Gamma-tubulin complex component 2 homolog
DNA polymerase epsilon catalytic subunit 1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Mini-chromosome maintenance complex-binding protein
Transcription initiation factor IIA subunit 2-2
Gustatory and pheromone receptor 39a, isoform A
Gustatory and pheromone receptor 39a, isoform B
Gustatory and pheromone receptor 39a, isoform C
Gustatory and pheromone receptor 39a, isoform D
Thyroid adenoma-associated protein homolog
Bromodomain-containing protein DDB_G0280777
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
N6-adenosine-methyltransferase non-catalytic subunit
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cleavage and polyadenylation specificity factor subunit 6
In allele WO49; impedes segmental patterning of the embryo and the heat shock response.
In allele lgs-17E; segment polarity phenotype.
tRNA (cytosine(34)-C(5))-methyltransferase
In allele 11; may cause loss of zinc binding.
In allele 13; may alter structure of LIM domain.
In allele 17; may alter structure of LIM domain.
Results in age-dependent locomotor defects and neurodegeneration.
Ubiquitin carboxyl-terminal hydrolase Usp2
Increased interaction with Akt1 and some negative regulation of Atk1. Increased interaction with slbo but no effect on negative regulation of slbo-dependent border cell migration. No effect on interaction and negative regulation of stg-dependent cell divisions in the wing.
No effect on mitosis. Embryos display an early pause in the cell cycle similar to wild-type.
Partial loss of border cell migration when expressed in border cells.
Reduced interaction and inhibition of Akt1 resulting in increased Akt1-mediated growth and loss of carbohydrate clearance from the hemolymph. No effect on interaction with slbo and stg, and no effect on the negative regulation of slbo-dependent border cell migration and stg-dependent cell divisions in the wing.
Reduced interaction with Akt1 and reduced inhibition of Akt1-mediated growth. Reduced interaction with slbo and fails to block border cell migration. No effect on cell division in the posterior compartment of the wing.
Elongation of very long chain fatty acids protein 6
39S ribosomal protein L55, mitochondrial
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1
Eukaryotic translation initiation factor 3 subunit D-1
Homolog of P-1673 variant in human. Does not rescue cac-F and cac-J lethal phenotypes. Highly increases amplitude on the synaptic transmission. Induces severe neurodegeneration in both photoreceptor cell bodies and terminals.
Homolog of Q-1664 variant in human. Partially rescues the cac-F and cac-J lethal phenotypes. Does not rescue the loss of synaptic transmission cac-F and cac-J variants. No effect on photoreceptor morphology.
In cac-F; lethal at the larval stage 3; loss of synaptic transmission.
In cac-J; lethal at an embryonic stage; loss of synaptic transmission.
In cac-S; exhibits defects in the patterning of courtship lovesong and a subtle abnormality in visual physiology.
Voltage-dependent calcium channel type A subunit alpha-1
CD2 antigen cytoplasmic tail-binding protein 2 homolog
F-box-like/WD repeat-containing protein ebi
In ebi4; induces defects in R7 cell development in the eye.
In ebiCC1; induces ectopic S phases within the peripheral and central nervous system.
In ebiCC3; induces ectopic S phases within the peripheral and central nervous system.
Leucine-rich repeat-containing protein 15
Probable arginine--tRNA ligase, cytoplasmic
Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Molybdopterin synthase sulfur carrier subunit
Helical; Signal-anchor for type II membrane protein
Putative polypeptide N-acetylgalactosaminyltransferase 9
Results in secretory granule defects including an angular and shard-like morphology.
Probable trafficking protein particle complex subunit 13 homolog
2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-588.
2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-591.
2-fold reduction in zinc transport activity in yeast assay; when in association with A-588 and A-591.
2-fold reduction zinc transport activity in yeast assay.
4-fold reduction in zinc transport activity in yeast assay.
Severely reduced zinc transport activity in yeast assay.
In mus304-3; induces abnormal bristle morphology, decreased meiotic recombination and arrested embryonic development.
In mus304-4; induces abnormal bristle morphology, decreased meiotic recombination and arrested embryonic development.
In mus304-6; induces abnormal bristle morphology, decreased meiotic recombination and arrested embryonic development.
In strain: MW11, MW27, MW38, MW56, MW9, NC390 and NC740.
In strain: MW11, MW27, MW6, MW9 and NC774.
In strain: MW56, NC335, NC336, NC362, NC740 and NC774.
In strain: NC304, NC335, NC350, NC397, NC732 and MW9.
Abolishes enzyme activity but retains PGN-binding.
Abolishes Monooxygenase activity and impairs axon guidance functions.
Results in increased localization to mitochondria.
Results in neuronal terminal arborization defects and loss of neuroblasts.
Suppresses accumulation at the synapse, reduced fly viability and defective neuromuscular junction; when associated with K-320.
When overexpressed in the whole body or mesoderm, impairs development and reduces longevity. When overexpressed in neurons, impairs progressively neuronal functionality and morphology.
When overexpressed in the whole body, leads to motor deficits, progressive neuromuscular junction (NMJ) denervation and pre-synaptic build-up of mutant GlyRS ultimately causing lethality. Similar effects are shown when overexpressed in the mesoderm or neurons. Accumulates at the synapse. When overexpressed in neurons, impairs progressively neuronal functionality and morphology. Toxicity might be mediated by modulation of the plexin-semaphorin signaling. Suppresses accumulation at the synapse, reduced fly viability and defective neuromuscular junction; when associated with 97-A--F-163 DEL.
Abolishes interaction with lack; when associated with A-453.
Abolishes interaction with lack; when associated with A-455.
N-alpha-acetyltransferase 35, NatC auxiliary subunit homolog
G_PROTEIN_RECEP_F3_4 domain-containing protein
Beta-alanyl-bioamine nonribosomal peptide synthetase ebony
Impairs attachment of prosthetic group pantetheine 4'-phosphate and thus, the transfer of beta-alanine to the carrier domain. No effect on beta-alanine adenylation. Causes dark body pigmentation.
Putative ferric-chelate reductase 1 homolog
PHD finger-like domain-containing protein 5A
In strain: Canton-S, SENGWA2, SENGWA22, SENGWA29, SENGWA32 and SENGWA51.
In strain: SENGWA2, SENGWA22, SENGWA29, SENGWA30, SENGWA32, SENGWA37, SENGWA51, WSII16, WSII19 and WSII49.
In strain: SENGWA2, SENGWA22, SENGWA29, SENGWA32, SENGWA37, SENGWA51, WSII19 and WSII49.
In strain: SENGWA2, SENGWA29, SENGWA32, SENGWA51, WSII19 and WSII49.
In strain: SENGWA22, SENGWA29, SENGWA37 and SENGWA51.
In strain: SENGWA22, SENGWA30 and WSII16.
In strain: SENGWA29, SENGWA30, SENGWA37 and SENGWA51.
Lipid storage droplets surface-binding protein 2
Intermembrane lipid transfer protein Vps13
Small nuclear ribonucleoprotein-associated protein B
Unable to localize to the pole plasm; when associated with G-130; L-145; L-174; L-181; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-174; L-181 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-174; L-181 and L-189.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-174; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-181; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-174; L-181; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; L-145; L-174; L-181; L-189 and G-196.
Activity-regulated cytoskeleton associated protein 1
In strain: LA116, LA25, LA4, MA24, MA45, MA50, MW37, MW6 and MW9.
In strain: LA116, MA45, MA50, MW37, MW6 and MW9.
In strain: LA116, MA45, MA50, MW37, MW6, MW9, NC52a and NC73a.
In strain: MA45, MA50, MW37, MW6 and MW9.
In strain: NC21a, NC52a, NC62a, NC73a and NC79b.
Probable G-protein coupled receptor Mth-like 7
Mannose-P-dolichol utilization defect 1 protein homolog
Probable DNA-directed RNA polymerase III subunit RPC6
Reduced survival rate after 50 days of age. Decreased aminoacylation, increased misacylation of non-cognate Tyr, increased amino acid misincorporation, ommatidia defects, neurodegeneration, impaired locomotive performance, reduced lifespan, smaller organ size due to apoptosis and increased ER stress; when associated with 'G-456' in alpha subunit.
Guanine nucleotide exchange factor MSS4 homolog
receptor protein serine/threonine kinase
Raf homolog serine/threonine-protein kinase Raf
26S proteasome non-ATPase regulatory subunit 1
Loss of binding with Gorab and thus abolishes subcellular localization of Gorab at the centriole. No effect on homodimerization or localization of Gorab to the Golgi. Partially rescues coordination defects and centriole loss in the null mutant.
No effect on binding with Gorab or homodimerization.
No effect on binding with Gorab or homodimerization. Rescues coordination defects and centriole loss in both interphase and mitotic cells of the null mutant.
Spindle assembly abnormal protein 6 homolog
Sodium- and chloride-dependent GABA transporter ine
Kinase-dead. No effect on interaction with drpr.
Protein N-terminal glutamine amidohydrolase
Eukaryotic translation initiation factor 4E-binding protein
In d4E-BP(LL) mutant; increased interaction with eIF4E1; expression of this mutant in wing-imaginal disks causes a reduction of wing size, caused by a decrease in cell size and number.
Phosphomimetic mutant; does not affect interaction with free eIF4E1.
Strongly decreased interaction with eIF4E1.
BPTI/Kunitz inhibitor domain-containing protein
Ragulator complex protein LAMTOR2 homolog
Echinoderm microtubule-associated protein-like CG42247
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 2
In strain: Berkeley, k1, k2, k3, k5, k8, k9 and k11.
In strain: Berkeley, k1, k2, k3, k5, k8, k9, k11, pe1, pe4, pe45, pe5, wi4, wi7, wi10, wi13, wi18 and wi19.
In strain: Berkeley, k1, k8, Oregon-R, pe7 and pe10.
In strain: Berkeley, k3, k8, k9, wi10 and wi19.
Eukaryotic translation initiation factor 3 subunit L
AB hydrolase-1 domain-containing protein
Cytochrome c oxidase assembly factor 7 homolog
No change in baseline secretion but eliminates increased secretion normally caused by coexpression with Hip14 and reduces intracellular levels of Sog.
No effect on secretion when coexpressed with Hip14.
In shf2; induces defects in the hh pathway.
In shf919; induces defects in the hh pathway.
Ubiquitin fusion degradation protein 1 homolog
Helical; Anchor for type IV membrane protein
DNA-directed RNA polymerase III subunit RPC2
Inhibitor of nuclear factor kappa-B kinase subunit beta
Conserved oligomeric Golgi complex subunit 6
Putative ATP-dependent RNA helicase CG14443
Abolishes binding to Z600; when associated with A-235 and A-239.
Abolishes binding to Z600; when associated with A-235 and A-242.
Abolishes binding to Z600; when associated with A-239 and A-242.
In strain: LAMTO 13, LAMTO 37 and LAMTO 134.
In strain: LAMTO 3, LAMTO 4, LAMTO 12, LAMTO 18, LAMTO 19, LAMTO 21, LAMTO 31, LAMTO 35, LAMTO 101 and LAMTO 111.
Serine/threonine-protein phosphatase 4 regulatory subunit 3
Chitin-binding type-2 domain-containing protein
Open rectifier potassium channel protein 1
Abolishes formation of methionine-sulfoxide and subsequent depolymerization.
Vacuolar protein sorting-associated protein 54
Mediator of RNA polymerase II transcription subunit 27
U3 small nucleolar RNA-associated protein 18 homolog
In strain: XCPA4, XCPA7, XCPA25, XCPA51, XCPA77, XCPA93, XCPA102, XCPA105, XCPA122 and XCPA125.
Ca(2+)/calmodulin-responsive adenylate cyclase
Mediator of RNA polymerase II transcription subunit 14
Nucleosome-remodeling factor subunit NURF301
Transcription initiation factor TFIID subunit 10
Autolysis site shifted to nearby, less-active site(s).
Autolysis site shifted to nearby, less-active sites.
Double-stranded RNA-specific editase Adar
Mitochondrial E3 ubiquitin protein ligase 1
Kunitz/Bovine pancreatic trypsin inhibitor domain protein
Decreased transposon silencing but no effect on nuclear localization or interaction with piwi.
In allele 339; strong reduction in head size.
Transcription initiation factor TFIID subunit 6
Abrogates microtubule severing and ATPase activity.
Abrogates microtubule severing and ATPase activity. Induces accumulation of hyperstable microtubules at the neuromuscular junction presynpatic terminal and reduces synaptic area. Reduces adult lifespan and impairs climbing activity.
Abrogates microtubule severing and impairs ATPase activity.
Abrogates microtubule severing and strongly impairs ATPase activity.
Impairs interaction with microtubules and promotes hexamerization.
Impairs microtubule severing and ATPase activity.
Strongly impairs microtubule severing and ATPase activity but does not affect interaction with microtubules; when associated with A-469 and A-473.
Strongly impairs microtubule severing and ATPase activity but does not affect interaction with microtubules; when associated with A-469 and A-474.
Strongly impairs microtubule severing and ATPase activity but does not affect interaction with microtubules; when associated with A-473 and A-474.
Strongly impairs microtubule severing and ATPase activity.
Strongly impairs microtubule severing and weakly impairs ATPase activity.
Strongly impairs microtubule severing and weakly impairs ATPase activity; when associated with A-465 and A-471.
Strongly impairs microtubule severing and weakly impairs ATPase activity; when associated with A-465 and A-472.
Strongly impairs microtubule severing and weakly impairs ATPase activity; when associated with A-471 and A-472.
Weakly impairs microtubule severing and ATPase activity.
Weakly impairs microtubule severing and strongly impairs ATPase activity.
Eukaryotic translation initiation factor 3 subunit K
40S ribosomal protein S12, mitochondrial
Putative fatty acyl-CoA reductase CG5065
Pre-rRNA-processing protein TSR1 homolog
Abolishes phosphorylation by TORC1 signaling. Results in loss of nucleolar localization.
Reduces expression levels; does not affect phosphorylation.
Probable small nuclear ribonucleoprotein Sm D2
Tetratricopeptide repeat protein 19 homolog, mitochondrial
GMC_OxRdtase_N domain-containing protein
Uncharacterized zinc finger protein CG2678
Mannose-1-phosphate guanyltransferase beta
Ubiquitin carboxyl-terminal hydrolase 47
Queuine tRNA-ribosyltransferase accessory subunit 2
Shows high levels of reactive oxygen species (ROS) and accumulation of lipid droplets in pigment and epithelial glia. Lipid droplet accumulation occurs early, prior to the onset of neurodegeneration.
Homologous recombination repair is reduced by 70% resulting in mutants displaying extreme sensitivity to various DNA damaging agents, except for camptothecin.
Rescues bristle and female fertility defects in mutants.
Unable to rescue bristle and female fertility defects in mutants.
UbiA prenyltransferase domain-containing protein 1 homolog
DNA-directed RNA polymerase II subunit RPB2
Zinc finger CCCH-type with G patch domain-containing protein
ATP synthase subunit alpha, mitochondrial
Probable mitochondrial import inner membrane translocase subunit Tim17 3
Serine/threonine-protein phosphatase 2B catalytic subunit 3
Fragile X messenger ribonucleoprotein 1 homolog
Significant loss of Scm-binding activity.
Acetylcholine receptor subunit alpha-like 2
Structure-specific endonuclease subunit SLX1 homolog
Mediator of RNA polymerase II transcription subunit 9
Putative ATP-dependent RNA helicase BoYb
Cleavage and polyadenylation specificity factor subunit 1
Decreased function in sphingolipid catabolic process.
Helical; Signal-anchor for type III membrane protein
Loss of function in sphingolipid catabolic process.
No effect on function in sphingolipid catabolic process.
In strain: 399A, 774A, 852A, 859A, Congo13, Congo194 and Congo346.
In strain: 5, 7, 399A, 591A, 799A, 852A, 859A, Amherst, Congo13, Congo194, Congo216 and Congo346.
Inhibits interaction with loco. Does not inhibit apical cell membrane localization in neuroblasts.
Multiple inositol polyphosphate phosphatase 1
cAMP-dependent protein kinase type I regulatory subunit
Mitochondrial import receptor subunit TOM40 homolog 1
Gamma-tubulin complex component 4 homolog
Putative fatty acyl-CoA reductase CG8306
Glycine-rich cell wall structural protein 1
3-fold increase in sensitivity to cocaine inhibition of transport.
N-linked (GlcNAc...) asparagine; atypical
Loss of activity. Decrease in focal adhesion kinase (FAK) phosphorylation and loss of cell spreading; when associated with L-253.
Loss of activity. Decrease in focal adhesion kinase (FAK) phosphorylation and loss of cell spreading; when associated with V-255.
In isoform 1, isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
In isoform 1, isoform 3, isoform 5, isoform 7 and isoform 9.
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog
Transcription termination factor 5, mitochondrial
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Probable 28S ribosomal protein S6, mitochondrial
Abolishes adenylyltransferase and phosphodiesterase activities.
Disrupts homodimerization, leading to increased adenylyltransferase activity and reduced phosphodiesterase activity.
Promotes adenylyltransferase activity. Overexpression is lethal in a Fic null background.
Ragulator complex protein LAMTOR3 homolog
Protein bunched, class 1/class 3/D/E isoforms
26S proteasome non-ATPase regulatory subunit 14
In strain: Raleigh Inbred 6, Raleigh Inbred 9, Raleigh Inbred 11 and Raleigh Inbred 33.
In strain: Raleigh Inbred 6, Raleigh Inbred 9, Raleigh Inbred 11, Raleigh Inbred 27 and Raleigh Inbred 33.
Disrupts the RING finger domain. During meiosis, DNA double-strand break formation is normal but their conversion into cross-overs fails.
Mediator of RNA polymerase II transcription subunit 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Armadillo repeat-containing protein 6 homolog
Trypsin delta/gamma-like protein CG30031
DNA repair and recombination protein RAD54-like
No ATPase or chromatin remodeling activity.
Partial ATPase and low chromatin remodeling activity.
Reduced ATPase activity and loss of chromatin remodeling and strand pairing activities.
ATP-binding cassette sub-family D member 1
Cold shock domain-containing protein CG9705
Eukaryotic translation initiation factor 3 subunit A
Protein kinase domain-containing protein
In D44; reduces polyubiquitination by Diap2, abolishes rel cleavage and blocks expression of DptA following bacterial infection. No effect on binding to Diap2 or Fadd, processing, dimerization, catalytic activity or stability.
In L23; blocks expression of DptA following bacterial infection.
Tumor necrosis factor alpha-induced protein 8-like protein
Translation machinery-associated protein 16 homolog
Fibrinogen C-terminal domain-containing protein
Abolishes binding to Diap2 but has no effect on Drice processing or activity.
No effect on binding to Diap2 but may affect stability of complex formed with Diap2.
Transcription initiation factor TFIID subunit 2
Mediator of RNA polymerase II transcription subunit 15
Ankyrin repeat and KH domain-containing protein mask
In strain: Oregon-R, ZBMEL84, ZBMEL95, ZBMEL131, ZBMEL157, ZBMEL186, ZBMEL191 and ZBMEL229.
Mostly localized to cytoplasm. Does not affect interaction with and protein level stabilization of ND-42.
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog
rRNA N6-adenosine-methyltransferase Mettl5
Intraflagellar transport protein 172 homolog
Guanylate kinase-associated protein mars
Displays defects in chp trafficking to the membrane and mislocalization of ninaE, Rh3 and Rh4 in photoreceptors. Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with or without A-63 or L-310. Mild photoreceptor cell and microvillar disorganization; when associated with A-306. No phenotype; when associated with L-62.
Mild photoreceptor cell and microvillar disorganization; when associated with V-276.
No phenotype; when associated with V-276.
Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with V-276.
Loss of enzyme activity. Increase in apoptotic cells in the eye and wing. Increase in bristle number in the interommatidial lattice and decrease in pigment cell number. Disrupts vesicular localization of dock in spermatocytes. Fails to rescue the nurse cell plasma membrane defects and male sterility observed in null mutants. Fails to rescue the small eye phenotype induced by hid but able to rescue the small eye phenotype induced by rpr.
Loss of enzyme activity. Many embryos die before hatching. Fails to promote yki-dependent tissue growth in the eye and wing. Overexpression in wing imaginal disks frequently results in wings with blisters and ectopic veins. Eyes are disorganized and ommatidia are almost completely absent, eye bristles are not present in posterior two-thirds of the eye and bristle clusters occur at the anterior end. Increased Egfr endocytosis in embryos. No effect on Dpp expression in the leading edge cells.
Does not lead to transitional endoplasmic reticulum sites disassembly. Partially rescue transitional endoplasmic reticulum site disassembly induced by amino-acid starvation.
Does not lead to transitional endoplasmic reticulum sites disassembly; when associated with A-190.
Does not lead to transitional endoplasmic reticulum sites disassembly; when associated with F-192.
Steroidogenic acute regulatory protein-like
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Abolishes interaction with Nedd4, ubiquitination and internalization; when associated with A-221.
Abolishes interaction with Nedd4, ubiquitination and internalization; when associated with A-230.
Polypeptide N-acetylgalactosaminyltransferase 5
Helical; Voltage-sensor; Name=Segment S4
Potassium voltage-gated channel protein Shaker
cGMP-specific 3',5'-cyclic phosphodiesterase
Phosphatidate cytidylyltransferase, mitochondrial
Eukaryotic translation initiation factor 3 subunit D-2
Proton donor; shared with dimeric partner
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Protein still life, isoforms C/SIF type 2
Ribosome biogenesis protein WDR12 homolog
Loss of InsP6 phosphatase activity. Fails to rescue the filopodia formation phenotype of null mutants.
