Genome sequence of the nematode C. elegans: a platform for investigating biology.
A new DNA-binding motif in the Skn-1 binding domain-DNA complex.
Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2.
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans.
Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.
Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.
Investigating the role of RIO protein kinases in Caenorhabditis elegans.
Mitochondrial SKN-1/Nrf mediates a conserved starvation response.
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans.
TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.
The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration.
Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo.
CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.
Neddylation and deneddylation of CUL-3 is required to target MEI-1/katanin for degradation at the meiosis-to-mitosis transition in C. elegans.
VHA-19 is essential in Caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytes.
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Caenorhabditis elegans has scores of homoeobox-containing genes.
Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression.
Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans.
Expression of the unc-4 homeoprotein in Caenorhabditis elegans motor neurons specifies presynaptic input.
Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/groucho in Caenorhabditis elegans cholinergic motor neurons.
Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans.
The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans.
UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit.
UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans.
UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans.
EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans.
Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans.
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor.
The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor.
The roles of an ephrin and a semaphorin in patterning cell-cell contacts in C. elegans sensory organ development.
A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.
A histone methylation network regulates transgenerational epigenetic memory in C. elegans.
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.
Functional characterization of SR and SR-related genes in Caenorhabditis elegans.
SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development.
An SMC-like protein binds and regulates Caenorhabditis elegans condensins.
Caenorhabditis elegans compensates for the difference in X chromosome dosage between the sexes by regulating transcript levels.
Condensin and the spindle midzone prevent cytokinesis failure induced by chromatin bridges in C. elegans embryos.
Condensin restructures chromosomes in preparation for meiotic divisions.
Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure.
Meiotic crossover number and distribution are regulated by a dosage compensation protein that resembles a condensin subunit.
SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes.
Three distinct condensin complexes control C. elegans chromosome dynamics.
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
Evidence that Caenorhabditis elegans 32-kDa beta-galactoside-binding protein is homologous to vertebrate beta-galactoside-binding lectins. cDNA cloning and deduced amino acid sequence.
Purification and characterization of beta-galactoside-binding proteins from Caenorhabditis elegans.
Structure of the 32-kDa galectin gene of the nematode Caenorhabditis elegans.
Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans.
Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.
Functional specialization of sensory cilia by an RFX transcription factor isoform.
RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.
The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans.
A monoclonal antibody toolkit for C. elegans.
DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.
Genetic control of nucleolar size: An evolutionary perspective.
Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.
Nucleologenesis in the Caenorhabditis elegans embryo.
Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans.
The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein.
Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division.
Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.
Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.
The glycosylceramides of the nematode Caenorhabditis elegans contain an unusual, branched-chain sphingoid base.
Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis.
Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance.
Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development.
C. elegans screen identifies autophagy genes specific to multicellular organisms.
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans.
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2.
PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.
The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.
The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans.
The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation.
The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway.
epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans.
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans.
A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans.
Distinct beta-catenins mediate adhesion and signalling functions in C. elegans.
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
Identification of evolutionarily conserved promoter elements and amino acids required for function of the C. elegans beta-catenin homolog BAR-1.
LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans.
Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development.
The axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development.
The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.
The transcription factor HLH-26 controls probiotic-mediated protection against intestinal infection through up-regulation of the Wnt/BAR-1 pathway.
Two functionally distinct axin-like proteins regulate canonical Wnt signaling in C. elegans.
Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.
The astacin protein family in Caenorhabditis elegans.
Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.
Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.
The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo.
kin-18, a C. elegans protein kinase involved in feeding.
C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells.
CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.
Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).
Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.
Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.
Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.
Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.
Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.
Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.
Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.
Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior.
CFP-1 interacts with HDAC1/2 complexes in C. elegans development.
Extreme HOT regions are CpG-dense promoters in C. elegans and humans.
Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.
NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling.
The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes.
C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation.
Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans.
Regulation of C. elegans neuronal differentiation by the ZEB-family factor ZAG-1 and the NK-2 homeodomain factor CEH-28.
zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans.
Germline and developmental roles of the nuclear transport factor importin alpha3 in C. elegans.
Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function.
The homeoproteins MAB-18 and CEH-14 insulate the dauer collagen gene col-43 from activation by the adjacent promoter of the Spermatheca gene sth-1 in Caenorhabditis elegans.
The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology.
The EARP complex and its interactor eipr-1 are required for cargo sorting to dense-core vesicles.
PPM-1, a PP2Calpha/beta phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans.
Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation.
Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2.
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.
Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.
SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans.
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis.
Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.
A Caenorhabditis elegans wee1 homolog is expressed in a temporally and spatially restricted pattern during embryonic development.
An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans.
Functional characterization of five eIF4E isoforms in Caenorhabditis elegans.
Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues.
Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation.
Multiple isoforms of eukaryotic protein synthesis initiation factor 4E in Caenorhabditis elegans can distinguish between mono- and trimethylated mRNA cap structures.
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability.
Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease.
UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells.
Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans.
Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49.
Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.
The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans.
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay.
A novel zinc-carboxypeptidase SURO-1 regulates cuticle formation and body morphogenesis in Caenorhabditis elegans.
Caenorhabditis elegans MAI-1 protein, which is similar to mitochondrial ATPase inhibitor (IF1), can inhibit yeast F0F1-ATPase but cannot be transported to yeast mitochondria.
Mg2+ extrusion from intestinal epithelia by CNNM proteins is essential for gonadogenesis via AMPK-TORC1 signaling in Caenorhabditis elegans.
Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons.
Genes affecting sensitivity to serotonin in Caenorhabditis elegans.
Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.
The genetics of feeding in Caenorhabditis elegans.
The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.
Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans.
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.
Molecular cloning and characterization of dullard: a novel gene required for neural development.
Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway.
Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.
Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects.
Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans.
The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.
CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans.
MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation.
Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans.
Spatiotemporal control of a novel synaptic organizer molecule.
Transcriptional control of synaptic remodeling through regulated expression of an immunoglobulin superfamily protein.
Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans.
The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans.
smg-7 is required for mRNA surveillance in Caenorhabditis elegans.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.
Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
Crystal structure of the worm NitFhit Rosetta stone protein reveals a Nit tetramer binding two Fhit dimers.
Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.
Chromosome cohesion is regulated by a clock gene paralogue TIM-1.
Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21.
Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.
A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans.
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth.
PH domain of ELMO functions in trans to regulate Rac activation via Dock180.
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.
The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.
The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.
The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state.
C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans.
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
The structure of the human multiple exostoses 2 gene and characterization of homologs in mouse and Caenorhabditis elegans.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.
Identification and characterization of a novel allele of Caenorhabditis elegans bbs-7.
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors.
Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
The BBSome controls IFT assembly and turnaround in cilia.
Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide.
Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans.
Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry.
Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.
FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1.
FMRFamide-related gene family in the nematode, Caenorhabditis elegans.
Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans.
Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor.
C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins.
Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.
Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.
The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis.
Germline X chromosomes exhibit contrasting patterns of histone H3 methylation in Caenorhabditis elegans.
Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans.
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.
Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements.
Role of Caenorhabditis elegans protein phosphatase type 1, CeGLC-7 beta, in metaphase to anaphase transition during embryonic development.
The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription.
The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans.
The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis.
The primary structure of histone H3 from the nematode Caenorhabditis elegans.
X-chromosome silencing in the germline of C. elegans.
Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development.
Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program.
Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans.
Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior.
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
Distantly related plant and nematode core alpha1,3-fucosyltransferases display similar trends in structure-function relationships.
Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.
Molecular cloning and characterization of an alpha1,3 fucosyltransferase, CEFT-1, from Caenorhabditis elegans.
Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.
Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri generates a short transcript that provides tissue-specific function in BMP signaling.
An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGFbeta signaling during mesodermal patterning.
Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGFbeta signaling.
SMAD Transcription Factor, Sma-9, Attunes TGF-beta Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans.
The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling.
The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm.
Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs.
A genome-wide survey and systematic RNAi-based characterization of helicase-like genes in Caenorhabditis elegans.
Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans.
Evolutionary plasticity in the innate immune function of Akirin.
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.
The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination.
The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.
DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans.
Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos.
Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development.
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.
The conserved kinases CDK-1, GSK-3, KIN-19, and MBK-2 promote OMA-1 destruction to regulate the oocyte-to-embryo transition in C. elegans.
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell.
Functional coordination of WAVE and WASP in C. elegans neuroblast migration.
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
Genetic analysis of crawling and swimming locomotory patterns in C. elegans.
Genetic analysis of halothane sensitivity in Caenorhabditis elegans.
Multiple sites of action of volatile anesthetics in Caenorhabditis elegans.
The effect of two genes on anesthetic response in the nematode Caenorhabditis elegans.
UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades.
Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3.
Functional genomic analysis of apoptotic DNA degradation in C. elegans.
Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes.
Molecular and biochemical characterization of nematode cofactor independent phosphoglycerate mutases.
DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos.
Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.
Molecular cloning and characterization of the dpy-20 gene of Caenorhabditis elegans.
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless.
Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans.
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position.
Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans.
Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.
Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.
Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.
The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency.
Sequence comparison of the Caenorhabditis elegans dpy-13 and col-34 genes, and their deduced collagen products.
dpy-13: a nematode collagen gene that affects body shape.
Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths.
Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans.
Contribution of the peroxisomal acox gene to the dynamic balance of daumone production in Caenorhabditis elegans.
The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter.
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.
Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.
Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development.
C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.
Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.
The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling.
Clustered LAG-1 binding sites in lag-1/CSL are involved in regulating lag-1 expression during lin-12/Notch-dependent cell-fate specification.
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.
GLP-1 Notch-LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1.
LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway.
Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons.
Positive autoregulation of lag-1 in response to LIN-12 activation in cell fate decisions during C. elegans reproductive system development.
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.
Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor.
The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans.
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).
Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development.
Promoters recognized by forkhead proteins exist for individual 21U-RNAs.
The forkhead gene family of Caenorhabditis elegans.
The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.
VHA-8, the E subunit of V-ATPase, is essential for pH homeostasis and larval development in C. elegans.
Vacuolar-type H+-ATPase E subunit is required for embryogenesis and yolk transfer in Caenorhabditis elegans.
Molecular characterization in the dpy-14 region identifies the adenosylhomocysteine hydrolase gene in Caenorhabditis elegans.
Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration.
RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains.
The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors.
Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon.
Mutations that disrupt the morphogenesis and localization of a sperm-specific organelle in Caenorhabditis elegans.
The spe-10 mutant has longer life and increased stress resistance.
spe-10 encodes a DHHC-CRD zinc-finger membrane protein required for endoplasmic reticulum/Golgi membrane morphogenesis during Caenorhabditis elegans spermatogenesis.
C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.
A molecular link between gene-specific and chromosome-wide transcriptional repression.
DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode.
Independent domains of the Sdc-3 protein control sex determination and dosage compensation in C. elegans.
MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation.
Recruitment of C. elegans dosage compensation proteins for gene-specific versus chromosome-wide repression.
SDC-3 coordinates the assembly of a dosage compensation complex on the nematode X chromosome.
Sex-specific assembly of a dosage compensation complex on the nematode X chromosome.
ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.
A palmitoyl-CoA-specific delta9 fatty acid desaturase from Caenorhabditis elegans.
Genetic regulation of unsaturated fatty acid composition in C. elegans.
Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD.
CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.
ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans.
TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
Functional identification of a fatty acid delta5 desaturase gene from Caenorhabditis elegans.
Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans.
Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans.
The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.
Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis.
EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans.
Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo.
Sequential histone-modifying activities determine the robustness of transdifferentiation.
The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning.
The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans.
DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.
NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans.
RbAp46/48(LIN-53) is required for holocentromere assembly in Caenorhabditis elegans.
Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.
Katanin spiral and ring structures shed light on power stroke for microtubule severing.
Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component.
MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis.
MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.
Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation.
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
The C. elegans DYRK Kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation.
The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo.
mei-1, a gene required for meiotic spindle formation in Caenorhabditis elegans, is a member of a family of ATPases.
Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila.
Isopentenyl-diphosphate isomerase is essential for viability of Caenorhabditis elegans.
CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo.
A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans.
A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.
Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans.
Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.
Is overoxidation of peroxiredoxin physiologically significant?
Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
The vitelliform macular dystrophy protein defines a new family of chloride channels.
RTEL-1 enforces meiotic crossover interference and homeostasis.
RTEL1 maintains genomic stability by suppressing homologous recombination.
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.
HCP-4, a CENP-C-like protein in Caenorhabditis elegans, is required for resolution of sister centromeres.
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.
Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase.
EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans.
Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.
Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.
A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans.
Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.
Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans.
Copulation in C. elegans males requires a nuclear hormone receptor.
Genetic transformation of the synaptic pattern of a motoneuron class in Caenorhabditis elegans.
UNC-55, an orphan nuclear hormone receptor, orchestrates synaptic specificity among two classes of motor neurons in Caenorhabditis elegans.
A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos.
Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.
The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission.
abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans.
Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system.
Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development.
The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.
Hox and a newly identified E2F co-repress cell death in Caenorhabditis elegans.
Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.
Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.
ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans.
A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo.
An early pharyngeal muscle enhancer from the Caenorhabditis elegans ceh-22 gene is targeted by the forkhead factor PHA-4.
Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans.
Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA.
Gland-specific expression of C. elegans hlh-6 requires the combinatorial action of three distinct promoter elements.
Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response.
PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut.
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.
Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans.
Temporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxA.
The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine.
The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans.
The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans.
Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.
pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx.
pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans.
Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1.
The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans.
Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.
Perinuclear anchoring of H3K9-methylated chromatin stabilizes induced cell fate in C. elegans embryos.
Protons act as a transmitter for muscle contraction in C. elegans.
C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides.
Deciphering the Role of EGL-3 for Neuropeptides Processing in Caenorhabditis elegans Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry.
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.
The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.
Lifespan regulation by evolutionarily conserved genes essential for viability.
Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome.
The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.
Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.
The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration.
The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.
A competition mechanism for a homeotic neuron identity transformation in C. elegans.
Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression.
Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons.
Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.
Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.
mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans.
Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator.
Characterization of Drosophila and Caenorhabditis elegans NXF-like-factors, putative homologs of mammalian NXF.
The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans.
The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior.
The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development.
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia.
Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.
The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.
A compartmentalized signaling network mediates crossover control in meiosis.
The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.
The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans.
Nuclear export of ubiquitinated proteins via the UBIN-POST system.
Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans.
Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans.
The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.
Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.
hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.
A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation.
A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.
Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
Comparative analysis of expression of two p97 homologues in Caenorhabditis elegans.
ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.
Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans.
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.
p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.
A robust network of double-strand break repair pathways governs genome integrity during C. elegans development.
BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.
BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis.
BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.
DNA strand breaks in mitotic germ cells of Caenorhabditis elegans evaluated by comet assay.
Developmental arrest of Caenorhabditis elegans BRAP-2 mutant exposed to oxidative stress is dependent on BRC-1.
Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.
HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes.
KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans.
The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli.
The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.
LINKIN, a new transmembrane protein necessary for cell adhesion.
