Cloning and characterisation of PKB and PRK homologs from Hydra and the evolution of the protein kinase family.
Punctuated emergences of genetic and phenotypic innovations in eumetazoan, bilaterian, euteleostome, and hominidae ancestors.
Identification and expression of HySmad1, a member of the R-Smad family of TGFbeta signal transducers, in the diploblastic metazoan Hydra.
Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity.
Defining the origins of the NOD-like receptor system at the base of animal evolution.
Dickkopf related genes are components of the positional value gradient in Hydra.
A fragmented metazoan organellar genome: the two mitochondrial chromosomes of Hydra magnipapillata.
Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra.
Isolation of a marker for head-specific cell differentiation in hydra.
Evolution of complex structures: minicollagens shape the cnidarian nematocyst.
Characterization of taxonomically restricted genes in a phylum-restricted cell type.
Molecular evolution and expression of opsin genes in Hydra vulgaris.
Three different prohormones yield a variety of Hydra-RFamide (Arg-Phe-NH2) neuropeptides in Hydra magnipapillata.
The Wnt code: cnidarians signal the way.
Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.
HyBMP5-8b, a BMP5-8 orthologue, acts during axial patterning and tentacle formation in hydra.
Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra's innate immune system.
A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function.
HyAlx, an aristaless-related gene, is involved in tentacle formation in hydra.
Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis.
The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity.
Conservation of the nucleotide excision repair pathway: characterization of hydra Xeroderma Pigmentosum group F homolog.
Nucleotide sequence of an actin-encoding gene from Hydra attenuata: structural characteristics and evolutionary implications.
Cloning of a ras-related gene from Hydra which responds to head-specific signals.
Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling.
FoxO is a critical regulator of stem cell maintenance in immortal Hydra.
Molecular cloning and cellular distribution of two 14-3-3 isoforms from Hydra: 14-3-3 proteins respond to starvation and bind to phosphorylated targets.
Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway.
PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells.
Molecular and biological characterization of a zonula occludens-1 homologue in Hydra vulgaris, named HZO-1.
Molecular cloning of a preprohormone from Hydra magnipapillata containing multiple copies of Hydra-L Wamide (Leu-Trp-NH2) neuropeptides: evidence for processing at Ser and Asn residues.
Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra.
WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra.
Expansion of Hydra actinoporin-like toxin (HALT) gene family: expression divergence and functional convergence evolved through gene duplication.
Hydra actinoporin-like toxin-1, an unusual hemolysin from the nematocyst venom of Hydra magnipapillata which belongs to an extended gene family.
Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra.
In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides.
Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.
The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans.
Annexin XII E105K crystal structure: identification of a pH-dependent switch for mutant hexamerization.
Crystal structure of the annexin XII hexamer and implications for bilayer insertion.
Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII.
Hyzic, the Hydra homolog of the zic/odd-paired gene, is involved in the early specification of the sensory nematocytes.
Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction.
Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila.
Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris.
A fast recoiling silk-like elastomer facilitates nanosecond nematocyst discharge.
A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process.
Identification and characterization of the epithelial polarity receptor "Frizzled" in Hydra vulgaris.
Foot differentiation and genomic plasticity in Hydra: lessons from the PPOD gene family.
Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme evolution and ouabain sensitivity.
Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats.
Iodotyrosine deiodinase: a unique flavoprotein present in organisms of diverse phyla.
Molecular cloning, sequence analysis, prokaryotic expression, and function prediction of foot-specific peroxidase in Hydra magnipapillata Chinese strain.
The structural basis of Bcl-2 mediated cell death regulation in hydra.
Conservation analysis of core cell cycle regulators and their transcriptional behavior during limb regeneration in Ambystoma mexicanum.
Evolution of the gene families forming the Pax/Six regulatory network: isolation of genes from primitive animals and molecular phylogenetic analyses.
Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans.
Isolation of a putative peroxidase, a target for factors controlling foot-formation in the coelenterate hydra.
The innate immune repertoire in cnidaria--ancestral complexity and stochastic gene loss.
An ancient Wnt-Dickkopf antagonism in Hydra.
Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning.
Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation.
Continuous molecular evolution of protein-domain structures by single amino acid changes.
Nowa, a novel protein with minicollagen Cys-rich domains, is involved in nematocyst formation in Hydra.
Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
The Notch signaling pathway in the cnidarian Hydra.
A cnidarian homologue of translationally controlled tumor protein (P23/TCTP).
Characterization of hydra type IV collagen. Type IV collagen is essential for head regeneration and its expression is up-regulated upon exposure to glucose.
The collagens of hydra provide insight into the evolution of metazoan extracellular matrices.
Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata.
Upregulation of a Hydra vulgaris cPKC gene is tightly coupled to the differentiation of head structures.
The cAMP response element binding protein is involved in hydra regeneration.
Identification of a Hydra homologue of the beta-catenin/plakoglobin/armadillo gene family.
beta-catenin plays a central role in setting up the head organizer in hydra.
A Dickkopf- 3-related gene is expressed in differentiating nematocytes in the basal metazoan Hydra.
Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation.
Structure and evolution of the Fam20 kinases.
Mitochondrial DNA of Hydra attenuata (Cnidaria): a sequence that includes an end of one linear molecule and the genes for l-rRNA, tRNA(f-Met), tRNA(Trp), COII, and ATPase8.
Hydra tropomyosin TROP1 is expressed in head-specific epithelial cells and is a major component of the cytoskeletal structure that anchors nematocytes.
Probable horizontal transfer of a gene between a protist and a cnidarian.
Cilium evolution: identification of a novel protein, nematocilin, in the mechanosensory cilium of Hydra nematocytes.
Phylogenies of central element proteins reveal the dynamic evolutionary history of the Mammalian synaptonemal complex: ancient and recent components.
Trans-spliced leader addition to mRNAs in a cnidarian.
Identification of caspases and apoptosis in the simple metazoan Hydra.
Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins.
Incorporation of a horizontally transferred gene into an operon during cnidarian evolution.
Discovery of genes expressed in Hydra embryogenesis.
Evolution of gap junctions: the missing link?
Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra.
Molecular and functional evidence for early divergence of an endothelin-like system during metazoan evolution: analysis of the Cnidarian, hydra.
A possible role for the cnidarian homologue of serum response factor in decision making by undifferentiated cells.
Identification of a target protein of Hydra actinoporin-like toxin-1 (HALT-1) using GST affinity purification and SILAC-based quantitative proteomics.
Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata.
Structural and functional analysis of Hydra Actinoporin-Like Toxin 1 (HALT-1).
Ornithine decarboxylase antizyme finder (OAF): fast and reliable detection of antizymes with frameshifts in mRNAs.
The structure and expression of a preprohormone of a neuropeptide, Hym-176 in Hydra magnipapillata.
Activity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources.
Molecular characterization of two superoxide dismutases from Hydra vulgaris.
Molecular characterization of a catalase from Hydra vulgaris.