FERM, ARHGEF and pleckstrin domain-containing protein 1
Sigma non-opioid intracellular receptor 1
Dimethylaniline monooxygenase [N-oxide-forming] 2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
General transcription factor IIH subunit 3
Zinc finger and BTB domain-containing protein 42
Low affinity immunoglobulin gamma Fc region receptor III-A
Nuclear distribution protein nudE homolog 1
S-palmitoyl cysteine; by ZDHHC2, ZDHHC3 and ZDHHC7
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)
Intraflagellar transport protein 80 homolog
Aryl hydrocarbon receptor nuclear translocator
Helical; Signal-anchor for type II membrane protein
Regulator of microtubule dynamics protein 1
Interchain (between alpha and beta chains)
Saccharopine dehydrogenase-like oxidoreductase
G protein-activated inward rectifier potassium channel 3
UV excision repair protein RAD23 homolog B
39S ribosomal protein L16, mitochondrial
Guanine nucleotide-binding protein subunit beta-4
Lysosome-associated membrane glycoprotein 1
Lowers activity 3000-fold. Lowers activity 70000-fold; when associated with A-142.
Lowers activity 40000-fold. Lowers activity 70000-fold; when associated with A-217.
Copper chaperone for superoxide dismutase
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Transcription initiation factor IIA alpha chain
Transcription initiation factor IIA beta chain
Transcription initiation factor IIA subunit 1
Calcium/calmodulin-dependent protein kinase type II subunit beta
Cocaine- and amphetamine-regulated transcript protein
GDP-fucose protein O-fucosyltransferase 2
Protein arginine methyltransferase NDUFAF7, mitochondrial
Eukaryotic peptide chain release factor subunit 1
NIKS motif; plays an important role in translational termination
O-linked (Xyl...) (heparan sulfate) serine
Processed sterol regulatory element-binding protein 2
Sterol regulatory element-binding protein 2
Transcription elongation factor A protein 2
Beta-galactoside alpha-2,6-sialyltransferase 1
Loss of catalytic activity; when associated with A-350.
Loss of catalytic activity; when associated with A-361.
Loss of sialyltransferase activity and aberrant subcellular location.
No effect on protein stability, nor on catalytic activity.
Reduced KM/kcat values for CMP-Neu5Ac, no effect on kinetic constants for beta-Gal1,4-GlcNAc.
Small decrease of sialyltransferase activity.
DNA damage-inducible transcript 4 protein
Mitochondrial import inner membrane translocase subunit Tim10
O-linked (Gal...) hydroxylysine; alternate
5'-AMP-activated protein kinase catalytic subunit alpha-2
Cyclic AMP-dependent transcription factor ATF-6 alpha
Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
No effect on activation by PKA. Abolishes activation by PKA; when associated with A-959.
Slightly decreases activation by PKA. Abolishes activation by PKA; when associated with A-960.
Sperm mitochondrial-associated cysteine-rich protein
Pituitary tumor-transforming gene 1 protein-interacting protein
Polypeptide N-acetylgalactosaminyltransferase 11
General transcription factor IIH subunit 2
Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCE
Signal transducer and activator of transcription 3
Heterogeneous nuclear ribonucleoprotein U
Eukaryotic translation initiation factor 3 subunit A
Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)
Sodium channel protein type 1 subunit alpha
Gamma-aminobutyric acid receptor subunit alpha-5
Interchain (between heavy and light chains)
Thioredoxin domain-containing protein 15
Cytochrome b-c1 complex subunit 6, mitochondrial
Low affinity immunoglobulin gamma Fc region receptor III
KH domain-containing, RNA-binding, signal transduction-associated protein 3
Phosphofurin acidic cluster sorting protein 1
TYRO protein tyrosine kinase-binding protein
Beta-1,4 N-acetylgalactosaminyltransferase 1
Interleukin-1 receptor accessory protein-like 1
Helical; Signal-anchor for type III membrane protein
5-glutamyl coenzyme A thioester intermediate
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Solute carrier organic anion transporter family member 1A4
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)
Selenocysteine insertion sequence-binding protein 2
Calcium-responsive transcription coactivator
N-acetylalanine; in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
cAMP-dependent protein kinase type I-alpha regulatory subunit
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
Interchain (between non-catalytic and catalytic chains)
Transmembrane protease serine 11D catalytic chain
Transmembrane protease serine 11D non-catalytic chain
Gamma-aminobutyric acid receptor subunit alpha-1
Strongly decreases the affinity for GABA-dependent channel gating.
Dehydrogenase/reductase SDR family member 6
Abolished dopaminylation by TGM2. Impaired regulation of relapse-related transcriptional plasticity in the reward system.
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
N6-(2-hydroxyisobutyryl)lysine; alternate
N6-(beta-hydroxybutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Symmetric dimethylarginine; by PRMT5; alternate
Trimethyllysine dioxygenase, mitochondrial
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
N6,N6,N6-trimethyllysine; by METTL21A; in vitro
NAD-dependent protein deacetylase sirtuin-2
Reduced deacetylase activity on alpha-tubulin and stimulates oligodendrocyte precursor (OLP) differentiation.
Reduced deacetylase activity on alpha-tubulin.
Phosphotyrosine; by autocatalysis, CSK and MATK
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Strongly decreased affinity for squalene.
Gamma-aminobutyric acid receptor subunit alpha-2
ATP-dependent RNA helicase SUPV3L1, mitochondrial
Glutamate receptor ionotropic, kainate 4
Zinc finger FYVE domain-containing protein 26
Reduces phosphatase activity towards PtdIns(4)P, but not towards PtdIns(3)P or PtdIns(3,5)P2.
Mas-related G-protein coupled receptor member B4
Dehydrogenase/reductase SDR family member 9
Low-density lipoprotein receptor-related protein 3
Pentatricopeptide repeat-containing protein 1, mitochondrial
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor protein)
Meiosis-specific with OB domain-containing protein
Calcium/calmodulin-dependent protein kinase type II subunit delta
In isoform Delta 5, isoform Delta 6 and isoform Delta 7.
Schiff-base intermediate with substrate; via topaquinone
Flagellum-associated coiled-coil domain-containing protein 1
Ubiquitin carboxyl-terminal hydrolase 21
Abolishes most of enzyme activity and dimer formation. No enzyme activity nor dimer formation; when associated with D-143.
Abolishes most of enzyme activity and dimer formation. No enzyme activity nor dimer formation; when associated with E-137.
Broader pH maximum levels around 5.4 but no change in specific activity. Lower pH maximum around 4.5 and more sensitive to L(+)tartrate inhibition but no change in specific activity; when associated with K-154.
PH optimum at 5.4 as for wild type and no change in specific activity. Lower pH maximum around 4.5 and more sensitive to L(+)tartrate inhibition but no change in specific activity; when associated with G-158.
Translation initiation factor eIF-2B subunit epsilon
Natural resistance-associated macrophage protein 1
Microphthalmia-associated transcription factor
Tyrosine-protein phosphatase non-receptor type 2
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Isovaleryl-CoA dehydrogenase, mitochondrial
Promotes sensitivity to myricetin inhibitor.
reversibly protonated residue during proton transport
Proto-oncogene tyrosine-protein kinase Src
Carnitine O-palmitoyltransferase 1, muscle isoform
N-terminal Xaa-Pro-Lys N-methyltransferase 2
Killer cell lectin-like receptor subfamily B member 1A
ATP-binding cassette sub-family A member 7
Cytochrome c oxidase subunit 8C, mitochondrial
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASK
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Ribonucleoside-diphosphate reductase subunit M2
Omega-N-methylarginine; by CARM1; alternate
SPRY domain-containing SOCS box protein 3
Zinc finger CCHC domain-containing protein 2
Guanylate cyclase soluble subunit beta-2
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Long-chain-fatty-acid--CoA ligase ACSBG1
Soluble calcium-activated nucleotidase 1
Calcium-transporting ATPase type 2C member 2
Mesencephalic astrocyte-derived neurotrophic factor
Schiff-base intermediate with dihydroxyacetone-P
Calcium/calmodulin-dependent protein kinase kinase 2
Guanine nucleotide exchange factor C9orf72 homolog
Coiled-coil domain-containing protein 60
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
LysM and putative peptidoglycan-binding domain-containing protein 1
C-Jun-amino-terminal kinase-interacting protein 1
Phosphothreonine; by MAPK8, MAPK9 and MAPK10
MAP kinase-activating death domain protein
Vacuolar protein sorting-associated protein 4A
Transient receptor potential cation channel subfamily M member 4
Amyloid-beta A4 precursor protein-binding family A member 1
Enhanced APP binding and amyloid-beta production.
Histone-arginine methyltransferase CARM1
Ankyrin repeat and SAM domain-containing protein 6
Decreased NEK8-binding, but no effect on INVS-binding; when associated with A-129.
Decreased NEK8-binding, but no effect on INVS-binding; when associated with A-209.
In cy; loss of ability to self-associate, does not affect interaction with Bicc1; loss of interaction with ANKS3.
No effect on interaction with INVS, NEK8 AND NPHP3, nor on ciliary localization. Unable to rescue ANKS6 knockout in a heterologous system.
Presenilins-associated rhomboid-like protein, mitochondrial
Actin, cytoplasmic 2, N-terminally processed
N-acetylglutamate; in Actin, cytoplasmic 2, N-terminally processed
Phosphothreonine; by ROCK1, ROCK2, CDC42BP, ZIPK/DAPK3 and RAF1
Protein phosphatase 1 regulatory subunit 12A
Eukaryotic translation initiation factor 3 subunit E
Ectonucleoside triphosphate diphosphohydrolase 2
Interleukin-1 receptor antagonist protein
Nuclear receptor subfamily 1 group D member 2
Regenerating islet-derived protein 3-gamma 15 kDa form
Regenerating islet-derived protein 3-gamma 16.5 kDa form
Mimicks the GTP-bound state and is enriched in the Golgi region.
Decreased elongase activity toward (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA.
Elongation of very long chain fatty acids protein 2
Loss of elongase activity toward (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA.
Helical; Anchor for type IV membrane protein
Breast cancer type 1 susceptibility protein homolog
Killer cell immunoglobulin-like receptor 3DL1
Probable methyltransferase-like protein 24
Killer cell lectin-like receptor subfamily I member 2
N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1
Leucine-rich repeat-containing protein 57
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Double-stranded RNA-specific adenosine deaminase
Spermatid-specific linker histone H1-like protein
DXXLL motif involved in the interaction with GGA1
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1
LHFPL tetraspan subfamily member 6 protein
POU domain, class 2, transcription factor 3
Receptor-type tyrosine-protein phosphatase V
Guanine nucleotide-binding protein subunit alpha-15
Tyrosine-protein phosphatase non-receptor type 21
N-acetylglucosamine-6-phosphate deacetylase
Homeodomain-interacting protein kinase 4
Neutrophil immunoglobulin-like receptor 1
Phosphothreonine; by PKB/AKT1 or PKB/AKT2 and SGK1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Adaptin ear-binding coat-associated protein 2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
FXYD domain-containing ion transport regulator
Cyclic AMP-dependent transcription factor ATF-3
Cytosolic carboxypeptidase-like protein 5
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-526; A-528 and A-531.
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-526; A-528 and A-533.
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-526; A-531 and A-533.
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-528; A-531 and A-533.
Caspase recruitment domain-containing protein 9
Secreted lymphocyte activation gene 3 protein
No effect; when associated with Q-218 and Q-285.
No effect; when associated with Q-281 and Q-283.
No effect; when associated with Q-283 and Q-285.
No effect; when associated with Q-557 and Q-558.
No effect; when associated with Q-557 and Q-559.
No effect; when associated with Q-558 and Q-559.
Shifts the voltage-sensitivity to more negative values.
Shifts the voltage-sensitivity to more negative values; when associated with Q-233 and Q-235.
Shifts the voltage-sensitivity to more negative values; when associated with Q-233 and Q-236.
Shifts the voltage-sensitivity to more negative values; when associated with Q-235 and Q-236.
Shifts the voltage-sensitivity to more positive values.
Shifts the voltage-sensitivity to slightly more positive values.
Shifts the voltage-sensitivity to slightly more positive values; when associated with Q-571 and Q-572.
Shifts the voltage-sensitivity to slightly more positive values; when associated with Q-571 and Q-577.
Shifts the voltage-sensitivity to slightly more positive values; when associated with Q-572 and Q-577.
O-linked (Xyl...) (glycosaminoglycan) serine
ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 4; required for efficient microtubule binding and stabilization
Rho guanine nucleotide exchange factor 37
Lipid droplet-regulating VLDL assembly factor AUP1
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Chymotrypsin-like elastase family member 2A
Tubulin polymerization-promoting protein family member 3
Helical; Voltage-sensor; Name=Segment S4
Potassium voltage-gated channel subfamily H member 5
Endothelial differentiation-related factor 1
Cyclic nucleotide-gated olfactory channel
Bifunctional purine biosynthesis protein ATIC
Proton acceptor; for AICAR formyltransferase activity
Proton donor/acceptor; for FAICAR cyclization activity
O-linked (Xyl...) (chondroitin sulfate) serine; alternate
O-linked (Xyl...) (heparan sulfate) serine; alternate
Mitochondrial tRNA-specific 2-thiouridylase 1
Ferritin heavy chain, N-terminally processed
N-acetylthreonine; in Ferritin heavy chain, N-terminally processed
Megakaryocyte-associated tyrosine-protein kinase
Mini-chromosome maintenance complex-binding protein
Intraflagellar transport protein 22 homolog
ATP-binding cassette sub-family C member 3
Dimethyladenosine transferase 2, mitochondrial
FAST kinase domain-containing protein 2, mitochondrial
snRNA-activating protein complex subunit 2
Reduces interaction with ARRB2; when associated with I-387 and I-389.
Reduces interaction with ARRB2; when associated with I-387 and N-394.
Reduces interaction with ARRB2; when associated with I-389 and N-394.
Transcription termination factor 4, mitochondrial
Asymmetric dimethylarginine; by PRMT1; alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate
Omega-N-methylarginine; by PRMT1; alternate
Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3
T-cell activation inhibitor, mitochondrial
Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial
Zinc finger TRAF-type-containing protein 1
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
Methylated-DNA--protein-cysteine methyltransferase
Arginine/serine-rich coiled-coil protein 2
Proto-oncogene tyrosine-protein kinase ROS
Gamma-aminobutyric acid type B receptor subunit 1
In isoform 1A, isoform 1B and isoform 1D.
In isoform 1B, isoform 1C and isoform 1D.
Mas-related G-protein coupled receptor member X1
Inactive pancreatic lipase-related protein 1
In 3Y1tsD123 cell line; reversibly arrested in G1 phase of cell cycle at the restrictive temperature of 39.8 degrees Celsius; due to extensive degradation by the proteasome.
Mitochondrial import inner membrane translocase subunit TIM44
Growth hormone-inducible transmembrane protein
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
Sodium/potassium-transporting ATPase subunit beta-1
Constitutively active. Interacts with PPP5C, activates its phosphatase activity and translocates PPP5C to the plasma membrane.
Guanine nucleotide-binding protein subunit alpha-12
Hydroxymethylglutaryl-CoA synthase, mitochondrial
O-linked (Xyl...) (chondroitin sulfate) serine
Gamma-aminobutyric acid receptor-associated protein-like 1
Phosphatidylethanolamine amidated glycine; alternate
Phosphatidylserine amidated glycine; alternate
Leucine-rich repeat-containing protein 4
Mothers against decapentaplegic homolog 2
Pleckstrin homology domain-containing family B member 1
Multiple epidermal growth factor-like domains protein 6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
O-linked (Xyl...) (keratan sulfate) threonine
Differentially expressed in FDCP 8 homolog
Neurogenic locus notch homolog protein 3
Platelet-derived growth factor subunit B
Phosphoserine; by GSK3-alpha and GSK3-beta
DNA-directed RNA polymerase II subunit GRINL1A
Confers inhibition of transferrin uptake comparable to Sh3gl3 upon overexpression.
Tyrosine-protein phosphatase non-receptor type 5
Biogenesis of lysosome-related organelles complex 1 subunit 1
Gamma-aminobutyric acid receptor subunit delta
Alters selectivity of the channel for sodium. No effect on channel function.
Loss of regulation by PKC through PRKCABP; when associated with G-40.
Loss of regulation by PKC through PRKCABP; when associated with G-523.
No effect on selectivity or channel function.
Loss of epoxide hydrolase activity; when associated with Y-517.
Reduces epoxide hydrolase activity by 50%. Loss of activity; when associated with Y-521.
Reduces epoxide hydrolase activity by 80%; when associated with H-526.
Reduces epoxide hydrolase activity by 80%; when associated with T-542.
Reduces epoxide hydrolase activity by 95%.
S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine
Slight loss of epoxide hydrolase activity.
Slight reduction of epoxide hydrolase activity.
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Reduced RNA editing activity; when associated with A-128.
Reduced RNA editing activity; when associated with A-281.
Store-operated calcium entry regulator STIMATE
Adenosine deaminase domain-containing protein 1
Guided entry of tail-anchored proteins factor 1
Failed to protect against extrinsic and intrinsic apoptotic pathways; when associated with F-31. Not interferes with DISC assembly; when associated with F-31. Promotes BAX activation; when associated with F-31.
Failed to protect against extrinsic and intrinsic apoptotic pathways; when associated with R-69. Not interferes with death-inducing signaling complex (DISC) assembly; when associated with R-69. Promotes BAX activation; when associated with R-69.
Not phosphorylated by CK2. Loses the ability to block CASP8-, FAS-, or TNFRSF1A-induced apoptosis. Prevents translocation to mitochondria. Significantly decreases resistance to hydrogen peroxide-induced cell death. Doesn't interact with PPM1G, BAX and CASP2. Doesn't inhibit CASP2 and CASP3 activation. Doesn't was inhibit CASP8-induced apoptosis.
Significantly enhances resistance against hydrogen peroxide- and induced by isoproterenol or aldosterone-induced cell death.
ATP-binding cassette sub-family D member 3
Inhibition of palmitic acid beta-oxidation.
S-adenosylhomocysteine hydrolase-like protein 1
Alpha-ketoglutarate-dependent dioxygenase FTO
NAD(P)(+)--arginine ADP-ribosyltransferase
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Inactive ubiquitin carboxyl-terminal hydrolase 54
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Electron transfer flavoprotein beta subunit lysine methyltransferase
Leucine-rich repeat-containing protein 3
Has negligible effect on ATPase activity.
Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCD
Ubiquitin recognition factor in ER-associated degradation protein 1
cGMP-dependent 3',5'-cyclic phosphodiesterase
Arginine-glutamic acid dipeptide repeats protein
T-cell surface glycoprotein CD3 gamma chain
Lysophosphatidylcholine acyltransferase 1
Coiled-coil domain-containing protein 32
'Ionic lock' involved in activated form stabilization
Heart- and neural crest derivatives-expressed protein 2
Abolishes phosphatidylinositol-3-phosphate-binding and impairs subcellular location.
N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed
SKI8 subunit of superkiller complex protein
SKI8 subunit of superkiller complex protein, N-terminally processed
Loss of NCOA2-binding; when associated with S-385.
Loss of NCOA2-binding; when associated with S-388.
Loss of enhancement of AR and NR3C1-dependent transactivation; no effect on interaction with AR and NR3C1; when associated with A-23.
Loss of enhancement of AR and NR3C1-dependent transactivation; no effect on interaction with AR and NR3C1; when associated with A-305.
Loss of promotion of JUN sumoylation; no loss of interaction with SUMO1 and UBE2I.
No effect on auto-sumoylation; when associated with R-324.
No effect on auto-sumoylation; when associated with R-326.
No effect on auto-sumoylation; when associated with R-379.
No effect on auto-sumoylation; when associated with R-380.
No effect on auto-sumoylation; when associated with R-390.
No effect on auto-sumoylation; when associated with R-391.
No effect on auto-sumoylation; when associated with R-430.
No effect on auto-sumoylation; when associated with R-431.
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Platelet-derived growth factor subunit A
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
U3 small nucleolar ribonucleoprotein protein IMP4
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Cleavage and polyadenylation specificity factor subunit 4
Glycine amidinotransferase, mitochondrial
Atrial natriuretic peptide-converting enzyme
Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment
Atrial natriuretic peptide-converting enzyme, N-terminal propeptide
Atrial natriuretic peptide-converting enzyme, activated protease fragment
Impairs proteolytic processing and activation.
Interchain (between N-terminal propeptide and activated protease fragment chains)
Prevents proteolytic processing and activation; when associated with S-1087.
Prevents proteolytic processing and activation; when associated with S-968.
Gamma-aminobutyric acid receptor subunit alpha-4
3-phosphoinositide-dependent protein kinase 1
Hyaluronan-binding protein 2 27 kDa light chain
Hyaluronan-binding protein 2 27 kDa light chain alternate form
Hyaluronan-binding protein 2 50 kDa heavy chain
Hyaluronan-binding protein 2 50 kDa heavy chain alternate form
Abolishes autocleavage; when associated with I-151.
Abolishes autocleavage; when associated with V-152.
No effect; when associated with E-151 or N-151.
Proprotein convertase subtilisin/kexin type 9
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Lactosylceramide 4-alpha-galactosyltransferase
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
In Sprague-Dawley males; could be unrelated to gender.
Proton acceptor; for azaheterocycle hydroxylase activity
Pro-neuregulin-2, membrane-bound isoform
Complete loss of inhibition of the CHRNA9-CHRNA10 receptor by the alpha-conotoxin RgIA.
Neuronal acetylcholine receptor subunit alpha-9
No significant change in potency of inhibition of the CHRNA9-CHRNA10 receptor by the alpha-conotoxin RgIA.
No significant change in potency of inhibition of the CHRNA9-CHRNA10 receptorby the alpha-conotoxin RgIA.
The CHRNA9-CHRNA10 receptor is 1700-fold less potently inhibited by the alpha-conotoxin RgIA.
The CHRNA9-CHRNA10 receptor is 20-fold less potently inhibited by the alpha-conotoxin RgIA.
The CHRNA9-CHRNA10 receptor is 8.5-fold less potently inhibited by the alpha-conotoxin RgIA.
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Voltage-dependent calcium channel gamma-4 subunit
Aspartate 1-(chondroitin 4-sulfate)-ester
Inter-alpha-trypsin inhibitor heavy chain H3
Testis, prostate and placenta-expressed protein
Megakaryocyte and platelet inhibitory receptor G6b
Abolishes phosphorylation by PKA; when associated with A-446.
Abolishes phosphorylation by PKA; when associated with C-443.
In ADMS: Dominant negative mutation that abolishes channel activity; leads to myokymia, neuromyotonia, spontaneous epileptic seizures and premature death.
Is blocked by the scorpion mesomartoxin, with an IC(50)=16.60 nM.
Is not blocked by the scorpion mesomartoxin.
Potassium voltage-gated channel subfamily A member 1
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
Moderately decreased thioesterase activity.
S-acyl fatty acid synthase thioesterase, medium chain
Strongly decreased thioesterase activity with FASN-bound fatty acids. No effect on thioesterase activity with free decanoyl coenzyme A.
Markedly reduced phosphorylation, 70% loss of CNP-dependent activity.
Markedly reduced phosphorylation, 80% loss of CNP-dependent activity.
No effect on phosphorylation, 30% loss of CNP-dependent activity.
Reduced phosphorylation, 30% loss of CNP-dependent activity.
Reduced phosphorylation, 50% loss of CNP-dependent activity.
Transmembrane emp24 domain-containing protein 3
Mitochondrial basic amino acids transporter
RNA polymerase II-associated factor 1 homolog
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Transmembrane protease serine 11G catalytic chain
Transmembrane protease serine 11G non-catalytic chain
Cilia- and flagella-associated protein 300
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Nuclear receptor subfamily 4 group A member 3
ATPase activity reduced by 60%-70%. ATPase activity reduced by 92%; when associated with Q-193.
ATPase activity reduced by 60%-70%. ATPase activity reduced by 92%; when associated with T-139.
Outer mitochondrial transmembrane helix translocase
Mothers against decapentaplegic homolog 4
LHFPL tetraspan subfamily member 5 protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Abolishes the inhibition of PDGF-mediated ERK1/ERK2 phosphorylation. Inhibits interaction with HRAS and does not colocalize with active GTP-bound form of HRAS at membranes. Does not inhibit interaction with BRAF or RAF1.
Does not increase the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1. Inhibits phosphorylation; when associated with A-258.
Does not inhibit interaction and colocalization with active GTP-bound form of HRAS at membranes. Does not inhibit interaction with BRAF or RAF1.
Increases the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1.
Inhibits phosphorylation; when associated with A-494.
ATP synthase F(0) complex subunit B1, mitochondrial
Dual specificity mitogen-activated protein kinase kinase 5
Calcium-binding and coiled-coil domain-containing protein 1
PxLPxI/L motif; mediates interaction with ANKRA2
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
39S ribosomal protein L17, mitochondrial
Cytoplasmic polyadenylation element-binding protein 1
Gamma-aminobutyric acid receptor-associated protein-like 2
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Cell growth-regulating nucleolar protein
Suppressor of tumorigenicity 7 protein-like
Normal mucosa of esophagus-specific gene 1 protein
Alpha-aminoadipic semialdehyde synthase, mitochondrial
Amiloride-sensitive sodium channel subunit gamma
Interferes with ubiquitination and increases amiloride-sensitive current and the number of active channels; when associated with R-13.
Interferes with ubiquitination and increases amiloride-sensitive current and the number of active channels; when associated with R-6.
Ubiquinol-cytochrome-c reductase complex assembly factor 2
Microtubule-associated protein RP/EB family member 1
Abolishes expression at the cell membrane. Abolishes lactate transport across the cell membrane without affecting expression at the cell membrane; when associated with E-306.
Abolishes expression at the cell membrane. Abolishes lactate transport across the cell membrane without affecting expression at the cell membrane; when associated with R-302.
No effect on expression at the cell membrane, but abolishes lactate transport across the cell membrane.
No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane.
4-hydroxyphenylpyruvate dioxygenase-like protein
Translation initiation factor eIF-2B subunit gamma
Loss of kinase activity and activation by autophosphorylation; when associated with T-1381.
Loss of kinase activity and activation by autophosphorylation; when associated with T-1393.
Loss of kinase activity and of autophosphorylation activity.
Mitogen-activated protein kinase kinase kinase 1
non-specific serine/threonine protein kinase
Histidine protein methyltransferase 1 homolog
Translationally-controlled tumor protein
Complete loss of autocatalytic processing.
NACHT, LRR and PYD domains-containing protein 1a allele 1
NACHT, LRR and PYD domains-containing protein 1a, C-terminus
NACHT, LRR and PYD domains-containing protein 1a, N-terminus
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Sorting and assembly machinery component 50 homolog
N-acetylthreonine; in NHP2-like protein 1, N-terminally processed
NHP2-like protein 1, N-terminally processed
Loss of Golgi and secretory vesicle localization; when associated with G-5. Loss of axonal polarization; when associated with G-5. Increased dendrite localization without affecting association with microtubules; when associated with G-5.