The C. elegans genome sequencing project: a beginning.
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.
The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved.
The primary structure of histone H2A from the nematode Caenorhabditis elegans.
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.
Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans.
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases.
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans.
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
REI-1 is a guanine nucleotide exchange factor regulating RAB-11 localization and function in C. elegans embryos.
A cGMP-dependent protein kinase is implicated in wild-type motility in C. elegans.
A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans.
Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans.
Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.
Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans.
Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans.
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.
Nuclear PKG localization is regulated by G(0) alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans.
Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.
Parallel encoding of sensory history and behavioral preference during Caenorhabditis elegans olfactory learning.
The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.
The EGL-4 PKG acts with KIN-29 salt-inducible kinase and protein kinase A to regulate chemoreceptor gene expression and sensory behaviors in Caenorhabditis elegans.
The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans.
The importance of cGMP signaling in sensory cilia for body size regulation in Caenorhabditis elegans.
The receptor-bound guanylyl cyclase DAF-11 is the mediator of hydrogen peroxide-induced cGMP increase in Caenorhabditis elegans.
cGMP and a germ-line signal control body size in C. elegans through cGMP-dependent protein kinase EGL-4.
egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues.
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis.
SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.
A role for peroxidasin PXN-1 in aspects of C. elegans development.
Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.
The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration.
pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.
Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis.
Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans.
A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.
Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.
GON-1 and fibulin have antagonistic roles in control of organ shape.
Growth control by EGF repeats of the C. elegans Fibulin-1C isoform.
Identification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene.
MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.
Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.
Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.
Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.
Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.
N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.
Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase (PK-A) catalytic subunit gene (kin-1).
PKA controls calcium influx into motor neurons during a rhythmic behavior.
SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.
siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.
MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision.
CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.
CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.
Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.
Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans.
Genetic and phenotypic characterization of roller mutants of Caenorhabditis elegans.
The generation and genetic analysis of suppressors of lethal mutations in the Caenorhabditis elegans rol-3(V) gene.
Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2.
Riboflavin transporter-2 (rft-2) of Caenorhabditis elegans: Adaptive and developmental regulation.
The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.
The abts and sulp families of anion transporters from Caenorhabditis elegans.
Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.
A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response.
The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation.
The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences.
The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells.
Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.
Identification of new members of the (short) neuropeptide F family in locusts and Caenorhabditis elegans.
The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.
Functional assessment of Nramp-like metal transporters and manganese in Caenorhabditis elegans.
SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans.
The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in caenorhabditis elegans models of manganism and parkinson disease.
A unique serine-specific elongation factor Tu found in nematode mitochondria.
Identification of the residues involved in the unique serine specificity of Caenorhabditis elegans mitochondrial EF-Tu2.
C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint.
Molecular and genetic analyses of the Caenorhabditis elegans dpy-2 and dpy-10 collagen genes: a variety of molecular alterations affect organismal morphology.
Structural basis for the recruitment of glycogen synthase by glycogenin.
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.
The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans.
C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component.
eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans.
Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene.
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.
The small GTPase Arf1 modulates mitochondrial morphology and function.
A cellular and regulatory map of the cholinergic nervous system of C. elegans.
A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans.
Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel.
Extension of the mitochondrial transporter super-family: sequences of five members from the nematode worm, Caenorhabditis elegans.
A Disease Model of Muscle Necrosis Caused by Aeromonas dhakensis Infection in Caenorhabditis elegans.
Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1).
A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones.
Biosynthesis of Modular Ascarosides in C. elegans.
Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.
Cloning, baculovirus expression, and characterization of the alpha subunit of prolyl 4-hydroxylase from the nematode Caenorhabditis elegans. This alpha subunit forms an active alpha beta dimer with the human protein disulfide isomerase/beta subunit.
Prolyl 4-hydroxylase is an essential procollagen-modifying enzyme required for exoskeleton formation and the maintenance of body shape in the nematode Caenorhabditis elegans.
The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits.
Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution.
Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing.
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum.
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.
Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243.
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans.
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.
S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.
The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.
A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function.
Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development.
The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit.
The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.
V-ATPase V1 sector is required for corpse clearance and neurotransmission in Caenorhabditis elegans.
A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.
An interneuronal chemoreceptor required for olfactory imprinting in C. elegans.
Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans.
Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development.
Distinct innate immune responses to infection and wounding in the C. elegans epidermis.
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.
A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.
C. elegans ATAD-3 is essential for mitochondrial activity and development.
Caenorhabditis elegans ATAD-3 modulates mitochondrial iron and heme homeostasis.
MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans.
Paired and LIM class homeodomain proteins coordinate differentiation of the C. elegans ALA neuron.
The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans.
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.
A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.
Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.
Egg-laying defective mutants of the nematode Caenorhabditis elegans.
FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.
Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.
Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans.
Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans.
The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions.
The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans.
C. elegans BLOC-1 Functions in Trafficking to Lysosome-Related Gut Granules.
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.
Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo.
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.
Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.
Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.
Molecular and biochemical characterization of kettin in Caenorhabditis elegans.
Requirements of Kettin, a giant muscle protein highly conserved in overall structure in evolution, for normal muscle function, viability, and flight activity of Drosophila.
Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans.
Structural basis of eukaryotic cell-cell fusion.
The full-length cell-cell fusogen EFF-1 is monomeric and upright on the membrane.
The type I membrane protein EFF-1 is essential for developmental cell fusion.
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Shared gene expression in distinct neurons expressing common selector genes.
OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.
Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.
The primary structure of histone H4 from the nematode Caenorhabditis elegans.
An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.
Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.
Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.
Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.
Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.
The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans.
Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.
SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.
The Caenorhabditis elegans spe-39 gene is required for intracellular membrane reorganization during spermatogenesis.
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress.
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.
SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.
The role of dityrosine formation in the crosslinking of CUT-2, the product of a second cuticlin gene of Caenorhabditis elegans.
cut-1 a Caenorhabditis elegans gene coding for a dauer-specific noncollagenous component of the cuticle.
Caenorhabditis elegans UBC-2 functions with the anaphase-promoting complex but also has other activities.
Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.
The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.
Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans.
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.
Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release.
Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.
Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.
Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway.
The C. elegans discoidin domain receptor DDR-2 modulates the Met-like RTK-JNK signaling pathway in axon regeneration.
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.
The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade.
Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin.
A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.
New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.
lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein.
MSP domain proteins show enhanced expression in male germ line cells.
The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis.
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation.
CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron.
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.
Myoinhibitory peptide signaling modulates aversive gustatory learning in Caenorhabditis elegans.
Single-cell memory regulates a neural circuit for sensory behavior.
The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans.
The CaM kinase CMK-1 mediates a negative feedback mechanism coupling the C. elegans glutamate receptor GLR-1 with its own transcription.
The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance.
The signaling pathway of Caenorhabditis elegans mediates chemotaxis response to the attractant 2-heptanone in a Trojan horse-like pathogenesis.
A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene.
Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.
The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.
Protein tyrosine phosphatase domains from the protochordate Styela plicata.
Acute carbon dioxide avoidance in Caenorhabditis elegans.
Control of C. elegans larval development by neuronal expression of a TGF-beta homolog.
PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system.
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.
Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans.
mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans.
Characterization of the astacin family of metalloproteases in C. elegans.
A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans.
LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.
A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2.
Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.
DPY-27: a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.
Developmental dynamics of X-chromosome dosage compensation by the DCC and H4K20me1 in C. elegans.
H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation.
Cadmium-regulated genes from the nematode Caenorhabditis elegans. Identification and cloning of new cadmium-responsive genes by differential display.
Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity.
Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway.
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
CDK-11-Cyclin L is required for gametogenesis and fertility in C. elegans.
SPD-1 is required for the formation of the spindle midzone but is not essential for the completion of cytokinesis in C. elegans embryos.
The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.
C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.
EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose.
sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination.
sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis.
Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
Identification and characterization of Caenorhabditis elegans RNAi inheritance machinery.
MORC family ATPases required for heterochromatin condensation and gene silencing.
MORC-1 integrates nuclear RNAi and transgenerational chromatin architecture to promote germline immortality.
The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.
Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo.
PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans.
Basolateral targeting by leucine-rich repeat domains in epithelial cells.
Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.
Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.
LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans.
The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413.
Sperm chromatin proteomics identifies evolutionarily conserved fertility factors.
Sperm development and motility are regulated by PP1 phosphatases in Caenorhabditis elegans.
Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep.
Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans.
A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex switch gene.
CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.
Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex.
Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination.
Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans.
Molecular antagonism between X-chromosome and autosome signals determines nematode sex.
The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.
The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.
The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.
The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.
Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.
X-chromosome-counting mechanisms that determine nematode sex.
Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans.
Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1.
Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop.
Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans.
The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.
Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.
Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties.
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway.
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans.
Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate.
The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals.
Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis.
Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility.
TRY-5 Is a Sperm-Activating Protease in Caenorhabditis elegans Seminal Fluid.
The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction.
New role for DCR-1/dicer in Caenorhabditis elegans innate immunity against the highly virulent bacterium Bacillus thuringiensis DB27.
The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans.
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance.
Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease.
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Multiple forms of histone H2B from the nematode Caenorhabditis elegans.
The histones of Caenorhabditis elegans: no evidence of stage-specific isoforms. An overview.
2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans.
A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line.
A role for WDR5 in TRA-1/Gli mediated transcriptional control of the sperm/oocyte switch in C. elegans.
Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.
Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling.
Odd-skipped homologs function during gut development in C. elegans.
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.
Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins.
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex.
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon.
eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling.
Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6.
MEC-17 is an alpha-tubulin acetyltransferase.
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.
Nucleotide sequence of a cDNA clone encoding a Caenorhabditis elegans homolog of mammalian alkyl-dihydroxyacetonephosphate synthase: evolutionary switching of peroxisomal targeting signals.
Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.
A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning.
acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.
Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29.
Use of an activated beta-catenin to identify Wnt pathway target genes in caenorhabditis elegans, including a subset of collagen genes expressed in late larval development.
An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.
Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.
Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.
Structural basis for Ufm1 recognition by UfSP.
The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.
Caenorhabditis elegans embryos contain only one major species of Ro RNP.
The Caenorhabditis elegans rop-1 gene encodes the homologue of the human 60-kDa Ro autoantigen.
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.
Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis.
The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in C. elegans.
An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.
Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo.
Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D.
Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span.
Chondroitin acts in the guidance of gonadal distal tip cells in C. elegans.
Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division.
The C. elegans SYS-1 protein is a bona fide beta-catenin.
Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper.
Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.
Differential activation of 'social' and 'solitary' variants of the Caenorhabditis elegans G protein-coupled receptor NPR-1 by its cognate ligand AF9.
Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1.
The laboratory domestication of Caenorhabditis elegans.
A forward genetic screen for suppressors of somatic P granules in Caenorhabditis elegans.
A mechanistic basis for the coordinated regulation of pharyngeal morphogenesis in Caenorhabditis elegans by LIN-35/Rb and UBC-18-ARI-1.
A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.
C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination.
C. elegans class B synthetic multivulva genes act in G(1) regulation.
C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions.
CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.
Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.
Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.
Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.
Implicating SCF complexes in organogenesis in Caenorhabditis elegans.
LIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans.
Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.
Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes.
Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.
The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.
The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans.
The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans.
Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs.
XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans.
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C.elegans vulval development.
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen.
lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans.
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans.
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.
lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans.
lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.
lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development.
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.
Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.
Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family.
Ce-wts-1 plays important roles in Caenorhabditis elegans development.
Lats kinase is involved in the intestinal apical membrane integrity in the nematode Caenorhabditis elegans.
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
ATX-2, the C. elegans ortholog of human Ataxin-2, regulates centrosome size and microtubule dynamics.
Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors.
The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.
The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis.
Dynamic localization of SPE-9 in sperm: a protein required for sperm-oocyte interactions in Caenorhabditis elegans.
Functional domains and temperature-sensitive mutations in SPE-9, an EGF repeat-containing protein required for fertility in Caenorhabditis elegans.
Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis.
The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization.
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.
Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans.
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans.
Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.
The atm-1 gene is required for genome stability in Caenorhabditis elegans.
The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans.
A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans.
Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans.
Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans.
C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.
The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.
Structure and expression of the Caenorhabditis elegans protein kinase C2 gene. Origins and regulated expression of a family of Ca2+-activated protein kinase C isoforms.
Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogens.
The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection.
A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody.
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.
RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos.
RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin.
RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans.
Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans.
Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans.
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.
The C. elegans Rab family: Identification, classification and toolkit construction.
The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans.
mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.
An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse.
Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans.
Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.
PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans.
The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1.
pag-3, a Caenorhabditis elegans gene involved in touch neuron gene expression and coordinated movement.
unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans.
Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases.
FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.
Patterning of the C. elegans 1 degrees vulval lineage by RAS and Wnt pathways.
The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis.
NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation.
The neurexin superfamily of Caenorhabditis elegans.
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.
A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.
A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein.
C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.
CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans.
Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans.
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.
The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.
The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation.
The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome.
Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions.
Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Mitochondrial ubiquinone-mediated longevity is marked by reduced cytoplasmic mRNA translation.
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
Identification of a caenorhabditis elegans Delta6-fatty-acid-desaturase by heterologous expression in saccharomyces cerevisiae.
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling.
Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
Repression of the heat shock response is a programmed event at the onset of reproduction.
Active turnover modulates mature microRNA activity in Caenorhabditis elegans.
Functional genomic analysis of C. elegans molting.
PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.
Structural basis and function of XRN2 binding by XTB domains.
Target-mediated protection of endogenous microRNAs in C. elegans.
The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.
A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans.
AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans.
Gene regulatory logic of dopamine neuron differentiation.
Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit.
The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.
Homeobox containing genes in the nematode Caenorhabditis elegans.
Unique homeobox codes delineate all the neuron classes of C. elegans.
Identification of a family of animal sphingomyelin synthases.
ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans.
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein.
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.
[FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode.
Genetics: influence of TOR kinase on lifespan in C. elegans.
Small nucleoli are a cellular hallmark of longevity.
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation.
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.
A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.
C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis.
HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis.
Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans.
Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans.
Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.
The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage.
The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.
Transcription factor hlh-2/E/Daughterless drives expression of alpha integrin ina-1 during DTC migration in C. elegans.
bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans.
Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi.
Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family.
Gastrulation initiation in Caenorhabditis elegans requires the function of gad-1, which encodes a protein with WD repeats.
Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans.
The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.
A novel thioredoxin-like protein encoded by the C. elegans dpy-11 gene is required for body and sensory organ morphogenesis.
Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans.
LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.
Zygotic genome activation triggers chromosome damage and checkpoint signaling in C. elegans primordial germ cells.
chk-1 is an essential gene and is required for an S-M checkpoint during early embryogenesis.
A closed conformation of the Caenorhabditis elegans separase-securin complex.
Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase.
Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.
The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.
A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis.
Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans.
Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis.
Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.
Automated analysis of embryonic gene expression with cellular resolution in C. elegans.
Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.
The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification.
Tandemly duplicated Caenorhabditis elegans collagen genes differ in their modes of splicing.
