2
FXYD domain-containing ion transport regulator
Amiloride-sensitive sodium channel subunit beta
Signaling lymphocytic activation molecule
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Coiled-coil domain-containing protein 66
Cell division control protein 42 homolog
Polybasic region; required for nuclear import
Ras-related C3 botulinum toxin substrate 1
Interchain (between light and heavy chains)
Phosphotyrosine; by SRC-type Tyr-kinases
Reduces N-glycosylation but not apical targeting. Reduces strongly N-glycosylation but not apical targeting; when associated with Q-199 and Q-373.
Reduces N-glycosylation but not apical targeting. Reduces strongly N-glycosylation but not apical targeting; when associated with Q-199 and Q-383.
Reduces N-glycosylation but not apical targeting. Reduces strongly N-glycosylation but not apical targeting; when associated with Q-373 and Q-383.
Thioredoxin domain-containing protein 12
Methylated-DNA--protein-cysteine methyltransferase
Helical; Anchor for type IV membrane protein
Platelet-derived growth factor receptor-like protein
Lymphocyte antigen 6 complex locus protein G5c
Signal recognition particle subunit SRP68
Ubiquitin carboxyl-terminal hydrolase 37
DINNN-motif; mediates interaction with SPSB1, SPSB2 and SPSB4
Potassium-transporting ATPase alpha chain 1
Interchain (with C-99 in IL12A and C-76 in IL23A)
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Interchain (between heavy and light chains)
Sperm acrosome membrane-associated protein 3
Store-operated calcium entry-associated regulatory factor
Fibrinogen C-terminal domain-containing protein
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Guanine nucleotide-binding protein G(q) subunit alpha
Ciliary neurotrophic factor receptor subunit alpha
Tartrate-resistant acid phosphatase type 5
Platelet-derived growth factor receptor beta
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
EGF domain-specific O-linked N-acetylglucosamine transferase
B-cell antigen receptor complex-associated protein alpha chain
Abnormal spindle-like microcephaly-associated protein homolog
Phosphatidylserine amidated glycine; alternate
Signal recognition particle subunit SRP72
S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate
WAP four-disulfide core domain protein 2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Solute carrier family 40 protein member 1
Tumor necrosis factor receptor superfamily member 11B
Actin, cytoplasmic 1, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed
Receptor-type tyrosine-protein phosphatase alpha
non-specific serine/threonine protein kinase
Dolichol-phosphate mannosyltransferase subunit 3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Peroxisome proliferator-activated receptor alpha
Insulin-like growth factor-binding protein 1
In MCR; profound effect on the voltage-dependence of activation such that mutant channels have a greatly reduced open probability at voltages near the resting membrane potential of skeletal muscle.
Vesicular integral-membrane protein VIP36
Nuclear export signal; masked by the interaction with BRCA2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Helical; Voltage-sensor; Name=Segment S4
Potassium voltage-gated channel subfamily A member 2
Dihydrolipoyl dehydrogenase, mitochondrial
Collagen like tail subunit of asymmetric acetylcholinesterase
cGMP-specific 3',5'-cyclic phosphodiesterase
Epididymal secretory glutathione peroxidase
Phorbol-12-myristate-13-acetate-induced protein 1
GDP-fucose protein O-fucosyltransferase 1
von Willebrand factor A domain-containing protein 1
Zinc finger and BTB domain-containing protein 22
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Ceroid-lipofuscinosis neuronal protein 6 homolog
Calcitonin receptor-stimulating peptide 2
Ceroid-lipofuscinosis neuronal protein 5
Ceroid-lipofuscinosis neuronal protein 5, secreted form
Guanine nucleotide-binding protein G(s) subunit alpha
Potassium-transporting ATPase subunit beta
Signal peptidase complex catalytic subunit SEC11A
Calcium-activated potassium channel subunit alpha-1
Peroxisome proliferator-activated receptor delta
Processed zona pellucida sperm-binding protein 2
Decreasing protein levels. Loss of isomerohydrolase activity.
Decreasing protein levels. isomerohydrolase activity.
Does not affect isomerohydrolase activity.
Signal peptidase complex catalytic subunit SEC11C
O-linked (GalNAc...) threonine; alternate
Mast/stem cell growth factor receptor Kit
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Calcitonin receptor-stimulating peptide 1
Helical; Signal-anchor for type III membrane protein
Receptor-binding cancer antigen expressed on SiSo cells
Sperm acrosome-associated protein 5-like
Natural cytotoxicity triggering receptor 3
Important for interaction with G proteins
Parathyroid hormone/parathyroid hormone-related peptide receptor
4-carboxyglutamate; in a patient with Moyamoya disease
Protein-glutamine gamma-glutamyltransferase K
Peroxisome proliferator-activated receptor gamma
Insulin-like growth factor-binding protein 4
Tumor necrosis factor receptor superfamily member 5
Polypeptide N-acetylgalactosaminyltransferase
Dual specificity mitogen-activated protein kinase kinase 2
Almost abolishes enzyme activity. Abolishes enzyme activity; when associated with A-396 or N-396.
Almost abolishes enzyme activity. Abolishes enzyme activity; when associated with A-521 or N-521.
3-fold activation of taurine uptake; abolishes phosphorylation by PKC.
No effect on taurine uptake; no effect on phosphorylation by PKC.
Sodium- and chloride-dependent taurine transporter
X-linked retinitis pigmentosa GTPase regulator
Guanine nucleotide-binding protein G(t) subunit alpha-1
Insulin-like growth factor-binding protein 5
Vitamin K-dependent protein C heavy chain
Vitamin K-dependent protein C light chain
Interferon-induced GTP-binding protein Mx1
Interleukin-1 receptor antagonist protein
O-linked (Gal...) hydroxylysine; alternate
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
In a bob-tailed dog; alters the ability of the protein to bind to its consensus DNA target.
Decreased IgE reactivity by approximately 15% compared to wild-type.
Decreased IgE reactivity by approximately 7% compared to wild-type.
Phosphoserine; by PKA, PKG/PRKG1, PKC and ROCK1
Phosphothreonine; by PKA, PKG/PRKG1 and AMPK
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E
Fms related receptor tyrosine kinase 3 ligand
Helical; Voltage-sensor; Name=S4 of repeat I
Helical; Voltage-sensor; Name=S4 of repeat II
Helical; Voltage-sensor; Name=S4 of repeat III
Helical; Voltage-sensor; Name=S4 of repeat IV
Sodium channel protein type 10 subunit alpha
DLA class II histocompatibility antigen, DR-1 beta chain
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
In narcolepsy; autosomal recessive; loss of function.
Protein transport protein Sec61 subunit alpha isoform 1
Mesoderm induction early response protein 1
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Disintegrin and metalloproteinase domain-containing protein 18-like
Golgi associated olfactory signaling regulator
Low-density lipoprotein receptor-related protein
Guanylate cyclase soluble subunit alpha-1
Unique cartilage matrix-associated protein
Creates an additional N-glycosylation site. Decreases calcium binding and increases the rate of spontaneous Ca(2+) release from myocytes.
Gamma-aminobutyric acid receptor subunit gamma-2
Dominant negative mutant that impairs vesicular protein transport.
Sodium/potassium-transporting ATPase subunit alpha-1
Asymmetric dimethylarginine; by PRMT6; alternate
Omega-N-methylarginine; by PRMT6; alternate
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
CEA cell adhesion molecule 16, tectorial membrane component
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Corticotropin-releasing factor-binding protein
Acyl-CoA-binding domain-containing protein 5
DRY motif; important for ligand-induced conformation changes and signaling
Sodium- and chloride-dependent betaine transporter
Calcitonin gene-related peptide type 1 receptor
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
Schiff-base intermediate with substrate; via topaquinone
C5a anaphylatoxin chemotactic receptor 1
receptor protein serine/threonine kinase
Natural resistance-associated macrophage protein 1
T-cell surface glycoprotein CD8 alpha chain
Calcium-activated potassium channel subunit beta-1
T-cell surface glycoprotein CD3 delta chain
Interchain (with C-1359 or C-1384 in LTBP1); in inactive form
Transmembrane emp24 domain-containing protein 11
Processed zona pellucida sperm-binding protein 3
Solute carrier family 2, facilitated glucose transporter member 3
Corticotropin-releasing factor receptor 1
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Translocating chain-associated membrane protein 1
ATP-dependent 6-phosphofructokinase, muscle type
Hairy/enhancer-of-split related with YRPW motif protein 1
Post-GPI attachment to proteins factor 3
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Thyroid adenoma-associated protein homolog
G_PROTEIN_RECEP_F3_4 domain-containing protein
Translocon-associated protein subunit alpha
Baculoviral IAP repeat-containing protein 3
cAMP-dependent protein kinase catalytic subunit alpha
Signal recognition particle 14 kDa protein
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Impairs normal protein trafficking through early endosomes.
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
TYRO protein tyrosine kinase-binding protein
Interferon-induced GTP-binding protein Mx2
N6,N6,N6-trimethyllysine; by METTL21A; alternate
Bactericidal permeability-increasing protein
Dual serine/threonine and tyrosine protein kinase
Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis
Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis
Potassium voltage-gated channel subfamily B member 2
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Acid sphingomyelinase-like phosphodiesterase
Frequent in Golden retrievers and Labrador retrievers.
NPC intracellular cholesterol transporter 2
Inactive pancreatic lipase-related protein 1
Removes steric hindrance and restores lipase activity; when associated with A-196.
Removes steric hindrance and restores lipase activity; when associated with P-198.
Cysteine sulfonic acid (-SO3H); alternate
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Potassium voltage-gated channel subfamily H member 2
High affinity immunoglobulin epsilon receptor subunit gamma
Pituitary adenylate cyclase-activating polypeptide
'Ionic lock' involved in activated form stabilization
Hippocampal cholinergic neurostimulating peptide
Phosphatidylethanolamine-binding protein 1
Found in dogs with neurodegenerative disease.
glycerophosphocholine cholinephosphodiesterase
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase