Altered inheritance of mitochondria protein 36, mitochondrial
Temperature sensitive; impairs the transition from hyphal to yeast growth on rich yeast-inducing media.
Abolishes catalytic activity. Impairs biofilm and hyphal formation. Sensitive to thermal stress.
Abolishes catalytic activity. Mildly impairs biofilm and hyphal formation. Sensitive to thermal stress.
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
37S ribosomal protein S10, mitochondrial
Mediator of RNA polymerase II transcription subunit 10
RNA polymerase II holoenzyme cyclin-like subunit
Putative alpha-1,3-mannosyltransferase MNT4
Regulator of cytoskeleton and endocytosis RVS167
Impairs the heme transfer within the CFEM proteins cascade.
DNA replication complex GINS protein PSF1
Chromatin modification-related protein EAF1
General transcription and DNA repair factor IIH subunit TFB5
Mitochondrial inner membrane protease subunit
Mediator of RNA polymerase II transcription subunit 7
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Transcriptional regulator of yeast form adherence 3
Histone acetyltransferase type B subunit 2
Post-GPI attachment to proteins factor 3
GPI ethanolamine phosphate transferase 1
Ribosome-releasing factor 2, mitochondrial
GPI ethanolamine phosphate transferase 2
Mitochondrial import inner membrane translocase subunit TIM8
Cell wall integrity transcriptional regulator CAS5
Increased recombination centers protein 22-1
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Major facilitator superfamily multidrug transporter FLU1
Chromatin modification-related protein YNG2
Transcriptional regulator of filamentous growth FLO8
Oxysterol-binding protein-like protein OBPa
Chromatin modification-related protein EAF3
Cysteine sulfenic acid (-SOH) intermediate
Cell surface Cu-only superoxide dismutase 5
Mediator of RNA polymerase II transcription subunit 6
Mediator of RNA polymerase II transcription subunit 8
tRNA N6-adenosine threonylcarbamoyltransferase
Lung seven transmembrane receptor-domain-containing protein
Transcriptional regulator of yeast form adherence 5
Schiff-base intermediate with substrate; via topaquinone
5-glutamyl coenzyme A thioester intermediate
Mitochondrial homologous recombination protein 1
Vacuolar protein sorting-associated protein 27
Hyphal_reg_CWP domain-containing protein
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
General negative regulator of transcription subunit 3
Abolishes disulfide bonds; when associated with S-118.
Abolishes disulfide bonds; when associated with S-156.
Mitochondrial import inner membrane translocase subunit TIM22
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
Blocks phosphorylation of Ser-394 and Ser-395 and impairs hyphal morphogenesis.
Blocks phosphorylation of Ser-394 and impairs hyphal morphogenesis.
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Probable GPI-anchored adhesin-like protein PGA25
Probable GPI-anchored adhesin-like protein PGA55
Mitochondrial inner membrane magnesium transporter MRS2
Induced during hyphae development protein 1
Spindle assembly checkpoint component MAD2
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Major glycerophosphoinositol permease GIT3
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Putative alpha-1,3-mannosyltransferase MNN1
U3 small nucleolar RNA-associated protein 25
Rab guanine nucleotide exchange factor SEC2
Mitochondrial import inner membrane translocase subunit TIM50
Probable cytosolic iron-sulfur protein assembly protein 1
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Histone acetyltransferase type B catalytic subunit
Pheromone-processing carboxypeptidase KEX1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial
Eukaryotic translation initiation factor 6
Proton acceptor; for processing activity
Schiff-base intermediate with substrate; via pyruvic acid
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2-1
Dolichyl-phosphate-mannose--protein mannosyltransferase 5
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Multiple RNA-binding domain-containing protein 1
Putative alpha-1,3-mannosyltransferase MNN14
Cytosolic Fe-S cluster assembly factor CFD1
Proton donor; shared with dimeric partner
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase 2 alpha chain
Phosphatidylserine decarboxylase 2 beta chain
Phosphatidylserine decarboxylase proenzyme 2
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Conserved oligomeric Golgi complex subunit 6
In strain: ATCC 60193 / S-24; in allele 237 B.
Potential protein lysine methyltransferase SET5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Endo/exonuclease/phosphatase domain-containing protein
Interchain (with C-43 in GPX3); transient
Leads to constitutive nuclear localization.
Leads to hyper-activity and constitutive expression of MDR1.
Glycolipid 2-alpha-mannosyltransferase 2
Helical; Signal-anchor for type II membrane protein
Serine/threonine-protein phosphatase 2A activator 1
Cell surface superoxide dismutase [Cu-Zn] 4
Patatin-like phospholipase domain-containing protein CaO19.1504
In strain: fluconazole-resistant isolates.
Altered inheritance of mitochondria protein 21
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
CCCFC; essential for catalytic activity, may be the site of iron coordination
Eukaryotic translation initiation factor 3 subunit C
Cullin-associated NEDD8-dissociated protein 1
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
UDP-N-acetylglucosamine transferase subunit ALG13
Transcriptional regulator of yeast form adherence 2
Helical; Anchor for type IV membrane protein
Eukaryotic translation initiation factor 3 subunit I
ATP-dependent RNA helicase MRH4, mitochondrial
V-type proton ATPase catalytic subunit A
Abolishes catalytic activity; when associated with A-173 and A-248.
Abolishes catalytic activity; when associated with L-90 and A-173.
Abolishes catalytic activity; when associated with L-90 and A-248.
Serine/threonine-protein phosphatase PP2A-like PPG1
Mediator of RNA polymerase II transcription subunit 18
N-(5'-phosphoribosyl)anthranilate isomerase
Leads to constitutive MDR1 overexpression and multidrug resistance.
Phosphatidylethanolamine N-methyltransferase
Protein N-terminal and lysine N-methyltransferase EFM7
Mitochondrial distribution and morphology protein 10
Impairs filamentation and decreases virulence.
Leads to sensitivity to H(2)O(2) and t-butyl hydroperoxide and decreases virulence.
Oxidative stress response two-component system protein SSK1
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
Mediator of RNA polymerase II transcription subunit 21
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Glutathione peroxidase-like peroxiredoxin GPX3
Interchain (with C-446 in CAP1); transient
Exhibits a depolarized distribution of cortical actin patches, but allows hyphae formation.
Exhibits a depolarized distribution of cortical actin patches. Shows random budding pattern and is unable to form hyphae.
Decreases catalytic activity. Impairs catalytic activity; when associated with Ala-296 or Ser-330.
Decreases catalytic activity. Impairs catalytic activity; when associated with Ala-296.
Impairs catalytic activity; when associated with Ala-182.
Impairs catalytic activity; when associated with Ala-267.
Endoplasmic reticulum vesicle protein 25
Altered inheritance of mitochondria protein 11
Impairs BCR1 function during biofilm formation and virulence in a mouse model of disseminated candidiasis.
Iron-sulfur clusters transporter ATM1, mitochondrial
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Mediator of RNA polymerase II transcription subunit 11
Protein transport protein SEC61 subunit alpha
Cytochrome b-c1 complex subunit 2, mitochondrial
Chromatin modification-related protein EAF6
Mitochondrial thiamine pyrophosphate carrier 1
Impairs cell surface localization and localizes exclusively to internal ER-like structures.
Still allows localization to the cell surface.
Mitochondrial import inner membrane translocase subunit TIM9
Leads to temperature-sensitive (ts) conditional lethality.
3,4-dihydroxy-2-butanone 4-phosphate synthase
Increases Km for substrate 18-fold. Reduces activity by 30%.
Increases Km for substrate 4-fold. Reduces activity by 98%.
Loss of activity. Alters protein folding and stability.
Histone H3-like centromeric protein CSE4
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Cell-surface associated glycoprotein DFI1
Impairs CEK1 activation and invasive filamentation; when associated with L-273.
Impairs CEK1 activation and invasive filamentation; when associated with L-277.
Mitochondrial import inner membrane translocase subunit TIM14
Sensitive to high expression protein 9 homolog, mitochondrial
Adenylate kinase isoenzyme 6 homolog HBR1
PAN2-PAN3 deadenylation complex subunit PAN3
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
H/ACA ribonucleoprotein complex subunit CBF5
Cytochrome c oxidase assembly protein COX19
Mitochondrial inner membrane i-AAA protease complex subunit MGR1
Guanine nucleotide-binding protein subunit beta-like protein
Eukaryotic translation initiation factor 5A
ATPase synthesis protein 25, mitochondrial
Putative tyrosine-protein phosphatase OCA1
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Eukaryotic translation initiation factor 3 subunit A
Actin cytoskeleton-regulatory complex protein PAN1
Signal peptidase complex catalytic subunit SEC11
Schiff-base intermediate with D-ribose 5-phosphate
Cell surface superoxide dismutase [Cu-Zn] 6
Transcription and mRNA export factor SUS1
Mitochondrial outer membrane protein porin
Iron-regulated transcriptional activator AFT2
Cytochrome c oxidase-assembly factor COX23, mitochondrial
Histone transcription regulator 3 homolog
Impairs amyloid formation and decreases cell aggregation.
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)
FAD-binding FR-type domain-containing protein
ATP-dependent RNA helicase MSS116, mitochondrial
Structure-specific endonuclease subunit SLX4
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2-2
Causes temperature-dependent reduction in catalytic activity.
Glycylpeptide N-tetradecanoyltransferase
Increased recombination centers protein 22-2
Oxidant-induced cell-cycle arrest protein 5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
pH-response regulator protein palA/RIM20
Probable pathogenesis-related protein CaO19.2336
Eukaryotic translation initiation factor 4E
Transcription factor of morphogenesis MCM1
Mitochondrial inner membrane magnesium transporter LPE10
Adenylyltransferase and sulfurtransferase UBA4
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Mitochondrial genome maintenance protein MGM101
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Actin cytoskeleton-regulatory complex protein END3
Mitochondrial distribution and morphology protein 12
Morphogenetic regulator of filamentous growth protein 1
Altered inheritance of mitochondria protein 24, mitochondrial
Restriction of telomere capping protein 1
Mitochondrial intermembrane space import and assembly protein 40
Mitochondrial import inner membrane translocase subunit TIM21
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82
Serine hydroxymethyltransferase, cytosolic
Phosphatidylserine decarboxylase 1 alpha chain
Phosphatidylserine decarboxylase 1 beta chain
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
Mitochondrial group I intron splicing factor CCM1
Antagonist of mitotic exit network protein 1
UTP--glucose-1-phosphate uridylyltransferase
Proton acceptor; for 3-dehydroquinate synthase activity
Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity
Major facilitator superfamily multidrug transporter NAG4
Probable GPI-anchored adhesin-like protein PGA32
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
EMC7_beta-sandw domain-containing protein
Impairs chlamydospore formation and hypha formation.
Impairs chlamydospore formation but causes hyperfilamentation.
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Mediator of RNA polymerase II transcription subunit 16
Mitochondrial distribution and morphology protein 34
Clathrin-associated protein AP-3 complex component APS3
Mitochondrial zinc maintenance protein 1, mitochondrial
Transcription initiation factor TFIID subunit 4
cAMP-dependent protein kinase regulatory subunit
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2
Meiotic sister chromatid recombination protein 1
Initiation-specific alpha-1,6-mannosyltransferase
Methylated-DNA--protein-cysteine methyltransferase
Altered inheritance of mitochondria protein 9, mitochondrial
Mediator of RNA polymerase II transcription subunit 31
5-aminolevulinate synthase, mitochondrial
ATP-dependent RNA helicase SUV3, mitochondrial
Vacuolar protein sorting-associated protein 4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
Leads to increased ERG11 expression, increased cellular ergosterol, and decreased susceptibility to fluconazole.
