Abolishes phosphorylation by cdk2; when associated with A-153; A-177; A-215; A-226; A-239; A-255 and A-259.
Abolishes phosphorylation by cdk2; when associated with A-153; A-177; A-215; A-226; A-239; A-255 and A-264.
Abolishes phosphorylation by cdk2; when associated with A-153; A-177; A-215; A-226; A-239; A-259 and A-264.
Abolishes phosphorylation by cdk2; when associated with A-153; A-177; A-215; A-226; A-255; A-259 and A-264.
Abolishes phosphorylation by cdk2; when associated with A-153; A-177; A-215; A-239; A-255; A-259 and A-264.
Abolishes phosphorylation by cdk2; when associated with A-153; A-177; A-226; A-239; A-255; A-259 and A-264.
Abolishes phosphorylation by cdk2; when associated with A-153; A-215; A-226; A-239; A-255; A-259 and A-264.
Can still be phosphorylated by cdk2 in vitro. Abolishes phosphorylation by cdk2; when associated with A-177; A-215; A-226; A-239; A-255; A-259 and A-264.
Geminin coiled-coil domain-containing protein 1
Strongly reduces phosphorylation and interaction with cdk2 without affecting interaction with cdc45l.
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Serine/threonine-protein kinase receptor
Fibrinogen C domain-containing protein 1-B
Helical; Signal-anchor for type II membrane protein
Protein arginine N-methyltransferase 1-A
Glycerol-3-phosphate dehydrogenase 1-like protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Vascular endothelial growth factor receptor 3
Potassium voltage-gated channel subfamily D member 2
Helical; Anchor for type IV membrane protein
Regulator of G-protein signaling 9-binding protein B
Significantly reduces transcriptional activation activity. Impairs interaction with ctnnb1.
Volume-regulated anion channel subunit LRRC8E
FGGY carbohydrate kinase domain-containing protein
Ankyrin repeat domain-containing protein 13C-B
Neurogenic locus notch homolog protein 1
O-linked (GalNAc...) threonine; alternate
Meiosis expressed gene 1 protein homolog
Queuine tRNA-ribosyltransferase accessory subunit 2
E3 ubiquitin-protein ligase synoviolin A
Isochorismatase domain-containing protein 1
Nucleolar and spindle-associated protein 1-A
Sterol regulatory element-binding protein cleavage-activating protein
Vacuolar protein sorting-associated protein 26A-A
Hydroxysteroid 11-beta-dehydrogenase 1-like protein A
Eukaryotic peptide chain release factor subunit 1
NIKS motif; plays an important role in translational termination
Mitochondrial import inner membrane translocase subunit Tim10 B
CCR4-NOT transcription complex subunit 7
Gamma-aminobutyric acid receptor subunit alpha-2
F-box-like/WD repeat-containing protein TBL1XR1-A
Cilia- and flagella-associated protein 298-A
Lutropin-choriogonadotropic hormone receptor
Double-strand-break repair protein rad21 homolog
Deleted in malignant brain tumors 1 protein
Nuclear distribution protein nudE homolog 1-A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
N6-(2-hydroxyisobutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Sodium-coupled neutral amino acid transporter 7
Platelet-derived growth factor receptor alpha
DNA replication complex GINS protein PSF3
Thioredoxin domain-containing protein 15
RNA-binding protein with multiple splicing 2
Repressor of RNA polymerase III transcription MAF1 homolog
Ubiquitin carboxyl-terminal hydrolase 16
Schiff-base intermediate with substrate; via topaquinone
Mediator of RNA polymerase II transcription subunit 4
Calcium-binding mitochondrial carrier protein SCaMC-2
Coiled-coil domain-containing protein 172
Interchain (between beta and alpha chains)
Isoglutamyl cysteine thioester (Cys-Gln)
Myb-related transcription factor, partner of profilin
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
Guanine nucleotide-binding protein G(q) subunit alpha
POU domain, class 3, transcription factor 1-A
Heterogeneous nuclear ribonucleoprotein A2 homolog 2
Glutathione S-transferase C-terminal domain-containing protein
Cell adhesion molecule-related/down-regulated by oncogenes
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Mediator of RNA polymerase II transcription subunit 22
Ankyrin repeat domain-containing protein SOWAHB
DNA repair protein complementing XP-A cells homolog
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Mitochondrial intermembrane space import and assembly protein 40-B
Bridge-like lipid transfer protein family member 3B
Threonylcarbamoyladenosine tRNA methylthiotransferase
NAD(P)(+)--arginine ADP-ribosyltransferase
DNA-directed RNA polymerase I subunit RPA49
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Coiled-coil domain-containing protein 85C
Vacuolar protein sorting-associated protein 72 homolog
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A
Iroquois-class homeodomain protein irx-1-A
Asymmetric dimethylarginine; by PRMT1; alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Omega-N-methylarginine; by PRMT1; alternate
Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate
Transcription factor IIIB 50 kDa subunit
Eukaryotic translation initiation factor 3 subunit L
CAP-Gly domain-containing linker protein 3
Constitutively active. Displays defective GTPase activity and fails to respond to ral-GAP. Still able to bind ralbp1. Injection into embryos disrupts the actin cytoskeleton and the localization of pigment granules.
Dominant negative. Shows decreased GTP affinity. Injection into embryos disrupts gastrulation.
Results are conflicting as to whether binding of the GTP-bound form to ralbp1 is abolished.
Protein phosphatase 1 regulatory subunit 3C
Gamma-aminobutyric acid receptor subunit gamma-2
Interferon regulatory factor 2-binding protein-like A
Actin, alpha skeletal muscle 3, intermediate form
N-acetylaspartate; in Actin, alpha skeletal muscle 3
Mitogen-activated protein kinase kinase kinase 10
Does not induce t/bra expression; when associated A-728. Induces t/bra expression; when associated with E-728.
Induces t/bra expression; when associated with 662-CTC-664.
Inhibits t/bra expression and mesoderm induction.
Signal transducer and activator of transcription 3.1
Dehydrogenase/reductase SDR family member 6
Eukaryotic translation initiation factor 3 subunit B
Calcium release-activated calcium channel protein 1
Katanin p60 ATPase-containing subunit A-like 2
Cytosolic Fe-S cluster assembly factor nubp1-B
Guanine nucleotide-binding protein subunit alpha-11
Voltage-gated potassium channel subunit beta-3
Tartrate-resistant acid phosphatase type 5
BUB3-interacting and GLEBS motif-containing protein ZNF207
Proton acceptor; for processing activity
Schiff-base intermediate with substrate; via pyruvic acid
CaM kinase-like vesicle-associated protein
Mitochondrial fission regulator 1-like-B
Ras association domain-containing protein 10
Spindle and kinetochore-associated protein 3
Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial
10-fold reduction in ssDNA binding affinity; when associated with E-385.
