Radical S-adenosyl methionine domain-containing protein 2
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
In hrpti245; abnormal bumpy head accompanied by a shortened body axis of the embryo. During embryonic development, mutants are slightly smaller and show little or no growth thereafter. Induces rereplication and mitosis cessation.
In hrpx1; recesive allele that is lethal and induces a reduction of neurons number but with an increase of size. Induces rereplication and mitosis cessation.
In hrpx1; recessive allele that is lethal and induces a reduction of neurons number but with an increase of size. Induces rereplication and mitosis cessation.
Phosphatidate cytidylyltransferase, mitochondrial
Cytoplasmic polyadenylation element-binding protein 4
Tuberoinfundibular peptide of 39 residues
Kelch repeat and BTB domain-containing protein 12
DNA-directed RNA polymerase I subunit RPA43
Ankyrin repeat domain-containing protein 13C
Cyclic AMP-responsive element-binding protein 3-like protein 3-A
Helical; Signal-anchor for type II membrane protein
Processed cyclic AMP-responsive element-binding protein 3-like protein 3-A
tRNA modification GTPase GTPBP3, mitochondrial
receptor protein serine/threonine kinase
Cytoplasmic dynein 2 light intermediate chain 1
Leucine-rich repeat-containing protein 42
Translocon-associated protein subunit alpha
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
dolichyl-phosphate-mannose--protein mannosyltransferase
Zinc finger SWIM domain-containing protein 7
Leucine-rich repeat-containing protein 14B
Major facilitator superfamily domain-containing protein 4A
HUWE1-associated protein modifying stress responses
NK1 transcription factor-related protein 1
Cotranscriptional regulator FAM172A homolog
Pleckstrin homology-like domain family A member 3
SET and MYND domain-containing protein 4
Mitochondrial proton/calcium exchanger protein
Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein
In ty30b; curly tail phenotype and impaired left-right patterning.
Maternal embryonic leucine zipper kinase
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Acid sphingomyelinase-like phosphodiesterase
Pseudouridylate synthase RPUSD4, mitochondrial
D-ribitol-5-phosphate cytidylyltransferase
Very-long-chain 3-oxoacyl-CoA reductase-A
Endoplasmic reticulum junction formation protein lunapark-A
NAD(P)(+)--arginine ADP-ribosyltransferase
Platelet-derived growth factor receptor alpha
Mitochondrial tRNA-specific 2-thiouridylase 1
Notch-regulated ankyrin repeat-containing protein A
V-set and immunoglobulin domain-containing protein 10
Steroid 17-alpha-hydroxylase/17,20 lyase
Gly-cisPro motif, important for rejection of L-amino acids
FAD-dependent oxidoreductase domain-containing protein 2
Ras-specific guanine nucleotide-releasing factor RalGPS1
Trichoplein keratin filament-binding protein
Doublesex- and mab-3-related transcription factor 1
Methenyltetrahydrofolate synthase domain-containing protein
Mitochondrial coenzyme A transporter SLC25A42
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ubiquitin carboxyl-terminal hydrolase MINDY-1
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Cilia- and flagella-associated protein 299
Retinoic acid receptor responder protein 2
Eukaryotic translation initiation factor 3 subunit H-B
fibroblast growth factor receptor-like 1b
Loss of deoxyribonuclease and DNA decatenation activity.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Inactive hydroxysteroid dehydrogenase-like protein 1
For poly [ADP-ribose] polymerase activity
Cyclic AMP-dependent transcription factor ATF-4
Regulator of G-protein signaling 7-binding protein A
Hematopoietically-expressed homeobox protein hhex
Intraflagellar transport protein 22 homolog
Insulin-like growth factor-binding protein 1
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Trafficking protein particle complex subunit 6b
Does not rescue developmental defects in sa2206 mutants.
In sa2206; homozygous mutant fishes have reduced head and eye size, dysmorphic jaw, lack of pharyngeal arches, flat head without protruding mouth, downward curvature of the anterior-posterior axis, aplastic swim bladder, impaired locomotor behavior and neuromuscular junction defects.
O-linked (Xyl...) (heparan sulfate) serine
Calcium-binding mitochondrial carrier protein SCaMC-2-B
von Willebrand factor A domain-containing protein 1
Thioredoxin domain-containing protein 17
Reticulon-4-interacting protein 1 homolog, mitochondrial
Ubiquitin carboxyl-terminal hydrolase 44
Cystic fibrosis transmembrane conductance regulator
In pd1048; abolishes trafficking to the cell membrane and leads to severe reduction of the size of the Kupffer's vesicle.
GATA zinc finger domain-containing protein 1
CCR4-NOT transcription complex subunit 11
KH domain-containing, RNA-binding, signal transduction-associated protein 2
Zinc finger C4H2 domain-containing protein
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Solute carrier family 52, riboflavin transporter, member 3-B
Vacuolar protein sorting-associated protein 29
Zinc finger TRAF-type-containing protein 1
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial
Ubiquinol-cytochrome-c reductase complex assembly factor 2
Proton acceptor; for processing activity
Schiff-base intermediate with substrate; via pyruvic acid
Probable E3 ubiquitin-protein ligase makorin-1
Sodium-coupled monocarboxylate transporter 1
Histone deacetylase complex subunit SAP30L
Transmembrane protein with metallophosphoesterase domain
Myosin, light chain 1, alkali; skeletal, fast
Nuclear envelope phosphatase-regulatory subunit 1
Zinc finger CCCH domain-containing protein 18
Leucine-rich repeat-containing protein 3B
Eukaryotic translation initiation factor 3 subunit E-A
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Oxidoreductase NAD-binding domain-containing protein 1
Non-phosphorylatable mutant; localizes only in nucleus and is unable to localize in cytoplasm.
Mediator of RNA polymerase II transcription subunit 19-A
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Glycine amidinotransferase, mitochondrial
39S ribosomal protein L51, mitochondrial
Lateral signaling target protein 2 homolog
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Tumor necrosis factor receptor type 1-associated DEATH domain protein
(Microbial infection) O-linked (GlcNAc) tyrosine; by Yersinia Afp18
Protein arginine N-methyltransferase 8-B
Pancreatic progenitor cell differentiation and proliferation factor A
Guided entry of tail-anchored proteins factor 1
Phosphatidylserine amidated glycine; alternate
Epithelial splicing regulatory protein 1
Serine/threonine-protein phosphatase CPPED1
tRNA N(3)-methylcytidine methyltransferase METTL2
Melanocortin-2 receptor accessory protein 2A
In no food for thought mutant (nft); lethality caused by the absence of most of the intracerebral central arteries. Defects are caused by impaired Wnt signaling.
