Charge relay system; for serine protease NS3 activity
Complete loss of 2'-O-methyltransferase activity. No effect on N-7 methyltransferase activity.
ER anchor for the capsid protein C, removed in mature form by serine protease NS3
Lethal for the virus. Complete loss of 2'-O and N-7 methyltransferase activities.
Loss of interaction between capsid protein C and host EXOC1.
N-linked (GlcNAc...) asparagine; by host