Molybdenum cofactor synthesis protein cinnamon
Loss of autoinhibition mediated by self-association results in rotation defects in the adult eye.
Loss of autoinhibition mediated by self-association results in severe eye defects including loss of R-cells.
In sing-22; myoblast fusion is abolished and consequently multinucleated myofibers fail to form during embryonic muscle development.
In sing-23; myoblast fusion is abolished and consequently multinucleated myofibers fail to form during embryonic muscle development.
In sing-27; myoblast fusion is abolished and consequently multinucleated myofibers fail to form during embryonic muscle development.
Uncharacterized Golgi apparatus membrane protein-like protein CG5021
In strain: MEL14, ZBMEL82, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398.
In strain: MEL14, ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL229, ZBMEL377 and ZBMEL398.
In strain: ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL229, ZBMEL377 and ZBMEL398.
RNA polymerase II transcriptional coactivator
Leucine-rich repeat protein soc-2 homolog
Stellate protein CG33236/CG33240/CG33244/CG33245
Probable H/ACA ribonucleoprotein complex subunit 1
Probable cytochrome P450 12a4, mitochondrial
Conserved oligomeric Golgi complex subunit 8
Glyceraldehyde-3-phosphate dehydrogenase 2
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
For poly [ADP-ribose] polymerase activity
In dbtL; lengthens the behavioral period.
In dbtS; shortens the behavioral period.
Probable ATP-dependent RNA helicase pitchoune
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Transcription initiation factor TFIID subunit 7
Glycine-rich cell wall structural protein 1.8-like
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Cytosolic Fe-S cluster assembly factor NUBP2 homolog
Circadian clock-controlled protein daywake
In strain: Oregon-R, wi4, wi15, wi6, wi24, wi30, wi32 and wi33.
CTD nuclear envelope phosphatase 1 homolog
Abolishes phosphorylation by Pink1 and reduces enzyme activity. Mitochondrial morphology and function is relatively normal however, expression in TH-neurons results in impaired flying ability, impaired dopamine release and an age-dependent loss of DA neurons, spherical clustering of mitochondria in DA neurons and disturbed mitochondrial transport. Able to rescue all mitochondrial and behavioral defects caused by the loss of Pink1. Partially rescues mitochondrial morphology and abnormal wing posture caused by loss of park. No effect on translocation to mitochondria.
Abolishes self-ubiquitination resulting in decreased E3 ligase activity.
Fails to rescue mitochondrial abnormalities and increases apoptosis in null mutants.
Loss of monoubiquitination and polyubiquitination of porin.
Phosphomimetic mutant with increased enzyme activity. Lethal when ubiquitously expressed. Constitutive phosphorylation results in impaired motor activity and fragmented mitochondria, likely due to reduced levels of the outer mitochondrial membrane proteins Marf and Miro. Expression in TH-neurons results in impaired flying ability, impaired dopamine release and substantial loss of DA neurons in very young adults (5-day old), single large mitochondria in each DA neuronal cell and loss of mitochondrial transport. Able to rescue reduced adult survival caused by loss of Pink1.
Reduced mitochondrial localization in the presence of Pink1. Reduced rescue of mitochondrial defects when expressed in null mutants.
Mitochondrial import inner membrane translocase subunit Tim16
Retinoblastoma-binding protein 5 homolog
Mediator of RNA polymerase II transcription subunit 6
V-type proton ATPase 16 kDa proteolipid subunit c
Transcription initiation factor TFIID subunit 10b
Sodium/potassium-transporting ATPase subunit beta-1
Choline O-acetyltransferase 13 kDa chain
Choline O-acetyltransferase 54 kDa chain
Choline O-acetyltransferase 67 kDa chain
Nedd8-activating enzyme E1 catalytic subunit
Abolishes binding with Rab6 and decreased binding with Sas-6.
Abolishes binding with Rab6. No effect on binding to Sas-6.
Decreased binding with Sas-6 and abolishes homodimerization. Loss of localization to the Golgi and centrosomes. Results in female sterility and loss of coordination.
Loss of localization to the Golgi and centrosomes. Results in female sterility and loss of coordination.
Loss of localization to the Golgi while retaining localization to the centrosomes.
Loss of localization to the Golgi while retaining localization to the centrosomes. No effect on binding with Sas-6.
Pheromone-binding protein-related protein 6
In stil-1; induces female infertility due to germ ovary defects.
In stil-2; induces female infertility due to germ ovary defects. Loss of chromatin association.
In stil-4; induces female infertility due to germ ovary defects. Loss of chromatin association.
Moderate decrease in catalytic activity but strongly reduces affinity for substrates I-Tyr and I2-Tyr.
Moderate decrease in catalytic efficiency and reduced affinity for substrates I-Tyr and I2-Tyr.
Significant decrease in catalytic efficiency and reduced affinity for substrates 3-iodo-L-tyrosine (I-Tyr) and 3,5-diiodo-L-tyrosine (I2-Tyr). Larvae survival is decreased when fed a diet supplemented with 100 or 200um of I-Tyr but is increased when fed a diet enriched with 3-chloro-L-tyrosine (Cl-Tyr). However, adult survival is unaffected when fed a diet supplemented with halotyrosines.
In esc1; induces homeotic transformation; when associated with F-64.
In esc1; induces homeotic transformation; when associated with R-240.
Strongly reduces phosphorylation and the interaction with E(z).
Transcription initiation factor TFIID subunit 12
Probable cytochrome P450 12d1 distal, mitochondrial
Probable mitochondrial import inner membrane translocase subunit Tim17 1
Cytosolic Fe-S cluster assembly factor NUBP1 homolog
Conserved oligomeric Golgi complex subunit 2
In AR66; slower channel activation and reduction of peak current.
Voltage-dependent calcium channel type D subunit alpha-1
Protein tumorous imaginal discs, mitochondrial
Serine/threonine-protein phosphatase PP2A
Replication protein A 70 kDa DNA-binding subunit
Hemolymph juvenile hormone binding protein
26S proteasome non-ATPase regulatory subunit 5
Mitochondrial ribonuclease P protein 1 homolog
Nedd8-activating enzyme E1 regulatory subunit
Testis-specific zinc finger protein topi
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
In isoform 1, isoform C, isoform G and isoform H.
Mediator of RNA polymerase II transcription subunit 23
Abolishes function in photoreceptor cell development.
Eukaryotic translation initiation factor 6
CBY1-interacting BAR domain-containing protein homolog
Protein-cysteine N-palmitoyltransferase Rasp
Neither inactivation nor afterpotential protein C
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Leucine-rich repeat and calponin homology domain-containing protein
Cytochrome c oxidase assembly factor 3, mitochondrial
Transport and Golgi organization protein 6
Probable 28S ribosomal protein S16, mitochondrial
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
Low molecular weight phosphotyrosine protein phosphatase 1
Guanine nucleotide-binding protein subunit beta-2
Probable cleavage and polyadenylation specificity factor subunit 2
General transcription factor IIF subunit 2
Transport and Golgi organization protein 11
Putative lipoyltransferase 2, mitochondrial
Histone-lysine N-methyltransferase Su(var)3-9
In cdc2-D57; embryonic or larval-pupal lethal.
In cdc2-E1-24; larval-pupal lethal with some adult escapers.
In cdc2-E1-4; larval-pupal lethal with some adult escapers.
Eukaryotic translation initiation factor 3 subunit F-2
Eukaryotic translation initiation factor 2-alpha kinase
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Results in zinc-elicited currents with increased rise time and deactivation kinetics in Xenopus oocytes; when associated with F-296.
Results in zinc-elicited currents with increased rise time and deactivation kinetics in Xenopus oocytes; when associated with K-255.
In DLis8.25.3; induces defects in nuclear migration.
In Lis1-23F2; induces lethality in second instar larvae.
Potential E3 ubiquitin-protein ligase ariadne-2
26S proteasome non-ATPase regulatory subunit 11
Underreplication is suppressed in larval salivary glands.
U5 small nuclear ribonucleoprotein 200 kDa helicase
Succinate dehydrogenase assembly factor 2-B, mitochondrial
Probable cardiolipin synthase (CMP-forming)
Ubiquitin-conjugating enzyme E2Q-like protein CG4502
Reduces palmitoylation. Loss of palmitoylation; when associated with A-120 and A-147.
Reduces protein stability and palmitoylation. Loss of palmitoylation; when associated with A-120 and A-147.
In strain: DI7, Draveil, KY024, KY038, Loua, Monty5 and ZW141.
In strain: DI7, Draveil, KY024, KY038, Loua, Monty5, Tahiti and ZW141.
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Mild reduction in interaction with eIF4E1. Complete loss of interaction with eIF4E1; when associated with A-327 and A-364.
Mild reduction in interaction with eIF4E1. Complete loss of interaction with eIF4E1; when associated with A-327 and A-368.
Reduction in interaction with eIF4E1. Strong reduction in interaction with eIF4E1; when associated with A-327.
Strong reduction in interaction with eIF4E1. Strong reduction in interaction with eIF4E1; when associated with A-332 and A-348. Complete loss of interaction with eIF4E1; when associated with A-364 and A-368.
Fork head domain-containing protein crocodile
Proton acceptor; for glutaminase activity
In strain: NC336, NC358, NC361, NC362 and NC375.
Dehydrogenase/reductase SDR family protein 7-like
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Shows resistance to picrotoxin-induced activity inhibition.
Heterogeneous nuclear ribonucleoprotein 27C
In strain: ZBMEL84, ZBMEL95, ZBMEL131 and ZBMEL157.
28S ribosomal protein S15, mitochondrial
Glutaredoxin domain-containing cysteine-rich protein CG31559
No effect on methionine sulfoxide reductase activity and still lacks methionine oxidase activity; when associated with S-232.
No effect on methionine sulfoxide reductase activity and still lacks methionine oxidase activity; when associated with S-246.
DNA polymerase subunit gamma-2, mitochondrial
Loss of mitochondrial DNA which disrupts mitochondrial morphology; larval brains are smaller due to defective cell proliferation leading to death at the pupal stage.
General transcription factor IIF subunit 1
Transcription initiation factor IIA alpha chain
Transcription initiation factor IIA beta chain
Transcription initiation factor IIA subunit 1
Chromodomain-helicase-DNA-binding protein Mi-2 homolog
Molybdopterin synthase catalytic subunit
20-fold increase in levels of mitotic recombination, very limited 3'-5' exonuclease activity.
Completely lacks exonuclease activity, when associated with A-162.
Completely lacks exonuclease activity, when associated with A-164.
Causes accumulation exclusively in the cytoplasm.
In ninaB(P315); abolishes catalytic activity.
Loss of zinc fingers domains results in defects in cuticle elasticity, reduced sclerotization of the head skeleton and ventral epidermal denticles, and disruption of multiple aspects of tube morphogenesis in terminal cells including seamless tube growth, shape, and integrity.
Probable loss of zinc ion coordination in the second zinc finger results in defects in cuticle elasticity, reduced sclerotization of the head skeleton and ventral epidermal denticles, and disruption of multiple aspects of tube morphogenesis in terminal cells including seamless tube growth, shape, and integrity.
Abolishes activity and autophosphorylation. Fails to recruit park to mitochondria.
Loss of kinase activity and impaired recruitment of park to mitochondria. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-501.
Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with A-479 and A-501.
Loss of kinase activity. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-479.
No effect on activity and autophosphorylation.
Phosphomimetic mutant; no effect on activity and promotes translocation of park to mitochondria.
Serine/threonine-protein kinase Pink1, mitochondrial
Loss of activity in Myc-mediated growth in the wing and eye, and no increase in the expression of CycE in the wing imaginal disk when overexpressed. Unable to increase expression of Myc and ago in the wing imaginal disk when overexpressed; when associated with A-2305 and A-2328.
Loss of activity in Myc-mediated growth in the wing and eye, and unable to increase expression of Myc and ago in the wing imaginal disk when overexpressed; when associated with A-2024 and A-2305.
Loss of activity in Myc-mediated growth in the wing and eye, and unable to increase expression of Myc and ago in the wing imaginal disk when overexpressed; when associated with A-2024 and A-2328.
Ubiquitin carboxyl-terminal hydrolase puf
Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Mediator of RNA polymerase II transcription subunit 17
Abrogates enhancement of gypsy chromatin insulator activity.
Abrogates ubiquitin-protein E3 ligase activity.
Serine--tRNA synthetase-like protein Slimp
Differentially expressed in FDCP 8 homolog
Biogenesis of lysosome-related organelles complex 1 subunit 6
Eukaryotic peptide chain release factor subunit 1
V-type proton ATPase catalytic subunit A isoform 1
In Bwx; eyes are brown due to a reduction in red pigment production.
In Et87; 98% decrease in drosopterin (eye red pigment) levels and undetectable levels of xanthommatin (eye brown pigment).
In cf; 70% decrease in drosopterin (eye red pigment) levels, 36% decrease in xanthommatin (eye brown pigment) levels and severe defect of copulation success; when associated with E-589.
In cf; 70% decrease in drosopterin (eye red pigment) levels, 36% decrease in xanthommatin (eye brown pigment) levels and severe defect of copulation success; when associated with R-49.
In co2; normal eye color. Eyes are brown due to a reduction in red pigment production in a bw/brown 6 or T50 mutant background.
In crr; 89% decrease in drosopterin (eye red pigment) levels and 81% decrease in xanthommatin (eye brown pigment) levels.
In sat; 96% decrease in drosopterin (eye red pigment) levels and 21% decrease in xanthommatin (eye brown pigment) levels.
Putative inner dynein arm light chain, axonemal
In 2S-A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-48.
In 2S-A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-52.
In 2S-D; phosphomimetic mutant that displays reduced cortical localization but no significant decrease in phospholipid binding; when associated with D-48.
In 2S-D; phosphomimetic mutant that displays reduced cortical localization but no significant decrease in phospholipid binding; when associated with D-52.
In 4R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with D-46 and D-47.
In 4R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with D-54 and D-55.
Loss of binding affinity to Nak and drop in binding to single helical peptide.
Loss of binding affinity to Nak and single helical peptide.
Reduced cortical localization and increased cytoplasmic localization.
Slight reduction in cortical localization.
In Fez-1; Reduced protein stability resulting is abnormal expansion of Type II neuroblast lineage due to dedifferentiation of intermediate neuronal progenitors (INPs). In lamina L3 neurons, growth cones display defects in morphology and incorrect targeting to the proximal domain of the outer medulla. Reduced expression of cell surface proteins dpr17 and dpr1 as well as the netrins NetA and NetB in L3 neurons. No effect on L3 dendrite branching and M3 layer innervation of Tm9 neurons.
In strain: AF2, AF7, Au4, La3, La15, La37, La58, Ma21, Mo29b, Mo36a, Mo52B, Mo79b, NC-009, Ny3, Ny5 and TW11.
In strain: AF5, AF10, Au5, La3, La15, La105, Mo36a, Mo37a, Mo47a, Mo79b and TW10.
In strain: AF6, AF8, AF9, Au4, La31, La32, La60, La125, Ma6, Ma21, Ma57, TW1 and TW11.
Males have no visible phenotype and are fertile. However, mated females display a decrease in the number of oocytes released by their ovary and deposit fewer eggs on day 1 after the start of mating (ASM). No effect on the number of eggs laid by mated females on day 2 to 4 ASM. No effect on female receptibility to another mate and does not affect sperm resistance to displacement by rival ejaculates.
Abolished E3 ubiquitin-protein ligase activity and ability to generate large endosomes when overexpressed.
Hairy/enhancer-of-split related with YRPW motif protein
RNA-binding protein Musashi homolog Rbp6
Probable DNA mismatch repair protein Msh6
Conserved oligomeric Golgi complex subunit 4
Probable ATP-dependent RNA helicase Dbp45A
In KRm12; lethal due to lower enzyme activity; when associated with S-97.
In KRm4; lethal due to loss of catalytic activity; when associated with S-97.
In KRm5; lethal due to loss of phosphorylated active site intermediate; when associated with S-97.
In KRm7; lethal due to loss of phosphorylated active site intermediate; when associated with S-97.
In KRm9; lower enzyme activity; when associated with S-97.
In KRn3; lethal due to loss of phosphorylated active site intermediate; when associated with S-97.
Killer of prune mutation. Conditionally dominant lethal mutation in individuals with a null mutation in the prune gene.
PAN2-PAN3 deadenylation complex subunit PAN3
39S ribosomal protein L22, mitochondrial
Enhancer of yellow 2b transcription factor
Asymmetric dimethylarginine; by autocatalysis
Probable histone-arginine methyltransferase CARMER
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
In isoform Female-E, isoform K and isoform Male-E.
In isoform Female-I, isoform Female-A, isoform Type-D, isoform Type-C, isoform Female-B and isoform Female-E.
In isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B.
In rumi-79; complete loss of enzyme activity.
Nearly complete loss of enzyme activity.
Transient receptor potential-gamma protein
Mitochondrial import inner membrane translocase subunit Tim13
WD repeat-containing protein on Y chromosome
In car-1; irregular clustering of early endosomes; when associated with V-249.
In car-1; irregular clustering of early endosomes; when associated with V-26.
Vacuolar protein sorting-associated protein 33A
Transcription factor kayak, isoforms A/B/F
Transcription factor kayak, isoforms D/sro
Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog
Eukaryotic translation initiation factor 4E transporter
In strain: KY02-C331, KY02-C392 and Oregon-R.
Glycylpeptide N-tetradecanoyltransferase
DnaJ homolog subfamily C member 5 homolog
Small conductance calcium-activated potassium channel protein
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
In allele K1214; eggs exhibit thin shell and flimsy dorsal appendages.
Slihgtly reduces complex helicase activity.
During cellularization, unable to rescue increased ring constriction in Graf-CR57 mutants.
In Graf-CR57; semi-embryonic lethal, with 71% of embryos dying at 24 hr. Displays cellularization defects including the loss of polygonal F-actin architecture and premature actomyosin ring formation during early cellularization, and enhanced ring constriction during mid and late cellularization. Nuclei also have a bottleneck appearance likely due to the premature ring constriction at the furrow canal tip the mid cellularization stage.
Transient receptor potential cation channel trpm
Probable G-protein coupled receptor Mth-like 14
In strain: MW25, MW38, MW56, MW63, MW9, NC304, NC357 and NC361.
In strain: MW6, MW27, NC301, NC304 and NC397.
In z5864; Induces 4th chromosome non-disjunction.
Circadian locomoter output cycles protein kaput
No effect on the catalytic activity towards tryptamine.
Reduces catalytic activity towards tryptamine.
Greatly reduced autoprocessing activity.
N-product is made but fails to undergo palmitoylation.
Transmembrane emp24 domain-containing protein eca
Ribosome quality control complex subunit NEMF homolog
In Z3-0437; induces female and male sterility and abolishes T-119 phosphorylation of H2A in the oocyte.
In D57; induces head-like skeletal structures in the trunk.
In E9; induces head-like skeletal structures in the trunk.
In allele inaD-P215; slow recovery of light-induced responses and altered light sensitivity. Abolishes interaction with trp.
Inactivation-no-after-potential D protein
Nearly 2-fold increase in interaction with inaC.
Over 3-fold increase in interaction with inaC.
Slight reduction in interaction with inaC.
Transcription factor glial cells missing
Protein transport protein Sec61 gamma-1 subunit
Lateral signaling target protein 2 homolog
Phosphatidylinositol-glycan biosynthesis class X protein
EF-hand domain-containing protein D2 homolog
Piezo-type mechanosensitive ion channel component
In strain: ZBMEL131, ZBMEL157, ZBMEL186 and ZBMEL191.
In strain: ZBMEL131, ZBMEL186, ZBMEL229, ZBMEL377 and ZBMEL398.
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Putative gamma-glutamylcyclotransferase CG2811
39S ribosomal protein L52, mitochondrial
In QW55; abnormal arrest in female meiosis.
In RH65; abnormal arrest in female meiosis.
Prevents degradation following egg activation.
Abolishes phosphatase activity. Loss of bsk/JNK binding. Reduced nuclear localization.
Dual specificity protein phosphatase MPK-4
DNA-directed RNA polymerase I subunit RPA1
Fails to be recruited at the membrane upon activation.
Zinc finger TRAF-type-containing protein 1 homolog
Gastrulation defective protein 1 homolog
Causes inverted left-right asymmetry of the midgut and hindgut in embryos and adults. Flies are viable and fertile, but display mildly reduced hatching rate and reduced life span.
Loss of function in specification of gut left-right asymmetry.
Loss of function in specification of gut left-right asymmetry; when associated with A-106 and A-156.
Loss of function in specification of gut left-right asymmetry; when associated with A-106 and A-382.
Loss of function in specification of gut left-right asymmetry; when associated with A-155 and A-382.
Loss of the ability to promote the normal dextral looping of the spermiduct.
ATPase H(+)-transporting accessory protein 2
ATPase H(+)-transporting accessory protein 2 C-terminal fragment
ATPase H(+)-transporting accessory protein 2 N-terminal fragment
Lethal in the late larval stage with few adult escapers showing poor mobility, decreased or absent climbing capabilities, blistered wings, reduced head size and death within 3-4 days after eclosion. Impairs localization to the endoplasmic reticulum, enhances cleavage and protein stability.
