Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct annotated encoding genes.
Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.
A conserved dimer and global conformational changes in the structure of apo-PknE Ser/Thr protein kinase from Mycobacterium tuberculosis.
Characterization of the phosphorylation sites of Mycobacterium tuberculosis serine/threonine protein kinases, PknA, PknD, PknE, and PknH by mass spectrometry.
Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.
Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains.
PknE, a serine/threonine protein kinase from Mycobacterium tuberculosis has a role in adaptive responses.
Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis.
Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection.
pknE, a serine/threonine kinase of Mycobacterium tuberculosis modulates multiple apoptotic paradigms.
Lipoprotein LprI of Mycobacterium tuberculosis acts as a lysozyme inhibitor.
Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of Rv0241c (HtdX) from Mycobacterium tuberculosis H37Rv.
Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ.
Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.
Genes required for mycobacterial growth defined by high density mutagenesis.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex.
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.
A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis.
Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules.
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution.
Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein.
Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages.
Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis.
Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system.
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis.
Mycobacterium tuberculosis signal transduction system required for persistent infections.
The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.
Characterization of two genes encoding the Mycobacterium tuberculosis ribonucleotide reductase small subunit.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
Isolation of ribonucleotide reductase from Mycobacterium tuberculosis and cloning, expression, and purification of the large subunit.
Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases.
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
Activity of 3-ketosteroid 9alpha-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis.
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
Substrate specificities and conformational flexibility of 3-ketosteroid 9alpha-hydroxylases.
Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins.
Identification and characterization of a 29-kilodalton protein from Mycobacterium tuberculosis culture filtrate recognized by mouse memory effector cells.
Large-scale computational discovery and analysis of virus-derived microbial nanocompartments.
Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages.
Acta Crystallogr. F Struct. Biol. Commun.
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.
Overexpression, purification, crystallization and structure determination of AspB, a putative aspartate aminotransferase from Mycobacterium tuberculosis.
Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.
Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr gene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.
Biochemical evidence for relaxed substrate specificity of Nalpha-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis.
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.
Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis.
Mycobacterial MazG is a novel NTP pyrophosphohydrolase involved in oxidative stress response.
Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture.
An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses.
Bacterial protein reshapes host defense toward antiviral responses.
Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis.
Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis.
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis.
Interaction of Mycobacterium tuberculosis RshA and SigH is mediated by salt bridges.
Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.
RshA mimetic peptides inhibiting the transcription driven by a Mycobacterium tuberculosis sigma factor SigH.
RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH.
Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility.
Systematic genetic nomenclature for type VII secretion systems.
The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer.
A Sir2-like protein participates in mycobacterial NHEJ.
Biochemical and genetic analysis of the four DNA ligases of mycobacteria.
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D.
Domain structure of a NHEJ DNA repair ligase from Mycobacterium tuberculosis.
Identification of a DNA nonhomologous end-joining complex in bacteria.
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C.
Molecular basis for DNA double-strand break annealing and primer extension by an NHEJ DNA polymerase.
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
Mycobacteriophage exploit NHEJ to facilitate genome circularization.
Structure and function of a mycobacterial NHEJ DNA repair polymerase.
Structure of a NHEJ polymerase-mediated DNA synaptic complex.
Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase.
The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.
A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages.
Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB.
Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis.
Structural analysis of mycobacterial branched-chain aminotransferase: implications for inhibitor design.
The 1.9 A structure of the branched-chain amino-acid transaminase (IlvE) from Mycobacterium tuberculosis.
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Catabolism of the last two steroid rings in Mycobacterium tuberculosis and other bacteria.
IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.
Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc.
Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon.
IdeR, an essential gene in Mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.
The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.
The 65-kilodalton antigen of Mycobacterium tuberculosis.
Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.
Phosphofructokinases A and B from Mycobacterium tuberculosis display different catalytic properties and allosteric regulation.
Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis.
Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis.
Structure of the response regulator PhoP from Mycobacterium tuberculosis reveals a dimer through the receiver domain.
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampicin resistance, and pathogenesis.
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.
Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates.
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid.
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
Bacterial proteasome activator Bpa (Rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome.
Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.
The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.
Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.
The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB.
Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Increasing the structural coverage of tuberculosis drug targets.
Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-kappaB pathway.
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
A revised biosynthetic pathway for the cofactor F420 in prokaryotes.
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.
Reverse type I inhibitor of Mycobacteriumtuberculosis CYP125A1.
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis.
Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.
Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli.
Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.
para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.
Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria.
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.
Mycobacterium tuberculosis RsdA provides a conformational rationale for selective regulation of sigma-factor activity by proteolysis.
Expression cloning of an immunodominant family of Mycobacterium tuberculosis antigens using human CD4(+) T cells.
Molecular characterization of secretory proteins Rv3619c and Rv3620c from Mycobacterium tuberculosis H37Rv.
Mycobacterium tuberculosis RNA expression patterns in sputum bacteria indicate secreted Esx factors contributing to growth are highly expressed in active disease.
A mycobacterial extracytoplasmic function sigma factor involved in survival following stress.
Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.
Evidence of complex transcriptional, translational, and posttranslational regulation of the extracytoplasmic function sigma factor sigmaE in Mycobacterium tuberculosis.
Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.
RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis.
The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis.
The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.
Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis.
Genetic requirements for mycobacterial survival during infection.
Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2.
Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase.
The crystal structure of NusB from Mycobacterium tuberculosis.
A novel trehalase from Mycobacterium smegmatis - purification, properties, requirements.
Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.
An M. tuberculosis DNA fragment contains genes encoding cell division proteins ftsX and ftsE, a basic protein and homologues of PemK and small protein B.
Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function.
Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.
Characterization of mRNA interferases from Mycobacterium tuberculosis.
Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis.
MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs.
Noncognate Mycobacterium tuberculosis toxin-antitoxins can physically and functionally interact.
High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase.
Identification of outer membrane proteins of Mycobacterium tuberculosis.
A genetic locus required for iron acquisition in Mycobacterium tuberculosis.
Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice.
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase.
The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2.
Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence.
A multicopper oxidase is required for copper resistance in Mycobacterium tuberculosis.
The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence.
Identification of novel immunogenic Mycobacterium tuberculosis peptides that stimulate mononuclear cells from immune donors.
A novel F(420)-dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics.
Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site.
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis.
Over-expression and purification strategies for recombinant multi-protein oligomers: a case study of Mycobacterium tuberculosis sigma/anti-sigma factor protein complexes.
Transcription regulation by the Mycobacterium tuberculosis alternative sigma factor SigD and its role in virulence.
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.
EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.
EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis.
EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR.
Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis.
M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells.
MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response.
Mutually dependent secretion of proteins required for mycobacterial virulence.
Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1.
Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.
Secreted transcription factor controls Mycobacterium tuberculosis virulence.
The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis.
Biochemical investigation of Rv3404c from Mycobacterium tuberculosis.
Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence.
A family of autocrine growth factors in Mycobacterium tuberculosis.
Global expression profiling of strains harbouring null mutations reveals that the five rpf-like genes of Mycobacterium tuberculosis show functional redundancy.
The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro.
The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes.
Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Use of a "silver bullet" to resolve crystal lattice dislocation disorder: a cobalamin complex of 1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
Use of a "silver bullet" to resolve crystal lattice dislocation disorder: a cobalamin complex of Delta1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters.
Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.
M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog.
Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis.
Mycobacterium tuberculosis FurA autoregulates its own expression.
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis.
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
Structural mechanics of the pH-dependent activity of beta-carbonic anhydrase from Mycobacterium tuberculosis.
Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis.
An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death.
Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress.
Comprehensive essentiality analysis of the Mycobacterium tuberculosis genome via saturating transposon mutagenesis.
Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival.
The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+.
The enduring hypoxic response of Mycobacterium tuberculosis.
A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis.
Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate.
Mycobacterium tuberculosis isocitrate lyase (MtbIcl): role of divalent cations in modulation of functional and structural properties.
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
Role of the transcriptional regulator RamB (Rv0465c) in the control of the glyoxylate cycle in Mycobacterium tuberculosis.