Loss of palmitoylation. Loss of Golgi and secretory vesicle localization; when associated with G-10 and G-11. Loss of axonal polarization; when associated with G-10 and G-11. Increased dendrite localization without affecting association with microtubules; when associated with G-10 and G-11.
Signaling threshold-regulating transmembrane adapter 1
Insulin-like growth factor-binding protein complex acid labile subunit
Low-density lipoprotein receptor-related protein
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Endoplasmic reticulum metallopeptidase 1
Voltage-gated potassium channel subunit beta-1
Corticotropin-releasing factor receptor 1
Sodium- and chloride-dependent GABA transporter 2
Adipocyte plasma membrane-associated protein
SH3 and multiple ankyrin repeat domains protein 1
Leucine-rich repeat flightless-interacting protein 2
20% of wild-type transporter activity. No effect on cell membrane localization.
40% of wild-type transporter activity. No effect on cell membrane localization.
60% of wild-type transporter activity. No effect on cell membrane localization.
Electroneutral sodium bicarbonate exchanger 1
Non-structural maintenance of chromosomes element 1 homolog
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Caseinolytic peptidase B protein homolog
Impaired cell surface expression, and reduced interaction with NRXN1.
Steroidogenic acute regulatory protein, mitochondrial
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Trafficking protein particle complex subunit 1
Epithelial-stromal interaction protein 1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Fibronectin type III domain-containing protein 10
Transmembrane emp24 domain-containing protein 9
Methionine-R-sulfoxide reductase B2, mitochondrial
C5a anaphylatoxin chemotactic receptor 1
Probable ribosome biogenesis protein RLP24
Secretory carrier-associated membrane protein 1
Cilia- and flagella-associated protein 157
Dihydroxyacetone phosphate acyltransferase
NADPH:adrenodoxin oxidoreductase, mitochondrial
Abolishes nuclear localization and phosphorylation.
Cell cycle regulator of non-homologous end joining
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Low-density lipoprotein receptor-related protein 2
PxLPxI/L motif 1; mediates interaction with ANKRA2
PxLPxI/L motif 2; mediates interaction with ANKRA2
Reduced interaction with ARH and dynein.
Serine protease inhibitor Kazal-type 1-like
Neuronal vesicle trafficking-associated protein 1
Plasma membrane calcium-transporting ATPase 1
Insulin-like growth factor-binding protein 3
CUB and zona pellucida-like domain-containing protein 1
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Mitogen-activated protein kinase kinase kinase 7
Complex I assembly factor TIMMDC1, mitochondrial
Alters mode of dimerization, but does not abolish dimerization.
No effect on dimerization. Loss of dimerization; when associated with I-257.
No effect on dimerization. Loss of dimerization; when associated with I-266.
Tumor necrosis factor receptor superfamily member 16
Coiled-coil domain-containing protein 93
Carnitine O-palmitoyltransferase 1, brain isoform
Cyclin-D-binding Myb-like transcription factor 1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Cytochrome b-c1 complex subunit Rieske, mitochondrial
Interleukin-1 receptor-associated kinase-like 2
Regulator of G-protein signaling 7-binding protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Adrenocortical dysplasia protein homolog
Low affinity immunoglobulin gamma Fc region receptor II
Phosphotyrosine; by SRC-type Tyr-kinases
Rab3 GTPase-activating protein non-catalytic subunit
Spindle and kinetochore-associated protein 1
In isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
KH domain-containing, RNA-binding, signal transduction-associated protein 1
Transient receptor potential cation channel subfamily V member 4
Eukaryotic translation initiation factor 4H
Trimeric intracellular cation channel type A
Ankyrin repeat and zinc finger domain-containing protein 1
Solute carrier organic anion transporter family member 1A6
Inactive 2'-5'-oligoadenylate synthase 1B
Isocitrate dehydrogenase [NADP], mitochondrial
Transient receptor potential cation channel subfamily V member 2
Pyridoxal phosphate phosphatase PHOSPHO2
Leucine-rich repeat transmembrane neuronal protein 4
Mitochondrial sodium/calcium exchanger protein
Trafficking protein particle complex subunit 2
Misincorporates T nucleotide opposite G/C template.
Interchain (between light and heavy chains)
Serine/threonine-protein phosphatase with EF-hands 1
Neuroblastoma suppressor of tumorigenicity 1
Leucine-rich repeat-containing protein 73
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
Transcription elongation factor A protein-like 8
Alanine--glyoxylate aminotransferase 2, mitochondrial
Glutathione-specific gamma-glutamylcyclotransferase 1
Potassium voltage-gated channel subfamily KQT member 3
Voltage-dependent L-type calcium channel subunit beta-2
Probable proline--tRNA ligase, mitochondrial
Decreased rhodanese activity; unaltered MST activity.
Unaltered rhodanese activity; increased MST activity.
Microtubule-associated proteins 1A/1B light chain 3A
Chorion-specific transcription factor GCMa
Ubiquinol-cytochrome-c reductase complex assembly factor 3
Brain-enriched guanylate kinase-associated protein
Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin.
Voltage-dependent L-type calcium channel subunit alpha-1D
Cytochrome c oxidase subunit 8B, mitochondrial
Cell surface glycoprotein CD200 receptor 1
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
In isoform 4, isoform 5, isoform 6 and isoform 8.
V-type proton ATPase subunit B, brain isoform
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Transcription termination factor 1, mitochondrial
Lysosome-associated membrane glycoprotein 2
DNA replication complex GINS protein SLD5
DNA replication complex GINS protein SLD5, N-terminally processed
N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processed
Heparan sulfate glucosamine 3-O-sulfotransferase 2
NADPH-dependent 3-keto-steroid reductase Hsd3b5
Dihydropyrimidine dehydrogenase [NADP(+)]
Patatin-like phospholipase domain-containing protein 7
2-iminobutanoate/2-iminopropanoate deaminase
39S ribosomal protein L22, mitochondrial
C-Jun-amino-terminal kinase-interacting protein 3
AT-rich interactive domain-containing protein 4B
GDP-fucose protein O-fucosyltransferase 1
Transmembrane and coiled-coil domain-containing protein 4
Leucine-rich repeat transmembrane neuronal protein 1
Neutrophil gelatinase-associated lipocalin
GTP:AMP phosphotransferase AK3, mitochondrial
Cell division cycle-associated protein 7
Isocitrate dehydrogenase [NAD] subunit, mitochondrial
Eukaryotic translation initiation factor 2-alpha kinase 1
Putative sodium-coupled neutral amino acid transporter 10
Isoamyl acetate-hydrolyzing esterase 1 homolog
ATP synthase subunit delta, mitochondrial
85/88 kDa calcium-independent phospholipase A2
Voltage-gated potassium channel subunit beta-3
Granulocyte-macrophage colony-stimulating factor
N-acylethanolamine-hydrolyzing acid amidase
N-acylethanolamine-hydrolyzing acid amidase subunit alpha
N-acylethanolamine-hydrolyzing acid amidase subunit beta
Receptor-type tyrosine-protein phosphatase S
Abolishes nuclear localization; when associated with A-231.
Abolishes nuclear localization; when associated with A-233.
Fails to enhance GH-induced membrane ruffling; when associated with F-439.
Fails to enhance GH-induced membrane ruffling; when associated with F-494.
Phosphoserine; by MAPK1 or MAPK3; in vitro
Phosphotyrosine; by JAK1, JAK2 and PDGFR
Reduces in vitro phosphorylation by MAPK1 and/or MAPK3.
Reduces interaction with JAK2 and abolishes JAK2 kinase activity; reduces GH-stimulated cell motility; abolishes interaction with PDGFRA.
Reduces phosphorylation by JAK1 and JAK2.
Reduces phosphorylation by JAK1, JAK2 and PDGFRA.
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Vesicular, overexpressed in cancer, prosurvival protein 1
Cysteine sulfenic acid (-SOH); alternate
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate
Glycerophosphocholine phosphodiesterase GPCPD1
Loss of one glycosylation site. No effect on C.botulinum neurotoxin type A (BoNT/A, botA) binding, but reduces the uptake of BoNT/A.
Protein tyrosine phosphatase receptor type C-associated protein
LysM and putative peptidoglycan-binding domain-containing protein 3
Constitutive activation causing cell death.
Constitutive activation causing cell death. Activated at lower pH; when associated with A-72.
Constitutive activation causing cell death. Inactive; when associated with F-443.
Inactive. Active at lower pH; when associated with V-430.
Loss of function. Inactive; when associated with F-430.
No effect on pH dependence and function.
Reduces N-glycosylation. Abolishes N-glycosylation; when associated with S-365.
Reduces N-glycosylation. Abolishes N-glycosylation; when associated with S-392.
Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain
Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain
Loss of magnesium-binding; when associated with A-73, A-109 and Q-120.
Loss of magnesium-binding; when associated with A-73, Q-84 and A-109.
Loss of magnesium-binding; when associated with A-73, Q-84 and Q-120.
Loss of magnesium-binding; when associated with Q-84, A-109 and Q-120.
Aldehyde dehydrogenase, dimeric NADP-preferring
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Abolishes response to 2'-3' linked cGAMP and 3'-3' linked cGAMP and production of interferon IFNB1.
Decreases response to 2'-3' linked cGAMP and 3'-3' linked cGAMP and production of interferon IFNB1.
No effect on response to 2'-3' linked cGAMP and production of interferon IFNB1. Strongly increases affinity for the synthetic compound 5,6-dimethylxanthenone 4-acetic acid (DMXAA).
X-box-binding protein 1, cytoplasmic form
Cell death-inducing p53-target protein 1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Heterogeneous nuclear ribonucleoprotein A3
Inhibits interaction with ZDHHC13 and ZDHHC17.
In isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.
In isoform 4, isoform 5, isoform 6 and isoform 7.
Ankyrin repeat domain-containing protein 34A
T-cell surface glycoprotein CD8 alpha chain
Microtubule-associated serine/threonine-protein kinase 1
Abolishes binding to NUCB1. Dramatically decreases binding to CCDC88A. Does not affect GTP-binding activity but increases the basal exchange rate.
Dramatically decreases binding to CCDC88A.
Dramatically decreases interaction with NUCB1.
Guanine nucleotide-binding protein G(i) subunit alpha-3
No effect on promotion of cell migration or GTP-binding activity. Increases sensitivity to activation by CCDC88A.
Reduces cell migration by 50% and increases mitosis six-fold.
39S ribosomal protein L51, mitochondrial
Beclin 1-associated autophagy-related key regulator
Structural maintenance of chromosomes protein 1A
Polypeptide N-acetylgalactosaminyltransferase 5
Mediator of RNA polymerase II transcription subunit 20
Basic leucine zipper transcriptional factor ATF-like 3
Diphosphoinositol polyphosphate phosphohydrolase 1
O-linked (GalNAc...) serine; in soluble form
Sister chromatid cohesion protein PDS5 homolog A
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Transcription elongation factor A protein 1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Aldehyde dehydrogenase family 3 member B1
10-fold more potently inhibited by the alpha-conotoxin RgIA.
Abolishes dependency on RIC3 for functional expression.
Impairs dependency on RIC3 for functional expression.
Neuronal acetylcholine receptor subunit alpha-7
No change in inhibition by the alpha-conotoxin RgIA.
No effect on dependency on RIC3 for functional expression.
Slightly impairs dependency on RIC3 for functional expression.
Lysosome-associated membrane glycoprotein 5
Loss of localization to the late endosomes and redistribution to the cytoplasm.
Ral GTPase-activating protein subunit alpha-1
ATP-sensitive inward rectifier potassium channel 10
Sodium-coupled neutral amino acid transporter 9
Nuclear receptor subfamily 2 group C member 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Platelet endothelial cell adhesion molecule
Histone acetyltransferase type B catalytic subunit
Mediates head to head self-assembly of N-terminal ends
BMP and activin membrane-bound inhibitor homolog
Solute carrier family 2, facilitated glucose transporter member 1
Potassium voltage-gated channel subfamily H member 7
ADP-ribosylcysteine; by autocatalysis; in irreversibly inhibited form
Abolishes S-nitrosylation and subsequent nuclear translocation.
Abolishes interaction and subsequent nitrosylation of SIRT1.
Glyceraldehyde-3-phosphate dehydrogenase
S-nitrosocysteine; in reversibly inhibited form
Cytosolic Fe-S cluster assembly factor NUBP1
Calcium/calmodulin-dependent protein kinase type 1
Loss of activation by CaMKK1 and CaMKK2.
Partially excluded from the nucleus; when associated with 319-AQA-321.
Retention in the nucleus. Partially excluded from the nucleus; when associated with 263-AA-264.
Phosphotyrosine; by autocatalysis and SRC
Vascular endothelial growth factor receptor 3
Receptor-type tyrosine-protein phosphatase zeta
Cytoplasmic dynein 1 intermediate chain 1
5'-AMP-activated protein kinase catalytic subunit alpha-1
Allosterically activated by AMP but is not protected against dephosphorylation by AMP or ADP.
Decreases arachidonic acid 12 lipoxygenase. Exhibits an arachidonic acid 15 lipoxygenase. Decreases hepoxilin A3 synthase activity.
Does not affect arachidonic acid 12 lipoxygenase. Does not affects hepoxilin A3 synthase activity.
Polyunsaturated fatty acid lipoxygenase ALOX15
Complete loss of receptor functionality.
TRAF-interacting protein with FHA domain-containing protein A
Serine protease hepsin non-catalytic chain
Disintegrin and metalloproteinase domain-containing protein 1
Neutral and basic amino acid transport protein rBAT
Aspartate dehydrogenase domain-containing protein
Protein-glutamine gamma-glutamyltransferase 4
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Ubiquitin carboxyl-terminal hydrolase 15
Complex I assembly factor ACAD9, mitochondrial
Decreased homooligomerization and loss of formation of a ternary complex between GIT1, ARHGEF7 and PCLO. Does not affect ARHGEF7- and PCLO-binding to GIT1 monomer.
Loss of interaction with FAK1, decreased interaction with PCLO, no effect on interaction with ARHGEF7.
Loss of interaction with PCLO and FAK1, no effect on interaction with ARHGEF7.
Ig-like V-type 1; required for binding to polymeric IgA and IgM
Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-384 and F-429.
Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-384 and F-445.
Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-429 and F-445.
Inhibits actin polymerization; when associated with A-368.
Inhibits actin polymerization; when associated with A-381.
Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-384 and E-429.
Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-384 and E-445.
Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-429 and E-445.
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
Coiled-coil domain-containing protein 90B, mitochondrial
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
DNA-directed RNA polymerase I subunit RPA12
Fibronectin type III domain-containing protein 5
Calcium release-activated calcium channel protein 1
Short transient receptor potential channel 1
Steroid 17-alpha-hydroxylase/17,20 lyase
RNA polymerase II subunit B1 CTD phosphatase Rpap2
Phosphatidylinositol-glycan biosynthesis class W protein
B box and SPRY domain-containing protein
Potassium voltage-gated channel subfamily H member 3
Eukaryotic translation initiation factor 4E
Dephospho-CoA kinase domain-containing protein
PC-esterase domain-containing protein 1B
ATP-binding cassette sub-family D member 1
Cardiac-enriched FHL2-interacting protein
Abolishes neurabin-1 and neurabin-2 binding.
No effect on neurabin-1 and neurabin-2 binding.
Trans-Golgi network integral membrane protein TGN38
Nuclear factor interleukin-3-regulated protein
POU domain, class 4, transcription factor 2
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Abolishes interaction with TESC and markedly reduces transporter activity. Does not alter its cell membrane localization.
Phenylalanine--tRNA ligase alpha subunit
Disintegrin and metalloproteinase domain-containing protein 7
Mitochondrial import inner membrane translocase subunit Tim22
Activity-regulated cytoskeleton-associated protein
Phosphoinositide-3-kinase-interacting protein 1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Coiled-coil and C2 domain-containing protein 1A
Glucose-dependent insulinotropic receptor
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Calcium-independent mitochondrial carrier protein SCaMC-3L
No significant effect on enzyme activity or subcellular location.
Ornithine aminotransferase, mitochondrial
Does not inhibit F-actin retrograde flow at the peripheral region of growth cones; when associated with D-101.
Does not inhibit F-actin retrograde flow at the peripheral region of growth cones; when associated with D-249.
Inhibits F-actin retrograde flow at the peripheral region of growth cones; when associated with A-101.
Inhibits F-actin retrograde flow at the peripheral region of growth cones; when associated with A-249.
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Acyl-coenzyme A synthetase ACSM2, mitochondrial
Platelet-activating factor acetylhydrolase 2, cytoplasmic
Mitochondrial ribonuclease P catalytic subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Prostate tumor-overexpressed gene 1 protein homolog
tRNA wybutosine-synthesizing protein 2 homolog
Decreased MST activity; increased rhodanese activity.
Interchain (with C-155 or C-264); redox-active
Large decrease in MST activity; some decrease in rhodanese activity.
Loss of both enzyme activities. Greatly reduced redox potential.
Slight decrease in MST activity; increased rhodanese activity.
Dihydrolipoyl dehydrogenase, mitochondrial
Abolishes NMDA receptor-dependent long-lasting depression.
Dominant negative. Abolishes depression of AMPAR-mediated transmission. Abolishes NMDA receptor-dependent long-lasting depression.
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Sodium/potassium-transporting ATPase subunit alpha-4
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Rho family-interacting cell polarization regulator 1
Nuclear envelope integral membrane protein 2
SUN domain-containing ossification factor
Defects in binding to phosphatidylinositol-3-phosphate and in formation of GPHN clusters.
No effect on GPHN clusters; when associated with A-107 and A-108.
No effect on GPHN clusters; when associated with A-107 and A-117.
No effect on formation of GPHN clusters; when associated with A-108 and A-117.
Rho guanine nucleotide exchange factor 9
POU domain, class 4, transcription factor 1
EF-hand calcium-binding domain-containing protein 4A
Calmodulin-regulated spectrin-associated protein 2
Non-canonical dileucine endocytic signal
FXYD domain-containing ion transport regulator 5
tRNA N6-adenosine threonylcarbamoyltransferase
Phosphoserine; by PKA and PKB/AKT1 or PKB/AKT2
2'-5'-oligoadenylate synthase-like protein 1
Leucine-rich repeat-containing protein 34
KN motif and ankyrin repeat domain-containing protein 2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Actin, aortic smooth muscle, intermediate form
Tumor necrosis factor receptor superfamily member 6
Abolishes interaction with HOMER1 isoform 3.
Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation.
Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation. Disrupts axonal growth cone motility. Slightly increases interaction with SHARPIN and SPTAN1. No effect on localization.
Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation. Slightly decreases interaction with SHARPIN and SPTAN1. No effect on localization.
SH3 and multiple ankyrin repeat domains protein 3
Slightly increases interaction with SHARPIN and SPTAN1. No effect on localization.
Strongly decreases interaction with ABI1.
Oxidized low-density lipoprotein receptor 1
Oxidized low-density lipoprotein receptor 1, soluble form
PEST proteolytic signal-containing nuclear protein
Impairs internalization; decreases interaction with AP2M1.
Receptor-type tyrosine-protein phosphatase N2
Tubulin-specific chaperone cofactor E-like protein
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Solute carrier organic anion transporter family member 4C1
Submandibular glandular kallikrein-9 heavy chain
Submandibular glandular kallikrein-9 light chain
Eukaryotic translation initiation factor 3 subunit I
In isoform 2, isoform 4, isoform 6 and isoform 8.
In isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
In isoform 5, isoform 6, isoform 7 and isoform 8.
Inositol 1,4,5-trisphosphate receptor type 1
Phosphoserine; by IKKB, MAPK8 and RPS6KB1
Potassium voltage-gated channel subfamily G member 1
Apoptosis facilitator Bcl-2-like protein 14
Volume-regulated anion channel subunit LRRC8D
Peptidyl-prolyl cis-trans isomerase FKBP1B
Strong reduction in secretin (SCT)-binding.
Cytochrome c oxidase subunit 8A, mitochondrial
N-acetylserine; in Prothymosin alpha, N-terminally processed
Prothymosin alpha, N-terminally processed
Decreased affinity for manganese. Decreased inhibition by AMP and GMP.
Increased affinity for manganese. Decreased inhibition by AMP and GMP.
Loss of phosphodiesterase activity. Disrupts metal cofactor binding.
Induces a redistribution from both the nucleus and cytoplasm to only the cytoplasm.
Suppression of tumorigenicity 18 protein
In isoform ZA, isoform ZB, isoform ZC, isoform ZD, isoform ZE and isoform ZF.
Plasma membrane calcium-transporting ATPase 3
Choline-phosphate cytidylyltransferase B
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Significantly disrupts Golgi apparatus localization. Decreases galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Impairs secretion and interaction with SAR1A.
Coiled-coil domain-containing protein 22
Ectonucleoside triphosphate diphosphohydrolase 5
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Probable phospholipid-transporting ATPase IIB
Important for interaction with G proteins
Parathyroid hormone/parathyroid hormone-related peptide receptor
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
Ubiquitin carboxyl-terminal hydrolase 10
Uncharacterized protein C11orf96 homolog
Basic helix-loop-helix ARNT-like protein 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)
Inactive hydroxysteroid dehydrogenase-like protein 1
Cyclic AMP-responsive element-binding protein 3-like protein 2
Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Splicing regulatory glutamine/lysine-rich protein 1
LETM1 domain-containing protein LETM2, mitochondrial
Cyclic AMP-dependent transcription factor ATF-2
Phosphoserine; by PKC/PRKCA and PKC/PRKCB
Tectonin beta-propeller repeat-containing protein 1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Microtubule-associated protein RP/EB family member 3
Hippocampus abundant transcript-like protein 1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Growth arrest and DNA damage-inducible proteins-interacting protein 1
Mas-related G-protein coupled receptor member E
Aflatoxin B1 aldehyde reductase member 3
Potassium voltage-gated channel subfamily H member 4
Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-477 and F-501.
Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-460; F-477 and F-501.
Strongly reduces insulin-induced tyrosine phosphorylation and PTPN11 binding. Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-460 and F-477.
Strongly reduces insulin-induced tyrosine phosphorylation and PTPN11 binding. Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-460 and F-501.
Tyrosine-protein phosphatase non-receptor type substrate 1
Neurogenic locus notch homolog protein 1
O-linked (GalNAc...) threonine; alternate
Receptor-type tyrosine-protein phosphatase epsilon
Short transient receptor potential channel 2
Regenerating islet-derived protein 3-alpha 15 kDa form
Regenerating islet-derived protein 3-alpha 16.5 kDa form
Increased glutamate and glycine agonist potency.
Coiled-coil and C2 domain-containing protein 1B
Odontogenic ameloblast-associated protein
Zinc finger and BTB domain-containing protein 7A
ADP-ribosylation factor-like protein 6-interacting protein 6
Corticotropin-releasing factor receptor 2
Predominantly occurs as a monomer, less than 10% occurs as dimer.
Probable E3 ubiquitin-protein ligase IRF2BPL
Affects PtdIns(4,5)P2-binding, plasma membrane-association but not binding to DCVs.
Transient receptor potential cation channel subfamily M member 1
Vasoactive intestinal polypeptide receptor 2
SUMO interaction motif 1 (SIM); crucial for efficient sumoylation
Pleckstrin homology-like domain family A member 3
tRNA (cytosine(38)-C(5))-methyltransferase
Increased localization to the plasma membrane.
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Fanconi anemia core complex-associated protein 20
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Linker for activation of T-cells family member 2
Glucocorticoid modulatory element-binding protein 1
Acyl-CoA-binding domain-containing protein 4
Loss of enzymatic activity; when associated with T-636 change in subcellular location, loss of PMA-induced down-regulation and loss of enzymatic activity.
Loss of enzymatic activity; when associated with T-643 change in subcellular location, loss of PMA-induced down-regulation and loss of enzymatic activity.
Complement C1q tumor necrosis factor-related protein 1
N-acetylthreonine; in GTPase KRas, N-terminally processed
Ubiquitin-conjugating enzyme E2 variant 2
Transcription termination factor 3, mitochondrial
PxLPxI/L motif; mediates interaction with ANKRA2 and 14-3-3 proteins
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644: A-933; A-1022 and A-1175.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-1022 and A-1175.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-933 and A-1022.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-933 and A-1175.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-806; A-933; A-1022 and A-1175.
Rap guanine nucleotide exchange factor 2
Abolishes interaction with DLG4. Does not redistribute DLG4 to microtubules. Associates with microtubules.
Abolishes interaction with DLG4. Strongly abolishes interaction with DLG4; when associated with D-100.
Abolishes interaction with DLG4. Strongly abolishes interaction with DLG4; when associated with E-98.
Phosphatidylinositol 3-kinase regulatory subunit gamma
Phosphatidylinositol-binding clathrin assembly protein
Interchain (between alpha-2-3 and delta-3 chains)
Voltage-dependent calcium channel subunit alpha-2-3
Voltage-dependent calcium channel subunit alpha-2/delta-3
Voltage-dependent calcium channel subunit delta-3
Barrier-to-autointegration factor, N-terminally processed
N-acetylthreonine; in Barrier-to-autointegration factor, N-terminally processed
Meiosis regulator and mRNA stability factor 1
Mapk-regulated corepressor-interacting protein 1
Loss of inhibition of KCNH2 channel stimulation.
Slightly reduces activation by arachidonic acid.
Natural cytotoxicity triggering receptor 1
Decreased calcium-dependent inhibition of autophosphorylation.
Loss of kinase activity; when associated with K-250.
Reduced ability of autoinhibitory domain to regulate kinase activity.
Reduced kinase activity. Loss of kinase activity; when associated with G-233.
NACHT, LRR and PYD domains-containing protein 6
Guanine nucleotide-binding protein subunit alpha-13
V-type proton ATPase 116 kDa subunit a 1
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Impairs interaction with dynein intermediate chain (DYNC1I1 or DYNC1I2).
No effect on interaction with dynein intermediate chain (DYNC1I1 or DYNC1I2).
Potassium voltage-gated channel subfamily G member 2
N6,N6,N6-trimethyllysine; by EHMT2; alternate
N6,N6-dimethyllysine; by EHMT2; alternate
Neuronal PAS domain-containing protein 4
Acyl-coenzyme A synthetase ACSM5, mitochondrial
Death domain-containing membrane protein NRADD
Channel conformation is shifted toward the open state.
Voltage-dependent anion-selective channel protein 1
Mitochondrial antiviral-signaling protein
Reduced decay of target mRNA. No effect on GTP binding.
Reduced decay of target mRNA. Reduced GTPase activity.
Reduced decay of target mRNA. Slightly reduced GTPase activity. No effect on GTP binding.