10-fold reduction in ssDNA binding affinity; when associated with E-386.
Complete loss of activity to induce the Wnt target gene Siamois expression.
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Serine/threonine/tyrosine-interacting protein B
Sodium-dependent phosphate transporter 2
Amiloride-sensitive sodium channel subunit beta-2
Nucleoside diphosphate-linked moiety X motif 17
Serine/threonine-protein phosphatase 4 regulatory subunit 3-A
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Leucine-rich repeat-containing protein 58
Histone deacetylase complex subunit SAP130-A
Proton donor; shared with dimeric partner
Voltage-dependent L-type calcium channel subunit beta-2
Structural maintenance of chromosomes protein 5
Corticotropin-releasing factor receptor 1
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Glycine amidinotransferase, mitochondrial
Single-stranded DNA-binding protein 1-B, mitochondrial
Glial cell line-derived neurotrophic factor
POU domain, class 5, transcription factor 1.1
tRNA wybutosine-synthesizing protein 3 homolog
Hepatoma-derived growth factor-related protein 2
Leucine-rich repeat-containing protein 59
O-linked (Xyl...) (glycosaminoglycan) serine
Mediator of RNA polymerase II transcription subunit 29
Calcium-binding and coiled-coil domain-containing protein 1-B
Tubulin polymerization-promoting protein family member 3
Replication protein A 70 kDa DNA-binding subunit
Wilms tumor protein 1-interacting protein homolog
Acid sphingomyelinase-like phosphodiesterase
Nitric oxide synthase-interacting protein
Amiloride-sensitive sodium channel subunit gamma
Meiotic nuclear division protein 1 homolog
Cell death-inducing p53-target protein 1
Actin-related protein 2/3 complex subunit
Actin-related protein 2/3 complex subunit 1B-A
Charged multivesicular body protein 2b-A
NAD-dependent protein deacylase sirtuin-5B, mitochondrial
2-oxoadipate dehydrogenase complex component E1
Disrupts the helix-loop-helix structure. Reduces ability to inhibit bHLH complex formation.
Coiled-coil domain-containing protein 124-A
Abolishes threonine phosphorylation; when associated with S-260. No effect on phosphatase activity and MAPK1 binding; when associated with S-260.
Dual specificity protein phosphatase 1-A
Loss of phosphatase activity. Increases stability. Enables stable complex formation with active MAPK1. Abolishes threonine phosphorylation; when associated with E-168 or V-168. No effect on phosphatase activity and MAPK1 binding; when associated with E-168 or V-168.
Mitochondrial import receptor subunit TOM40 homolog
Heterogeneous nuclear ribonucleoprotein D-like-A
Receptor expression-enhancing protein 3-A
Serine/threonine-protein phosphatase 1 regulatory subunit 10
Almost completely abolishes suppression of secondary axis formation and organizer function, and disrupts ldb1 ubiquitination; when associated with A-591.
Almost completely abolishes suppression of secondary axis formation and organizer function, and disrupts ldb1 ubiquitination; when associated with A-594.
Mediator of RNA polymerase II transcription subunit 18
Low-density lipoprotein receptor-related protein
Glycosyltransferase-like domain-containing protein 1
Putative sodium-coupled neutral amino acid transporter 10
Methionine adenosyltransferase 2 subunit beta
Microtubule-associated tumor suppressor 1 homolog
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4
Zinc finger C2HC domain-containing protein 1A
Platelet-derived growth factor subunit B
Ubiquitin carboxyl-terminal hydrolase 10-A
Phosphatidylserine amidated glycine; alternate
Endothelial differentiation-related factor 1 homolog
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Neuroblastoma suppressor of tumorigenicity 1
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Histone-lysine N-methyltransferase KMT5B-B
Bromodomain adjacent to zinc finger domain protein 2A
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Influenza virus NS1A-binding protein homolog
Nuclear envelope integral membrane protein 1b
Coiled-coil domain-containing protein 78
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Nucleoside diphosphate-linked moiety X motif 6
Spermatid perinuclear RNA-binding protein
Sister chromatid cohesion protein PDS5 homolog A-B
GRB2-associated and regulator of MAPK protein
Serine/threonine-protein phosphatase 6 regulatory subunit 3-B
Corticotropin-releasing factor receptor 2
Zinc finger MYND domain-containing protein 10
Kinase inactive. Does not enhance rnf138/narf-mediated ubiquitination or association of rnf138/narf and tcf/lef.
Endoplasmic reticulum-Golgi intermediate compartment protein 1
Natural cytotoxicity triggering receptor 3
N-terminal Xaa-Pro-Lys N-methyltransferase 1-B
Alpha-ketoglutarate-dependent dioxygenase FTO
Sorting and assembly machinery component 50 homolog A
Programmed cell death 6-interacting protein
Maternal embryonic leucine zipper kinase
Coiled-coil domain-containing protein 69-B
WD repeat domain phosphoinositide-interacting protein 2
Regulator of G-protein signaling 9-binding protein A
Very-long-chain 3-oxoacyl-CoA reductase-A
5'-nucleotidase domain-containing protein 3
Endoplasmic reticulum junction formation protein lunapark
Myeloid-associated differentiation marker-like protein 2
BMP and activin membrane-bound inhibitor homolog
Abolishes phosphorylation, but no effect on caspase inhibitory activity; when associated with A-231; A-235; A-247 and A-251. No effect on protein stability or anti-apoptotic activity; when associated with A-235 and A-251.
Abolishes phosphorylation, but no effect on caspase inhibitory activity; when associated with A-231; A-235; A-247 and A-254. No effect on protein stability or anti-apoptotic activity; when associated with A-235 and A-254.
Abolishes phosphorylation, but no effect on caspase inhibitory activity; when associated with A-231; A-235; A-251 and A-254.
Abolishes phosphorylation, but no effect on caspase inhibitory activity; when associated with A-231; A-247; A-251 and A-254. No effect on protein stability or anti-apoptotic activity; when associated with A-251 and A-254.
Abolishes phosphorylation, but no effect on caspase inhibitory activity; when associated with A-235; A-247; A-251 and A-254.
Baculoviral IAP repeat-containing protein 7-A
No effect on caspase inhibitory activity or auto-ubiquitination activity; when associated with D-231; D-235; D-247 and D-251. No effect on protein stability or anti-apoptotic activity; when associated with D-235 and D-251.
No effect on caspase inhibitory activity or auto-ubiquitination activity; when associated with D-231; D-235; D-247 and D-254. No effect on protein stability or anti-apoptotic activity; when associated with D-235 and D-254.
No effect on caspase inhibitory activity or auto-ubiquitination activity; when associated with D-231; D-235; D-251 and D-254.
No effect on caspase inhibitory activity or auto-ubiquitination activity; when associated with D-231; D-247; D-251 and D-254.
No effect on caspase inhibitory activity or auto-ubiquitination activity; when associated with D-235; D-247; D-251 and D-254. No effect on protein stability or anti-apoptotic activity; when associated with D-235 and D-251.
Guided entry of tail-anchored proteins factor 1
ADP-ribosylation factor-like protein 2-binding protein
Mitogen-activated protein kinase kinase kinase 13-B
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
Active breakpoint cluster region-related protein
Chromatin modification-related protein MEAF6
Mannose-1-phosphate guanyltransferase beta-A
Serine/threonine-protein phosphatase 4 catalytic subunit
RNA transcription, translation and transport factor protein
28S ribosomal protein S24-A, mitochondrial
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
Symmetric dimethylarginine; by PRMT5; alternate
SEC14 domain and spectrin repeat-containing protein 1-A
V(D)J recombination-activating protein 1
MAP kinase-interacting serine/threonine-protein kinase 2
Abolishes activation of kinase activity of atr but no effect on atr binding. Defective in checkpoint regulation. No effect on DNA replication.
Phosphomimic. Exhibits minor defects in checkpoint activation.
Prevents phosphorylation. Prevents role in checkpoint activation.
Translocon-associated protein subunit alpha
Electron transfer flavoprotein beta subunit lysine methyltransferase
Xylosyl- and glucuronyltransferase LARGE2s
Pre-rRNA-processing protein TSR1 homolog
Phosphatidylinositol 4-kinase type 2-beta
Serine palmitoyltransferase small subunit B
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Cleavage and polyadenylation specificity factor subunit 2
FHF complex subunit HOOK interacting protein 2A
Embryonic polyadenylate-binding protein 2-A
Abolishes phosphorylation by atm and atr preventing spindle assembly inactivation.
Phospholipid phosphatase-related protein type 5
Uncharacterized protein KIAA2013 homolog
Dynein assembly factor with WDR repeat domains 1
Oligosaccharyltransferase complex subunit ostc-B
Leucine-rich repeat-containing protein 40
Schiff-base intermediate with acetaldehyde
Peroxisome proliferator-activated receptor delta
Mediator of RNA polymerase II transcription subunit 8-B
Vacuolar ATPase assembly integral membrane protein vma21
5-glutamyl glycerylphosphorylethanolamine
Mimics a phosphorylated residue. Retains a general neurogenic activity but severely impairs anterior marker-inducing abilities.
Retains ability to induce both general and anterior neural markers.
POU domain, class 3, transcription factor 4-B
Transcriptional activator protein Pur-beta-B
Mediator of RNA polymerase II transcription subunit 26
Actin-related protein 2/3 complex subunit 1B-B
Cytosolic Fe-S cluster assembly factor nubp2
Alpha/beta hydrolase domain-containing protein 17C
39S ribosomal protein L52, mitochondrial
Rap1 GTPase-GDP dissociation stimulator 1-A
Iroquois-class homeodomain protein irx-4-A
Trimeric intracellular cation channel type A
Amiloride-sensitive sodium channel subunit alpha
Transforming growth factor beta-1-induced transcript 1 protein
Coiled-coil domain-containing protein 102A
Dehydrogenase/reductase SDR family member 7B
T-cell surface glycoprotein CD8 alpha chain
Solute carrier family 2, facilitated glucose transporter member 12
Inhibits enzymatic activity. Induces duplication of the anterior dorsal axis.
Mediator of RNA polymerase II transcription subunit 15
Twisted gastrulation protein homolog 1-A
Mitochondrial inner membrane protease subunit 2
Decreased formation of basal bodies in multiciliated cells.
Thioredoxin-related transmembrane protein 2
Guanine nucleotide-binding protein G(i) subunit alpha-1
RNA-binding protein with serine-rich domain 1-B
Unique cartilage matrix-associated protein
DNA polymerase subunit gamma-2, mitochondrial
7-methylguanosine phosphate-specific 5'-nucleotidase B
Eukaryotic translation initiation factor 3 subunit E-B
Phosphoribosyltransferase domain-containing protein 1
Calcium-activated potassium channel subunit alpha-1
Helical; Voltage-sensor; Name=Segment S4
Mitochondrial import inner membrane translocase subunit Tim9
Protein phosphatase 1 regulatory subunit 26
RAC-alpha serine/threonine-protein kinase
RNA polymerase II-associated factor 1 homolog
Ciliated left-right organizer metallopeptidase
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Histone deacetylase complex subunit SAP30L-B
FXYD domain-containing ion transport regulator
Disintegrin and metalloproteinase domain-containing protein 10
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
Protein arginine methyltransferase NDUFAF7, mitochondrial
Gamma-aminobutyric acid receptor subunit alpha-1
Adenylyltransferase and sulfurtransferase MOCS3
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Abolished metalloprotease activity and ability to cleave covalent DNA-protein cross-links (DPCs).
Abolished metalloprotease activity and ability to cleave covalent DNA-protein cross-links (DPCs); when associated with 439-A--A-442.
Abolished metalloprotease activity and ability to cleave covalent DNA-protein cross-links (DPCs); when associated with 540-A--A-543.
Does not affect metalloprotease activity and ability to cleave covalent DNA-protein cross-links (DPCs).
Mitochondrial import inner membrane translocase subunit tim16-A
CDGSH iron-sulfur domain-containing protein 2A
Slightly decreases phosphorylation by CK2.
Palmitoleoyl-protein carboxylesterase notum1'
Major facilitator superfamily domain-containing protein 6-like protein A
Vacuolar protein sorting-associated protein 26A-B
Translation machinery-associated protein 16
LIM homeobox transcription factor 1-beta.1
CCR4-NOT transcription complex subunit 9
Choline/ethanolaminephosphotransferase 1
F-box-like/WD repeat-containing protein TBL1XR1-B
Mitochondrial import inner membrane translocase subunit Tim13-A
Serine/threonine-protein kinase pdik1l-B
Ubiquinol-cytochrome-c reductase complex assembly factor 3
No effect on interaction with dact1-B/dpr.