Sequence comparison between the flavoprotein subunit of the fumarate reductase (complex II) of the anaerobic parasitic nematode, Ascaris suum and the succinate dehydrogenase of the aerobic, free-living nematode, Caenorhabditis elegans.
C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis.
Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.
Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans.
LEM-3 - a LEM domain containing nuclease involved in the DNA damage response in C. elegans.
MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.
MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans.
The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans.
Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos.
Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans.
The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos.
The Nrde pathway mediates small-RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans.
The polycomb group in Caenorhabditis elegans and maternal control of germline development.
Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins.
Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes.
DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration.
ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans.
Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.
MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans.
Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.
FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.
Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations.
Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans.
beta-Integrin de-phosphorylation by the density-enhanced phosphatase DEP-1 attenuates EGFR signaling in C. elegans.
EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.
Alteration of the DNA binding domain disrupts distinct functions of the C. elegans Pax protein EGL-38.
Characterization of seven genes affecting Caenorhabditis elegans hindgut development.
EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development.
EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions.
Pax2/5/8 proteins promote cell survival in C. elegans.
The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans.
The Pax2/5/8 gene egl-38 coordinates organogenesis of the C. elegans egg-laying system.
Mutagenic and chemical modification of the ABA-1 allergen of the nematode Ascaris: consequences for structure and lipid binding properties.
Sequence-divergent units of the ABA-1 polyprotein array of the nematode Ascaris suum have similar fatty-acid- and retinol-binding properties but different binding-site environments.
The ABA-1 allergen of the parasitic nematode Ascaris suum: fatty acid and retinoid binding function and structural characterization.
The DvA-1 polyprotein of the parasitic nematode Dictyocaulus viviparus. A small helix-rich lipid-binding protein.
The gp15/400 polyprotein antigen of Brugia malayi binds fatty acids and retinoids.
Global regulation of Hox gene expression in C. elegans by a SAM domain protein.
RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans.
SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
The C. elegans Polycomb gene sop-2 encodes an RNA binding protein.
Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.
Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.
Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.
Novel family of CCCH-type zinc-finger proteins, MOE-1, -2 and -3, participates in C. elegans oocyte maturation.
CPEB proteins control two key steps in spermatogenesis in C. elegans.
Transcriptional control of parallel-acting pathways that remove specific presynaptic proteins in remodeling neurons.
Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1.
Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.
Graded proteasome dysfunction in Caenorhabditis elegans activates an adaptive response involving the conserved skn-1 and elt-2 transcription factors and the autophagy-lysosome pathway.
cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.
Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis.
A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.
Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits.
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span.
How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans.
Oscillatory transepithelial H(+) flux regulates a rhythmic behavior in C. elegans.
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1.
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.
Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis.
Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans.
The complete family of genes encoding G proteins of Caenorhabditis elegans.
Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis.
Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.
Identification of a cysteine residue important for the ATPase activity of C. elegans fidgetin homologue.
Mutational analysis of the functional motifs in the ATPase domain of Caenorhabditis elegans fidgetin homologue FIGL-1: firm evidence for an intersubunit catalysis mechanism of ATP hydrolysis by AAA ATPases.
The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line.
Characterization of a novel C. elegans RGS protein with a C2 domain: evidence for direct association between C2 domain and Galphaq subunit.
A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway.
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.
Caenorhabditis elegans UBC-1, a ubiquitin-conjugating enzyme homologous to yeast RAD6/UBC2, contains a novel carboxy-terminal extension that is conserved in nematodes.
Interactions within the ubiquitin pathway of Caenorhabditis elegans.
Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development.
Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7.
Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).
Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans.
Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP.
Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins.
Parasite-specific immunomodulatory functions of filarial cystatin.
The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization.
Expression pattern of the C. elegans p21-activated protein kinase, CePAK.
Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.
Distinct requirements for C.elegans TAF(II)s in early embryonic transcription.
The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.
The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons.
mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development.
mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans.
A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.
Cloning, structure, and expression of the gene for a novel regulatory subunit of cAMP-dependent protein kinase in Caenorhabditis elegans.
Differential requirements for STRAD in LKB1-dependent functions in C. elegans.
FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.
Folliculin regulates ampk-dependent autophagy and metabolic stress survival.
TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.
Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.
The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans.
Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.
Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation.
Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria.
C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types.
Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.
Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo.
Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.
Caenorhabditis elegans TRPA-1 functions in mechanosensation.
Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins.
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
The C. elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells.
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3.
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.
A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription.
Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4.
A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans.
C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.
The C. elegans taste receptor homolog LITE-1 is a photoreceptor.
Visible light reduces C. elegans longevity.
Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans.
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.
The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.
Expression of ram-5 in the structural cell is required for sensory ray morphogenesis in Caenorhabditis elegans male tail.
CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.
A Krueppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.
A Krueppel-like factor in Caenorhabditis elegans with essential roles in fat regulation, cell death, and phagocytosis.
KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants.
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.
Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans.
Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport.
Hierarchical assembly of presynaptic components in defined C. elegans synapses.
SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans.
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.
A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans.
An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in C. elegans.
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.
A novel C. elegans zinc finger transcription factor, lsy-2, required for the cell type-specific expression of the lsy-6 microRNA.
LSY-2 is essential for maintaining the germ-soma distinction in C. elegans.
LAB-1 antagonizes the Aurora B kinase in C. elegans.
Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.
The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing.
C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans.
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans.
A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.
Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes.
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.
Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization.
The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity.
The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans.
Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships.
Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline.
Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis.
A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3.
Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery.
The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation.
C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.
Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells.
UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.
Actin gene family of Caenorhabditis elegans.
Wild-type and mutant actin genes in Caenorhabditis elegans.
SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.
The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus.
The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.
The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans.
A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development.
daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase.
A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans.
Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association.
A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans.
Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.
The C. elegans NR4A nuclear receptor gene nhr-6 promotes cell cycle progression in the spermatheca lineage.
The Caenorhabditis elegans NR4A nuclear receptor is required for spermatheca morphogenesis.
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans.
Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia.
Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.
The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.
PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.
A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.
Organ length control by an ADAMTS extracellular protease in Caenorhabditis elegans.
Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans.
Stage-specific activation of MIG-17/ADAMTS controls cell migration in Caenorhabditis elegans.
The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans.
The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans.
Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1.
C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling.
Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development.
Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk).
The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells.
lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development.
A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans.
APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.
The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance.
Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development.
A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.
Genetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3 and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans.
Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans.
Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.
Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.
A left/right asymmetric neuronal differentiation program is controlled by the Caenorhabditis elegans lsy-27 zinc-finger transcription factor.
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.
Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.
Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.
Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans.
The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans.
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.
Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.
Correction: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans.
Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Characterization of a novel serotonin receptor from Caenorhabditis elegans: cloning and expression of two splice variants.
The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.
Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing.
Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms.
Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling.
Spastin binds to lipid droplets and affects lipid metabolism.
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
The C-terminal alpha-helix of SPAS-1, a Caenorhabditis elegans spastin homologue, is crucial for microtubule severing.
The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.
lir-2, lir-1 and lin-26 encode a new class of zinc-finger proteins and are organized in two overlapping operons both in Caenorhabditis elegans and in Caenorhabditis briggsae.
NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength.
Genesis of an organ: molecular analysis of the pha-1 gene.
pha-1, a selectable marker for gene transfer in C. elegans.
Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity.
A novel sulfotransferase abundantly expressed in the dauer larvae of Caenorhabditis elegans.
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants.
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
N-glycosylation is required for secretion and mitosis in C. elegans.
The Rho/Rac family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in Caenorhabditis elegans.
A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
DLK-1/p38 MAP Kinase signaling controls cilium length by regulating RAB-5 mediated endocytosis in Caenorhabditis elegans.
Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.
Scavengers of reactive gamma-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7.
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
Asymmetric cortical and nuclear localizations of WRM-1/beta-catenin during asymmetric cell division in C. elegans.
Binary specification of the embryonic lineage in Caenorhabditis elegans.
C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm.
Identification of C. elegans DAF-12-binding sites, response elements, and target genes.
Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway.
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans.
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.
Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.
emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.
Conserved gene regulatory module specifies lateral neural borders across bilaterians.
Genes regulating touch cell development in Caenorhabditis elegans.
Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans.
CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits.
Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans.
The C. elegans unc-104 gene encodes a putative kinesin heavy chain-like protein.
Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components.
UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting.
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity.
Isolation and characterization of a sperm-specific gene family in the nematode Caenorhabditis elegans.
Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.
Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.
C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions.
Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.
A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration.
Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host.
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.
The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals.
Cysteine protease cathepsin B mediates radiation-induced bystander effects.
Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans.
The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance.
Cloning and characterization of the C. elegans gas1 homolog: phas-1.
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
Comparisons of the complete sequences of two collagen genes from Caenorhabditis elegans.
Expression of the Caenorhabditis elegans collagen genes col-1 and col-2 is developmentally regulated.
Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.
Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.
A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans.
The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans.
Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases.
The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis.
The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells.
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.
Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.
The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly.
C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.
Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development.
Role of the C. elegans U2 snRNP protein MOG-2 in sex determination, meiosis, and splice site selection.
A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans.
A continuum of mRNP complexes in embryonic microRNA-mediated silencing.
Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.
The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans.
Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence.
srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates.
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans.
Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner.
A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.
Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.
The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.
The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans.
Luqin-like RYamide peptides regulate food-evoked responses in C. elegans.
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans.
Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying.
Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans.
Control of cell fate in the tail region of C. elegans by the gene egl-5.
EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.
Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5.
The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum.
The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.
The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.
The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.
Gene conversion and DNA sequence polymorphism in the sex-determination gene fog-2 and its paralog ftr-1 in Caenorhabditis elegans.
Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans.
In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin.
SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans.
The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.
Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans.
Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.
Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis.
A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein.
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
Studies of SARM1 uncover similarities between immune and neuronal responses to danger.
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.
A newly formed telomere in Ascaris suum does not exert a telomere position effect on a nearby gene.
Caenorhabditis cDNA encodes an eIF-4A-like protein.
A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.
A role for C. elegans Eph RTK signaling in PTEN regulation.
An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans.
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans.
Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.
Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases.
A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.
C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.
Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.
Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.
Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.
SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.
SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.
UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.
The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.
Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans.
Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans.
Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos.
The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase.
The alpha and beta subunits of nematode actin capping protein function in yeast.
Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans.
Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.
ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.
C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line.
LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron.
Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans: a new gene, vha-3, has a distinct cell-specific distribution.
Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans.
Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans.
The Caenorhabditis elegans distal-less ortholog ceh-43 is required for development of the anterior hypodermis.
Circadian rhythms identified in Caenorhabditis elegans by in vivo long-term monitoring of a bioluminescent reporter.
Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachment.
HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans.
Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20.
The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm.
The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.
Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.
Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase1.
Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans.
Genetic regulation of Caenorhabditis elegans lysosome related organelle function.
Isolation, pharmacology and gene organization of KPSFVRFamide: a neuropeptide from Caenorhabditis elegans.
Characterisation of ZK643-3: a putative 7TM neuropeptide receptor.
The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm.
The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.
The SEM-4 Transcription Factor Is Required for Regulation of the Oxidative Stress Response in Caenorhabditis elegans.
sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.
Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins.
UEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neurons.
Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.
Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans.
EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans.
The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G protein signaling proteins egl-10 and eat-16.
Two conserved epigenetic regulators prevent healthy ageing.
Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.
Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins.
RNA-Regulated TRA-1 nuclear export controls sexual fate.
The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.
The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.
Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro.
dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans.
Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons.
Germ-line regulation of the Caenorhabditis elegans sex-determining gene tra-2.
Molecular analysis of tra-2, a sex determining gene in C.elegans.
Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3.
Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3.
Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2.
tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.
Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans.
The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.
Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axons.
The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component.
Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization.
Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.
The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression.
daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan.
A pathway for phagosome maturation during engulfment of apoptotic cells.
Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans.
Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.
Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegans.
The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development.
The C. elegans ceh-36 gene encodes a putative homeodomain transcription factor involved in chemosensory functions of ASE and AWC neurons.
Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.
The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination.
Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans.
Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly.
The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules.
Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans.
A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.
Differentiation of carbon dioxide-sensing neurons in Caenorhabditis elegans requires the ETS-5 transcription factor.
Lineage context switches the function of a C. elegans Pax6 homolog in determining a neuronal fate.
The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety.
Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation.
DNA Methylation on N(6)-Adenine in C. elegans.
Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.
UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles.
A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development.
The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans.
A family of unconventional myosins from the nematode Caenorhabditis elegans.
A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes.
Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology.
DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif.
Interference between the PHA-4 and PEB-1 transcription factors in formation of the Caenorhabditis elegans pharynx.
The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut.
The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor.
Deficiency of alpha-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans.
Caenorhabditis elegans contains structural homologs of human prk and plk.
PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25.
PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos.
Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans.
Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.
SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression.
The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.
Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans.
ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans.
Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7.
Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.
A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline.
RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans.
MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans.
A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans.
Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1.
DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.
Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.
Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells.
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
Genomic structure of a cytoplasmic dynein heavy chain gene from the nematode Caenorhabditis elegans.
The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos.
The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans.
atz-1 Influences meiosis to maintain germline chromosomal stability in Caenorhabditis elegans.
Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42.
Genes that guide growth cones along the C. elegans ventral nerve cord.
The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression.
The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes.
The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons.
A feedback loop governs the relationship between lipid metabolism and longevity.
Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.
The mitochondrial unfolded protein response protects against anoxia in Caenorhabditis elegans.
Molecular analysis of Caenorhabditis elegans tcp-1, a gene encoding a chaperonin protein.
Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+.
CLC anion channel regulatory phosphorylation and conserved signal transduction domains.
CLC chloride channels in Caenorhabditis elegans.
CLH-3, a ClC-2 anion channel ortholog activated during meiotic maturation in C. elegans oocytes.
Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.
Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity.
GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.
Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel.
Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression.
The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability.
Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker.
The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans.
Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia.
TFG-1 function in protein secretion and oncogenesis.
The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans.
Sequence-specific binding to telomeric DNA by CEH-37, a homeodomain protein in the nematode Caenorhabditis elegans.
Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.
Functional Interplay of Two Paralogs Encoding SWI/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development.
LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.
The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation.
Molecular analysis of mutations in the Caenorhabditis elegans collagen gene dpy-7.
Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans.
A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo.
A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo.
An E-cadherin-mediated hitchhiking mechanism for C. elegans germ cell internalization during gastrulation.
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.
In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans.
SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.
The C. elegans hmr-1 gene can encode a neuronal classic cadherin involved in the regulation of axon fasciculation.
The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis.
ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions.
Cloning and analysis of cDNA sequences coding for two 16 kilodalton heat shock proteins (hsps) in Caenorhabditis elegans: homology with the small hsps of Drosophila.
Locus encoding a family of small heat shock genes in Caenorhabditis elegans: two genes duplicated to form a 3.8-kilobase inverted repeat.
Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors.
Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans.
KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC.
The MADS-Box factor CeMEF2 is not essential for Caenorhabditis elegans myogenesis and development.
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
Protein L-isoaspartyl methyltransferase from the nematode Caenorhabditis elegans: genomic structure and substrate specificity.
Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.
Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.
The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology.
The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.
Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression.
OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans.
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
A Caenorhabditis elegans homeobox gene expressed in the male tail, a link between pattern formation and sexual dimorphism?
The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development.
Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans.
Lipocalin signaling controls unicellular tube development in the Caenorhabditis elegans excretory system.
The hedgehog-related gene wrt-5 is essential for hypodermal development in Caenorhabditis elegans.
The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.
Neuronal calmodulin levels are controlled by CAMTA transcription factors.
C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning.
Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.
Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes.
Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.
DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.
Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos.
Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.
The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
Cornichons control ER export of AMPA receptors to regulate synaptic excitability.
RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.
MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein.
An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.
Identification and characterization of the SMT3 cDNA and gene from nematode Caenorhabditis elegans.
Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.
SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans.
A conserved ubiquitination pathway determines longevity in response to diet restriction.
WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development.
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component.
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
The Caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut.
Three novel T-box genes in Caenorhabditis elegans.
The C. elegans T-type calcium channel CCA-1 boosts neuromuscular transmission.
Functional coordination of intraflagellar transport motors.
Functional genomics of the cilium, a sensory organelle.
The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation.
The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor.
Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.
The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis.
Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins.
Muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins.
A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans.
HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.
Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.
Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2.
The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication.
A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans.
Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.
High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLD-1, STAR-2 and Quaking.
Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo.
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa.
Filamin and phospholipase C-epsilon are required for calcium signaling in the Caenorhabditis elegans spermatheca.
A Conserved role for girdin in basal body positioning and ciliogenesis.
Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans.
Identification of lineage-specific zygotic transcripts in early Caenorhabditis elegans embryos.
The noncanonical binding site of the MED-1 GATA factor defines differentially regulated target genes in the C. elegans mesendoderm.
A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans.
The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons.
A novel bipartite UNC-101/AP-1 mu1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.
Synaptic vesicle fusion is modulated through feedback inhibition by dopamine auto-receptors.
NOCA-1 Functions with gamma-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.
Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation.
Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues.
Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.
Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions.
The C. elegans Hand gene controls embryogenesis and early gonadogenesis.
Regulatory myosin light-chain genes of Caenorhabditis elegans.
Characterization of the C. elegans erlin homologue.
The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins.
Isolation of the interacting molecules with GEX-3 by a novel functional screening.
Netrin (UNC-6) mediates dendritic self-avoidance.
The receptor protein tyrosine phosphatase CLR-1 is required for synaptic partner recognition.
UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues.
UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.
OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans.
AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans.
Glia delimit shape changes of sensory neuron receptive endings in C. elegans.
The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX.
H+/myo-inositol transporter genes, hmit-1.1 and hmit-1.2, have roles in the osmoprotective response in Caenorhabditis elegans.
AMP-activated kinase regulates lipid droplet localization and stability of adipose triglyceride lipase in C. elegans dauer larvae.
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
The causative gene in Chanarian Dorfman syndrome regulates lipid droplet homeostasis in C. elegans.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.
EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.
HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.
Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.
Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.
Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.
Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.
Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.
Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants.
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.
Casein kinase II and calcineurin modulate TRPP function and ciliary localization.
General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.
STAM and Hrs down-regulate ciliary TRP receptors.
The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans.
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans.
First crystal structure of a medicinally relevant gold protein complex: unexpected binding of [Au(PEt3)]+ to histidine.
Mutations in beta-spectrin disrupt axon outgrowth and sarcomere structure.
A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.
Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans.
Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane.
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells.
Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans.
Characterization of the hsp70 multigene family of Caenorhabditis elegans.
The Caenorhabditis elegans protein FIC-1 is an AMPylase that covalently modifies heat-shock 70 family proteins, translation elongation factors and histones.
Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.
Germ-granule components prevent somatic development in the C. elegans germline.
PGL germ granule assembly protein is a base-specific, single-stranded RNase.
PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans.
Polar positioning of phase-separated liquid compartments in cells regulated by an mRNA competition mechanism.
Selective autophagic degradation of maternally-loaded germline P granule components in somatic cells during C. elegans embryogenesis.
The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline development.
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
Distinct roles for two C. elegans anillins in the gonad and early embryo.
Am. J. Med. Genet. B Neuropsychiatr. Genet.
A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling.
CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-beta expression.
Differential Regulation of Innate and Learned Behavior by Creb1/Crh-1 in Caenorhabditis elegans.
Genetic dissection of memory for associative and non-associative learning in Caenorhabditis elegans.
Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments?
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Fatty acid- and retinoid-binding proteins have distinct binding pockets for the two types of cargo.
Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.
Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.
Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.
Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.
Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans.
Bisecting Galactose as a Feature of N-Glycans of Wild-type and Mutant Caenorhabditis elegans.
Comparisons of Caenorhabditis fucosyltransferase mutants reveal a multiplicity of isomeric N-Glycan structures.
Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10.
The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23.
The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos.
The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis.
Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans.
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans.
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
HIF-1 modulates longevity and healthspan in a temperature-dependent manner.
HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.
Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel-Lindau tumor suppressor-1 in C. elegans.
Hypoxia activates a latent circuit for processing gustatory information in C. elegans.
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity.
A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling.
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans.
Differential expression pattern of UBX family genes in Caenorhabditis elegans.
New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.
A non-cell-autonomous role for Ras signaling in C. elegans neuroblast delamination.
An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.
Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.
Genes required for axon pathfinding and extension in the C. elegans nerve ring.
Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase.
Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase.
Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family.
CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors.
Secretion of a novel class of iFABPs in nematodes: coordinate use of the Ascaris/Caenorhabditis model systems.
C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.
Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.
RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans.
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis.
The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome.
The role of RNA editing by ADARs in RNAi.
Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans.
Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B'' subunit targeting of PP2A to centrosomes in C. elegans.
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes.
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo.
CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.
The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane.
The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.
Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.
LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms.
Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.
Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis.
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation.
The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
When LIN41 comes to a fork in the road, it takes BOTH paths: translational repression OR mRNA decay, depending on the target site position.
let-7 coordinates the transition to adulthood through a single primary and four secondary targets.
The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II.
A map of the interactome network of the metazoan C. elegans.
Asymmetric division: a kinesin for spindle positioning.
Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.
Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter.
Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling.
Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans.
Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.
MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans.
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.
Notch signalling is required for both dauer maintenance and recovery in C. elegans.
Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.
Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans.
lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans.
ICln ion channel splice variants in Caenorhabditis elegans: voltage dependence and interaction with an operon partner protein.
Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans.
EAT-20, a novel transmembrane protein with EGF motifs, is required for efficient feeding in Caenorhabditis elegans.
Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans.
7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity.
Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS.
A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity.
A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans.
Maternal mRNAs are regulated by diverse P body-related mRNP granules during early Caenorhabditis elegans development.
The RNA-binding proteins PUF-5, PUF-6, and PUF-7 reveal multiple systems for maternal mRNA regulation during C. elegans oogenesis.
A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans.
Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126).
Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans.
Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos.
Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.
Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.
Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.
Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.
Mutations in synaptojanin disrupt synaptic vesicle recycling.
Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism.
A C. elegans gene encodes a protein homologous to mammalian calreticulin.
Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis.
CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development.
Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.
Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans.
A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans.
Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis.
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
The Caenorhabditis elegans SCC-3 homologue is required for meiotic synapsis and for proper chromosome disjunction in mitosis and meiosis.
Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.
GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.
The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation.
Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution.
A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans.
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression.
The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling.
The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.
KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation.
Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2).
Evolution tunes the excitability of individual neurons.
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.
A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans.
PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans.
Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.
Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene.
GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.
Separable roles for a Caenorhabditis elegans RMI1 homolog in promoting and antagonizing meiotic crossovers ensure faithful chromosome inheritance.
The SMC-5/6 complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during Caenorhabditis elegans meiosis.
REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity.
An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons.
Co-chaperone p23 regulates C. elegans lifespan in response to temperature.
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans.
Mutations affecting the chemosensory neurons of Caenorhabditis elegans.
Sensory control of dauer larva formation in Caenorhabditis elegans.
The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1.
Balancing selection shapes density-dependent foraging behaviour.
Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior.
Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.
The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans.
Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.
In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system.
Most genes encoding cytoplasmic intermediate filament (IF) proteins of the nematode Caenorhabditis elegans are required in late embryogenesis.
A Caenorhabditis elegans prospero homologue defines a novel domain.
A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation.
Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1.
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.
Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4.
LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.
The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type.
Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior.
Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.
DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.
Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion.
A histone-H3-like protein in C. elegans.
Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis.
Functional analysis of kinetochore assembly in Caenorhabditis elegans.
Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.
MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance.
A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. elegans.
Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans.
Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.
emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6.
An intestinally secreted host factor promotes microsporidia invasion of C. elegans.
Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements.
Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.
UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein.
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis.
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans.
Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1.
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry.
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Calcineurin regulates enteric muscle contraction through EXP-1, excitatory GABA-gated channel, in C. elegans.
EXP-1 is an excitatory GABA-gated cation channel.
Genetic analysis of defecation in Caenorhabditis elegans.
Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans.
NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.
Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans.
The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.
An RNA-Binding Multimer Specifies Nematode Sperm Fate.
The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans.
lis-1 is required for dynein-dependent cell division processes in C. elegans embryos.
Crystal structure of the Golgi casein kinase.
UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm.
The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans.
The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system.
mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans.
The conserved wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.
The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit.
Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability.
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans.
Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape.
Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase.
Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo.
The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis.
Serine hydroxymethyltransferase is maternally essential in Caenorhabditis elegans.
A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit.
Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1.
Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan.
A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.
Endoderm development in Caenorhabditis elegans: the synergistic action of ELT-2 and -7 mediates the specification-differentiation transition.
Mode of bacterial pathogenesis determines phenotype in elt-2 and elt-7 RNAi Caenorhabditis elegans.
The Function and Regulation of the GATA Factor ELT-2 in the C. elegans Endoderm.
Transdifferentiation and remodeling of post-embryonic C. elegans cells by a single transcription factor.
MTD-1, a touch-cell-specific membrane protein with a subtle effect on touch sensitivity.
C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor.
AIR-2: an Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos.
CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1.
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.
Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.
Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development.
The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.
The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles.
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.
The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis.
The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.
Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.
A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.
The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans.
Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan.
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.
DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.
Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans.
nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival.
A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans.
Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.
The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor.
Inducible antibacterial defense system in C. elegans.
Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis.
RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation.
Cloning by synteny: identifying C. briggsae homologues of C. elegans genes.
Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2.
H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.
Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.
Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans.
Multiple regulatory changes contribute to the evolution of the Caenorhabditis lin-48 ovo gene.
The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans.
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2.
Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.
DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline.
Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans.
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage.
Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development.
Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68.
Structural and functional implications of the QUA2 domain on RNA recognition by GLD-1.
Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation.
Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.
Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis.
A novel role for the zinc-finger transcription factor EGL-46 in the differentiation of gas-sensing neurons in Caenorhabditis elegans.
Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.
Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans.
Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin.
Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4.
Mechanistic insights into central spindle assembly mediated by the centralspindlin complex.
Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans.
Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation.
Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.
The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.
A novel type of RNase III family proteins in eukaryotes.
Processing of primary microRNAs by the Microprocessor complex.
ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression.
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.
Mutants of Caenorhabditis elegans that form dauer-like larvae.
SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans.
The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption.
CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.
A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.
Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains.
Ubiquitination is required for the initial removal of paternal organelles in C. elegans.
A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality.
An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos.
Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells.
OMA-1 is a P granules-associated protein that is required for germline specification in Caenorhabditis elegans embryos.
RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1.
Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans.
zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression.
Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans.
Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.
Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B.
A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity.
RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans.
The jaw of the worm: GTPase-activating protein EAT-17 regulates grinder formation in Caenorhabditis elegans.
The four cdc25 genes from the nematode Caenorhabditis elegans.
cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis.
A direct interaction between IP(3) receptors and myosin II regulates IP(3) signaling in C. elegans.
Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family.
Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.
aex-3 encodes a novel regulator of presynaptic activity in C. elegans.
The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.
TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans.
Two Rab2 interactors regulate dense-core vesicle maturation.
The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.
The manganese superoxide dismutase gene of Caenorhabditis elegans.
Role of a new Rho family member in cell migration and axon guidance in C. elegans.
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets.
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.
Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway.
The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs.
The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification.
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
The vasa homolog rde-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans.
The primary structure of a minor isoform (H1.2) of histone H1 from the nematode Caenorhabditis elegans.
Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans.
The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways.
Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.
Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level.
Extracellular proteins needed for C. elegans mechanosensation.
Identification of an endo-beta-N-acetylglucosaminidase gene in Caenorhabditis elegans and its expression in Escherichia coli.
A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons.
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
A redox signalling globin is essential for reproduction in Caenorhabditis elegans.
Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin.
Isolation of a cDNA encoding a Kex2-like endoprotease with homology to furin from the nematode Caenorhabditis elegans.
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans.
DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development.
Linking the environment, DAF-7/TGFbeta signaling and LAG-2/DSL ligand expression in the germline stem cell niche.
The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx.
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.
A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11.
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity.
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.
The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.
High-throughput in vivo analysis of gene expression in Caenorhabditis elegans.
Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.
Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans.
The anaphase-promoting complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction.
The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation.
The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans.
Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans.
Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan.
Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.
A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans.
Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8.
Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network.
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.
RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans.
RIC-8 (Synembryn): a novel conserved protein that is required for Gq alpha signaling in the C. elegans nervous system.
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans.
A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans.
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans.
Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.
cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.
Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family.
Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans.
A chemoreceptor that detects molecular carbon dioxide.
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function.
The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.
Autophagy regulates ageing in C. elegans.
Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans.
HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1.
The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental timing that acts independently of its predicted pump function.
Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions.
Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae.
CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.
CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.
Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis.
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.
Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.
C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain.
UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans.
LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans.
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.
The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Two classes of active transcription sites and their roles in developmental regulation.
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans.
Reverse genetics by chemical mutagenesis in Caenorhabditis elegans.
HES-Mediated Repression of Pten in Caenorhabditis elegans.
Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.
Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development.
dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates.
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.
Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases.
Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans.
Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release.
Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.
Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males.
Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans.
Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans.
MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans.
SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans.
Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans.
Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans.
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.
Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family.
sma-1 encodes a betaH-spectrin homolog required for Caenorhabditis elegans morphogenesis.
ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.
Developmental defects in a Caenorhabditis elegans model for type III galactosemia.
An SLC6 transporter of the novel B(0,)- system aids in absorption and detection of nutrient amino acids in Caenorhabditis elegans.
The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply.
Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme.
An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom.
Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties.
Neurobeachin: a protein kinase A-anchoring, beige/Chediak-Higashi protein homolog implicated in neuronal membrane traffic.
SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells.
Genomic structure of three CLN3-like genes in Caenorhabditis elegans.
Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity and immune response of Caenorhabditis elegans through a nuclear hormone receptor.
Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans.
A measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.
Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS.
Aging and resistance to oxidative damage in Caenorhabditis elegans.
MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.
Redox regulation of germline and vulval development in Caenorhabditis elegans.
The copper/zinc superoxide dismutase gene of Caenorhabditis elegans.
Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans.
Caenorhabditis elegans has two genes encoding functional D-aspartate oxidases.
Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans.
Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans.
Caenorhabditis elegans ubiquinone biosynthesis genes.
A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.
Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans.
TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons.
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species.
A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans.
The identification of a novel mutant allele of topoisomerase II in Caenorhabditis elegans reveals a unique role in chromosome segregation during spermatogenesis.
cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis.
An acid phosphatase as a biochemical marker for intestinal development in the nematode Caenorhabditis elegans.
Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine.
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.
Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.
Whole-organism developmental expression profiling identifies rab-28 as a novel ciliary GTPase associated with the BBSome and intraflagellar transport.
An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans.
Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans.
Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age.
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins.
C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.
Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning.
Localized TWIST1 and TWIST2 basic domain substitutions cause four distinct human diseases that can be modeled in Caenorhabditis elegans.
CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans.
Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium.
SID-1 Domains Important for dsRNA Import in Caenorhabditis elegans.
The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans.
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.
CUTI-1: A novel tetraspan protein involved in C. elegans CUTicle formation and epithelial integrity.
Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
Axon regeneration pathways identified by systematic genetic screening in C. elegans.
Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.
Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.
Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis.
Cloning, characterisation and crystallisation of a diadenosine 5',5''-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans.
Crystallization of a complex of Caenorhabditis elegans diadenosine tetraphosphate hydrolase and a non-hydrolysable substrate analogue, AppCH2ppA.
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence.
A novel alpha1,2-fucosyltransferase (CE2FT-2) in Caenorhabditis elegans generates H-type 3 glycan structures.
The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1.
A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans.
The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein.
Correction: Neuroendocrine modulation sustains the C. elegans forward motor state.
Mutations affecting embryonic cell migrations in Caenorhabditis elegans.
Neuroendocrine modulation sustains the C. elegans forward motor state.
UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation.
Caenorhabditis elegans contains two distinct acid sphingomyelinases.
Expression of intron-containing C. elegans heat shock genes in mouse cells demonstrates divergence of 3' splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus.
A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.
Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1.
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism.
Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).
UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscle.
pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans.
A novel role for alpha-importins and Akirin in establishment of meiotic sister chromatid cohesion in Caenorhabditis elegans.
Akirin is required for muscle function and acts through the TGF-beta Sma/Mab signaling pathway in Caenorhabditis elegans development.
akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I.
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells.
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment.
Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.
Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.
Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily.
A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons.
Asymmetric distribution of the C. elegans HAM-1 protein in neuroblasts enables daughter cells to adopt distinct fates.
C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division.
C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.
The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell.
Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase.
Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.
The basal component of the nematode dense-body is vinculin.
SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins.
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling.
The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad.
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes.
A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.
Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior.
Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, members of a Nudix hydrolase subfamily.
Activation of hypodermal differentiation in the Caenorhabditis elegans embryo by GATA transcription factors ELT-1 and ELT-3.
ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos.
Regulation of sperm gene expression by the GATA factor ELT-1.
The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.
The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion.
The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.
elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family.
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans.
The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krueppel-like zinc finger protein MNM-2.
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import.
Steroids as central regulators of organismal development and lifespan.
Combined informatic and expression screen identifies the novel DAF-16 target HLH-13.
Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse.
Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development.
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
Characterization of a tyramine receptor from Caenorhabditis elegans.
Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans.
GPA-14, a Galpha(i) subunit mediates dopaminergic behavioral plasticity in C. elegans.
The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a Galphai subunit.
C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion.
Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins.
Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion.
Characterization of a G-protein alpha-subunit gene from the nematode Caenorhabditis elegans.
Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans.
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Differential sulfations and epimerization define heparan sulfate specificity in nervous system development.
Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans.
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.
An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways.
Polarized myosin produces unequal-size daughters during asymmetric cell division.
The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions.
Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans.
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.
EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans.
Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition.
Structural genomics of Caenorhabditis elegans: crystal structure of calmodulin.
Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8.
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans.
Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I.
Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans.
New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones.
A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line.
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans.
GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans.
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans.
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains.
The C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.
The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.
The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.
The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling.
GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.
Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.
The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development.
The hedgehog-related gene qua-1 is required for molting in Caenorhabditis elegans.
The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion.
ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans.
A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans.
A C. elegans mutant that lives twice as long as wild type.
A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans.
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.
Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.
Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans.
Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis.
Feeding state, insulin and NPR-1 modulate Chemoreceptor gene expression via integration of sensory and circuit inputs.
Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans.
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans.
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals.
Opposing activities protect against age-onset proteotoxicity.
Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions.
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
RPN-6 determines C. elegans longevity under proteotoxic stress conditions.
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.
Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
Stress-response protein expression and DAF-16 translocation were induced in tributyltin-exposed Caenorhabditis elegans.
The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.
The DAF-16/FOXO transcription factor functions as a regulator of epidermal innate immunity.
The FOXO transcription factor DAF-16 bypasses ire-1 requirement to promote endoplasmic reticulum hoymeostasis.
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei.
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan.
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery.
FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans.
A role for dynein in the inhibition of germ cell proliferative fate.
METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.
SDN-1/Syndecan acts in parallel to the transmembrane molecule MIG-13 to promote anterior neuroblast migration.
A C. elegans CLIC-like protein required for intracellular tube formation and maintenance.
Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans.
SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice.
Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED.
Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.
FEM1 proteins are ancient regulators of SLBP degradation.
Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.
The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.
The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.
The product of fem-1, a nematode sex-determining gene, contains a found in cell cycle control proteins and receptors for cell-cell interactions.
Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo.
Mutant sensory cilia in the nematode Caenorhabditis elegans.
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.
Striated rootlet and nonfilamentous forms of rootletin maintain ciliary function.
Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis.
Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.
Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans.
C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.
The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.
The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.
vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity.
A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.
C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division.
Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties.
Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion.
Metabotropic GABA signalling modulates longevity in C. elegans.
Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons.
Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.
Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.
MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans.
The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex.
Identification of a homeobox-containing gene located between lin-45 and unc-24 on chromosome IV in the nematode Caenorhabditis elegans.
The Caenorhabditis elegans homeobox gene ceh-19 is required for MC motorneuron function.
PKC-1 regulates secretion of neuropeptides.
The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction.
acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction.
The C. elegans gene lin-9, which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein.
Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7.
Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans.
APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development.
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans.
The DSL ligand APX-1 is required for normal ovulation in C. elegans.
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo.
Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo.
Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.
The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis.
Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans.
A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities.
New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.
Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development.
The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval-uterine-epidermal connections.
The LIN-29 transcription factor is required for proper morphogenesis of the Caenorhabditis elegans male tail.
The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans.
The terminal differentiation factor LIN-29 is required for proper vulval morphogenesis and egg laying in Caenorhabditis elegans.
Identification of the copper chaperone, CUC-1, in Caenorhabditis elegans: tissue specific co-expression with the copper transporting ATPase, CUA-1.
Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions.
Allele-specific phenotype suggests a possible stimulatory activity of rcan-1 on calcineurin in Caenorhabditis elegans.
Autophagy genes mediate the effect of calcineurin on life span in C. elegans.
CNP-1 (ARRD-17), a novel substrate of calcineurin, is critical for modulation of egg-laying and locomotion in response to food and lysine sensation in Caenorhabditis elegans.
Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans.
Calcineurin may regulate multiple endocytic processes in C. elegans.
Calcineurin regulates coelomocyte endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans.
Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans.
Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6.
Novel calcineurin interacting protein-2: the functional characterization of CNP-2 in Caenorhabditis elegans.
Opposing functions of calcineurin and CaMKII regulate G-protein signaling in egg-laying behavior of C.elegans.
Regulator of calcineurin (rcan-1) regulates thermotaxis behavior in Caenorhabditis elegans.
The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin.
Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.
The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.
Comparative proteomic analysis reveals differentially expressed proteins in Caenorhabditis elegans pgl-1 mutants grown at 20 degrees C and 25 degrees C.
A survey of expressed genes in Caenorhabditis elegans.
Polymerase recognition of synthetic oligodeoxyribonucleotides incorporating degenerate pyrimidine and purine bases.
Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors.
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.
Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.
RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate.
Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants.
C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.
CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans.
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.
Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.
Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
Genetic control of programmed cell death in the nematode C. elegans.
Mechanistic insights into CED-4-mediated activation of CED-3.
Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.
Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.
Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.
The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism.
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons.
The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.
Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene.
C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons.
Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.
The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans.
An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2.
Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.
High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.
Positive cooperativity of the p97 AAA ATPase is critical for essential functions.
Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.
Intermediate filaments are required for C. elegans epidermal elongation.
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans.
Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells.
Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans.
Heterochronic mutants of the nematode Caenorhabditis elegans.
Identification of heterochronic mutants in Caenorhabditis elegans. Temporal misexpression of a collagen::green fluorescent protein fusion gene.
Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans.
Reversal of cell fate determination in Caenorhabditis elegans vulval development.
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.
The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes.
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter.
Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation.
daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans.
A conserved nuclear cyclophilin is required for both RNA polymerase II elongation and co-transcriptional splicing in Caenorhabditis elegans.
Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans.
Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.
miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans.
Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.
Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability.
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.
The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development.
hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1.
Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.
Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9.
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins.
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.
Supplementary nuclear receptor NHR-60 is required for normal embryonic and early larval development of Caenorhabditis elegans.
A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans.
Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis.
Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta subunit.
Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.
Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion.
Tyrosine aminotransferase is involved in the oxidative stress response by metabolizing meta-tyrosine in Caenorhabditis elegans.
Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein lin-10.
CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans.
A novel calmodulin-like gene from the nematode Caenorhabditis elegans.
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving ras and the identification and characterization of evolutionarily conserved domains.
Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates.
Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans.
The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans.
lin-25, a gene required for vulval induction in Caenorhabditis elegans.
Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.
Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans.
A photoconvertible reporter of the ubiquitin-proteasome system in vivo.
Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.
A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans.
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.
CDC-42 controls early cell polarity and spindle orientation in C. elegans.
PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans.
PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos.
Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism.
Molecular cloning of a cDNA for the glutamate transporter of the nematode Caenorhabditis elegans.
WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.
EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.
Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions.
Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue.
The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression.
CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans.
Dual enzymatic properties of the cytoplasmic peptide: N-glycanase in C. elegans.
PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase.
Unique peptide:N-glycanase of Caenorhabditis elegans has activity of protein disulphide reductase as well as of deglycosylation.
Caenorhabditis elegans glutamylating enzymes function redundantly in male mating.
Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans.
Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx.
First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6.
Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans.
Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway.
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans.
Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans.
The genetics of caloric restriction in Caenorhabditis elegans.
eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx.
Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.
Repression of a potassium channel by nuclear hormone receptor and TGF-beta signaling modulates insulin signaling in Caenorhabditis elegans.
The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.
Identification of epi-1 locus as a laminin alpha chain gene in the nematode Caenorhabditis elegans and characterization of epi-1 mutant alleles.
Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.
The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase.
Sex-specific pruning of neuronal synapses in Caenorhabditis elegans.
The Doublesex/Mab-3 domain transcription factor DMD-10 regulates ASH-dependent behavioral responses.
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.
Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity.
unc-53 controls longitudinal migration in C. elegans.
Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.
A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans.
Axon regeneration is regulated by Ets-C/EBP transcription complexes generated by activation of the cAMP/Ca2+ signaling pathways.
Methylmercury Induces Metabolic Alterations in Caenorhabditis elegans: Role for C/EBP Transcription Factor.
Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway.
The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans.
Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.
Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.
Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket.
nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.
The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature.
Lysine methylation of VCP by a member of a novel human protein methyltransferase family.
Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution.
Regulation of lipoprotein assembly, secretion and fatty acid beta-oxidation by Krueppel-like transcription factor, klf-3.
Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis elegans.
C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1.
FGT-1 is a mammalian GLUT2-like facilitative glucose transporter in Caenorhabditis elegans whose malfunction induces fat accumulation in intestinal cells.
Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.
MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans.
The mup-4 locus in Caenorhabditis elegans is essential for hypodermal integrity, organismal morphogenesis and embryonic body wall muscle position.
CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.
Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.
Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans.
Caenorhabditis elegans contains a third polo-like kinase gene.
Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homolog pairing.
Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons.
Identification of genes expressed in C. elegans touch receptor neurons.
Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.
The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans.
The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
Ribosome 18S m6A methyltransferase METTL5 promotes translation initiation and breast cancer cell growth.
A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure.
A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans.
Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans.
DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11.
Dissecting the signaling mechanisms underlying recognition and preference of food odors.
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans.
The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans.
BBLN-1 is essential for intermediate filament organization and apical membrane morphology.
Autophagy-mediated longevity is modulated by lipoprotein biogenesis.
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1.
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase.
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.
CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.
Loss and gain of domains during evolution of cut superclass homeobox genes.
Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth.
LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins.
Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans.
Maturation of the major ubiquitin gene transcript in Caenorhabditis elegans involves the acquisition of a trans-spliced leader.
UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual structural features and is constitutively expressed.
ADBP-1 regulates an ADAR RNA-editing enzyme to antagonize RNA-interference-mediated gene silencing in Caenorhabditis elegans.
Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes.
C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression.
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.
Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A.
The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.
Cell cycle control by daf-21/Hsp90 at the first meiotic prophase/metaphase boundary during oogenesis in Caenorhabditis elegans.
Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis.
The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation.
A global profile of germline gene expression in C. elegans.
The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo.
Architecture of the mitochondrial calcium uniporter.
C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair.
Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.
The role of mitochondria in the life of the nematode, Caenorhabditis elegans.
Structure of sperm-specific protein SSP-19 from Caenorhabditis elegans.
Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.
Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.
MEL-47, a novel protein required for early cell divisions in the nematode Caenorhabditis elegans.
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans.
Caenorhabditis elegans atx-2 promotes germline proliferation and the oocyte fate.
Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation.
EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis elegans.
Genetic regulation of entry into meiosis in Caenorhabditis elegans.
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline.
The GLD-2 poly(A) polymerase activates gld-1 mRNA in the Caenorhabditis elegans germ line.
Tissue-specific modification of gld-2 mRNA in C. elegans: likely C-to-U editing.
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis.
Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.
The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.
A sperm-supplied factor required for embryogenesis in C. elegans.
Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed.
The C. elegans TPR containing protein, TRD-1, regulates cell fate choice in the developing germ line and epidermis.
ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System.
Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons.
C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway.
The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.
Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.
The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.
Abl kinase inhibits the engulfment of apopotic cells in Caenorhabditis elegans.
Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Phagocytosis promotes programmed cell death in C. elegans.
Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.
The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan.
Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.
Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.
Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.
Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans.
Restriction of cellular plasticity of differentiated cells mediated by chromatin modifiers, transcription factors and protein kinases.
The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.
The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism.
Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.
Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.
Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.
Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.
Genes required for osmoregulation and apical secretion in Caenorhabditis elegans.
A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans.
C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites.
par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans.
Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of CRMP and dihydropyrimidinase?
The Ulip family phosphoproteins -- common and specific properties.
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.
C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli.
C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior.
Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine.
Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans.
Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans.
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.
Maze exploration and learning in C. elegans.
Molecular mechanisms of amphetamine actions in Caenorhabditis elegans.
Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene.
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity.
Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans.
The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans.
A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.
Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.
The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.
The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans.
Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans.
C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.
The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans.
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.
LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos.
The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.
The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.
A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological function and expression pattern.
Cloning and characterization of a Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide.
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.
Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.
The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.
The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.
Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.
Titin/connectin-related proteins in C. elegans: a review and new findings.
Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.
Axon regeneration requires a conserved MAP kinase pathway.
C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1.
Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.
Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.
Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.
C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.
Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen.
Direct and heterologous approaches to identify the LET-756/FGF interactome.
Interpreting a sequenced genome: toward a cosmid transgenic library of Caenorhabditis elegans.
Of worms and men: an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families.
The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.
Identification, sequence and expression patterns of the Caenorhabditis elegans col-36 and col-40 collagen-encoding genes.
Isolation of the gene coding for Caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein.
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span.
Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.
DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.
Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells.
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.
The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons.
C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.
C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains.
MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.
MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin.
Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans.
Odorant-selective genes and neurons mediate olfaction in C. elegans.
Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis.
Characterization of PUD-1 and PUD-2, two proteins up-regulated in a long-lived daf-2 mutant.
Developmental defects of Caenorhabditis elegans lacking branched-chain alpha-ketoacid dehydrogenase are mainly caused by monomethyl branched-chain fatty acid deficiency.
A link between meiotic prophase progression and crossover control.
Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast.
Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans.
Mutant rec-1 eliminates the meiotic pattern of crossing over in Caenorhabditis elegans.
Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.
C elegans: a model for exploring the genetics of fat storage.
Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.
Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1.
Lipid metabolic sensors of MDT-15 and SBP-1 regulated the response to simulated microgravity in the intestine of Caenorhabditis elegans.
Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.
Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism.
Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans.
The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease.
Caenorhabditis elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock.
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.
E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.
HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans.
HSF-1 is a regulator of miRNA expression in Caenorhabditis elegans.
HSF-1 is involved in regulation of ascaroside pheromone biosynthesis by heat stress in Caenorhabditis elegans.
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.
Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones in C. elegans.
The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans.
The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.
Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction.
Caenorhabditis elegans calnexin is N-glycosylated and required for stress response.
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum.
A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.
Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains.
Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation.
PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo.
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans.
Repression of gene expression in the embryonic germ lineage of C. elegans.
The PIE-1 protein and germline specification in C. elegans embryos.
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.
An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans.
Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker.
Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues.
PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors.
A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm.
C. elegans Runx/CBFbeta suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells.
Establishment of POP-1 asymmetry in early C. elegans embryos.
POP-1 controls axis formation during early gonadogenesis in C. elegans.
The tumor suppressor BCL7B functions in the Wnt signaling pathway.
pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos.
Existence of four acetylcholinesterase genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
An RNA 5'-triphosphatase related to the protein tyrosine phosphatases.
Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis.
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system.
UNC119 is required for G protein trafficking in sensory neurons.
A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis.
ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans.
Caenorhabditis elegans receptors related to mammalian vascular endothelial growth factor receptors are expressed in neural cells.
The family of Caenorhabditis elegans tyrosine kinase receptors: similarities and differences with mammalian receptors.
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.
Solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP).
The Caenorhabditis elegans protein CTBP-1 defines a new group of THAP domain-containing CtBP corepressors.
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2.
MAPK-15 is a ciliary protein required for PKD-2 localization and male mating behavior in Caenorhabditis elegans.
Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.
The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans.
SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.
Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.
Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.
N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans.
The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development.
The Caenorhabditis elegans Ldb/NLI/Clim orthologue ldb-1 is required for neuronal function.
NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane.
A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi.
MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans.
Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance.
The ced-8 gene controls the timing of programmed cell deaths in C. elegans.
Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.
TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.
Three vha genes encode proteolipids of Caenorhabditis elegans vacuolar-type ATPase. Gene structures and preferential expression in an H-shaped excretory cell and rectal cells.
A fasting-responsive signaling pathway that extends life span in C. elegans.
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan.
GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5.
Global functional analyses of cellular responses to pore-forming toxins.
A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans.
HLH-14 is a C. elegans achaete-scute protein that promotes neurogenesis through asymmetric cell division.
Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis.
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis.
Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C. elegans.
Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1.
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.
LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.
Effective RNA interference in cultured silkworm cells mediated by overexpression of Caenorhabditis elegans SID-1.
Enhanced neuronal RNAi in C. elegans using SID-1.
Export of RNA silencing from C. elegans tissues does not require the RNA channel SID-1.
Genes required for systemic RNA interference in Caenorhabditis elegans.
SID-1 is a dsRNA-selective dsRNA-gated channel.
SID-1 protein of Caenorhabditis elegans mediates uptake of dsRNA into Bombyx cells.
Systemic RNA interference deficiency-1 (SID-1) extracellular domain selectively binds long double-stranded RNA and is required for RNA transport by SID-1.
Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.
Systemic RNAi in Caenorhabditis elegans.
The SID-1 double-stranded RNA transporter is not selective for dsRNA length.
Transport of dsRNA into cells by the transmembrane protein SID-1.
Uptake of extracellular double-stranded RNA by SID-2.
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.
RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development.
Regulation of rnt-1 expression mediated by the opposing effects of BRO-1 and DBL-1 in the nematode Caenorhabditis elegans.
Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.
The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal.
The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell.
cDNA cloning of run, a Caenorhabditis elegans Runt domain encoding gene.
mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage.
mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing.
Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode.
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity.
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.
Control of rapsyn stability by the CUL-3-containing E3 ligase complex.
Conserved initiator proteins in eukaryotes.
Genetic and molecular characterization of the Caenorhabditis elegans spermatogenesis-defective gene spe-17.
A C-terminal targeting signal controls differential compartmentalisation of Caenorhabditis elegans host cell factor (HCF) to the nucleus or mitochondria.
Developmental and cell-cycle regulation of Caenorhabditis elegans HCF phosphorylation.
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans.
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.
Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3.
Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation.
The EGR family gene egrh-1 functions non-autonomously in the control of oocyte meiotic maturation and ovulation in C. elegans.
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
The lactate dehydrogenase gene from nematode Caenorhabditis elegans contains only two of six introns conserved in the protein-encoding sequence of LDH genes from bird and mammals.
The nucleotide and deduced amino-acid sequences of a cDNA encoding lactate dehydrogenase from Caenorhabditis elegans: the evolutionary relationships of lactate dehydrogenases from mammals, birds, amphibian, fish, nematode, plants, bacteria, mycoplasma, and plasmodium.
Essential kinase-independent role of a Fer-like non-receptor tyrosine kinase in Caenorhabditis elegans morphogenesis.
Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.
ARK-1 inhibits EGFR signaling in C. elegans.
The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.
A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans.
High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis.
Molecular evolution and quantitative variation for chemosensory behaviour in the nematode genus Caenorhabditis.
Proteins interacting with Caenorhabditis elegans Galpha subunits.
The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons.
Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans.
The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron.
SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans.
Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination.
Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans.
The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.
Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development.
Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis.
The Caenorhabditis elegans spe-5 gene is required for morphogenesis of a sperm-specific organelle and is associated with an inherent cold-sensitive phenotype.
MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in Caenorhabditis elegans.
MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.
MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans.
MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.
MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans.
The chromodomain protein MRG-1 facilitates SC-independent homologous pairing during meiosis in Caenorhabditis elegans.
The contactin RIG-6 mediates neuronal and non-neuronal cell migration in Caenorhabditis elegans.
A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division.
Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.
Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans.
Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.
Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1.
Genes necessary for C. elegans cell and growth cone migrations.
Identification of Caenorhabditis elegans genes required for neuronal differentiation and migration.
Isolation and characterization of high-temperature-induced Dauer formation mutants in Caenorhabditis elegans.
The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway.
The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration.
Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans.
The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans.
Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans.
Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth.
clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.
Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes.
Genetic and molecular analysis of spe-27, a gene required for spermiogenesis in Caenorhabditis elegans hermaphrodites.
Solution structure and dynamics of glia maturation factor from Caenorhabditis elegans.
Myrf ER-bound transcription factors drive C. elegans synaptic plasticity via cleavage-dependent nuclear translocation.
Regulation of the C. elegans molt by pqn-47.
The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.
A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans.
A transcription factor controlling development of peripheral sense organs in C. elegans.
ANK repeat-domain of SHN-1 is indispensable for in vivo SHN-1 function in C. elegans.
Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans.
Dissection of the promoter region of the inositol 1,4,5-trisphosphate receptor gene, itr-1, in C. elegans: a molecular basis for cell-specific expression of IP3R isoforms.
Eph and NMDA receptors control Ca2+/calmodulin-dependent protein kinase II activation during C. elegans oocyte meiotic maturation.
IRI-1, a LIN-15B homologue, interacts with inositol-1,4,5-triphosphate receptors and regulates gonadogenesis, defecation, and pharyngeal pumping in Caenorhabditis elegans.
Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1).
Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.
Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans.
Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma.
Regulated disruption of inositol 1,4,5-trisphosphate signaling in Caenorhabditis elegans reveals new functions in feeding and embryogenesis.
SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor.
The inositol 1,4,5-trisphosphate receptor regulates epidermal cell migration in Caenorhabditis elegans.
The inositol trisphosphate receptor regulates a 50-second behavioral rhythm in C. elegans.
Identification and characterization of the vesicular GABA transporter.
C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.
Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.
C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.
Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.
PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development.
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN.
Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway.
The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.
A neuronal signaling pathway of CaMKII and Gqalpha regulates experience-dependent transcription of tph-1.
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments.
D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons.
Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM kinase II.
Food deprivation attenuates seizures through CaMKII and EAG K+ channels.
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program.
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans.
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II.
Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction.
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.
The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates.
The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males.
The role of regulatory domain interactions in UNC-43 CaMKII localization and trafficking.
Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.
Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans.
Asymmetric arginine dimethylation modulates mitochondrial energy metabolism and homeostasis in Caenorhabditis elegans.
Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.
Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.
Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression.
Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans.
Discovery of a cholecystokinin-gastrin-like signaling system in nematodes.
Embryonic lethality caused by mutations in basement membrane collagen of C. elegans.
Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons.
The two Caenorhabditis elegans basement membrane (type IV) collagen genes are located on separate chromosomes.
Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids.
Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways.
Cyclin D involvement demarcates a late transition in C. elegans embryogenesis.
Cyclin D regulation of a sexually dimorphic asymmetric cell division.
Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex.
A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.
The Caenorhabditis elegans homolog of FGD1, the human Cdc42 GEF gene responsible for faciogenital dysplasia, is critical for excretory cell morphogenesis.
Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor.
Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.
The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans.
Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans.
The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51.
An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.
UAP56 levels affect viability and mRNA export in Caenorhabditis elegans.
Active transport and diffusion barriers restrict Joubert syndrome-associated ARL13B/ARL-13 to an inv-like ciliary membrane subdomain.
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans.
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.
Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival.
The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans.
A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans.
Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans.
A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.
Pseudocleavage is dispensable for polarity and development in C. elegans embryos.
RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4.
Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR exposure in nematode Caenorhabditis elegans.
The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily.
The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegans.
The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans.
The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans.
odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl.
SAS-4 is a C. elegans centriolar protein that controls centrosome size.
SAS-4 is essential for centrosome duplication in C. elegans and is recruited to daughter centrioles once per cell cycle.
Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.
Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans.
Tripeptidyl peptidase II promotes fat formation in a conserved fashion.
Cloning and characterization of the C. elegans histidyl-tRNA synthetase gene.
Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome.
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
Alternative splicing of gar-1, a Caenorhabditis elegans G-protein-linked acetylcholine receptor gene.
Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans.
Cloning and expression of a G protein-linked acetylcholine receptor from Caenorhabditis elegans.
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.
Protection of C. elegans from anoxia by HYL-2 ceramide synthase.
Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans.
Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants.
The C. elegans Frizzled CFZ-2 is required for cell migration and interacts with multiple Wnt signaling pathways.
CFL-1, a novel F-box protein with leucine-rich repeat may interact with UNC-10 for the regulation of defecation and daumone response in Caenorhabditis elegans.
Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination.
The Caenorhabditis elegans RAD51 homolog is transcribed into two alternative mRNAs potentially encoding proteins of different sizes.
Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability.
Characterization of metallothionein cDNAs induced by cadmium in the nematode Caenorhabditis elegans.
Metallothionein genes in the nematode Caenorhabditis elegans and metal inducibility in mammalian culture cells.
Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans.
The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression.
The C. elegans vitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes.
The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein.
Vitellogenin motifs conserved in nematodes and vertebrates.
Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans.
Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin.
Neurosecretory control of aging in Caenorhabditis elegans.
The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin.
The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.
A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.
Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.
Radiation-sensitive mutants of Caenorhabditis elegans.
The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans.
The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.
Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing.
Essential role of brc-2 in chromosome integrity of germ cells in C. elegans.
Paradoxical delay of senescence upon depletion of BRCA2 in telomerase-deficient worms.
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.
Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2.
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.
Collaboration within the M1 aminopeptidase family promotes reproductive success in Caenorhabditis elegans.
Sustained centrosome-cortical contact ensures robust polarization of the one-cell C. elegans embryo.
The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction.
The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo.
A yeast two-hybrid screen for SYP-3 interactors identifies SYP-4, a component required for synaptonemal complex assembly and chiasma formation in Caenorhabditis elegans meiosis.
Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans.
Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.
G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.
The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans.
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
A forkhead protein controls sexual identity of the C. elegans male somatic gonad.
RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing.
An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.
Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans.
A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons.
Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans.
Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans.
Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.
The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway.
Unique and redundant beta-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division.
mig-5/Dsh controls cell fate determination and cell migration in C. elegans.
The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.
A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells.
Two paralogous tetraspanins TSP-12 and TSP-14 function with the ADAM10 metalloprotease SUP-17 to promote BMP signaling in caenorhabditis elegans.
Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males.
A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction.
Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes.
Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.
The axial element protein HTP-3 promotes cohesin loading and meiotic axis assembly in C. elegans to implement the meiotic program of chromosome segregation.
Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display.
egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans.
A divergent multi-domain cyclophilin is highly conserved between parasitic and free-living nematode species and is important in larval muscle development.
More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans.
A glial K/Cl transporter controls neuronal receptive ending shape by chloride inhibition of an rGC.
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.
Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans.
Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
Two wnt genes in Caenorhabditis elegans.
SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network.
Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade.
EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans.
G alphas-induced neurodegeneration in Caenorhabditis elegans.