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Processed zona pellucida sperm-binding protein 3
Multiple inositol polyphosphate phosphatase 1
14-3-3 protein beta/alpha, N-terminally processed
N-acetylthreonine; in 14-3-3 protein beta/alpha, N-terminally processed
ATP-binding cassette sub-family G member 5
Uncharacterized protein C1orf105 homolog
Abolishes agrin-dependent activation and autophosphorylation.
Muscle, skeletal receptor tyrosine protein kinase
Reduces LRP4- and AGRIN-dependent phosphorylation. Reduces DOK7-dependent phosphorylation. Reduces agrin-dependent AChR aggregation in neuromuscular junction. Reduces interaction with DOK7.
Strongly reduced agrin-dependent activation and autophosphorylation.
Phytanoyl-CoA hydroxylase-interacting protein-like
Loss of activity. Loss of MAPK14 phosphorylation and of PCDH8 internalization.
CCR4-NOT transcription complex subunit 9
Actin, gamma-enteric smooth muscle, intermediate form
Protein phosphatase 1 regulatory subunit 7
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Processed angiotensin-converting enzyme 2
Heterogeneous nuclear ribonucleoprotein K
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Aldehyde dehydrogenase family 3 member A2
11-beta-hydroxysteroid dehydrogenase type 2
Sodium- and chloride-dependent betaine transporter
ATPase family AAA domain-containing protein 3
Polyadenylate-binding protein-interacting protein 2
Hepatoma-derived growth factor-related protein 2
Growth hormone-releasing hormone receptor
Mesoderm induction early response protein 1
Ankyrin repeat domain-containing protein 16
Processed sterol regulatory element-binding protein 1
Sterol regulatory element-binding protein 1
Mannan-binding lectin serine protease 2 A chain
Mannan-binding lectin serine protease 2 B chain
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Tubulin polymerization-promoting protein
Short transient receptor potential channel 3
Glycerol-3-phosphate acyltransferase 1, mitochondrial
Abolishes binding to phosphatidylinositol 3-phosphate.
Slightly reduced activity. Loss of activity for sugars; when associated with F-143 and L-146.
Slightly reduced activity. Loss of activity for sugars; when associated with M-137 and L-146.
Slightly reduced activity. Loss of activity for sugars; when associated with M-137; F-143 and L-146.
Slightly reduced activity. Loss of activity for sugars; when associated with S-191.
Slightly reduced activity. Loss of activity for sugars; when associated with V-190.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-31 and A-35.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-31 and A-38.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-35 and A-38.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-31; A-35 and A-38.
50% loss of zinc binding; when associated with Q-12; Q-14 and Q-16.
50% loss of zinc binding; when associated with Q-12; Q-14 and Q-24.
50% loss of zinc binding; when associated with Q-12; Q-16 and Q-24.
50% loss of zinc binding; when associated with Q-14; Q-16 and Q-24.
Abolishes localization at trans-Golgi network (TGN) and affects the integrity of the TGN. Inhibits retrograde trafficking of M6PR-associated vesicles.
Abolishes S-nitrosylation and subsequent interaction with GAPDH.
Membrane-associated progesterone receptor component 1
Ubiquitin/ISG15-conjugating enzyme E2 L6
Glucan phosphatase signature motif CXAGXGR
Sodium-dependent neutral amino acid transporter B(0)AT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
Bifunctional peptidase and arginyl-hydroxylase JMJD5
Nuclear transcription factor Y subunit alpha
Peroxisome proliferator-activated receptor gamma
Potassium voltage-gated channel subfamily S member 2
Peptidyl-prolyl cis-trans isomerase FKBP9
Induces loss of filamentous network when coexpressed with nestin.
Phosphoserine; by CaMK2, PKA, PKC and ROCK2
Phosphoserine; by PKA and PKC; alternate
Retains filamentous network during mitosis when transfected alone and when coexpressed with nestin.
Motile sperm domain-containing protein 1
Tumor protein p63-regulated gene 1-like protein
Sodium/potassium-transporting ATPase subunit gamma
Nuclear speckle splicing regulatory protein 1
Loss of Ca(2+)-binding in the first C2 domain; when associated with N-172.
Loss of Ca(2+)-binding in the first C2 domain; when associated with N-225.
Pleckstrin homology domain-containing family D member 1
Isoglutamyl cysteine thioester (Cys-Gln)
von Willebrand factor A domain-containing protein 3A
Neurotrophin receptor-interacting factor 1
Intraflagellar transport protein 46 homolog
15% of wild-type lysophospholipase D activity.
20% of wild-type lysophospholipase D activity.
Abolishes secretion. Strongly reduced lysophospholipase activity.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Impaired secretion. No effect on lysophospholipase activity.
Phosphoserine; by autocatalysis and TRPM7
Intraflagellar transport protein 81 homolog
Mothers against decapentaplegic homolog 1
Phosphothreonine; by MINK1, TNIK and MAP4K4
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Ribosome-recycling factor, mitochondrial
Ankyrin repeat and BTB/POZ domain-containing protein 2
Mothers against decapentaplegic homolog 9
A disintegrin and metalloproteinase with thrombospondin motifs 7
Pituitary adenylate cyclase-activating polypeptide 27
Pituitary adenylate cyclase-activating polypeptide 38
Sodium- and chloride-dependent creatine transporter 1
Dyslexia-associated protein KIAA0319 homolog
Coiled-coil domain-containing protein 105
PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Disintegrin and metalloproteinase domain-containing protein 2
Translation initiation factor eIF-2B subunit alpha
Regulating synaptic membrane exocytosis protein 3
Glutamate receptor ionotropic, kainate 1
In isoform Glur5-2B and isoform Glur5-2.
Fails to induce mitochondrial fragmentation and mitochondrial targeting. Fail to induce mitochondrial fragmentation; when associated with A-213.
Fails to induce mitochondrial fragmentation. Fail to induce mitochondrial fragmentation; when associated with A-212.
Fails to induce mitochondrial fragmentation; when associated with A-211.
Fails to induce mitochondrial fragmentation; when associated with A-212.
Synaptic vesicle membrane protein VAT-1 homolog
Ras association domain-containing protein 6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
RCC1 and BTB domain-containing protein 2
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Abolishes interaction with FLRT2; when associated with N-89.
Abolishes interaction with FLRT2; when associated with T-91.
Polypeptide N-acetylgalactosaminyltransferase
Killer cell lectin-like receptor subfamily B member 1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Acid sphingomyelinase-like phosphodiesterase
Mucosal addressin cell adhesion molecule 1
Leucine-rich repeat-containing protein 26
Dimeric form; when associated with E-349. Does not form the high-order complex with SHANK1; when associated with E-349. Does not change its interaction with STX12; when associated with E-349. Reduces localization to the spine; when associated with E-349. Affects dendritic spine structure; when associated with E-349. Decreases synaptic transmission; when associated with E-349. Does not affect glutamate receptors ratio; when associated with E-349.
Dimeric form; when associated with R-344. Does not form the high-order complex with SHANK1; when associated with R-344. Does not change its interaction with STX12; when associated with R-344. Reduces localization to the spine; when associated with R-344. Affects dendritic spine structure; when associated with R-344. Decreases synaptic transmission; when associated with R-344. Does not affect glutamate receptors ratio; when associated with R-344.
Disrupts binding to both GRM1 and SHANK3. Does not form the high-order complex with SHANK1.
Eliminates binding to both GRM1 and SHANK3.
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Melanin-concentrating hormone receptor 1
N-acetylthreonine; in Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed
Receptor of activated protein C kinase 1
Receptor of activated protein C kinase 1, N-terminally processed
Serine/threonine-protein kinase receptor
Abolishes interaction with TJP1; when associated with Q-952.
Abolishes interaction with TJP1; when associated with Q-954.
Abolishes interaction with TJP1; when associated with Q-964.
Abolishes interaction with TJP1; when associated with Q-966.
Serine/threonine-protein kinase MRCK beta
Decreased autophosphorylation; when associated with A-189.
Decreased autophosphorylation; when associated with A-193.
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Loss of GABA and glycine transport activity. Loss of potential gradient-induced Cl(-) uptake. Loss of beta-alanine transport activity.
Retains around 80% of the beta-alanine transport activity.
Vesicular inhibitory amino acid transporter
Interchain (between beta and alpha chains)
Glycosyltransferase 8 domain-containing protein 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
Leucine-rich repeat-containing protein 42
Zinc finger and BTB domain-containing protein 8A
Amyloid-beta A4 precursor protein-binding family B member 3
Gamma-aminobutyric acid receptor subunit alpha-3
Does not affect phosphorylation by MAPKAPK2.
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Neuronal acetylcholine receptor subunit alpha-2
Spindle and centriole-associated protein 1
Calcium/calmodulin-dependent protein kinase kinase 1
Decrease in phosphorylation and partial inhibition by PKA. Almost loss of inhibition by PKA; when associated with A-108.
Decrease in phosphorylation and partial inhibition by PKA. Almost loss of inhibition by PKA; when associated with A-458.
Loss of substrate recognition and interaction with CAMK4.
Potassium voltage-gated channel subfamily V member 1
Interchain (with C-1359 or C-1384 in LTBP1); in inactive form
Glial cell line-derived neurotrophic factor
Abolishes interaction with AP2B1; no effect on interaction with clathrin.
Abolishes interaction with CLTC; reduces interaction with AP2B1.
Almost abolishes phosphorylation; inhibits internalization of ADRB2; when associated with D-361.
Almost abolishes phosphorylation; inhibits internalization of ADRB2; when associated with D-383.
Greatly reduces interaction with MAPK10.
Inhibits internalization of EDNRA and EDNRB.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-107, R-108, R-207 and R-296.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-107, R-108 and R-207.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-107, R-108 and R-296.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-107, R-207 and R-296.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-108, R-207 and R-296.
Transient ubiquitination; no stable endocytic complexes with AGTR1; impaired in scaffolding-activated ERK1/2.
ATP-binding cassette subfamily G member 4
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
Protein kinase C delta type catalytic subunit
Protein kinase C delta type regulatory subunit
Isoaspartyl peptidase/L-asparaginase alpha chain
Isoaspartyl peptidase/L-asparaginase beta chain
Single-strand selective monofunctional uracil-DNA glycosylase
Cysteine sulfinic acid (-SO2H); alternate
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Coiled-coil domain-containing protein 117
C-type lectin domain family 2 member D-related protein
Dual specificity testis-specific protein kinase 2
Class-II-associated invariant chain peptide
H-2 class II histocompatibility antigen gamma chain
Abolished inhibitory effect of IFN-gamma on JNK1 activity.
Transient receptor potential cation channel subfamily M member 8
Uncharacterized protein C1orf112 homolog
Marginal zone B- and B1-cell-specific protein
Prostaglandin F2 receptor negative regulator
CCR4-NOT transcription complex subunit 6
Heterogeneous nuclear ribonucleoprotein A1
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Leucine zipper putative tumor suppressor 1
Developmental pluripotency-associated protein 3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
No effect on activity towards phosphatidylinositol 4-monophosphate. Lowers activity 5-fold towards phosphatidylinositol 4,5-bisphosphate.
POU domain, class 2, transcription factor 1
Ankyrin repeat and SAM domain-containing protein 3
Zinc finger FYVE domain-containing protein 21
Transient receptor potential cation channel subfamily M member 2
Myeloid-associated differentiation marker
A disintegrin and metalloproteinase with thrombospondin motifs 4
Eukaryotic translation initiation factor 3 subunit D
N6,N6,N6-trimethyllysine; by METTL21A; alternate
Transcriptional activator protein Pur-beta
Abolishes interaction with KLHL17. Abolishes actinfilin-mediated degradation.
Abolishes sumoylation. Loss of kainate-mediated endocytosis.
Glutamate receptor ionotropic, kainate 2
Impairs protein folding and abolishes location at the cell surface.
Ubiquitin carboxyl-terminal hydrolase 19
10-fold decrease in inhibition by the spider pi-theraphotoxin-Hm3a.
18-fold decrease in inhibition by the spider pi-theraphotoxin-Hm3a.
37-fold decrease in inbibition by the snake mambalgin-1 toxin. Very high decrease in inhibition by the snake mambalgin-2 toxin.
Complete loss in inhibition by 200 nM of the snake mambalgin-2 toxin.
Complete loss of inhibition by the spider Pi-hexatoxin-Hi1a, and by the snake mambalgin-2 toxin. Potentiated by the spider pi-theraphotoxin-Hm3a (at both pH 7.35 and 7.45) and inhibited at higher toxin concentration at pH 7.35. Complete loss in the shift of pH for both activation and desensitization by the spider venom psalmotoxin-1.
High decrease in inhibition by the snake mambalgin-2 toxin.
Moderate decrease in inhibition by the snake mambalgin-2 toxin.
No change in the shift of pH for both activation and desensitization by the spider venom psalmotoxin-1.
No effect on channel activation and inactivation.
No effect. Increases desensitization rates; when associated with L-84 and M-85.
No effect. Increases desensitization rates; when associated with P-83 and L-84.
No effect. Increases desensitization rates; when associated with P-83 and M-85.
No significant decrease in inhibition by the spider pi-theraphotoxin-Hm3a.
Reduction of Ca(2+) block. Loss of Ca(2+) block; when associated with C-432.
Reduction of Ca(2+) block. Loss of Ca(2+) block; when associated with G-425.
Small decrease in inhibition by the snake mambalgin-2 toxin; RDQ-KQE mutant.
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Pulmonary surfactant-associated protein B
Membrane-associated progesterone receptor component 2
Transcription elongation factor, mitochondrial
Loss of enzymatic activity. Reduces both membrane fusion during myogenesis and accumulation of muscle-specific proteins.
Polypeptide N-acetylgalactosaminyltransferase 10
Low molecular weight phosphotyrosine protein phosphatase
Leucine-rich repeat-containing protein 56
N-linked (GlcNAc...) (keratan sulfate) asparagine
Transcription initiation factor TFIID subunit 9
Distal membrane-arm assembly complex protein 2
Mas-related G-protein coupled receptor member B8
Abolishes catalytic activity. Disrupts interaction of MAP3K5/ASK1 with thioredoxin. Abolishes inhibition of MAP3K5 and activation of JNK1. No effect on interaction with MAP3K5.
Completely abolishes catalytic activity, but does not affect oligomerization.
Reduces catalytic activity 10-fold, and causes higher order oligomers of the protein.
Reduces catalytic activity 3000-fold, and causes higher order oligomers of the protein.
Reduces catalytic activity to 0.03%, but does not affect oligomerization.
Proline/serine-rich coiled-coil protein 1
Constitutively active. Constitutively interacts and stimulates PLCE1 phospholipase activity. Reduced interaction and stimulation of PLCE1; when associated with G-37 and N-38. No interaction and stimulation of PLCE1; when associated with S-35 and C-40. Interacts and partially stimulates PLCE1; when associated with G-26. Interacts but does not stimulate PLCE1; when associated with S-186.
Interacts and partially stimulates PLCE1; when associated with L-61.
Interacts but does not stimulate PLCE1; when associated with L-61.
N-acetylthreonine; in GTPase HRas, N-terminally processed
No interaction and stimulation of PLCE1; when associated with L-61.
Reduced interaction and stimulation of PLCE1; when associated with L-61.
S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate
Cytochrome c oxidase subunit 7B, mitochondrial
Does not affect Vmax for phenylalanine. Increases KM for phenylalanine.
Does not affect Vmax for phenylalaninet. Increases KM for phenylalanine.
Shifts substrate specificity from tyrosine to phenylalanine.
Immunity-related GTPase family M protein
Beta-crystallin B3, N-terminally processed
N-acetylalanine; in Beta-crystallin B3, N-terminally processed
Intraflagellar transport protein 172 homolog
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Nuclear receptor subfamily 1 group I member 2
26S proteasome non-ATPase regulatory subunit 9
von Willebrand factor A domain-containing protein 5A
Leucine-rich repeat-containing G-protein coupled receptor 4
CXXC motif containing zinc binding protein
CAP-Gly domain-containing linker protein 4
Ethanolamine-phosphate cytidylyltransferase
Inositol 1,4,5-trisphosphate receptor type 3
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
26S proteasome non-ATPase regulatory subunit 2
Zinc finger CCHC domain-containing protein 12
10-fold increase in affinity for calcium.
Complete loss of calcium-binding and calcium-dependent phospholipid binding activity.
Moderate increase in affinity for calcium.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
39S ribosomal protein L14, mitochondrial
snRNA-activating protein complex subunit 3
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Beta-crystallin A3, isoform A1, Delta4 form
Beta-crystallin A3, isoform A1, Delta7 form
Beta-crystallin A3, isoform A1, Delta8 form
Isoform A1. The measured range is 2-198.
Loss of phosphorylation by PKA. No effect on localization to synapse. Inhibits the spontaneous release of neurotransmitters.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Phosphatidylinositol glycan anchor biosynthesis class U protein
Dephenylalaninated tubulin alpha-8 chain
Cullin-associated NEDD8-dissociated protein 2
Uncharacterized protein C1orf131 homolog
Probable ATP-dependent RNA helicase DDX52
Chymotrypsin-like elastase family member 1
DRY motif; important for ligand-induced conformation changes and signaling
No reduction in stability, impaired ligand binding.
Small reduction in stability, impaired ligand binding.
Does not alter sorting to large dense granules.
Impairs sorting to large dense granules. Delivered to the plasma membrane instead.
Impairs sorting to large dense granules. Delivered to the plasma membrane instead. Abolishes exocytosis in dendrites. Reduces exocytosis in axons.
Loss of activity. Abolishes histamine uptake.
Eukaryotic translation initiation factor 5B
Completely abolishes formation of PSPP or squalene from FPP.
Completely eliminates the activities of both the first and the second reactions.
Does not affect squalene synthase activity.
Has little effect on the total squalene synthase activity.
Retains partial activity of the first reaction. Completely eliminates the activity of the second reaction.
Retains partial activity of the first reaction. Retains partial activity of the second reaction.
Ubiquitin carboxyl-terminal hydrolase 28
Cyclic AMP-dependent transcription factor ATF-4
Jupiter microtubule associated homolog 1
Jupiter microtubule associated homolog 1, N-terminally processed
N-acetylthreonine; in Hematological and neurological expressed 1 protein, N-terminally processed
Ubiquitin carboxyl-terminal hydrolase 42
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Acyl-CoA synthetase short-chain family member 3, mitochondrial
Gamma-aminobutyric acid receptor-associated protein
Doublesex and mab-3 related transcription factor 3
Potassium voltage-gated channel subfamily S member 1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Impaired light-induced proteasomal degradation.
No effect on light-induced proteasomal degradation.
No effect on light-induced proteasomal degradation; when associated with R-8, R-99 and R-168.
No effect on light-induced proteasomal degradation; when associated with R-99, R-133 and R-168.
No effect on proteasomal degradation; when associated with R-8, R-99 and R-133.
No effect onlight-induced proteasomal degradation; when associated with R-8, R-133 and R-168.
Transforming growth factor beta-1-induced transcript 1 protein
Exclusive nuclear localization. Shows a reduction in synaptic contacts and dendritic processes.
Extranuclear localization and reduced CABP1 and KPNA1 binding. Shows a reduction in synaptic contacts and dendritic processes.
NMDA receptor synaptonuclear signaling and neuronal migration factor
Coiled-coil domain-containing protein 174
Guanylate cyclase soluble subunit alpha-2
Polyamine-modulated factor 1-binding protein 1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Proprotein convertase subtilisin/kexin type 7
Histone-arginine methyltransferase METTL23
Constitutively GTP-bound and constitutively active.
Loss of subcellular location to plasma and endosomal membrane.
Loss of subcellular location to plasma and endosomal membranes.
Loss of subcellular location to plasma membrane, decreased association with endomembranes.
Loss of subcellular location to plasma membrane.
5'-AMP-activated protein kinase subunit gamma-1
Lamina-associated polypeptide 2, isoform beta
Cysteine sulfenic acid (-SOH) intermediate
Abolishes autophosphorylation. Retains marginal kinase activity towards histones.
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Reduced autophosphorylation on tyrosine, but retains some kinase activity towards histones.
Suppressed autophosphorylation on tyrosine and reduced tyrosine, threonine and serine kinase activity towards histones; when associated with F-319.
Suppressed autophosphorylation on tyrosine and reduced tyrosine, threonine and serine kinase activity towards histones; when associated with F-321.
ATP synthase F(0) complex subunit C1, mitochondrial
Ventricular zone-expressed PH domain-containing protein homolog 1
Heterogeneous nuclear ribonucleoprotein H2
Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
39S ribosomal protein L30, mitochondrial
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Calmodulin-regulated spectrin-associated protein 1
Leucine-rich repeat-containing protein 63
Ras association domain-containing protein 4
Important for ABL1-mediated Tyr-718 phosphorylation
SLIT-ROBO Rho GTPase-activating protein 2
Inhibits calcium-mediated conformational changes. Loss of transcytotic targeting/fusion function. Reduces association with membranes. Does not affect microtubule formation.
Necessary for association with microtubule and interaction with GAPDH
Predominantly located in the cytoplasm; when associated with A-138. Predominantly located in the nucleus; when associated with A-138; A-179 and A-180.
Predominantly located in the cytoplasm; when associated with A-139. Predominantly located in the nucleus; when associated with A-139; A-179 and A-180.
Predominantly located in the cytoplasm; when associated with A-143 and A-145. Predominantly located in the nucleus; when associated with A-143; A-145; A-183 and A-185.
Predominantly located in the cytoplasm; when associated with A-143 and A-147. Predominantly located in the nucleus; when associated with A-143; A-147; A-183 and A-185.
Predominantly located in the cytoplasm; when associated with A-145 and A-147. Predominantly located in the nucleus; when associated with A-145; A-147; A-183 and A-185.
Predominantly located in the cytoplasm; when associated with A-179. Predominantly located in the nucleus; when associated with A-138; A-139 and A-179.
Predominantly located in the cytoplasm; when associated with A-180. Predominantly located in the nucleus; when associated with A-138; A-139 and A-180.
Predominantly located in the cytoplasm; when associated with A-183. Predominantly located in the nucleus; when associated with A-143; A-145; A-147 and A-183.
Predominantly located in the cytoplasm; when associated with A-185. Predominantly located in the nucleus; when associated with A-143; A-145; A-147 and A-185.
Loss of phosphorylation and nuclear import.
Aberrant protein folding and disordered structure.
3-oxoacyl-[acyl-carrier-protein] reductase
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Chloride intracellular channel protein 6
Helical; Note=After insertion into the membrane
Meiotic recombination protein REC8 homolog
P2R1A-PPP2R2A-interacting phosphatase regulator 1
Nuclear receptor subfamily 1 group I member 3
Galactose-1-phosphate uridylyltransferase
Large neutral amino acids transporter small subunit 2
MAP kinase docking motif; essential for its phosphorylation
Ankyrin repeat domain-containing protein 1
Regenerating islet-derived protein 3-beta 15 kDa form
Regenerating islet-derived protein 3-beta 16.5 kDa form
Potassium voltage-gated channel subfamily S member 3
Pleckstrin homology domain-containing family M member 1
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
Loss of S-adenosylmethionine synthase activity, but does not abolish polyphosphatase activity.
S-adenosylmethionine synthase isoform type-1
Tetratricopeptide repeat protein 19, mitochondrial
N-acetylthreonine; in N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed
N-terminal Xaa-Pro-Lys N-methyltransferase 1
N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed
Basic leucine zipper transcriptional factor ATF-like
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Mislocalization in neurons from neurite tips to perinuclear region.
EF-hand calcium-binding domain-containing protein 3
N-linked (GlcNAc...) (high mannose) asparagine; alternate
N-linked (GlcNAc...) (hybrid) asparagine; alternate
POU domain, class 3, transcription factor 4
Receptor-interacting serine/threonine-protein kinase 3
Transcription termination factor 2, mitochondrial
IQ motif and SEC7 domain-containing protein 3
Bombesin receptor-activated protein C6orf89 homolog
Vitamin K-dependent protein C heavy chain
Vitamin K-dependent protein C light chain
Myelin-associated neurite-outgrowth inhibitor
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Protein-S-isoprenylcysteine O-methyltransferase
Increased activity and autophosphorylation.
Loss of kinase activity; autophosphorylation and dimerization.
>1000-fold reduction of sensitivity to the conotoxin GVIIJ(SSG).
Abolishes SUMOylation. No increase of voltage-gated sodium current upon hypoxia.
Blocks the reduction of Na+ current and the slowing of inactivation caused by PKC.
Increase in sensitivity to the scorpion toxin BMK M1.
Slowed inactivation and increased persistent current. Gain of function mutation.
Sodium channel protein type 2 subunit alpha
Sodium current is irreversibly blocked by methanethiosulfonate (MTSET); the mutated Cys residue has a free thiol susceptible to reaction with MTSET, and inhibition of current is due to the fact that the residue is close to the selectivity filter.
Ankyrin repeat domain-containing protein 46
>10-fold increase in inhibition of alpha-4-beta-2 nAChR by the conotoxin BuIA.
>10000-fold increase in inhibition of alpha-4-beta-2 nAChR by the conotoxin BuIA.
>1700-fold increase in inhibition of alpha-4-beta-2 nAChR by the conotoxin BuIA.
Neuronal acetylcholine receptor subunit alpha-4
Trafficking protein particle complex subunit 4
Trafficking protein particle complex subunit 13
Loss of substrate cleavage site specificity. Complete loss of cleavage site specificity following an arginine at position P2; when associated with A-195.
Mitochondrial-processing peptidase subunit beta
Severe loss of cleavage site specificity following an arginine at position P2. The loss is complete; when associated with A-191.
Retains proapoptotic activity. Does not heterodimerizes.
Translocon-associated protein subunit gamma
Killer cell lectin-like receptor subfamily I member 1
Guided entry of tail-anchored proteins factor CAMLG
Vacuolar protein sorting-associated protein 45
CDK2-associated and cullin domain-containing protein 1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Transmembrane emp24 domain-containing protein 1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Signal-induced proliferation-associated 1-like protein 2
Increased localization to Golgi apparatus. Has no effect on cell migration.
Inositol 1,4,5-trisphosphate receptor type 2
Sodium- and chloride-dependent GABA transporter 3
Type-1 angiotensin II receptor-associated protein
V-set and immunoglobulin domain-containing protein 1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Colocalized to the lipid droplets with PLIN and ADPR.
Exhibits a diffuse cytoplasmic distribution without colocalization to lipid droplets with PLIN and ADPR. Loss of binding to PLIN.
O-(3'-phospho-DNA)-tyrosine intermediate
Cell cycle exit and neuronal differentiation protein 1
Zinc finger CCCH domain-containing protein 15
Interchain (between alpha and beta subunits)
Gamma-aminobutyric acid receptor subunit beta-3
Cytotoxic and regulatory T-cell molecule
Sorbin and SH3 domain-containing protein 2
Abolishes interaction with CALM1. Decreases interaction with SYT4 and SYT11. Abolishes location to neuronal dense core vesicles.
In isoform 2, isoform 5, isoform 7 and isoform 8.