Segment polarity protein dishevelled homolog DVL-2
NEDD8-activating enzyme E1 regulatory subunit
TYRO protein tyrosine kinase-binding protein
Trichoplein keratin filament-binding protein
Proline-rich nuclear receptor coactivator 2 A
Embryonic polyadenylate-binding protein B
Transitional endoplasmic reticulum ATPase
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
DNA replication complex GINS protein SLD5
Actin-related protein 2/3 complex subunit 5-A
Palmitoleoyl-protein carboxylesterase notum1
receptor protein serine/threonine kinase
Zinc finger CCCH domain-containing protein 14
Isochorismatase domain-containing protein 2
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Baculoviral IAP repeat-containing protein 5.1-B
Cilia- and flagella-associated protein 299
eEF1A lysine and N-terminal methyltransferase
2-oxoglutarate dehydrogenase-like, mitochondrial
Armadillo-like helical domain-containing protein 3
RecQ-mediated genome instability protein 1
Mitochondrial ubiquitin ligase activator of nfkb 1
E3 ubiquitin-protein ligase synoviolin B
Nuclear distribution protein nudE-like 1-A
Phosphatidylinositol 3-kinase regulatory subunit alpha
Tumor necrosis factor alpha-induced protein 8
Probable mitochondrial glutathione transporter SLC25A40
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
SH3 domain-containing YSC84-like protein 1
N-alpha-acetyltransferase 38-A, NatC auxiliary subunit
Mast/stem cell growth factor receptor-related protein Kit
LHFPL tetraspan subfamily member 3 protein
Ubiquitin carboxyl-terminal hydrolase 20
S-adenosylmethionine mitochondrial carrier protein
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
KH domain-containing RNA-binding protein qki.L
X-ray repair cross-complementing protein 5
Iroquois-class homeodomain protein irx-1-B
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Cilia- and flagella-associated protein 20
Ubiquitin-like domain-containing CTD phosphatase 1
Pancreas transcription factor 1 subunit alpha
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Catalytically inactive. No effect on pronephros development.
Guanine nucleotide-binding protein G(s) subunit alpha
Katanin p80 WD40 repeat-containing subunit B1
Pyridoxal-dependent decarboxylase domain-containing protein 1
Protein N-terminal glutamine amidohydrolase
Eukaryotic translation initiation factor 3 subunit M
Solute carrier family 2, facilitated glucose transporter member 10
Zygotic DNA replication licensing factor mcm6-B
Cytoplasmic tRNA 2-thiolation protein 2-A
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Signal transducer and activator of transcription 3.2
Protein kinase C and casein kinase substrate in neurons protein 2
Coiled-coil domain-containing protein 89
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase B
Intraflagellar transport protein 20 homolog A
Differentially expressed in FDCP 6 homolog
ADP-ribosylation factor-like protein 6-interacting protein 4
Actin-related protein 2/3 complex subunit 1A-B
LysM and putative peptidoglycan-binding domain-containing protein 4
Cyclic AMP-responsive element-binding protein 3-like protein 2
Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Zinc finger TRAF-type-containing protein 1-B
Adenosine deaminase domain-containing protein 1
Transmembrane anterior posterior transformation protein 1 homolog
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Zinc finger and BTB domain-containing protein 18
Vacuolar protein-sorting-associated protein 36
Eukaryotic translation initiation factor 3 subunit C
Leucine-rich repeat and WD repeat-containing protein 1
Interferon regulatory factor 2-binding protein-like B
Src kinase-associated phosphoprotein 2-B
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Abolishes kinase activity inhibition during M-phase. Does not affect ability to phosphorylate cdk1.
Impairs without abolishing ability to phosphorylate cdk1.
Abolishes phosphorylation by GWL and ability to regulate mitosis.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Ubiquitin carboxyl-terminal hydrolase 44-A
Cytochrome b5 domain-containing protein 1
Not phosphorylated but normally recruited to chromatin and able to stimulate replication checkpoint signaling upon replication fork stalling; when associated with A-26 and A-32.
Not phosphorylated but normally recruited to chromatin and able to stimulate replication checkpoint signaling upon replication fork stalling; when associated with A-26 and A-36.
Not phosphorylated but normally recruited to chromatin and able to stimulate replication checkpoint signaling upon replication fork stalling; when associated with A-32 and A-36.
WD repeat domain phosphoinositide-interacting protein 1
Structural maintenance of chromosomes protein 6
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Interchain (between light and heavy chains)
Amiloride-sensitive sodium channel subunit gamma-2
Inositol 1,4,5-trisphosphate receptor-interacting protein
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Mitochondrial amidoxime-reducing component 1
Eukaryotic translation initiation factor 4E type 3-B
Barrier-to-autointegration factor-like protein
Coiled-coil domain-containing protein 124-B
Bactericidal permeability-increasing protein
Leucine-rich repeat-containing protein 69
Haloacid dehalogenase-like hydrolase domain-containing protein 3
Histone-arginine methyltransferase CARM1
SPRY domain-containing SOCS box protein 3
Calcium-binding and coiled-coil domain-containing protein 1-A
RNA polymerase-associated protein CTR9 homolog
Thioredoxin domain-containing protein 12
T-cell acute lymphocytic leukemia protein 1
D-box that targets the protein for proteasomal degradation in anaphase
Ubiquitin carboxyl-terminal hydrolase 12-A
POU domain, class 5, transcription factor 1.3
Mediator of RNA polymerase II transcription subunit 30
Actin-related protein 2/3 complex subunit 2-A
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Mitotic spindle assembly checkpoint protein MAD2B
Xenotropic and polytropic retrovirus receptor 1 homolog
Dominant negative that inhibits vangl2-B function.
TP53-regulated inhibitor of apoptosis 1-B
Histone-lysine N-methyltransferase KMT5B-A
Chromosome transmission fidelity protein 18 homolog
Mediator of RNA polymerase II transcription subunit 19
Phosphatidylinositol 3-kinase catalytic subunit type 3
Store-operated calcium entry-associated regulatory factor
Breast cancer anti-estrogen resistance protein 3 homolog
Transforming growth factor-beta-induced protein ig-h3
Disintegrin and metalloproteinase domain-containing protein 22
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
Prolyl-tRNA synthetase associated domain-containing protein 1
Leucine-rich repeat-containing G-protein coupled receptor 5A
Eukaryotic translation initiation factor 3 subunit I
Heterogeneous nuclear ribonucleoprotein D-like-B
Maternal DNA replication licensing factor mcm6
Reduces ATPase activity of the mcm2-mcm7 complex by 50% and disrupts DNA replication. Does not disrupt formation of the pre-replicative complex onto chromatin. Abolishes ATPase activity of the mcm2-mcm7 complex; when associated with A-386 in mcm7.
Putative gastrointestinal growth factor xP4
Myeloid differentiation primary response protein MyD88-A
Protein phosphatase 1 regulatory subunit 3B-A
tRNA N6-adenosine threonylcarbamoyltransferase
Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog
G-patch domain and KOW motifs-containing protein
RAC-beta serine/threonine-protein kinase B
Dual specificity mitogen-activated protein kinase kinase 1
Cysteine-rich DPF motif domain-containing protein 1
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Afadin- and alpha-actinin-binding protein B
ATPase family AAA domain-containing protein 3-A
Corticotropin-releasing factor-binding protein
Sister chromatid cohesion protein PDS5 homolog B-A
Important for regulated proteolytic degradation
Abolished ability to mediate ubiquitination of mcm7.