Prevents cleavage; when associated with A-248.
Prevents cleavage; when associated with A-251.
Reduces protein stability and increases N-glycosylation levels of proteins which targets the misfolded protein to degradation. Impairs autophagy and mTOR signaling. Reduces eclosion rate with few adult escapers showing poor mobility, decreased or absent climbing capabilities, blistered winds and reduced size and death within 3-4 days. In the brain, results in neural development defects in the optic lobe. In the fat body, increases lipid droplets size and total triglycerides.
Survive till late pupal stage. Impairs localization to the endoplasmic reticulum and autophagy degradation. In the fat body, increases lipid droplets size and total triglycerides.
Leucine-zipper-like transcriptional regulator 1 homolog
Mediator of RNA polymerase II transcription subunit 26
Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-828 and A-1119.
Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-107. In larp-10A, loss of phosphorylation by Pink1; when associated with A-107; A-182; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-182. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-186. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-66. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-182; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues nascent protein synthesis and PolG1 expression in mitochondria containing deleterious mutations. Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-828 and 1510-A-A-1512.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-107.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-182.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-186.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-66.
Phosphomimetic mutant, severe reduction in ability to rescue mtDNA levels and hatching rate in spoon null mutants.
Endonuclease_NS domain-containing protein
In isoform D, isoform L, isoform O, isoform R and isoform W.
In isoform L, isoform E, isoform O and isoform R.
In isoform S, isoform U, isoform W, isoform X and isoform V.
Interchain (between heavy and light chains)
Cytoplasmic phosphatidylinositol transfer protein 1
Serine/threonine-protein phosphatase rdgC
Probable V-type proton ATPase subunit d 2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Enhancer of mRNA-decapping protein 4 homolog
In strain: DPF; induces a high-diapause phenotype.
DNA-directed RNA polymerase II subunit RPB11
Partial loss of DNA-binding and significant decrease in transcriptional repressor activity. Complete loss of repressor activity; when associated with A-354.
Partial loss of DNA-binding and transcriptional repressor activity.
Significant loss of DNA-binding and transcriptional repressor activity. Complete loss of repressor activity; when associated with A-351.
Enhancer of yellow 2 transcription factor
In isoform 11.15, isoform 11.27 and isoform 11.7.
In isoform 8.24, isoform 11.32 and isoform 11.6.
Not cleaved when expressed with activated SPE.
Abolishes interaction with wg and causes significant reduction of 100 kDa form which is likely to be the heparan sulfate-modified form; when associated with A-287 and A-288.
Abolishes interaction with wg and causes significant reduction of 100 kDa form which is likely to be the heparan sulfate-modified form; when associated with A-331 and A-332.
S-adenosylmethionine sensor upstream of mTORC1
In Su(z)12-2; induces larval lethality; when homozygous.
Abnormal aggregation of Golgi apparatus and disrupted cleavage furrow ingression in early embryos. May be insensitive to Asap activation.
No defect in Golgi apparatus and cleavage furrow ingression in early embryos.
Zinc finger CCCH domain-containing protein 3
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
In allele GPDH-AT198, allele GPDH-ACB62 and allele GPDH-S.
Results in progressive degeneration of photoreceptors and glia that show accumulation of large lipid droplets. Results in reduced cell proliferation, up-regulation of the mitochondrial unfolded protein response and cell aberrant mitochondrial respiration leading to an increased oxidative stress.
Semi-viable with reduced cell proliferation and lifespan including progressive degeneration of photoreceptors and glia. Shows aberrant mitochondrial respiration probably leading to an increased oxidative stress. Shows high levels of reactive oxygen species (ROS) and accumulation of lipid droplets in pigment and epithelial glia. Lipid droplet accumulation occurs early, prior to the onset of neurodegeneration.
Decreased binding to piwi and unable to rescue fertility and transposon activation defects in mutants. Abolishes binding to piwi; when associated with A-328.
Significant decrease in binding to unmethylated piwi.
Tudor and KH domain-containing protein homolog
Unable to rescue fertility and transposon activation defects in mutants. Abolishes binding to piwi; when associated with R-348.
In esg[VS8]; 50-fold reduction of affinity for DNA binding.
Mediator of RNA polymerase II transcription subunit 30
In strain: Ann Arbor1, DP CN BW, Kakamega-b1, Kakamega-b3, Kakamega-b4, Kenya-HLa3, Kenya-HLa6, Makindu-b5 and Reids2.
In strain: Kenya-HLa3, Kenya-HLa6, Kakamega-b1 and Makindu-b1.
Inactive selenide, water dikinase-like protein
Putative polypeptide N-acetylgalactosaminyltransferase 10
Dual specificity mitogen-activated protein kinase kinase dSOR1
Probable E3 ubiquitin-protein ligase HERC2
Coiled-coil and C2 domain-containing protein 1-like
Microsomal triacylglycerol transfer protein
Biogenesis of lysosome-related organelles complex 1 subunit 1
Vesicular, overexpressed in cancer, prosurvival protein 1
JmjC domain-containing histone demethylation protein 1
39S ribosomal protein L23, mitochondrial
Ubiquitin carboxyl-terminal hydrolase nonstop
Acetylcholine receptor subunit alpha-like 1
Does not affect subcellular location or interaction with Rab11. Fails to inactivate Rab11.
Ecotropic viral integration site 5 ortholog
Inhibits binding to Cdc42; when associated with L-19.
Inhibits binding to Cdc42; when associated with L-22.
Strongly reduces autophosphorylation and substrate phosphorylation.
Increase in late endosome size. Loss of binding to various phosphoinositides, but no loss of binding to phosphatidylinositol 3-phosphate (PtdIns3P). Localization to the cell cortex and endosomes is not affected.
No localization to the endosomes. Present at the plasma membrane and in the cytosol. Loss of binding to PtdIns3P.
Pleckstrin homology domain-containing family F member 1 homolog
Abolishes phosphorylation by Akt1, nuclear localization, and transcriptional activity.
In isoform A, isoform B, isoform C and isoform E.
Malpighian tubules empty into a single large sack that is attached to the hindgut and no ureters are evident. Distal segments of the tubules are tubular but fail to elongate or undergo cell rearrangement, resulting in tubules that are shorter and wider than normal. Hindguts are normal in shape but shortened.
No effect on phosphorylation by Akt1; no effect on transcriptional activity.
Slightly increases transcriptional activity.
Probable cytochrome P450 12d1 proximal, mitochondrial
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
Phosphoribosylformylglycinamidine synthase
Reduces nuclear aCCumulation in ovary and ovarian somatic cells. Affects transposable element silencing. Causes female sterility.
Does not affect acetyltransferase activity.
Reduced acetyltransferase activity; when associated with A-46.
Reduced acetyltransferase activity; when associated with A-53.
Reduced acetyltransferase activity; when associated with A-83.
Reduced acetyltransferase activity; when associated with A-98.
Ubiquitin carboxyl-terminal hydrolase 30 homolog
General transcription and DNA repair factor IIH helicase subunit XPB
Intraflagellar transport protein 57 homolog
Abolishes enzymatic activity; when associated with A-534.
Abolishes enzymatic activity; when associated with A-536.
tRNA-uridine aminocarboxypropyltransferase 2
Chromatin modification-related protein MEAF6
Impaired cell cycle arrest in response to the DNA synthesis inhibitor hydroxyurea (HU).
Probable cytochrome P450 12b2, mitochondrial
Nuclear localization and induces transcriptional activity; when associated with A-527.
Nuclear localization and induces transcriptional activity; when associated with A-530.
In strain: MB01a, MB08b, MB29b, MB36a, MB45b, MB47a, MB48b and MB52b and MB80b.
In strain: MB08b, MB15b, MB25a, MB29b, MB33a, MB34a, MB36a, MB39b, MB45b, MB46b, MB47a, MB48b, MB52b, MB58b, MB63a and MB80b.
In strain: MB08b, MB29b, MB36a, MB40b, MB47a, MB48b, MB52b and MB58b.
In strain: MB08b, MB29b, MB40b, MB45b, MB47a, MB48b, MB52b and MB80b.
In strain: MB13a, MB15b, MB25a, MB34a, MB37a and MB63a.
In allele MtnA-3 and strain: AF6, Highgrove, Indiana, LA20, Taiwan, ZH18, ZH21, ZH27, ZS11, ZS30 and ZS56.
ATP-dependent RNA helicase SUV3 homolog, mitochondrial
Facilitated trehalose transporter Tret1-1
Cysteine-rich DPF motif domain-containing protein 1
Mediator of RNA polymerase II transcription subunit 18
Bifunctional glutamate/proline--tRNA ligase
Mitochondrial import receptor subunit TOM40 homolog 2
Loss of nuclear location. Location is mainly cytoplasmic or diffuse.
In ORE119; defective in embryonic axon guidance.
In ORE120; defective in embryonic axon guidance.
Longitudinals lacking protein, isoform G
Longitudinals lacking protein, isoforms A/B/D/L
Longitudinals lacking protein, isoforms F/I/K/T
Longitudinals lacking protein, isoforms H/M/V
Longitudinals lacking protein, isoforms J/P/Q/S/Z
Longitudinals lacking protein, isoforms N/O/W/X/Y
NPC intracellular cholesterol transporter 1 homolog 1b
Probable methylthioribulose-1-phosphate dehydratase
Abolishes phosphorylation; when associated with A-190 and A-259.
Abolishes phosphorylation; when associated with A-44 and A-190.
Abolishes phosphorylation; when associated with A-44 and A-259.
Acetylcholine receptor subunit beta-like 1
U1 small nuclear ribonucleoprotein 70 kDa
Calcium-binding mitochondrial carrier protein Aralar1
Fails to inhibit growth. Loss of localization to apical membranes. Not necessary to modify src-induced overgrowth.
Fails to rescue the loss of terminal arborization in mechanosensory neurons in null flies.
ATPase family AAA domain-containing protein 3A homolog
Decreases the number of mitochondria in motor neurons or in body wall muscles.
Vacuolar protein sorting-associated protein 16B
Reduced specificity and affinity for DNA.
Segmentation polarity homeobox protein engrailed
Partially rescues muscle function and structure defects in the null mutant. Fails to interact with alpha-PS2/beta-PS.
Heterologous expression in salivary glands shows inhibition of calcium influx.
In allele DB25; defect in synaptic transmission and homozygous lethal.
Serine/threonine-protein phosphatase alpha-1 isoform
Mitochondrial inner membrane protease subunit 2
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2
TPM_phosphatase domain-containing protein
2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog
Mediator of RNA polymerase II transcription subunit 21
In isoform 11b, isoform BDBBA, isoform L and isoform M.
In isoform 11c, isoform C, isoform D and isoform I.
In isoform 11d, isoform BABDB, isoform E, isoform G, isoform H and isoform Q.
In isoform 15b, isoform BABDB, isoform C, isoform D, isoform E, isoform F, isoform G, isoform H, isoform I and isoform Q.
In isoform 18, isoform K, isoform L and isoform M.
In isoform 3b, isoform BDBBA, isoform BABDB, isoform D, isoform F, isoform H, isoform I, isoform K, isoform L and isoform M.
In isoform 7d, isoform BDBBA, isoform K, isoform L and isoform M.
In isoform 9b, isoform BDBBA, isoform BABDB, isoform C, isoform D, isoform F, isoform G, isoform Q and isoform M.
In isoform 9c, isoform E, isoform H and isoform I.
In allele scra1. Strong maternal effect allele; abrogates cellularization of syncytial embryos.
In allele scra3. Weak maternal effect allele; abrogates separation of pole cells.
In allele scra4. Strong maternal effect allele; abrogates cellularization of syncytial embryos.
In allele scra5. Strong maternal effect allele; abrogates cellularization of syncytial embryos.
In alleles scra1; scra3; scra4; and scra5.
Results in reduced viability, shortened lifespan, age-dependent wing posture and locomotor defects. Results in increased steady-state levels of specific neuronal mRNAs such as Arc1 and wfs1.
Results in reduced viability, shortened lifespan, age-dependent wing posture and locomotor defects. Shows a mushroom body beta-lobe midline-crossing defect. Results in increased steady-state levels of specific neuronal mRNAs such as Arc1 and wfs1.
Transcription factor glial cells missing 2
Arylalkylamine N-acetyltransferase-like 2
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Multiple C2 and transmembrane domain-containing protein
Glycosyltransferase-like domain-containing protein 1-like
In allele shd-Z383; failure of head involution. Defects in dorsal closure and aberrant gut looping.
Mediator of RNA polymerase II transcription subunit 4
Ribosomal RNA small subunit methyltransferase NEP1
Cleavage and polyadenylation specificity factor subunit 4
Induces the formation of microtubule-rich protrusions. Abolishes repression of Yki. Causes an isoform A-like cellular phenotype with development of filopodia-like structures.
ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein
Translation factor waclaw, mitochondrial
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Conserved oligomeric Golgi complex subunit 7
Rab proteins geranylgeranyltransferase component A
DNA methyltransferase 1-associated protein 1
Chromosomal serine/threonine-protein kinase JIL-1
Severely diminishes UTP inhibition of CPSase; in Su(b).
Greatly reduces sev binding and sev signaling.
Loss of conjugation of target proteins results in loss of urmylation and response to oxidative stress.
Impairs autoinhibition; when associated with A-377 and A-378. Loss of activity and impaired autoinhibition; when associated with A-377; A-378 and S-304.
Impairs autoinhibition; when associated with A-377 and A-450. Loss of activity and impaired autoinhibition; when associated with A-377; A-450 and S-304.
Impairs autoinhibition; when associated with A-378 and A-450. Loss of activity and impaired autoinhibition; when associated with A-378; A-450 and S-304.
In ari-1a; Loss of catalytic activity. Late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects, likely due to the mislocalization of the LINC complex. Reduced degradation of the LINC complex member koi.
In ari-1b; Loss of catalytic activity. Late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects, likely due to the mislocalization of the LINC complex; when associated with E-187.
In ari-1b; Loss of catalytic activity. Late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects, likely due to the mislocalization of the LINC complex; when associated with P-332.
In ari-1d; late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects.
In ari1-2; lethal phenotype and loss of interaction with Ubc10.
In ari1-3; lethal phenotype and no loss of interaction with Ubc10.
Loss of catalytic activity and impaired autoinhibition; when associated with A-377; A-378 and A-450.
In strain: isofemale line 31, isofemale line 32, isofemale line 68, La14, La14, La16, La35, M01, M06, M09, M12, M26, M47, Ma5, Ma7, Ma13, Ma18, Ma20, Ma21, Ma45, Ma48, Ma50, Ma52, Ma67, Mo2b, Mo15b, Mo34a, Mo36a, Mo37a, Mo47a, Mo52b, Mo58b, Mo80b, NFS 5.1, NFS 5.2, NFS 5.4, NFS 6.2, NFS 6.3, NFS 6.4, SFS 1.1, SFS 1.3, SFS 1.4, SFS 2.2, SFS 3.1, SFS 3.3, WS1, WS6, WS9, WS12, WS16, WS26, WS47, WS56, Zim2, Zim26, Zim29, Zim30, Zim32, Zim37, Zim42 and Zim56.
In strain: isofemale line 32, La1, La3, La4, La5, La14, La15, La16, La21, La25, La34, La35, M18, Ma5, Ma8, Ma13, Ma18, Ma20, Ma21, Ma45, Ma48, Ma52, Ma67, Mo1b, Mo52b, Mo80b, NFS 6.1, SFS 1.2, WS6, WS19, Zim26, Zim29, Zim30 and Zim56.
VPS35 endosomal protein sorting factor-like
Inactive non-canonical poly(A) RNA polymerase protein Trf4-2
In allele sub-1794; elevated levels of X chromosome non-disjunction.
In allele sub-Dub; meiotic non-disjunction in males and females.
Interchain (between non-catalytic and catalytic chains)
Serine proteinase stubble catalytic chain
Serine proteinase stubble non-catalytic chain
Probable Golgi SNAP receptor complex member 2
Lack of GTP-binding, defective light-induced internalization of TRPL, late-onset light-dependent photoreceptor degeneration and larval lethality.
Tyrosine-protein phosphatase non-receptor type 61F
Cysteine sulfinic acid (-SO2H); alternate
Probable small nuclear ribonucleoprotein E
Disrupts the SH2 domain. Does not affect binding to Dab.
Disrupts the SH3 domain. Abolishes binding to Dab; when associated with L-49.
In E(sev)2B mutant; ommatidial cell development obstruction.
In Su(sevs11)R1 mutant; ommatidial cell development obstruction.
Inactivates the SH3 domain. Abolishes binding to Dab; when associated with R-199.
Increases the stability of the SH3 1 domain.
Impaired ability to inhibit the Wnt signaling pathway.
Palmitoleoyl-protein carboxylesterase NOTUM
26S proteasome non-ATPase regulatory subunit 9
Eukaryotic translation initiation factor 2 subunit 2
Zinc finger FYVE domain-containing protein 26 homolog
In allele sim-J1-47; temperature sensitive embryonic midline axon phenotype.
Transport and Golgi organization protein 2
DNA repair protein complementing XP-C cells homolog
Transcription initiation factor TFIID subunit 8
Abolishes RNA binding without altering the conformation of the domain.
Affects RNA binding without altering the conformation of the domain.
Mitochondrial import inner membrane translocase subunit Tim10B
O-linked (Xyl...) (glycosaminoglycan) serine
Probable cytochrome P450 301a1, mitochondrial
Nitrilase and fragile histidine triad fusion protein NitFhit
Forms round eggs. Intracellular vkg accumulates at the basal surface of follicle cells, and vkg levels are reduced in the basal membrane.
Procollagen-lysine,2-oxoglutarate 5-dioxygenase
Probable 39S ribosomal protein L45, mitochondrial
Phosphatidylserine amidated glycine; alternate
Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog
N-acetylcysteine; in Chorion peroxidase light chain
Endocuticle structural glycoprotein SgAbd-2
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
eEF1A lysine and N-terminal methyltransferase homolog
Loss of catalytic activity. Abolishes formation of linear polyubiquitin chains, slight reduction in longevity and upon heat shock, adults display reduced induction of Hsp70 and thus a reduction in heat stress tolerance. No obvious effect on adult phenotype and no reduction in immunity to E.coli infection; when associated with S-2690.
Loss of catalytic activity. Abolishes formation of linear polyubiquitin chains, slight reduction in longevity and upon heat shock, adults display reduced induction of Hsp70 and thus a reduction in heat stress tolerance. No obvious effect on adult phenotype and no reduction in immunity to E.coli infection; when associated with S-2693.
Reduces formation of linear polyubiquitin chains, slight reduction in longevity and upon heat shock adults display reduced induction of Hsp70 and thus a reduction in heat stress tolerance. No obvious effect on adult phenotype and no reduction in immunity to E.coli infection.
Reduces formation of linear polyubiquitin chains.
Reduces formation of linear ubiquitin chains.
Abolishes nucleosome mobilization. Retains ATPase activity but is unable to bind DNA or mononucleosomes.
Chromodomain-helicase-DNA-binding protein 3
No effect on ATPase activity or nucleosome mobilization, and is able to bind DNA and mononucleosomes.
Induces a fourfold reduction in interaction with sina and impairs ttk degradation.
Induces a twofold reduction in interaction with sina and impairs ttk degradation.
No effect in interaction with sina or ttk degradation.
NAD-dependent histone deacetylase sirtuin-1
Mitochondrial import inner membrane translocase subunit Tim8
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
No effect on double-stranded DNA cleavage. Strong decrease in ATPase activity and strand passage activity.
O-(5'-phospho-DNA)-tyrosine intermediate
Does not rescue the phenotype of Pink1-null mutants which are unable to maintain neurotransmitter release at neuromuscular junctions (NMJ) during high-frequency stimulation (10 Hz). Rescues the climbing deficit of Pink1-null mutants.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Rescues some phenotypes of Pink1-null mutants by re-enabling maintained neurotransmitter release at neuromuscular junctions (NMJ) during high-frequency stimulation (10 Hz), by restoring mitochondria cristae structural organization and by improving climbing activity; does not restore muscle morphology and rescues only partially flight defects in the same mutants.
Loss of function; when associated with 516-A-A-517.
Loss of function; when associated with 517-N-N-517.
Loss of function; when associated with A-1030.
Loss of function; when associated with N-1030.
Mitochondrial import inner membrane translocase subunit Tim22
39S ribosomal protein L34, mitochondrial
In 8B12; death primarily during embryogenesis and early larval stages with no obvious cuticle patterning defects.
Multifunctional methyltransferase subunit TRM112-like protein
In strain: OK17, OK94, Z42, Z55, Z64 and Z74.
Fork head domain transcription factor slp2
TATA box-binding protein-associated factor RNA polymerase I subunit B
PP2C-like domain-containing protein CG9801
In strain: Berkeley, L18, Oregon-R, SP1 and U79.
Transcription initiation factor TFIID subunit 1
Nuclear receptor-binding protein homolog
Platelet-activating factor acetylhydrolase IB subunit beta homolog
Abolishes deubiquitinase activity without affecting the interaction with Asx.
Ubiquitin carboxyl-terminal hydrolase calypso
Juvenile hormone acid O-methyltransferase
Abolishes binding to CBX5; when associated with A-30.