Reversion-inducing cysteine-rich protein with Kazal motifs
Methylthioribulose-1-phosphate dehydratase
Nucleoside diphosphate-linked moiety X motif 17
Acyl-CoA-binding domain-containing protein 5A
N6-(2-hydroxyisobutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Suppressor of tumorigenicity 7 protein homolog
Arginine/serine-rich coiled-coil protein 2
Processed sterol regulatory element-binding protein 2
Sterol regulatory element-binding protein 2
Probable UDP-sugar transporter protein SLC35A5
Mediator of RNA polymerase II transcription subunit 30
Probable vesicular acetylcholine transporter-A
Ubiquitin carboxyl-terminal hydrolase 46
Nuclear receptor subfamily 2 group F member 5
DNA-directed RNA polymerase III subunit RPC3
Ubiquitin carboxyl-terminal hydrolase 45
Eukaryotic translation initiation factor 6
Outer dynein arm-docking complex subunit 4
Mediator of RNA polymerase II transcription subunit 26
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
Symmetric dimethylarginine; by PRMT5; alternate
Ubiquitin carboxyl-terminal hydrolase 13
Tartrate-resistant acid phosphatase type 5
Inactive palmitoleoyl-protein carboxylesterase notum1b
2-aminomuconic semialdehyde dehydrogenase
Homozygous mutant embryos show abnormal innervation of the sensory epithelia.
Cysteine sulfinic acid (-SO2H); alternate
Hairy/enhancer-of-split related with YRPW motif protein 1
Histone-lysine N-methyltransferase SETD7
POU domain, class 5, transcription factor 1
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
WW domain-containing adapter protein with coiled-coil
Spliceosome-associated protein CWC27 homolog
Thioredoxin-related transmembrane protein 2-B
NEDD8-activating enzyme E1 regulatory subunit
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Protein phosphatase 1 regulatory subunit 42
Aspartate aminotransferase, mitochondrial
Coiled-coil domain-containing protein 80
Putative RNA polymerase II subunit B1 CTD phosphatase rpap2
Activity-dependent neuroprotective protein 2a
Translocon-associated protein subunit delta
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Polypeptide N-acetylgalactosaminyltransferase
Serine/threonine-protein kinase SIK3 homolog
Transmembrane anterior posterior transformation protein 1 homolog
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Vascular endothelial growth factor receptor 2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
Cyclin-D-binding Myb-like transcription factor 1
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Lysophosphatidylcholine acyltransferase 1
Neurogenic locus notch homolog protein 1
Vacuolar protein sorting-associated protein 26A
Mitochondrial import inner membrane translocase subunit Tim10
BRCA2-interacting transcriptional repressor EMSY
Sperm-tail PG-rich repeat-containing protein 2
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
Serine/threonine-protein phosphatase 4 catalytic subunit B
Pancreas transcription factor 1 subunit alpha
von Willebrand factor A domain-containing protein 8
Chromodomain-helicase-DNA-binding protein 1-like
28S ribosomal protein S15, mitochondrial
Katanin p60 ATPase-containing subunit A-like 1
Speckle targeted PIP5K1A-regulated poly(A) polymerase
Sorting and assembly machinery component 50 homolog A
Myeloid differentiation primary response protein MyD88
Calcium/calmodulin-dependent protein kinase type II delta 1 chain
Helical; Anchor for type IV membrane protein
5-glutamyl coenzyme A thioester intermediate
NF-kappa-B inhibitor-interacting Ras-like protein 1
Mediator of RNA polymerase II transcription subunit 4
T-cell leukemia translocation-altered gene protein homolog
Eukaryotic translation initiation factor 2 subunit 3
Abolishes repression of nfe2l2/nrf2-dependent gene expression.
N6-adenosine-methyltransferase non-catalytic subunit
Schiff-base intermediate with acetaldehyde
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
Mediator of RNA polymerase II transcription subunit 13-like
Vacuolar protein sorting-associated protein 41 homolog
Oxidized purine nucleoside triphosphate hydrolase
Signal peptide, CUB and EGF-like domain-containing protein 2
Myelin-associated neurite-outgrowth inhibitor
Probable glutamate--tRNA ligase, mitochondrial
Abolished binding to N6-methyladenosine (m6A)-containing RNAs; when associated to A-445 and A-499.
Abolished binding to N6-methyladenosine (m6A)-containing RNAs; when associated to A-445 and A-504.
Abolished binding to N6-methyladenosine (m6A)-containing RNAs; when associated to A-499 and A-504.
Mediator of RNA polymerase II transcription subunit 18
EF-hand calcium-binding domain-containing protein 11
Mitochondrial import receptor subunit TOM20 homolog B
28-fold decrease in affinity for histone H3.
Reduced binding to histone H3. Reduced binding to histone H3; when associated with M-378.
Reduced binding to histone H3; when associated with M-386.
Minor effect in protein transduction efficiency.
Reduced protein transduction efficiency. Loss of transduction ability; when associated with A-7.
Reduced protein transduction efficiency. Loss of transduction ability; when associated with Q-21.
Reduced protein transduction efficiency. Loss of transduction ability; when associated with Q-23.
Reduced protein transduction efficiency. Loss of transduction ability; when associated with Q-9.
Abolishes catalytic activity. No effect on nuclear localization.
Fails to localize to the nucleus. No effect on catalytic activity.
N-acylneuraminate cytidylyltransferase A
Coiled-coil domain-containing protein 153
Cilia- and flagella-associated protein 298
In tm304; temperature sensitive allele with strongest phenotypes at 32 degrees Celsius and milder phenotypes at 25 degrees Celsius. Body curvature defects and kidney cysts are seen in larval stages. Left-right asymmetry is abnormal with reversed or random positioning of heart, liver and pancreas. Males are infertile. Cilium length and number are unaffected. Initiation of cilium motility is impaired, and cilium outer dynein arms are absent. Cilium polarity is disorganized.
Mitochondrial outer membrane protein SLC25A46
Carnitine O-palmitoyltransferase 2, mitochondrial
Macrophage colony-stimulating factor 1 receptor
Zinc finger and BTB domain-containing protein 18
Nuclear nucleic acid-binding protein C1D
Major facilitator superfamily domain-containing protein 8
Ribosome-releasing factor 2, mitochondrial
Pre-miRNA 5'-monophosphate methyltransferase
Reduces activity to 3%. Causes the formation of a constitutive dimer in solution.
Proto-oncogene tyrosine-protein kinase receptor Ret
Capping protein inhibiting regulator of actin dynamics
KN motif and ankyrin repeat domain-containing protein 2
Dehydrogenase/reductase SDR family member 7B
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Trimeric intracellular cation channel type A
Eukaryotic translation initiation factor 4E-1B
Calcitonin gene-related peptide type 1 receptor
Protein N-terminal glutamine amidohydrolase
Protein phosphatase 1 regulatory subunit 35
LysM and putative peptidoglycan-binding domain-containing protein 3
Nitric oxide synthase-interacting protein
In st78; gross morphology is normal. Expression of myelin basic protein (mbp) in the central nervous system (CNS) is strongly reduced, whereas mbp expression in the peripheral nervous system is unaffected. Expression of sox10 and olig2 in oligodendrocyte precursor cells (OPCs) is significantly reduced. Migration of OPCs is impaired with delayed onset and aberrant pathfinding behavior. Myelination in the CNS is reduced at 5 and 9 days post-fertilization. Double knockouts with notch3 have a more severe phenotype.
Melanocortin-2 receptor accessory protein 2B
Confers ability to induce ectopic expression of isl1.
Does not confer ability to induce ectopic expression of isl1.
Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog
Aryl hydrocarbon receptor nuclear translocator 2
Cholesterol 25-hydroxylase-like protein 1, member 1
Ubiquitin carboxyl-terminal hydrolase 37
Ciliogenesis and planar polarity effector 2
CCR4-NOT transcription complex subunit 6-like
Gamma-aminobutyric acid receptor subunit alpha-1
Corticotropin-releasing factor-binding protein
Aspartate dehydrogenase domain-containing protein
Squamous cell carcinoma antigen recognized by T-cells 3
Eukaryotic translation initiation factor 4E-binding protein 3-like
Transcription elongation factor, mitochondrial
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Nonsense-mediated mRNA decay factor SMG5
Solute carrier family 2, facilitated glucose transporter member 10
Sodium channel protein type 4 subunit alpha B
Overexpressed in colon carcinoma 1 protein homolog
Guanine nucleotide-binding protein subunit beta-5a
Armadillo-like helical domain-containing protein 3
Ubiquitin-fold modifier-conjugating enzyme 1
U4/U6 small nuclear ribonucleoprotein Prp31
NEDD8-activating enzyme E1 catalytic subunit
POU domain, class 3, transcription factor 2
Isoglutamyl cysteine thioester (Cys-Gln)
Mediator of RNA polymerase II transcription subunit 23
LysM and putative peptidoglycan-binding domain-containing protein 4
Wilms tumor protein 1-interacting protein homolog
Histone-lysine N-trimethyltransferase SMYD5
GTPase-activating Rap/Ran-GAP domain-like protein 3
Protein-glucosylgalactosylhydroxylysine glucosidase
Abolishes function in hematopoietic development; when associated with L-166.
Abolishes function in hematopoietic development; when associated with R-165.
Zinc finger CCCH-type with G patch domain-containing protein
Eukaryotic translation initiation factor 3 subunit J-B
N-alpha-acetyltransferase 38, NatC auxiliary subunit
Organic solute transporter subunit alpha
Receptor-type tyrosine-protein phosphatase F
Serine/threonine-protein kinase receptor
Uncharacterized protein C18orf19 homolog A
NACHT, LRR and PYD domains-containing protein 1 homolog
NACHT, LRR and PYD domains-containing protein 1, C-terminus
NACHT, LRR and PYD domains-containing protein 1, N-terminus
Aldo-keto reductase family 1 member A1-A
tRNA selenocysteine 1-associated protein 1
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) A
In LIK mutant; causes embryonic cardiac hyperplasia.
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Mothers against decapentaplegic homolog 2
Tumor necrosis factor alpha-induced protein 8-like protein 1
N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2
Tetratricopeptide repeat protein 19, mitochondrial
Leucine-rich repeat-containing protein 59
Phosphatidylinositol 4-kinase type 2-alpha
Guanine nucleotide-binding protein subunit beta-5b
In grns608; defective in early myocardial specification.
In hmp; leads to vertebral ankylosis; when associated with H-453.
In hmp; leads to vertebral ankylosis; when associated with N-556.
Mediator of RNA polymerase II transcription subunit 10
Insulin-like growth factor-binding protein 2-A
Unique cartilage matrix-associated protein
Unique cartilage matrix-associated protein C-terminal fragment
Ubiquitin-like domain-containing CTD phosphatase 1
Adenylyltransferase and sulfurtransferase MOCS3
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Breast cancer metastasis-suppressor 1-like protein-A
DNA-directed RNA polymerases I and III subunit RPAC2
RNA N6-adenosine-methyltransferase mettl16
Mitochondrial inner membrane protease subunit 2
Steroidogenic acute regulatory protein, mitochondrial
Eukaryotic translation initiation factor 3 subunit K
Rab3 GTPase-activating protein catalytic subunit
Very-long-chain 3-oxoacyl-CoA reductase-B
Notch-regulated ankyrin repeat-containing protein B
Replication protein A 70 kDa DNA-binding subunit
Cytochrome c oxidase assembly protein COX20, mitochondrial
Hepatoma-derived growth factor-related protein 2
Ubiquitin carboxyl-terminal hydrolase MINDY-3
DNA repair and recombination protein RAD54-like
GTP cyclohydrolase 1 feedback regulatory protein
Glucose-induced degradation protein 8-B homolog
H/ACA ribonucleoprotein complex subunit 2-like protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
WD repeat and coiled-coil-containing protein
In c14; gain-of-function mutation. Homozygous lethal, with no survival beyond 5 days post-fertilization (dpf). At 3 dpf, embryos show a range of developmental defects including a shortened and curved body axis, pericardial edema, malformed fin folds and a poorly developed jaw. Heterozygous adults have a fin overgrowth phenotype characterized by increased segment number. In addition, animals develop marked hyperossification of the axial skeleton. At two weeks of age, there is increased expression of genes involved in skeletal development including col2a1, col10a1 and osx.
Coiled-coil domain-containing protein 32
Influenza virus NS1A-binding protein homolog A
Glyceraldehyde-3-phosphate dehydrogenase 2
Outer mitochondrial transmembrane helix translocase
Gly-transPro motif, allows the protein to recognize chirality of D-amino acids
Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Regulator of G-protein signaling 7-binding protein B
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Adipocyte plasma membrane-associated protein
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A
Ankyrin repeat domain-containing protein 54
Major facilitator superfamily domain-containing protein 6-A
Abolishes catalytic activity. Abolishes pyroptosis induced by bacterial lipopolysaccharides (LPS).
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
S-adenosylmethionine mitochondrial carrier protein
Coiled-coil domain-containing protein 149-A
Eukaryotic translation initiation factor 2A
Exocyst complex component 3-like protein
Nascent polypeptide-associated complex subunit alpha
Cysteine-rich with EGF-like domain protein 2
Ribonucleoside-diphosphate reductase subunit M2
Ras-GEF domain-containing family member 1B-B
Reduces uroporphyrinogen decarboxylase activity.
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Putative sodium-coupled neutral amino acid transporter 11
Coiled-coil domain-containing protein 113
Vacuolar protein-sorting-associated protein 36
Calcium-binding mitochondrial carrier protein SCaMC-2-A
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Thioredoxin reductase-like selenoprotein T1a
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B
Protein phosphatase 1 regulatory subunit 21
Cysteine-rich DPF motif domain-containing protein 1
FXYD domain-containing ion transport regulator
Gamma-interferon-inducible lysosomal thiol reductase
Single-stranded DNA-binding protein, mitochondrial
Proprotein convertase subtilisin/kexin type 9
ADP-ribosylation factor-like protein 6-interacting protein 4
RAB7A-interacting MON1-CCZ1 complex subunit 1
Cilia- and flagella-associated protein 77
Betaine--homocysteine S-methyltransferase 1
Pleckstrin homology domain-containing family O member 1-A
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
Zinc finger and BTB domain-containing protein 16-A
Dynamin-like 120 kDa protein, mitochondrial
Pancreatic progenitor cell differentiation and proliferation factor B
Affects substrate specificity, diminishing N(8)-acetyl-spermidine deacetylase activity by 20-fold and enhancing acetyl-lysine deacetylase activity by about 100-fold.
No effect on steady-state kinetic parameters.
Probable phospholipid-transporting ATPase IIB
Mediator of RNA polymerase II transcription subunit 19-B
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
Post-GPI attachment to proteins factor 2
Parathyroid hormone/parathyroid hormone-related peptide receptor
Spermatogenesis-defective protein 39 homolog
Pleckstrin homology domain-containing family J member 1
BMP and activin membrane-bound inhibitor homolog
Eukaryotic translation initiation factor 3 subunit G
In hu2087; males develop normally and are fertile but females are sterile due to defects in meiosis.
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
EF-hand calcium-binding domain-containing protein 4A
Guanine nucleotide exchange protein smcr8a
Queuine tRNA-ribosyltransferase catalytic subunit 1
Probable cytosolic iron-sulfur protein assembly protein ciao1
G-protein coupled receptor-associated protein LMBRD2B
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Inosine-5'-monophosphate dehydrogenase 1a
Abolishes carbohydrate binding. Fails to homodimerize but can form higher-order oligomers; when associated with A-171; A-190; A-192 and A-246.
Fails to homodimerize but can form higher-order oligomers; when associated with A-135; A-171; A-190 and A-192.
Fails to homodimerize but can form higher-order oligomers; when associated with A-135; A-171; A-190 and A-246.
Fails to homodimerize but can form higher-order oligomers; when associated with A-135; A-171; A-192 and A-246.
Fails to homodimerize but can form higher-order oligomers; when associated with A-135; A-190; A-192 and A-246.
Suppressor of tumorigenicity 7 protein-like
Phosphatidylinositol-3-phosphatase SAC1-A
Serine/threonine-protein kinase 3 20kDa subunit
Serine/threonine-protein kinase 3 36kDa subunit
In zp1; temperature-sensitive mutation that blocks fin regeneration at the restrictive temperature.
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
rRNA N6-adenosine-methyltransferase METTL5
Acyl-CoA-binding domain-containing protein 5-B
Interferon-induced GTP-binding protein MxE
Abolishes nuclear localization and beta-catenin (ctnnb1) import into the nucleus.
Corticotropin-releasing factor receptor 1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Cerebellar degeneration-related protein 2-like
Transmembrane protein adipocyte-associated 1 homolog
2-oxoadipate dehydrogenase complex component E1
Chromatin modification-related protein MEAF6
Sprouty-related, EVH1 domain-containing protein 2
CARD- and ANK-domain containing inflammasome adapter protein
Inositol 1,4,5-trisphosphate receptor-interacting protein
Translationally-controlled tumor protein homolog
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
WD repeat domain phosphoinositide-interacting protein 4
Protein adenylyltransferase SelO-1, mitochondrial
In ko157; displays cardia bifida (2 hearts).
Sphingosine-1-phosphate transporter SPNS2
SKI family transcriptional corepressor 1 homolog-B
Hydroxysteroid 11-beta-dehydrogenase 1-like protein
Transcription and mRNA export factor ENY2
Presenilins-associated rhomboid-like protein, mitochondrial
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
tRNA 4-demethylwyosine synthase (AdoMet-dependent)
Mediator of RNA polymerase II transcription subunit 7
DNA damage-inducible transcript 4 protein
Inositol 1,4,5-triphosphate receptor associated 2
39S ribosomal protein L23, mitochondrial
Putative glutathione-specific gamma-glutamylcyclotransferase 2
Strongly reduced methyltransferase activity.
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Sodium-dependent lysophosphatidylcholine symporter 1-B
Severely impairs sphingomyelinase activity. No effect on mitochondrial localization.
Actin, cytoplasmic 1, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed
N-acetylmethionine; in Actin, cytoplasmic 1; alternate
Alpha/beta hydrolase domain-containing protein 17C
FHF complex subunit HOOK interacting protein 2B
Glycerophosphocholine cholinephosphodiesterase ENPP6
glycerophosphocholine cholinephosphodiesterase
Nuclear receptor subfamily 2 group F member 1-B
Telomere length regulation protein TEL2 homolog
4-trimethylaminobutyraldehyde dehydrogenase A
Xin actin-binding repeat-containing protein 1
LHFPL tetraspan subfamily member 3 protein
Calcium permeable stress-gated cation channel 1
Phosphatidylinositol 4-kinase type 2-beta
Collagen and calcium-binding EGF domain-containing protein 1
In fof(hu3613); lacks the thoracic duct and the previously unidentified intersegmental (ISLVs) and dorsal longitudinal lymphatic vessels (DLLVs) but retains a seemingly normal blood vasculature. Mutants show edema, initiating in the lower intestine and around the eyes from 6 dpf. At 36 dpf, surviving mutants show severe edema.
Ras-GEF domain-containing family member 1B-A
Probable E3 ubiquitin-protein ligase RNF144A-A
Ankyrin repeat domain-containing protein 45
Putative lipoyltransferase 2, mitochondrial
GDP-fucose protein O-fucosyltransferase 1
Ubiquitin carboxyl-terminal hydrolase 16
Protein phosphatase 1 regulatory subunit 7
Glial cell line-derived neurotrophic factor
POU domain, class 6, transcription factor 1
Neuronal PAS domain-containing protein 4B
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Increases arginine transport. Deacreases affinity for arginine; when associated with W-77 and W-81.
Increases arginine transport. Deacreases affinity for arginine; when associated with W-77and F-87.
Increases arginine transport. Deacreases affinity for arginine; when associated with W-81 and F-87.
Loss of L-arginine-enhanced L-leucine transport; when associated with A-79; A-80; A-81 and A-82.
Loss of L-arginine-enhanced L-leucine transport; when associated with A-79; A-80; A-81 and A-85.
Loss of L-arginine-enhanced L-leucine transport; when associated with A-79; A-80; A-82 and A-85.
Loss of L-arginine-enhanced L-leucine transport; when associated with A-79; A-81; A-82 and A-85.
Loss of L-arginine-enhanced L-leucine transport; when associated with A-80; A-81; A-82 and A-85.
Sodium-coupled neutral amino acid transporter 9
Insulin-like growth factor-binding protein 5
In del8; impaired visual function from an early age. Progressive degeneration of the retinal outer nuclear layer is detected from 2 months of age onwards, associated with increased apoptosis. Both rod and cone type photoreceptors show progressively reduced outer segment length. The photoreceptor outer segment proteins gnb3b and prph2 are mislocalized to the inner segment, and photoreceptor F-actin morphology is disrupted. Cone type photoreceptors also decline in number with age.
In rmc101; impaired visual function from an early age. Light-induced locomotor activity is significantly reduced. Morphology of the photoreceptor outer segment is impaired. Localization of rho (rhodopsin) and gnat2 to the photoreceptor outer segment and photoreceptor F-actin morphology is also disrupted.
SH3 and cysteine-rich domain-containing protein 3
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
Probable D-lactate dehydrogenase, mitochondrial
Vacuolar protein sorting-associated protein 26B
Lysophosphatidylcholine acyltransferase 2
Conserved oligomeric Golgi complex subunit 4
NF-kappa-B inhibitor-interacting Ras-like protein 2
S-adenosylmethionine sensor upstream of mTORC1
Tricarboxylate transport protein A, mitochondrial
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1B
Mild lens phenotype and severe coloboma. A small number of fish survive to adulthood.
Cleavage and polyadenylation specificity factor subunit 5
Leucine-rich repeat-containing protein 3
Coiled-coil domain-containing protein 40
In the eye lens, loss of targeting to mitochondria at the time of organelle rupture.
Neuronal PAS domain-containing protein 4A
Mediator of RNA polymerase II transcription subunit 6
Calcium/calmodulin-dependent protein kinase type II delta 2 chain
Pleckstrin homology domain-containing family H member 1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Myosin regulatory light chain 2, skeletal muscle isoform B
Vacuolar protein sorting-associated protein 18 homolog
Neuroblastoma suppressor of tumorigenicity 1
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A
Mitochondrial intermembrane space import and assembly protein 40
tRNA (uracil-5-)-methyltransferase homolog B
RNA-binding protein with serine-rich domain 1
Inhibits cell-proliferation and enhances apoptosis at low temperatures.
Transitional endoplasmic reticulum ATPase
Ras-associating and dilute domain-containing protein
Dehydrogenase/reductase SDR family member 6
Cilia- and flagella-associated protein 20
G-patch domain and KOW motifs-containing protein
Ubiquinol-cytochrome-c reductase complex assembly factor 3
Nuclear envelope integral membrane protein 2
Trimeric intracellular cation channel type B
N-acylneuraminate cytidylyltransferase B
Interferon-induced GTP-binding protein MxC
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B
Leukocyte receptor cluster member 8 homolog
LLGL scribble cell polarity complex component 2
Coiled-coil domain-containing protein 89
28S ribosomal protein S35, mitochondrial
G-protein coupled receptor family C group 6 member A
Threonylcarbamoyladenosine tRNA methylthiotransferase
RNA-binding protein, mRNA-processing factor 2a
Mediator of RNA polymerase II transcription subunit 21
Sodium-dependent phosphate transporter 1-A
Coiled-coil domain-containing protein 167
Non-canonical dileucine endocytic signal
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
cAMP-responsive element-binding protein-like 2
Short transmembrane mitochondrial protein 1
Eukaryotic translation initiation factor 4E-1A
Regulator of telomere elongation helicase 1
Nonsense-mediated mRNA decay factor SMG7
Asparagine synthetase domain-containing protein 1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Interleukin enhancer-binding factor 2 homolog
Transforming growth factor-beta receptor-associated protein 1 homolog
Acetyl-CoA acetyltransferase, mitochondrial
Mitochondrial ubiquitin ligase activator of nfkb 1-A
TYRO protein tyrosine kinase-binding protein
FGGY carbohydrate kinase domain-containing protein
Cholesterol 25-hydroxylase-like protein 1, member 2
CCR4-NOT transcription complex subunit 7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Phosphoinositide-3-kinase-interacting protein 1
Succinate dehydrogenase assembly factor 2, mitochondrial
Immediate early response gene 5-like protein
Uncharacterized protein C1orf112 homolog
Nuclear receptor subfamily 6 group A member 1-B
Protein phosphatase 1 regulatory subunit 3C-B
RNA binding protein fox-1 homolog 1-like
Vesicular, overexpressed in cancer, prosurvival protein 1
Probable ribosome biogenesis protein RLP24
Coiled-coil domain-containing protein 25
Loss of phosphorylation. Drastic reduction in SRC-binding and in activation of MAPK.
Zinc finger C2HC domain-containing protein 1A
Vacuolar protein sorting-associated protein 33B
CDGSH iron-sulfur domain-containing protein 2
Uncharacterized protein C18orf19 homolog B
Twisted gastrulation protein homolog 1-A
Uncharacterized protein C12orf29 homolog
Loss of transactivation activity. Suppression of irradiation-induced apoptosis. Defective G1-phase but not G2-phase checkpoint response. Development of malignant peripheral nerve sheath tumors. No effect on embryonic development.
Loss of transactivation activity. Temperature-sensitive suppression of irradiation-induced apoptosis. No effect on embryonic development.
NPC intracellular cholesterol transporter 2
Cerebral cavernous malformations protein 2 homolog
Loss of function in heart development. Loss of HEG-binding.
Serine palmitoyltransferase small subunit A
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B
Probable fructose-2,6-bisphosphatase TIGAR A
Receptor-type tyrosine-protein phosphatase alpha
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Leucine-rich repeat-containing protein 57
Schiff-base intermediate with substrate; via topaquinone
non-specific serine/threonine protein kinase
POU domain, class 3, transcription factor 3-B
Eukaryotic translation initiation factor 3 subunit A
Histone-lysine N-methyltransferase SETD1B-A
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Oligosaccharyltransferase complex subunit ostc
Aldo-keto reductase family 1 member A1-B
Growth hormone-regulated TBC protein 1-A
Doublesex- and mab-3-related transcription factor 3a
Inhibits the translocation of Dmrt3 into the nucleus.
Cilia- and flagella-associated protein 157
Mediator of RNA polymerase II transcription subunit 24
Sister chromatid cohesion protein PDS5 homolog A
Cytosolic Fe-S cluster assembly factor narfl
Kelch repeat and BTB domain-containing protein 8
In tg414b; Lethality between 6 and 14 days post-fertilization. Early ear development appears normal. The developing otic vesicle begins to collapse at 72 hours post-fertilization, probably due loss of endolymphatic fluid, and is significantly reduced in size by 5 days post-fertilization. Hair cells appear normal and there is no evidence of reduced cell numbers or apoptosis.
Moderately impairs transporter activity.
Gamma-aminobutyric acid receptor subunit alpha-2
Tumor necrosis factor, alpha-induced protein 8-like protein 2 B
Solute carrier family 52, riboflavin transporter, member 3-A
Mediator of RNA polymerase II transcription subunit 11
Haloacid dehalogenase-like hydrolase domain-containing protein 2
RanBP-type and C3HC4-type zinc finger-containing protein 1
Mannose-1-phosphate guanyltransferase alpha-A
Abrogates initiation of translation of isoform 2.
Eukaryotic translation initiation factor 3 subunit M
Cleavage and polyadenylation specificity factor subunit 6
Endosomal/lysosomal proton channel TMEM175
p21-activated protein kinase-interacting protein 1-like
Electron transfer flavoprotein beta subunit lysine methyltransferase
ADP-ribosylation factor-like protein 8B-A
Ras-related and estrogen-regulated growth inhibitor-like protein
Mannose-1-phosphate guanyltransferase alpha-B
17-beta-hydroxysteroid dehydrogenase type 3
Isoamyl acetate-hydrolyzing esterase 1 homolog
Transformation/transcription domain-associated protein
SLIT-ROBO Rho GTPase-activating protein 2
Schiff-base intermediate with dihydroxyacetone-P
Glycosyltransferase 8 domain-containing protein 1
Heparan-sulfate 6-O-sulfotransferase 1-A
Endoplasmic reticulum-Golgi intermediate compartment protein 2
Nuclear factor interleukin-3-regulated protein
Significantly reduces catalytic activity.
Calcium-binding and coiled-coil domain-containing protein 1
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
In dali; retained in the endoplasmic reticulum. Incomplete N-glycosylation. Defective migration and cell-cell interaction between melanophores and xanthophores, leading to abnormal pigment stripe patterning.
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
ATP-binding cassette sub-family D member 1
Influenza virus NS1A-binding protein homolog B
Lower affinity for AMOTL2-binding compared with wild-type.
Proto-oncogene tyrosine-protein kinase Src
Histone-lysine N-methyltransferase SUV39H1-A
Short-chain dehydrogenase/reductase family 42E member 1
Endoplasmic reticulum-Golgi intermediate compartment protein 1
PTB domain-containing engulfment adapter protein 1
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Coiled-coil domain-containing protein 149-B
Glycerol-3-phosphate acyltransferase 3-like
Spindle and kinetochore-associated protein 1
Glycoprotein endo-alpha-1,2-mannosidase-like protein
Abolishes tRNA ligase activity. No effect on ability to regulate sprouting angiogenesis.
In sars-s277; pronounced dilatation of the aortic arch vasculature at 72 hpf and subsequent aberrant branching of the hindbrain capillary network.
Solute carrier family 2, facilitated glucose transporter member 12
Ras-specific guanine nucleotide-releasing factor 2
WD repeat, SAM and U-box domain-containing protein 1
Acts as dominant negative. Inhibits activation of MAP kinase p38 and disrupts cleavage.
Dual specificity mitogen-activated protein kinase kinase 6
Serine/threonine-protein phosphatase 4 regulatory subunit 3
Microtubule-associated tumor suppressor 1 homolog A
Coenzyme Q-binding protein COQ10 homolog, mitochondrial
Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A
Coiled-coil domain-containing protein 85B
Meiosis expressed gene 1 protein homolog
Survival of motor neuron-related-splicing factor 30
Iron-sulfur clusters transporter ABCB7, mitochondrial
ATP synthase mitochondrial F1 complex assembly factor 1
Thyroid transcription factor 1-associated protein 26 homolog
Receptor-type tyrosine-protein phosphatase
Hairy and enhancer of split-related protein helt
Coiled-coil domain-containing protein 102A
Sodium-coupled neutral amino acid symporter 2
Isochorismatase domain-containing protein 1
Thioredoxin reductase-like selenoprotein T1b
Bombesin receptor-activated protein C6orf89 homolog
Diencephalon/mesencephalon homeobox protein 1-B
Transmembrane and ubiquitin-like domain-containing protein 1
Spindle assembly abnormal protein 6 homolog
Ventricular zone-expressed PH domain-containing protein
5-aminolevulinate synthase, erythroid-specific, mitochondrial
F-box and WD repeat domain-containing 11-A
Glycylpeptide N-tetradecanoyltransferase 2
Fibronectin type III domain-containing protein 5
Eukaryotic translation initiation factor 3 subunit I
Xenotropic and polytropic retrovirus receptor 1 homolog
Sorting and assembly machinery component 50 homolog B
Dual serine/threonine and tyrosine protein kinase
reversibly protonated residue during proton transport
N-acetylglucosamine-6-phosphate deacetylase
Mediator of RNA polymerase II transcription subunit 20
Interleukin-1 receptor accessory protein-like 1-A
Actin filament-associated protein 1-like 1
Probable cationic amino acid transporter
Disintegrin and metalloproteinase domain-containing protein 10
Twisted gastrulation protein homolog 1-B
Inosine-5'-monophosphate dehydrogenase 1b
In pac(fr7); causes abnormal embryonic brain and tail morphogenesis.
In pac(tm101B); causes abnormal embryonic brain and tail morphogenesis.
Phosphatidylinositol-3-phosphatase SAC1-B
RNA pseudouridylate synthase domain-containing protein 1
tRNA wybutosine-synthesizing protein 3 homolog
Coiled-coil domain-containing protein 22
Protein transport protein Sec61 subunit alpha-like 2
In bar(S847); increased oxidative stress, DNA damage and cell death specifically in blood vessels and the heart.
In reh(S587); cranial vascular hemmorhages in multiple areas of the head, leading to death by 72 hpf.
UbiA prenyltransferase domain-containing protein 1
Protein kinase C and casein kinase substrate in neurons protein 1
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Glycerol-3-phosphate dehydrogenase 1-like protein
Intraflagellar transport protein 172 homolog
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Phenylalanine--tRNA ligase alpha subunit
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Ubiquitin carboxyl-terminal hydrolase 20
Lutropin-choriogonadotropic hormone receptor
Acyl-CoA-binding domain-containing protein 6
Dorsal-ventral patterning tolloid-like protein 1
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Insulin-like growth factor-binding protein 3
Probable E3 ubiquitin-protein ligase RNF144A-B
Ribosome biogenesis protein C1orf109 homolog
Ubiquitin-conjugating enzyme E2 variant 2
Calcium-binding mitochondrial carrier protein SCaMC-1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Mediator of RNA polymerase II transcription subunit 29
All-trans-retinyl ester 13-cis isomerohydrolase
Tumor necrosis factor receptor superfamily member 6
4-trimethylaminobutyraldehyde dehydrogenase B
60S ribosome subunit biogenesis protein NIP7 homolog
Staphylococcal nuclease domain-containing protein 1
Cytidine and dCMP deaminase domain-containing protein 1
Substitution with a bulky side chain that mimicks covalent modification by an electrophile; prevents ubiquitination and degradation of nfe2l2/nrf2, leading to constitutive activation of nfe2l2/nrf2.
Substitution with a small side chain that prevents covalent modification by an electrophile; promotes constitutive ubiquitination of nfe2l2/nrf2 and subsequent repression of phase 2 detoxifying enzymes.
NAD-dependent protein deacetylase sirtuin-2
Major facilitator superfamily domain-containing protein 4B
In rs7; mutant embryos have a small head and a curled tail by day 2 and die by the end of day 3. Mutation causes increased sensitivity to IR-induced apoptosis. Mutants do not show changes in alternative splicing.
Protein-L-isoaspartate O-methyltransferase
Probable 39S ribosomal protein L24, mitochondrial
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Coiled-coil domain-containing protein 103
Thioredoxin domain-containing protein 12
Activating molecule in BECN1-regulated autophagy protein 1A
CCR4-NOT transcription complex subunit 1
Ubiquitin carboxyl-terminal hydrolase 22
Ganglioside-induced differentiation-associated protein 2
26S proteasome non-ATPase regulatory subunit 11A
ADP-ribosylation factor-like protein 13B
Abolishes ability to rescue a arl13b mutant when transfected, without affecting localization to cilium.
Store-operated calcium entry-associated regulatory factor
von Willebrand factor C domain-containing protein 2-like
Dual specificity protein phosphatase 22-A
Transcription initiation factor TFIID subunit 8
Zinc finger CCCH domain-containing protein 15
Fibronectin type III and SPRY domain-containing protein 1
Cytosolic endo-beta-N-acetylglucosaminidase
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A
Abolishes thalidomide-binding; when associated with A-374.
Abolishes thalidomide-binding; when associated with A-376.
Mitochondrial import inner membrane translocase subunit Tim10 B
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Activity-dependent neuroprotective protein a
Transforming growth factor-beta-induced protein ig-h3
N6-adenosine-methyltransferase subunit METTL3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
Unhealthy ribosome biogenesis protein 2 homolog
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
In lau; allele tb233c; semicircular canal defects.
In lau; allele tk256a; semicircular canal defects.
In stl215; mutants developp swollen ears, fail to express mbp and do not myelinate peripheral axons.
Eukaryotic translation initiation factor 3 subunit C
26S proteasome non-ATPase regulatory subunit 11B
POU domain, class 3, transcription factor 3-A
Neuronal PAS domain-containing protein 4-like
Trafficking protein particle complex subunit 11
Serine/threonine-protein phosphatase 4 regulatory subunit 2-B
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
Mitotic spindle assembly checkpoint protein MAD2B
Causes Kupffer's vesicle formation defects, melanosome transport delays and visual impairment.
Cilia- and flagella-associated protein 418
Solute carrier organic anion transporter family member
Kringle-containing protein marking the eye and the nose
MKI67 FHA domain-interacting nucleolar phosphoprotein
Eukaryotic translation initiation factor 4E type 3
Hydroxysteroid dehydrogenase-like protein 2
Sodium-dependent phosphate transporter 1-B
B-cell CLL/lymphoma 7 protein family member A
Dehydrogenase/reductase SDR family member 7C-B
Olfactory receptor class A-like protein 4
AT-rich interactive domain-containing protein 3A
In hu3587; Viable, with most animal surviving to 3 months of age.
In sa0011; Lethality occurs from 4 days post-fertilization (dpf) onwards with no survival beyond 7 dpf. Severe developmental abnormalities are apparent from 48 hours post-fertilization (hpf) onwards including curved body, small head and a progressive reduction in eye size. At later stages there are signs of pericardial edema and the swim bladder is absent. Neurodegeneration is present in the retina, optic tectum and cerebellum, associated with increased apoptosis and reduced cell proliferation. Locomotor behavior is abnormal with increased movement, aberrant swimming patterns and a twitching phenotype. Significantly reduced peptidase activity and accumulation of the tpp1 substrate, subunit c of mitochondrial ATP synthase.
Cilia- and flagella-associated protein 206
Low-density lipoprotein receptor-related protein
Cysteine-rich and transmembrane domain-containing protein 1
Diencephalon/mesencephalon homeobox protein 1-A
Unable to rescue a phf8 morpholino mutant.
Junction-mediating and -regulatory protein
Signal recognition particle 54 kDa protein
Mediator of RNA polymerase II transcription subunit 25
Elongation of very long chain fatty acids protein 6
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Cholesterol 25-hydroxylase-like protein 2
Abolishes endoplasmic reticulum localization.
Does not abolish endoplasmic reticulum localization.