Does not affect ability to mediate ubiquitination of mcm7.
Impaired ability to mediate ubiquitination of mcm7. Abolished ability to promote ubiquitination of covalent DNA-protein cross-links (DPCs).
Mitochondrial inner membrane protease ATP23 homolog
Very-long-chain 3-oxoacyl-CoA reductase-B
Probable ATP-dependent RNA helicase DDX4
Myb/SANT-like DNA-binding domain-containing protein 3
Embryonic polyadenylate-binding protein 2-B
Protein prenyltransferase alpha subunit repeat-containing protein 1-A
Mannose-1-phosphate guanyltransferase beta-B
Serine/threonine-protein phosphatase 4 regulatory subunit 2-A
Sorting and assembly machinery component 50 homolog B
Abolishes transcriptional repressive activity towards GATA.
V(D)J recombination-activating protein 2
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
SHC SH2 domain-binding protein 1 homolog B
Microtubule-associated protein RP/EB family member 2
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Cyclin-dependent kinase 2-interacting protein
Peroxisome proliferator-activated receptor gamma
General transcription factor IIF subunit 1
Mediator of RNA polymerase II transcription subunit 9
Abolishes binding to 5'-ATTGTT-3' DNA sequence.
Abolishes binding to 5'-ATTGTT-3' DNA sequence. Does not affect ctnnb1-binding.
Abolishes binding to 5'-ATTGTT-3' DNA sequence. Reduces binding to the nodal5 promoter. Does not affect ctnnb1-binding.
Does not abolish binding to 5'-ATTGTT-3' DNA sequence.
NPC intracellular cholesterol transporter 2
von Willebrand factor A domain-containing protein 2
Actin-related protein 2/3 complex subunit 2-B
Nuclear receptor subfamily 2 group E member 1
Nuclear factor interleukin-3-regulated protein
Abolished ability to mediate peroxisomal import of proteins.
Abolished monoubiquitination, leading to impaired ability to mediate peroxisomal import of proteins.
Does not affect ability to mediate peroxisomal import of proteins.
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)
Strogly reduced ability to mediate peroxisomal import of proteins; when associated with 112-A--A-119.
Strogly reduced ability to mediate peroxisomal import of proteins; when associated with 132-A--A-136.
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Microtubule-associated serine/threonine-protein kinase 3
Cleavage and polyadenylation specificity factor subunit 4
Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A
Glutamine amidotransferase-like class 1 domain-containing protein 1
Lipid droplet-regulating VLDL assembly factor AUP1
CCR4-NOT transcription complex subunit 10-A
amyloid beta (A4) precursor-like protein 2 S homeolog isoform 2
Protein-S-isoprenylcysteine O-methyltransferase
Iroquois-class homeodomain protein irx-4-B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
N6-adenosine-methyltransferase non-catalytic subunit
Ciliogenesis and planar polarity effector 2
Loss of localization to the cilium basal body. Dominant negative form altering cilium biogenesis.
Mitochondrial import inner membrane translocase subunit tim16-B
Lysosomal cobalamin transport escort protein LMBD1
SKI8 subunit of superkiller complex protein
Abolishes chromatin binding. Abolishes DNA-binding activity in vitro.
Heterogeneous nuclear ribonucleoprotein C
Decreased phosphorylation by plk1/plx1; when associated with A-482 and A-486.
Decreased phosphorylation by plk1/plx1; when associated with A-482 and A-490.
Decreased phosphorylation by plk1/plx1; when associated with A-486 and A-490.
Histone-lysine N-methyltransferase SETDB1
Mediator of RNA polymerase II transcription subunit 27-A
Abolishes interaction with CLSPN and kinase activation during checkpoint signaling. No effect on phosphorylation at S-344.
Abolishes interaction with CLSPN, abrogates phosphorylation at S-344 and abolishes kinase activity.
Abolishes interaction with CLSPN. Abrogates phosphorylation at S-344 and kinase activation during checkpoint signaling.
Abolishes kinase activity; no effect on interaction with CLSPN.
Abrogates phosphorylation and activation during checkpoint signaling; when associated with A-314; A-344 and A-356.
Abrogates phosphorylation and activation during checkpoint signaling; when associated with A-314; A-344 and A-365.
Abrogates phosphorylation and activation during checkpoint signaling; when associated with A-314; A-356 and A-365.
Abrogates phosphorylation and activation during checkpoint signaling; when associated with A-344; A-356 and A-365.
Enhances kinase activity and abrogates nuclear localization.
Impairs autoinhibition and abrogates nuclear localization.
Impairs autoinhibition by the AIR domain; when associated with D-314; D-344 and D-356.
Impairs autoinhibition by the AIR domain; when associated with D-314; D-344 and D-365.
Impairs autoinhibition by the AIR domain; when associated with D-314; D-356 and D-365.
Impairs autoinhibition by the AIR domain; when associated with D-344; D-356 and D-365.
Impairs autoinhibition by the AIR domain; when associated with E-314; E-344 and E-356.
Impairs autoinhibition by the AIR domain; when associated with E-314; E-344 and E-365.
Impairs autoinhibition by the AIR domain; when associated with E-314; E-356 and E-365.
Impairs autoinhibition by the AIR domain; when associated with E-344; E-356 and E-365.
Induces hyperphosphorylation and enhances kinase activity and cell cycle arrest. Abolishes interaction with CLSPN.
Induces hyperphosphorylation and enhances kinase activity.
Actin-related protein 2/3 complex subunit 3-A
Trimeric intracellular cation channel type B-B
Mediator of RNA polymerase II transcription subunit 16
Intraflagellar transport protein 43 homolog
Glyceraldehyde-3-phosphate dehydrogenase
Cell division control protein 45 homolog
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Abrogates interaction with NCOR1 and transcriptional repression; when associated with N-33.
Abrogates interaction with NCOR1 and transcriptional repression; when associated with Q-47.
Translocon-associated protein subunit beta
Eukaryotic translation initiation factor 3 subunit G-B
Potassium voltage-gated channel subfamily KQT member 1
Pleckstrin homology domain-containing family J member 1
Transcription and mRNA export factor ENY2
Regulator of G-protein signaling 7-binding protein
Probable cysteine--tRNA ligase, mitochondrial
No effect on ubiquitination and degradation in response to calcium.
Prevents ubiquitination and degradation in response to calcium.
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Serine/threonine-protein kinase pdik1l-A
B-cell CLL/lymphoma 7 protein family member A
Disrupts DNA-binding. Unable to repress id3 transcription. Disrupts the ability to promote cell survival and up-regulate neural border genes. Does not disrupt the ability to promote cell proliferation and neural crest cell formation.