In isoform 3, isoform 5, isoform 6 and isoform 8.
In isoform 4, isoform 6, isoform 7 and isoform 8.
Reduces decarboxylase activity by 99.8%.
Zinc finger and BTB domain-containing protein 24
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Cation-dependent mannose-6-phosphate receptor
Probable inactive glycosyltransferase 25 family member 3
Potassium voltage-gated channel subfamily H member 1
N-terminal EF-hand calcium-binding protein 1
Extracellular superoxide dismutase [Cu-Zn]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Mediator of RNA polymerase II transcription subunit 22
60S ribosome subunit biogenesis protein NIP7 homolog
Geranylgeranyl transferase type-2 subunit alpha
Does not affect PRAG1-CSK complex formation. Does not affect PRAG1-induced protein tyrosine phosphorylation.
Does not affect cytoplasmic localization.
Strong reduction of homodimerization; Does not affect PRAG1-CSK complex formation. Reduces CSK activation.
Significantly reduced interaction with INCA1; when associated with A-117.
Significantly reduced interaction with INCA1; when associated with A-119.
NLR family CARD domain-containing protein 4
Mothers against decapentaplegic homolog 3
Phosphothreonine; by CDK2, CDK4 and MAPK
Rap guanine nucleotide exchange factor 5
Coiled-coil domain-containing protein 134
Connector enhancer of kinase suppressor of ras 3
Peroxisomal multifunctional enzyme type 2
T-cell immunoglobulin and mucin domain-containing protein 2
Potassium voltage-gated channel subfamily E member 2
RAC-gamma serine/threonine-protein kinase
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
HCH Motif; seals regulatory zinc-binding pocket
Ras association domain-containing protein 9
Cancer-associated gene 1 protein homolog
NAD-dependent protein deacetylase sirtuin-7
Does not abolish the ability to suppress the growth defect of yeast lacking VRP1.
WAS/WASL-interacting protein family member 3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
No effect on transcriptional activation of CSF1R or FCER1A promoter.
contacts bases in the GGAA sequence in the major groove
contacts the phosphate backbone of the GGAA sequence in the minor groove upstream
forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence
Phosphatidylinositol 4-kinase type 2-alpha
Reduces targeting to synaptic vesicles and neurite tips; when associated with A-60.
Reduces targeting to synaptic vesicles and neurite tips; when associated with A-61.
Lactosylceramide alpha-2,3-sialyltransferase
Probable ATP-dependent RNA helicase DDX46
Mitogen-activated protein kinase kinase kinase 12
Cytoplasmic dynein 2 light intermediate chain 1
Golgi-associated RAB2 interactor protein 1A
Eukaryotic initiation factor 4A-III, N-terminally processed
N-acetylalanine; in Eukaryotic initiation factor 4A-III, N-terminally processed
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Solute carrier family 2, facilitated glucose transporter member 7
Structure-specific endonuclease subunit SLX1
Mediator of RNA polymerase II transcription subunit 28
Transitional endoplasmic reticulum ATPase
Phosphatidylethanolamine N-methyltransferase
Volume-regulated anion channel subunit LRRC8A
Abolishes K-395 sumoylation. Enhances K-395 acetylation. Enhances transcriptional activity.
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Target of rapamycin complex subunit LST8
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Abolishes interaction with DLG1, DLG4 and HOMER1.
Heat shock protein 75 kDa, mitochondrial
Abolishes palmitoylation but not membrane-association; when associates with A-30. No effect on glutamate decarboxylase activity; when associated with A-30.
Abolishes palmitoylation but not membrane-association; when associates with A-45. No effect on glutamate decarboxylase activity; when associated with A-45.
No effect on glutamate decarboxylase activity.
N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A
N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A
Lymphocyte antigen 6 complex locus protein G6d
Tumor necrosis factor alpha-induced protein 8-like protein 2
Mitochondrial import inner membrane translocase subunit Tim23
Tyrosine-protein phosphatase non-receptor type 7
Bipartite nuclear localization signal (NLS1)
Nuclear receptor subfamily 4 group A member 2
Sodium/potassium-transporting ATPase subunit alpha-3
Neuronal acetylcholine receptor subunit beta-3
Xin actin-binding repeat-containing protein 2
Synapse differentiation-inducing gene protein 1
2-fold decrease of omega/omega-1 hydroxylation ratio for lauric acid.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
Ribosome biogenesis protein BRX1 homolog
Impairs Gpm6a-induced filopodium formation.
Impairs synaptic density in primary hippocampal neurons; when associated with A-174.
Impairs synaptic density in primary hippocampal neurons; when associated with A-192.
Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-256 and A-267.
Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-256 and A-268.
Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-267 and A-268.
Reduces motility of Gpm6a-induced filopodia; when associated with A-256, A-267 and A-268.
Phosphoserine; by PKB/AKT1, CLK1 and CLK2
Tyrosine-protein phosphatase non-receptor type 1
In isoform D, isoform E, isoform F and isoform H.
Potassium voltage-gated channel subfamily KQT member 2
Omega-N-methylarginine; by PRMT6; alternate
With 1 acetyl, 1 methyl and 2 phosphate groups.
With 1 acetyl, 1 methyl and 3 phosphate groups.
Matrix metalloproteinase-23, soluble form
dolichyl-phosphate-mannose--protein mannosyltransferase
Rho guanine nucleotide exchange factor 7
Cilia- and flagella-associated protein 298
N-alpha-acetyltransferase 25, NatB auxiliary subunit
ATP synthase membrane subunit K, mitochondrial
Large decrease in phosphorylation by SAPK3.
Slight decrease in phosphorylation by SAPK3.
Actin, alpha skeletal muscle, intermediate form
tRNA-uridine aminocarboxypropyltransferase 1
Phosphoserine; by IKKA, IKKB, IKKE and TBK1
Cell growth regulator with RING finger domain protein 1
For beta-hydroxyacyl dehydratase activity
N6-(pyridoxal phosphate)lysine; alternate
O-(pantetheine 4'-phosphoryl)serine; alternate
>1000-fold increase of sensitivity to the conotoxin GVIIJ(SSG).
Little change in voltage-dependence of conductance and decrease in affinity to the sea anemone toxin anthopleurin-B (residue Lys-37).
Sodium channel protein type 5 subunit alpha
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Starch-binding domain-containing protein 1
Methylglutaconyl-CoA hydratase, mitochondrial
Nuclear receptor subfamily 4 group A member 1
Phosphoserine; by PKA, RPS6KA1 and RPS6KA3
Decreases synaptic insertion during chemical-induced long term potentiation.
Phosphoserine; by PKC, PKA and PKG/PRKG2
14-3-3 protein gamma, N-terminally processed
N-acetylvaline; in 14-3-3 protein gamma, N-terminally processed
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Sodium-dependent multivitamin transporter
Interleukin-1 receptor type 2, membrane form
Interleukin-1 receptor type 2, soluble form
Abolishes the inositol deacylation of GPI-anchor proteins.
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Impairs N-glycosylation; when associated with Q-109; Q-116 and Q-122. Significantly decreases taurocholate; when associated with Q-109; Q-116 and Q-122. Significantly decreases protein expression; when associated with Q-109; Q-116 and Q-122. Affects protein localization at the apical membrane;when associated with Q-109; Q-116 and Q-122.
Impairs N-glycosylation; when associated with Q-109; Q-116 and Q-125. Significantly decreases taurocholate; when associated with Q-109; Q-116 and Q-125. Significantly decreases protein expression; when associated with Q-109; Q-116 and Q-125. Affects protein localization at the apical membrane; when associated with Q-109; Q-116 and Q-125.
Impairs N-glycosylation; when associated with Q-109; Q-122 and Q-125. Significantly decreases taurocholate; when associated with Q-109; Q-122 and Q-125. Significantly decreases protein expression; when associated with Q-109; Q-122 and Q-125. Affects protein localization at the apical membrane; when associated with Q-109; Q-122 and Q-125. Does not affect protein localization at the apical membrane; when associated with Q-109; Q-122 and Q-125.
Impairs N-glycosylation; when associated with Q-116; Q-122 and Q-125. Significantly decreases taurocholate; when associated with Q-116; Q-122 and Q-125. Significantly decreases protein expression; when associated with Q-116; Q-122 and Q-125. Affects protein localization at the apical membrane; when associated with Q-116; Q-122 and Q-125. Does not affect protein localization at the apical membrane.
39S ribosomal protein L41, mitochondrial
ADP-ribosylation factor GTPase-activating protein 2
ATP-binding cassette sub-family C member 9
T-cell surface glycoprotein CD3 epsilon chain
Transcription elongation factor A protein-like 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
In isoform 2, isoform ZA, isoform ZB and isoform ZC.
In isoform WA, isoform XA, isoform YA and isoform ZA.
In isoform WB, isoform XB, isoform YB and isoform ZB.
In isoform WC, isoform XC, isoform YC and isoform ZC.
In isoform XA, isoform XB and isoform XC.
In isoform YA, isoform YB and isoform YC.
Plasma membrane calcium-transporting ATPase 2
Protein phosphatase 1 regulatory subunit 14C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Glutamate--cysteine ligase regulatory subunit
T-cell surface glycoprotein CD3 zeta chain
Biogenesis of lysosome-related organelles complex 1 subunit 6
Mitochondrial import inner membrane translocase subunit Tim8 A
Leucine-rich repeat-containing protein 15
Tumor necrosis factor receptor superfamily member 4
Potassium voltage-gated channel subfamily A member 5
Zinc finger Ran-binding domain-containing protein 2
Gamma-aminobutyric acid receptor subunit pi
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Abolishes synergistic action with SOX11.
POU domain, class 3, transcription factor 3
39S ribosomal protein L40, mitochondrial
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Transmembrane emp24 domain-containing protein 2
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Voltage-dependent calcium channel gamma-3 subunit
Guanine nucleotide-binding protein-like 1
No effect on surface expression and channel activity; when associated with Q-407.
No effect on surface expression and channel activity; when associated with Q-414.
Connector enhancer of kinase suppressor of ras 2
Mitochondrial amidoxime reducing component 2
Abolishes ubiquitin ligase activity; when associated with S-169 and C-182.
Abolishes ubiquitin ligase activity; when associated with S-169 and C-184.
Abolishes ubiquitin ligase activity; when associated with S-182 and S-184.
Plasma membrane calcium-transporting ATPase 4
Isocitrate dehydrogenase [NADP] cytoplasmic
No significant effect on interaction with RAB3IP.
Tricarboxylate transport protein, mitochondrial
G-protein coupled receptor-associated sorting protein 1
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-432)
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424)
RNA-binding protein with serine-rich domain 1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1
Reduces ubiquitin binding and Golgi reassembly.
Strongly reduces binding to Golgi membranes.
In isoform Alpha2A, isoform Alpha2B and isoform Alpha2C.
Pro-neuregulin-1, membrane-bound isoform
Cyclic AMP-dependent transcription factor ATF-5
Binds to BoNT/B in the absence of gangliosides.
Fails to relocalize to nerve terminals after stimulation of neurotransmitter release.
Greatly increased binding of fragment 1-53 to C.botulinum type B (BoNT/B, botB) heavy chain; increases its resemblance to Syt2.
Increased binding of fragment 1-53 to BoNT/B heavy chain.
Slightly increased binding of fragment 1-53 to BoNT/B heavy chain.
Slows synaptic vesicle fusion kinetics and exocytosis.
Slows synaptic vesicle fusion kinetics and exocytosis. Impairs the kinetics of synaptic vesicle endocytosis.
Golgi-associated RAB2B interactor protein 3
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Insulin-like growth factor-binding protein 2
Moderate decrease in ligand binding. 200-fold reduction of agonist-mediated cAMP inhibition.
Small decrease in agonist binding. 18-fold reduction of agonist-mediated cAMP inhibition.
Small decrease in agonist binding. Complete loss of agonist-mediated cAMP inhibition.
Cytosolic arginine sensor for mTORC1 subunit 1
Zinc finger CCCH-type with G patch domain-containing protein
Abolishes cleavage and shedding of ectodomain; when associated with A-94.
Abolishes cleavage and shedding of ectodomain; when associated with G-91.
Plasminogen activator inhibitor 2 type A
Abolishes signaling via G-proteins; when associated with A-166 and A-310.
Abolishes signaling via G-proteins; when associated with A-166 and A-358.
Abolishes signaling via G-proteins; when associated with A-310 and A-358.
Voltage-dependent L-type calcium channel subunit beta-3
Trifunctional enzyme subunit beta, mitochondrial
Serine/threonine-protein phosphatase 6 catalytic subunit
Killer cell lectin-like receptor subfamily E member 1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Spermatogenesis-associated protein 19, mitochondrial
Sodium-dependent phosphate transporter 1
Leucine zipper putative tumor suppressor 3
Voltage-dependent L-type calcium channel subunit alpha-1S
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial
Small conductance calcium-activated potassium channel protein 3
Dual specificity mitogen-activated protein kinase kinase 1
Insulin-like growth factor 1 receptor alpha chain
Insulin-like growth factor 1 receptor beta chain
Alanine and arginine-rich domain-containing protein
Glycerophosphodiester phosphodiesterase 1
Strongly reduced activity; when associated with A-97.
Strongly reduced activity; when associated with A-99.
Platelet-activating factor acetylhydrolase IB subunit alpha1
Dipeptidyl peptidase 1 exclusion domain chain
DNA-directed RNA polymerase I subunit RPA2
Impaired ability to regulate alternative splicing of Ttn (Titin) mRNAs. Decreased localization to the nucleus associated with an increased localization to cytoplasmic ribonucleoprotein granules.
Mimics phosphorylation; does not restore nuclear localization.
No effect; does not affect ability to regulate alternative splicing.
Leucine-rich repeat flightless-interacting protein 1
Probable E3 ubiquitin-protein ligase HERC4
Amiloride-sensitive sodium channel subunit beta
Cellular retinoic acid-binding protein 1
Translational activator of cytochrome c oxidase 1
Voltage-dependent calcium channel gamma-8 subunit
Transmembrane emp24 domain-containing protein 7
Leucine-rich repeat-containing protein 66
N-alpha-acetyltransferase 35, NatC auxiliary subunit
ATP-sensitive inward rectifier potassium channel 14
Almost abolishes interaction with IQSEC1; when associated with V-876. Abolishes activation of ARF6 by IQSEC1; when associated with V-876.
Almost abolishes interaction with IQSEC1; when associated with Y-875. Abolishes activation of ARF6 by IQSEC1; when associated with Y-875.
Promotes dimerization. Strongly reduced desensitization.
Strongly decreases interaction with IQSEC1. Abolishes activation of ARF6 by IQSEC1.
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Phosphoserine; by PAK1, PAK2, PAK3 and PAK5
RAF proto-oncogene serine/threonine-protein kinase
Does not affect carbonyl reductase (NADPH) activity.
Serine/threonine-protein kinase PRP4 homolog
C-Jun-amino-terminal kinase-interacting protein 2
Non-POU domain-containing octamer-binding protein
Abolishes interaction with APP and impairs the function in DNA repair.
Amyloid beta precursor protein binding family B member 1
BH3-interacting domain death agonist p11
BH3-interacting domain death agonist p13
BH3-interacting domain death agonist p15
Abolishes Ca(2+)-dependent phospholipid-binding.
TATA box-binding protein-associated factor, RNA polymerase I, subunit C
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Myelin-associated oligodendrocyte basic protein
cAMP-responsive element-binding protein-like 2
In isoform 2, isoform 3, isoform 4, isoform 6, isoform 8 and isoform 9.
Regulating synaptic membrane exocytosis protein 2
In isoform 2, isoform 3, isoform 4 and isoform 5.
Abrogates GTP-binding and nucleolar localization.
Guanine nucleotide-binding protein-like 3
Oxysterol-binding protein-related protein 1
Loss of prenylation and normally targeted to vesicular structures; when associated with A-194. Normally targeted to vesicular structures; when associated with D-8. Normally targeted to vesicular structures; when associated with E-39 and E-42. Normally targeted to vesicular structures; when associated with E-50 and E-56.
Loss of prenylation and normally targeted to vesicular structures; when associated with A-195. Normally targeted to vesicular structures; when associated with D-8.
Mistargeted to Golgi and plasma membrane.
Mistargeted to Golgi and plasma membrane. Normally targeted to vesicular structures; when associated with A-194 or A-195.
Mistargeted to Golgi and plasma membrane; when associated with E-39. Normally targeted to vesicular structures; when associated with E-39 and A-195.
Mistargeted to Golgi and plasma membrane; when associated with E-42. Normally targeted to vesicular structures; when associated with E-42 and A-195.
Mistargeted to Golgi and plasma membrane; when associated with E-50. Normally targeted to vesicular structures; when associated with E-50 and A-195.
Mistargeted to Golgi and plasma membrane; when associated with E-56. Normally targeted to vesicular structures; when associated with E-56 and A-195.
Phosphatidylcholine:ceramide cholinephosphotransferase 2
ADP-ribosylation factor-related protein 1
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Coiled-coil domain-containing protein 89
3-hydroxyisobutyrate dehydrogenase, mitochondrial
Decrease of activity with NAD, increase of activity with NADP.
HIG1 domain family member 1A, mitochondrial
SNF-related serine/threonine-protein kinase
Protein-glutamine gamma-glutamyltransferase K
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Zinc finger and BTB domain-containing protein 4
Phosphatidylinositol-glycan biosynthesis class X protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Chloride intracellular channel protein 2
Cleavage and polyadenylation specificity factor subunit 7
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Fails to dissociate from KEAP1 after PKC activation.
Nuclear factor erythroid 2-related factor 2
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Pancreas transcription factor 1 subunit alpha
Jupiter microtubule associated homolog 2
Cation channel sperm-associated protein 2
Schiff-base intermediate with DNA; for 5'- deoxyribose-5-phosphate lyase activity
Transcription elongation factor A N-terminal and central domain-containing protein 2
Leucine-rich repeat transmembrane neuronal protein 3
In allele Aldh2*2 and allele Aldh2*3; in strains UChA and UChB.
Cysteinyl-selenocysteine (Cys-Sec); redox-active
With bound glutathione and undetermined modification.
Without bound glutathione or undetermined modification.
Complement C1q tumor necrosis factor-related protein 6
Receptor-type tyrosine-protein phosphatase R
Abolishes phospholipase activity, but does not impair lipid binding.
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aspartate aminotransferase, mitochondrial
Abolishes myristoylation and palmitoylation.
Expected to have lost GTPase activity; inhibits the forskolin-mediated increase of cellular cAMP levels. Does not inhibit interaction with RGS14 at centrosomes.
Guanine nucleotide-binding protein G(i) subunit alpha-1
Increases basal GDP exchange rate and inhibits the forskolin-mediated increase of cellular cAMP levels.
Increases basal GDP exchange rate; mildly decreases receptor-stimulated GDP exchange.
Increases basal GDP exchange rate; no effect on receptor-stimulated GDP exchange.
Inhibits interaction with RGS14. Does not inhibit interaction with RIC8A.
Mildly impairs receptor binding; mildly decreases basal and receptor-stimulated GDP exchange.
No effect on basal GDP exchange rate; mildly decreases receptor-stimulated GDP exchange.
Strongly increases basal GDP exchange rate; mildly decreases receptor-stimulated GDP exchange.
Cytochrome b-c1 complex subunit 1, mitochondrial
Abolishes regulation of calcium mobilization.
Highly reduces thioredoxin reductase activity.
Thioredoxin reductase-like selenoprotein T
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Cytochrome c oxidase subunit 7A2, mitochondrial
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Serine/threonine-protein kinase 3 20kDa subunit
Serine/threonine-protein kinase 3 36kDa subunit
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Decreased methylation. Does not affect subcellular location.
Heterogeneous nuclear ribonucleoproteins A2/B1
Strongly reduces binding to PtdIns(3,5)P2.
Greatly reduces plasma membrane localization.
Nuclear protein localization protein 4 homolog
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
In TFM; has only 10-15% of the androgen-binding capacity of wild-type AR.
Abolishes the phosphoric diester hydrolase activity against PAF.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Potassium voltage-gated channel subfamily KQT member 1
Electrogenic sodium bicarbonate cotransporter 1
No effect on N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-597 and Q-617.
Reduces the extent of N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-592 and Q-597.
Reduces the extent of N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-592 and Q-617.
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Eukaryotic translation initiation factor 2-alpha kinase 3
Abolishes O-glycosylation and localization at the cell surface; when associated with A-44 and A-77.
Abolishes O-glycosylation and localization at the cell surface; when associated with A-44; A-50; A-51; A-52; A-56; A-57; A-58; A-60; A-61; A-62; A-63; A-65; A-76; A-68; A-69 and A-71.
Abolishes O-glycosylation and localization at the cell surface; when associated with A-50; A-51; A-52; A-56; A-57; A-58; A-60; A-61; A-62; A-63; A-65; A-76; A-68; A-69; A-71 and A-77.
Alkaline phosphatase, tissue-nonspecific isozyme
Inhibits ability to activate VEGFR-2 and VEGFR-3.
Breast cancer anti-estrogen resistance protein 3 homolog
Rho guanine nucleotide exchange factor 11
Abolishes L-glutamine transport activity. Induces a chloride transport. Increases the alkali-induced substrate-independent conductance. Does not affect cell membrane localization.
Abolishes L-glutamine transport activity. Inhibits asparagine transport activity. Increases the alkali-induced substrate-independent conductance. Significantly slow proton antiport activity. Affects cell membrane localization.
Abolishes glutamine transport activity. Increases the alkali-induced substrate-independent conductance. Does not affect cell membrane localization.
Abolishes glutamine transport activity.Increases the alkali-induced substrate-independent conductance. Does not affect cell membrane localization.
Does not affect L-glutamine transport activity. Does not affect cell membrane localization.
Loss of phosphorylation by PKC. Reduces glutamine uptake upon phorbol-12-myristate-13-acetate (PMA) stimulation.
Significantly decreases L-glutamine transport activity. Does not affect cell membrane localization. Removes the cation conductance at pH 7.4. Does not affect the proton conductance at pH 8.4. Significantly dereases transport activity with LiCl.
Sodium-coupled neutral amino acid transporter 3
N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternate
N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; partial
Peptidyl-prolyl cis-trans isomerase FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
Nuclear transcription factor Y subunit beta
Transcription initiation factor TFIID subunit 9B
NPC intracellular cholesterol transporter 2
Aryl-hydrocarbon-interacting protein-like 1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
Decreases interaction with ATG14, no effect on interaction with UVRAG; when associated with L-189, L-217 and L-224.
Decreases interaction with ATG14, no effect on interaction with UVRAG; when associated with L-189, L-217 and L-255.
Decreases interaction with ATG14, no effect on interaction with UVRAG; when associated with L-189, L-224 and L-255.
Decreases interaction with ATG14, no effect on interaction with UVRAG; when associated with L-217, L-224 and L-255.
Disrupts homodimerization, no effect on interaction with ATG14 and UVRAG; when associated with A-178.
Disrupts homodimerization, no effect on interaction with ATG14 and UVRAG; when associated with A-192.
Disrupts homodimerization, no effect on interaction with ATG14 and UVRAG; when associated with A-196.
Disrupts homodimerization, no effect on interaction with ATG14 and UVRAG; when associated with A-259.
Abolishes homooligomerization; when associated with A-67.
No effect on interaction with PRKCI. Abolishes homooligomerization; when associated with A-67.
von Willebrand factor A domain-containing protein 7
Dual serine/threonine and tyrosine protein kinase
Gamma-interferon-inducible lysosomal thiol reductase
Constitively active mutant. Does not affect interaction with APBB1/FE65.
Dexamethasone-induced Ras-related protein 1
No effect on myosin incorporation into sarcomeres.
No effect on myosin incorporation into sarcomeres. Causes myosin cytoplasmic aggregates that show a sponge-like structure.
No effect on myosin incorporation into sarcomeres. Disrupts location on the sarcomere bare zone.
BMP/retinoic acid-inducible neural-specific protein 3
Coiled-coil domain-containing protein 181
Membrane-associated phosphatidylinositol transfer protein 1
4-trimethylaminobutyraldehyde dehydrogenase
Heterogeneous nuclear ribonucleoprotein D0
Phosphoribosyl pyrophosphate synthase-associated protein 2
EARP and GARP complex-interacting protein 1
Cocaine is effective at blocking transport.
Microsomal triglyceride transfer protein large subunit
Causes dissociation from promyelocytic leukemia oncogenic bodies and increased blebbing-inducing potency; when associated with T-299.
Causes dissociation from promyelocytic leukemia oncogenic bodies and increased blebbing-inducing potency; when associated with T-300.
Loss of kinase activity, loss of PAWR-linked translocation into the cytoplasm; maintains nuclear localization but loss of localization to PML-NB.
Phosphoserine; by autocatalysis and DAPK1
UDP-glucose:glycoprotein glucosyltransferase 1
Voltage-dependent L-type calcium channel subunit alpha-1C
Phytanoyl-CoA dioxygenase domain-containing protein 1
Disintegrin and metalloproteinase domain-containing protein 17
Proline-, glutamic acid- and leucine-rich protein 1
Induces partial mitochondria fragmentation; when overexpressed.
Peroxisome proliferator-activated receptor alpha
cAMP-dependent protein kinase inhibitor alpha
28S ribosomal protein S10, mitochondrial
IxM motif; signal for cargo packaging into COPII-coated vesicles
In isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12.
In isoform 3, isoform 4, isoform 9 and isoform 10.
In isoform 5, isoform 6, isoform 11 and isoform 12.
In isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
5'-AMP-activated protein kinase subunit beta-2
PX domain-containing protein kinase-like protein
Neuronal acetylcholine receptor subunit beta-4
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Abolishes binding to and activation of GNAI3.
Abolishes binding to and activation of GNAI3; when associated with A-315.
Abolishes binding to and activation of GNAI3; when associated with A-319.
Electron transfer flavoprotein subunit beta
N6,N6,N6-trimethyllysine; by ETFBKMT; alternate
Glutamate receptor-interacting protein 1
C5a anaphylatoxin chemotactic receptor 2
Sodium- and chloride-dependent glycine transporter 1
WAS/WASL-interacting protein family member 1
PH domain leucine-rich repeat protein phosphatase 1
Magnesium transporter MRS2 homolog, mitochondrial
ATP-dependent 6-phosphofructokinase, muscle type
28S ribosomal protein S31, mitochondrial
Proto-oncogene tyrosine-protein kinase LCK
Histo-blood group ABO system transferase 1
N6-acetyllysine; by KAT2A and KAT2B; alternate
No effect on DNA-binding. Increases transactivation activity.
No effect on DNA-binding. Loss of transactivation activity. Loss of hepatocyte proliferation induction by TGFA.
Phosphothreonine; by RPS6KA1, CDK2 and MAPK
17-fold increase in affinity for oxytocin. No change in affinity for arginine vasopressin or 1-deamino, D-Arg8-vasopressin.