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis.
A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927.
The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis.
Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect cyclic di-AMP synthesis activity in Mycobacterium smegmatis.
Novel selection for isoniazid (INH) resistance genes supports a role for NAD+-binding proteins in mycobacterial INH resistance.
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase.
Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis.
Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance.
Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS?
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase.
Alpha-methyl acyl CoA racemase provides Mycobacterium tuberculosis catabolic access to cholesterol esters.
Unraveling cholesterol catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha2beta2 acyl-CoA dehydrogenase initiates beta-oxidation of 3-oxo-cholest-4-en-26-oyl CoA.
Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase.
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
Isolation, purification and immunological characterization of novel low molecular weight protein antigen CFP 6 from culture filtrate of M. tuberculosis.
Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis.
Profiling of Mycobacterium tuberculosis gene expression during human macrophage infection: upregulation of the alternative sigma factor G, a group of transcriptional regulators, and proteins with unknown function.
Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems.
Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditions.
Individual Mycobacterium tuberculosis universal stress protein homologues are dispensable in vitro.
Role of M.tuberculosis protein Rv2005c in the aminoglycosides resistance.
Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis.
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.
In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid.
Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies.
Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change.
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.
Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding.
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms.
Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis.
Role of Serine140 in the mode of action of Mycobacterium tuberculosis beta-ketoacyl-ACP Reductase (MabA).
The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2.
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis.
Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.
Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.
Experimental determination of translational starts using peptide mass mapping and tandem mass spectrometry within the proteome of Mycobacterium tuberculosis.
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ.
Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A.
The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex.
Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family.
Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.
The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases.
The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis.
The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division.
The transpeptidase PbpA and noncanonical transglycosylase RodA of Mycobacterium tuberculosis play important roles in regulating bacterial cell lengths.
Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis.
Mycobacterium tuberculosis Des protein: an immunodominant target for the humoral response of tuberculous patients.
Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.
Insights into the substrate specificity of a thioesterase Rv0098 of Mycobacterium tuberculosis through X-ray crystallographic and molecular dynamics studies.
Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.
Composition of the type VII secretion system membrane complex.
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.
A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.
Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.
C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis.
Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.
Substrates control multimerization and activation of the multi-domain ATPase motor of type VII secretion.
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
A new family of type III polyketide synthases in Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.
Characterization of heme ligation properties of Rv0203, a secreted heme binding protein involved in Mycobacterium tuberculosis heme uptake.
Discovery and characterization of a unique mycobacterial heme acquisition system.
The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis.
Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification.
Immunological evaluation of novel Mycobacterium tuberculosis culture filtrate proteins.
Peptides derived from Mycobacterium tuberculosis Rv2301 protein are involved in invasion to human epithelial cells and macrophages.
Two-dimensional electrophoresis for analysis of Mycobacterium tuberculosis culture filtrate and purification and characterization of six novel proteins.
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis.
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
The structural basis of chain length control in Rv1086.
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.
A preclinical candidate targeting Mycobacterium tuberculosis KasA.
Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin.
Exploring the SAR of the beta-ketoacyl-ACP synthase inhibitor GSK3011724A and optimization around a genotoxic metabolite.
Identification of KasA as the cellular target of an anti-tubercular scaffold.
KasA, another brick in the mycobacterial cell wall.
Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design.
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.
Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.
Substrate recognition by beta-ketoacyl-ACP synthases.
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
The protonation state of catalytic residues in the resting state of KasA revisited: detailed mechanism for the activation of KasA by its own substrate.
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis.
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase.
Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.
Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence.
Three different putative phosphate transport receptors are encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG.
Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress.
Massive gene duplication event among clinical isolates of the Mycobacterium tuberculosis W/Beijing family.
Characterization of CrgA, a new partner of the Mycobacterium tuberculosis peptidoglycan polymerization complexes.
Mycobacterium tuberculosis CwsA interacts with CrgA and Wag31, and the CrgA-CwsA complex is involved in peptidoglycan synthesis and cell shape determination.
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria.
LytB1 and LytB2 of Mycobacterium tuberculosis are not genetically redundant.
Crystal structure of the conserved hypothetical protein Rv1155 from Mycobacterium tuberculosis.
Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis.
Rv2074 is a novel F420H2-dependent biliverdin reductase in Mycobacterium tuberculosis.
Structures of Mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate.
Kinetic and mechanistic characterization of the glyceraldehyde 3-phosphate dehydrogenase from Mycobacterium tuberculosis.
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis.
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry.
A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis.
Examination of Mycobacterium tuberculosis sigma factor mutants using low-dose aerosol infection of guinea pigs suggests a role for SigC in pathogenesis.
Genome-wide definition of the SigF regulon in Mycobacterium tuberculosis.
Interactions of the M. tuberculosis UsfX with the cognate sigma factor SigF and the anti-anti sigma factor RsfA.
Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the sigma A-containing RNA polymerase holoenzyme.
Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms.
Sigma factor F does not prevent rifampin inhibition of RNA polymerase or cause rifampin tolerance in Mycobacterium tuberculosis.
An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3.
Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis.
Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin.
The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA.
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
jefA (Rv2459), a drug efflux gene in Mycobacterium tuberculosis confers resistance to isoniazid & ethambutol.
The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria.
Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae.
The ABC transporter Rv1272c of Mycobacterium tuberculosis enhances the import of long-chain fatty acids in Escherichia coli.
Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase.
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
Characterization of Guided Entry of Tail-Anchored Proteins 3 Homologues in Mycobacterium tuberculosis.
A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis.
An immunomodulatory role for the Mycobacterium tuberculosis region of difference 1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873).
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6.
Characterization of a cross-reactive, immunodominant and HLA-promiscuous epitope of Mycobacterium tuberculosis-specific major antigenic protein PPE68.
PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family.
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis.
Cloning and characterization of GTP-binding proteins of Mycobacterium tuberculosis H37Rv.
Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG.
2-Carboxyquinoxalines kill Mycobacterium tuberculosis through noncovalent inhibition of DprE1.
Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging.
AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosis.
Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis.
Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.
Functional reconstitution of the Mycobacterium tuberculosis long-chain acyl-CoA carboxylase from multiple acyl-CoA subunits.
Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent acyl-CoA carboxylase in Mycobacterium tuberculosis H37Rv.
Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases.
Rv0100, a proposed acyl carrier protein in Mycobacterium tuberculosis: expression, purification and crystallization.
Rv0100, a proposed acyl carrier protein in Mycobacterium tuberculosis: expression, purification and crystallization. Corrigendum.
Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.
A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis.
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway.
Delineating the physiological roles of the PE and catalytic domains of LipY in lipid consumption in Mycobacterium-infected foamy macrophages.
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains.
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.
Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia.
Identification and characterization of lipase activity and immunogenicity of LipL from Mycobacterium tuberculosis.
Increased virulence of Mycobacterium tuberculosis H37Rv overexpressing LipY in a murine model.
Modulation of the activity of Mycobacterium tuberculosis LipY by its PE domain.
Type VII secretion substrates of pathogenic Mycobacteria are processed by a surface protease.
Identification of Rv3230c as the NADPH oxidoreductase of a two-protein DesA3 acyl-CoA desaturase in Mycobacterium tuberculosis H37Rv.
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.
Identification of substrates of the Mycobacterium tuberculosis proteasome.
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.
Inhibitors selective for mycobacterial versus human proteasomes.
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.
Phosphorylation regulates mycobacterial proteasome.
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure.
Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome.
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.
CtpA, a putative Mycobacterium tuberculosis P-type ATPase, is stimulated by copper (I) in the mycobacterial plasma membrane.
Identification of Mycobacterium tuberculosis genes preferentially expressed during human infection.
A novel copper-responsive regulon in Mycobacterium tuberculosis.
Lipoprotein LpqS deficient M. tuberculosis mutant is attenuated for virulence in vivo and shows protective efficacy better than BCG in guinea pigs.
The lpqS knockout mutant of Mycobacterium tuberculosis is attenuated in macrophages.
A nickel-cobalt-sensing ArsR-SmtB family repressor. Contributions of cytosol and effector binding sites to metal selectivity.
Solution structure of Mycobacterium tuberculosis NmtR in the apo state: insights into Ni(II)-mediated allostery.
Specific interaction between Mycobacterium tuberculosis lipoprotein-derived peptides and target cells inhibits mycobacterial entry in vitro.
A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis.
Characterization of an aldolase involved in cholesterol side chain degradation in Mycobacterium tuberculosis.
Mycobacterium tuberculosis exploits a heterohexameric enoyl-CoA hydratase retro-aldolase complex for cholesterol catabolism.
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis.
Structural insights into the substrate-binding proteins Mce1A and Mce4A from Mycobacterium tuberculosis.
Association of strong immune responses to PPE protein Rv1168c with active tuberculosis.
Cloning, expression, and refolding of PPE17 protein of Mycobacterium tuberculosis as a promising vaccine candidate.
PPE17 (Rv1168c) protein of Mycobacterium tuberculosis detects individuals with latent TB infection.
Proline-proline-glutamic acid (PPE) protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 long terminal repeat promoter.
The Mycobacterium tuberculosis PPE protein Rv1168c induces stronger B cell response than Rv0256c in active TB patients.
The N-terminal domain of Mycobacterium tuberculosis PPE17 (Rv1168c) protein plays a dominant role in inducing antibody responses in active TB patients.
The PPE domain of PPE17 is responsible for its surface localization and can be used to express heterologous proteins on the mycobacterial surface.
Transduction of functionally contrasting signals by two Mycobacterial PPE proteins downstream of TLR2 receptors.
Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.
Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance.
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.
The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis.
ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.
Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis.
Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation.
Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.
X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction.
A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa.
Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes.
Prokaryotic ubiquitin-like protein (Pup) is coupled to substrates via the side chain of its C-terminal glutamate.
Prokaryotic ubiquitin-like protein Pup is intrinsically disordered.
Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates.
Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein.
The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus.
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.
A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis.
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis.
Crystallization and preliminary X-ray analysis of NAD kinase from Mycobacterium tuberculosis H37Rv.
Crystallographic studies of Mycobacterium tuberculosis polyphosphate/ATP-NAD kinase complexed with NAD.
Inorganic polyphosphate / ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv.
NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex.
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis.
Rv0132c of Mycobacterium tuberculosis encodes a coenzyme F420-dependent hydroxymycolic acid dehydrogenase.
Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis.
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
Lansoprazole is an antituberculous prodrug targeting cytochrome bc1.
Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK.
Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis.
Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module.
Characterization of a novel esterase Rv1497 of Mycobacterium tuberculosis H37Rv demonstrating beta-lactamase activity.
A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis.
Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis.
Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis.
Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs.
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.
Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.
Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).
Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.
MptpB promotes mycobacteria survival by inhibiting the expression of inflammatory mediators and cell apoptosis in macrophages.
MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity.
Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site.
Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development.
Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.
Structural insights into mode of actions of novel natural Mycobacterium protein tyrosine phosphatase B inhibitors.
Structure-based design of MptpB inhibitors that reduce multidrug-resistant Mycobacterium tuberculosis survival and infection burden in vivo.
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
Deletion of the beta-propeller protein gene Rv1057 reduces ESAT-6 secretion and intracellular growth of Mycobacterium tuberculosis.
The Mycobacterium tuberculosis TrcR response regulator represses transcription of the intracellularly expressed Rv1057 gene, encoding a seven-bladed beta-propeller.
The beta-propeller gene Rv1057 of Mycobacterium tuberculosis has a complex promoter directly regulated by both the MprAB and TrcRS two-component systems.
Characterization of the alanine racemases from two Mycobacteria.
The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site.
A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins.
PE_PGRS30 is required for the full virulence of Mycobacterium tuberculosis.
Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.
Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.
Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.
Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis.
Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity.
Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-beta-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis.
Characterization of DprE1-mediated benzothiazinone resistance in Mycobacterium tuberculosis.
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.
Decaprenylphosphoryl-beta-D-ribose 2'-epimerase from Mycobacterium tuberculosis is a magic drug target.
Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity.
DprE1 is a vulnerable tuberculosis drug target due to its cell wall localization.
DprE1--from the discovery to the promising tuberculosis drug target.
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhibitors.
Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies.
The 8-pyrrole-benzothiazinones are noncovalent inhibitors of DprE1 from Mycobacterium tuberculosis.
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis.
Towards a new combination therapy for tuberculosis with next generation benzothiazinones.
Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase, MenJ.
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis.
Structural and DNA binding properties of mycobacterial integration host factor mIHF.
The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages.
The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages.
Functional characterization delineates that a Mycobacterium tuberculosis specific protein kinase (Rv3080c) is responsible for the growth, phagocytosis and intracellular survival of avirulent mycobacteria.
Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation.
Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control.
The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS.
The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis.
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.
An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.
Functional plasticity and allosteric regulation of alpha-ketoglutarate decarboxylase in central mycobacterial metabolism.
Regulation of glutamate metabolism by protein kinases in mycobacteria.
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv.
Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.
Mycobacterium tuberculosis encodes a YhhN family membrane protein with lysoplasmalogenase activity that protects against toxic host lysolipids.
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
Crystal structure of the 65-kilodalton heat shock protein, chaperonin 60.2, of Mycobacterium tuberculosis.
Detection and identification of mycobacteria by PCR-RFLP method.
GroEL2 of Mycobacterium tuberculosis reveals the importance of structural pliability in chaperonin function.
Mycobacterium tuberculosis Cpn60.2 (GroEL2) blocks macrophage apoptosis via interaction with mitochondrial mortalin.
Mycobacterium tuberculosis GroEL homologues unusually exist as lower oligomers and retain the ability to suppress aggregation of substrate proteins.
Mycobacterium tuberculosis GroEL2 modulates dendritic cell responses.
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.
Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.
The dimeric structure of the Cpn60.2 chaperonin of Mycobacterium tuberculosis at 2.8 A reveals possible modes of function.
The unusual mycobacterial chaperonins: evidence for in vivo oligomerization and specialization of function.
Arginine in the FARM and SARM: a role in chain-length determination for arginine in the aspartate-rich motifs of isoprenyl diphosphate synthases from Mycobacterium tuberculosis.
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis.
Base excision and nucleotide excision repair pathways in mycobacteria.
Novel DNA glycosylases from Mycobacterium tuberculosis.
The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.
A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO.
Crystallographic and spectroscopic insights into heme degradation by Mycobacterium tuberculosis MhuD.
Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis.
Biochemical characterization of an S-adenosyl-l-methionine-dependent methyltransferase (Rv0469) of Mycobacterium tuberculosis.
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.
Dissecting the role of critical residues and substrate preference of a fatty acyl-CoA synthetase (FadD13) of Mycobacterium tuberculosis.
Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis.
Molecular basis of the functional divergence of fatty acyl-AMP ligase biosynthetic enzymes of Mycobacterium tuberculosis.
Molecular modeling studies of Fatty acyl-CoA synthetase (FadD13) from Mycobacterium tuberculosis--a potential target for the development of antitubercular drugs.
Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.
The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme.
The acid-induced operon Rv3083-Rv3089 is required for growth of Mycobacterium tuberculosis in macrophages.
mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope.
Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance.
Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis.
Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations.
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.
Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).
Mycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruent.
A bacterial transcription terminator with inefficient molecular motor action but with a robust transcription termination function.
The Mycobacterium tuberculosis purine biosynthetic pathway: isolation and characterization of the purC and purL genes.
Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP.
Mycobacterium tuberculosis type III-A CRISPR/Cas system crRNA and its maturation have atypical features.
Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3.
Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.
A green fluorescent protein-based assay for high-throughput ligand-binding studies of a mycobacterial biotin protein ligase.
Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis.
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.
Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis.
Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis.
Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration.
Targeting Mycobacterium tuberculosis biotin protein ligase (MtBPL) with nucleoside-based bisubstrate adenylation inhibitors.
Amplification and cloning of the Mycobacterium tuberculosis dnaA gene.
Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator.
Organization of the origins of replication of the chromosomes of Mycobacterium smegmatis, Mycobacterium leprae and Mycobacterium tuberculosis and isolation of a functional origin from M. smegmatis.
Formation of dTDP-rhamnose is essential for growth of mycobacteria.
Interdomain communication in the Mycobacterium tuberculosis environmental phosphatase Rv1364c.
Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c.
Role of a PAS sensor domain in the Mycobacterium tuberculosis transcription regulator Rv1364c.
Structural characterization of the multidomain regulatory protein Rv1364c from Mycobacterium tuberculosis.
Tuning the Mycobacterium tuberculosis alternative sigma factor SigF through the multidomain regulator Rv1364c and osmosensory kinase protein kinase D.
Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host.
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions.
The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling.
Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.
The crystal structure of AcrR from Mycobacterium tuberculosis reveals a one-component transcriptional regulation mechanism.
The crystal structure of AcrR from Mycobacteriumtuberculosis reveals a one-component transcriptional regulation mechanism.
Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction.
The urease locus of Mycobacterium tuberculosis and its utilization for the demonstration of allelic exchange in Mycobacterium bovis bacillus Calmette-Guerin.
Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.
Serine/threonine protein kinases PknF and PknG of Mycobacterium tuberculosis: characterization and localization.
Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo.
Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.
Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis.
IpdE1-IpdE2 is a heterotetrameric acyl coenzyme A dehydrogenase that is widely distributed in steroid-degrading bacteria.
MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis.
Novel role of Wag31 in protection of mycobacteria under oxidative stress.
Crystallization and preliminary X-ray characterization of the glpX-encoded class II fructose-1,6-bisphosphatase from Mycobacterium tuberculosis.
The Mycobacterium tuberculosis Rv1099c gene encodes a GlpX-like class II fructose 1,6-bisphosphatase.
glpX gene of Mycobacterium tuberculosis: heterologous expression, purification, and enzymatic characterization of the encoded fructose 1,6-bisphosphatase II.
glpx gene in Mycobacterium tuberculosis is required for in vitro gluconeogenic growth and in vivo survival.
Identification and architecture of a putative secretion tube across mycobacterial outer envelope.
Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies.
A cadmium-lead-sensing ArsR-SmtB repressor with novel sensory sites. Complementary metal discrimination by NmtR and CmtR in a common cytosol.
NMR structural analysis of cadmium sensing by winged helix repressor CmtR.
Structural and functional characterization of Mycobacterium tuberculosis CmtR, a PbII/CdII-sensing SmtB/ArsR metalloregulatory repressor.
Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion.
A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.
The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response.
Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.
Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase.
Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis.
Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.
Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism.
Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis.
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid.
Insights into substrate modification by dehydratases from type I polyketide synthases.
Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis.
Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis.
Matrix-assisted refolding and redox properties of WhiB3/Rv3416 of Mycobacterium tuberculosis H37Rv.
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.
Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.
Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival.
Mycobacterium tuberculosis WhiB3 responds to vacuolar pH-induced changes in mycothiol redox potential to modulate phagosomal maturation and virulence.
Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence.
Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.
Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv.
Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv.
Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis.
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
Intra- and intermolecular domain interactions among novel two-component system proteins coded by Rv0600c, Rv0601c and Rv0602c of Mycobacterium tuberculosis.
Probing the nucleotide binding and phosphorylation by the histidine kinase of a novel three-protein two-component system from Mycobacterium tuberculosis.
Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.
A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments.
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Non-acid-fastness in Mycobacterium tuberculosis DeltakasB mutant correlates with the cell envelope electron density.
Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis.
Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy.
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
Isolation of conditional expression mutants in Mycobacterium tuberculosis by transposon mutagenesis.
Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase.
Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis.
Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis.
Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis.
Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron.
The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain.
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Validation of CoaBC as a bactericidal target in the coenzyme A pathway of Mycobacterium tuberculosis.
Expression, purification, crystallization and preliminary X-ray analysis of the acyl carrier protein synthase (acpS) from Mycobacterium tuberculosis.
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.
The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria.
NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors.
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues.
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state.
Development of an unbiased antigen-mining approach to identify novel vaccine antigens and diagnostic reagents for bovine tuberculosis.
Long-range replica exchange molecular dynamics guided drug repurposing against tyrosine kinase PtkA of Mycobacterium tuberculosis.
Mycobacterial protein tyrosine kinase, PtkA phosphorylates PtpA at tyrosine residues and the mechanism is stalled by the novel series of inhibitors.
Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA.
Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis.
Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases.
Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages.
Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.
The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.
The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis, differs from the conventional kinase architecture.
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.
Indoleamides are active against drug-resistant Mycobacterium tuberculosis.
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
MmpL3 a potential new target for development of novel anti-tuberculosis drugs.
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.
A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.
Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase.
Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.
Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster.
Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties.
Redox biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide.
Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.
Putative roles of a proline-glutamic acid-rich protein (PE3) in intracellular survival and as a candidate for subunit vaccine against Mycobacterium tuberculosis.
Crystal structure of the large subunit of cobaltochelatase from Mycobacterium tuberculosis.
Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis.
Insights into the function of the WhiB-like protein of mycobacteriophage TM4--a transcriptional inhibitor of WhiB2.
WhiB2/Rv3260c, a cell division-associated protein of Mycobacterium tuberculosis H37Rv, has properties of a chaperone.
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs.
Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.
Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro.
GtrA protein Rv3789 is required for arabinosylation of arabinogalactan in Mycobacterium tuberculosis.
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.
Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability.
Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.
Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis.
In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.
Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains.
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
Cytokinin Signaling in Mycobacterium tuberculosis.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.
Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.
The C-terminal end of mycobacterial HadBC regulates AcpM interaction during the FAS-II pathway: a structural perspective.
Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase.
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis.
Structure of translation initiation factor 1 from Mycobacterium tuberculosis and inferred binding to the 30S ribosomal subunit.
A new twist of rubredoxin function in M. tuberculosis.
Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.
Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein.
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
Mycobacterial metabolic syndrome: LprG and Rv1410 regulate triacylglyceride levels, growth rate and virulence in Mycobacterium tuberculosis.
Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion.
Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.
Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds.
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis.
Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I.
Cloning, over-expression and biochemical characterization of the single-stranded DNA binding protein from Mycobacterium tuberculosis.
Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its implications.
Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis.
Structural and functional characterization of M. tuberculosis sedoheptulose-7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway.
Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis.
Elongation of the Poly-gamma-glutamate Tail of F420 Requires Both Domains of the F420:gamma-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
A variable number of tandem repeats result in polymorphic alpha-isopropylmalate synthase in Mycobacterium tuberculosis.
Mycobacterium tuberculosis strains possess functional cellulases.
Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation.
Intracellular autoregulation of the Mycobacterium tuberculosis PrrA response regulator.
The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions.
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis.
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis.
Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine.
Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.
Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis.
Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS).
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.
In vitro and in vivo characterization of a Mycobacterium tuberculosis mutant deficient in glycosyltransferase Rv1500.
PimF, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan.
A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems.
Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase Eis.
Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells.
Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion.
Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages.
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.
Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling.
Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.
Potent inhibitors of acetyltransferase Eis overcome kanamycin resistance in Mycobacterium tuberculosis.
Subcellular localization of the intracellular survival-enhancing Eis protein of Mycobacterium tuberculosis.
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.
Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.
Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.
Rv1027c-Rv1028c encode functional KdpDE two--component system in Mycobacterium tuberculosis.
Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor.
Structural views of quinone oxidoreductase from Mycobacteriumtuberculosis reveal large conformational changes induced by the co-factor.
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence.
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.
Modified genome comparison method: a new approach for identification of specific targets in molecular diagnostic tests using Mycobacterium tuberculosis complex as an example.
The crystal structure of Mycobacterium tuberculosis high-temperature requirement A protein reveals an autoregulatory mechanism.
The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features.
Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism.
Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.
Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.
Comparative study of catalase-peroxidases (KatGs).
Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis catalase-peroxidase.
Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents.
Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315.
Mycobacterium tuberculosis KatG is a peroxynitritase.
Next-generation ion torrent sequencing of drug resistance mutations in Mycobacterium tuberculosis strains.
Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis.
Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.
Redox intermediates in the catalase cycle of catalase-peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis.
Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst.
The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties.
The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.
Two [Fe(IV)=O Trp*] intermediates in M.tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid.
Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens.
Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis.
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimic acid and an ATP analogue.
Crystal structure of shikimate kinase from Mycobacterium tuberculosis reveals the dynamic role of the LID domain in catalysis.
Crystallization and preliminary X-ray diffraction analysis of shikimate kinase from Mycobacterium tuberculosis in complex with MgADP.
Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.
Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis.
Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis.
Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid.
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.
Metabolic network for the biosynthesis of intra- and extracellular alpha-glucans required for virulence of Mycobacterium tuberculosis.
Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c.
Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF-kappaB signaling and drives Th2 immune responses.
Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70.
Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.
The secreted lipoprotein, MPT83, of Mycobacterium tuberculosis is recognized during human tuberculosis and stimulates protective immunity in mice.
Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry.
Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.
DNA-dependent ATPase activity of bacterial XPB helicases.
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development.
Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library.
In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria.
Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice.
Biochemical and microbiological evaluation of N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases.
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads.
Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin.
Structural basis for lipid binding and mechanism of the Mycobacterium tuberculosis Rv3802 phospholipase.
Targeting essential cell wall lipase Rv3802c for potential therapeutics against tuberculosis.
Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability.
A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium.
Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
Rv2744c is a PspA ortholog that regulates lipid droplet homeostasis and nonreplicating persistence in Mycobacterium tuberculosis.
The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein.
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.
Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria.
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.
Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression.
Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression.
Structural and biochemical bases for the redox sensitivity of Mycobacterium tuberculosis RslA.
The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence.
Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis.
A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis.
A novel vaccine p846 encoding Rv3615c, Mtb10.4, and Rv2660c elicits robust immune response and alleviates lung injury induced by Mycobacterium infection.
ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.
Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection.
Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.
Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis.
Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site.
Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo.
Characterization of an aldolase-dehydrogenase complex from the cholesterol degradation pathway of Mycobacterium tuberculosis.
A tethering mechanism for length control in a processive carbohydrate polymerization.
Biosynthesis of the galactan component of the mycobacterial cell wall.
Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase.
Expression, purification, and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabinogalactan biosynthesis.
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
Galactosyl transferases in mycobacterial cell wall synthesis.
Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial arabinogalactan.
The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence.
Iron-dependent RNA-binding activity of Mycobacterium tuberculosis aconitase.
Characterization of an acid inducible lipase Rv3203 from Mycobacterium tuberculosis H37Rv.
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulatory domain of aspartokinase (Rv3709c) from Mycobacterium tuberculosis.
Structural view of the regulatory subunit of aspartate kinase from Mycobacterium tuberculosis.
Experimental determination of translational start sites resolves uncertainties in genomic open reading frame predictions - application to Mycobacterium tuberculosis.
Mycobacterium tuberculosis H37Rv sigC is expressed from two promoters but is not auto-regulatory.
Structural and biophysical studies on two promoter recognition domains of the extra-cytoplasmic function sigma factor sigma(C) from Mycobacterium tuberculosis.
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.
Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block.
A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor.
A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis.
Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria.
Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation.
Rv2358 and FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc.
The Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc.
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis.
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.
Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme.
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase.
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.
Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.
Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX.
Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.
NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.
Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Mycobacterial and Human Nitrobindins: Structure and Function.
Cascade of extracytoplasmic function sigma factors in Mycobacterium tuberculosis: identification of a sigmaJ-dependent promoter upstream of sigI.
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Chemical shift assignments for Rv0577, a putative glyoxylase associated with virulence from Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response.
The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10.
The PE_PGRS proteins of Mycobacterium tuberculosis are Ca(2+) binding mediators of host-pathogen interaction.
Autophagy regulation revealed by SapM-induced block of autophagosome-lysosome fusion via binding RAB7.
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis.
Secreted acid phosphatase (SapM) of Mycobacterium tuberculosis is indispensable for arresting phagosomal maturation and growth of the pathogen in guinea pig tissues.
Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases.
Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB.
Cloning and characterization of a bifunctional RelA/SpoT homologue from Mycobacterium tuberculosis.
Differential regulation of opposing RelMtb activities by the aminoacylation state of a tRNA.ribosome.mRNA.RelMtb complex.
Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis.
The stringent response of Mycobacterium tuberculosis is required for long-term survival.
Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection.
1.9 A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis.
Structural and functional characterization of the transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv.
Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.
NMR assignment and secondary structure of the STAS domain of Rv1739c, a putative sulfate transporter of Mycobacterium tuberculosis.
Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis.
SigG does not control gene expression in response to DNA damage in Mycobacterium tuberculosis H37Rv.
A TyrCD1/TrpG8 hydrogen bond network and a TyrB10TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O.
Mycobacterium tuberculosis hemoglobin HbO associates with membranes and stimulates cellular respiration of recombinant Escherichia coli.
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.
The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase.
Cyclosporin A binding to Mycobacterium tuberculosis peptidyl-prolyl cis-trans isomerase A--investigation by CD, FTIR and fluorescence spectroscopy.
X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-gamma dependant pexophagy mechanism to control redox levels in macrophages.
The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability.
Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS).
Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions.
The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis.
Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.
Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization.
Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis.
Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase.
Cloning of the lysA gene from Mycobacterium tuberculosis.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of LysA (Rv1293) from Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis.
The three-dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation.
Crystal structure of a putative aspartic proteinase domain of the Mycobacterium tuberculosis cell surface antigen PE_PGRS16.
Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division.
Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain.
Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis.
Small-molecule probes reveal esterases with persistent activity in dormant and reactivating Mycobacterium tuberculosis.
Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway.
Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.
RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.
rmlB and rmlC genes are essential for growth of mycobacteria.
A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem.
A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.
Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motif.
Blockage of the channel to heme by the E87 side chain in the GAF domain of Mycobacterium tuberculosis DosS confers the unique sensitivity of DosS to oxygen.
Crystal structures of the CO- and NO-bound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis.
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy.
DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.
Distal hydrogen-bonding interactions in ligand sensing and signaling by Mycobacterium tuberculosis DosS.
DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis.
Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor.
Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis.
Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT.
The DosS-DosT/DosR mycobacterial sensor system.
Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis.
Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy.
FadD3 is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria.
Biochemical characterization of recombinant phosphoglucose isomerase of Mycobacterium tuberculosis.
Crystallization and preliminary X-ray characterization of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv.
Functional phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv: rapid purification with high yield and purity.
Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv.
An unusual, His-dependent family I pyrophosphatase from Mycobacterium tuberculosis.
Analysis of stress- and host cell-induced expression of the Mycobacterium tuberculosis inorganic pyrophosphatase.
Mycobacterium tuberculosis Rv3628 drives Th1-type T cell immunity via TLR2-mediated activation of dendritic cells and displays vaccine potential against the hyper-virulent Beijing K strain.
Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
Structure of the Mycobacterium tuberculosis soluble inorganic pyrophosphatase Rv3628 at pH 7.0.
Identification of microbial dimethylarginine dimethylaminohydrolase enzymes.
HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria.
HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis.
Identification of [2Fe-2S] clusters in microbial ferrochelatases.
Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin.
Prokaryotic heme biosynthesis: multiple pathways to a common essential product.
Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.
Molecular basis for DarT ADP-ribosylation of a DNA base.
The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.
Overexpression, purification, crystallization and preliminary X-ray analysis of putative molybdenum cofactor biosynthesis protein C (MoaC2) from Mycobacterium tuberculosis H37Rv.
Comparative proteome analysis of culture supernatant proteins of Mycobacterium tuberculosis H37Rv and H37Ra.