Mitochondrial import inner membrane translocase subunit TIM54
AdoMet-dependent rRNA methyltransferase SPB1
Putative alpha-1,3-mannosyltransferase MNN12
ISWI chromatin-remodeling complex ATPase ISW2
DNA replication complex GINS protein PSF2
Polyadenylate-binding protein, cytoplasmic and nuclear
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ubiquitin-like modifier-activating enzyme ATG7
Dual specificity protein tyrosine phosphatase CCP1
54S ribosomal protein L51, mitochondrial
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Probable sucrose utilization protein SUC1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
DNA-directed RNA polymerase III subunit RPC3
Eukaryotic translation initiation factor 3 subunit J
Respiratory supercomplex factor 1, mitochondrial
Carbamoyl-phosphate synthase arginine-specific small chain
Amino-acid acetyltransferase, mitochondrial
Deoxyuridine 5'-triphosphate nucleotidohydrolase
U3 small nucleolar RNA-associated protein 10
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Major facilitator superfamily multidrug transporter NAG3
Tethering factor for nuclear proteasome STS1
Vacuolar protein sorting-associated protein 62
Defective in cullin neddylation protein 1
NADPH-dependent diflavin oxidoreductase 1
pH-response regulator protein palH/RIM21
Phosphatidylinositol transfer protein SFH5
Vacuolar protein-sorting-associated protein 46
Chromatin modification-related protein EAF7
Translationally-controlled tumor protein homolog
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Endosomal/vacuolar adapter protein YPT35
In CEM-1; dominant active allele that allows filamentation, activates alkaline-expressed and represses acid-expressed genes at acidic pH.
In CEM-2; dominant active allele that allows filamentation, activates alkaline-expressed and represses acid-expressed genes at acidic pH.
In RIM101-405; is active independent on proteolytic processing. Allows filamentation at alkaline pH in the absence of RIM13 or RIM8 and RIM20.
pH-response transcription factor pacC/RIM101
Maintenance of mitochondrial morphology protein 1
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Cation_ATPase_C domain-containing protein
Probable GPI-anchored adhesin-like protein PGA18
Presequence translocated-associated motor subunit PAM17, mitochondrial
U1 small nuclear ribonucleoprotein component SNU71
Cytosolic Fe-S cluster assembly factor NAR1
Probable pathogenesis-related protein CaO19.6200
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
JmjC domain-containing histone demethylation protein 1
Spindle assembly checkpoint component MAD1
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Eukaryotic translation initiation factor 3 subunit G
Phosphatidylglycerol/phosphatidylinositol transfer protein
Decreases thermotolerance; when associated with A-570, A-556 and A-577.
Decreases thermotolerance; when associated with A-570, A-574 and A-576.
Decreases thermotolerance; when associated with A-570, A-576 and A-577.
Decreases thermotolerance; when associated with A-574, A-576 and A-577.
Mimics phosphorylation and increases thermotolerance; when associated with E-570, E-556 and E-577.
Mimics phosphorylation and increases thermotolerance; when associated with E-570, E-574 and E-576.
Mimics phosphorylation and increases thermotolerance; when associated with E-570, E-576 and E-577.
Mimics phosphorylation and increases thermotolerance; when associated with E-574, E-576 and E-577.
Cytochrome c oxidase assembly protein COX16, mitochondrial
Fork-head transcriptional regulator FHL1
Increased recombination centers protein 6
Mitochondrial inner membrane protease ATP23
Mitochondrial import inner membrane translocase subunit TIM13
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-148 in ATG5)
Mediator of RNA polymerase II transcription subunit 14
Regulator of cytoskeleton and endocytosis RVS161
Transcriptional regulator of yeast form adherence 4
Chitobiosyldiphosphodolichol beta-mannosyltransferase
Class E vacuolar protein-sorting machinery protein HSE1
Mediator of RNA polymerase II transcription subunit 4
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Serine/threonine-protein phosphatase SIT4
Glycolipid 2-alpha-mannosyltransferase 1
Succinate dehydrogenase assembly factor 3, mitochondrial
DNA replication complex GINS protein PSF3
Glycerophosphocholine phosphodiesterase GDE1
Mediator of RNA polymerase II transcription subunit 13
Postreplication repair E3 ubiquitin-protein ligase RAD18
Coupling of ubiquitin conjugation to ER degradation protein 1
mRNA cleavage and polyadenylation factor CLP1
Dolichyl-phosphate-mannose--protein mannosyltransferase 6
Ferric/cupric reductase transmembrane component 1
22% of the catalytic activity of the wild-type.
26% of the catalytic activity of the wild-type.
38% of the catalytic activity of the wild-type.
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Less than 5% of the catalytic activity of the wild-type.
No effect on catalytic activity; when associated with A-103 and A-104, or with T-103 and T-104, or with Y-103 and Y-104.
No effect on catalytic activity; when associated with A-103 and A-107, or with T-103 and T-107, or with Y-103 and Y-107.
No effect on catalytic activity; when associated with A-104 and A-107, or with T-104 and T-107, or with Y-104 and Y-107.
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Eukaryotic translation initiation factor 3 subunit B
Transcriptional regulator of yeast form adherence 6
Maintenance of telomere capping protein 6
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
37S ribosomal protein S25, mitochondrial
Nascent polypeptide-associated complex subunit alpha
UDP-N-acetylglucosamine transferase subunit ALG14
Putative alpha-1,3-mannosyltransferase MNN13
Vacuolar membrane-associated protein IML1
Serine/threonine-protein kinase STE7 homolog
Genetic interactor of prohibitins 3, mitochondrial
Putative transferase CAF17, mitochondrial
Glycosylphosphatidylinositol anchor biosynthesis protein 11
Dihydroorotate dehydrogenase (quinone), mitochondrial
60S ribosomal subunit assembly/export protein LOC1
Mediator of RNA polymerase II transcription subunit 17
Ubiquinone biosynthesis protein COQ4, mitochondrial
Actin cytoskeleton-regulatory complex protein SLA1
Nascent polypeptide-associated complex subunit beta
Transcription factor IIIB 70 kDa subunit
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Methylthioribulose-1-phosphate dehydratase
Chromosome segregation in meiosis protein 3
Leads to mislocalization and general drug-sensitivity.
Leads to reduced drug efflux and ATPase activity.
Leads to reduced drug efflux but shows normal ATPase activity.
Pleiotropic ABC efflux transporter of multiple drugs CDR1
Phosphatidylethanolamine amidated glycine
Multiple drug resistance-associated protein-like transporter 1
13 kDa ribonucleoprotein-associated protein
Probable GPI-anchored adhesin-like protein PGA28
Hypha-specific G1 cyclin-related protein 1
In MPA-resistant strain; decreases the K(M) values for both substrates. Decreases sensitivity to MPA 4-fold, but increases sensitivity to mizoribine monophosphate 40-fold.
Oligosaccharide translocation protein RFT1
Phosphoribosylaminoimidazole carboxylase
Serine/threonine-protein phosphatase 2A activator 2
Altered inheritance of mitochondria protein 23, mitochondrial
FAS1 domain-containing protein CaO19.3004
Mediator of RNA polymerase II transcription subunit 22
3-ketodihydrosphingosine reductase TSC10
Putative NADPH-dependent methylglyoxal reductase GRP2
Cell division control protein 42 homolog
Dolichyl-phosphate-mannose--protein mannosyltransferase 4
Translation initiation factor eIF-2B subunit epsilon
Mitochondrial import inner membrane translocase subunit TIM16
Putative alpha-1,3-mannosyltransferase MNN15
Probable GPI-anchored adhesin-like protein PGA22