50-fold decrease in affinity for arginine vasopressin. Little affect on affinity for oxytocin or 1-deamino, D-Arg8-vasopressin.
No significant change in affinity for arginine vasopressin or oxytocin. Increased affinity for 1-deamino, D-Arg8-vasopressin.
Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-371.
Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-372.
Cleavage and polyadenylation specificity factor subunit 5
Vacuolar protein sorting-associated protein 52 homolog
Solute carrier family 52, riboflavin transporter, member 3
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ubiquitin carboxyl-terminal hydrolase BAP1
Pleckstrin homology domain-containing family H member 3
SH3 domain-containing YSC84-like protein 1
Sodium-dependent neutral amino acid transporter B(0)AT2
Filamin 20; mediates interaction with XIRP1
Complex I assembly factor TMEM126B, mitochondrial
Kelch repeat and BTB domain-containing protein 8
Abolishes phosphorylation, leading to degradation by the proteasome.
Afadin- and alpha-actinin-binding protein
Abolishes inhibition by phosphorylation.
No current (homomultimers); one fourth of the WT current (heteromultimers).
Potassium voltage-gated channel subfamily E member 1
Adaptin ear-binding coat-associated protein 1
Induces a strong decrease in activity; loss of function; when associated with A-484 and A-525.
Loss of enzyme activity due to absence of interaction between UDP moiety and UDP-GalNAC.
Loss of enzyme activity; when associated with A-444 and A-484.
Loss of enzyme activity; when associated with A-444 and A-525.
Polypeptide N-acetylgalactosaminyltransferase 1
Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
Myelin transcription factor 1-like protein
Large neutral amino acids transporter small subunit 1
ADP-ribosylation factor-like protein 13A
Ubiquitin-like modifier-activating enzyme ATG7
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Abolishes mitotic phosphorylation. Reduced mitotic mitochondrial fragmentation.
Defective in GTP hydrolysis. Tubulates spherical liposomes. Impairs mitochondrial division. Decreases the BCL2L1-mediated induction of synapse number and size of synaptic vesicle clusters.
Growth arrest and DNA damage-inducible protein GADD45 gamma
Mitochondrial 2-oxodicarboxylate carrier
Disintegrin and metalloproteinase domain-containing protein 5
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
CCR4-NOT transcription complex subunit 11
Dipeptidyl peptidase 4 60 kDa soluble form
Nuclear envelope pore membrane protein POM 121
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
5-aminolevulinate synthase, non-specific, mitochondrial
Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranes
Signal peptidase complex catalytic subunit SEC11C
No effect on protein expression and transport activity.
No effect on protein expression and transport activity. Reduced protein expression and loss of transport activity; when associated with S-306.
No effect on protein expression but reduced transport activity.
No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-225 or S-520. No effect on protein expression and reduced transport activity; when associated with S-334.
No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-225. No effect on protein expression and reduced transport activity; when associated with S-306.
No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-306 or S-334.
Reduced protein expression and transport activity.
Sodium-dependent phosphate transport protein 2A
Alters subunit assembly via domain swapping and reduces channel activity.
Prevents up-regulation of the channel by phosphorylation; when associated with F-201.
Prevents up-regulation of the channel by phosphorylation; when associated with F-202.
Transient receptor potential cation channel subfamily V member 6
Serine/threonine-protein kinase 24 12 kDa subunit
Serine/threonine-protein kinase 24 35 kDa subunit
Mitochondrial intermembrane space import and assembly protein 40
Abolishes inhibition of neurite outgrowth from CNS neurons.
No effect on inhibition of neurite outgrowth from sensory neurons.
Cyclic nucleotide-gated cation channel alpha-4
Translocating chain-associated membrane protein 1
C-type lectin domain family 2 member D11
Spermatogenesis associated 6-like protein
Brain and acute leukemia cytoplasmic protein
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
VPS35 endosomal protein-sorting factor-like
Tumor necrosis factor receptor superfamily member 8
Phospholipid phosphatase-related protein type 1
ATP-binding cassette sub-family F member 3
Acyl-coenzyme A synthetase ACSM3, mitochondrial
Hyaluronan and proteoglycan link protein 1
Transcription factor IIIB 50 kDa subunit
Pulmonary surfactant-associated protein D
Abolishes phosphorylation by MAPK, increases functional activity and enhances retention in peripheral membranes; when associated with 1476-A--A-1483.
Abolishes phosphorylation by MAPK, increases functional activity and enhances retention in peripheral membranes; when associated with A-1451.
Disrupts GTP-binding. No direct effect on GAP activity 'in vitro' but affects the activity regulation 'in vivo'.
Rate of phosphorylation by an insect Pink1 is increased.
Rate of phosphorylation by an insect Pink1 is slightly decreased.
Rate of phosphorylation by an insect Pink1 is very slightly increased.
ATP-binding cassette sub-family C member 12
Protein phosphatase 1 regulatory subunit 15A
Ubiquitin-fold modifier-conjugating enzyme 1
cAMP-dependent protein kinase catalytic subunit beta
Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog
dolichyl-phosphate beta-glucosyltransferase
Prostate and testis expressed protein 14
Potassium voltage-gated channel subfamily D member 3
Phosphatidylinositol-glycan-specific phospholipase D
EGF domain-specific O-linked N-acetylglucosamine transferase
Ankyrin repeat and LEM domain-containing protein 2
GTP-binding nuclear protein Ran, testis-specific isoform
Vacuolar protein sorting-associated protein 26A
Reduces catalytic activity about 30-fold. Reduces affinity for glutathione about 4-fold.
ATP-sensitive inward rectifier potassium channel 8
Ubiquitin-associated domain-containing protein 1
Cullin-associated NEDD8-dissociated protein 1
TRAF-interacting protein with FHA domain-containing protein B
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
Glandular kallikrein-7, submandibular/renal
Coiled-coil domain-containing protein 63
Hepatitis A virus cellular receptor 2 homolog
Growth hormone secretagogue receptor type 1
Abolishes autoinhibition, leading to constitutive kinase activation.
Abolishes interaction with CDC42, leading to strongly decreased activity; when associated with L-83. Reduces NMDA receptor-mediated synaptic currents; when associated with L-83 and R-299.
Abolishes interaction with CDC42, leading to strongly decreased activity; when associated with L-86. Reduces NMDA receptor-mediated synaptic currents; when associated with L-86 and R-299.
Decreases activity; when associated with A-144.
Decreases activity; when associated with A-149.
Inhibits activation by binding to CDC42.
Phosphothreonine; by autocatalysis, BRSK2 and PDPK1
Reduces NMDA receptor-mediated synaptic currents; when associated with L-83 and L-86.
Protein phosphatase 1 regulatory subunit 1B
Spermatogenesis-defective protein 39 homolog
Cyclic AMP-responsive element-binding protein 3-like protein 3
Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Transcription initiation factor TFIID subunit 11
Probable proton-coupled zinc antiporter SLC30A3
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Serine-threonine kinase receptor-associated protein
Volume-regulated anion channel subunit LRRC8C
Integrin-linked kinase-associated serine/threonine phosphatase 2C
DNA-directed RNA polymerase III subunit RPC3
Monocyte to macrophage differentiation factor
Phosphoserine; by autocatalysis and PKC/PRKCD
Platelet-activating factor acetylhydrolase IB subunit alpha2
Charge relay system; for autoendoproteolytic cleavage activity
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
PHD and RING finger domain-containing protein 1
Phenylalanine--tRNA ligase, mitochondrial
In strain: Milan normotensive and FHH hypertensive; no constriction of afferent arterioles in response to increased pressure and impaired renal blood flow autoregulation resulting in kidney disease in both strains; redistributes from the cell membrane to perinuclear location and disrupts the F-actin cytoskeleton in the kidney and renal vascular smooth muscle cells of FHH; elevated membrane expression of the iberiotoxin-sensitive potassium channel alpha and elevated iberiotoxin-sensitive potassium channel current in renal vascular smooth muscle cells of FHH; proteinuria, renal interstitial fibrosis, alterations in gromelural capillary pressure, increased permeability to albumin and impaired glomerular function in FHH after induction of hypertension.
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Actin, alpha cardiac muscle 1, intermediate form
BAG family molecular chaperone regulator 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Translation initiation factor eIF-2B subunit delta
Dominant negative mutant; abolishes ERG current.
Potassium voltage-gated channel subfamily H member 2
Microtubule-associated protein RP/EB family member 2
Probable mitochondrial glutathione transporter SLC25A39
Interferon-induced transmembrane protein 3
Mitogen-activated protein kinase kinase kinase 10
Phosphoserine; by autocatalysis and MAP4K1
Probable inactive ribonuclease-like protein 13
Mas-related G-protein coupled receptor member D
28S ribosomal protein L42, mitochondrial
Uncharacterized protein C6orf136 homolog
CREB-regulated transcription coactivator 2
Phosphoserine; by AMPK, MARK2, SIK1 and SIK2
Abolishes ability to regulate sodium/potassium-transporting ATPase activity following increases in intracellular sodium.
Loss of inhibition of clathrin-mediated and bulk endocytosis.
Restores Ca(2+)-binding and Ca(2+)-dependent phospholipid binding.
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
WD repeat domain phosphoinositide-interacting protein 2
Vasoactive intestinal polypeptide receptor 1
Anaphase-promoting complex subunit CDC26
Mitochondrial import inner membrane translocase subunit Tim10 B
Calcium/calmodulin-dependent protein kinase type IV
Increases Ca(2+)/calmodulin-independent activity.
Loss of kinase activity; confers cytoplasmic localization.
Loss of kinase activity; confers nuclear localization.
No decrease in Ca(2+)/calmodulin-dependent activity after activation by CaMKKs.
Thioredoxin-related transmembrane protein 2
N-linked (GlcNAc...) (complex) asparagine; alternate
N-linked (GlcNAc...) (high mannose) asparagine; in brain; alternate
N-linked (GlcNAc...) (hybrid) asparagine; in brain; alternate
N-linked (GlcNAc...) asparagine; alternate
Uracil nucleotide/cysteinyl leukotriene receptor
Human immunodeficiency virus type I enhancer-binding protein 2 homolog
Uncharacterized protein C11orf87 homolog
Tyrosine-protein phosphatase non-receptor type 6
Abolishes targeting to the basolateral plasma membrane.
Dopamine fails to increase phosphoinositide-3 kinase activity and to promote its interaction with Na(+)/K(+) ATPase.
Results in altered sodium and potassium transport.
Sodium/potassium-transporting ATPase subunit alpha-1
Long-chain fatty acid transport protein 5
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
Actin-related protein 2/3 complex subunit 5-like protein
FXYD domain-containing ion transport regulator 7
50% decrease in agonist-stimulated phosphorylation.
Promotes agonist-independent phosphorylation.
Small decrease in agonist-stimulated phosphorylation.
Strong decrease in agonist-stimulated phosphorylation.
FXYD domain-containing ion transport regulator 4
Choline-phosphate cytidylyltransferase A
Nearly abolishes enzyme activity. Decreases affinity for phosphocholine about 500-fold.
Nearly abolishes enzyme activity. Decreases affinity for phosphocholine about 80-fold.
No loss of enzyme activity and nuclear localization.
Reduced catalytic activity. Reduces affinity for phosphocholine.
Molybdopterin synthase catalytic subunit
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Inhibits incorporation into the PP2A holoenzyme complex and proapoptotic activity.
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Shifts the 4OH E2:2OH E2 hydroxylation ratio from 0.38 to 1.8. Has the 4OH-hydroxylation specificity of the human enzyme.
Hereditary hemochromatosis protein homolog
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
TATA box-binding protein-associated factor RNA polymerase I subunit D
Zinc-regulated GTPase metalloprotein activator 1
Tyrosine-protein phosphatase non-receptor type 9
Bactericidal permeability-increasing protein
NPC1-like intracellular cholesterol transporter 1
Decrease in PLA2, lysophospholipase and lipase activities.
Impairs PLA2, lysophospholipase and lipase activities.
Loss of PLA2, lysophospholipase and lipase activities.
No effect on lysophospholipase to PLA2 activity ratio.
TOX high mobility group box family member 2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Isochorismatase domain-containing protein 2
Methionine adenosyltransferase 2 subunit beta
Nuclear receptor subfamily 5 group A member 2
ATP synthase F(0) complex subunit C2, mitochondrial
FXYD domain-containing ion transport regulator 3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form
Probable ATP-dependent RNA helicase DDX59
Strongly reduces interaction with RAB3A and modulation of exocytosis.
Increased interaction with RAB3A or VAMP2, Golgi condensation.
Retained in endoplasmic reticulum, Golgi and tubular structures, no interaction with RAB3A.
Retained in endoplasmic reticulum, no interaction with RAB3A or VAMP2.
Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and R-992.
Converts the enzyme to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
Slows the conversion from the dehydrogenase form to the oxidase form; when associated with A-535. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and S-1316.
Slows the conversion from the dehydrogenase form to the oxidase form; when associated with R-992. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with R-992 and S-1316.
ATP-binding cassette sub-family C member 2
Capping protein, Arp2/3 and myosin-I linker protein 3
Cysteine sulfonic acid (-SO3H); alternate
Phytanoyl-CoA hydroxylase-interacting protein
Mitochondrial proton/calcium exchanger protein
Alpha- and gamma-adaptin-binding protein p34
Partial relocalization to Golgi membranes.
Cyclic AMP-responsive element-binding protein 3-like protein 1
Processed cyclic AMP-responsive element-binding protein 3-like protein 1
Tumor necrosis factor receptor superfamily member 1B
Nuclear receptor subfamily 2 group F member 6
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Testis-specific protein 10-interacting protein
ATP-binding cassette sub-family D member 2
Loss of transcriptional repressor activity. Loss of interaction with TRIM28.
Cilia- and flagella-associated protein 119
Acid sphingomyelinase-like phosphodiesterase 3a
Cadherin EGF LAG seven-pass G-type receptor 3
Decreased localization to the cell membrane. Decreased interaction with DLG3 and DLG4. No effect on glutamate-gated calcium ion channel activity.
No effect on localizationto the cell membrane. Decreased interaction with DLG3 and DLG4. No effect on glutamate-gated calcium ion channel activity.
Translocon-associated protein subunit alpha
Serine/threonine-protein kinase MRCK alpha
Transforming growth factor-beta-induced protein ig-h3
100-fold decrease binding affinity for GMP as substrate.
100-fold increase in Km and 170-fold decrease in catalytic efficiency for dGMP as substrate.
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Voltage-dependent calcium channel gamma-1 subunit
Small nuclear ribonucleoprotein-associated protein N
Latent-transforming growth factor beta-binding protein 2
Schiff-base intermediate with acetaldehyde
17-beta-hydroxysteroid dehydrogenase type 3
LYR motif; required for interaction with HSC20
Probable cytosolic iron-sulfur protein assembly protein CIAO1
Helical; Voltage-sensor; Name=S4 of repeat I
Helical; Voltage-sensor; Name=S4 of repeat II
Helical; Voltage-sensor; Name=S4 of repeat III
Helical; Voltage-sensor; Name=S4 of repeat IV
Sodium channel protein type 10 subunit alpha
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Biogenesis of lysosome-related organelles complex 1 subunit 5
Cellular retinoic acid-binding protein 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Abolishes phosphorylation and inhibits ADRB2 endocytosis; no effect on interaction with ADRB2.
Impairs interaction with SRC; impairs ADRB2- and HTR1A-mediated ERK phosphorylation; no effect on sequestration of ADRB2; when associated with E-121.
Impairs interaction with SRC; impairs ADRB2- and HTR1A-mediated ERK phosphorylation; no effect on sequestration of ADRB2; when associated with G-91.
Impairs interaction with SRC; impairs ADRB2-mediated ERK phosphorylation and IGFR1-mediated MAP kinase phosphorylation of GAB1; impairs sequestration of ADRB2 and IGFR1; abolishes interaction with clathrin; no effect on interaction with ADRB2 and IGFR1.
Inhibits internalization of EDNRA, EDNRB and ADRB2. No effect on interaction with SRC; impairs ADRB2- and HTR1A-mediated ERK phosphorylation; impairs sequestration of ADRB2.
Abolished interaction with PEX5, leading to impaired peroxisomal import of proteins.
Killer cell lectin-like receptor subfamily G member 1
Solute carrier organic anion transporter family member 1C1
Ubiquitin carboxyl-terminal hydrolase 48
RanBP-type and C3HC4-type zinc finger-containing protein 1
Impairs membrane tubulation and suppression of neurite elongation.
Phosphothreonine; by ROCK2 and PKC/PRKCI
Sodium-dependent neutral amino acid transporter SLC6A17
Zinc finger CCCH domain-containing protein 14
ATP-binding cassette sub-family G member 8
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Alters secondary structure and lowers activity.
Transmembrane protease serine 11B-like protein
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
m-AAA protease-interacting protein 1, mitochondrial
Nucleoside diphosphate-linked moiety X motif 6
[DE]RFG motif; may stabilize a conformation that preferentially activates signaling via beta-arrestin family members
cAMP-dependent protein kinase type II-beta regulatory subunit
Thyroid hormone receptor-associated protein 3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Interchain (between alpha-2-2 and delta-2 chains)
Voltage-dependent calcium channel subunit alpha-2-2
Voltage-dependent calcium channel subunit alpha-2/delta-2
Voltage-dependent calcium channel subunit delta-2
Coiled-coil domain-containing protein 33
Coiled-coil domain-containing protein 39
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Become sensitive to the spider beta/delta-theraphotoxin-Pre1a, which inhibits inactivation of the channel.
In strain: COP; prostatic cancer cell lines.
No change in sensitivity to the spider beta/delta-theraphotoxin-Pre1a.
Sodium channel protein type 4 subunit alpha
Strongly reduced sensitivity to saxitoxin.
Strongly reduced sensitivity to tetrodotoxin.
Mitogen-activated protein kinase kinase kinase kinase 3
Actin filament-associated protein 1-like 1
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
STE20-like serine/threonine-protein kinase
Loss of glycine transport. Retained in the endoplasmic reticulum due to defective processing and trafficking to the cell surface.
Sodium- and chloride-dependent glycine transporter 2
Loss of TSH-increased inositol phosphate, but not cAMP formation.
Endoplasmic reticulum membrane-associated RNA degradation protein
Consistently high basal adenylate cyclase activity; when associated with A-1196. Does not affect calmodulin binding; when associated with A-1196.
Consistently high basal adenylate cyclase activity; when associated with A-1200. Does not affect calmodulin binding; when associated with A-1200.
Decraeses significantly the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Does not affect adenylate cyclase activity in response to calcium in vitro. Reduces adenylate cyclase activity in response to capacitative calcium entry (CCE). Reduces colocalization with actin. Does not improve the distribution of the actin cytoskeleton at the plasma membrane.
Does not affect calcium activated adenylate cyclase.
Does not affect calcium activated adenylate cyclase. Does not affect calmodulin binding.
Does not affect calcium activated adenylate cyclase. Increases slightly basal adenylate cyclase activity but not significantly, and retains an appreciable calcium regulation. Significant high basal adenylate cyclase activity; when associated with N-1197.
Does not affect calcium activated adenylate cyclase. Significant high basal adenylate cyclase activity. Significant high basal adenylate cyclase activity; when associated with Q-1202.
Does not affect calcium activated adenylate cyclase; when associated with A-1197 and A-1198. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1197 and A-1198. Has an elevated basal activity; when associated with A-1197 and A-1198. Does not affect calmodulin binding; when associated with A-1197 and A-1198.
Does not affect calcium activated adenylate cyclase; when associated with A-1197. Does not affect calcium activated adenylate cyclase; when associated with A-1197 and A-1202. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1197 and A-1202. Has an elevated basal activity; when associated with A-1197. Has an elevated basal activity; when associated with A-1197 and A-1202. Does not affect calmodulin binding; when associated with A-1197. Does not affect calmodulin binding; when associated with A-1197 and A-1202.
Does not affect calcium activated adenylate cyclase; when associated with A-1198. Does not affect calcium activated adenylate cyclase; when associated with A-1198 and A-1202.Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1198 and A-1202. Has an elevated basal activity; when associated with A-1198. Has an elevated basal activity; when associated with A-1198 and A-1202. Does not affect calmodulin binding; when associated with A-1198. Does not affect calmodulin binding; when associated with A-1198 and A-1202.
Does not affect calcium activated adenylate cyclase; when associated with E-1202. Greatly diminishes calmodulin binding; when associated with E-1202.
Does not affect calcium activated adenylate cyclase; when associated with E-1204. Greatly diminishes calmodulin binding; when associated with E-1204.
Does not affect calcium activated adenylate cyclase; when associated with E-1208. Does not affect calmodulin binding; when associated with E-1208.
Does not affect calcium activated adenylate cyclase; when associated with E-1209. Does not affect calmodulin binding; when associated with E-1209.
Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-814 and A-818. Affects membrane raft localization; when associated with Q-814 and A-818. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-814 and A-818.
Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-814 and A-885. Affects membrane raft localization; when associated with Q-814 and A-885. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-814 and A-885.
Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-818 and A-885. Affects membrane raft localization; when associated with Q-818 and A-885. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-818 and A-885.
Does not affect dimerization. Does not affect dimerization;when associated with A-432. Does not affect dimerization;when associated with A-446 and A-432. Does not affect dimerization;when associated with A-432; A-446 and A-453. Dramatically reduces the levels of the N-glycosylated monomeric species. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-432.Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-446 and A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-453; A-432 and A-446. Loss of calcium- and calmodulin-responsive adenylate cyclase activity. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-446 and A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-453; A-432 and A-446. Affects membrane raft localization. Affects membrane raft localization; when associated with A-432. Affects membrane raft localization; when associated with A-446 and A-432. Affects membrane raft localization; when associated with A-439; A-432 and A-446.
Does not affect dimerization; when associated with A-439 and A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439 and A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439 and A-432. Affects membrane raft localization; when associated with A-439 and A-432.
Does not affect dimerization; when associated with A-439. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439. Affects membrane raft localization; when associated with A-439.
Does not affect dimerization; when associated with A-439; A-432 and A-446. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439; A-432 and A-446. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439; A-432 and A-446. Affects membrane raft localization; when associated with A-439; A-432 and A-446.
Does not affect the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Does not affect the stimulatoty effect of PKA inhibitoron calcium-stimulated adenylate cyclase activity.
Does not interacts with CALM1; when associated with 38-A--A-40. Interacts with PPP2CA; when associated with 38-A--A-40. Greatly reduces CCE-stimulated adenylate cyclase activity; when associated with 38-A--A-40. Does not affect caveolar localization; when associated with 38-A--A-40.Does not affect calcium/calmodulin stimulated adenylate cyclase activity; when associated with 38-A--A-40. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 38-A--A-40; A-1197; A-1198 and A-1202.
Does not interacts with CALM1; when associated with 49-A--A-51. Interacts with PPP2CA; when associated with 49-A--A-51. Greatly reduces CCE-stimulated adenylate cyclase activity; when associated with 49-A--A-51. Does not affect caveolar localization; when associated with 49-A--A-51. Does not affect calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; A-1197; A-1198 and A-1202.
Increased CCE-stimulated adenylate cyclase activity. Has a high basal activity.
Insensitive to the stimulatory effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Loses adenylate cyclase activity in response to calcium.
Loses the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Ubiquitin carboxyl-terminal hydrolase 16
PWWP domain-containing DNA repair factor 3A
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
Sodium-coupled neutral amino acid transporter 4
Ankyrin repeat domain-containing protein 54
Decreases nuclear expression; when associated with A-104 and A-108.
Decreases nuclear expression; when associated with A-104 and A-109.
Decreases nuclear expression; when associated with A-108 and A-109.
Enhances nuclear expression; when associated with A-66 and A-67.
Enhances nuclear expression; when associated with A-66 and A-70.
Enhances nuclear expression; when associated with A-67 and A-70.
Vesicle-associated membrane protein-associated protein B
Cell division cycle-associated 7-like protein
Calcium permeable stress-gated cation channel 1
Abolishes protein phosphatase 1 binding.
RBPJ-interacting and tubulin-associated protein 1
Histone-lysine N-methyltransferase KMT5B
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)
Transmembrane emp24 domain-containing protein 5
Processed zona pellucida sperm-binding protein 1
Leucine-rich repeat-containing protein 41
Post-GPI attachment to proteins factor 3
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processed
WD40 repeat-containing protein SMU1, N-terminally processed
Potassium voltage-gated channel subfamily H member 8
Abolishes interaction with TTGN1 and EGFR.
Inhibits endocytosis by AP-2; no effect on membrane association of AP-2.
Actin-related protein 2/3 complex subunit 5
Transforming growth factor beta regulator 1
High affinity immunoglobulin epsilon receptor subunit gamma
CREB-regulated transcription coactivator 1
Discoidin, CUB and LCCL domain-containing protein 2
Gamma-aminobutyric acid receptor subunit rho-2
Myeloid differentiation primary response protein MyD88
Loss of EP300-mediated transcriptional coactivation.
Loss of transcriptional activity. Loss of DNA-binding. Altered localization to the nucleus.
Loss of transcriptional activity. No effect on DNA-binding. Loss of homodimerization. Altered localization to the nucleus.
Retinoic acid receptor responder protein 2
No internalization nor down-regulation. No effect on transcriptional signaling.
Uncharacterized protein C19orf44 homolog
Coiled-coil domain-containing protein 153
Decreased activity for acidic amino acids at position P3, whereas the activity against basic amino is increased.
Decreased secretion without affecting the protease activity.
Reduced affinity for DCC. Strongly reduced affinity for DCC; when associated with A-117.
Reduced affinity for DCC. Strongly reduced affinity for DCC; when associated with A-123.
Generates currents that resembles wild-type in terms of voltage dependence and kinetic behavior but has 2- to 3-fold higher amplitude compared to wild-type. The mutation shows to cause constitutive activation of the channel, mimicking the effects of phosphorylation of the C-terminal domain by PRKCA activation.
Increases channel activity upon positive potentials. The mutation corresponds to probable disease-associated variant in humans.
Protein N-terminal glutamine amidohydrolase
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Reduces at least 100-fold the inhibitory potency; when associated with 59-K--A-61.
Reduces at least 100-fold the inhibitory potency; when associated with P-43.
Dolichol-phosphate mannosyltransferase subunit 3
Coiled-coil domain-containing protein 82
Soluble interleukin-11 receptor subunit alpha
No effect on oxidant-mediated disulfide bond formation nor on in vitro PKC-mediated phosphorylation. No effect on oxidant-mediated disulfide bond formation; when associated with G-4 or S-9.
No effect on oxidant-mediated disulfide bond formation nor on in vitro PKC-mediated phosphorylation. No effect on oxidant-mediated disulfide bond formation; when associated with S-3 or G-4.
No effect on oxidant-mediated disulfide bond formation nor on in vitro PKC-mediated phosphorylation. No effect on oxidant-mediated disulfide bond formation; when associated with S-3 or S-9.