Complex I assembly factor TIMMDC1, mitochondrial
Calcium/calmodulin-dependent protein kinase type II delta chain
39S ribosomal protein L15, mitochondrial
Basic leucine zipper transcriptional factor ATF-like
Proto-oncogene tyrosine-protein kinase receptor Ret
Cleavage mutant which disrupts nodal signaling in a dominant negative-like manner when overexpressed. Remains secreted, retains some signaling activity and able to induce some mesoderm; when associated with 209-A--A-212.
Cleavage mutant which disrupts nodal signaling in a dominant negative-like manner when overexpressed. Remains secreted, retains some signaling activity and able to induce some mesoderm; when associated with 278-G--G-282.
Greatly reduces muscle actin inducing activity.
No effect on mesoderm-inducing activities.
Phytanoyl-CoA hydroxylase-interacting protein-like
Leucine-rich repeat and coiled-coil domain-containing protein 1
Actin-related protein 2/3 complex subunit 5-C
Vacuolar protein sorting-associated protein 26B-A
Developmentally-regulated GTP-binding protein 1
Does not affect the microtubule-related activities, including binding and tubulin polymerization.
Iron-responsive element-binding protein 2
'Ionic lock' involved in activated form stabilization
Near loss of rhodopsin accumulation in rod outer segments.
Mitochondrial import inner membrane translocase subunit Tim13-B
Nonsense-mediated mRNA decay factor SMG9
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Segment polarity protein dishevelled homolog DVL-3
Actin-related protein 2/3 complex subunit 4
Leucine-rich repeat-containing protein 14
AT-rich interactive domain-containing protein 3A
WLDD motif; essential for 7-methylguanosine-containing mRNA cap binding
Zinc finger CCCH domain-containing protein 15
Tumor necrosis factor alpha-induced protein 8-like protein 2
Arginine/serine-rich coiled-coil protein 2
Strongly impairs interaction with nuclear receptors.
Weakly impairs interaction with nuclear receptors.
Mediator of RNA polymerase II transcription subunit 7-A
Proline-, glutamic acid- and leucine-rich protein 1
Baculoviral IAP repeat-containing protein 5.1-A
Mimics phosphorylation but still inhibits spindle assembly.
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Pleckstrin homology-like domain family A member 2
Mitochondrial enolase superfamily member 1
Proline-rich nuclear receptor coactivator 2 B
T-cell surface glycoprotein CD3 zeta chain
Abolishes degradation by the proteasome due to the disrupted interaction with pcna.
Abolishes degradation by the proteasome without affecting the interaction with pcna.
Probable RNA polymerase II nuclear localization protein SLC7A6OS
N-alpha-acetyltransferase 38-B, NatC auxiliary subunit
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Transcription initiation factor TFIID subunit 8
Major facilitator superfamily domain-containing protein 6-like protein B
DNA replication ATP-dependent helicase/nuclease DNA2
Serine palmitoyltransferase small subunit A-B
POU domain, class 3, transcription factor 2-B
Mediator of RNA polymerase II transcription subunit 23
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Axin interactor, dorsalization-associated protein A
Mini-chromosome maintenance complex-binding protein
Betaine--homocysteine S-methyltransferase 1
Tectonin beta-propeller repeat-containing protein 1
Voltage-gated potassium channel subunit beta-2
Actin, cytoplasmic 1, N-terminally processed
N-acetylglutamate; in Actin, cytoplasmic 1, N-terminally processed
N-acetylmethionine; in Actin, cytoplasmic 1; alternate
Notch-regulated ankyrin repeat-containing protein
Mediator of RNA polymerase II transcription subunit 1
Target of rapamycin complex subunit lst8
Guanine nucleotide-binding protein subunit alpha-14
Phosphatidylinositol-glycan-specific phospholipase D
Cytosolic arginine sensor for mTORC1 subunit 2
KH domain-containing RNA-binding protein qki.S
Abolishes mRNA-binding and cytoplasmic retention, localizing predominantly to the nucleus from early development. Also disrupts DNA-binding; when associated with A-433.
Abolishes mRNA-binding and cytoplasmic retention, localizing predominantly to the nucleus from early development. Also disrupts DNA-binding; when associated with A-552.
Probable 39S ribosomal protein L24, mitochondrial
Echinoderm microtubule-associated protein-like 4
Calmodulin-regulated spectrin-associated protein 1
Heterogeneous nuclear ribonucleoprotein A3 homolog 1
Histone-lysine N-methyltransferase SETD1B
Translocon-associated protein subunit delta
signal sequence receptor, delta L homeolog
Phenylalanine--tRNA ligase alpha subunit B
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
Maternal DNA replication licensing factor mcm3
U4/U6 small nuclear ribonucleoprotein Prp31
Vacuolar protein sorting-associated protein 29
Inhibits its targeting to microtubule minus ends.
Long-chain-fatty-acid--CoA ligase ACSBG2
Fragile X messenger ribonucleoprotein 1 homolog A
Pentatricopeptide repeat-containing protein 2, mitochondrial
Polypeptide N-acetylgalactosaminyltransferase
Putative glutathione-specific gamma-glutamylcyclotransferase 2
Pancreatic progenitor cell differentiation and proliferation factor B
Insulin-like growth factor-binding protein 2
Zinc finger and BTB domain-containing protein 18.3
Glucose-fructose oxidoreductase domain-containing protein 2
Hormonally up-regulated neu tumor-associated kinase homolog A
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial
Myocyte-specific enhancer factor 2D homolog
Serine/threonine-protein phosphatase 4 regulatory subunit 3-B
Eukaryotic translation initiation factor 3 subunit D
Impairs the ability of the C-terminal fragment to block nuclear pore assembly.
Histone-lysine N-methyltransferase SUV39H1
Mitochondrial import inner membrane translocase subunit Tim10-B
CCR4-NOT transcription complex subunit 6-like-A
CBY1-interacting BAR domain-containing protein 1-B
Abolishes E3 activity but does not affect interaction with smad4; when associated with A-100.
Abolishes E3 activity but does not affect interaction with smad4; when associated with A-97.