Mutations of the caenorhabditis elegans brain-specific inorganic phosphate transporter eat-4 affect habituation of the tap-withdrawal response without affecting the response itself.
Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channels.
Caenorhabditis elegans ivermectin receptors regulate locomotor behaviour and are functional orthologues of Haemonchus contortus receptors.
Principles of activation and permeation in an anion-selective Cys-loop receptor.
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
TMCO1 is an ER Ca(2+) load-activated Ca(2+) channel.
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.
GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans.
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.
A secreted complement control-related protein ensures acetylcholine receptor clustering.
Proteolytic processing of the extracellular scaffolding protein LEV-9 is required for clustering acetylcholine receptors.
A nuclear lamin protein of the nematode Caenorhabditis elegans with unusual structural features: cDNA cloning and gene organization.
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes.
Fate of the nuclear lamina during Caenorhabditis elegans apoptosis.
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.
The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration.
Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.
Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.
cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans.
A stress-responsive system for mitochondrial protein degradation.
Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.
Strong selective pressure to use G:U to mark an RNA acceptor stem for alanine.
LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis.
The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans.
Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.
Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site.
Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans.
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.
The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.
Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl).
Conservation of the centromere/kinetochore protein ZW10.
Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.
A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans.
LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans.
Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans.
Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing.
Caenorhabditis elegans par2.1/mtssb-1 is essential for mitochondrial DNA replication and its defect causes comprehensive transcriptional alterations including a hypoxia response.
Caenorhabditis elegans, a pluricellular model organism to screen new genes involved in mitochondrial genome maintenance.
Local F-actin network links synapse formation and axon branching.
The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans.
NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome.
Characterisation of set-1, a conserved PR/SET domain gene in Caenorhabditis elegans.
Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.
Chondroitin 4-O-sulfotransferase ss indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes.
Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans.
Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans.
Dopamine negatively modulates the NCA ion channels in C. elegans.
G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.
Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.
A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans.
DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells.
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.
Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction.
Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras.
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein.
Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.
Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans.
Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.
spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.
Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain.
Local microtubule organization promotes cargo transport in C. elegans dendrites.
Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.
UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration.
DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.
Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans.
tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans.
The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.
PLP-1 binds nematode double-stranded telomeric DNA.
Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans.
Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans.
Experience-dependent modulation of C. elegans behavior by ambient oxygen.
A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans.
An endocytic pathway as a target of tubby for regulation of fat storage.
C. elegans tubby regulates life span and fat storage by two independent mechanisms.
Genetic and molecular analysis of a Caenorhabditis elegans beta-tubulin that conveys benzimidazole sensitivity.
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.
Polygenic control of Caenorhabditis elegans fat storage.
A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene.
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.
Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans.
Transcriptional control of non-apoptotic developmental cell death in C. elegans.
Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Delta6 Desaturase (fat-3) and Generates New omega-3 Endocannabinoids.
Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans.
The RDE-10/RDE-11 complex triggers RNAi-induced mRNA degradation by association with target mRNA in C. elegans.
Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans.
The C. elegans gene pme-5: molecular cloning and role in the DNA-damage response of a tankyrase orthologue.
The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes.
Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior.
Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development.
Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.
Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.
Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans.
A molecular evolutionary framework for eukaryotic model organisms.
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans.
Caenorhabditis elegans cDNA for a Menkes/Wilson disease gene homologue and its function in a yeast CCC2 gene deletion mutant.
A gene required for nuclear and mitochondrial attachment in the nematode Caenorhabditis elegans.
A genetic approach to study the role of nuclear envelope components in nuclear positioning.
Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans.
Role of ANC-1 in tethering nuclei to the actin cytoskeleton.
The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.
UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.
Cyclophilin and protein disulfide isomerase genes are co-transcribed in a functionally related manner in Caenorhabditis elegans.
Identification and characterization of a new member of the gas3/PMP22 gene family in C. elegans.
Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60.
Coordination of cell proliferation and cell fate determination by CES-1 snail.
A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses.
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.
Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.
The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.
ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development.
Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans.
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.
omega-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein with four gelsolin-like repeats.
Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in actin filament severing, barbed end capping, and phosphoinositide binding.
TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats.
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans.
Mutants carrying two sma mutations are super small in the nematode C. elegans.
A C. elegans Zona Pellucida domain protein functions via its ZPc domain.
Characterization of the let-653 gene in Caenorhabditis elegans.
Integrity of narrow epithelial tubes in the C. elegans excretory system requires a transient luminal matrix.
Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2.
A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.
Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
Control of neuronal subtype identity by the C. elegans ARID protein CFI-1.
Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1.
The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs.
Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle.
Evidence for evolutionary conservation of sex-determining genes.
C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata.
Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis.
Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene.
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.
Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans.
The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'.
A post-docking role for active zone protein Rim.
Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans.
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.
The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.
Centrosome-associated degradation limits beta-catenin inheritance by daughter cells after asymmetric division.
An autosomal gene that affects X chromosome expression and sex determination in Caenorhabditis elegans.
Molecular analysis of X chromosome dosage compensation in Caenorhabditis elegans.
PAN-1, a P-granule component important for C. elegans fertility, has dual roles in the germline and soma.
glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingers.
The NEMP family supports metazoan fertility and nuclear envelope stiffness.
The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs.
Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.
PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.
PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.
Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans.
Alternative splicing of the muscarinic acetylcholine receptor GAR-3 in Caenorhabditis elegans.
Cloning and functional characterization of a Caenorhabditis elegans muscarinic acetylcholine receptor.
Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules.
Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage.
Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans.
GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans.
A directed RNAi screen based on larval growth arrest reveals new modifiers of C. elegans insulin signaling.
FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways.
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.
The RNase PARN-1 trims piRNA 3' ends to promote transcriptome surveillance in C. elegans.
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans.
The Caenorhabditis elegans UNC-87 protein is essential for maintenance, but not assembly, of bodywall muscle.
The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.
UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.
A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis.
Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans.
Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14.
Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans.
Mitotic CDK Promotes replisome disassembly, fork breakage, and complex DNA rearrangements.
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication.
A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.
Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability.
Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans.
Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans.
HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
Casein kinase II from Caenorhabditis elegans. Properties and developmental regulation of the enzyme; cloning and sequence analyses of cDNA and the gene for the catalytic subunit.
Unique structural features of a novel class of small heat shock proteins.
C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.
Polycistronic expression and RNA-binding specificity of the C. elegans homologue of the spliceosome-associated protein SAP49.
Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway.
Analysis of chitin synthase function in a plant parasitic nematode, Meloidogyne artiellia, using RNAi.
Nematode chitin synthases: gene structure, expression and function in Caenorhabditis elegans and the plant parasitic nematode Meloidogyne artiellia.
The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively.
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.
Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans.
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types.
HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development.
C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development.
C. elegans MANF Homolog Is Necessary for the Protection of Dopaminergic Neurons and ER Unfolded Protein Response.
Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.
Expression profiling of MAP kinase-mediated meiotic progression in Caenorhabditis elegans.
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes.
GCNA Preserves Genome Integrity and Fertility Across Species.
SUMOylation promotes protective responses to DNA-protein cross-links.
Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.
Torque generation by one of the motor subunits of heterotrimeric kinesin-2.
Eukaryotic translation initiation factor 5B activity regulates larval growth rate and germline development in Caenorhabditis elegans.
C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor.
Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans.
Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans.
Deoxyribonuclease II: structure and chromosomal localization of the murine gene, and comparison with the genomic structure of the human and three C. elegans homologs.
The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans.
Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.
Cellular and axonal migrations are misguided along both body axes in the maternal-effect mau-2 mutants of Caenorhabditis elegans.
Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans.
mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans.
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.
Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.
Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans.
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.
ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans.
Isolation of AF2 (KHEYLRFamide) from Caenorhabditis elegans: evidence for the presence of more than one FMRFamide-related peptide-encoding gene.
Alternative splicing leads to two cholinergic proteins in Caenorhabditis elegans.
The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter.
Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.
TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.
The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.
Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.
The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans.
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans.
Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms.
Ribonuclease-mediated control of body fat.
GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans.
The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts.
Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans.
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans.
Novel transcription coactivator complex containing activating signal cointegrator 1.
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.
sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.
cdk-7 is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.
Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.
Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants.
acr-23 encodes a monepantel-sensitive channel in Caenorhabditis elegans.
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.
Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain.
Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.
Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair.
Critical role of Caenorhabditis elegans homologs of cds1 (Chk2)-related kinases in meiotic recombination.
Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression.
C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p.
The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length.
Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons.
The nucleotide sequence of a nematode vitellogenin gene.
KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans.
Worms in space? A model biological dosimeter.
FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans.
Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans.
Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans.
LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function.
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.
A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor.
Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans.
Modification of epidermal growth factor-like repeats with O-fucose: molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
Structural insights into the mechanism of protein O-fucosylation.
UNC-1 regulates gap junctions important to locomotion in C. elegans.
A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans.
Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.
Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans.
Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels.
Functional analysis of leucine aminopeptidase in Caenorhabditis elegans.
Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
Expression in yeast of an acyl-CoA:diacylglycerol acyltransferase cDNA from Caenorhabditis elegans.
Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance.
Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans.
NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans.
Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.
The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans.
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans.
Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades.
UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.
Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo.
IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.
Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.
The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast.
A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans.
A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans.
Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity.
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.
Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling.
The influence of bacterial diet on fat storage in C. elegans.
Genomic structure and 5' regulatory regions of the let-23 gene in the nematode C. elegans.
Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.
Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function.
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily.
The function of a spindle checkpoint gene bub-1 in C. elegans development.
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.
Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans.
A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans.
Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans.
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
Membrane localization of the NlpC/P60 family protein EGL-26 correlates with regulation of vulval cell morphogenesis in Caenorhabditis elegans.
The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis.
Centriole assembly requires both centriolar and pericentriolar material proteins.
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells.
Structural basis of the 9-fold symmetry of centrioles.
Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1.
Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.
Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues.
The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis.
The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans.
sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans.
Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans.
Identification of a Caenorhabditis elegans histone H1 gene family. Characterization of a family member containing an intron and encoding a poly(A)+ mRNA.
Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
The primary structure of the major isoform (H1.1) of histone H1 from the nematode Caenorhabditis elegans.
Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.
Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.
The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans.
A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis.
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development.
Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans.
DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.
Human DJ-1 and its homologs are novel glyoxalases.
BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development.
BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans.
Basolateral endocytic recycling requires RAB-10 and AMPH-1 mediated recruitment of RAB-5 GAP TBC-2 to endosomes.
EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans.
RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine.
RAB-10 regulates dendritic branching by balancing dendritic transport.
RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway.
RAB-10-dependent membrane transport is required for dendrite arborization.
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans.
SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans.
Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia.
Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor.
NPR-9, a galanin-like G-protein coupled receptor, and GLR-1 regulate interneuronal circuitry underlying multisensory integration of environmental cues in Caenorhabditis elegans.
SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans.
Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans.
Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform.
GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions.
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation.
unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.
Cuticle Integrity and Biogenic Amine Synthesis in Caenorhabditis elegans Require the Cofactor Tetrahydrobiopterin (BH4).
Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.
Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.
PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.
The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.
The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.
Mutation in Caenorhabditis elegans Krueppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition.
Actomyosin tube formation in polar body cytokinesis requires Anillin in C. elegans.
Anillin promotes astral microtubule-directed cortical myosin polarization.
Caenorhabditis elegans anillin (ani-1) regulates neuroblast cytokinesis and epidermal morphogenesis during embryonic development.
An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells.
C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle.
Interaction between a putative mechanosensory membrane channel and a collagen.
Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.
Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle.
The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.
The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex.
XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision.
xol-1: a gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans.
The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans.
Pore architecture of TRIC channels and insights into their gating mechanism.
A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans.
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans.
Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans.
Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans.
Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation.
C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair.
The Caenorhabditis elegans hsp70 gene family: a molecular genetic characterization.
APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.
APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.
Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans.
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function.
Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site.
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.
apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.
feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping.
Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC.
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.
A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.
cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans.
ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans.
Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad.
Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegans.
Rapid expression screening of Caenorhabditis elegans homeobox open reading frames using a two-step polymerase chain reaction promoter-gfp reporter construction technique.
A mutational analysis of Caenorhabditis elegans in space.
Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.
Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.
Insights into autoregulation from the crystal structure of twitchin kinase.
Mutants with altered muscle structure of Caenorhabditis elegans.
Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.
Computational and molecular characterization of multiple isoforms of lfe-2 gene in nematode C. elegans.
Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly.
emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation.
A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm.
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
Caenorhabditis elegans SID-2 is required for environmental RNA interference.
Tetrameric assembly of K(+) channels requires ER-located chaperone proteins.
SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos.
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.
Structural genomics of Caenorhabditis elegans: structure of the BAG domain.
Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte.
Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway.
Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae.
mua-6, a gene required for tissue integrity in Caenorhabditis elegans, encodes a cytoplasmic intermediate filament.
Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans.
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.
LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos.
MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells.
The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo.
APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity.
Isolation and preliminary biological assessment of AADGAPLIRFamide and SVPGVLRFamide from Caenorhabditis elegans.
Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules.
Mos1-mediated transgenesis to probe consequences of single gene mutations in variation-rich isolates of Caenorhabditis elegans.
TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos.
TAC-1, a regulator of microtubule length in the C. elegans embryo.
ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.
Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism.
REST and stress resistance in ageing and Alzheimer's disease.
Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression.
An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site.
Angiotensin converting enzyme (ACE) inhibitor extends Caenorhabditis elegans life span.
Molecular and biochemical characterization of S-adenosylmethionine decarboxylase from the free-living nematode Caenorhabditis elegans.
Presynaptic UNC-31 (CAPS) is required to activate the G(alpha)s pathway of the Caenorhabditis elegans synaptic signaling network.
The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions.
An essential ubiquitin-conjugating enzyme with tissue and developmental specificity in the nematode Caenorhabditis elegans.
The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation.
C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity.
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans.
Opposing Wnt pathways orient cell polarity during organogenesis.
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously.
The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions.
The roles of EGF and Wnt signaling during patterning of the C. elegans Bgamma/delta Equivalence Group.
Wnt gradient formation requires retromer function in Wnt-producing cells.
Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegans.
Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans.
Wnt signals can function as positional cues in establishing cell polarity.
The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye.
Genetic suppressors of Caenorhabditis elegans pha-4/FoxA identify the predicted AAA helicase ruvb-1/RuvB.
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
A deubiquitinating enzyme, UCH/CeUBP130, has an essential role in the formation of a functional microtubule-organizing centre (MTOC) during early cleavage in C. elegans.
A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo.
Structural genomics of Caenorhabditis elegans: structure of dihydropteridine reductase.
Behavioral defects in C. elegans egl-36 mutants result from potassium channels shifted in voltage-dependence of activation.
EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity.
An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor.
Interaction and regulation of subcellular localization of CED-4 by CED-9.
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.
Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.
Identification of a heat-shock pseudogene from Caenorhabditis elegans.
A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).
Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans.