No oxidant-mediated disulfide bond formation. No effect on in vitro PKC-mediated phosphorylation. No oxidant-mediated disulfide bond formation; when associated with S-3; G-4 and S-9.
Cell adhesion molecule-related/down-regulated by oncogenes
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with GAS1.
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1 or GAS1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization.
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization.
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains very little residual activity even during overexpression and interacts with SHH, but does not interact with PTCH1, BOC, or GAS1.
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
Does not shuttle to the nucleus in response to NMDA stimulation.
Shuttles to the nucleus is irrespective of NMDA stimulation.
Inositol polyphosphate-4-phosphatase type I A
CB1 cannabinoid receptor-interacting protein 1
tRNA selenocysteine 1-associated protein 1
Lysosome-associated membrane glycoprotein 3
Aldehyde dehydrogenase family 1 member A3
Neuron-specific vesicular protein calcyon
Sodium- and chloride-dependent taurine transporter
Leucine-rich repeat-containing protein 55
Heterogeneous nuclear ribonucleoprotein H
Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
Cytochrome c oxidase subunit 5B, mitochondrial
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Modifies the transporter pH-sensitivity.
Sodium-coupled neutral amino acid transporter 5
Fumarylacetoacetate hydrolase domain-containing protein 2
Abolishes interactions with HOMER1C and NF2.
Abolishes phospholipid binding and nuclear localization; when associated with N-679.
Abolishes phospholipid binding and nuclear localization; when associated with N-687.
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
von Willebrand factor A domain-containing protein 1
Urokinase plasminogen activator surface receptor
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
Phosphoserine; by PKC/PRKCG and PKC/PRKCD
Transcription factor NF-E2 45 kDa subunit
Calcium/calmodulin-dependent protein kinase type 1B
Maestro heat-like repeat-containing protein family member 7
Interchain (with C-608 or C-609 in GP1BA)
Transcription elongation factor A protein-like 1
Aurora kinase A and ninein-interacting protein
Proprotein convertase subtilisin/kexin type 5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Constitutively active. Increases PAK1 and LIMK1 phosphorylation and NR3C2 nuclear localization in podocytes. In hippocampal neurons, increases the amount of dendritic protrusions and decreases the number of normal spines and synapses.
Constitutively active. Interacts with PPP5C.
Dominant negative. Reduces NMDA receptor-mediated synaptic currents.
Polybasic region; required for nuclear import
Ras-related C3 botulinum toxin substrate 1
Ubiquitin carboxyl-terminal hydrolase MINDY-1
Coiled-coil domain-containing protein 80
Leucine-rich glioma-inactivated protein 1
Ras association domain-containing protein 2
Sodium/potassium-transporting ATPase subunit beta-3
Loss of zinc export across plasma membrane and no effect on localization to the plasma membrane; when associated with A-254.
Loss of zinc export across plasma membrane and no effect on localization to the plasma membrane; when associated with A-43.
Hepatitis A virus cellular receptor 1 homolog
Abolishes binding with EDN1 without affecting angiotensin-2 peptide binding.
Abolishes binding with EDN1. Affects binding with angiotensin-2 peptide.
Dual endothelin-1/angiotensin II receptor
In Dahl R mutant. Does not affect expression levels; when associated with T-44. Loss of angiotensin-2 peptide binding; when associated with T-44. Does not affect EDN1 binding; when associated with T-44.
In Dahl R mutant. Does not affect expression levels; when associated with T-74. Loss of angiotensin-2 peptide binding; when associated with T-74. Does not affect EDN1 binding; when associated with T-74.
Mitochondrial 2-oxoglutarate/malate carrier protein
Glutaminase liver isoform, mitochondrial
Mitochondrial peptide methionine sulfoxide reductase
Guanine nucleotide-binding protein G(q) subunit alpha
Alkyldihydroxyacetonephosphate synthase, peroxisomal
Uncharacterized protein C16orf46 homolog
Metalloendopeptidase OMA1, mitochondrial
Loss of interactions with COPA and COPB2.
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Insulin-like growth factor-binding protein 6
Chromodomain-helicase-DNA-binding protein 8
Induces a decrease in sumoylation status.
60 kDa heat shock protein, mitochondrial
Endoplasmic reticulum resident protein 29
Proline-rich nuclear receptor coactivator 2
Receptor-type tyrosine-protein phosphatase F
Centromere/kinetochore protein zw10 homolog
Natural cytotoxicity triggering receptor 3
Eukaryotic translation initiation factor 5A-1
Plasma membrane ascorbate-dependent reductase CYBRD1
Echinoderm microtubule-associated protein-like 1
High affinity immunoglobulin epsilon receptor subunit alpha
Loss of function in dendrite development.
Glycosyltransferase-like domain-containing protein 1
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Coiled-coil domain-containing protein 116
Loss of palmitoylation and targeting to postsynaptic density.
DALR anticodon-binding domain-containing protein 3
Probable inactive tRNA-specific adenosine deaminase-like protein 3
Reduces sensitivity to alterations in external pH.
Target of rapamycin complex 2 subunit MAPKAP1
Pituitary-specific positive transcription factor 1
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Active breakpoint cluster region-related protein
Uncharacterized protein C12orf29 homolog
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Microtubule-actin cross-linking factor 1
Heterogeneous nuclear ribonucleoprotein D-like
Moderate reduction of protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities.
Moderate reduction of protein expression levels. No significant effect on catalytic activities.
No significant effect on protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities.
No significant effect on protein expression levels. Abolishes prostaglandin D synthase and significantly reduces glutathione-conjugating activities.
Significant reduction of protein expression levels. Abolishes prostaglandin D synthase and significantly reduces glutathione-conjugating activities.
Significant reduction of protein expression levels. Moderately reduces prostaglandin D synthase activity.
Significant reduction of protein expression levels. Significantly reduces prostaglandin D synthase and moderately reduces glutathione-conjugating activities.
Abolishes clustered subcellular distribution in neurons.
Abolishes clustered subcellular distribution in neurons. Does not affect KCNB1-containing vesicles motility.
Does not reduce apoptotic enhancement of potassium current during the cell death program.
Loss of SUMO-dependent channel activity modulation in hippocampal neurons.
No effect on Src-mediated phosphorylation.
No loss of SUMO-dependent channel activity modulation in hippocampal neurons.
Phosphoserine; by CDK5, MAPK14; in vitro
Potassium voltage-gated channel subfamily B member 1
Reduces channel activity. Does not inhibit membrane plasma subcellular localization, interaction with STX1A, pore-independent exocytosis activity and apoptotic enhancement of potassium current during cell death program; when associated with C-369.
Reduces channel activity. Does not inhibit membrane plasma subcellular localization, interaction with STX1A, pore-independent exocytosis activity and apoptotic enhancement of potassium current during cell death program; when associated with T-384.
Reduces the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program. No change in calcineurin-dependent regulation of voltage-dependent gating. Abolishes the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program; when associated with F-128.
Reduces the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program. Significant loss of Src-mediated phosphorylation and channel activity. Reduces interaction with PTPRE. Increases cell viability against apoptotic insults. Abolishes the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program; when associated with D-804.
Resists voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Additive effect on activation and steady-state inactivation; when associated with A-15.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Additive effect on activation and steady-state inactivation; when associated with A-457.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Larger effect on activation and steady-state inactivation; when associated with A-567.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Larger effect on activation and steady-state inactivation; when associated with A-607.
Sodium- and chloride-dependent GABA transporter 1
Eukaryotic translation initiation factor 3 subunit B
Interchain (with C-115 in TAPBP); in linked form
17-beta-hydroxysteroid dehydrogenase type 6
Phosphatidylcholine-sterol acyltransferase
Reduced activity with 20-carbon phosphatidylcholine as substrate. Little change with 18-carbon phosphatidylcholine as substrate.
Melanoma-derived growth regulatory protein
Hydroxyacylglutathione hydrolase, mitochondrial
Splicing factor, arginine/serine-rich 19
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Abolishes affinity for POPC/POPS in the absence of Ca(2+); when associated with E-714.
Abolishes affinity for POPC/POPS in the absence of Ca(2+); when associated with E-718.
Only retains weak enzyme activity and abolishes the ability of isoform 4 to act as a negative regulator.
Does not inhibit calcium-dependent translocation to the cell membrane. Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-229. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-168; N-174 and N-230.
Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-33; N-35 and N-104.
Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-33; N-35 and N-93.
Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-33; N-93 and N-104.
Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-35; N-93 and N-104.
Inhibits strongly calcium-dependent translocation to the cell membrane. Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-167. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-167; N-230 and N-232.
Inhibits strongly calcium-dependent translocation to the cell membrane. Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-173. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-174; N-230 and N-232.
Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-231. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-167; N-174 and N-232.
Post-GPI attachment to proteins factor 2
Proprotein convertase subtilisin/kexin type 6
Increases specific activity against PNPC by 6-fold and against PNPA by 8.7-fold, no activity on cholesteryl oleate. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold; when associated with I-423.
Increases specific activity against PNPC by 8-fold, does not increase activity against PNPA, no activity on cholesteryl oleate. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; T-491 and E-492. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold; when associated with S-506.
No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate. No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with E-492; or with T-491 and E-492. Increases activity on PNPC compared to activity on PNPA; when associated with I-423; T-491 and E-492.
No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with R-186 and E-492. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; I-423 and E-492.
No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with R-186; or with R-186 and T-491. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; I-423 and T-491.
Complement component receptor 1-like protein
Tumor necrosis factor ligand superfamily member 15
Synaptonemal complex central element protein 1
Gamma-aminobutyric acid receptor subunit beta-2
Nuclear receptor subfamily 1 group D member 1
Metallo-beta-lactamase domain-containing protein 1
Vimentin-type intermediate filament-associated coiled-coil protein
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Abolished protein-glutamine gamma-glutamyltransferase activity without affecting alpha-1 adrenergic receptor signaling.
Destabilizes the compact conformation in presence of GTP.
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Protein-glutamine gamma-glutamyltransferase 2
Galactoside alpha-(1,2)-fucosyltransferase 2
5'-nucleotidase domain-containing protein 2
receptor protein serine/threonine kinase
Cytochrome c oxidase subunit 5A, mitochondrial
Solute carrier family 2, facilitated glucose transporter member 3
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
Programmed cell death 6-interacting protein
Asparagine synthetase [glutamine-hydrolyzing]
Vesicle transport through interaction with t-SNAREs homolog 1A
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Vitamin K epoxide reductase complex subunit 1-like protein 1
SURP and G-patch domain-containing protein 1
Angiotensin-converting enzyme, soluble form
Nuclear receptor subfamily 0 group B member 2
Golgi-associated RAB2 interactor protein 1B
Cation channel sperm-associated auxiliary subunit delta
Transforming growth factor beta-2 proprotein
Mitogen-activated protein kinase kinase kinase 11
Myeloid-associated differentiation marker-like protein 2
Testicular haploid expressed gene protein
Isoaspartyl glycine isopeptide (Asn-Gly); alternate
Zinc finger CCHC domain-containing protein 10
Guanine nucleotide-binding protein G(t) subunit alpha-3
Loss of activation by both bitter and sweet compounds due to disruption of interaction with taste receptors.
Hippocampal cholinergic neurostimulating peptide
N-acetylalanine; in peptide hippocampal cholinergic neurostimulating
Phosphatidylethanolamine-binding protein 1
Submandibular gland secretory Glx-rich protein CB
Fibronectin type 3 and ankyrin repeat domains 1 protein
Sodium channel protein type 11 subunit alpha
3-fold decrease of affinity for phosphoenolpyruvate.
Abolished phosphoenolpyruvate carboxykinase activity; decreased affinity for oxaloacetate.
Decreased phosphorylation and increased acetylation levels.
Destabilization of the closed state of the omega-loop, resulting in decreased capture rates for the weaker binding substrates associated with catalysis in the phosphoenolpyruvate to oxaloacetate direction.
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Coiled-coil domain-containing protein 86
POU domain, class 6, transcription factor 1
26S proteasome non-ATPase regulatory subunit 13
25-hydroxycholesterol 7-alpha-hydroxylase
Cytochrome c oxidase subunit 7C, mitochondrial
CHRNA9-CHRNA10 receptor is 25-fold less potently inhibited by the alpha-conotoxin RgIA.
CHRNA9-CHRNA10 receptor is 300-fold less potently inhibited by the alpha-conotoxin RgIA.
Neuronal acetylcholine receptor subunit alpha-10
Broad substrate specificity ATP-binding cassette transporter ABCG2
Abolishes phosphorylation by CDK5 and subsequent phosphorylation by PLK2, leading to prevent ubiquitination and degradation by the proteasome.
Abolishes stimulation of the GTPase activity of RAP2A.
Abolishes ubiquitination and degradation by the proteasome; when associated with A-1344.
Abolishes ubiquitination and degradation by the proteasome; when associated with A-1348.
Decreases stimulation of the GTPase activity of RAP2A.
Signal-induced proliferation-associated 1-like protein 1
Cyclin-dependent kinase 5 activator 1, p25
Cyclin-dependent kinase 5 activator 1, p35
Decreased susceptibility to calpain cleavage.
Increased susceptibility to calpain cleavage.
Elongation of very long chain fatty acids protein 6
Uridine diphosphate glucose pyrophosphatase NUDT22
Leucine-rich repeat and fibronectin type-III domain-containing protein 3
Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Glycine cleavage system H protein, mitochondrial
Echinoderm microtubule-associated protein-like 2
CLK4-associating serine/arginine rich protein
Arginine-hydroxylase NDUFAF5, mitochondrial
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Inhibitor of nuclear factor kappa-B kinase subunit beta
Phosphoserine; by TBK1, PKC/PRKCZ and PDPK1
Myb/SANT-like DNA-binding domain-containing protein 4
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
N-acetylvaline; in SUMO-activating enzyme subunit 1, N-terminally processed
SUMO-activating enzyme subunit 1, N-terminally processed
Mitochondrial import inner membrane translocase subunit Tim17-A
Ubiquitin-like modifier-activating enzyme 5
RNA polymerase II elongation factor ELL3
Biorientation of chromosomes in cell division protein 1
Loss of serine/threonine-protein kinase without affecting interaction with SPRED1.
WD repeat domain phosphoinositide-interacting protein 4
Increases KM for ornithine 5-fold and decreases kcat 20-fold.
Ornithine transcarbamylase, mitochondrial
Strong decrease in ornithine carbamoyltransferase activity.
Solute carrier family 52, riboflavin transporter, member 2
cGMP-specific 3',5'-cyclic phosphodiesterase
Sodium/potassium-transporting ATPase subunit alpha-2
Voltage-dependent L-type calcium channel subunit beta-4
PTB domain-containing engulfment adapter protein 1
In isoform 10, isoform 12, isoform 14, isoform 16, isoform 17 and isoform 19.
In isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 18 and isoform 19.
Axonemal dynein light intermediate polypeptide 1
Acetylcholinesterase collagenic tail peptide
WAP four-disulfide core domain protein 1
Zinc finger and BTB domain-containing protein 18
Decreases internalization from the cell membrane in response to PKC activation.
Reduced palmitoylation. Loss of palmitoylation; when associated with A-13.
Reduced palmitoylation. Loss of palmitoylation; when associated with A-17.
Zinc finger CCHC domain-containing protein 7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Potassium voltage-gated channel subfamily E member 3
Tumor necrosis factor ligand superfamily member 6, membrane form
Tumor necrosis factor ligand superfamily member 6, soluble form
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
DAP3-binding cell death enhancer 1 short form
Abolishes catalytic activity. Decreases substrate binding affinity.
Abolishes catalytic activity. No effect on substrate binding.
Greatly decreased activation by polyphosphate anions, and deficient in activation by small peptides; when associated with A-898 and A-899.
Greatly decreased activation by polyphosphate anions, and deficient in activation by small peptides; when associated with A-898 and A-901.
Greatly decreased activation by polyphosphate anions, and deficient in activation by small peptides; when associated with A-899 and A-901.
Greatly decreased activation by polyphosphate anions.
Strongly reduced catalytic activity. Abolishes stimulation of activity by ATP.
Strongly reduced catalytic activity. Strongly reduced stimulation of activity by ATP.
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
STE20/SPS1-related proline-alanine-rich protein kinase
Protein mono-ADP-ribosyltransferase PARP16
Endothelial PAS domain-containing protein 1
Polypeptide N-acetylgalactosaminyltransferase 13
Guanylate cyclase soluble subunit beta-1
Abrogates CRM1-independent nuclear export.
Double-stranded RNA-binding protein Staufen homolog 2
Reduced infarct size, neuronal death and neurobehavioral dysfunction in response to cerebral ischemia/reperfusion (I/R) injury.
DNA damage-regulated autophagy modulator protein 2
Leucine zipper putative tumor suppressor 2
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Tyrosine-protein phosphatase non-receptor type 20
DNA-(apurinic or apyrimidinic site) endonuclease
DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial
26S proteasome non-ATPase regulatory subunit 1
Superoxide dismutase [Mn], mitochondrial
Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK3
Phosphothreonine; by MLCK, CIT and ROCK2
Post-GPI attachment to proteins factor 4
Spindle and kinetochore-associated protein 3
Interactor protein for cytohesin exchange factors 1
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase soluble form
ELKS/Rab6-interacting/CAST family member 1
Weakens RIMS1 and abolishes RIMS2 binding.
ATP synthase subunit C lysine N-methyltransferase
Endoplasmic reticulum membrane adapter protein XK
Oncoprotein-induced transcript 3 protein
Heterogeneous nuclear ribonucleoprotein L
Alpha/beta hydrolase domain-containing protein 17B
Lysosomal-associated transmembrane protein 4B
CAP-Gly domain-containing linker protein 1
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-313 and A-319.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-313 and A-320.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-319 and A-320.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-313; A-319 and A-320.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-311; A-313; A-319 and A-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-311; E-319 and E-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-313; E-319 and E-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-30; E-311; E-313 and E-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-311; E-313; E-319 and E-320.
Phosphomimetic mutant, exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-311; E-313 and E-319.
Abolishes interaction with PPP1CA and PPP1CA inhibition.
Does not abolish interaction with PPP1CA and does not reduce PPP1CA inhibition.
Does not abolish interaction with PPP1CA and reduces a little PPP1CA inhibition.
Reduces interaction with PPP1CA and reduces strongly PPP1CA inhibition.
Serine/threonine-protein phosphatase 1 regulatory subunit 10
Guanine nucleotide-binding protein G(z) subunit alpha
Histone-lysine N-methyltransferase KMT5C
Epithelial splicing regulatory protein 1
Microfibrillar-associated protein 3-like
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Sodium channel protein type 9 subunit alpha
Trafficking protein particle complex subunit 3
No in vitro cleavage by caspase-3; when associated with E-591. Results in loss of JNK activation; when associated with E-591.
No in vitro cleavage by caspase-3; when associated with E-594. Results in loss of JNK activation; when associated with E-594.
Abolishes cleavage. Abolishes cell surface localization.
Abolishes cleavage. No effect on cell surface localization.
Tumor necrosis factor receptor superfamily member 21
Phenazine biosynthesis-like domain-containing protein
N-linked (GlcNAc...) asparagine; partial
Processed zona pellucida sperm-binding protein 2
N-linked (GlcNAc...) (complex) asparagine
Xylosyl- and glucuronyltransferase LARGE2
Alpha/beta hydrolase domain-containing protein 17A
Intracellular hyaluronan-binding protein 4
G protein-activated inward rectifier potassium channel 1
Alters binding to poly-SUMO chains. Loss of binding and ubiquitination of poly-SUMO chains; when associated with 40-A--A-43; 61-A--A-63 and 71-A--A-74.
Loss of ubiquitination activity; when associated with S-136.
Loss of ubiquitination activity; when associated with S-139.
Loss of ubiquitination activity; when associated with S-177.
Loss of ubiquitination activity; when associated with S-180.
No effect. Loss of binding and ubiquitination of poly-SUMO chains; when associated with 40-A--A-43; 50-A--A-53 and 61-A--A-63.
No effect. Loss of binding and ubiquitination of poly-SUMO chains; when associated with 40-A--A-43; 50-A--A-53 and 71-A--A-74.
No effect. Loss of binding and ubiquitination of poly-SUMO chains; when associated with 50-A--A-53; 61-A--A-63 and 71-A--A-74.
MAP kinase-interacting serine/threonine-protein kinase 1
4-hydroxybenzoate polyprenyltransferase, mitochondrial
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Insulin-like growth factor-binding protein 1
Phosphatidate cytidylyltransferase, mitochondrial
Rho guanine nucleotide exchange factor 6
Myosin light chain kinase 2, skeletal/cardiac muscle
WD repeat, SAM and U-box domain-containing protein 1
In isoform 3, isoform 4, isoform 6 and isoform 8.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-166 and A-336.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-166.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-336.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-96, A-166 and A-336.
Abolishes basal phosphorylation; when associated with A-363. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-375. Accelerates agonist-induced receptor internalization.
Abolishes basal phosphorylation; when associated with A-370. Abolishes basal and agonist-induced phosphorylation; when associated with A-370 and A-375. Accelerates agonist-induced receptor internalization.
Constitutive active. Some constitutive activity; when associated with E-275.
Decrease in phosphorylation, no decrease in G-protein binding.
Impairs ARRB2- and GRK3-mediated receptor desensitization.
Impairs agonist affinity and increases agonist-induced inhibition of adenylate cyclase.
Impairs agonist affinity, agonist-induced inhibition of adenylate cyclase and coupling to G-proteins.
Impairs phosphorylation and abolishes agonist-mediated acute receptor desensitization.
NPxxY; plays a role in stabilizing the activated conformation of the receptor
No change in palmitoylation. No change in palmitoylation; when associated with A-351.
No change in palmitoylation; when associated with A-346.
No effect on constitutive activation. Impairs agonist affinity and agonist-induced inhibition of adenylate cyclase.
No effect on constitutive activation. Some constitutive activity; when associated with K-279.
No effect on inhibition of adenylate cyclase.
Reduces agonist-induced receptor internalization. Abolishes morphine-induced phosphorylation. Restores agonist-specific PRKCE activity. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-370.
Abolishes interaction with phosphorylated INSR.
Abolishes phosphorylation in response to insulin.
Reduces interaction with phosphorylated INSR.
Ribosome biogenesis regulatory protein homolog
Changes carbohydrate binding specificity, leading to interaction with Lewis blood group antigens.
Disrupts homotrimer formation. 5-fold reduction in secretion rate. Prevents K-44 hydroxylation and glycosylation. 10-fold decrease in complement activation.
Disrupts homotrimer formation. 5-fold reduction in secretion rate. Prevents K-47 hydroxylation and glycosylation.
No effect on secretion rate, nor on homooligomer formation. 3-fold reduction in secretion rate; when associated eith R-44. Prevents higher-order oligomer assembly; when associated eith R-44. 10-fold decrease in complement activation; when associated eith R-44.
No effect on secretion rate, nor on homooligomer formation. 3-fold reduction in secretion rate; when associated eith R-47. Prevents higher-order oligomer assembly; when associated eith R-47. 10-fold decrease in complement activation; when associated eith R-47.
Prevents higher-order oligomer assembly. Slight reduction in secretion rate.
IQ and ubiquitin-like domain-containing protein
DINNN-motif; mediates interaction with SPSB1, SPSB2 and SPSB4
Sushi, nidogen and EGF-like domain-containing protein 1
MKI67 FHA domain-interacting nucleolar phosphoprotein
von Hippel-Lindau disease tumor suppressor
Meiosis-specific nuclear structural protein 1
Abolishes midbody localization and shows increased multinucleation.
Reduces proline-rich domain phosphorylation by 80%.
Strongly reduced phosphorylation. Decreases receptor-mediated endocytosis.
SH3 domain-binding glutamic acid-rich-like protein 3
Voltage-dependent L-type calcium channel subunit beta-1
Inhibits insulin-induced activation of endogenous Akt1, insulin-stimulated protein synthesis, insulin-induced activation of glycogen synthase and insulin-induced phosphorylation of 4E-BP1 in a dominant negative manner when overexpressed; when associated with A-308.
Inhibits insulin-induced activation of endogenous Akt1, insulin-stimulated protein synthesis, insulin-induced activation of glycogen synthase and insulin-induced phosphorylation of 4E-BP1 in a dominant negative manner when overexpressed; when associated with A-473.
Lacks kinase activity. Inhibits insulin-induced activation of glycogen synthase when expressed.
Phosphoserine; by IKKE, MTOR and TBK1; alternate
Phosphothreonine; by IKKE, PDPK1 and TBK1
RAC-alpha serine/threonine-protein kinase
Methionyl-tRNA formyltransferase, mitochondrial
Dominant negative; secreted and retains ability to homooligomerize.
Eukaryotic translation initiation factor 2 subunit 1
39S ribosomal protein L37, mitochondrial
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Mitotic spindle assembly checkpoint protein MAD2B
Abolished angiotensin II-induced inositol phosphate response.
Decreased angiotensin II-induced inositol phosphate response.
Increased angiotensin II-induced inositol phosphate response.
Reduced angiotensin II-induced inositol phosphate response.
For poly [ADP-ribose] polymerase activity
Poly [ADP-ribose] polymerase 1, processed C-terminus
Poly [ADP-ribose] polymerase 1, processed N-terminus
ATP-binding cassette sub-family C member 8
Chromodomain-helicase-DNA-binding protein 6
Geranylgeranyl transferase type-1 subunit beta
Alpha-2-macroglobulin receptor-associated protein
Glutamate--cysteine ligase catalytic subunit
WAP four-disulfide core domain protein 2
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
Mitochondrial import receptor subunit TOM34
In strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd.
In strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd.
Tumor necrosis factor receptor superfamily member 1A
DNA-directed RNA polymerase I subunit RPA1
Thiazolidine linkage to a ring-opened DNA abasic site
Pleckstrin homology domain-containing family G member 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Unique cartilage matrix-associated protein
Unique cartilage matrix-associated protein C-terminal fragment
G protein-activated inward rectifier potassium channel 4
Mannose-1-phosphate guanyltransferase alpha
Solute carrier organic anion transporter family member 1A5
N-acetylmethionine; in RNA binding motif protein, X-linked-like-1; alternate
N-acetylvaline; in RNA binding motif protein, X-linked-like-1, N-terminally processed
RNA-binding motif protein, X chromosome retrogene-like
RNA-binding motif protein, X chromosome retrogene-like, N-terminally processed
Interferon-stimulated 20 kDa exonuclease-like 2
All trans-polyprenyl-diphosphate synthase PDSS2
Protein phosphatase 1 regulatory subunit 14A
Segment polarity protein dishevelled homolog DVL-1
Impairs synaptic transmission. Abolishes the chloride ion conductance.
Loss of L-glutamate release. Abolishes the chloride ion conductance.
Translocon-associated protein subunit delta
Loss of interaction with OSBPL1A; when associated with D-94.
Loss of interaction with OSBPL1A; when associated with D-96.
Vesicle-associated membrane protein-associated protein A
Cell division cycle-associated protein 3
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Decreased ANP-dependent guanylate cyclase activity; when associated with H-338.
Decreased ANP-dependent guanylate cyclase activity; when associated with P-364.
Loss of ANP binding and ANP-dependent guanylate cyclase activities.
Markedly reduced phosphorylation, 50% loss of CNP-dependent activity.
No effect on phosphorylation, 15% loss of ANP-dependent activity.
No effect on phosphorylation, 30% loss of ANP-dependent activity.
Reduced phosphorylation, 50% loss of ANP-dependent activity.
Reduced phosphorylation, 60% loss of CNP-dependent activity.
Reduced phosphorylation, 80% loss of ANP-dependent activity.
12-fold increase in affinity to the conotoxin BuIA (11-fold decrease in K(off)).
19-fold increase in affinity to the conotoxin BuIA (7-fold decrease in K(off)).
20-fold increase in affinity to the conotoxin BuIA (37-fold decrease in K(off)); 2-fold decrease in affinity to the conotoxin MII (no change in K(off), but 2-fold decrease in K(on)).
3-fold increase in affinity to the conotoxin BuIA (2-fold decrease in K(off)).
40-fold, 165-fold, and 300-fold decrease in inhibition of alpha-3-beta-2(L118Q) nAChR by alpha-conotoxins PnIA, GID and MII, respectively.
6.6-fold increase in affinity to the conotoxin BuIA (7-fold decrease in K(off)).
8.3-fold decrease in affinity to the conotoxin BuIA (4-fold increase in K(off) and a 2-fold decrease in K(on)).
9-fold increase in affinity to the conotoxin BuIA (15-fold decrease in K(off)).
Neuronal acetylcholine receptor subunit beta-2
No change in inhibition of alpha-3-beta-2(F143A) nAChR by alpha-conotoxins PnIA, GID and MII. 12-fold and 6.6-fold increase in inhibition of alpha-4-beta-2(F143A) nAChR by alpha-conotoxins GID and MII, respectively, but no change in inhibition of the same receptor by alpha-conotoxin PnIA.
No change in inhibition of alpha-3-beta-2(V135G) nAChR by alpha-conotoxins GID and MII. 4.4-fold decrease in inhibition of alpha-3-beta-2(V135G) nAChR by alpha-conotoxins PnIA.
Very small decrease or no change in inhibition of alpha-3-beta-2(V135A) nAChR by alpha-conotoxins PnIA, GID and MII.
H/ACA ribonucleoprotein complex non-core subunit NAF1
Lowers homodimerization and decreases receptor activity.
Mas-related G-protein coupled receptor member H
Arginine amide; in CCB peptide short form
CCB peptide long form without any modifications.
CCB peptide short form without any modifications.
Sulfated and phosphorylated CCB peptide long form.
Sulfated and phosphorylated CCB peptide short form.
Sulfated or phosphorylated CCB peptide long form.
Sulfated or phosphorylated CCB peptide short form.
Lung adenoma susceptibility protein 2 homolog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Increased GTP dissociation and decreased GDP hydrolysis.
Increased rates of GTP binding and GDP dissociation.
Branched-chain-amino-acid aminotransferase, mitochondrial
Breast carcinoma-amplified sequence 1 homolog
In isoform 3, isoform 4, isoform 5 and isoform 6.
Platelet-derived growth factor receptor beta
Decreased AMN-dependent trafficking to the cell surface.
Impaired glycosylation and loss of export to the cell surface; when associated with D-711; D-749 and D-781.
Impaired glycosylation and loss of export to the cell surface; when associated with D-711; D-749 and D-857.
Impaired glycosylation and loss of export to the cell surface; when associated with D-711; D-781 and D-857.
Impaired glycosylation and loss of export to the cell surface; when associated with D-749; D-781 and D-857.
No effect on trafficking to the cell surface.
Mitochondrial potassium channel ATP-binding subunit
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Loss of aldehyde dehydrogenase activity.
Loss of formyltetrahydrofolate dehydrogenase activity. Loss of formyltetrahydrofolate hydrolase activity. No effect on aldehyde dehydrogenase activity.
Loss of formyltetrahydrofolate dehydrogenase activity. No effect on formyltetrahydrofolate hydrolase activity. No effect on NADP binding. No effect on homotetramerization.
Loss of phosphopantetheinylation. Loss of formyltetrahydrofolate dehydrogenase activity. No effect on hydrolase and aldehyde dehydrogenase activities in vitro.
Reduced interaction with RELA. Reduced translocation to the nucleus. Reduced activation of NF-kappa-B transcription factor activity.
Collagen triple helix repeat-containing protein 1
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Proheparin-binding EGF-like growth factor
Acyl-CoA-binding domain-containing protein 6
Complement C1q tumor necrosis factor-related protein 5
Sodium-dependent phosphate transport protein 2C
Dehydrogenase/reductase SDR family member 7C
Reduces interaction with HSP70; impairs interaction with HSP90.
Dual specificity testis-specific protein kinase 1
Loss of autophosphorylation site, loss of kinase activity.
Loss of autophosphorylation site, no effect on kinase activity.
Loss of kinase and autophosphorylating activity. Abolishes TESK1-induced actin stress fiber formation. No effect on interaction with YWHAB, SPRY2 or SPRED1. No effect on TESK1-mediated dephosphorylation of SPRY2.
Major intrinsically disordered Notch2-binding receptor 1
Probable ATP-dependent RNA helicase DHX40
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Hyaluronan and proteoglycan link protein 2
For hydroxyacyl-coenzyme A dehydrogenase activity
Trifunctional enzyme subunit alpha, mitochondrial
Embryonic polyadenylate-binding protein 2
X-ray repair cross-complementing protein 5
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
28S ribosomal protein S26, mitochondrial
Rho guanine nucleotide exchange factor 28
Zinc finger protein with KRAB and SCAN domains 1
Bile acid-CoA:amino acid N-acyltransferase
Small conductance calcium-activated potassium channel protein 1
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
Insulin-like growth factor 2 mRNA-binding protein 1
Loss of function in dendritogenesis; when associated with 213-E-L-214 and 294-E-L-295.
Loss of function in dendritogenesis; when associated with 213-E-L-214 and 423-E-L-424.
Loss of function in dendritogenesis; when associated with 294-E-L-295 and 423-E-L-424.
Mothers against decapentaplegic homolog 7
Cysteinyl-selenocysteine (Sec-Cys); in isoform Se-P1
ADP-ribosylation factor-like protein 6-interacting protein 4
Sodium channel protein type 8 subunit alpha
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Loss of autophosphorylation and activity.
Loss of autophosphorylation and activity. Loss of autophosphorylation and activity; when associated with A-176.
Loss of autophosphorylation and activity. Loss of autophosphorylation and activity; when associated with F-178.
PXXXP motif; regulates binding with chromatin and interaction with PCNA
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
ATP-dependent 6-phosphofructokinase, platelet type
Peptidyl-prolyl cis-trans isomerase-like 3
ATP-binding cassette sub-family A member 2
Loss of GTPase activity. No effect on oligomerization.
Voltage-dependent anion-selective channel protein 3
Tumor necrosis factor ligand superfamily member 4
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Betaine--homocysteine S-methyltransferase 1
Decreases the catalytic efficiency. Decreases the affinity for glycine betaine.
Decreases the catalytic efficiency. Increases the affinity for L-homocysteine.
Has no effect on tetramer assembly or catalytic efficiency.
Has no effect on tetramer assembly. Decreases the catalytic efficiency.
Has no effect on tetramer assembly. Decreases the catalytic efficiency. Alters nucleocytoplasmic distribution.
Microtubule-associated proteins 1A/1B light chain 3B
Decreased association with HDAC1; when associated with A-772 and A-780.
Decreased association with HDAC1; when associated with A-772 and A-787.
Decreased association with HDAC1; when associated with A-780 and A-787.
TATA box-binding protein-associated factor RNA polymerase I subunit B
Protein phosphatase 1 regulatory subunit 3C
Sodium-dependent phosphate transport protein 2B
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51
Inositol 1,4,5-trisphosphate receptor-interacting protein
Potassium voltage-gated channel subfamily A member 4
Voltage-dependent calcium channel gamma-7 subunit
Neuronal vesicle trafficking-associated protein 2
Decreased binding of fragment 1-61 to BoNT/B heavy chain.
Nearly wild-type binding of fragment 1-61 to BoNT/B heavy chain.
No binding of fragment 1-61 to BoNT/B heavy chain.
BMP/retinoic acid-inducible neural-specific protein 2
Coiled-coil domain-containing protein 175
Protein phosphatase 1 regulatory subunit 3B
Processed PDZ domain-containing protein 2
N-terminal EF-hand calcium-binding protein 2
Almost complete loss of binding to GNAO1. No inhibition of GTPase activity.
Little oxidized neuronal proteins. Scarce amyloid-beta protein 42 aggregation. No neurotoxicity.
No chondroitin sulfate linkage to isoform L-APP733.
No effect on neurite growth and maturation.
O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms
YENPXY motif; contains endocytosis signal
Testicular haploid expressed gene protein-like
Uncharacterized protein C16orf86 homolog
Elongation of very long chain fatty acids protein 7
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Mitochondrial import receptor subunit TOM40 homolog
No effect on dopamine transport activity; when associated with G-403.
No effect on dopamine transport activity; when associated with G-404.
Reduced dopamine transport activity; when associated with A-356.
Reduced dopamine transport activity; when associated with A-359.
Reduced dopamine transport activity; when associated with G-356.
Reduced dopamine transport activity; when associated with G-359.
Significant loss of dopamine transport activity.
39S ribosomal protein L24, mitochondrial
Gamma-aminobutyric acid receptor subunit gamma-3
Diphosphoinositol polyphosphate phosphohydrolase 2
Disintegrin and metalloproteinase domain-containing protein 15
S-farnesyl cysteine; in plasma membrane form
S-geranylgeranyl cysteine; in endosomal form
BAG family molecular chaperone regulator 5
Zinc finger CCCH domain-containing protein 18
Does not affect alanine transport activity.
Does not affect amino acid transport activity. Significantly decreases alanine transport activity.
Does not affect cell membrane localization.
Does not affect cell membrane localization. Eliminates the sodium-induced anion leak current. Inhibits amino acid transport activity. Reduces affinity for sodium ion.
Does not affect the alanine-induced transport current. Reduces the amino acid affinity.
Impairs amino acid transport. Impairs the interaction of SNAT2 with the cotransported sodium ion.
Impairs transport current. Reduces the amino acid affinity.
Loss of amino acid transport activity. Loss of amino acid uptake activity. Reduces the amino acid affinity.
Partially loss of glycosylation. Completely loss of glycosylation; when associated with Q-258 and Q-272. Decreases expression; when associated with Q-258 and Q-272. Does not affect cell membrane localization; when associated with Q-258 and Q-272.
Partially loss of glycosylation. Dramatically loss of glycosylation; when associated with Q-258. Completely loss of glycosylation; when associated with Q-254 and Q-258. Decreases expression; when associated with Q-258. Decreases expression; when associated with Q-254 and Q-258. Does not affect cell membrane localization; when associated with Q-258. Does not affect cell membrane localization; when associated with Q-254 and Q-258.
Partially loss of glycosylation. Dramatically loss of glycosylation; when associated with Q-272. Completely loss of glycosylation; when associated with Q-254 and Q-272. Decreases expression; when associated with Q-272. Decreases expression; when associated with Q-254 and Q-272. Does not affect cell membrane localization; when associated with Q-272. Does not affect cell membrane localization; when associated with Q-254 and Q-272.
Reduces amino acid transport activity of 75%. Significantly decreases alanine transport activity.
Significantly decreases alanine transport activity.
Sodium-coupled neutral amino acid symporter 2
Spliceosome-associated protein CWC27 homolog
Reduces phosphorylation and inhibits DNA-binding and transcriptional activation.
Mitochondrial outer membrane protein SLC25A46
Katanin p60 ATPase-containing subunit A1
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
Androgen-dependent TFPI-regulating protein
Biogenesis of lysosome-related organelles complex-1 subunit 2
Probable E3 ubiquitin-protein ligase MARCHF10
ADP-ribosylation factor GTPase-activating protein 3
3-fold decrease in catalytic efficiency for NADH.
No significant effect on catalytic efficiency for NADH.
Regulating synaptic membrane exocytosis protein 1
All-trans-retinol dehydrogenase [NAD(+)] ADH7
Homologous recombination OB-fold protein
Pleckstrin homology domain-containing family F member 1
No change in secretion; when associated with S-297.
No change in secretion; when associated with T-186.
39S ribosomal protein L23, mitochondrial
Cilia- and flagella-associated protein 418
Not phosphorylated and perinuclear upon NMDA treatment.
N-acetylthreonine; in Histone H1.0, N-terminally processed
Hydroxymethylglutaryl-CoA lyase, mitochondrial
Zinc finger MYND domain-containing protein 10
Succinate dehydrogenase assembly factor 2, mitochondrial
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Constitutively activates downstream transcription factor function.
Fails to activate downstream transcription factor function.
Mitochondrial brown fat uncoupling protein 1
No effect on GTP-binding. Decreased fatty acid-induced proton transport.
No effect on GTP-binding. Decreased fatty acid-induced proton transport. Loss of fatty acid-induced proton transport; when associated with A-25 and A-31.
No effect on GTP-binding. Decreased fatty acid-induced proton transport; when associated with L-146.
No effect on GTP-binding. Decreased fatty acid-induced proton transport; when associated with L-148.
No effect on GTP-binding. Loss of fatty acid-induced proton transport; when associated with V-28 and A-31.
No effect on GTP-binding. No effect on fatty acid-induced proton transport. Loss of fatty acid-induced proton transport; when associated with A-25 and V-28.
Neuronal acetylcholine receptor subunit alpha-6
No effect on enzyme activity; when associated with A-170.
No effect on enzyme activity; when associated with H-173.
Phosphoserine; by ATM and ATR and dsDNA kinase
Transcription intermediary factor 1-beta
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Mannan-binding lectin serine protease 1 heavy chain
Mannan-binding lectin serine protease 1 light chain
Prevents protease self-activation through proteolytic cleavage into heavy and light chain.
Type II inositol 3,4-bisphosphate 4-phosphatase
Pseudouridylate synthase RPUSD4, mitochondrial
CCHC-type zinc finger nucleic acid binding protein
Pulmonary surfactant-associated protein A
Uncharacterized protein C11orf97 homolog
Myosin phosphatase Rho-interacting protein
Potassium voltage-gated channel subfamily C member 1
Reduces extent of N-glycosylation. Abolishes N-glycosylation; when associated with Q-220.
Reduces extent of N-glycosylation. Abolishes N-glycosylation; when associated with Q-229.
tRNA (guanine(10)-N2)-methyltransferase homolog
Activity-dependent neuroprotector homeobox protein
Abolishes interaction with DNM1, SYNJ1 and WASL.
No effect on membrane-binding. Reduces membrane tubulation.
Protein kinase C and casein kinase substrate in neurons protein 1
Reduces membrane tubulation; when associated with A-276.
Reduces membrane tubulation; when associated with A-280.
Reduces membrane-binding. Abolishes membrane tubulation.
Reduces membrane-binding. Abolishes membrane tubulation; when associated with Q-127.
Reduces membrane-binding; when associated with Q-130. Abolishes membrane tubulation.
Phorbol-12-myristate-13-acetate-induced protein 1
Lipolysis-stimulated lipoprotein receptor
Zinc finger MYND domain-containing protein 19
Aldehyde dehydrogenase family 16 member A1
Killer cell lectin-like receptor subfamily B member 1B allele A
Aryl hydrocarbon receptor nuclear translocator 2
PIN2/TERF1-interacting telomerase inhibitor 1
Zinc finger and BTB domain-containing protein 44
tRNA modification GTPase GTPBP3, mitochondrial
Abolishes HA-RAS-mediated activation. Loss of in vitro ERK2-mediated phosphorylation. No change in sumoylation levels.
Decreased phosphorylation levels. Reduced NGF-mediated enhanced transactivation.
Greatly reduced protein stabilization on NGF stimulation.
Increased protein stabilization on NGF-treatment, but no increase when treated with MAPK-inhibitor; when associated with D-362. Some loss of protein stablization on NGF-treatment; wnen associated with A-362.
Increased protein stabilization on NGF-treatment, but no increase when treated with MAPK-inhibitor; when associated with D-374.
Loss of NGF-mediated phosphorylation; when associated with A-325.
Loss of NGF-mediated phosphorylation; when associated with A-331.
Phosphoserine; by MAPK1, MAPK3 and RPS6KA3
Some loss of protein stabilization on NGF-treatment; when associated with D-374.
Sperm acrosome membrane-associated protein 3
Calcium-activated potassium channel subunit beta-4
Specifically androgen-regulated gene protein
Abolishes in vitro phosphorylation by Src and Lck.
Spectrin alpha chain, non-erythrocytic 1
Inhibitor of nuclear factor kappa-B kinase-interacting protein
Aflatoxin B1 aldehyde reductase member 2
Pleckstrin homology domain-containing family O member 1
NKG2-D type II integral membrane protein
Heart- and neural crest derivatives-expressed protein 1
Pulmonary surfactant-associated protein C
WAP four-disulfide core domain protein 12
Microtubule-associated tumor suppressor 1 homolog
CCR4-NOT transcription complex subunit 10
Beta-galactoside alpha-2,6-sialyltransferase 2
RNA/RNP complex-1-interacting phosphatase
Eukaryotic translation initiation factor 2 subunit 3, X-linked
Abolishes phosphorylation by CaMK2. No effect on kinetic parameters; when associated with A-196 and A-214.
Abolishes phosphorylation by CaMK2. No effect on kinetic parameters; when associated with A-46 and A-196.
Abolishes phosphorylation by CaMK2. No effect on kinetic parameters; when associated with A-46 and A-214.
Reduces activity 4-fold. Loss of activity; when associated with V-171.
Reduces affinity for NADP and for sepiapterin 4-fold.
SKI family transcriptional corepressor 1
Oxidative stress-responsive serine-rich protein 1
Dipeptidyl aminopeptidase-like protein 6
Katanin p60 ATPase-containing subunit A-like 1
FYVE, RhoGEF and PH domain-containing protein 4
Confers specificity for glucose/mannose-type carbohydrates
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Glycerol-3-phosphate dehydrogenase, mitochondrial
WD repeat-containing and planar cell polarity effector protein fritz homolog
5'-AMP-activated protein kinase subunit beta-1
In isoform 2, isoform 4, isoform 5 and isoform 6.
Turns CAST from an inhibitor into a substrate.
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Protein kinase C and casein kinase substrate in neurons 2 protein
FHF complex subunit HOOK interacting protein 1B
Major facilitator superfamily domain-containing protein 3
G protein-coupled receptor associated sorting protein 3
Keratin, type II cytoskeletal 2 epidermal
Decreases phosphorylation-dependent actin binding.
Decreases strongly phosphorylation-dependent actin binding.
Does not decrease phosphorylation-dependent actin binding.
CDGSH iron-sulfur domain-containing protein 1
Increased microtubule stability but no effect on neurite length; when associated with A-62.
Increased microtubule stability but no effect on neurite length; when associated with A-73.
Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-62.
Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-73.
Transmembrane O-methyltransferase homolog
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.08.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.12.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.13.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.15.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.16.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.19.
Triggering receptor expressed on myeloid cells 1
Tyrosine-protein phosphatase non-receptor type 11
Glycosylation-dependent cell adhesion molecule 1
Loss of kinase activity, disruption of cleavage furrow formation, failure of cytokinesis leading to cell polyploidy death.
Chloride intracellular channel protein 1
Radical S-adenosyl methionine domain-containing protein 2
Histone-lysine N-methyltransferase PRDM9
Phosphotyrosine; by SRC and autocatalysis
Propionyl-CoA carboxylase alpha chain, mitochondrial
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Calcium-independent phospholipase A2-gamma
Leucine-rich repeat-containing protein 14
PHD finger-like domain-containing protein 5A
Cytochrome c oxidase assembly protein COX14
Cell growth regulator with EF hand domain protein 1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Leucine-rich repeat transmembrane neuronal protein 2
STE20-related kinase adapter protein alpha
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
GRIP and coiled-coil domain-containing protein 2
Coiled-coil domain-containing protein 43
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
3 beta-hydroxysteroid dehydrogenase type 7
Sperm-tail PG-rich repeat-containing protein 2
Sodium-dependent organic anion transporter
Uncharacterized protein C11orf24 homolog
Glutamate-rich WD repeat-containing protein 1
Oligosaccharyltransferase complex subunit OSTC
S-adenosylmethionine synthase isoform type-2
Arachidonate 5-lipoxygenase-activating protein
Secretory carrier-associated membrane protein 5
Decreases the catalytic efficiency toward menadione and nitrobenzene substrates.
Decreases the catalytic efficiency toward menadione. Has no effect on the catalytic efficiency toward nitrobenzene substrate.
Has no effect on the catalytic efficiency toward menadione and nitrobenzene substrates.
Has no effect on the catalytic efficiency toward menadione. Slightly decreases the catalytic efficiency toward nitrobenzene substrate.
Induces a very low catalytic efficiency.
Endocytosis-deficient. When transfected in pyramidal neurons transfected, increases the rate of spine elimination and reduction in the stability of preexisting spines, compared to the wild-type protein. No effect on spine growth rate.
When expressed in pyramidal neurons, increases spine stability and reduces spine elimination.
Dimethylaniline monooxygenase [N-oxide-forming] 4
Abolishes cleavage by caspase-3 and subsequent induction of apoptosis.
Abolishes palmitoylation. Impairs interaction with DAPK1. No effect on location on lipid rafts.
Regulator of microtubule dynamics protein 3
Glycerophosphocholine cholinephosphodiesterase ENPP6
glycerophosphocholine cholinephosphodiesterase
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Tartrate-resistant acid phosphatase type 5
Calcium-binding mitochondrial carrier protein SCaMC-2
LHFPL tetraspan subfamily member 1 protein
2-oxoglutarate dehydrogenase complex component E1
Regulator of microtubule dynamics protein 2
Tissue-type plasminogen activator chain A
Tissue-type plasminogen activator chain B
Aspartate beta-hydroxylase domain-containing protein 2
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Alpha/beta hydrolase domain-containing protein 17C
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Conserved oligomeric Golgi complex subunit 7
Ig-like V-type domain-containing protein FAM187A
Approximately 5-fold decrease in Vmax for (R,S)-mevalonate. Approximately 3-fold increase in KM for (R,S)-mevalonate.
Induce significant secondary structural change.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Abolishes heme-binding but does not affect reductase activity.
Leucine zipper transcription factor-like protein 1
Solute carrier family 2, facilitated glucose transporter member 4
Retinoid-inducible serine carboxypeptidase
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Phosphatidylinositol 3-kinase catalytic subunit type 3
Insulin-like growth factor-binding protein 4
Class E basic helix-loop-helix protein 40
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1, SUMO2 and SUMO3)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1, SUMO2 and SUMO3); alternate
Decreased interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import.
Loss of homodimerization. Decreased interaction with GDP-bound RAN. Decreased interaction with nucleoporins. Decreased localization to the nuclear pore complex.
Loss of interaction with GDP-bound RAN. Loss of GDP-bound RAN nuclear import.
Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Decreased proteins nuclear import.
Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Loss of GDP-bound RAN and other proteins nuclear import.
Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Loss of proteins nuclear import.
No effect on homodimerization. Decreased interaction with GDP-bound RAN. Loss of interaction with nucleoporins and localization to the nuclear pore complex.
No effect on homodimerization. Loss of interaction with GDP-bound RAN. Decreased interaction with nucleoporins and localization to the nuclear pore complex.
No effect on interaction with GDP-bound RAN. Decreased interaction with nucleoporins. Decreased localization to the nuclear pore complex. Decreased GDP-bound RAN and other proteins nuclear import.
No effect on interaction with GDP-bound RAN. Increases GDP-bound RAN nuclear import. Increased interaction with nucleoporins and localization to the nuclear pore complex. Inhibits the nuclear import of nuclear localization signal-containing proteins.
No effect on interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import.
Protein phosphatase 1 regulatory subunit 1A
Cystic fibrosis transmembrane conductance regulator
Branched-chain-amino-acid aminotransferase, cytosolic
Vacuolar protein-sorting-associated protein 25
Decrease in PCDH8-binding; alone or when associated with G-741.
Decrease in PCDH8-binding; when associated with P-740.
Palmitoyl-protein thioesterase ABHD10, mitochondrial
ADP-ribose pyrophosphatase, mitochondrial
Calcium and integrin-binding family member 2
Probable ATP-dependent RNA helicase DDX4
Loss of inhibition by apamin and the organic molecule blockers UCL 1684 and d-tubocurarine. No effect on inhibition by tetraethylammonium (TEA).
Reduced inhibition by apamin but binding to apamin is unaffected.
Small conductance calcium-activated potassium channel protein 2
Signal transducer and activator of transcription 5A
Vacuolar protein sorting-associated protein 33B
Carbohydrate-responsive element-binding protein
Impaired DNA-binding and fatty acid sensitivity.
Inter-alpha-trypsin inhibitor light chain
Nuclear receptor subfamily 2 group C member 1
Amiloride-sensitive sodium channel subunit alpha
Changes function of the channel including conductance, gating, selectivity and voltage dependence.
Abolishes in vitro phosphorylation by PRKDC. Impairs transcriptional activation; when associated with A-280.
Constitutive active. Abolishes phosphorylation by PKB/AKT1; inhibits nuclear export; no effect on DNA binding.
Impairs transcriptional activation; when associated with A-283.
Inhibits nuclear export; when associated with A-110.
Inhibits nuclear export; when associated with A-113.
High affinity nerve growth factor receptor
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Abolishes activation of serine/threonine-protein kinase activity and only basal activity remains.
Induces an increase of the basal serine/threonine-protein kinase activity.
Probable UDP-sugar transporter protein SLC35A4
Bone morphogenetic protein receptor type-1A
Platelet-activating factor acetylhydrolase IB subunit alpha
In isoform 2, isoform 6, isoform 7 and isoform 8.
In isoform 4, isoform 5, isoform 7 and isoform 8.
Rap guanine nucleotide exchange factor 3
Striated muscle-specific serine/threonine-protein kinase
Low-density lipoprotein receptor-related protein 1 515 kDa subunit
Low-density lipoprotein receptor-related protein 1 85 kDa subunit
Low-density lipoprotein receptor-related protein 1 intracellular domain
Prolow-density lipoprotein receptor-related protein 1
Probable inactive ribonuclease-like protein 12
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
cAMP-dependent protein kinase type II-alpha regulatory subunit
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Histo-blood group ABO system transferase 2
Decreased transcription factor activity. Strongly decreased transcription factor activity; when associated with A-285.
Decreased transcription factor activity. Strongly decreased transcription factor activity; when associated with R-293.
Increases interaction with TFDP1 and TFDP2, reduces DNA-binding, transactivation activity and represses E2F1:TFDP1-mediated transcription, loss of cell cycle inhibition and adipogenesis induction.
Increases interaction with TFDP1 and TFDP2, reduces transactivation activity and represses E2F1:TFDP1-mediated transcription, loss of cell cycle inhibition and adipogenesis induction, no effect on DNA-binding; when associated with A-294.
Increases interaction with TFDP1 and TFDP2, reduces transactivation activity and represses E2F1:TFDP1-mediated transcription, loss of cell cycle inhibition and adipogenesis induction, no effect on DNA-binding; when associated with A-297.
Isoform 4: Stimulates nucleolar retention of isoform 4. No effect on interaction with NPM1, TAF1A and UBTF.
Loss of DNA-binding and transcription factor activity.
No effect neither on interaction with TFDP1 or TFDP2 nor on transactivation activity or repression of E2F1:TFDP1-mediated transcription, no effect on cell cycle inhibition or adipogenesis; when associated with A-301.
No effect neither on interaction with TFDP1 or TFDP2 nor on transactivation activity or repression of E2F1:TFDP1-mediated transcription, no effect on cell cycle inhibition or adipogenesis; when associated with A-304.
No effect on DNA-binding and transcription factor activity, but modified sequence specificity.
No effect on repression of E2F1:TFDP1-mediated transcription, no effect on cell cycle inhibition or adipogenesis; when associated with A-287.
No effect on repression of E2F1:TFDP1-mediated transcription, no effect on cell cycle inhibition or adipogenesis; when associated with A-290.
Not sumoylated. No effect of sumoylation on cell cycle inhibition.
Neuromedin U precursor-related peptide 33.
Neuromedin U precursor-related peptide 36, oxidized.
Neuromedin U precursor-related peptide 36.
Regulating synaptic membrane exocytosis protein 4
Hepatocyte growth factor-regulated tyrosine kinase substrate
Heterogeneous nuclear ribonucleoprotein M
Cytoplasmic dynein 1 light intermediate chain 1
Protein phosphatase 1 regulatory subunit 36
Loss of deubiquitinating activity and ability to promote VCP-mediated Golgi membrane fusion.
Janus kinase and microtubule-interacting protein 1
T-cell-specific surface glycoprotein CD28
Lethal(3)malignant brain tumor-like protein 2
Pyroglutamylated RF-amide peptide receptor
Decrease in the level of phosphorylation. Strong decrease in the level of phosphorylation; when associated with D-1392.
Leucine-rich repeat-containing protein 7
Strong decrease in the level of phosphorylation; when associated with D-1288.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Inhibits binding to HRAS by 19% and phospholipase stimulation by HRAS by 30%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 86%; when associated with A-2150.
Inhibits binding to HRAS by 59% and phospholipase stimulation by HRAS by 51%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 86%; when associated with A-2152.
Inhibits binding to HRAS by 67% and phospholipase stimulation by HRAS by 47%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 94%; when associated with E-2150.
Inhibits binding to HRAS by 99% and phospholipase stimulation by HRAS by 94%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 94%; when associated with E-2152.
Long-chain fatty acid transport protein 2
Interchain (with C-33 in TGFB1); in linked form
Latent-transforming growth factor beta-binding protein 1
SXIP motif 1; mediates interaction with MAPRE1 and targeting to microtubule plus ends
SXIP motif 2; mediates interaction with MAPRE1 and targeting to microtubule plus ends
Loss of phosphatidylinositol transfer activity but no significant effect on phosphatidylcholine transfer activity.
No significant effect on phosphatidylinositol and phosphatidylcholine transfer activity.
Phosphatidylinositol transfer protein alpha isoform
Reduced phosphatidylinositol and phosphatidylcholine transfer activity.
Putative protein-lysine deacylase ABHD14B
Staphylococcal nuclease domain-containing protein 1
DNA-directed RNA polymerase II subunit RPB7
Ganglioside-induced differentiation-associated-protein 2
Armadillo repeat-containing X-linked protein 3
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Abolishes interaction with DPM1; when associated with L-21.
Abolishes interaction with DPM1; when associated with S-23.
Dolichol phosphate-mannose biosynthesis regulatory protein
Transient receptor potential cation channel subfamily V member 5
Killer cell lectin-like receptor subfamily B member 1F
ATP-binding cassette sub-family F member 1
Guanine nucleotide-binding protein subunit beta-5
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Iron-sulfur clusters transporter ABCB7, mitochondrial
Lysosomal amino acid transporter 1 homolog
Minichromosome maintenance domain-containing protein 2
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Electron transfer flavoprotein subunit alpha, mitochondrial
Haloacid dehalogenase-like hydrolase domain-containing protein 2
Immediate early response 3-interacting protein 1
Potassium voltage-gated channel subfamily C member 4
A-kinase anchor protein 1, mitochondrial
7-methylguanosine phosphate-specific 5'-nucleotidase
Voltage-dependent T-type calcium channel subunit alpha-1H
Loss of nuclear localization and loss of apoptosis induction.
Mitochondrial import inner membrane translocase subunit Tim13
Translocon-associated protein subunit beta
Leucine-rich PPR motif-containing protein, mitochondrial
Loss of one manganese ion and strongly reduced catalytic activity.
Reduced affinity for arginine and reduced catalytic activity.
Reduced catalytic activity. No effect on manganese binding.
Reduced manganese binding and strongly reduced catalytic activity.
Strongly reduced catalytic activity. Minor effect on affinity for arginine.
G protein-activated inward rectifier potassium channel 2
Splicing factor, suppressor of white-apricot homolog
Loss of pH-sensitivity of estrone 3-sulfate transport.
Solute carrier organic anion transporter family member 1A1
Loss of chloride-activated potassium channel activity. Loss of potassium selectivity. Inhibited by chloride. Expression in primary dorsal root ganglion neurons induces membrane hyperexcitability and neuronal toxicity.
Gamma-aminobutyric acid receptor subunit alpha-6
Abolishes cytokine-stimulating activity; no effect on chemoattractant activity; impaired nuclear and enhanced cytoplasmic localization, retained activity in autophagy regulation.
Disrupts association with chromatin; when associated A-103 and A-122.
Disrupts association with chromatin; when associated A-38 and A-103.
Disrupts association with chromatin; when associated A-38 and A-122.
Disrupts interaction with TLR4:LY96 receptor complex and abolishes TNF release from macrophages.
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
No effect on nuclear localization. Decreases interaction with BCN1 and impairs autophagy induction. Abolishes cytokine-stimulating activity and no effect on chemoattractant activity; when associated with S-23.
No effect on nuclear localization. Decreases interaction with BCN1 and impairs in autophagy induction. Abolishes cytokine-stimulating activity and no effect on chemoattractant activity; when associated with S-45.
Partial cytoplasmic localization (mimicks acetylation); when associated with 181-Q--Q-183.
Partial cytoplasmic localization (mimicks acetylation); when associated with 27-Q--Q-29.
Partial cytoplasmic localization; when associated with 181-A--A-183.
Partial cytoplasmic localization; when associated with 27-A--A-29.
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Solute carrier organic anion transporter family member 3A1
CaM kinase-like vesicle-associated protein
Gamma-aminobutyric acid receptor subunit gamma-2
Impairs translocation from the cytoplasm to the nucleus upon glucose stimulation.
Kinase D-interacting substrate of 220 kDa
Loss of binding to PDZ domain of SNTA1 and SNTB2.
ADP-ribosylation factor GTPase-activating protein 1
Required for drug-induced death protein 1
Zinc finger C2HC domain-containing protein 1C
Eukaryotic translation initiation factor 3 subunit C
Glutamate receptor-interacting protein 2
Mas-related G-protein coupled receptor member A
Eukaryotic translation initiation factor 1A
Ras-specific guanine nucleotide-releasing factor 2
TLR4 interactor with leucine rich repeats
Vacuolar protein sorting-associated protein 54
Endosomal/lysosomal proton channel TMEM175
ATP-binding cassette sub-family C member 5
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Chloride intracellular channel protein 5
Uncharacterized protein C12orf60 homolog
Eukaryotic translation initiation factor 3 subunit H
Dihydroorotate dehydrogenase (quinone), mitochondrial
35-fold decrease in inhibition of PP1-alpha.
Eukaryotic translation initiation factor 3 subunit G
POU domain, class 4, transcription factor 3
Hsp90 co-chaperone Cdc37, N-terminally processed
N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processed
Leptin receptor overlapping transcript-like 1
NEDD8-activating enzyme E1 catalytic subunit
Abolishes calcium binding, lowering of binding to myotubes and some loss of AChR clustering activity; when associated with A-1831.
Abolishes calcium binding, lowering of binding to myotubes and some loss of AChR clustering activity; when associated with A-1900.
Abolishes chondroitin sulfate (CS) binding, greatly reduced branched retraction fiber (BRF) formation, filopodia formation reduced by about 50% and lowered RAC1 and CDK1 activation. No chondroitin sulfate (CS) nor heparan sulfate (HS) binding almost no retraction fiber (BRF) formation, filopodia formation reduced by about 60% lowered RAC1 and CDK1 activation; when associated with 566-AGGAGA-571.
Abolishes formation of AGRN-LRP4 complex and MUSK activation.
Abolishes formation of AGRN-LRP4 complex and MUSK activation. No AChR clustering activity.
Abolishes fucosylation of muscle agrin. Stimulates MUSK phosphorylation and increases AChR clustering.
Abolishes heparan sulfate (HS) binding, greatly reduced branched retraction fiber (BRF) formation, filopodia formation reduced by about 50% and lowered RAC1 and CDK1 activation. No chondroitin sulfate (CS) nor heparan sulfate attachment, almost no branched retraction fiber (BRF) formation, filopodia formation reduced by about 60% and lowered RAC1 and CDK1 activation; when associated with 953-AGA-955.
About 13% reduction in cleavage by neurotrypsin.
About 20% reduction in cleavage by neurotrypsin.
About 23% reduction in cleavage by neurotrypsin. Reduces cleavage by neurotrypsin by about 90%; when associated with A-1752. Completely abolishes cleavage by neurotrypsin; when associated with A-1753.
About 30% reduction in cleavage by neurotrypsin.
About 41% reduction in cleavage by neurotrypsin. Reduces cleavage by neurotrypsin by about 90%; when associated with A-1751. Completely abolishes cleavage by neurotrypsin; when associated with A-1753.
About 55% reduction in cleavage by neurotrypsin.
About 60% reduction in cleavage by neurotrypsin.
About 62% reduction in cleavage by neurotrypsin.
About 64% reduction in cleavage by neurotrypsin.
Almost completely abolishes cleavage by neurotrypsin.
Almost completely abolishes cleavage by neurotrypsin. Completely abolishes cleavage by neurotrypsin; when associated with A-1751 or A-1752.
Completely abolishes cleavage by neurotrypsin.
No effect formation of AGRN-LRP4 complex nor on MUSK activation.
No effect on formation of AGRN-LRP4 complex nor on MUSK activation.
Significant reduction in AChR clustering ability.
Slight reduction in AChR clustering ability.
Slight reduction in AChR clustering ability. Slight reduction in AChR clustering ability.
Slight reduction in cleavage by neurotrypsin.
Constitutive interaction with p115/USO1; under mitotic as well as interphase conditions.
Does not affect interaction with p115/USO1.
Impairs interaction with GORASP1/GRASP65.
Phosphomimetic mutant that strongly reduces interaction with p115/USO1.
Strongly impairs interaction with GORASP1/GRASP65.
Plasminogen activator inhibitor 1 RNA-binding protein
Heparan sulfate glucosamine 3-O-sulfotransferase 1
Decreases lanosterol 14-alpha demethylase activity.
Decreases lanosterol 14-alpha demethylase activity. Increases the susceptibility to ketoconazole.
Impairs lanosterol 14-alpha demethylase activity.
Impairs lanosterol 14-alpha demethylase activity. Increases the susceptibility to ketoconazole.
Significatly decreases lanosterol 14-alpha demethylase activity.
Significatly decreases lanosterol 14-alpha demethylase activity. Increases the susceptibility to ketoconazole.
Uncharacterized protein KIAA0930 homolog
Matrix extracellular phosphoglycoprotein
Tumor-associated calcium signal transducer 2
Increases basal level of enzyme activity. Abolishes activation by PKC; when associated with D-490.
Increases basal level of enzyme activity. Abolishes activation by PKC; when associated with D-543.
Reduces activation by PKC. Abolishes activation by PKC; when associated with A-490.
Reduces activation by PKC. Abolishes activation by PKC; when associated with A-543.
Strongly decreased sensitivity to glutamate.
Calcium-activated potassium channel subunit beta-3
Mas-related G-protein coupled receptor member B5
Serine/threonine-protein phosphatase CPPED1
Voltage-dependent calcium channel gamma-like subunit
Cyclic AMP-responsive element-binding protein 1
Loss of phosphorylation by CaMK2. Activation by CaMK2.
Phosphoserine; by CaMK1, CaMK2, CaMK4, PKB/AKT1 or PKB/AKT2, RPS6KA3, RPS6KA4, RPS6KA5 and SGK1
Actin-related protein 2/3 complex subunit 1B
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Does not affect epimerase activity; does not affect feedback inhibition by CMP-Neu5Ac; almost complete loss of kinase activity; does not interfere with oligomerization.
Does not affect kinase activity; almost complete loss of epimerase activity; does not interfere with enzyme oligomerization.
Does not affect kinase activity; almost complete loss of epimerase activity; partial reduction of the dimerization process.
Does not affect kinase activity; almost complete loss of epimerase activity; strong reduction of the dimerization process.
Proprotein convertase subtilisin/kexin type 4
Platelet-derived growth factor C, latent form
Platelet-derived growth factor C, receptor-binding form
Receptor-binding cancer antigen expressed on SiSo cells
In isoform 1, isoform 2, isoform 3, isoform 5 and isoform 6.
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Probable mitochondrial glutathione transporter SLC25A40
Transmembrane and ubiquitin-like domain-containing protein 1
Brain-specific angiogenesis inhibitor 1-associated protein 2
Loss of phosphorylation; when associated with F-115 and F-178.
Loss of phosphorylation; when associated with F-17 and F-115.
Loss of phosphorylation; when associated with F-17 and F-178.
Pre-B-cell leukemia transcription factor-interacting protein 1
Cilia- and flagella-associated protein 20
Mitochondrial import inner membrane translocase subunit Tim21
BoNT/E not taken up by mouse SV2A/SV2B knockout neurons, decreased uptake of BoNT/A; SV2A apparent molecular weight decreases. No change in uptake of BoNT/D.
N-linked (HexNAc...) asparagine; alternate
No change in uptake of BoNT/D or BoNT/E.
No change in uptake of BoNT/E or BoNT/A by mouse SV2A/SV2B knockout neurons; SV2A apparent molecular weight decreases. No change in uptake of BoNT/E; when associated with Q-498. No change in uptake of BoNT/D.
No change in uptake of BoNT/E or C.botulinum neurotoxin type A (BoNT/A, botA) by mouse SV2A/SV2B knockout neurons; SV2A apparent molecular weight decreases. No change in uptake of BoNT/E; when associated with Q-548. No change in uptake of BoNT/D.
No change in uptake of C.botulinum neurotoxin type D (BoNT/D, botD) or C.botulinum neurotoxin type E (BoNT/E).
Restores apparent molecular weight to wild-type, does not restore uptake of BoNT/E.
Arf-GAP domain and FG repeat-containing protein 1
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
FXYD domain-containing ion transport regulator 6
Carnitine O-palmitoyltransferase 2, mitochondrial
Deleted in malignant brain tumors 1 protein
L-serine dehydratase/L-threonine deaminase
Loss of catalytic activity and loss of covalent substrate binding.
Loss of catalytic activity and severe reduction in substrate binding.
ATP synthase subunit beta, mitochondrial
Dual specificity mitogen-activated protein kinase kinase 2
G-protein coupled receptor family C group 6 member A
Activated RNA polymerase II transcriptional coactivator p15
Electrogenic sodium bicarbonate cotransporter 4
Nuclear factor of activated T-cells, cytoplasmic 4
Amyloid-beta A4 precursor protein-binding family A member 2
Natural resistance-associated macrophage protein 2
Proton acceptor; for glutaminase activity
Gamma-aminobutyric acid receptor subunit gamma-1
Queuine tRNA-ribosyltransferase catalytic subunit 1
Mitochondrial import receptor subunit TOM70
Ubiquitin carboxyl-terminal hydrolase 30
ATP synthase subunit alpha, mitochondrial
Isopentenyl-diphosphate Delta-isomerase 1
Abolishes phosphorylation by MAPK1; when associated with A-1178 and A-1187.
Abolishes phosphorylation by MAPK1; when associated with A-1178 and A-1267.
Abolishes phosphorylation by MAPK1; when associated with A-1187 and A-1267.
Leucine-rich repeat and IQ domain-containing protein 3
Cytoplasmic dynein 1 light intermediate chain 2
Sodium-dependent phosphate transporter 2
Lowers activity towards medium and long chain fatty acids. Increases activity towards short chain fatty acids.
Peroxisomal carnitine O-octanoyltransferase
Reduces activity by 80%. No effect on inhibition by malonyl-coenzyme A.
Succinate dehydrogenase assembly factor 3, mitochondrial
7-fold increase of the binding constant for lauric acid associated with higher catalytic activity. 2-fold increase of omega/omega-1 hydroxylation ratio for lauric and myristic acids; when associated with S114_I116del.
70-fold increase of the binding constant for lauric acid associated with higher catalytic activity.
Has no significant effect on the catalytic activity toward lauric and myristic acids.
Higher kcat for hydroxylation of lauric acid. 2-fold increase of omega/(omega-1) hydroxylation ratio for lauric and myristic acids; when associated with S-119.
Significant reduction in covalent heme binding.
Lymphocyte antigen 6 complex locus protein G6f
Coiled-coil domain-containing protein 146
Tumor protein p53-inducible nuclear protein 1
Apically localized. Loss of PRKCA-dependent cell motility.
Localized to the lamellipodia. Increases cell motility independently of PRKCA activation.
No chondroitin sulfate attachment. Loss of localization to the retraction fibers.
No effect on chondroitin sulfate attachment.
Leucine-rich repeat transmembrane protein FLRT2
Platelet-derived growth factor receptor-like protein
Alpha-aminoadipic semialdehyde dehydrogenase
Lysosomal cobalamin transport escort protein LMBD1
WTKF motif; mediates interaction with adapter protein complex 2 and is essential for its function in clathrin-mediated endocytosis of INSR
YERL motif; mediates interaction with adapter protein complex 2 and is essential for its function in clathrin-mediated endocytosis of INSR
Increased affinity for serotonin and tyramine.
Coiled-coil domain-containing protein 127
Opioid growth factor receptor-like protein 1
Loss of phosphorylation and strong reduction of activity.
Loss of phosphorylation; No inhibition of activity.
Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3
Circadian locomoter output cycles protein kaput
Cilia- and flagella-associated protein 36
Abolishes interaction with KCNAB2 and strongly reduces cell surface expression. No effect phosphorylation in response to increased cAMP levels.
Alters voltage-sensitive channel opening.
Changes channel gating from a predominantly slow mode to a much more rapid mode.
Confers sensitivity to inhibition by tetraethylammonium (TEA).
Impairs N-glycosylation and abolishes expression at the cell surface.
Impairs protein folding. Loss of tetramerization.
In paddle chimera; changes channel activation to less negative voltage values and renders the channel susceptible to inhibition by the spider toxin VsTx1.
Nearly abolishes interaction with CTTN; when associated with F-415. Strongly reduces channel activity.
Nearly abolishes interaction with CTTN; when associated with F-417.
No effect on N-glycosylation. Abolishes channel activity of the homotetramer, but retains channel activity in the presence of a beta subunit.
No effect on tetramerization. Alters voltage-sensitive channel opening.
Potassium voltage-gated channel subfamily A member 2
Strongly reduces cell surface expression. Abolishes phosphorylation in response to increased cAMP levels.
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Breast cancer metastasis-suppressor 1 homolog
Gamma-aminobutyric acid type B receptor subunit 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
General transcription and DNA repair factor IIH helicase subunit XPB
Decreased binding to GNAI3 and impaired GNAI3 activation.
Decreased binding to GNAI3. Further decrease in binding to GNAI3 and loss of GNAI3 activation; when associated with A-313.
Decreased binding to GNAI3. Further decrease in binding to GNAI3 and loss of GNAI3 activation; when associated with A-317.
Receptor-type tyrosine-protein phosphatase alpha
U3 small nucleolar RNA-associated protein 15 homolog
V-type proton ATPase 16 kDa proteolipid subunit c
Leucine-rich repeat-containing protein 46
Linker for activation of T-cells family member 1
Serine palmitoyltransferase small subunit A
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Thioredoxin-dependent peroxide reductase, mitochondrial
Uncharacterized protein KIAA1143 homolog
Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-111 and A-119.
Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-111 and A-131. Reduces transcriptional repressor activity; when associated with A-31 and A-111.
Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-119 and A-131. Reduces transcriptional repressor activity; when associated with A-31 and A-119.
Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-111; A-119 and A-131.
Abolishes binding to YWHAB. Reduces transcriptional repressor activity; when associated with A-111 and A-119.
Vacuolar protein sorting-associated protein 29
Alters interaction with COPB1 but not with SEC24C.
Prevents phosphorylation by ABL1 and impairs transport from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment.
Speckle targeted PIP5K1A-regulated poly(A) polymerase
Coiled-coil domain-containing protein 71
Abolishes lipid binding; when associated with L-63.
Strongly reduces lipid binding. Abolishes lipid binding; when associated with L-73.
Patatin-like phospholipase domain-containing protein 2
Interferon-related developmental regulator 1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
Reduces affinity for substrate 20-fold, and decreases affinity for the competitive inhibitor fructose 2,6-bisphosphate 500-fold.
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Alternate; transient; in hyperoxia; unknown whether inter- or intrachain
Cysteine sulfenic acid (-SOH); transient; in hyperoxia
Transient receptor potential cation channel subfamily A member 1
Coiled-coil domain-containing protein 50
Dual specificity mitogen-activated protein kinase kinase 7
39S ribosomal protein L46, mitochondrial
Sodium- and chloride-dependent transporter XTRP3
Phosphatidylinositol 4-kinase type 2-beta
Signal transducer and activator of transcription 5B
tRNA N(3)-methylcytidine methyltransferase METTL6
Outer dynein arm-docking complex subunit 1
Telomeric repeat-binding factor 2-interacting protein 1
V-set domain-containing T-cell activation inhibitor 1
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
5-glutamyl glycerylphosphorylethanolamine
N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT3
Coiled-coil domain-containing protein 172
Microtubule-associated tyrosine carboxypeptidase
Glycerol-3-phosphate acyltransferase 2, mitochondrial
Tubulointerstitial nephritis antigen-like
Primary cilium assembly protein FAM149B1
Cytosolic acyl coenzyme A thioester hydrolase
ATP-binding cassette subfamily C member 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Platelet-derived growth factor receptor alpha
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Does not affect interaction with NSF and ability to dissociate NSF from GRIA2.
Mimicks phosphorylation state, leading to increased activity.
Leucine-rich repeat-containing protein 59
Leucine-rich repeat-containing protein 59, N-terminally processed
N-acetylthreonine; in Leucine-rich repeat-containing protein 59, N-terminally processed
Abolishes rescue of lipase-deficient activity in Pnliprp2 knockout neurons.
Coiled-coil domain-containing glutamate-rich protein 1
Sterile alpha motif domain-containing protein 14
10-fold decrease in activity of the spider RTX-VII toxin.
12-fold decrease in activity of the spider RTX-VII toxin.
2-fold decrease in activity of the spider RTX-VII toxin.
20-fold decrease in activity of the spider RTX-VII toxin.
4.5-fold decrease in activity of the spider RTX-VII toxin.
5.5-fold decrease in activity of the spider RTX-VII toxin.
6-fold decrease in activity of the spider RTX-VII toxin.
Sodium channel protein type 3 subunit alpha
Guanine nucleotide-binding protein G(i) subunit alpha-2
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; G-96; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; G-112 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112 and T-121. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; G-112 and T-121.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with I-82 and A-85.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with I-82 and A-111.
Increases sensitivity to RGS14 GTPase activity; when associated with I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with I-85 and A-111.
Solute carrier family 2, facilitated glucose transporter member 5
Peptidyl-prolyl cis-trans isomerase FKBP8
Nuclear receptor subfamily 0 group B member 1
Glutaminase kidney isoform, mitochondrial 65 kDa chain
Glutaminase kidney isoform, mitochondrial 68 kDa chain
Guanine nucleotide exchange factor for Rab-3A
Transcription initiation factor IIA subunit 2
Class A basic helix-loop-helix protein 15
Does not abolish channel activity inhibition in presence of nitric oxide (NO); when associated with A-564. Absence of channel activity inhibition in presence of cAMP; when associated with A-563.
Does not abolish channel activity inhibition in presence of nitric oxide (NO); when associated with A-564. Absence of channel activity inhibition in presence of cAMP; when associated with A-564.
Potassium voltage-gated channel subfamily C member 2
Insulin-like growth factor-binding protein 5
Changes active site geometry and alters affinity for NAD.
Strongly reduces S-adenosyl-L-homocysteine hydrolase activity.
Voltage-dependent calcium channel gamma-5 subunit
Stress-associated endoplasmic reticulum protein 1
PAXIP1-associated glutamate-rich protein 1
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein G; alternate
N-acetylvaline; in Heterogeneous nuclear ribonucleoprotein G, N-terminally processed
RNA-binding motif protein, X chromosome, N-terminally processed
Epidermal growth factor receptor kinase substrate 8
Iron-responsive element-binding protein 2
SH3 domain-containing kinase-binding protein 1
Glucose-6-phosphatase catalytic subunit 1
Abolishes phosphatidylinisitol binding, no translocation to the cell membrane, and no effect on phosphorylation of AKT1 nor IRS1.
Decreased TRAK1 O-glycosylation by this protein.
Decreased ability to reduce neuronal mitochondrial motility in both anterograde and retrograde directions.
Loss of glycosylation activity. Loss of ability to reduce mitochondrial motility.
No effect on phosphatidylinisitol binding.
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Wild-type O-GlcNAc transferase activity, does not form trimers.
Wild-type O-GlcNAc transferase activity, forms trimers.
28 kDa heat- and acid-stable phosphoprotein
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Leucine-rich repeat-containing protein 18
SH3-containing GRB2-like protein 3-interacting protein 1
Calcium/calmodulin-dependent protein kinase type 1G
Impaired internalization after somatostatin binding.
Reduced basal and somatostatin-induced phosphorylation. Impaired internalization after somatostatin binding.
N-acetylthreonine; in Ubiquitin-conjugating enzyme E2 G1, N-terminally processed
Ubiquitin-conjugating enzyme E2 G1, N-terminally processed
Nicotinate-nucleotide pyrophosphorylase [carboxylating]