O-linked (Xyl...) (heparan sulfate) serine
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Uncharacterized protein KIAA1143 homolog
Src kinase-associated phosphoprotein 2-A
Zinc finger CCCH-type with G patch domain-containing protein
Nascent polypeptide-associated complex subunit alpha
DNA replication complex GINS protein PSF1
Ubiquinone biosynthesis protein COQ9-A, mitochondrial
POU domain, class 2, transcription factor 3L
Secretory carrier-associated membrane protein 5B
Actin-related protein 2/3 complex subunit 3-B
Eukaryotic translation initiation factor 4E type 3-A
Protein arginine N-methyltransferase 1-B
Fibroblast growth factor receptor-like 1
Post-GPI attachment to proteins factor 2
Ubiquitin carboxyl-terminal hydrolase 44-B
Methylthioribulose-1-phosphate dehydratase
Nuclear nucleic acid-binding protein C1D
Mediator of RNA polymerase II transcription subunit 10
Peptidyl-glycine alpha-amidating monooxygenase A
TP53-regulated inhibitor of apoptosis 1-A
Hairy/enhancer-of-split related with YRPW motif protein 1
Ganglioside-induced differentiation-associated protein 2
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Calcium-binding mitochondrial carrier protein SCaMC-1-A
39S ribosomal protein L41-A, mitochondrial
Queuine tRNA-ribosyltransferase catalytic subunit 1
Mediator of RNA polymerase II transcription subunit 31-A
WD repeat domain phosphoinositide-interacting protein 4
Calcitonin gene-related peptide type 1 receptor
p21-activated protein kinase-interacting protein 1-like
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Eukaryotic translation initiation factor 3 subunit J
Nuclear envelope integral membrane protein 1a
Growth factor receptor-bound protein 2-A
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
Palmitoleoyl-protein carboxylesterase notum2
Receptor-type tyrosine-protein phosphatase alpha
protein tyrosine phosphatase, receptor type A S homeolog
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Myeloid differentiation primary response protein MyD88-B
Transcription initiation factor TFIID subunit 6
Parathyroid hormone/parathyroid hormone-related peptide receptor
POU domain, class 2, transcription factor 1
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-102; A-292; A-373; A-610; A-691; A-870; A-950; A-1250 and A-1335. Greatly impairs microtubule polymerase activity; when associated with A-102; A-292 and A-373.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-373; A-610; A-691; A-870; A-1250 and A-1335. Slightly impairs microtubule polymerase activity; when associated with A-610; A-691; A-870; A-1250 and A-1335.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-373; A-610; A-691; A-870; A-950 and A-1250. Slightly impairs microtubule polymerase activity; when associated with A-1250.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-373; A-610; A-691; A-870; A-950 and A-1335. Slightly impairs microtubule polymerase activity; when associated with A-1335.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-373; A-610; A-691; A-950; A-1250 and A-1335. Slightly impairs microtubule polymerase activity; when associated with A-610; A-691; A-950; A-1250 and A-1335.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-373; A-610; A-870; A-950; A-1250 and A-1335. Slightly impairs microtubule polymerase activity; when associated with A-610; A-870; A-950; A-1250 and A-1335.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-373; A-691; A-870; A-950; A-1250 and A-1335. Slightly impairs microtubule polymerase activity; when associated with A-691; A-870; A-950; A-1250 and A-1335.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-292; A-610; A-691; A-870; A-950; A-1250 and A-1335. Greatly impairs microtubule polymerase activity; when associated with A-21; A-102 and A-292.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-102; A-373; A-610; A-691; A-870; A-950; A-1250 and A-1335. Greatly impairs microtubule polymerase activity; when associated with A-21; A-102 and A-373.
Abolishes binding to tubulin and microtubule polymerase activity; when associated with A-21; A-292; A-373; A-610; A-691; A-870; A-950; A-1250 and A-1335. Greatly impairs microtubule polymerase activity; when associated with A-21; A-292 and A-373.
Disrupts interaction with tacc3; when associated with D-2054.
Disrupts interaction with tacc3; when associated with D-2061.
Disrupts interaction with tacc3; when associated with S-2053.
Disrupts interaction with tacc3; when associated with S-2060.
Does not reduce RNA-binding. Reduces strongly RNA-binding; when associated with L-194.
Reduces slightly RNA-binding. Reduces strongly RNA-binding; when associated with L-105.
Mediator of RNA polymerase II transcription subunit 20
WD repeat-containing and planar cell polarity effector protein fritz homolog
Myelin-associated neurite-outgrowth inhibitor
Ubiquitin-like modifier-activating enzyme 5
Guanine nucleotide-binding protein G(o) subunit alpha
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Does not affect protein expression in meiosis II; when associated with A-95. Does not affect protein expression in entered M phase; when associated with A-95. Mostly inhibits the degradation of cyclin B at the meiosis I exit, maintains cdk1 activity at a high level, and arrests meiosis I at metaphase; when associated with A-95.
Does not affect protein expression in meiosis II; when associated with A-99. Does not affect protein expression in entered M phase; when associated with A-99. Mostly inhibits the degradation of cyclin B at the meiosis I exit, maintains cdk1 activity at a high level, and arrests meiosis I at metaphase; when associated with A-99.
Does not inhibit APC; when associated with S-354.
Does not inhibit APC; when associated with S-356.
Not mitotically degraded; when associated with A-10; A-105; A-123 and A-328. Delays fbxo5 proteolysis. Does not affect pin1 interaction. Impairs pin1 interaction; when associated with A-10. Impairs pin1 interaction; when associated with A-10 and A-105. Impairs pin1 interaction; when associated with A-10; A-105 and A-123. Impairs pin1 interaction; when associated with A-10; A-105; A-123 and A-328.
Not mitotically degraded; when associated with A-10; A-29; A-105 and A-123. Does not affect fbxo5 proteolysis. Does not affect pin1 interaction. Impairs pin1 interaction; when associated with A-10; A-29; A-105 and A-123.
Not mitotically degraded; when associated with A-10; A-29; A-105 and A-328. Delays fbxo5 proteolysis. Does not affect pin1 interaction. Impairs pin1 interaction; when associated with A-10; A-29 and A-105. Impairs pin1 interaction; when associated with A-10; A-29; A-105 and A-328.
Not mitotically degraded; when associated with A-10; A-29; A-123 and A-328. Does not affect fbxo5 proteolysis. Does not affect pin1 interaction. Impairs pin1 interaction; when associated with A-10 and A-29. Impairs pin1 interaction; when associated with A-10; A-29 and A-123. Impairs pin1 interaction; when associated with A-10; A-29; A-123 and A-328.
Not mitotically degraded; when associated with A-29; A-105; A-123 and A-328. Does not affect fbxo5 proteolysis. Impairs pin1 interaction. Impairs pin1 interaction; when associated with A-29. Impairs pin1 interaction; when associated with A-29 and A-105. Impairs pin1 interaction; when associated with A-29; A-105 and A-123. Impairs pin1 interaction; when associated with A-29; A-105; A-123 and A-328. Proteolysated in the presence of Pin1. Degraded at G2 phase.
Reduces regulated proteolytic degradation.
Sodium-coupled monocarboxylate transporter 1
Nuclear distribution protein nudE homolog 1-B
MDS1 and EVI1 complex locus protein EVI1-A
Biogenesis of lysosome-related organelles complex 1 subunit 5
Afadin- and alpha-actinin-binding protein A
5-glutamyl coenzyme A thioester intermediate
BTB/POZ domain-containing protein kctd15
Coiled-coil domain-containing protein 77
SANT and BTB domain regulator of class switch recombination
Protein phosphatase 1 regulatory subunit 3B-B
Immunoglobulin-like domain-containing receptor 1
Translocating chain-associated membrane protein 1-like 1
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Loss of function due to disruption of the EDM complex.