Substrate specificities and functional characterization of a thermo-tolerant uracil DNA glycosylase (UdgB) from Mycobacterium tuberculosis.
RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: insights into negative regulation of homologous recombination.
Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.
A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.
Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.
Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.
A novel function of Mycobacterium tuberculosis chaperonin paralog GroEL1 in copper homeostasis.
Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization.
Interplays between copper and Mycobacterium tuberculosis GroEL1.
Mycobacterium tuberculosis expresses two chaperonin-60 homologs.
Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 is a chaperonin.
The Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases.
Towards understanding the biological function of the unusual chaperonin Cpn60.1 (GroEL1) of Mycobacterium tuberculosis.
Characterization and function of Mycobacterium tuberculosis H37Rv Lipase Rv1076 (LipU).
Characterization of an extracellular protein, Rv1076 from M. tuberculosis with a potential role in humoral response.
Drug targeted virtual screening and molecular dynamics of LipU protein of Mycobacterium tuberculosis and Mycobacterium leprae.
Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.
Advance in research on Mycobacterium tuberculosis FabG4 and its inhibitor.
Crystal structure of FabG4 from Mycobacterium tuberculosis reveals the importance of C-terminal residues in ketoreductase activity.
Crystal structure of hexanoyl-CoA bound to beta-ketoacyl reductase FabG4 of Mycobacterium tuberculosis.
Crystallization and preliminary X-ray diffraction analysis of the high molecular weight ketoacyl reductase FabG4 complexed with NADH.
Design, synthesis and characterization of novel inhibitors against mycobacterial beta-ketoacyl CoA reductase FabG4.
Inhibition of M. tuberculosis beta-ketoacyl CoA reductase FabG4 (Rv0242c) by triazole linked polyphenol-aminobenzene hybrids: comparison with the corresponding gallate counterparts.
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.
Development of a novel lead that targets M.tuberculosis polyketide synthase 13.
Identification of novel coumestan derivatives as polyketide synthase 13 inhibitors against Mycobacterium tuberculosis.
Identification of novel coumestan derivatives as polyketide synthase 13 inhibitors against Mycobacterium tuberculosis. Part II.
The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.
The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis.
The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria.
Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier.
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice.
Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase from Mycobacterium tuberculosis.
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria.
Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli.
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
'Depupylation' of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates.
Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis.
Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations.
Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.
Biochemical and functional characterization of triosephosphate isomerase from Mycobacterium tuberculosis H37Rv.
Structural and functional characterization of Mycobacterium tuberculosis triosephosphate isomerase.
Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.
FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.
Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.
Molecular cloning of the leuB genes from Mycobacterium bovis BCG and Mycobacterium tuberculosis.
The high-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis.
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain.
Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme.
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid.
A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10).
CFP-10 from Mycobacterium tuberculosis selectively activates human neutrophils through a pertussis toxin-sensitive chemotactic receptor.
CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interaction.
Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence.
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity.
ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells.
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity.
Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis.
Potential role for ESAT6 in dissemination of M. tuberculosis via human lung epithelial cells.
Region of difference 1 in nontuberculous Mycobacterium species adds a phylogenetic and taxonomical character.
Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6.
The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (beta2M) affecting antigen presentation function of macrophage.
Two distinct conformational states of Mycobacterium tuberculosis virulent factor early secreted antigenic target 6 kDa are behind the discrepancy around its biological functions.
WXG100 protein superfamily consists of three subfamilies and exhibits an alpha-helical C-terminal conserved residue pattern.
A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis.
Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases.
Eukaryotic-like adenylyl cyclases in Mycobacterium tuberculosis H37Rv: cloning and characterization.
New structural forms of a mycobacterial adenylyl cyclase Rv1625c.
Genomic organization of the mycobacterial sigma gene cluster.
The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.
Transcription of two sigma 70 homologue genes, sigA and sigB, in stationary-phase Mycobacterium tuberculosis.
Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis.
A native ternary complex trapped in a crystal reveals the catalytic mechanism of a retaining glycosyltransferase.
Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis.
Structural snapshots and loop dynamics along the catalytic cycle of glycosyltransferase GpgS.
The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.
The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c.
Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions.
The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
Cloning, expression, and characterization of polyphosphate glucokinase from Mycobacterium tuberculosis.
Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis.
Rv3303c of Mycobacterium tuberculosis protects tubercle bacilli against oxidative stress in vivo and contributes to virulence in mice.
VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA.
An essential two-component signal transduction system in Mycobacterium tuberculosis.
Elements of signal transduction in Mycobacterium tuberculosis: in vitro phosphorylation and in vivo expression of the response regulator MtrA.
Mycobacterium tuberculosis mtrA merodiploid strains with point mutations in the signal-receiving domain of MtrA exhibit growth defects in nutrient broth.
Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression.
Lipoproteins of slow-growing Mycobacteria carry three fatty acids and are N-acylated by apolipoprotein N-acyltransferase BCG_2070c.
A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli.
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.
Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis.
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.
CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.
Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.
Cloning and sequencing of a unique antigen MPT70 from Mycobacterium tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle vector.
Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis.
WhiB5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation.
EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/threonine kinases and phosphatase in Mycobacterium tuberculosis.
Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.
Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.
PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity.
Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.
Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria.
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.
Crystallization of a protein using dehydration without a precipitant.
Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence.
Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins.
Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice.
The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis.
Crystal structures of manganese-dependent transcriptional repressor MntR (Rv2788) from Mycobacterium tuberculosis in apo and manganese bound forms.
Insight into isoprenoid biosynthesis by functional analysis of isoprenyl diphosphate synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis.
Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics.
Characterization of a bifunctional beta-lactamase/ribonuclease and its interaction with a chaperone-like protein in the pathogen Mycobacterium tuberculosis H37Rv.
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket.
Heme and hemoglobin utilization by Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
Expression, autoregulation, and DNA binding properties of the Mycobacterium tuberculosis TrcR response regulator.
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
The evolution of SMC proteins: phylogenetic analysis and structural implications.
A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria.
Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.
Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.
Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.
The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance.
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system.
ChiZ levels modulate cell division process in mycobacteria.
Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase.
The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.
LipC (Rv0220) is an immunogenic cell surface esterase of Mycobacterium tuberculosis.
Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.
Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes.
Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation.
Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.
Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency.
The residue threonine 82 of DevR (DosR) is essential for DevR activation and function in Mycobacterium tuberculosis despite its atypical location.
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.
Recombinant Rv3261 protein of Mycobacterium tuberculosis induces apoptosis through a mitochondrion-dependent pathway in macrophages and inhibits intracellular bacterial growth.
Structural characterization of glycinamide-RNase-transformylase T from Mycobacterium tuberculosis.
B cells response directed against Cut4 and CFP21 lipolytic enzymes in active and latent tuberculosis infections.
Purification and characterization of mycobacterial phospholipase A: an activity associated with mycobacterial cutinase.
Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function.
Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis.
Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis.
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.
Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.
Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
Structural and biochemical analyses of Mycobacterium tuberculosis N-acetylmuramyl-L-alanine amidase Rv3717 point to a role in peptidoglycan fragment recycling.
The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis.
Rv1288, a two domain, cell wall anchored, nutrient stress inducible carboxyl-esterase of Mycobacterium tuberculosis, modulates cell wall lipid.
Rv3272 encodes a novel family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress.
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding Site.
Overexpression, purification and biochemical characterization of a class A high-molecular-mass penicillin-binding protein (PBP), PBP1* and its soluble derivative from Mycobacterium tuberculosis.
Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis.
Mycobacterium tuberculosis thioredoxin reductase is essential for thiol redox homeostasis but plays a minor role in antioxidant defense.
A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase.
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA.
Mycobacterium tuberculosis FprA, a novel bacterial NADPH-ferredoxin reductase.
Role of the His57-Glu214 ionic couple located in the active site of Mycobacterium tuberculosis FprA.
Identification of a cadmium-induced gene in Mycobacterium bovis and Mycobacterium tuberculosis.
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.
Expression, purification and characterisation of secreted esterase Rv2525c from Mycobacterium tuberculosis.
Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria.
The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.
The hydrolase LpqI primes mycobacterial peptidoglycan recycling.
Characterization of M. tuberculosis SerB2, an essential HAD-family phosphatase, reveals novel properties.
The M. tuberculosis HAD phosphatase (Rv3042c) interacts with host proteins and is inhibited by Clofazimine.
Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.
Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism.
Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis.
Characterization of FtsY, its interaction with Ffh, and proteomic identification of their potential substrates in Mycobacterium tuberculosis.
Essential biochemical, biophysical and computational inputs on efficient functioning of Mycobacterium tuberculosis H37Rv FtsY.
Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis. A novel carboxyl esterase structurally related to the HSL family.
Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 A resolution - a potential target for anti-tuberculosis drug discovery.
Expression and purification of the Mycobacterium tuberculosis complex-restricted antigen CFP21 to study its immunoprophylactic potential in mouse model.
Identification of residues involved in substrate specificity and cytotoxicity of two closely related cutinases from Mycobacterium tuberculosis.
Crystal structures identify an atypical two-metal-ion mechanism for uridyltransfer in GlmU: its significance to sugar nucleotidyl transferases.
Structure and function of GlmU from Mycobacterium tuberculosis.
Structure of N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) from Mycobacterium tuberculosis in a cubic space group.
Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv.
The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.
A phagosomally expressed gene, rv0428c, of Mycobacterium tuberculosis demonstrates acetyl transferase activity and plays a protective role under stress conditions.
Phosphatidylinositol is an essential phospholipid of mycobacteria.
In-house UV radiation-damage-induced phasing of selenomethionine-labeled protein structures.
Structure of chorismate synthase from Mycobacterium tuberculosis.
Mycobacterium tuberculosis PE9 protein has high activity binding peptides which inhibit target cell invasion.
The Mycobacterium tuberculosis protein pair PE9 (Rv1088)-PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through Toll-like receptor 4.
Trehalose synthase converts glycogen to trehalose.
Cloning, expression, purification, crystallization and X-ray crystallographic analysis of Rv3168 from Mycobacterium tuberculosis H37Rv.
Crystal structure of Mycobacterium tuberculosis Rv3168: a putative aminoglycoside antibiotics resistance enzyme.
Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex.
The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities.
Expression and characterization of the carboxyl esterase Rv3487c from Mycobacterium tuberculosis.
Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis.
Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis.
Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation.
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis.
The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt(1) by carbapenems and cephalosporins.
Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation.
Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.
Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1beta immune pathway.
Mycobacterium tuberculosis PPE protein Rv0256c induces strong B cell response in tuberculosis patients.
Mycobacterium tuberculosis PPE2 protein interacts with p67phox and inhibits reactive oxygen species production.
Mycobacterium tuberculosis: what is the role of PPE2 during infection?
PPE2 protein of Mycobacterium tuberculosis may inhibit nitric oxide in activated macrophages.
The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production.
Structure of mycobacterial beta-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathway.
Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme.
Cloning, expression, purification and characterization of DNA topoisomerase I of Mycobacterium tuberculosis.
Identification of a novel carboxypeptidase encoded by Rv3627c that plays a potential role in mycobacteria morphology and cell division.
A PCR method for the sequence analysis of the gyrA, polA and rnhA gene segments from mycobacteria.
Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL.
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability.
Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein.
Mapping conformational transitions in cyclic AMP receptor protein: crystal structure and normal-mode analysis of Mycobacterium tuberculosis apo-cAMP receptor protein.
Profound asymmetry in the structure of the cAMP-free cAMP receptor protein (CRP) from Mycobacterium tuberculosis.
Solution NMR evidence for symmetry in functionally or crystallographically asymmetric homodimers.
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein.
A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.
FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis.
Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis.
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.
Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice.
Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates.
Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis.
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP.
cAMP-regulated protein lysine acetylases in mycobacteria.
Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis.
RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria.
A cooperative oxygen binding hemoglobin from Mycobacterium tuberculosis. Stabilization of heme ligands by a distal tyrosine residue.
Cyanide binding to truncated hemoglobins: a crystallographic and kinetic study.
Heme-ligand tunneling in group I truncated hemoglobins.
Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues.
Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme.
Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon.
Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: requirement for establishing chronic persistent infection.
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Rv0802c acetyltransferase from Mycobacterium tuberculosis H37Rv.
Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold.
Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.
Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments.
Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases.
Structural and biochemical characterization of the essential DsbA-like disulfide bond forming protein from Mycobacterium tuberculosis.
Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c.
Cloning, expression, purification, crystallization and preliminary crystallographic analysis of Rv1698, an outer membrane channel protein from Mycobacterium tuberculosis.
Copper resistance is essential for virulence of Mycobacterium tuberculosis.
Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins.
A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis.
Purified recombinant hypothetical protein coded by open reading frame Rv1885c of Mycobacterium tuberculosis exhibits a monofunctional AroQ class of periplasmic chorismate mutase activity.
Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cells.
The multifunctional PE_PGRS11 protein from Mycobacterium tuberculosis plays a role in regulating resistance to oxidative stress.
The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.
Monoclonal antibodies specific for elongation factor Tu and complete nucleotide sequence of the tuf gene in Mycobacterium tuberculosis.
Three pathways for trehalose biosynthesis in mycobacteria.
A distinct physiological role of MutY in mutation prevention in mycobacteria.
A distinct role of formamidopyrimidine DNA glycosylase (MutM) in down-regulation of accumulation of G, C mutations and protection against oxidative stress in mycobacteria.
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization.
Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.
Purine Salvage Pathway in Mycobacterium tuberculosis.
Purine metabolism in Mycobacterium tuberculosis as a target for drug development.
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.
Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides.
Identification of operator sites within the upstream region of the putative mce2R gene from mycobacteria.
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.
Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice.
Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family.
Mycobacterium tuberculosis PE_PGRS18 enhances the intracellular survival of M. smegmatis via altering host macrophage cytokine profiling and attenuating the cell apoptosis.
Rv1717 is a cell wall-associated beta-galactosidase of Mycobacterium tuberculosis that is involved in biofilm dispersion.
Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
Identification of apolipoprotein N-acyltransferase (Lnt) in mycobacteria.
In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system.
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.
EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis.
Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis.
Crystal structure of DNA polymerase III beta sliding clamp from Mycobacterium tuberculosis.
M. tuberculosis sliding beta-clamp does not interact directly with the NAD+-dependent DNA ligase.
Targeting DnaN for tuberculosis therapy using novel griselimycins.
Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution.
Structure of a Mycobacterium tuberculosis NusA-RNA complex.
Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis.
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.
Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv.
Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome.
Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives.
MMAS-1, the branch point between cis- and trans-cyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis.
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.
Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis.
A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis.
A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.
Crucial components of Mycobacterium type II fatty acid biosynthesis (Fas-II) and their inhibitors.
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis.
Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
Direct inhibitors of InhA are active against Mycobacterium tuberculosis.
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.
Mechanism of thioamide drug action against tuberculosis and leprosy.
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
N-Benzyl-4-((heteroaryl)methyl)benzamides: a new class of direct NADH-dependent 2-trans enoyl-acyl carrier protein reductase (InhA) inhibitors with antitubercular activity.
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.
Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival.
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.
Rational modulation of the induced-fit conformational change for slow-onset inhibition in Mycobacterium tuberculosis InhA.
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.
Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.
Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data.
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.
Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy.
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
Cloning, expression, purification and preliminary crystallographic analysis of the RNase HI domain of the Mycobacterium tuberculosis protein Rv2228c as a maltose-binding protein fusion.
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis.
Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis.
Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.
Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.
The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis.
A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.
Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis.
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue.
S-nitroso proteome of Mycobacterium tuberculosis: enzymes of intermediary metabolism and antioxidant defense.
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa.
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.
Discovery and characterization of HemQ: an essential heme biosynthetic pathway component.
Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG.
Cloning, sequence determination, and expression of a 32-kilodalton-protein gene of Mycobacterium tuberculosis.
Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis.
Evidence for three separate genes encoding the proteins of the mycobacterial antigen 85 complex.
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.
Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis.
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
Single nucleotide polymorphisms in cell wall biosynthesis-associated genes and phylogeny of Mycobacterium tuberculosis lineages.
The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation.
Rhomboid homologs in Mycobacteria: insights from phylogeny and genomic analysis.
Co-induction of methyltransferase Rv0560c by naphthoquinones and fibric acids suggests attenuation of isoprenoid quinone action in Mycobacterium tuberculosis.
Gene expression profiling analysis of Mycobacterium tuberculosis genes in response to salicylate.
Modification of the Pseudomonas aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria.
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.
The inhibitory effect of GlmU acetyltransferase inhibitor TPSA on Mycobacterium tuberculosis may be affected due to its methylation by methyltransferase Rv0560c.
Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis.
Characterization of novel acyl coenzyme A dehydrogenases involved in bacterial steroid degradation.
4'-phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo.
Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
Insights from the docking and molecular dynamics simulation of the Phosphopantetheinyl transferase (PptT) structural model from Mycobacterium tuberculosis.
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria.
Functional characterization of a novel ArgA from Mycobacterium tuberculosis.
Structural basis for phosphatidylinositol-phosphate biosynthesis.
Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis.
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system.
Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis.
X-ray structure of putative acyl-ACP desaturase DesA2 from Mycobacterium tuberculosis H37Rv.
Increased levels of sigJ mRNA in late stationary phase cultures of Mycobacterium tuberculosis detected by DNA array hybridisation.
The Mycobacterium tuberculosis sigJ gene controls sensitivity of the bacterium to hydrogen peroxide.
Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis.
Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.
Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation.
First functional characterization of a singly expressed bacterial type II topoisomerase: the enzyme from Mycobacterium tuberculosis.
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency.
Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion.
Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.
Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.
The role of Ca(2+) in the activity of Mycobacterium tuberculosis DNA gyrase.
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase.
Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide.
The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids.
Sequence of a newly identified Mycobacterium tuberculosis gene encoding a protein with sequence homology to virulence-regulating proteins.
Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
The product complex of M. tuberculosis malate synthase revisited.
Export-mediated assembly of mycobacterial glycoproteins parallels eukaryotic pathways.
MTC28, a novel 28-kilodalton proline-rich secreted antigen specific for the Mycobacterium tuberculosis complex.
Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase.
Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase.
Molecular function of WhiB4/Rv3681c of Mycobacterium tuberculosis H37Rv: a [4Fe-4S] cluster co-ordinating protein disulphide reductase.
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection.
Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin.
The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination.
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.
Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
Identifying putative Mycobacterium tuberculosis Rv2004c protein sequences that bind specifically to U937 macrophages and A549 epithelial cells.
Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs.
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli.
Analysis of genetic polymorphism in the phospholipase region of Mycobacterium tuberculosis.
Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria.
Evidence for the expression of native Mycobacterium tuberculosis phospholipase C: recognition by immune sera and detection of promoter activity.
Isolation, characterization, and molecular cloning of a specific Mycobacterium tuberculosis antigen gene: identification of a species-specific sequence.
Tuberculosis: new strategies for the development of diagnostic tests and vaccines.
Ancestral antibiotic resistance in Mycobacterium tuberculosis.
The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance.
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis.
Finding of the low molecular weight inhibitors of resuscitation promoting factor enzymatic and resuscitation activity.
Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines.
Proteins of the Rpf family: immune cell reactivity and vaccination efficacy against tuberculosis in mice.
Resuscitation factors from mycobacteria: homologs of Micrococcus luteus proteins.
The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of bacterioferritin A from Mycobacterium tuberculosis.
Crystal structure of Bfr A from Mycobacterium tuberculosis: incorporation of selenomethionine results in cleavage and demetallation of haem.
Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection.
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis.
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.
Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.
Backbone structure of a small helical integral membrane protein: A unique structural characterization.
Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapB (Rv2773c) from Mycobacterium tuberculosis.
The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms.
The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity.
Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis.
The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design.
The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics.
Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids.
The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M. tuberculosis.
Mycobacterium tuberculosis possesses an unusual tmRNA rescue system.
Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.
Directed evolution of Mycobacterium tuberculosis beta-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.
Fluorogenic probes with substitutions at the 2 and 7 positions of cephalosporin are highly BlaC-specific for rapid Mycobacterium tuberculosis detection.
Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics.
Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate.
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.
NXL104 irreversibly inhibits the beta-lactamase from Mycobacterium tuberculosis.
Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe.
Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.
Structures of the Michaelis complex (1.2 A) and the covalent acyl intermediate (2.0 A) of cefamandole bound in the active sites of the Mycobacterium tuberculosis beta-lactamase K73A and E166A mutants.
The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases.
Characterization of LipN (Rv2970c) of Mycobacterium tuberculosis H37Rv and its probable role in xenobiotic degradation.
Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis.
Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.
Cholesterol ester oxidation by mycobacterial cytochrome P450.
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry.
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis.
Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.
Identification of the Mycobacterium tuberculosis protein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression.
Mycobacterium tuberculosis cell wall-associated Rv3812 protein induces strong dendritic cell-mediated interferon gamma responses and exhibits vaccine potential.
PE_PGRS62 promotes the survival of Mycobacterium smegmatis within macrophages via disrupting ER stress-mediated apoptosis.
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.
Mycobacterium tuberculosis IMPDH in complexes with substrates, products and antitubercular compounds.
Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis.
Mycobacterium tuberculosis region of difference (RD) 2 antigen Rv1985c and RD11 antigen Rv3425 have the promising potential to distinguish patients with active tuberculosis from M. bovis BCG-vaccinated individuals.
Novel recombinant RD2- and RD11-encoded Mycobacterium tuberculosis antigens are potential candidates for diagnosis of tuberculosis infections in BCG-vaccinated individuals.
PPE protein (Rv3425) from DNA segment RD11 of Mycobacterium tuberculosis: a novel immunodominant antigen of Mycobacterium tuberculosis induces humoral and cellular immune responses in mice.
PPE protein (Rv3425) from DNA segment RD11 of Mycobacterium tuberculosis: a potential B-cell antigen used for serological diagnosis to distinguish vaccinated controls from tuberculosis patients.
PPE57 induces activation of macrophages and drives Th1-type immune responses through TLR2.
Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.
Post-translational Succinylation of Mycobacterium tuberculosis Enoyl-CoA Hydratase EchA19 Slows Catalytic Hydration of Cholesterol Catabolite 3-Oxo-chol-4,22-diene-24-oyl-CoA.
Succinylome analysis reveals the involvement of lysine succinylation in metabolism in pathogenic Mycobacterium tuberculosis.
Purification and molecular characterization of a novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.
Structural insights into the novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.
The perilipin-like PPE15 protein in Mycobacterium tuberculosis is required for triacylglycerol accumulation under dormancy-inducing conditions.
A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug.
Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Roles of trpE2, entC and entD in salicylic acid biosynthesis in Mycobacterium smegmatis.
Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis.
The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase.
AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain.
Expression, purification and preliminary crystallographic analysis of Rv2247, the beta subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.
Structure, activity, and inhibition of the carboxyltransferase beta-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III.
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.
Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
Characterization of the helicase activity and substrate specificity of Mycobacterium tuberculosis UvrD.
Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair.
Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins.
Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway.
Atypical OmpR/PhoB subfamily response regulator GlnR of actinomycetes functions as a homodimer, stabilized by the unphosphorylated conserved Asp-focused charge interactions.
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis.
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
Structure of the inactive variant C60S of Mycobacterium tuberculosis thiol peroxidase.
Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene.
Characterization of the Mycobacterium tuberculosis erp gene encoding a potential cell surface protein with repetitive structures.
Identification of Mycobacterium tuberculosis DNA sequences encoding exported proteins by using phoA gene fusions.