Swi5-dependent recombination DNA repair protein 1 homolog
Peptide-methionine (R)-S-oxide reductase
Glycosyltransferase-like domain-containing protein 1
Phytanoyl-CoA hydroxylase-interacting protein-like
Interleukin enhancer-binding factor 3 homolog
Nuclear receptor subfamily 2 group F member 1-A
DBH-like monooxygenase protein 1 homolog
In frs-ij001; induces embryonic hypochronic anemia.
In frs-tg180; induces embryonic hypochronic anemia.
In frs-tg221; induces embryonic hypochronic anemia.
In frs-tm130; induces embryonic hypochronic anemia.
In frs-tq223; induces embryonic hypochronic anemia.
Inhibits RNA-binding and the relieve of miRNA repression activity.
Cysteine and histidine-rich domain-containing protein 1
SH3 domain-binding glutamic acid-rich-like protein 2
Complex I assembly factor TIMMDC1, mitochondrial
'Ionic lock' involved in activated form stabilization
Potassium voltage-gated channel subfamily D member 2
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
Bactericidal permeability-increasing protein
Translation machinery-associated protein 7
Mothers against decapentaplegic homolog 1
Succinate dehydrogenase assembly factor 3, mitochondrial
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Platelet-derived growth factor subunit B
Epithelial splicing regulatory protein 2
RecQ-mediated genome instability protein 1
Abolishes maternal ctnnb1 signaling resulting in a loss of chd expression.
Probable sodium-coupled neutral amino acid transporter 6
Coiled-coil domain-containing protein 125
Interferon regulatory factor 2-binding protein 2-A
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Eukaryotic translation initiation factor 3 subunit L
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Arginine-hydroxylase NDUFAF5, mitochondrial
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A
H/ACA ribonucleoprotein complex subunit 3
Trafficking protein particle complex subunit 13
39S ribosomal protein L14, mitochondrial
Mediator of RNA polymerase II transcription subunit 28
Interferon regulatory factor 2-binding protein 1
Tricarboxylate transport protein B, mitochondrial
Bcl-2-related ovarian killer protein homolog B
Ankyrin repeat domain-containing protein 46
Tumor necrosis factor alpha-induced protein 8-like protein 3
Odontogenic ameloblast-associated protein
Mitochondrial inner membrane protease ATP23 homolog
LHFPL tetraspan subfamily member 6 protein
Sigma non-opioid intracellular receptor 1
Synapse differentiation-inducing gene protein 1-like
SKI8 subunit of superkiller complex protein
Plasma membrane ascorbate-dependent reductase CYBRD1
Transcription initiation factor TFIID subunit 2
Pleckstrin homology domain-containing family A member 7
Mitochondrial import inner membrane translocase subunit TIM14
Zinc-regulated GTPase metalloprotein activator 1
Nuclear distribution protein nudE-like 1-A
Ribitol-5-phosphate xylosyltransferase 1
Actin, cytoplasmic 2, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 2, N-terminally processed
N-acetylmethionine; in Actin, cytoplasmic 2; alternate
Vacuolar ATPase assembly integral membrane protein vma21
Hydroxyacylglutathione hydrolase, mitochondrial
Mapk-regulated corepressor-interacting protein 1
Guanine nucleotide-binding protein subunit beta-2-like 1
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Active breakpoint cluster region-related protein
Protein prenyltransferase alpha subunit repeat-containing protein 1
Cilia- and flagella-associated protein 161
Protein N-lysine methyltransferase METTL21A
Transcription factor IIIB 50 kDa subunit
In Man o' war (mow) mutant; characterized by severe craniofacial defects. Fishes show defective organization and morphogenesis of chondrocytes, perichondrium and bone.
Mothers against decapentaplegic homolog 5
Serine/threonine-protein phosphatase 4 catalytic subunit A
Vacuolar protein sorting-associated protein 51 homolog
Calcium release-activated calcium channel protein 1
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Intraflagellar transport protein 57 homolog
Interchain (with C-? in TGFB1); in linked form
Transforming growth factor beta activator LRRC33
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Probable vesicular acetylcholine transporter-B
Katanin p60 ATPase-containing subunit A1
In mil; allele m93; lack of S1P-mediated signaling.
In mil; allele te273; lack of S1P-mediated signaling.
Glycoprotein integral membrane protein 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Mediator of RNA polymerase II transcription subunit 15
Ubiquitin carboxyl-terminal hydrolase 30
ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding and stabilization
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Ras and EF-hand domain-containing protein
Heparan-sulfate 6-O-sulfotransferase 1-B
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Dehydrodolichyl diphosphate synthase complex subunit nus1
Tumor necrosis factor, alpha-induced protein 8-like protein 2 A
BTB/POZ domain-containing protein kctd15-like
Interchain (between alpha and beta chains)
tRNA wybutosine-synthesizing protein 2 homolog
Major facilitator superfamily domain-containing protein 1
In y17; abolishes kinase activity and causes specific defects in artery development.
Vascular endothelial growth factor receptor kdr-like
Glutamine amidotransferase-like class 1 domain-containing protein 1
Post-GPI attachment to proteins factor 3
Ankyrin repeat and BTB/POZ domain-containing protein 3-A
Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Coiled-coil domain-containing protein 85C-A
Phytanoyl-CoA dioxygenase domain-containing protein 1
Hairy/enhancer-of-split related with YRPW motif-like protein
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
2-oxoglutarate and iron-dependent oxygenase JMJD4
Coiled-coil domain-containing protein 124
Glyceraldehyde-3-phosphate dehydrogenase
Interleukin-1 receptor-associated kinase 1-binding protein 1 homolog
Cytochrome b5 domain-containing protein 1
Schiff-base intermediate with DNA; for 5'- deoxyribose-5-phosphate lyase activity
Ubiquitin-conjugating enzyme E2 variant 3
Lipid droplet-regulating VLDL assembly factor AUP1
T-cell acute lymphocytic leukemia protein 1 homolog
Ciliogenesis-associated TTC17-interacting protein
Pyridoxal-dependent decarboxylase domain-containing protein 1
tRNA N6-adenosine threonylcarbamoyltransferase
Cyclic AMP-responsive element-binding protein 3-like protein 2
Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Leucine-rich repeat-containing protein 40
Probable helicase with zinc finger domain
POU domain, class 3, transcription factor 1
Cytosolic carboxypeptidase-like protein 5
39S ribosomal protein L54, mitochondrial
WD repeat and SOCS box-containing protein 1
Coxsackievirus and adenovirus receptor homolog