Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
Characterization of the efflux capability and substrate specificity of Aspergillus fumigatus PDR5-like ABC transporters expressed in Saccharomyces cerevisiae.
Anthranilate-activating modules from fungal nonribosomal peptide assembly lines.
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
Transcriptional control of the production of Aspergillus fumigatus conidia-borne secondary metabolite fumiquinazoline C important for phagocytosis protection.
Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb region encompassing the nitrate assimilation gene cluster.
Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia.
Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity.
Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus.
Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi.
Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.
Prototype of an intertwined secondary-metabolite supercluster.
The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competence.
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus.
Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus fumigatus.
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.
AbaA and WetA govern distinct stages of Aspergillus fumigatus development.
Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA.
Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.
In vitro antifungal activity and mode of action of 2',4'-dihydroxychalcone against Aspergillus fumigatus.
Laccases involved in 1,8-dihydroxynaphthalene melanin biosynthesis in Aspergillus fumigatus are regulated by developmental factors and copper homeostasis.
Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.
Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
TMEM16 scramblases thin the membrane to enable lipid scrambling.
The Aspergillus fumigatus sitA phosphatase homologue is important for adhesion, cell wall integrity, biofilm formation, and virulence.
Functional coupling between the unfolded protein response and endoplasmic reticulum/Golgi Ca2+-ATPases promotes stress tolerance, cell wall biosynthesis, and virulence of Aspergillus fumigatus.
The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.
Immunological characterization of Asp f 2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis.
Molecular cloning and expression of a recombinant Aspergillus fumigatus protein Asp f II with significant immunoglobulin E reactivity in allergic bronchopulmonary aspergillosis.
Acta Crystallogr. F Struct. Biol. Commun.
An ergot alkaloid biosynthesis gene and clustered hypothetical genes from Aspergillus fumigatus.
Chemotypic and genotypic diversity in the ergot alkaloid pathway of Aspergillus fumigatus.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.
Ergot: from witchcraft to biotechnology.
Formyl migration product of chanoclavine-I aldehyde in the presence of the old yellow enzyme FgaOx3 from Aspergillus fumigatus: a NMR structure elucidation.
Functional analysis of the gene controlling hydroxylation of festuclavine in the ergot alkaloid pathway of Neosartorya fumigata.
Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.
Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.
Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.
A nonredundant phosphopantetheinyl transferase, PptA, is a novel antifungal target that directs secondary metabolite, siderophore, and lysine biosynthesis in Aspergillus fumigatus and is critical for pathogenicity.
Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus.
The npgA/cfwA gene encodes a putative 4'-phosphopantetheinyl transferase which is essential for penicillin biosynthesis in Aspergillus nidulans.
Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.
Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.
Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species.
Characterization of two acetyltransferase genes in the pyripyropene biosynthetic gene cluster from Penicillium coprobium.
Characterization of two cytochrome P450 monooxygenase genes of the pyripyropene biosynthetic gene cluster from Penicillium coprobium.
Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells.
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases.
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.
Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils.
The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro.
A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus.
Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus.
Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus.
Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway.
Conidiation color mutants of Aspergillus fumigatus are highly pathogenic to the heterologous insect host Galleria mellonella.
Cutaneous model of invasive aspergillosis.
Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia.
Production of melanin by Aspergillus fumigatus.
Subcellular compartmentalization and trafficking of the biosynthetic machinery for fungal melanin.
Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response.
Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation.
Genes and molecules involved in Aspergillus fumigatus virulence.
Molecular cloning and targeted deletion of PEP2 which encodes a novel aspartic proteinase from Aspergillus fumigatus.
Glucose-6-phosphate as a probe for the glucosamine-6-phosphate N-acetyltransferase Michaelis complex.
Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.
Targeting a critical step in fungal hexosamine biosynthesis.
Crystal Structure of beta-Carbonic Anhydrase CafA from the Fungal Pathogen Aspergillus fumigatus.
Crystal Structure of beta-Carbonic Anhydrase CafA from the Fungal Pathogen pii>Aspergillus fumigatuspi/i>.
Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation.
Aspergillus fumigatus MADS-Box transcription factor rlmA is required for regulation of the cell wall integrity and virulence.
The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors.
The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus.
The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.
The cell wall integrity pathway contributes to the early stages of Aspergillus fumigatus asexual development.
Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis.
Ergosterol biosynthesis pathway in Aspergillus fumigatus.
Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus.
Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Role of the ribosomal stalk components in the resistance of Aspergillus fumigatus to the sordarin antifungals.
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1.
FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B.
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus.
Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity.
The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase.
The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus.
Acta Crystallogr Sect F Struct Biol Cryst Commun
The structure of a family GH25 lysozyme from Aspergillus fumigatus.
Functional analysis of alcS, a gene of the alc cluster in Aspergillus nidulans.
Characterization of recombinant Aspergillus fumigatus mannitol-1-phosphate 5-dehydrogenase and its application for the stereoselective synthesis of protio and deuterio forms of D-mannitol 1-phosphate.
Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase.
A soluble fucose-specific lectin from Aspergillus fumigatus conidia-- structure, specificity and possible role in fungal pathogenicity.
FleA expression in Aspergillus fumigatus is recognized by fucosylated structures on mucins and macrophages to prevent lung infection.
Molecular characterization of AfuFleA, an L-fucose-specific lectin from Aspergillus fumigatus.
Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent.
EstB-mediated hydrolysis of the siderophore triacetylfusarinine C optimizes iron uptake of Aspergillus fumigatus.
Partial reconstruction of the ergot alkaloid pathway by heterologous gene expression in Aspergillus nidulans.
Divergent targets of Aspergillus fumigatus AcuK and AcuM transcription factors during growth in vitro versus invasive disease.
Role of Aspergillus fumigatus DvrA in host cell interactions and virulence.
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.
Fumagillin treatment of intestinal microsporidiosis.
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2.
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of beta-trans-bergamotene.
The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus.
The treatment of amebiasis with fumagillin.
Thermal stabilization of the deglycating enzyme Amadoriase I by rational design.
Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus.
Tryptophan aminopeptidase activity of several indole prenyltransferases from Aspergillus fumigatus.
The Aspergillus fumigatus cellobiohydrolase B (cbhB) promoter is tightly regulated and can be exploited for controlled protein expression and RNAi.
Transcription factor somA is required for adhesion, development and virulence of the human pathogen Aspergillus fumigatus.
Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus.
Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence.
Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses.
Author Correction: Discovery of fungal surface NADases predominantly present in pathogenic species.
Discovery of fungal surface NADases predominantly present in pathogenic species.
Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free radical scavenging effects of Rumex nepalensis.
Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus.
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites.
Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus.
Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.
SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin.
Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence.
SreA-mediated iron regulation in Aspergillus fumigatus.
The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N(5)-oxygenase, is required for virulence.
The structural basis of the low catalytic activities of the two minor beta-carbonic anhydrases of the filamentous fungus Aspergillus fumigatus.
Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-alpha-1,4-galactosaminidase that disrupts microbial biofilms.
Ega3 from the fungal pathogen pii>Aspergillus fumigatuspi/i> is an endo-alpha-1,4-galactosaminidase that disrupts microbial biofilms.
Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition.
HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion.
Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.
Fungal siderophore biosynthesis is partially localized in peroxisomes.