Dimethyladenosine transferase 1, mitochondrial
reversibly protonated residue during proton transport
General transcription factor IIF subunit 2
RNA cytosine-C(5)-methyltransferase NSUN2
Transcription initiation factor TFIID subunit 12
Double-strand break repair protein MRE11
Nuclear receptor subfamily 6 group A member 1
U3 small nucleolar RNA-associated protein 15 homolog
Zona pellucida-like domain-containing protein 1
Zona pellucida-like domain-containing protein 1, secreted form
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 homolog
Glutamate receptor-interacting protein 2
Protein transport protein Sec61 subunit gamma
Probable E3 ubiquitin-protein ligase makorin-1
SHC SH2 domain-binding protein 1 homolog A
Mitochondrial import inner membrane translocase subunit Tim21
Beta-1,4 N-acetylgalactosaminyltransferase
HUWE1-associated protein modifying stress responses
Sodium-dependent phosphate transporter 1-B
Transforming growth factor beta-2 proprotein
Abolishes DNA-binding and disrupts function.
Abolishes mesoderm inducing activity and interaction with tle4.
Reduces mesoderm-inducing activity; when associated with A-140.
Reduces mesoderm-inducing activity; when associated with A-144.
Myocyte-specific enhancer factor 2A homolog
Significantly reduces phosphorylation by NLK. Further reduces phosphorylation by NLK; when associated with A-343.
Significantly reduces phosphorylation by NLK. Further reduces phosphorylation by NLK; when associated with A-386.
Serine/threonine-protein phosphatase 4 regulatory subunit 2-B
Biorientation of chromosomes in cell division protein 1
Sodium/potassium-transporting ATPase subunit alpha-1
Vesicular, overexpressed in cancer, prosurvival protein 1
CCR4-NOT transcription complex subunit 10-B
3-hydroxy-3-methylglutaryl-coenzyme A reductase
TRAF-interacting protein with FHA domain-containing protein A
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit A
Retroviral integration site protein Fli-1 homolog
39S ribosomal protein L51, mitochondrial
Cleavage and polyadenylation specificity factor subunit 6
non-specific serine/threonine protein kinase
NF-kappa-B inhibitor-interacting Ras-like protein 2
Abolishes serine/threonine-protein kinase activity and ability to regulate mitosis.
Abolishes the ability to regulate M phase.
Serine/threonine-protein kinase greatwall
Thiazolidine linkage to a ring-opened DNA abasic site
High-affinity lysophosphatidic acid receptor
Lacks kinase activity. Disrupts mitotic spindle assembly.
Polyadenylate-binding protein-interacting protein 1
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
Eukaryotic translation initiation factor 4E
Acyl-CoA-binding domain-containing protein 5
Reduction in activity and altered substrate specificity; inactive towards 4-nitroquinoline-1-oxide, active towards ethacrynic acid and tPBO.
Fumarylacetoacetate hydrolase domain-containing protein 2
G-protein coupled receptor-associated protein LMBRD2
Rap1 GTPase-GDP dissociation stimulator 1-B
Actin filament-associated protein 1-like 2
Centrosomal protein of 170 kDa protein B
Iroquois-class homeodomain protein irx-5
Trimeric intracellular cation channel type B-A
Gamma-aminobutyric acid receptor-associated protein-like 1
Phosphatidylethanolamine amidated glycine
Glycosyltransferase 8 domain-containing protein 1
Insulin-like growth factor-binding protein 1
FAST kinase domain-containing protein 1, mitochondrial
Histone-lysine N-methyltransferase SETDB2
Doublesex- and mab-3-related transcription factor 1A
Putative gastrointestinal growth factor xP1
Abolishes DNA-binding activity and reduces ability to inhibit mesoderm formation; when associated with C-199 and E-241.
Abolishes DNA-binding activity and reduces ability to inhibit mesoderm formation; when associated with D-195 and C-199.
Abolishes DNA-binding activity and reduces ability to inhibit mesoderm formation; when associated with D-195 and E-241.
Eukaryotic translation initiation factor 3 subunit G-A
Growth factor receptor-bound protein 2-B
Uncharacterized protein C16orf52 homolog B
GTP cyclohydrolase 1 feedback regulatory protein
Methenyltetrahydrofolate synthase domain-containing protein
CXXC motif containing zinc binding protein
Ubiquitin carboxyl-terminal hydrolase 10-B
Short-chain dehydrogenase/reductase family 42E member 1
CDGSH iron-sulfur domain-containing protein 2B
SH3 domain-binding glutamic acid-rich-like protein 2-A
GTPase-activating protein and VPS9 domain-containing protein 1
Leucine-rich repeat flightless-interacting protein 2
Regulator of G-protein signaling 9-binding protein C
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Leukocyte receptor cluster member 8 homolog
Leucine-rich repeat transmembrane protein FLRT3
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
Vesicular inhibitory amino acid transporter
Doublesex- and mab-3-related transcription factor DM-W
EF-hand calcium-binding domain-containing protein 7
SH3 and multiple ankyrin repeat domains protein 2
EGF domain-specific O-linked N-acetylglucosamine transferase
Actin-related protein 2/3 complex subunit 5-B
Pancreatic progenitor cell differentiation and proliferation factor A
Retains neural-inducing activity but at reduced potency.
Single-strand selective monofunctional uracil DNA glycosylase
Mediator of RNA polymerase II transcription subunit 7-B
CDK-activating kinase assembly factor MAT1
Translationally-controlled tumor protein homolog
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Myeloid-associated differentiation marker homolog
Eukaryotic translation initiation factor 2 subunit 1
Non-structural maintenance of chromosomes element 1 homolog
GATA zinc finger domain-containing protein 1
Mitochondrial coenzyme A transporter SLC25A42
FAD-dependent oxidoreductase domain-containing protein 1
Does not undergo cleavage and is not secreted. When overexpressed, acts as a dominant negative to disrupt derriere function, nodal signaling, processing and secretion of other TGF-beta members, posterior development and left-right asymmetry. Completely inhibits mesoderm formation.
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
LIM and calponin homology domains-containing protein 1
Alpha/beta hydrolase domain-containing protein 17B
Eliminates one of two sumoylated products.
Eliminates one of two sumoylated products. Abolishes interaction with sumoylation factors.
GDP-fucose protein O-fucosyltransferase 2
Nuclear receptor subfamily 2 group C member 1-B
Vacuolar protein sorting-associated protein 26B-B
Pre-miRNA 5'-monophosphate methyltransferase
39S ribosomal protein L45, mitochondrial
Heart- and neural crest derivatives-expressed protein 1