Abolishes binding to CBX5; when associated with or without A-130. Fails to rescue dominant defects in white reporter silencing produced by the piwi2 mutation.
Abolishes binding to piRNAs. Reduces localization to the nucleus. Does not affect chromatin binding. Affects fertility and ovary morphology.
Confers RNAi insensitivity; when associated with G-54.
Confers RNAi insensitivity; when associated with P-67.
Does not affect nuclear localization, repression activity of soma- and germline-specific transposable elements, fertility and piRNA loading; when associated with or without A-614.
Does not affect nuclear localization, repression activity of soma- and germline-specific transposable elements, fertility and piRNA loading; when associated with or without A-685.
Highly significant decrease in binding to papi.
Largely prevents nuclear accumulation. Affects repression activity of soma- and germline-specific transposable elements and fertility.
No significant effect on binding to papi.
28S rRNA (cytosine-C(5))-methyltransferase
Ribosome biogenesis protein BRX1 homolog
Mesencephalic astrocyte-derived neurotrophic factor homolog
Probable G-protein coupled receptor Mth-like 6
Eukaryotic translation initiation factor 2 subunit 3
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-679 and A-766.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-679, and A-1103.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-766 and A-1103.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-679, A-766 and A-1103.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-423, A-679, A-766 and A-1103.
Reduced female fertility caused by perturbed oogenesis which includes chorion defects and general ovariole disintegration due to apoptosis.
Transmembrane protein 70 homolog, mitochondrial
60 kDa heat shock protein homolog 2, mitochondrial
G patch domain-containing protein 1 homolog
Abolished phosphorylation by Cdk7, leading to increased ubiquitination by the DCX(DCAF12) complex.
Increased activity and nuclear localization and decreased sensitivity to Hpo/Wts-mediated inhibition; when associated with A-227.
Increased activity and nuclear localization and decreased sensitivity to Hpo/Wts-mediated inhibition; when associated with A-88.
Increased activity and nuclear localization, decreased sensitivity to Hpo/Wts-mediated inhibition, loss of interaction with 14-3-3epsilon and 14-3-3zeta.
Phosphomimetic mutant; decreased ubiquitination by the DCX(DCAF12) complex.
Probable glucosamine 6-phosphate N-acetyltransferase
Extracellular superoxide dismutase [Cu-Zn]
In Muta; reduced iav expression in the cilia but is not required for lav or nompC localization in the cilia.
In Mutb; reduced iav expression in the cilia but is not required for lav or nompC localization in the cilia. Decrease in extracellular sound-evoked potentials. Sounds-evoked potentials, and localization of ktub, iav and nompC is partially restored in a ktub and INPP5E double mutant background.
Translocon-associated protein subunit alpha
Mediator of RNA polymerase II transcription subunit 29
Loss of function; when associated with C-59.
Loss of function; when associated with R-68.
Tyrosine-protein kinase transmembrane receptor Ror
Does not affect phosphorylation by Hipk.
Complete loss of function. Complete loss of self- and ph-p binding activity.
Complete loss of function. Partial loss of self-binding activity. Complete loss of ph-p binding activity.
Complete loss of function. Significant loss of self-binding activity. Moderate loss of ph-p binding activity.
Complete loss of function. Significant loss of self-binding activity. Partial loss of ph-p binding activity.
Loss of self- and ph-p binding activity.
No effect on function. Shows self- and ph-p binding activity comparable to wild-type; when associated with G-816 and R-860.
No effect on function. Shows self- and ph-p binding activity comparable to wild-type; when associated with G-816 and V-846.
No effect on function. Shows self- and ph-p binding activity comparable to wild-type; when associated with V-846 and R-860.
Partial loss of self- and ph-p binding activity.
Several-fold reduction of self-binding activity. Partial loss of ph-p binding activity.
Probable G-protein coupled receptor Mth-like 1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase S
Probable ATP-dependent RNA helicase spindle-E
In stn-TS2; induce behavioral defects. Homozygous adults are viable but exhibit sluggish and uncoordinated behavior.
Dihydroorotate dehydrogenase (quinone), mitochondrial
7SK snRNA methylphosphate capping enzyme bin3
ATP synthase subunit gamma, mitochondrial
Increases numbers of granules containing Nup358/RanBP2 and annulate lamellae containing nuclear pore complex components in egg and nurse cells.
Reduces numbers of granules containing Nup358/RanBP2 and annulate lamellae containing nuclear pore complex components in egg and nurse cells.
Histone-lysine N-methyltransferase eggless
In svr-1; Adult wings are pointed and have shortened veins. Displays decreased cold sensitivity and fails to suppress courtship with previously mated females indicating deficits in long-term memory.
In svr-poi; Adult wings are smaller, pointed and have shortened veins. Displays decreased cold sensitivity and fails to suppress courtship with previously mated females indicating deficits in long-term memory.
In CEP290-1; in olfactory and auditory neurons, transition zones (TZ) fail to form leading to the disassociation of the basal bodies from plasma membrane at later stages cliliogenesis, abnormal elongation of the axoneme and consequently complete loss of cilia. As a consequence, adults are uncoordinated and have severe defects in touch and hearing. In testes, flagellar axonemes are almost completely lost and sperm cyst elongation is severely defective. As a consequence, mature sperms do not develop and so males are completely infertile.
In CEP290-C; no effect on cilium basal body localization.
In CEP290-M; abolishes cilium basal body localization; when associated with 1385-G--E-1978.
In CEP290-N+M; no effect on cilium basal body localization. In CEP290-M; abolishes cilium basal body localization; when associated with 1-M--E-650.
In CEP290-N; no effect on cilium basal body localization however expression in more restricted within the transition zone of auditory cilia. When overexpressed in CEP290-1 mutants, rescues defects in ciliogenesis, basal body docking, transition zone (TZ) assembly, and recruitment of DZP1 and Mks1 to the TZ. It does not rescue uncoordination.
In olfactory and auditory neurons, transition zones (TZ) fail to form, ciliary axonemes are lost and DZIP1 expression is significantly reduced resulting in uncoordination and severe defects in touch and hearing. No effect on connection between the basal bodies and plasma membrane. Mild defects in spermatid development and male fertility. In spermatocyte cilia there is no significant reduction in DZIP1 expression.
Results in motor defects including crossed legs and inability to stand or hold wings erect. In sensory neurons, results in failure to form a transition zone. In cilia, shows severe proprioception defects including defective mechanoreceptor current (MRC) but normal transepithelial potential (TEP). In germ cells, results in defective transition zone assembly and ciliary cap structure; the defects include increased distance between microtubules (MT) and between MT and membrane and it is associated with longer cilium basal body. This leads to ultrastructural axoneme defects without compromising the attachment of spermatocyte centrioles to the membrane.
DDB1- and CUL4-associated factor 12 homolog
Post-GPI attachment to proteins factor 3
Impaired conversion of the pre-RISC complex, containing duplex siRNA, to the holo-RISC complex, containing single-stranded guide siRNA.
Tetratricopeptide repeat protein 14 homolog
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
Translocon-associated protein subunit delta
Abolishes binding to Drice and fails to inhibit cell death. No effect on binding to Dredd.
Abolishes binding to Drice. Loss of immunity to Gram-negative bacteria; when associated with A-163.
Death-associated inhibitor of apoptosis 2
Fails to bind to Dredd and promote its polyubiquitylation.
Loss of caspase-mediated cleavage, failure to protect against Drice-mediated cell death and loss of binding to Drice.
No effect on binding to Drice. Loss of immunity to Gram-negative bacteria; when associated with A-263.
In both embryo and larva, results in irregularly shaped salivary glands with bulges of variable sizes, leading to greater distances between neighboring nuclei.
DNA-directed RNA polymerase I subunit RPA2
Dynein regulatory complex protein 1 homolog
Receptor-mediated endocytosis protein 6 homolog
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Retains interaction with bcn92 and IscU.
Probable G-protein coupled receptor Mth-like 11
Nuclear protein localization protein 4 homolog
Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-172; A-202; A-264; A-270; A-325 and A-349.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-85; A-172; A-202; A-264; A-270 and A-325.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-85; A-172; A-202; A-264; A-270 and A-349.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-85; A-172; A-202; A-264; A-325 and A-349.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-85; A-172; A-202; A-270; A-325 and A-349.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-85; A-172; A-264; A-270; A-325 and A-349.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-53; A-85; A-202; A-264; A-270; A-325 and A-349.
Abolishes phosphorylation but does not affect interaction with IKKepsilon; when associated with A-85; A-172; A-202; A-264; A-270; A-325 and A-349.
In drm2; foregut proventriculus morphologically and functionally defective.
In drm4; foregut proventriculus morphologically and functionally defective.
In drm5; foregut proventriculus morphologically and functionally defective.
In drm6; foregut proventriculus and hindgut morphologically and functionally defective. Abolishes lin binding. Abolishes lin-inhibiting activity.
Reduces lin binding. No effect on lin-inhibiting activity.
Hepatocyte growth factor-regulated tyrosine kinase substrate
No effect on RNA-binding; when associated with D-658; I-724 and R-665.
No effect on RNA-binding; when associated with D-658; I-724 and R-749.
No effect on RNA-binding; when associated with D-658; R-665 and R-749.
No effect on RNA-binding; when associated with L-632.
No effect on RNA-binding; when associated with L-634.
No effect on RNA-binding; when associated with R-665; I-724 and R-749.
Reduced RNA-binding. Complete loss; when associated with A-606.
Reduced RNA-binding. Complete loss; when associated with R-609.
Glutaredoxin domain-containing cysteine-rich protein CG12206
In isoform A, isoform B, isoform C and isoform H.
In isoform A, isoform C, isoform E and isoform G.
In isoform C, isoform F, isoform G and isoform H.
Loss of myristoylation. Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane.
Loss of phosphorylation by PKC. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-135 and A-137.
Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane; when associated with D-132 and D-135.
Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane; when associated with D-132 and D-137.
Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane; when associated with D-135 and D-137.
Partial loss of phosphorylation by PKC; when associated with A-137. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-132 and A-137.
Partial loss of phosphorylation by PKC; when associated with A-13A. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-132 and A-135.
Loss of binding to Rae1 and unable to rescue synaptic terminal overgrowth in mutants.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with 1012-E--E-1014.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with 671-T--R-1011 DEL.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with S-5038.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with S-5041.
Probable G-protein coupled receptor Mth-like 10
Disrupts Ca(2+) inflow through the channel. Calmodulin has little effect on Ca(2+) flow.
Does not abolish Ca(2+) inflow through the channel. Calmodulin has no effect on initial rates.
Transient-receptor-potential-like protein
Gram-negative bacteria-binding protein 3
In strain: Netherlands line N02 and Netherlands line N30.
In strain: Netherlands line N02, Netherlands line N07, Netherlands line N17 and Netherlands line N30.
Putative phospholipase B-like lamina ancestor
Putative sodium-dependent multivitamin transporter
Cilia- and flagella-associated protein 20
Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate Syb. Impaired ability to promote transcytosis of wg.
In strain: Kronenbourg, Madibou4, Primus20, Primus25, ZH34 and ZH83.
Putative mitogen-activated protein kinase kinase kinase 7-like
UV radiation resistance-associated gene protein
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
In BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_5A, BPL_5D, BPL_5F, BPL_6D, BPL_6E, BPL_7F, BPL_8A, BPL_8C, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B, BPL_13A, BPL_13F, Florida1Slow and Paris.
In strain: AfricaFast, AfricaSlow, BPL_10A, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_12F, BPL_13A, BPL_13B, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1F, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2F, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7A, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_7H, BPL_8A, BPL_8B, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_8H, BPL_9A, BPL_9B, BPL_9C, BPL_9D, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, FrenchFast, FrenchSlow, JapanFast, JapanSlow, Paris and WashingtonFast.
In strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, FloridaFast, JapanSlow, Oregon-R, Paris and WashingtonFast.
In strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, Paris and WashingtonFast.
In strain: AfricaFast, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, FloridaFast, Florida1Slow, Paris and WashingtonFast.
In strain: AfricaSlow, AfricaFast, FloridaFast, Florida1Slow, Florida2Slow, FrenchSlow, JapanSlow, Paris and WashingtonFast.
In strain: BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7H, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_9A, BPL_9C, BPL_9F, BPL_9H, FrenchSlow and Paris.
In strain: BPL_1A, BPL_1G, BPL_2A, BPL_2G, BPL_2H, BPL_3C, BPL_4A, BPL_4C, BPL_4G, BPL_5H, BPL_6H, BPL_7C, BPL_10E, BPL_11C, BPL_11H, BPL_12A and WashingtonFast.
In strain: BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B and BPL_13A.
In strain: BPL_1H, BPL_3H, BPL_4B, BPL_5E, BPL_7B, BPL_7H, BPL_8G, BPL_10H and BPL_13C.
In strain: BPL_6H, BPL_7C, BPL_11F and BPL_12A.
In strain: BPL_7A, BPL_9D, BPL_10A and BPL_11E.
Sodium-dependent nutrient amino acid transporter 1
Histone-lysine N-methyltransferase trithorax
In mitoguardian; progressive neurodegeneration in the eye caused by mitochondrial defects. Abolishes localization to the mitochondrion.
In DMAD(Del-CXXC); flies are viable and fertile.
In DMAD-CD(mut); abolishes ability to demethylate m6A DNA.
Ribosome-releasing factor 2, mitochondrial
cAMP-dependent protein kinase catalytic subunit 2
In dsf1; males and females are sterile due to abnormal courtship behaviors and defects in their sex-specific nervous system. Females display active resistance and rejection behaviors during courtship and copulation. Synapses are also absent on the circumferential muscles of the uterus which likely results in the observed egg-laying defect in which the mature eggs reach the uterus but females are unable to lay them. Males actively court both females and males, and during the final step of courtship display defects in abdominal curling which is required to make genital-genital contact with females. The observed slow abdominal bends during mating is likely due, at least in part, to abnormal innervation of the ventral longitudinal muscles of abdominal segment 5 (A5).
In dsf7, greatly decreased DNA binding of fragment 1-102.
Reduced DNA binding and weakly represses DNA transcription.
Mitochondrial import inner membrane translocase subunit Tim9
Succinate dehydrogenase assembly factor 3, mitochondrial
Non-structural maintenance of chromosomes element 1 homolog
In isoform 9, isoform 11 and isoform 13.
4-hydroxybenzoate polyprenyltransferase, mitochondrial
In eye imaginal disks, hh signaling is impaired resulting in delayed differentiation of photoreceptors in the morphogenetic furrow. In Johnston's organs, results in reduced auditory transduction. Often the filamentous structure of NompA at the apical junction of the neuronal cilium and antennal cuticle collapses into puncta resulting in the detachment of scolopidia from the hinge of the second and third antennal segment.
Calcium release-activated calcium channel protein 1
In a15, loss of female-specific DSX splicing and male fertility.
In a36; loss of female-specific DSX splicing. Loss of male fertility.
In d1; greatly reduced female-specific DSX splicing. Retains male fertility.
In d2; greatly reduced female-specific DSX splicing.
In d3; greatly reduced female-specific DSX splicing. Retains male fertility.
In d4; loss of female-specific DSX splicing. Greatly reduced male fertility.
In d5; loss of female-specific DSX splicing. Loss of male fertility.
In pm1; loss of female-specific DSX splicing. Loss of male fertility.
In pm2; no female-specific DSX splicing. Some low male fertility.
In pm3; greatly reduced female-specific DSX splicing. Retains male fertility and temperature-sensitive phenotype.
In pm4; loss of female-specific DSX splicing. Retains male fertility and temperature-sensitive phenotype.
In ts1; little female-specific DSX splicing. Loss of male fertility and temperature-sensitive phenotype.
In ts2; temperature-sensitive phenotype.
In mus308(3294); flies are unable to repair interstrand cross-links.
In mus308(D5); flies are unable to repair interstrand cross-links.
Increases sensitivity to DNA interstrand damage induced by DNA-cross-linking agents and ionizing radiation. Reduces alternative end-joining repair.
Increases sensitivity to DNA interstrand damage induced by DNA-cross-linking agents. Reduces annealing and extension of single-strand DNA molecules in vitro but does not affect end-joining frequency.
In YP3s1; synthesized in the fat body, but not secreted, probably due to the amino acid mutation in the signal peptide.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Mutant flies show an accumulation of reactive oxygen species, mitochondrial dysfunction and neurodegeneration.
Coenzyme Q-binding protein COQ10, mitochondrial
Lack of oxidation modification; results in increased sensitivity to oxidative stress.
NPC intracellular cholesterol transporter 2 homolog a
Incomplete processing of Acp26Aa and Semp1 in mated females.
Loss of cleavage of Acp26Aa and Acp36DE.
No processing of Acp26Aa in mated females and incomplete processing of Semp1.
Probable G-protein coupled receptor Mth-like 5
Guanine nucleotide-binding protein subunit beta-1
Post-GPI attachment to proteins factor 2-like
Zinc finger CCHC domain-containing protein 8 homolog
Guanine nucleotide-binding protein-like 3 homolog
In strain: Usa7, Z36, Z50, Zim7, Zim10, Zim13, Zim15, Zim16, Zim18, Zim39 Zim41 and Zim42.
Deformed epidermal autoregulatory factor 1
In EA 111; results in temperature-sensitive defects in dorsoventral patterning.
In EA 125.3; results in ventralized embryos.
In EA 12A; results in weakly ventralized embryos with ventral denticle bands that are approximately normal in width and the filzkorper have the normal tubular morphology.
In EA 161.13; results in weakly ventralized embryos with ventral denticle bands that are approximately normal in width and the filzkorper have the normal tubular morphology.
In EA 1; results in completely dorsalized embryos.
In EA 20N; results in extreme lateralized embryonic pattern where the most dorsal pattern elements (e.g. dorsal cuticles) and the most ventral pattern element (mesoderm) are absent.
In EA 5.13; results in extreme lateralized embryonic pattern where the most dorsal pattern elements (e.g. dorsal cuticle) and the most ventral pattern element (mesoderm) are absent.
In EA 5022; probable loss of catalytic activity results in partially defective dorsoventral patterning; in gastrulation, shows an intermediate ventralization with the headfold prominent on the dorsal side and some anteriorward displacement of posterior cells along the dorsal site; in late embryogenesis, shows partial filzkorper and head skeleton, as well as ventral denticles erroneously in dorsal position.
In EA 818; results in temperature-sensitive defects in dorsoventral patterning.
In EA 83I and EA 4102; results in ventralized embryos.
In EA 84B; results in weakly ventralized embryos with ventral denticle bands that are approximately normal in width and the filzkorper have the normal tubular morphology.
In EA 8; results in completely dorsalized embryos.
In EA QGDS; results in lateralised embryos.
Loss of catalytic activity results in defective dorsoventral patterning characterized by a complete dorsalization in which there is no ventral furrow or headfold, cells at the posterior do not migrate, and multiple symmetric folds appear along the anterior-posterior axis of the embryo.
Probable loss of calcium binding which might affect catalytic activity. Results in defective dorsoventral patterning showing a complete dorsalization in which there is no ventral furrow or headfold, cells at the posterior do not migrate, and multiple symmetric folds appear along the anterior-posterior axis of the embryo.
Probable loss of catalytic activity results in partially defective dorsoventral patterning; during gastrulation, shows defective ventralization; in late embryogenesis results in moderately dorsalized embryos presenting defective lateral filzkorper, head skeleton and ventral denticles.
Putative mitogen-activated protein kinase 14C
Protein downstream neighbor of son homolog
Mediator of RNA polymerase II transcription subunit 16
MORN repeat-containing protein 4 homolog
Heterogeneous nuclear ribonucleoprotein A1
Protein-lysine N-methyltransferase CG9154
NF-kappa-B inhibitor-interacting Ras-like protein
Markedly reduced interaction with shark. In contrast to the wild-type, does not rescue the ability of macrophages to migrate to a wound when expressed in drpr mutants. Protein still undergoes tyrosine phosphorylation and rescues the defective phagocytosis caused by a loss of endogenous drpr.
Protein still undergoes tyrosine phosphorylation but fails to rescue the defective phagocytosis caused by a loss of endogenous drpr.
Glycine-rich cell wall structural protein
28S ribosomal protein S10, mitochondrial
Accelerates formation and decay of the FAD radical.
Slows down the decay of the FAD radical.
Does not affect maturation of ninaE or Rh3. Does not cause accumulation of membranes at the base of the rhabdomeres or retinal degeneration.
Impairs maturation of ninaE and Rh3. Causes accumulation of membranes at the base of the rhabdomeres and retinal degeneration. Abolishes interaction with Rich. Alters direction of bristle growth and produces aberrations in the circumferential ridges.
Produces short bristles but does not alter the direction of their growth.
Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial
Viable, male-fertile, female-sterile. Female embryos lack mitotic progression with terminal arrest at the first cleavage division.
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Calcium uniporter protein, mitochondrial
Disrupts DXXE motif. Fails to rescue phenotype of genetic knockout.
In mushroom body neurons impairs mitochondrial calcium entry and decreases intermediate-term memory after conditioning; when associated with Q-260.
In mushroom body neurons impairs mitochondrial calcium entry and decreases intermediate-term memory after conditioning; when associated with Q-263.
Long-chain-fatty-acid--CoA ligase heimdall
Probable 28S ribosomal protein S26, mitochondrial
Fat-like cadherin-related tumor suppressor homolog
Heterogeneous nuclear ribonucleoprotein 87F
Loss of catalytic activity. Reduced nuclear size in larval salivary glands.
Serine/threonine-protein kinase haspin homolog
Transcription termination factor 3, mitochondrial
In strain: ZIM5C, ZIM10C, ZIM16C, ZIM18C, ZIM28C, ZIM30C, ZIM34C and ZIM53C.
Armadillo repeat-containing protein gudu
Probable 39S ribosomal protein L49, mitochondrial
Male sterility. Spermatocytes display various defects during early meiotic stages, post-meiotic stages and late spermatogenesis. Defects in early meiotic stages result in karyokinesis and cytokinesis abnormailities and a failure to complete meiosis I. Differentiation arrest prior to spermatid individualization results in seminal vesicles lacking mature sperm.
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
In vret(39); egg chambers are defective with abnormal nurse cell numbers and improper oocyte positioning. Follicle cells often fail to encapsulate egg chambers, and occasionally form disorganized multicellular layers.
In vret(46); egg chambers are defective with abnormal nurse cell numbers and improper oocyte positioning. Follicle cells often fail to encapsulate egg chambers, and occasionally form disorganized multicellular layers.
In vret(48-15); ventralized eggs with no defects in somatic gonadal cell patterning, germ cell differentiation or oocyte specification.
In vret(48-60); the germarium is filled with germ cells that maintain a round spectrosome, suggesting failure of germline stem cells to differentiate.
In vret(49); ventralized eggs with no defects in somatic gonadal cell patterning, germ cell differentiation or oocyte specification.
In allele ATP-alpha-dts1; homozygous lethal and temperature dependent bang sensitive paralysis, shortened life span and neurodegeneration when heterozygous.
In allele ATP-alpha-dts2; homozygous lethal and temperature dependent bang sensitive paralysis, shortened life span and neurodegeneration when heterozygous.
In isoform 2, isoform 3, isoform 6 and isoform 7.
Sodium/potassium-transporting ATPase subunit alpha
Ubiquitin-fold modifier-conjugating enzyme 1
Gram-negative bacteria-binding protein 1
39S ribosomal protein L10, mitochondrial
Thioredoxin-related transmembrane protein 2 homolog
LMBR1 domain-containing protein 2 homolog
In Pum680; abolishes interaction with brat and translational repression activity but not RNA-binding activity.
Guanine nucleotide-binding protein subunit gamma-1
Low molecular weight phosphotyrosine protein phosphatase 2
In allele Ddc-R6, allele Ddc-R9, allele Ddc-R16, allele Ddc-R20, allele Ddc-R25 and allele Ddc-R30.
Probably constitutively active (GTP-locked form). Does not affect interaction with CG11448.
Probably constitutively inactive (GDP-locked form). Abolishes interaction with CG11448.
Single-pass membrane and coiled-coil domain-containing protein 4 homolog
In strain: MEL02, ZBMEL84, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398.
In strain: ZBMEL84, ZBMEL384 and ZBMEL398.
Ubiquitin-like modifier-activating enzyme 5
In strain: Riv04, Riv14, Riv16, Riv17, Riv18, Riv35, Riv59 and Wisconsin.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-19 and R-109.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-19 and R-52.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-52 and R-109.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-19, R-52 and R-109.
Significant increase in apoptosis when overexpressed in muscle cells, resulting in severe wing posture abnormalities and impaired climbing ability.
Voltage-dependent anion-selective channel
Translationally-controlled tumor protein homolog
In eys(734); fails to form an interrhabdomeral space.
THUMP domain-containing protein 1 homolog
Signal recognition particle subunit SRP68
Abolishes histone acetyltransferase activity.
In strain: Africa-0, Africa-3, Africa-4, Congo 194 and Mof.591A.s.
In strain: Congo 159, Congo 194 and Congo 216.
In strain: Congo 8, Congo 13, Congo 194 and Mof.820A.s.
Nearly abolishes histone acetyltransferase activity.
Strongly reduces histone acetyltransferase activity. Males fail to metamorphose and hatch.
Putative polypeptide N-acetylgalactosaminyltransferase 13
39S ribosomal protein L33, mitochondrial
Adults display adherent transition zone (TZ) assembly and cilia are almost completely lost in auditory neurons. Consequently, adults display defects associated with ciliary dysfunction and disorganization, such as uncoordination, inability to stand, and severely deficient in touch and hearing. In spermatocytes, ciliary axonemes extend aberrantly and the basal body and plasma membrane separate at later stages of spermatogenesis.
Viable but displays adherent transition zone (TZ) assembly in sensory neurons and spermatocytes. Consequently, adults display defects associated with ciliary dysfunction and disorganization, such as severe uncoordination and axonemal defects and dispersed nuclei in the testes. Cilia are essentially absent in antennal chordotonal organs, transition zones are disorganized and microtubules fail to elongate.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Does not affect dimerization or binding to Rok.
Loss of dimerization and binding to Rok.
Guanine nucleotide-binding protein subunit alpha homolog
In J55; embryonic lethality with excessively elongated tracheal tubes.
In K104; embryonic lethality with excessively elongated tracheal tubes.
In K93; embryonic lethality with excessively elongated tracheal tubes.
In L224; embryonic lethality with excessively elongated tracheal tubes.
cGMP-dependent protein kinase, isozyme 1
cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B
cGMP-dependent protein kinase, isozyme 2 forms cD5/T2
Probable G-protein coupled receptor CG31760
Eukaryotic translation initiation factor 3 subunit M
O-(3'-phospho-DNA)-tyrosine intermediate
In strain: NapaValley5, NapaValley12, sonoma_015, sonoma_016, sonoma_023, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094, sonoma_097 and sonoma_119.
In strain: nps_19, nps_21, nps_25, nps_26, nps_27, nps_30, nps_31, nps_33, nps_35, nps_42, nps_43, nps_45, nps_47, sonoma_002, sonoma_003, sonoma_004, sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009, sonoma_014, sonoma_016, sonoma_017, sonoma_022, sonoma_024, sonoma_032, sonoma_033, sonoma_036, sonoma_038, sonoma_045, sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_059, sonoma_061, sonoma_064, sonoma_081, sonoma_086, sonoma_087, sonoma_094, sonoma_095, sonoma_097, sonoma_106, sonoma_107 and sonoma_119.
In strain: nps_6, nps_18, nps_34, sonoma_048 and sonoma_050.
In strain: sonoma_006, sonoma_022 and sonoma_040.
In strain: sonoma_008, sonoma_015, sonoma_016, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094 and sonoma_097.
In strain: sonoma_009, sonoma_051, sonoma_053 and sonoma_054.
In strain: sonoma_010, sonoma_013, sonoma_019 and sonoma_117.
Elongation of very long chain fatty acids protein F
Putative inorganic phosphate cotransporter
Probable G-protein coupled receptor Mth-like 12
Abolishes L,D-carboxypeptidase activity on DAP-type PGN.
Abolishes PGN-binding and activation of Toll pathway.
Abolishes PGN-binding and activation of Toll pathway. Abolishes L,D-carboxypeptidase activity on DAP-type PGN.
Does not affect activation of Toll pathway.
In seml; induces susceptibility to Gram-positive bacterial infection.
Increases PGN-binding and activation of Toll pathway.
Strongly reduces PGN-binding and activation of Toll pathway.
Guanine nucleotide-binding protein subunit gamma-e
In strain: NVIII-1, NVIII-2, NVIII-5, NVIII-9, NVIII-18, NVIII-22, NVIII-24, NVIII-41, NVIII-42, NVIII-46, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
In strain: NVIII-5, NVIII-9, NVIII-46 and NVIII-41.
Serine/threonine-protein phosphatase alpha-3 isoform
Eukaryotic translation initiation factor 3 subunit B
Tetratricopeptide repeat protein 30 homolog
28S ribosomal protein S24, mitochondrial
Glycoprotein 3-alpha-L-fucosyltransferase A
Loss of GTPase activity. Loss of endoplasmic reticulum membrane fusion. Does not oligomerize.
Probable G-protein coupled receptor Mth-like 2
Coiled-coil domain-containing protein CG32809
Decrease in response to SP. Response to MIP is less affected.
Conserved oligomeric Golgi complex subunit 1
Constitutively active kinase; reduces microtubule sliding to similar levels of wild-type (in vitro).
Loss of catalytic activity; increases microtubule sliding (in vitro).
Serine/threonine-protein kinase tricornered
Glucose dehydrogenase [FAD, quinone] short protein
Nonsense-mediated mRNA decay factor SMG8
KRR1 small subunit processome component homolog
Phosphatidate cytidylyltransferase, photoreceptor-specific
Detected in spermatocyte cysts during meiosis but expression is diffuse. No localization to the fusome or actin cones.
In strain: MEL11, MEL12, ZBMEL82, ZBMEL131, ZBMEL186, ZBMEL191 and ZBMEL229.
Transmembrane emp24 domain-containing protein bai
Ragulator complex protein LAMTOR4 homolog
Polypeptide N-acetylgalactosaminyltransferase 2
In swmF15; recessive lethal and induces reduced fucosylation levels.
Chymotrypsin-like elastase family member 2A
Eukaryotic translation initiation factor 2A
In allele Adh-F, allele Adh-F-CHD, allele Adh-71K, allele Adh-JA-F and in strain: Berkeley.
Trafficking kinesin-binding protein milt
Probable methyltransferase-like protein 15 homolog
Impaired cell growth, survival of postmitotic ommatidial cells and differentiation into R8 photoreceptors. Normal eye morphology; when associated with V-12.
Mild rough eye phenotype; when associated with V-12.
Rough eyes characterized by the presence of additional R7 photoreceptor cells. Normal survival of postmitotic ommatidial cells but differentiation into photoreceptor cells is limited to R8 cells. Less severe Rough eye phenotype; when associated with E-38. Normal eyes; when associated with C-40.
Probable cytosolic iron-sulfur protein assembly protein Ciao1
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
When in a heterodimer with Chrac-16, reduces Acf binding but does not affect DNA binding or Acf nucleosome sliding activity.
When in a heterodimer with Chrac-16, reduces DNA binding and is less able to stimulate Acf nucleosome sliding activity.
In strain: MEL01, MEL02, MEL12, MEL13, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL84, ZBMEL95, ZBMEL131, ZBMEL157, ZBMEL191, ZBMEL377 and ZBMEL398.
In strain: MEL11, ZBMEL145, ZBMEL131, ZBMEL229 and ZBMEL384.
LEM domain-containing protein Bocksbeutel
Partially rescues sterility when transfected in a homozygous mutant fly.
Zinc finger MYND domain-containing protein 10 homolog
Putative oligosaccharyltransferase complex subunit CG9662
26S proteasome non-ATPase regulatory subunit 6
Signal recognition particle 9 kDa protein
Mitochondrial import inner membrane translocase subunit TIM50-A
Mitogen-activated protein kinase kinase kinase 7
Putative peptidyl-prolyl cis-trans isomerase dodo
In PB70; weak allele that only affects female fertility without affecting male fertility.
Inactive peptidyl-prolyl cis-trans isomerase shutdown
In allele RU-35; bicaudal phenotype; lowers RNA-binding.
Breast carcinoma-amplified sequence 3 homolog
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
In PJ42 mutant; loss of exu function in female.
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 1
Gram-negative bacteria-binding protein 2
In strain: Netherlands line N07 and Netherlands line N14.
Probable isoaspartyl peptidase/L-asparaginase CG7860 alpha chain
Probable isoaspartyl peptidase/L-asparaginase CG7860 beta chain
Breast cancer type 2 susceptibility protein homolog
Increased interaction with ck and large percentage of detached scolopidia in Johnston's organs.
Large percentage of detached scolopidia in Johnston's organs but no effect on interaction with ck.
Small percentage of detached scolopidia in Johnston's organs but no effect on interaction with ck.
Increases apoptosis in the eye imaginal disk thereby leading to a rough eye phenotype.
7-methylguanosine phosphate-specific 5'-nucleotidase
Considerable increase (12-fold) in KM for m(7)GMP and decreases KM 3-fold for CMP. Decreases KM 6-fold for m(7)GMP and increases KM 2-fold for CMP; when associated with His-75. Decreases KM 1.5-fold for m(7)GMP and increases KM 1.5-fold for CMP; when associated with Asn-76. Increases KM 7-fold for CMP; when associated with 75-His--Asn-76.
Decreases KM 6-fold for m(7)GMP. Decreases KM 1.5-fold for m(7)GMP and increases KM 1.5-fold for CMP; when associated with Trp-121.
Increases KM 3-fold for m(7)GMP and increases KM 10-fold for CMP. Decreases KM 6-fold for m(7)GMP and increases KM 2-fold for CMP; when associated with Trp-121.
Increases KM 7-fold for CMP; when associated with Trp-121.
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Vacuolar protein sorting-associated protein 28 homolog
Probable G-protein coupled receptor Mth-like 4
Transcription termination factor, mitochondrial
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
CCR4-NOT transcription complex subunit 10
Biogenesis of lysosome-related organelles complex 1 subunit 2
cAMP-specific 3',5'-cyclic phosphodiesterase
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I
cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G
Histone-lysine N-methyltransferase SETD1
In G5; predominantly lethal at the pupal stage with low levels of late L3 larval lethality.
Probable ATP-dependent RNA helicase CG8611
3,4-dihydroxyphenylacetaldehyde synthase
G patch domain and ankyrin repeat-containing protein 1 homolog
Seamless tube overgrowth at terminal cell tip branches.
Supporter of activation of yellow protein
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Schwannomin-interacting protein 1 homolog
In strain: MB01a, MB13a, MB15b and MB46b.
In strain: MB34a, MB36a, MB45b, MB46b, MB47a and MB58b.
SET domain-containing protein SmydA-8, isoform A
SET domain-containing protein SmydA-8, isoform B
Mitochondrial tRNA-specific 2-thiouridylase 1
Probable histone-lysine N-methyltransferase CG1716
Has no effect on nervous system function but reduces binding to Pka-C3.
In allele sws-4; age-dependent neurodegeneration.
In allele sws-5; age-dependent neurodegeneration.
Decrease in apparent molecular weight of 16 kDa subunit.
Decrease in apparent molecular weight of 55 kDa subunit. Decrease in apparent molecular weight of 55 kDa subunit equivalent to the sum of decreases observed with S-174; D-133 and D-331; when associated with D-331 and D-531.
Decrease in apparent molecular weight of the 55 kDa subunit. Decrease in apparent molecular weight of 55 kDa subunit equivalent to the sum of individual decreases observed with S-174; D-331 and D-531; when associated with S-174 and D-331.
Decrease in apparent molecular weight of the 55 kDa subunit. Decrease in apparent molecular weight of 55 kDa subunit equivalent to the sum of individual decreases observed with S-174; D-331 and D-531; when associated with S-174 and D-531.
No change in apparent molecular weight of the 55 kDa subunit.
Polypeptide N-acetylgalactosaminyltransferase 8
Greatly reduces complex helicase activity.
Ribonucleoside-diphosphate reductase subunit M2
Decreased aminoacylation, increased misacylation of non-cognate Tyr, increased amino acid misincorporation, ommatidia defects, neurodegeneration, impaired locomotive performance, reduced lifespan, smaller organ size due to reduced cell proliferation and increased ER stress. Similar but stronger phenotypes except that smaller organ size is due primarily to apoptosis; when associated with 'W-158' in beta subunit.
Phenylalanine--tRNA ligase alpha subunit
Phosphatidylinositol-binding clathrin assembly protein LAP
UDP-xylose and UDP-N-acetylglucosamine transporter
Increases the amount of synaptic boutons and microtubule loops when expressed presynaptically.
ATP synthase-coupling factor 6, mitochondrial
In allele Z1091; wing expansion defects, failure to sclerotize cuticle.
In allele Z1140; wing expansion defects.
In allele Z5569; wing expansion defects, failure to sclerotize cuticle.
Abolishes phosphorylation and interaction with 14-3-3-zeta; when associated with A-54.
Abolishes phosphorylation and interaction with 14-3-3-zeta; when associated with A-79.
Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial
Results in a loss of odor-evoked response to acetic acid and a gain of response to butyric acid and 2-oxopentanoic acid; when associated with K-536 and L-538.
Results in a loss of odor-evoked response to acetic acid and a gain of response to butyric acid and 2-oxopentanoic acid; when associated with T-289 and K-536.
Results in a loss of odor-evoked response to acetic acid and a gain of response to butyric acid and 2-oxopentanoic acid; when associated with T-289 and L-538.
Strong defects in abdomen and oogenesis.
Strong defects in abdomen and oogenesis. Reduces binding of zinc. Complete loss of zinc-binding and loss of function; when associated with Y-319.
Strong defects in abdomen and oogenesis. Reduces binding of zinc. Complete loss of zinc-binding and loss of function; when associated with Y-354.
Strong defects in oogenesis. Weak defects in abdomen.
Oxygen-dependent coproporphyrinogen-III oxidase
Thioredoxin domain-containing protein 5 homolog
In bnch(N); leads to storage in yolk spheres during oogenesis and results in widespread accumulation of enlarged lysosomal and late endosomal inclusions.
Gamma-aminobutyric acid receptor subunit beta-like
In strain: DI7, Loua, Monty5, Tahiti and ZW141.
Decreases animal survival. No effect on head morphogenesis.
26S proteasome non-ATPase regulatory subunit 4
DNA-directed RNA polymerase II subunit Rpb4
Probable sodium/potassium/calcium exchanger CG1090
In isoform I, isoform H, isoform K and isoform L.
Mediator of RNA polymerase II transcription subunit 13
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093 and A-1102.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Significant loss of DNA underreplication in larval salivary glands; when associated with 1076-A-A-1077.
Significant loss of DNA underreplication in larval salivary glands; when associated with 1101-A--A-1103.
Vacuolar ATPase assembly integral membrane protein VMA21 homolog
Nuclear envelope phosphatase-regulatory subunit 1 homolog
Peroxisomal multifunctional enzyme type 2
Signal recognition particle 19 kDa protein
In ash1-10; induces lethality between prepupal and late pupal stages.
In ash1-21; induces lethality between prepupal and late pupal stages.
Serine/threonine-protein kinase minibrain
GTPase-GDP dissociation stimulator vimar
Very long-chain-fatty-acid--CoA ligase bubblegum
Significant decrease in TORC1 activity in adult ovaries indicated by reduced phosphorylation of S6K/p70S6K and the accumulation of autolysosomes. Female germline clones are smaller compared to wild-type cells. In contrast, somatic tissues do not display a significant decrease in TORC1 activity and there is only a negligible decrease in cell size. RNAi-mediated knockdown of Nprl1 or Nprl3 rescues the ovarian defects in mutants, but not the accumulation of lysosomes.
6-phosphogluconate dehydrogenase, decarboxylating
Nudix hydrolase domain-containing protein
Probable ATP-dependent RNA helicase Dbp73D
Loss of phosphoribosylglycinamide formyltransferase enzymatic activity.
Trifunctional purine biosynthetic protein adenosine-3
Serine/threonine-protein phosphatase Pgam5, mitochondrial
Probable U2 small nuclear ribonucleoprotein A'
Reduced localization to the lamellipodia, likely resulting from decreased interaction with Cortactin.
DNA-directed RNA polymerase II subunit RPB9
Rhodanese domain-containing protein CG4456
Reduces enzyme activity towards dA, dG, dT and dC about 5-fold.
Reduces enzyme activity towards dT and dC about 500-fold. Reduces enzyme activity towards dG about 3900-fold. Reduces enzyme activity towards dA about 900-fold.
H/ACA ribonucleoprotein complex subunit 3
Vacuolar protein sorting-associated protein 51 homolog
Eukaryotic translation initiation factor 3 subunit F-1
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Poly(U)-binding-splicing factor half pint
Dominant-negative mutant that inhibits Notch signaling.
Loss of function. Abolishes homomultimerization; when associated with A-571.
Loss of function. Abolishes homomultimerization; when associated with A-574.
Translocon-associated protein subunit beta
Probable phosphorylase b kinase regulatory subunit alpha
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
60 kDa heat shock protein homolog 1, mitochondrial
Abolishes interaction with Tnks but does not affect interaction with PSMD5 and PSMD9; when associated with A-49.
Abolishes interaction with Tnks but does not affect interaction with PSMD5 and PSMD9; when associated with A-54.
Abolishes interaction with Tnks, PSMD5 and PSMD9.
Abolishes interaction with Tnks, PSMD5 and PSMD9. Reduces 26S proteasome activation.
Fails to rescue null mutant phenotype; when associated with E-103.
Fails to rescue null mutant phenotype; when associated with E-96.
Alanine--glyoxylate aminotransferase 2-like
39S ribosomal protein L19, mitochondrial
In ttv205; induces defects in wing patterning due to impaired movement of morphogens.
In allele ssm; maternal effect embryonic lethal mutation which impairs maternal histone deposition in the male pronucleus.
In swi-t467; lethal during puparium formation.
Putative 1-phosphatidylinositol 3-phosphate 5-kinase
In SAK-ND; impairs interaction with SCF-slmb ubiquitin ligase complex and subsequent ubiquitination; when associated with A-292.
In SAK-ND; impairs interaction with SCF-slmb ubiquitin ligase complex and subsequent ubiquitination; when associated with A-297.
Dolichyl-phosphate beta-glucosyltransferase
Fails to rescue glycosylation and growth phenotypes in yeast.
