Aspartate carbamoyltransferase regulatory chain
Nascent polypeptide-associated complex protein
Resolvase/invertase-type recombinase catalytic
Glutamyl-tRNA(Gln) amidotransferase subunit E
1,4-alpha-glucan branching enzyme TK1436
Involved in ionization of N3 of dUMP, leading to its activation
GMP synthase [glutamine-hydrolyzing] subunit A
Probable Brix domain-containing ribosomal biogenesis protein
Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
Probable glycine cleavage system H protein
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
3-phosphoshikimate 1-carboxyvinyltransferase
O-(3'-phospho-DNA)-tyrosine intermediate
DNA repair and recombination protein RadB
Digeranylgeranylglyceryl phosphate synthase
DNA polymerase II large subunit, 1st part
DNA polymerase II large subunit, 2nd part
DNA-directed RNA polymerase subunit Rpo11
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1
Cysteine sulfenic acid (-SOH) intermediate
Removed in mature form; by autocatalysis
Schiff-base intermediate with dihydroxyacetone-P
Decreases affinities for both ATP and pantoate.
Displays a defect in dimer assembly. Does not affect Km for ATP but the affinity for pantoate decreases dramatically.
Does not affect kinetics toward ATP but decreases affinity for pantoate.
Does not affect kinetics toward ATP but significantly decreases affinity for pantoate.
Greatly reduced enzymatic activity. Greatly reduced enzymatic activity; when associated with the deletion of the beta-jelly roll domain of the mature domain.
Loss of activity. Greatly destabilized; when associated with the deletion of the calcium-binding form of the beta-jelly roll domain of the mature domain.
HTH-type transcriptional regulator TrmBL2
Retains less than 3% of wild-type activity.
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NAD(P)H sulfur oxidoreductase (CoA-dependent)
Bifunctional IPC transferase and DIPP synthase
Probable cyclic pyranopterin monophosphate synthase
Probable molybdenum cofactor guanylyltransferase
Indolepyruvate oxidoreductase subunit IorB
Putative [LysW]-lysine/[LysW]-ornithine hydrolase
Fructose-1,6-bisphosphate aldolase/phosphatase
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
DNA repair and recombination protein RadA, 1st part
DNA repair and recombination protein RadA, 2nd part
Signal recognition particle 19 kDa protein
Adenosylcobinamide-GDP ribazoletransferase
Probable inosine/xanthosine triphosphatase
Translation initiation factor 2 subunit gamma
Signal recognition particle 54 kDa protein
5-methylthioadenosine/S-adenosylhomocysteine deaminase
Pyridoxal 5'-phosphate synthase subunit PdxS
Schiff-base intermediate with D-ribose 5-phosphate
Phosphoribosylformylglycinamidine cyclo-ligase
Molybdate/tungstate transport system permease protein WtpB
3-methyl-2-oxobutanoate hydroxymethyltransferase
Glyceraldehyde-3-phosphate dehydrogenase
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase
Tungsten-containing aldehyde ferredoxin oxidoreductase
Cyclic 2,3-diphosphoglycerate synthetase
N-(5'-phosphoribosyl)anthranilate isomerase
Imidazole glycerol phosphate synthase subunit HisF
Glutamyl-tRNA(Gln) amidotransferase subunit D
Translation initiation factor 2 subunit alpha
Nicotinamide-nucleotide adenylyltransferase
Uncharacterized serpin-like protein TK1782
Probable glycine dehydrogenase (decarboxylating) subunit 1
Probable glycine dehydrogenase (decarboxylating) subunit 2
Probable ribosomal RNA small subunit methyltransferase A
tRNA (pseudouridine(54)-N(1))-methyltransferase
Indolepyruvate oxidoreductase subunit IorA
Probable chemoreceptor glutamine deamidase CheD
Probable 6-oxopurine nucleoside phosphorylase
Molybdate/tungstate-binding protein WtpA
Polyribonucleotide 5'-hydroxyl-kinase TK1956
Putative HTH-type transcriptional regulatory protein TK0539
Gains the ability to form Asp-tRNA(Asn) in vitro, and is impaired in its ability to synthesize Asp-tRNA(Asp) due to a 8-fold decrease in affinity for tRNA(Asp).
Gains the ability to form Asp-tRNA(Asn) in vitro. Only 2-fold decrease in catalytic efficiency for Asp-tRNA(Asp) synthesis.
DNA double-strand break repair Rad50 ATPase
Ribosomal RNA small subunit methyltransferase Nep1
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
Schiff-base intermediate with acetaldehyde
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
Imidazole glycerol phosphate synthase subunit HisH
Putative transcriptional regulatory protein TK2151
Phosphate import ATP-binding protein PstB
Phosphoribosylformylglycinamidine synthase subunit PurQ
O-(5'-phospho-DNA)-tyrosine intermediate
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Methylated-DNA--protein-cysteine methyltransferase
DNA-directed RNA polymerase subunit Rpo5
Replication factor C small subunit, 1st part
Replication factor C small subunit, 2nd part
DNA-directed RNA polymerase subunit Rpo12
Pyruvoyl-dependent arginine decarboxylase subunit alpha
Pyruvoyl-dependent arginine decarboxylase subunit beta
GMP synthase [glutamine-hydrolyzing] subunit B
Formate-dependent phosphoribosylglycinamide formyltransferase
tRNA N6-adenosine threonylcarbamoyltransferase
UPF0173 metal-dependent hydrolase TK0141
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2
Decreases efficiency of the inhibition by CoA.
Decreases efficiency of the inhibition by CoA. Inhibition shows no time-dependency.
3-isopropylmalate dehydratase small subunit
Phenylalanine--tRNA ligase alpha subunit
tRNA (guanine(26)-N(2))-dimethyltransferase
ADP-dependent glucose/glucosamine kinase
Impairs molecular assembly. 60-fold decrease in catalytic activity.
Digeranylgeranylglycerophospholipid reductase
Forms homodimers. Shows almost wild-type activity.
Geranylgeranylglyceryl phosphate synthase
DNA-directed RNA polymerase subunit Rpo1C
Coenzyme A biosynthesis bifunctional protein CoaBC
Probable cobalamin biosynthesis protein CobD
3-isopropylmalate dehydratase large subunit
DNA-directed RNA polymerase subunit Rpo6
N(4)-bis(aminopropyl)spermidine synthase
DNA-directed RNA polymerase subunit Rpo10
Translation initiation factor 2 subunit beta
Phosphoribosylformylglycinamidine synthase subunit PurL
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Pyridoxal 5'-phosphate synthase subunit PdxT
Expected to impair oligomerization. Alters compaction of DNA on nucleosome-like structures. Delays adaptation to a sulfur-free medium due to impaired transcriptional activation of genes required for growth on a sulfur-free medium.
tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase
Pyruvate/ketoisovalerate oxidoreductases common subunit gamma
Protein-glutamate methylesterase/protein-glutamine glutaminase
Decrease in activity and in thermostability. Large decrease in activity; forms dimers; when associated with S-66 and S-69.
Large decrease in activity and in thermostability. Large decrease in activity; forms dimers; when associated with S-63 and S-69.
Slight decrease in activity; no change in thermostability. Large decrease in activity; forms dimers; when associated with S-63 and S-66.