An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.
Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638.
Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs: lessons from the Pyrococcus genomes.
Genome evolution at the genus level: comparison of three complete genomes of hyperthermophilic archaea.
A D-amino acid editing module coupled to the translational apparatus in archaea.
Mechanistic insights into cognate substrate discrimination during proofreading in translation.
Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea.
Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme.
Trapping a transition state in a computationally designed protein bottle.
The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase.
GEK1, a gene product of Arabidopsis thaliana involved in ethanol tolerance, is a D-aminoacyl-tRNA deacylase.
Identification in archaea of a novel D-Tyr-tRNATyr deacylase.
In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya.
Characterization of a small tRNA-binding protein that interacts with the archaeal proteasome complex.
Crystal structure of the archaeal asparagine synthetase: interrelation with aspartyl-tRNA and asparaginyl-tRNA synthetases.
Evidence for a Xer/dif system for chromosome resolution in archaea.
The carboxy-terminal alphaN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination.
Insights into the mechanism of progressive RNA degradation by the archaeal exosome.
Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification.
Genomewide and biochemical analyses of DNA-binding activity of Cdc6/Orc1 and Mcm proteins in Pyrococcus sp.
Sequence of plasmid pGT5 from the archaeon Pyrococcus abyssi: evidence for rolling-circle replication in a hyperthermophile.
Modulation of the Pyrococcus abyssi NucS endonuclease activity by the replication clamp PCNA at functional and structural levels.
Structure and function of a novel endonuclease acting on branched DNA substrates.
Cloning, overexpression, and characterization of a thermoactive nitrilase from the hyperthermophilic archaeon Pyrococcus abyssi.
Crystallographic analysis of a thermoactive nitrilase.
Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin. I. 0.69 A X-ray structure of mutant W4L/R5S.
Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA.
Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site.
Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI.
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Crystal structure of an archaeal glycogen synthase: insights into oligomerization and substrate binding of eukaryotic glycogen synthases.
Crystal structure of the human NK1 tachykinin receptor.
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding.
High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.
High-resolution crystal structure of the human CB1 cannabinoid receptor.
Lyase activity of glycogen synthase: Is an elimination/addition mechanism a possible reaction pathway for retaining glycosyltransferases?
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Processivity and subcellular localization of glycogen synthase depend on a non-catalytic high affinity glycogen-binding site.
Structural basis of CXC chemokine receptor 2 activation and signalling.
Structural basis of ligand recognition at the human MT1 melatonin receptor.
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode.
Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Cloning, expression, and structure analysis of carbamate kinase-like carbamoyl phosphate synthetase from Pyrococcus abyssi.
Purification, crystallization and preliminary X-ray diffraction data of L7Ae sRNP core protein from Pyrococcus abyssii.
The archaeal sRNA binding protein L7Ae has a 3D structure very similar to that of its eukaryal counterpart while having a broader RNA-binding specificity.
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro.
The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya.
Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea.
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.
Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.
Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation.
Role of aIF5B in archaeal translation initiation.
Aspartate transcarbamylase from the deep-sea hyperthermophilic archaeon Pyrococcus abyssi: genetic organization, structure, and expression in Escherichia coli.
Acquisition of a bacterial RumA-type tRNA(uracil-54, C5)-methyltransferase by Archaea through an ancient horizontal gene transfer.
The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)-methyltransferase provides insights into its tRNA specificity.
A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase.
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP.
Structure and substrate ion binding in the sodium/proton antiporter PaNhaP.
Structure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family.
Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain.
The heterodimeric primase from the euryarchaeon Pyrococcus abyssi: a multifunctional enzyme for initiation and repair?
Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19.
Crystal structures of the bifunctional tRNA methyltransferase Trm5a.
Evolution of tRNAPhe:imG2 methyltransferases involved in the biosynthesis of wyosine derivatives in Archaea.
A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases.
Expression, purification, crystallization and preliminary crystallographic analysis of the PAB0955 gene product.
Structural insights into a new homodimeric self-activated GTPase family.
Expression, purification and structural analysis of the Pyrococcus abyssi RNA binding protein PAB1135.
Isolation and characterization of pyrimidine auxotrophs, and molecular cloning of the pyrE gene from the hyperthermophilic archaeon Pyrococcus abyssi.