Formation of tetramers, dimers and monomers.
Mainly tetrameric with formation of some monomers. Mainly dimeric; when associated with D-726.
Mainly tetrameric. Mainly dimeric; when associated with R-775.
Spindle defects and greatly reduced phosphorylation by Wee1 in vitro; when associated with F-152 and F-207.
Spindle defects and greatly reduced phosphorylation by Wee1 in vitro; when associated with F-23 and F-152.
Spindle defects and greatly reduced phosphorylation by Wee1 in vitro; when associated with F-23 and F-207.
Fibronectin type-III domain-containing protein
Abolishes homodimerization and subcellular targeting of pip.
Affects subcellular targeting of pip but not homodimerization.
Affects subcellular targeting of pip; when associated with Q-212.
Affects subcellular targeting of pip; when associated with S-219.
Does not affect homodimerization. Abolishes homodimerization and subcellular targeting of pip; when associated with N-31.
Does not affect subcellular targeting of pip.
Impairs homodimerization. Abolishes homodimerization and subcellular targeting of pip; when associated with S-41.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-132 in APG5)
tRNA N(3)-methylcytidine methyltransferase Mettl2
Structure-specific endonuclease subunit SLX4
Acetylcholine receptor subunit beta-like 2
No effect on binding to wash and no effect on tail hemocyte developmental migration from the tail.
Reduces binding to wash. Reduces the number of hemocytes migrating anteriorly from the tail during embryogenesis.
Glycine-rich cell wall structural protein-like
ER membrane protein complex subunit 8/9 homolog
Severe retardation of TFAM degradation following mtDNA depletion.
Loss of peptidoglycan-induced oligomerization.
Loss of peptidoglycan-induced oligomerization. Strongly reduced affinity for peptidoglycan.
Strongly reduced affinity for peptidoglycan.
5-glutamyl coenzyme A thioester intermediate
Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
Mediator of RNA polymerase II transcription subunit 31
Alcohol dehydrogenase-related 31 kDa protein
In allele eIF4AIII-19; homozygous oocytes are non-viable.
Putative ATP-dependent RNA helicase SoYb
Mediator of RNA polymerase II transcription subunit 25
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Transient receptor potential cation channel subfamily A member 1
Probable 26S proteasome non-ATPase regulatory subunit 3
39S ribosomal protein L51, mitochondrial
In allele mago-93D; expression of rolled/MAPK in developing eye and wing tissue is severely reduced, and photoreceptor differentiation is impaired.
Asparagine synthetase domain-containing protein CG17486
V-type proton ATPase catalytic subunit A isoform 2
In Msh4-4; abnormalities in sense organ precursor (SOP) cells and their progeny. Chordotonal organs contain fewer neurons and glial cells and migration of the progeny cells derived from the SOPs in embryos are significantly desynchronized among different segments.
Abolishes guanylate cyclase activity but does not affect cell surface location.
In 3L043; complete loss of the posterior crossvein in adult wings.
Cysteine and histidine-rich domain-containing protein morgana
Early larval lethal. Homozygous neurons (generated by mosaic analysis) display decreased elongation/retraction rate of terminal branches, resulting in small dendritic arbors regardless of pupal body size and/or nutritional input. Also in both fed and starved pupae, dendritic segment length is decreased without simplifying the branching pattern.
H/ACA ribonucleoprotein complex non-core subunit NAF1
Strongly reduced interaction with DCP1A, but no effect on P-body targeting; when associated with A-42.
Strongly reduced interaction with DCP1A, but no effect on P-body targeting; when associated with A-44.
Strongly reduced interaction with DCP1A. No effect on P-body targeting.
Histone-lysine N-methyltransferase Suv4-20
Nuclear receptor binding SET domain protein
Transcription initiation factor TFIID subunit 11
Sodium/potassium/calcium exchanger Nckx30C
Impairs microtubule polymerization, decreases microtubule lattice localization.
Impairs microtubule polymerization. Disrupts tubulin binding; when associated with E-21.
Impairs microtubule polymerization. Disrupts tubulin binding; when associated with E-292.
Probable galactose-1-phosphate uridylyltransferase
In isoform 1, isoform C, isoform O and isoform R.
In isoform A, isoform C, isoform G, isoform W, isoform MS11, isoform O and isoform R.
In isoform W, isoform MS16 and isoform R.
In strain: DI7, Draveil, Loua, Monty5, Tahiti, Texas, S30 and ZW141.
In strain: Loua, Monty5, P. bourg, Tahiti, Texas and S30.
DDB1- and CUL4-associated factor 10 homolog
Centrosome-associated zinc finger protein CP190
Guanine nucleotide-binding protein subunit beta-like protein
Required for activity. Inhibits negative regulation of Rho1 but has no effect on the positive regulation of Rac1.
Vacuolar protein-sorting-associated protein 36
Results in a defective gastrulation with excessive ventralization showing very prominent ventral furrow, no anterior displacement of posterior cells and only a small headfold on the dorsal side of the embryo.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1259; D-1302 and D-1338 or with D-1259 and D-1338.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1259; D-1302 and D-1390 or with D-1259 and D-1390.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1259; D-1338 and D-1390.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1302; D-1338 and D-1390 or with D-1338 and D-1390.
Retains binding to Mad1; when associated with A-1259; A-1302 and A-1338.
Retains binding to Mad1; when associated with A-1259; A-1302 and A-1390.
Retains binding to Mad1; when associated with A-1259; A-1338 and A-1390.
Retains binding to Mad1; when associated with A-1302; A-1338 and A-1390.
Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Probable tRNA (uracil-O(2)-)-methyltransferase
Mediator of RNA polymerase II transcription subunit 28
In chinmo-M33; mushroom body neuroblast clones contain increased numbers of late-born alpha/beta type neurons and fewer early-born gamma type neurons.
26S proteasome non-ATPase regulatory subunit 7
Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain hydrolysis; when associated with S-181.
Loss of H2B deubiquitination. Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain hydrolysis; when associated with N-369.
Ubiquitin carboxyl-terminal hydrolase 36
DNA mismatch repair protein spellchecker 1
Coiled-coil domain-containing protein 22 homolog
In strain: Berkeley, JP-1, JP-5, JP-15, JP-35, JP-55, JP-65, JP-84, KN-12, KN-22 and KN-27.
In strain: JP-75, KN-7, KN-15, KN-17, KN-21 and KN-23.
Probable citrate synthase, mitochondrial
Abolishes activity; no effect on interaction with comm.
Protocadherin-like wing polarity protein stan
In strain: NC304, NC322, NC359, NC361 and NC399.
Transport and Golgi organization protein 1
Probable G-protein coupled receptor Mth-like 8
Sodium/potassium-transporting ATPase subunit beta-2
General transcription factor IIH subunit 1
Ubiquinone biosynthesis protein COQ9, mitochondrial
Chromatin-remodeling complex ATPase chain Iswi
In isoform 2a, isoform 2b and isoform 2c.
In strain: Nv2001_f0696, NVIII-46 and NVIII-24.
Eukaryotic translation initiation factor eIF1
Modular serine protease non-catalytic chain
cAMP-dependent protein kinase type II regulatory subunit
Stress-activated map kinase-interacting protein 1
In strain: AF-F, F1-F, F1-1S, JA-F, LW8, MW18 and ZW20.
DNA polymerase interacting tetratricopeptide repeat-containing, protein of 47 kDa
Zinc finger SWIM domain-containing protein 8 homolog
Serine/threonine-protein kinase Genghis Khan
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ATP-dependent RNA helicase DHX15 homolog
In allele mod(mdg4)351; embryonic lethal; when associated with N-33.
In allele mod(mdg4)351; embryonic lethal; when associated with S-92.
Transcription initiation factor TFIID subunit 5
Putative glycogen synthase kinase-3 homolog
Putative ATP synthase subunit f, mitochondrial
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Reduction in levels of cleavage; when associated with Asp-92.
Reduction in levels of cleavage; when associated with Asp-93.
Reduction in levels of cleavage; when associated with Trp-79.
Reduction in levels of cleavage; when associated with Trp-80.
Serine protease HTRA2, mitochondrial, long
Serine protease HTRA2, mitochondrial, short
Abolished nucleotidyltransferase activity.
Ubiquitin carboxyl-terminal hydrolase 32
>D: In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; A-342; E-346; A-347 and D-348.
Cbl-mediated ubiquitination, in response to high levels of Egfr ligand spi, is impaired resulting in reduced interaction with Graf and thus decreased GEEC-mediated endocytosis and degradation. Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1310; F-1342 and 1405-F-F-1406.
Decreased interaction with EGFRAP; when associated with F-1357.
Forms dimers in presence of spitz. Forms weak dimers in the absence of spitz.
In dim-arm; Does not form dimers even in the presence of Spitz; when associated with E-341; A-342; D-344; E-346 and D-348.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with A-342; D-344; E-346; A-347 and D-348.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; A-342; D-344; A-347 and D-348.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; A-342; D-344; E-346 and A-347.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; D-344; E-346; A-347 and D-348.
In tether; No effect on binding to spitz; when associated with A-646 and A-649.
In tether; No effect on binding to spitz; when associated with A-646 and A-658.
In tether; No effect on binding to spitz; when associated with A-649 and A-658.
Increased binding to spitz; when associated with A-101; A-358 and S-369.
Increased binding to spitz; when associated with A-131; A-358 and S-369.
No effect on interaction with EGFRAP. Decreased interaction with EGFRAP; when associated with 1405-F-F-1406. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1271; F-1310.
Reduced dissociation and increased binding to spitz; when associated with A-358. Increased binding to spitz; when associated with A-101; A-131 and A-358.
Reduced dissociation and increased binding to spitz; when associated with S-369. Increased binding to spitz; when associated with A-101; A-131 and S-369.
Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1271; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1271; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1246; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1246; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1095; F-1218; F-1246; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1218; F-1246; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1204; F-1218; F-1246; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1204; F-1218; F-1246; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Actin-related protein 2/3 complex subunit 2
Cyclic AMP response element-binding protein B
Fails to block PKA-dependent activation by isoform E; in isoform G.
In isoform D, isoform F, isoform G and isoform J.
In ago-3; increased cell proliferation and decrease in ability to bind CycE.
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Eukaryotic translation initiation factor 3 subunit G-2
In isoform I, isoform H, isoform L and isoform K.
Adipocyte plasma membrane-associated protein Hemomucin
Retinoid-inducible serine carboxypeptidase
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog
39S ribosomal protein L39, mitochondrial
Ribonucleoside-diphosphate reductase large subunit
N6-adenosine-methyltransferase MT-A70-like protein
Severe lethality; when associated with A-413.
Severe lethality; when associated with A-416.
dolichyl-phosphate-mannose--protein mannosyltransferase
Ornithine aminotransferase, mitochondrial
EGF domain-specific O-linked N-acetylglucosamine transferase
Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Minor reduction of in vitro phosphorylation by CkIIalpha; when associated with A-327 and A-332.
Minor reduction of in vitro phosphorylation by CkIIalpha; when associated with A-327 and A-333.
Minor reduction of in vitro phosphorylation by CkIIalpha; when associated with A-332 and A-333.
Strongly reduced in vitro phosphorylation by CkIIalpha; when associated with A-288 and A-290.
Strongly reduced in vitro phosphorylation by CkIIalpha; when associated with A-288 and A-292.
Strongly reduced in vitro phosphorylation by CkIIalpha; when associated with A-290 and A-292.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial
In csn5-3; disrupts R cell projections. Impairs the interaction with Trc8.
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Loss of interaction with CG7546. Retains ubiquitin-protein ligase activity.
Loss of ubiquitination activity; when associated with A-253.
Loss of ubiquitination activity; when associated with A-256.
Chromatin accessibility complex 16kD protein
When in a heterodimer with Chrac-14, does not affect DNA binding or Acf nucleosome sliding activity.
When in a heterodimer with Chrac-14, enhances DNA binding.
Abolishes interaction with Nedd4 and reduces ubiquitination.
In mcd5; induces loss of microchaetae sensory precursors.
In su42c; deltex-like mutation that induces outstreched wings and variability-fused ocelli.
Processed neurogenic locus Notch protein
In Ala5: Induces apoptosis; when associated with A-121, A-148, A-180 and A-228.
In Ala5: Induces apoptosis; when associated with A-121, A-148, A-180 and A-251.
In Ala5: Induces apoptosis; when associated with A-121, A-148, A-228 and A-251.
In Ala5: Induces apoptosis; when associated with A-121, A-180, A-228 and A-251.
In Ala5: Induces apoptosis; when associated with A-148, A-180, A-228 and A-251.
Glutathione S-transferase C-terminal domain-containing protein homolog
Cleavage and polyadenylation specificity factor 73
Ribosome biogenesis protein BOP1 homolog
Rab3 GTPase-activating protein catalytic subunit
Mediator of RNA polymerase II transcription subunit 19
Phosphoserine; by PHK; in form phosphorylase A
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
In 6; normal eye color. Eyes are brown due to a reduction in red pigment production in a w/white co2 mutant background.
In T50; normal eye color. Eyes are brown due to a reduction in red pigment production in a w/white co2 mutant background.
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Probable cytochrome P450 12c1, mitochondrial
Dorsal-ventral patterning protein tolloid
Fibroblast growth factor receptor homolog 2
In strain: fs(3)Neo61, Wpg1, Wpg10, Wpg16, Wpg2, Wpg3, Zim10, Zim18, Zim32 and Zim35.
In strain: Zim63H-16C, Zim63H-34C and Zim63I-7C.
In Sce33M2; induces extra sex combs due to derepression of Ubx homeotic gene and abolishes ability to ubiquitinate histone H2A.
VWFA and cache domain-containing protein CG16868
Guanine nucleotide-binding protein G(f) subunit alpha
Defective chorion protein, FC106 isoform
Defective chorion protein, FC125 isoform
Defective chorion protein, FC177 isoform
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
In follicle epithelial cells, apical accumulation of the basal membrane protein vkg as apical extracellular aggregates. Crag levels decrease and Crag no longer accumulates at the plasma membrane, instead it has a diffuse cytoplasmic distribution. No direct effect on maintenance of apical-basal polarity in follicle cells.
In follicle epithelial cells, decreases extracellular PtdInsP2 on apical and lateral sides of the plasma membrane resulting in the abnormal apical accumulation of basal membrane proteins such as vkg. As a consequence the follicle cells display multiple layers or gaps in the epithelium.
Probable tRNA N6-adenosine threonylcarbamoyltransferase
Decreased interaction with F-BAR domain. No effect on interaction with Dap160.
Heparan sulfate 2-O-sulfotransferase pipe
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Biogenesis of lysosome-related organelles complex 1 subunit 5
In strain: Usa1, Zim15, Zim18, Zim22, Zim39 and Zim42.
In strain: Usa3, Usa16, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50.
In strain: Usa3, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50.
In strain: Usa8, Usa12, Usa16, Zim18, Zim39 and Zim41.
In strain: Usa8, Usa12, Usa16, Zim7, Zim10, Zim13, Zim15, Zim16, Zim18, Zim22, Zim39, Zim42, Z36 and Z50.
In strain: Zim10, Zim13, Zim16, Zim18, Zim39, Z36 and Z50.
Mitochondrial import inner membrane translocase subunit Tim10
Solute carrier family 35 member B1 homolog
Abolishes methylation and interaction with tud. Does not affect piRNA binding.
Putative catalytic mutant. Enhances meiotic drive.
Kinetochore and Eb1-associated basic protein
No effect on Eb1 binding, and no effect on kinetochore and microtubule localization.
Slight reduction in Eb1 binding. No effect on kinetochore and microtubule localization.
Lipid storage droplets surface-binding protein 1
GDP-fucose protein O-fucosyltransferase 1
Neither inactivation nor afterpotential protein G
Fails to export proteins containing leucine-rich nuclear export signal (NES) from the nucleus.
Results in lethality at larval stage. This is reversed by removal of one chromosome copy of Nup214. Fails to export proteins containing leucine-rich nuclear export signal (NES) from the nucleus.
SH3 domain-binding glutamic acid-rich protein homolog
In allele shi-TS1; temperature sensitive larval and adult paralysis.
In allele shi-TS2; temperature sensitive larval and adult paralysis.
Probable cytochrome P450 12a5, mitochondrial
Vacuolar protein sorting-associated protein 72 homolog
Stimulator of interferon genes protein homolog
Eukaryotic translation initiation factor 3 subunit I
No effect on its function in maintaining muscle integrity.
In allele Smn-73Ao; homozygous lethal at late larval stages and abolishes homodimerization.
In allele Smn-B; homozygous lethal at late larval stages and abolishes homodimerization.
Rescues larval viability and locomotion defects and only partially restores U5 and U12 snRNA levels in the null mutant. Weakly inhibits homodimer formation. Does not affect protein stability.
Adenylyltransferase and sulfurtransferase MOCS3
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Dolichol-phosphate mannosyltransferase subunit 1
Tectonin beta-propeller repeat-containing protein
In nac1; abolishes GDP-fucose transport into the Golgi lumen. Shows lack of both core alpha-1,3- and alpha-1,6-linked fucose residues on N-glycans. Reduces neural expression of the HRP epitope. Does not affect subcellular localization to the Golgi apparatus.
Facilitated trehalose transporter Tret1-2 homolog
Abolishes mono-ADP-ribosylation and Sec body formation.
Protein mono-ADP-ribosyltransferase Parp16
Tumor necrosis factor receptor superfamily member wengen
Probable U3 small nucleolar RNA-associated protein 11
Mediator of RNA polymerase II transcription subunit 7
Putative protein kinase C delta type homolog
In P365; defective in the response to light due to rapid degeneration of photoreceptors.
In P365; photoreceptors respond normally to light.
Abolishes cardiolipin hydrolase activity.
In strain: =MEL01, MEL02, MEL11, MEL12, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398.
In strain: MEL20, ZBMEL131, ZBMEL186, ZBMEL384 and ZBMEL398.
In strain: ZBMEL191, ZBMEL229, ZBMEL377 and ZBMEL384.
In zuc(RS49); produce some eggs with a more normal eggshell phenotype in addition to the ventralized eggs compared to null mutants.
In zuc(SG63); produce some eggs with a more normal eggshell phenotype in addition to the ventralized eggs compared to null mutants.
Kelch domain-containing protein 10 homolog
Broad-complex core protein isoforms 1/2/3/4/5
Aryl hydrocarbon receptor nuclear translocator homolog
Depletion of microtubule network leading to axon loss; when associated with 233-A--A-236.
Depletion of microtubule network leading to axon loss; when associated with 262-A--A-265.
In isoform C, isoform D, isoform G and isoform I.
Microtubule elimination domain (MTED); Binds tubulin and blocks microtubule polymerization
Putative fatty acyl-CoA reductase CG8303
Recep_L_domain domain-containing protein
Mediator of RNA polymerase II transcription subunit 8
Inhibits zymogen cleavage and thus activation and spz processing.
Interchain (between light and heavy chains)
CCHC-type zinc finger nucleic acid binding protein
Solute carrier organic anion transporter family member 74D
Moderately delays development and reduces lifespan. In wing imaginal disks, increases its transcript level.
Regulator of nonsense transcripts 1 homolog
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Impaired cap1 2'-O-ribose methylation, siRNA biogenesis and RISC complex assembly. Flies are viable with no visible phenotype. No effect on miRNA biogenesis.
Dynein axonemal assembly factor 1 homolog
Eukaryotic translation initiation factor 3 subunit H
Threonylcarbamoyladenosine tRNA methylthiotransferase
Abolishes the ability to cause laterality defects upon overexpression.
Abolishes the ability to cause laterality defects upon overexpression; when associated with A-120 and A-166.
Abolishes the ability to cause laterality defects upon overexpression; when associated with A-120 and A-395.
Abolishes the ability to cause laterality defects upon overexpression; when associated with A-166 and A-395.
No effect on the ability to cause laterality defects upon overexpression.
Cyclic AMP response element-binding protein A
Eukaryotic translation initiation factor 5A
Potassium voltage-gated channel protein Shal
Mediator of RNA polymerase II transcription subunit 20
Disrupts mitochondrial function and results in enlarged mitochondria. Neurons present vacuolar lesions leading to neurodegeneration in the central brain. Results in behavioral defects and shorten lifespan.
NADH dehydrogenase (ubiquinone) 23 kDa subunit
Eukaryotic translation initiation factor 3 subunit C
Reduced activity and lack of response to Ras85D or rl stimulation.
Mitochondrial import inner membrane translocase subunit TIM14
Alpha N-terminal protein methyltransferase 1
Probable mitochondrial import inner membrane translocase subunit Tim17 4
NADPH:adrenodoxin oxidoreductase, mitochondrial
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
COP9 signalosome complex subunit 9 homolog
Probable 26S proteasome complex subunit sem1
In strain: Australia 2, Kenya 38, Kenya 43, Peru and USA 3.
Prevents binding to HP1 hinge domain but no effect on binding to HP1 chromoshadow domain.
Su(var)205-binding Pro-containing repeat 1
Su(var)205-binding Pro-containing repeat 2
Solute carrier family 35 member E1 homolog
No ventral furrow formation during gastrulation and reduced binding to CycA; when associated with A-86.
No ventral furrow formation during gastrulation and reduced binding to CycA; when associated with A-88.
Probable phosphorylase b kinase regulatory subunit beta
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Mediator of RNA polymerase II transcription subunit 12
Putative odorant receptor 69a, isoform A
Putative odorant receptor 69a, isoform B
Biogenesis of lysosome-related organelles complex 1 subunit 3
Glyceraldehyde-3-phosphate dehydrogenase 1
In strain: HFL23, HFL5, VT10, VT6 and HFL2.
Eukaryotic translation elongation factor 2
Nuclear envelope integral membrane protein
Abolishes interaction with GATA-type zinc fingers.
Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolish interaction with pnr.
Presenilins-associated rhomboid-like protein, mitochondrial
In Src42A-myri; 63% of mutants die during embryogenesis. In embryos, leading edge cell morphology is irregular, the actomyosin cable is disrupted and dorsal closure is delayed. Stage 16 embryos, which have undergone dorsal closure, have an irregular arrangement of epidermal cells.
E3 ubiquitin-protein ligase RNF181 homolog
In strain: Canton-S, KY02010G20, KY02013G20 and KY02073G20.
In strain: Canton-S, KY02010G20, KY02073G20 and KY02013G20.
In strain: Canton-S, KY02013G20 and KY02073G20.
Proton-coupled amino acid transporter-like protein CG1139
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Possible lysine-specific histone demethylase 1
Does not affect ion and sulfide binding.
Does not affect ion and sulfide binding. Results in a partial increase in mitochondrial DNA copy number.
In vitro, loss of hexamer formation. Loss of mitochondrial transcription. In vivo, results in significant decrease in complex IV activity, increase in apoptosis and a decrease in cell proliferation.
In vitro, loss of mitochondrial transcription. In vivo, significant decrease in complex IV activity, increase in apoptosis and a decrease in cell proliferation. In vivo, results in significant decrease in complex IV activity, increase in apoptosis and a decrease in cell proliferation.
In vitro, no effect on mitochondrial transcription. In vivo, moderate decrease in mtDNA levels in the third instar larval stage and slight decrease in longevity in the adult.
Loss of hexamer formation. Loss of mitochondrial transcription.
Loss of ion and sulfide binding and increased protein instability, retains DNA binding; when associated with A-102.
Loss of ion and sulfide binding and increased protein instability, retains DNA binding; when associated with A-105.
Loss of ion and sulfide binding, increased protein instability, partial increase in mitochondrial DNA copy number, retains DNA binding; when associated with A-68.
Loss of ion and sulfide binding, increased protein instability, retains DNA binding, partial increase in mitochondrial DNA copy number; when associated with A-71.
Loss of ion and sulfide binding; when associated with A-245.
Loss of ion and sulfide binding; when associated with A-248.
Modest reduction in mitochondrial DNA copy number.
No effect on mitochondrial transcription.
No increase in mitochondrial DNA copy number.
Partial increase in mitochondrial DNA copy number.
Potassium voltage-gated channel protein Shaw
Protein lethal(3)malignant blood neoplasm 1
Mitochondrial ribosome-associated GTPase 1
Protein transport protein Sec61 gamma-2 subunit
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Impairs function in completion of female meiosis. Loss of function in completion of female meiosis; when associated with A-215.
Loss of function in completion of female meiosis.
Loss of function in completion of female meiosis. Loss of function in completion of female meiosis; when associated with A-219.
No effect on function in completion of female meiosis.
Slightly impairs function in completion of female meiosis.
Loss of catalytic activity and dimerization.
Putative serine/threonine-protein kinase STE20-like
In psh1 and psh4; immune response defective. Reduced levels of Drs following immune challenge with fungal or bacterial proteases.
Muscle and wing mutant phenotype; allele flw-1.
Semi lethal, adult escapers exhibit muscle and wing mutant phenotype; allele flw-6.
Serine/threonine-protein phosphatase beta isoform
In strain: NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m12, NVIII-m15, NVIII-m19 and Oregon-R.
In strain: Oregon-R, Z145, Z266, Z346 and Z398.
Putative apoptosis-inducing factor 1, mitochondrial
Vacuolar protein sorting-associated protein 8 homolog
Complex I intermediate-associated protein 30, mitochondrial
Translation machinery-associated protein 7 homolog
Probable 28S ribosomal protein S25, mitochondrial
Highly reduced ectopic eye induction and diminishes degree of ommatidial restoration in eyeless phenotype rescue assay.
Thioredoxin-dependent peroxide reductase, mitochondrial
Eukaryotic translation initiation factor 3 subunit J
In strain: CAM-2, CAM-3, CAM-8, CAM-12, CAM-41, CAM-44, CAM-48 and Berkeley.
In strain: CAM-8, CAM-44, CAM-48 and Berkeley.
Abolishes homodimerization but not regulatory function on Slo; when associated with A-59.
Abolishes homodimerization but not regulatory function on Slo; when associated with A-63.
In rec3; temperature-sensitive allele. Recombination-defective.
Serine/threonine-protein phosphatase alpha-2 isoform
Queuine tRNA-ribosyltransferase catalytic subunit
Helical; Voltage-sensor; Name=S4 of repeat I
Helical; Voltage-sensor; Name=S4 of repeat II
Helical; Voltage-sensor; Name=S4 of repeat III
Helical; Voltage-sensor; Name=S4 of repeat IV
In QE70; defects in female meiosis. Abolishes DNA-binding activity.
In QQ36; defects in female meiosis. Abolishes DNA-binding activity.
5-glutamyl glycerylphosphorylethanolamine
Temperature-sensitive mutation; disrupts production of the steroid hormone ecdysone, causes developmental and reproductive defects.
MMS19 nucleotide excision repair protein
Angiotensin-converting enzyme-related protein
Putative tRNA pseudouridine synthase Pus10
Vacuolar protein-sorting-associated protein 25
In strain: Zim-F-S18, Zim-S-H32 and Zim-S-S2.
Mediator of RNA polymerase II transcription subunit 11
Rapamycin resistance and loss of activity.
In botv510; induces defects in wing patterning due to impaired movement of morphogens.
In botv514; induces defects in wing patterning due to impaired movement of morphogens.
In botv8; induces defects in wing patterning due to impaired movement of morphogens.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
BLOC-1-related complex subunit 8 homolog
Malignant T-cell-amplified sequence 1 homolog
No effect on translation regulation activity.
No effect on translation regulation activity. Reduced translation regulation activity; when associated with A-119.
Reduced translation regulation activity. Further reduced translation regulation activity; when associated with A-119.
Mediator of RNA polymerase II transcription subunit 22
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Ankyrin repeat and LEM domain-containing protein 2 homolog
Pupal lethality at temperatures above 22 degrees Celsius. Larvae initially have normal brain sizes, but later in the third larval stage, the brain is smaller than in wild-type counterparts.
Dual specificity mitogen-activated protein kinase kinase hemipterous
C-1-tetrahydrofolate synthase, cytoplasmic
Proteasome-associated protein ECM29 homolog
Immediate early response 3-interacting protein 1
Mitochondrial proton/calcium exchanger protein
Conserved oligomeric Golgi complex subunit 5
In strain: CT97_3, MFL97_1 and ZIM(S)37.
Nuclear pore complex protein Nup160 homolog
Does not affect subcellular location. Loss of catalytic activity.
Polypeptide N-acetylgalactosaminyltransferase 3
Signal transducer and transcription activator
H/ACA ribonucleoprotein complex subunit 4
Abolishes interaction with eIF4E1; when associated with 586-A-A-587.
Abolishes interaction with eIF4E1; when associated with A-581.
Eukaryotic translation initiation factor 4E-binding protein Mextli
Fork head domain transcription factor slp1
Abolishes in vitro phosphorylation by LIMK1. Partial rescue of both the defective neuroblast proliferation and defective axon growth seen in null mutants.
Cofilin/actin-depolymerizing factor homolog
Defective distal orientation of wing hairs and incorrect localization of the planar cell polarity proteins fz and stan/fmi; when associated with 139-AAALA-143.
Defective distal orientation of wing hairs and incorrect localization of the planar cell polarity proteins fz and stan/fmi; when associated with Q-27.
No rescue of the defective neuroblast proliferation seen in null mutants but partial rescue of the defective axon growth.
39S ribosomal protein L41, mitochondrial
COA8 family protein CG14806, mitochondrial
In xmas-2-C; no effect on interaction with Orc3.
In xmas-2-N; abolishes interaction with Orc3.
In xmas-2-dCID; no effect on interaction with Orc3.
In xmas-2-dM; no effect on interaction with Orc3.
In xmas-2-dRRM; no effect on interaction with Orc3.
Increased phosphatidic acid binding but no effect on phosphatidylinositol binding or transfer activity.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Lack of heparan sulfate glycosaminoglycan modification. Does not affect binding to nord; when associated with A-549 and A-569.
Lack of heparan sulfate glycosaminoglycan modification. Does not affect binding to nord; when associated with A-549 and A-573.
Lack of heparan sulfate glycosaminoglycan modification. Does not affect binding to nord; when associated with A-569 and A-573.
O-linked (Xyl...) (heparan sulfate) serine
Enhances protein stability. Does not affect protein distribution in the oocyte.
Increase in RNA-binding and no significant change to RNA-dependent ATPase or unwinding activities.
Moderately decreased the RNA binding, abolished both the RNA-dependent ATPase and unwinding activities.
No change to RNA-binding, abolished unwinding activities and no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, abolished unwinding activities and no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, barely detectable RNA-dependent ATPase activity and completely defective unwinding activity.
Reduction in RNA-binding, drastic reduction in unwinding activities and no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, drastic reduction in unwinding activities, no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, reduced RNA-dependent ATPase and unwinding activities.
Reduction in RNA-binding, significantly reduced RNA-dependent ATPase and unwinding activities.
Strongly decreases interaction with gus.
Activity-regulated cytoskeleton associated protein 2
Probable cytochrome P450 12e1, mitochondrial
Transcription initiation factor TFIID subunit 4
In Dif1; immune response defective. Reduced survival following infection with fungi, and reduced levels of Drs following immune challenge with fungi or bacteria. No down-regulation of the serpin Spn27A in response to bacterial infection. Ectopic bristles form on the dorsocentral, scutellar and lateral regions of the notum.
Alpha/beta-tubulin-N-acetyltransferase 9
In AAA; overexpression results in a weak thorax cleft.
In AcDel; overexpression results in a weak thorax cleft. Microtubule polymerization activity is slightly reduced.
HEAT repeat-containing protein 1 homolog
Transient receptor potential cation channel protein painless
Probable phenylalanine--tRNA ligase, mitochondrial
ATP-dependent zinc metalloprotease YME1L
Loss of DNA-binding. Does not affect function in vivo; when associated with A-158 and A-166.
Loss of DNA-binding. Does not affect function in vivo; when associated with A-158 and A-185.
Loss of DNA-binding. Does not affect function in vivo; when associated with A-166 and A-185.
Histone deacetylase complex subunit SAP18
Vacuolar protein sorting-associated protein 26
cAMP-dependent protein kinase catalytic subunit 1
In bratfs3; induces production of tumor-like neoplasms in the larval brain. Disrupts interaction with nos and pum.
In bratts1; induces production of tumor-like neoplasms in the larval brain. Disrupts interaction with nos and pum.
GATA zinc finger domain-containing protein 14-like
Gly-cisPro motif, important for rejection of L-amino acids
Eukaryotic translation initiation factor 3 subunit E
Protein-serine O-palmitoleoyltransferase porcupine
Abolishes RNA-binding; when associated with 236-A--A-240.
Abolishes RNA-binding; when associated with A-210.
Reduces binding to Panx, increases cytoplasmic localization and increases transposon expression after loss of gene.
Retains localization to the nucleus and interaction with Panx but reduces interaction with Nxt1. Increases transposon expression after loss of gene.
Retains localization to the nucleus and interaction with Panx. Increases transposon expression after loss of gene.
Retains localization to the nucleus and interaction with Panx. Reduces transposon expression after loss of gene.
Abolishes binding to human SELENOF/SEP15.
Destabilizes protein structure and targets it for degradation.
UDP-glucose:glycoprotein glucosyltransferase
Constitutively associates with the 40S ribosomal subunit.
Does not affect development. Viable but with reduced body and bristle size; when associated with L-38 or T-77.
Embryonic lethal. Viable but with reduced body and bristle size; when associated with L-146.
Larval lethal. Viable but with reduced body and bristle size; when associated with L-146.
CDGSH iron-sulfur domain-containing protein 2 homolog
In isoform A, isoform B, isoform H and isoform I.
Abolishes interaction with nxf2 and decreases protein stability.
Zinc finger CCCH domain-containing protein 15 homolog
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Rab3 GTPase-activating protein non-catalytic subunit
Calcium uptake protein 1 homolog, mitochondrial
Abolishes interaction with me31B and impairs translational repression and induction of mRNA decay.
In C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-58 and A-60.
In C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-58 and a-65.
In C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-60 and a-65.
In FF; abolishes interaction with me31B; when associated with A-361.
In FF; abolishes interaction with me31B; when associated with A-367.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-582 and A-590.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-582,and A-596.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-590 and A-596.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-582, A-590 and A-596.
Extracellular serine/threonine protein kinase four-jointed
In allele wg-IL114; temperature sensitive lethal.
Intermembrane lipid transfer protein Vps13D
Loss of 'Lys-63'-linked polyubiquitin chain binding.
In strain: MelZim1, MelZim3, MelZim4, MelZim5, MelZim6 and MelZim7.
In strain: MelZim1, MelZim4, MelZim5 and MelZim6.
In strain: MelZim1, MelZim5 and MelZim6.
Displays defects in aligning on the meiotic spindle.
N-linked (GlcNAc...) (complex) asparagine
N-linked (GlcNAc...) (complex) asparagine; alternate
N-linked (GlcNAc...) (high mannose) asparagine
N-linked (GlcNAc...) (high mannose) asparagine; alternate
N-linked (GlcNAc...) (paucimannose) asparagine
N-linked (GlcNAc...) (paucimannose) asparagine; alternate
Schiff-base intermediate with dihydroxyacetone-P
Transcription elongation factor 1 homolog
In strain: Draveil, Loua, Monty5, P.bourg, Tahiti, Texas and ZW141.
Set1/Ash2 histone methyltransferase complex subunit ASH2
Abolishes interaction with cup and mxt; when associated with A-107.
Abolishes interaction with cup and mxt; when associated with A-123.
Abolishes interaction with mxt, reduces binding to Thor and 4E-T, and does not affect interaction with cup.
Disrupts interaction with cup, eIF4G and mxt.
Eukaryotic translation initiation factor 4E1
Trafficking protein particle complex subunit 10
Transmembrane protein 11 homolog, mitochondrial
Transcription initiation factor TFIID subunit 9
Death-associated inhibitor of apoptosis 1
Organic solute transporter alpha-like protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
In Z2217; Impairs cytokinesis. Prevents binding to PI(4)P and PI(5)P.
Prevents binding to PI(4)P and abolishes sau localization to the Golgi membranes and cleavage furrow; when associated with A-167.
Prevents binding to PI(4)P and abolishes sau localization to the Golgi membranes and cleavage furrow; when associated with L-170.
Partial loss of transport activity and increased sensitivity to blocking by the magnesium ion.
Coiled-coil and C2 domain-containing protein 2A
Cullin-associated NEDD8-dissociated protein 1
Cyclin-dependent kinases regulatory subunit
In 3B20; probable loss of function. The lumen of separate tracheal branches fails to fuse during anastomosis and Syx1A does not localize to the fusion point.
Elongation of very long chain fatty acids protein 7
Little effect on binding to liposomes, phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate.
Loss of binding to liposomes containing phosphoinositides. In contrast to wild-type protein whose expression largely rescues mutant phenotypes, expression in mutant neurons only partially rescues the increase in synapse mobility and the abherent accumulation of large cisternal or endosomal-like structures in pre-synaptic terminals observed in mutants. In addition, the number of mutants displaying defective motor coordination, defective flight, hyperactivity, increased temperature sensitivity and seziures is increased compared to mutants expressing wild-type protein.
Reduced binding to liposomes under low phosphatidylinositol 4,5-bisphosphate (PIP2) concentrations. Reduced binding to inositol 1,4,5-trisphosphate (IP3). In contrast to wild-type, expression only partially rescues the accumulation of sub-boutonic foci.
ATP synthase subunit beta, mitochondrial
Abolishes interaction with Edc3; when associated with A-281; A-284 and A-288.
Abolishes interaction with Edc3; when associated with A-281; A-284 and A-292.
Abolishes interaction with Edc3; when associated with A-281; A-288 and A-292.
Abolishes interaction with Edc3; when associated with A-284; A-288 and A-292.
In CL-AA; reduced interaction with Gyf and Patr-1 but has no effect on interaction with 4E-T; when associated with A-285.
In CL-AA; reduced interaction with Gyf and Patr-1 but has no effect on interaction with 4E-T; when associated with A-289.
In LK-AA; reduced interaction with Gyf, Patr-1 and 4E-T; when associated with A-310.
In LK-AA; reduced interaction with Gyf, Patr-1 and 4E-T; when associated with A-314.
Pre-mRNA-splicing regulator female-lethal(2)D
Impairs chromo domain folding and histone H3 binding. Does not affect piwi binding.
Chromosome transmission fidelity protein 18 homolog
Transient receptor potential channel pyrexia
Serine/threonine-protein phosphatase 2B catalytic subunit 1
In strain: Berkeley, JP-5, JP-35, JP-55, JP-65 and KN-12.
In strain: Berkeley, JP-5, JP-35, JP-55, JP-65, JP-70, KN-12 and KN-21.
In strain: Berkeley, JP-5, JP-35, JP-55, JP-75, KN-12 and Oregon-R.
In strain: JP-1, JP-15, JP-84, KO140 and KN-27.
In strain: JP-75, KN-17, KN-21, KN-22 and L16.
Eukaryotic translation initiation factor 3 subunit G-1
ADP-ribosylation factor-like protein 6-interacting protein 1
Dimethyladenosine transferase 2, mitochondrial
Potassium voltage-gated channel protein eag
Reduced eag channel amplitude and accelerated inactivation. Does not affect binding with CASK.
Transcriptional activator cubitus interruptus
Transcriptional repressor cubitus interruptus
39S ribosomal protein L32, mitochondrial
39S ribosomal protein L35, mitochondrial
Inhibits interaction with Rac1 but not Rho1, does not alter subcellular localization and is able to rescue loss-of-function phenotype lethality.
Bifunctional arginine demethylase and lysyl-hydroxylase PSR
Abolishes enzyme activity but no effect on protein folding nor secretion; when associated with A-442.
Abolishes enzyme activity but no effect on protein folding nor secretion; when associated with A-443.
GDP-fucose protein O-fucosyltransferase 2
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Peptidylglycine alpha-hydroxylating monooxygenase
Third instar larval lethal. First and second instar larvae are reduced in size.
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Biogenesis of lysosome-related organelles complex 1 subunit 4
Abolishes cleavage from sperm and prevents release of C-terminal fragment for long-term PMR. Short-term PMR in unaffected.
Complete loss of activity; when associated with A-42. Complete loss of activity; when associated with A-42; A-43 and A-55.
Complete loss of activity; when associated with A-42; A-43 and A-51.
Complete loss of activity; when associated with A-42; A-51 and A-55.
Complete loss of activity; when associated with A-51. Complete loss of activity; when associated with A-43; A-51 and A-55.
In strain: Berkeley, M2, M26, M36, M40, M55 and SFS 3.4.
N-acetylglucosamine-6-phosphate deacetylase
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
In mus205; hypersensitive to alkylating agents and UV, but not sensitive to ionising radiation. In somatic cells, no effect on methyl methane sulfonate-induced mutations and homologous recombination. In germ cells, no effect on mutability by X-rays, NQO and alkylating agents.
Complete loss of activity; when associated with A-67.
Complete loss of activity; when associated with A-74.
Reduced activation of SPR; when associated with A-202.
Dimethyladenosine transferase 1, mitochondrial
In strain: 2CPA1, 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105.
In strain: 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105.
Decreases sleep latency; when associated with S-301.
Gamma-aminobutyric acid receptor subunit beta
In RNA edited version; does not alter GABA receptor activity; retains inhibition by picrotoxin; shows resistance to picrotoxinin; when associated with S-301.
Reduces in-current for inward flow of chloride ions, results in slower and incomplete desensitization which ultimately increases single channel open durations. Resistant to picrotoxinin (PTX) and cyclodiene dieldrin insecticides. Retains partial sensitivity to TBPS and lindane. Decreases sleep latency, increases total sleep time and shows resistance to carbamazepine sleep-induced effects on sleep both by itself or when associated with I-360. Restores defective sleep in Nlg4 and Lztr1 mutants. Retains resistance to picrotoxinin; when associated with V-283.
MAP kinase-activating death domain protein
Ecdysone-induced protein 75B, isoforms C/D
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
In vnd-29; disrupts neuroblast development.
Causes the differentiation of ectopic vein stretches in several regions of the wing. Shows elimination of distal stretches of longitunal veins L2-L5. Causes substitution of the wing by proximal hinge tissue. Affects the development of macrochaetae or the formation of the thorax.
Dual specificity protein phosphatase Mpk3
Reduces binding affinity to substrate by approximately 18-fold.
Cytochrome c oxidase subunit 7A, mitochondrial
In ncd(D); reduces motor velocity and shows abnormal chromosomal segregation.
Abolishes glycosyltransferase activity. Not able to rescue lethality caused by SF32 mutation.
Polypeptide N-acetylgalactosaminyltransferase 35A
Coiled-coil domain-containing protein 130 homolog
In CJ101; larvae lethal. In egg chambers, follicle cells (FC) display abnormal localization of various apical, junctional and basolateral proteins, and loss of epithelial integrity. In follicle epithelium (FE) cells, the basal membrane proteins, trol, Lam and vkg display abnormal localization; accumulating on the apical side of the cell in addition to the normal basal accumulation. Expression of strat in the FE is reduced. In egg chambers, trol also shows abnormal apical localization at the posterior pole. Many FCs appear irregularly shaped at the poles, form multiple layers and are often found in the germline cluster. FCs on the lateral side however, appear normal.
Larvae lethal at the L2 stage. Adult flies display subtle defects in ommatidial organization.
Larvae lethal at the L2 stage. In photoreceptor cells, light-induced accumulation of newly synthesized ninaE (Rh1) post-Golgi vesicles leads to a reduction in membrane stack volume, and eventually, photoreceptor cell degeneration. Disruption of photoreceptor cell function is light- and age-dependent.
In strain: IS2, IS3, IS4, IS5, IS25 and QD18.
Loss of enzymatic activity. Increased susceptibility to infections by E.cloacae. No effect on binding and polyubiquitination of imd.
Probable ubiquitin carboxyl-terminal hydrolase FAF
Superoxide dismutase [Mn], mitochondrial
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
In isoform A, isoform B, isoform G and isoform H.
Loss of thioredoxin-dependent activity, 80% DTT-dependent activity.
Loss of thioredoxin-dependent activity, 81% DTT-dependent activity.
Loss of thioredoxin-dependent activity, 85% DTT-dependent activity.
Thioredoxin-dependent activity reduced, but no change in DTT-dependent activity.
Dynein axonemal assembly factor 3 homolog
Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
No effect on VLCA levels. Increases dimerization. Induces a high level of ROS and severe axonal loss. Lethal.
Probable peroxisomal acyl-coenzyme A oxidase 1
Adrenodoxin-like protein 2, mitochondrial
Probable multidrug resistance-associated protein lethal(2)03659
In 3A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-656 and A-660.
In 3A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-656 and A-664.
In 3A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-660 and A-664.
In 3D; phosphomimetic mutant that displays a slight decrease in phospholipid binding and reduced cortical localization; when associated with D-656 and D-660.
In 3D; phosphomimetic mutant that displays a slight decrease in phospholipid binding and reduced cortical localization; when associated with D-656 and D-664.
In 3D; phosphomimetic mutant that displays a slight decrease in phospholipid binding and reduced cortical localization; when associated with D-660 and D-664.
In 4k/R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with 658-D--D-659.
In 4k/R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with D-666 and D-667.
Probable E3 ubiquitin-protein ligase sinah
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho
In D-mib4; induces defects in Notch signaling.
In dor-1; diminished fertility and an orange eye color.
In dor-30; Accumulation of the mature form of Cp1.
In dor-36; reduced endolysosomal trafficking and thus reduced number of effective vesicles released in response to a nerve impulse (quantal content). This is likely largely due to the reduction in readily releasable vesicles. Accumulation of the mature form of Cp1. Expression in sky mutants partially rescues increased neurotransmitter release at the larval neuromuscular junction and neurodegeneration in the retina. However it does not rescue the excessive recycling of vesicles to endosomal compartments in sky mutants.
Vacuolar protein sorting-associated protein 18 homolog
Nascent polypeptide-associated complex subunit alpha
Proteasomal ubiquitin receptor ADRM1 homolog
In vir1ts; transforms XX animals into intersexes at 29 degrees Celsius.
In vir2f; XX-specific lethal, interferes with sex determination and dosage compensation.
Probable RNA 3'-terminal phosphate cyclase-like protein
Serine/threonine-protein phosphatase 6 catalytic subunit
Cytochrome c oxidase subunit 5A, mitochondrial
Transcription elongation factor B polypeptide 3
Serine/threonine-protein phosphatase PP-Y
Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-3 and G-8.
Decreases but does not prevent tal-dependent cleavage. Abolishes tal-dependent cleavage; when associated with G-8. Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-8 and G-28.
In ovo-D1; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected.
In ovo-D2; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected.
In ovo-D3; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected.
No effect on tal-dependent cleavage. Abolishes tal-dependent cleavage; when associated with G-3. Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-3 and G-28.
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Strongly reduces ability to activate mth.
In mtSSB45-1; significant reduction in mitochondrial DNA (mtDNA) copy number and reduced recovery of mtDNA depletion induced by ethidium bromide.
In mtSSB45-2; reduced mitochondrial DNA (mtDNA) copy number and reduced recovery of mtDNA depletion induced by ethidium bromide.
In mtSSBalpha1; significant reduction in mitochondrial DNA (mtDNA) copy number and reduced recovery of mtDNA depletion induced by ethidium bromide.
In mtSSBloop12; significant reduction in mitochondrial DNA copy number.
In mtSSBloop23; significant reduction in mitochondrial DNA copy number. No effect on ability to stimulate the activity of the polymerase PolG1.
No decrease in DNA synthesis by the polymerase PolG1. Severe decrease DNA synthesis by the polymerase PolG1 and decreased DNA binding; when associated with T-85.
No effect on DNA synthesis by the polymerase PolG1.
Reduced DNA synthesis by the polymerase PolG1.
Reduced DNA synthesis by the polymerase PolG1. Severe decrease in the stimulation of DNA synthesis by the polymerase PolG1 and decreased DNA binding; when associated with A-91.
Single-stranded DNA-binding protein, mitochondrial
Abolishes methyltransferase activity of the Esc/E(z) complex.
Strongly reduces methyltransferase activity of the Esc/E(z) complex.
Loss of kinase activity. Attenuates bsk activation.
Mitogen-activated protein kinase kinase kinase
Proton-coupled amino acid transporter-like protein pathetic
Increases Ca(2+) influx through activation of CRAC channels and arrests cell growth.
Succinate dehydrogenase assembly factor 4, mitochondrial
Cyclic nucleotide-gated cation channel subunit A
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
Staphylococcal nuclease domain-containing protein 1
In mus308-094 mutant; mutant females produce ventralized egg shells.
In mus308-2255 mutant; mutant females produce ventralized egg shells; when associated with D-455.
In mus308-2255 mutant; mutant females produce ventralized egg shells; when associated with H-811.
In mus308-660 mutant; mutant females produce ventralized egg shells.
Putative inactive tyrosine-protein kinase Wsck
WD repeat-containing and planar cell polarity effector protein fritz
3-phosphoinositide-dependent protein kinase 1
Abolishes interaction with PCNA and subsequent degradation by the proteasome.
Enhances interaction with mbt. Coexpression with mbt slightly reduced the substrate phosphorylation ability of mbt.
Signal recognition particle receptor subunit alpha homolog
Neural/ectodermal development factor IMP-L2
Basic helix-loop-helix neural transcription factor TAP
In bowl2; embryonic lethal. Legs containing clones show fusion and truncation of tarsomeres and disrupted expression of the leg patterning genes bab2, dac and B-H1.
In bowl4; embryonic lethal with 50% larval/pupal escapers.
In bowl5; embryonic lethal; when associated with I-343 and K-345.
In bowl5; embryonic lethal; when associated with I-343 and P-609.
In bowl5; embryonic lethal; when associated with K-345 and P-609.
Cysteinyl-selenocysteine (Cys-Sec); redox-active
Protein phosphatase PP2A 55 kDa regulatory subunit
Probable G-protein coupled receptor Mth-like 9
In strain: Canton-S, G02, G130 and G140.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
Probable rRNA-processing protein EBP2 homolog
Chromodomain-helicase-DNA-binding protein 1
DNA-directed RNA polymerase II subunit RPB1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Ribosomal L1 domain-containing protein CG13096
In mei-41D12; induces a weak sensitivity to methanesulfonate.
In mei-41D14; induces some sensitivity to methanesulfonate.
In mei-41D15; induces some sensitivity to methanesulfonate.
In mei-41D3; induces a very strong sensitivity to methanesulfonate and female infertility.
In mei-41D5; induces a strong sensitivity to methanesulfonate.
In mei-41D9; induces some sensitivity to methanesulfonate.
Probable ATP-dependent RNA helicase DDX55 homolog
Probable Rho GTPase-activating protein CG5521
Nitric oxide synthase-interacting protein homolog
Embryonic lethal and displays defects in primary tracheal branching and Malpighian morphogenesis. Displays abnormal splicing of zygotic transcripts resulting in qualitative (intron retention) as well as quantitative (transcript abundance) changes in gene expression. Tracheal defects are likely due, at least in part, to the mis-splicing of bnl transcripts. Embryonic Malpighian tubules are shortened and round.
Fand1; a large subset of zygotic but not maternally encoded pre-mRNAs, including the kuk transcript, display splicing defects. Consequently, maternally controlled oogenesis, such as primordial germ-cell formation and syncytial nuclear divisions, appear normal but during zygotically controlled blastoderm cellularization the cortical nuclei fail to elongate and become mislocalized. Reduced protein levels of ISY1/CG9667 but no effect on Prp19.
Fand2; embryos display significant splicing defects in the small zygotic kuk transcript whereas there is no effect on splicing of the large maternal kuk transcript. Reduced protein levels of ISY1/CG9667 but no effect on Prp19.
H124; embryonic lethal and displays defects in primary tracheal branching. Tracheal defects are likely due at least in part, to the mis-splicing of bnl transcripts. Earlier developmental processes, such as gastrulation and germband retraction are unaffected.
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Does not affect binding to Elongin BC complex or vas.
Does not affect binding to Elongin BC complex. Abolishes interaction with vas.
Does not affect binding to Elongin BC complex. Decreases interaction with vas.
Peptidyl-prolyl cis-trans isomerase Fkbp12
Defects in sensory bristle formation and wing shape, and oogenesis. Non-functional; when associated with A-10.
Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-170.
Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-173.
Non-functional; when associated with A-89.
In allele Shab-1; temperature-sensitive paralytic.
Potassium voltage-gated channel protein Shab
Glycine cleavage system H protein, mitochondrial
Histone deacetylase complex subunit SAP30 homolog
DnaJ homolog subfamily C member 25 homolog
Probable trafficking protein particle complex subunit 2
In strain: Oregon-R, NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial
No effect on lethality; when associated with A-831.
No effect on lethality; when associated with A-843.
Rescues dorsal closure defect, muscle attachment defect, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-817.
Rescues dorsal closure defect, muscle attachment defects, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-807.
Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-811.
Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-814.
39S ribosomal protein L11, mitochondrial
Reduces ability to repress transposon levels. Unable to rescue spermatogenesis defects in null mutants. Rescues germ stem cells defects in null mutants.
Mediator of RNA polymerase II transcription subunit 10
Impairs binding to histone H3 and histone H4 and transcriptional silencing.
Eukaryotic translation initiation factor 5
Tubulin polymerization-promoting protein homolog
Abolished binding to nucleic acid activator, leading to impaired antiviral immunity; when associated with E-256.
Abolished binding to nucleic acid activator, leading to impaired antiviral immunity; when associated with E-267 or E-271.
Interleukin enhancer-binding factor 2 homolog
Polypeptide N-acetylgalactosaminyltransferase 1
Eukaryotic translation initiation factor 2 subunit 1
Tetratricopeptide repeat protein 36 homolog
Fibroblast growth factor receptor homolog 1
MICOS complex subunit MIC13 homolog QIL1
Probable small nuclear ribonucleoprotein G
Probable small nuclear ribonucleoprotein Sm D1
Nucleolar MIF4G domain-containing protein 1 homolog
Exonuclease 3'-5' domain-containing protein 2
In isoform 2, isoform 3, isoform 5 and isoform 6.
In isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7.
Abolishes N-alpha-acetyltransferase activity; impaired sister chromatid cohesion during mitosis.; when associated with A-84.
Abolishes N-alpha-acetyltransferase activity; impaired sister chromatid cohesion during mitosis.; when associated with F-124.
Cilia- and flagella-associated protein 298
WW domain-containing adapter protein with coiled-coil homolog
Calcium/calmodulin-dependent protein kinase type II alpha chain
Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-306.
Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-307.
Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-306.
Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-307.
Fails to interact with CASK, kinase inactive, when associated with D-306.
Fails to interact with CASK, kinase inactive, when associated with D-307.
Affects phosphorylation and localization to centromeres.
Does not stably associate with centromeres during mitosis.
In mei-S332-10; induces missegregation of chromatids during meiosis.
In mei-S332-2; induces missegregation of chromatids during meiosis.
In mei-S332-3; induces missegregation of chromatids during meiosis.
In mei-S332-4; induces missegregation of chromatids during meiosis; when associated with H-.
In mei-S332-4; induces missegregation of chromatids during meiosis; when associated with M-112.
In mei-S332-5; induces missegregation of chromatids during meiosis.
In mei-S332-6; induces missegregation of chromatids during meiosis.
In mei-S332-8; induces missegregation of chromatids during meiosis.
In mei-S332-9; induces missegregation of chromatids during meiosis.
Tyrosine-protein kinase transmembrane receptor Ror2
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
39S ribosomal protein L28, mitochondrial
Extracellular serine/threonine protein CG31145
Transcription initiation factor IIA subunit 2
Blocks ability of fj to enhance binding to ds.
In ft61; strong overgrowth of eye imaginal disks. Binding to Fbxl7 is not affected.
Adrenodoxin-like protein 1, mitochondrial
H/ACA ribonucleoprotein complex subunit 2-like protein
Probable DNA-directed RNA polymerases I and III subunit RPAC2
Post-GPI attachment to proteins factor 2
Probable 39S ribosomal protein L24, mitochondrial
S-adenosylmethionine mitochondrial carrier protein homolog
Uncharacterized zinc finger protein CG12744
Pterin-4-alpha-carbinolamine dehydratase
Regulator of telomere elongation helicase 1 homolog
For molybdenum cofactor biosynthesis protein C activity
Molybdenum cofactor biosynthesis protein 1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P
Abolishes enzymatic activity; no change in interaction with MAD.
Abolishes interaction with MAD; when associated with A-544.
Abolishes interaction with MAD; when associated with F-541.
cAMP-dependent protein kinase catalytic subunit 3
In imd-1; immune response defective. Reduced survival and decreased induction of various antibacterial peptides after bacterial challenge. Abolishes ubiquitination and reduces binding to Diap2 but has no effect on caspase-mediated cleavage. Increased resistance to UV radiation. No effect on survival after infection with the fungus A.fumigatus. No effect on up-regulation of Drs after bacterial challenge.
Loss of function. Abolishes caspase-mediated cleavage and ubiquitination. Blocks expression of Dpt in response to E.coli peptidoglycans (PGN).
39S ribosomal protein L13, mitochondrial
Basic helix-loop-helix transcription factor amos
Histone-lysine N-methyltransferase PR-Set7
Decreases mRNA deadelynation and decay; when associated with A-491.
Decreases mRNA deadelynation and decay; when associated with A-493.
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Probable ribosome biogenesis protein RLP24
Gamma-aminobutyric acid receptor alpha-like
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2
non-specific serine/threonine protein kinase
Unconventional prefoldin RPB5 interactor-like protein
Results in eye color defects caused by oversized pigment granules; when associated with 2772-W--K-3535.
Results in eye color defects caused by oversized pigment granules; when associated with 3160-W--K-3535.
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
Ribosomal RNA processing protein 1 homolog
Calcium-activated potassium channel slowpoke
In isoform 2, isoform 3, isoform 5, isoform 6 and isoform M.
In isoform 5, isoform C, isoform H, isoform O, isoform P and isoform Q.
In isoform 6, isoform E, isoform P and isoform Q.
In isoform A, isoform D, isoform E, isoform F, isoform H, isoform M and isoform Q.
Conserved oligomeric Golgi complex subunit 3
Putative epidermal cell surface receptor
Probable ATP-dependent RNA helicase kurz
Succinate dehydrogenase assembly factor 2-A, mitochondrial
In rogdi(del); greatly reduced protein half-life; localization to distinct cytoplasmic inclusions; insomnia-like behaviors with sleep fragmentation and delay in sleep initiation in males and virgin females but not in mated females.
Serine/threonine-protein phosphatase 2B catalytic subunit 2
Mitochondrial import inner membrane translocase subunit TIM50-C
PTB domain-containing adapter protein ced-6
Serine/threonine-protein phosphatase 4 catalytic subunit
Abolishes phosphorylation. Reduces kinase activity.
tRNA (guanine(26)-N(2))-dimethyltransferase
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Probable cytosolic Fe-S cluster assembly factor CG17683
DNA polymerase subunit gamma-1, mitochondrial
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in larval lethality at the third instar stage. Displays increased exonuclease activity and shows replicative stalling, particularly at dATP insertion sites. Defective replication and synthesis results in decreased levels of mtDNA but does not result in multiple linear deletions in mtDNA. No effect on DNA binding.
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in larval lethality at the third instar stage. Larvae 5 days old, display a severe decrease in mtDNA levels and a significant reduction in body weight. Does not result in linear deletions of mtDNA.
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in pupal lethality. Only half of the mutants survive to the pupal stage but die shortly afterwards. Larvae display an accumulation of point mutations and linear deletions of mtDNA. No decrease in larvae body weight. Unable to rescue the defective clearance of paternal mitochondrial nucleoids in mutants.
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in the death of most mutants at the third instar stage. Only two percent survive to the pupal stage but die shortly afterwards. Five day old larvae display a severe decrease in mtDNA levels and a significant reduction in body weight.
In KDF; reduction in polymerase activity.
In PKL; severe reduction in polymerase activity.
In SYW; severe reduction in polymerase activity.
In YED; slight reduction in polymerase activity.
Loss of mitochondrial DNA which disrupts mitochondrial morphology, leads to higher mitochondrial density in proximal nerves and muscles as well as increased flux of bidirectional mitochondrial axonal transport; when associated with Ala-595.
Loss of mitochondrial DNA which disrupts mitochondrial morphology; larval brains are smaller due to defective cell proliferation leading to death at the pupal stage. Leads to higher mitochondrial density in proximal nerves and muscles as well as increased flux of bidirectional mitochondrial axonal transport; when associated with 1085-S--S-1145 DEL.
Partially rescues the defective clearance of paternal mitochondrial nucleoids in mutants.
Severe defects in mitochondrial DNA (mtDNA) replication and synthesis results in larval lethality at the third instar stage. Exonuclease activity is increased, and displays replicative stalling, particularly at dATP insertion sites, and decreased DNA binding. Defective replication and synthesis results in decreased levels of mtDNA but does not result in multiple linear deletions in mtDNA.
Severe reduction in polymerase activity.
Slight reduction in polymerase activity.
Thioredoxin reductase-like selenoprotein T homolog CG3887
Putative inactive polypeptide N-acetylgalactosaminyltransferase 12
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
DNA repair protein complementing XP-A cells homolog
Nuclear distribution protein nudE homolog
Putative inactive polypeptide N-acetylgalactosaminyltransferase 11
Coiled-coil domain-containing protein lobo
Probable G-protein coupled receptor Mth-like 3
In ter94-26-8; arrests early in oogenesis.
Transitional endoplasmic reticulum ATPase TER94
In strain: Berkeley, Oregon-R and Oregon-R(2/10).
Mitochondrial import inner membrane translocase subunit TIM50-B
Guanine nucleotide exchange factor subunit Rich
In strain: NVIII-2, NVIII-5 and NVIII-m15.
Decreased inhibition of proteolytic activation of phenoloxidase (PO).
Fails to inhibit proteolytic activation of phenoloxidase (PO).
Ovarian-specific serine/threonine-protein kinase Lok
Probable DNA replication complex GINS protein PSF2
Abolishes interaction with polo and ability to maintain G2 arrest.
Decreased degradation during the oocyte-to-embryo transition.
In strain: NC335, NC390, NC397 and NC774.
No effect on degradation during the oocyte-to-embryo transition.
No effect on degradation during the oocyte-to-embryo transition; when associated with A-193.
No effect on degradation during the oocyte-to-embryo transition; when associated with A-95.
Phosphomimetic mutant which displays a decrease in the number of mitotic cells.
Prevents phosphorylation and displays an increase in the number of mitotic cells.
Non-canonical poly(A) RNA polymerase protein Trf4-1
Mediator of RNA polymerase II transcription subunit 24
Beta-alanyl-dopamine/carcinine hydrolase
Beta-alanyl-dopamine/carcinine hydrolase alpha subunit
Beta-alanyl-dopamine/carcinine hydrolase beta subunit
Impairs self-processing. Does not affect homodimerization of the unprocessed form. Loss of carcinine hydrolysis.
In tan1 and tan4; impairs self-processing. Loss of beta-alanyl-dopamine hydrolysis. Lighter pigmentation of the body. In newly emerged female imagoes and fly frass, beta-alanyl-dopamine (NBAD) levels are increased about 3-fold while dopamine levels are reduced by 50 percent. Reduces head histamine contents. Increases carcinine levels. Photoreceptor response to light is abnormal. Electroretinogram (ERG) recordings lack normal 'on' and 'off' transients suggesting an impaired synaptic transmission to postsynaptic cells. Reduces number of synaptic vesicles at the terminal of photoreceptor cells L1-L6.
In tan5; reduces stability resulting in rapid protein degradation. 4-fold increase in affinity for carcinine. No effect on self-processing.