Early aspects of Caenorhabditis elegans sex determination and dosage compensation are regulated by a zinc-finger protein.
Fndc-1 contributes to paternal mitochondria elimination in C. elegans.
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene.
Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans.
Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans.
Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.
Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans.
LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae.
Backbone 1H, 15N and 13C assignments for the 21 kDa Caenorhabditis elegans homologue of 'brain-specific' protein.
The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission.
Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans.
Mutants of a temperature-sensitive two-P domain potassium channel.
MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana.
SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.
Paramyosin gene (unc-15) of Caenorhabditis elegans. Molecular cloning, nucleotide sequence and models for thick filament structure.
Phosphorylation of the N-terminal region of Caenorhabditis elegans paramyosin.
Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.
Sensory perception of food and insulin-like signals influence seizure susceptibility.
zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly.
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.
ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals.
Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits.
C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis.
lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.
Perilipin-related protein regulates lipid metabolism in C. elegans.
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine].
Human skeletal muscle nebulin sequence encodes a blueprint for thin filament architecture. Sequence motifs and affinity profiles of tandem repeats and terminal SH3.
CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells.
The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression.
gon-2, a gene required for gonadogenesis in Caenorhabditis elegans.
Cloning and characterization of a Caenorhabditis elegans D2-like dopamine receptor.
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.
Expression and phenotype analysis of the nephrocystin-1 and nephrocystin-4 homologs in Caenorhabditis elegans.
Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans.
The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis.
NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.
Human alpha- and beta-NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin-deficient mutants.
Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates.
The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3' untranslated region in Caenorhabditis elegans.
Identification and characterization of the high-affinity choline transporter.
Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.
Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cord.
Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.
The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans.
Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping.
Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors.
Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain.
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.
CEH-28 activates dbl-1 expression and TGF-beta signaling in the C. elegans M4 neuron.
Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling.
DBL-1, a TGF-beta, is essential for Caenorhabditis elegans aversive olfactory learning.
Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans.
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis.
Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission.
C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.
Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans.
Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans.
SID-5 is an endosome-associated protein required for efficient systemic RNAi in C. elegans.
A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans.
An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.
Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor.
Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo.
ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.
GATA transcription factor required for immunity to bacterial and fungal pathogens.
Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification.
Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans.
Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans.
Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1).
Phylum-level conservation of regulatory information in nematodes despite extensive non-coding sequence divergence.
Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2.
Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.
TOR signaling couples oxygen sensing to lifespan in C. elegans.
The DM domain transcription factor MAB-3 regulates male hypersensitivity to oxidative stress in Caenorhabditis elegans.
The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine.
The developmental intestinal regulator ELT-2 controls p38-dependent immune responses in adult C. elegans.
Variability in gene expression underlies incomplete penetrance.
elt-2, a second GATA factor from the nematode Caenorhabditis elegans.
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.
DAF-12 regulates a connected network of genes to ensure robust developmental decisions.
Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.
Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain.
Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.
Structure and expression of daf-12: a nuclear hormone receptor with three isoforms that are involved in development and aging in Caenorhabditis elegans.
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.
DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age.
The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans.
UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.
Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.
The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis.
RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans.
Computer simulations and image processing reveal length-dependent pulling force as the primary mechanism for C. elegans male pronuclear migration.
Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding.
Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis.
Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos.
Lifespan shortening of the nematode Caenorhabditis elegans under higher concentrations of oxygen.
Mutations affecting the meiotic and mitotic divisions of the early Caenorhabditis elegans embryo.
Parental effects and phenotypic characterization of mutations that affect early development in Caenorhabditis elegans.
The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent.
Two loci required for cytoplasmic organization in early embryos of Caenorhabditis elegans.
ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meiotic and mitotic spindle poles.
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.
Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans.
Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans.
An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.
Molecular cloning and sequencing of ama-1, the gene encoding the largest subunit of Caenorhabditis elegans RNA polymerase II.
Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline.
Transcription reactivation steps stimulated by oocyte maturation in C. elegans.
The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.
ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans.
Cloning and characterization of cDNAs encoding putative glutamate transporters from Caenorhabditis elegans and Onchocerca volvulus.
Structure and activity of a new form of the glutamate transporter of the nematode Caenorhabditis elegans.
Evolutionary conservation of a GPCR-independent mechanism of trimeric G protein activation.
cDNA sequence, gene structure, and in vitro expression of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans.
The gene lin-3 encodes an inductive signal for vulval development in C. elegans.
Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei.
Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane.
The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture.
The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote.
UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84.
toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.
unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration.
Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.
mab-7 encodes a novel transmembrane protein that orchestrates sensory ray morphogenesis in C. elegans.
Characterization of a promiscuous GTPase-activating protein that has a bcr-related domain from Caenorhabditis elegans.
Polarization of the C. elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts.
Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans.
The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification.
Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene.
Dcp2 Decaps m2,2,7GpppN-capped RNAs, and its activity is sequence and context dependent.
Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans.
Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway.
The C. elegans mRNA decapping enzyme shapes morphology of cilia.
The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development.
The DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans.
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
The bHLH-PAS gene hlh-34 is expressed in the AVH, not AVJ interneurons.
The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion.
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan.
Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
cec-1, a soma-specific chromobox-containing gene in C. elegans.
Identification of genes involved in the ciliary trafficking of C. elegans PKD-2.
The CIL-1 PI 5-phosphatase localizes TRP polycystins to cilia and activates sperm in C. elegans.
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.
p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans.
Developmental genetic analysis of troponin T mutations in striated and nonstriated muscle cells of Caenorhabditis elegans.
Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3.
Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction.
The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression.
An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans.
A conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cells.
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.
Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans.
Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans.
Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans.
Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans.
Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene.
Mutations in the alpha 2(IV) basement membrane collagen gene of Caenorhabditis elegans produce phenotypes of differing severities.
Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans.
Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes.
A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans.
Deletion of Phytochelatin Synthase Modulates the Metal Accumulation Pattern of Cadmium Exposed C. elegans.
Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans.
Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans.
The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.
The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.
The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.
Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans.
The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans.
Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.
Centriolar SAS-5 is required for centrosome duplication in C. elegans.
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo.
TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans.
The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis.
The TBP-like factor: an alternative transcription factor in metazoa?
The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.
Insulin worms its way into the spotlight.
MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos.
The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen.
RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.
A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis.
MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans.
Maternal control of a zygotic patterning gene in Caenorhabditis elegans.
Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression.
Polycomb group regulation of Hox gene expression in C. elegans.
Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system.
Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans.
Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos.
Specification of the C. elegans MS blastomere by the T-box factor TBX-35.
The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development.
The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo.
The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos.
The myogenic potency of HLH-1 reveals wide-spread developmental plasticity in early C. elegans embryos.
Zygotic expression of the caudal homolog pal-1 is required for posterior patterning in Caenorhabditis elegans embryogenesis.
An evolutionarily conserved gene required for proper microtubule architecture in Caenorhabditis elegans.
Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference.
Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans.
Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.
Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.
ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans.
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.
The stem-loop binding protein CDL-1 is required for chromosome condensation, progression of cell death and morphogenesis in Caenorhabditis elegans.
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.
The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development.
A stomatin-like protein necessary for mechanosensation in C. elegans.
Pseudosynapsis and decreased stringency of meiotic repair pathway choice on the hemizygous sex chromosome of Caenorhabditis elegans males.
Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating.
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.
Direct and positive regulation of Caenorhabditis elegans bed-3 by PRDM1/BLIMP1 ortholog BLMP-1.
MIG-13 positions migrating cells along the anteroposterior body axis of C. elegans.
CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.
The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification.
Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex.
The Caenorhabditis elegans DDX-23, a homolog of yeast splicing factor PRP28, is required for the sperm-oocyte switch and differentiation of various cell types.
The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22.
The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-repressor interaction for uterine muscle specification.
The T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegans.
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.
The POU gene ceh-18 promotes gonadal sheath cell differentiation and function required for meiotic maturation and ovulation in Caenorhabditis elegans.
A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans.
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.
Casein Kinase 1delta Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.
A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage.
Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types.
A genetic pathway for regulation of tra-2 translation.
Conservation of the C.elegans tra-2 3'UTR translational control.
RNA remodeling activity of DEAD box proteins tuned by protein concentration, RNA length, and ATP.
The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase.
The DEAD Box RNA helicase VBH-1 is a new player in the stress response in C. elegans.
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics.
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.
AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.
Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.
Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis.
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.
Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network.
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.
Structural evolution of C-terminal domains in the p53 family.
The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis.
The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway.
Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family.
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.
C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development.
Caenorhabditis elegans histone methyltransferase MET-2 shields the male X chromosome from checkpoint machinery and mediates meiotic sex chromosome inactivation.
Identification of C. elegans sensory ray genes using whole-genome expression profiling.
Profiling of the mammalian mitotic spindle proteome reveals an ER protein, OSTD-1, as being necessary for cell division and ER morphology.
Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox.
A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target.
A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome.
CHR3: a Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting.
Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans.
NHR-23 dependent collagen and hedgehog-related genes required for molting.
Nuclear hormone receptor CHR3 is a critical regulator of all four larval molts of the nematode Caenorhabditis elegans.
The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
A novel calcineurin-interacting protein, CNP-3, modulates calcineurin deficient phenotypes in Caenorhabditis elegans.
Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.
Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans.
The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis.
Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.
Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.
cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans.
Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding.
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.
Characterization of xnp-1, a Caenorhabditis elegans gene similar to the human XNP/ATR-X gene.
A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis.
Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.
The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination.
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
Embryonic tissue differentiation in Caenorhabditis elegans requires dif-1, a gene homologous to mitochondrial solute carriers.
COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans.
EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.
The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.
C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling.
Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway.
A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape.
Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length.
Anterior organization of the Caenorhabditis elegans embryo by the labial-like Hox gene ceh-13.
Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes.
The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans.
Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans.
An "elongated" translation elongation factor Tu for truncated tRNAs in nematode mitochondria.
Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.
C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.
Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase.
A new kind of informational suppression in the nematode Caenorhabditis elegans.
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans.
Behavioral and synaptic defects in C. elegans lacking the NK-2 homeobox gene ceh-28.
Functional analysis of the methylmalonyl-CoA epimerase from Caenorhabditis elegans.
Modulation of dopamine-dependent behaviors by the Caenorhabditis elegans Olig homolog HLH-17.
Molecular characterization of HLH-17, a C. elegans bHLH protein required for normal larval development.
Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2.
Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog.
jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans.
Caenorhabditis elegans sex-determining protein FEM-2 is a protein phosphatase that promotes male development and interacts directly with FEM-3.
The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase.
The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis.
Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans.
Chaperone-interacting TPR proteins in Caenorhabditis elegans.
Genomic organization, expression, and analysis of the troponin C gene pat-10 of Caenorhabditis elegans.
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
Antioxidant enzymes and their role in phoxim and carbaryl stress in Caenorhabditis elegans.
Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans.
Metabotyping of Caenorhabditis elegans reveals latent phenotypes.
Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans.
A conserved family of proteins facilitates nascent lipid droplet budding from the ER.
end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos.
Cation diffusion facilitator proteins modulate Raf-1 activity.
Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.
Stage-specific isoforms of Ascaris suum complex. II: The fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit.
Isolation and characterization of the activated B-cell factor 1 homolog in Caenorhabditis elegans.
Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling.
Widespread genetic incompatibility in C. elegans maintained by balancing selection.
A portable regulatory element directs specific expression of the Caenorhabditis elegans ubiquitin gene ubq-2 in the somatic gonad.
Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission.
Neural integrity is maintained by dystrophin in C. elegans.
Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans.
Kinesin light chain isoforms in Caenorhabditis elegans.
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.
Mutations that lead to reiterations in the cell lineages of C. elegans.
Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes.
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.
The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth.
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans.
Molecular biological studies of the cardiac sodium-calcium exchanger.
The organization of the human gene NCX1 encoding the sodium-calcium exchanger.
An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.
Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases.
LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.
The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans.
Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans.
ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans.
C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.
The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans.
Mitochondrial endonuclease G is important for apoptosis in C. elegans.
Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans.
A gene-centered C. elegans protein-DNA interaction network.
Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin.
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function.
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum.
Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.
Specificity and complexity of the Caenorhabditis elegans innate immune response.
Studies on Shigella boydii infection in Caenorhabditis elegans and bioinformatics analysis of immune regulatory protein interactions.
Both chromosome decondensation and condensation are dependent on DNA replication in C. elegans embryos.
Identification of conserved MEL-28/ELYS domains with essential roles in nuclear assembly and chromosome segregation.
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase.
Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans.
The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans.
PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans.
The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.
Molecular cloning and characterization of a novel alpha 1,2-fucosyltransferase (CE2FT-1) from Caenorhabditis elegans.
KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover.
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
Interaction between the C. elegans cell-death regulators CED-9 and CED-4.
Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions.
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.
Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene.
The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans.
A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.
The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance.
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.
Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a developmentally regulated protein of intestine and muscle.
Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.
CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells.
Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.
Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment.
Vitellogenin-6 is a major carbonylated protein in aged nematode, Caenorhabditis elegans.
Selenocysteine-containing thioredoxin reductase in C. elegans.
The Caenorhabditis elegans homologue of thioredoxin reductase contains a selenocysteine insertion sequence (SECIS) element that differs from mammalian SECIS elements but directs selenocysteine incorporation.
Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans.
Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells.
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans.
Molecular mechanism of activation of the immunoregulatory amidase NAAA.
The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.
Caenorhabditis elegans UNC-96 is a new component of M-lines that interacts with UNC-98 and paramyosin and is required in adult muscle for assembly and/or maintenance of thick filaments.
Identification of genetic elements associated with muscle structure in the nematode Caenorhabditis elegans.
UNC-98 links an integrin-associated complex to thick filaments in Caenorhabditis elegans muscle.
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.
Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.
CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans.
Suppressors of the unc-73 gene of Caenorhabditis elegans.
The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation.
Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans.
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.
Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN.
Shugoshin is essential for meiotic prophase checkpoints in C. elegans.
Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation.
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.
Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans.
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.
A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.
C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling.
Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.
A more desirable balanced polyunsaturated fatty acid composition achieved by heterologous expression of Delta15/Delta4 desaturases in mammalian cells.
Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis.
Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids.
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.
A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis.
Caenorhabditis elegans DAF-21 (HSP90) is characteristically and predominantly expressed in germline cells: spatial and temporal analysis.
Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain.
rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.
Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.
Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.
The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.
Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.
MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans.
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.
The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis.
DPY-17 and MUA-3 interact for connective tissue-like tissue integrity in Caenorhabditis elegans: A model for Marfan Syndrome.
mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes.
Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans.
Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans.
The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.
Innexin-3 forms connexin-like intercellular channels.
Identification of Caenorhabditis elegans isovaleryl-CoA dehydrogenase and structural comparison with other acyl-CoA dehydrogenases.
Evolutionary innovation of the excretory system in Caenorhabditis elegans.
Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53.
Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans.
Novel ubiquitin-like ribosomal protein fusion genes from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development.
HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons.
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans.
Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner.
C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments.