Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.
A story of chelatase evolution: identification and characterization of a small 13-15-kDa 'ancestral' cobaltochelatase (CbiXS) in the archaea.
Growth phase-dependent transcription of the genes that encode the two methyl coenzyme M reductase isoenzymes and N5-methyltetrahydromethanopterin:coenzyme M methyltransferase in Methanobacterium thermoautotrophicum delta H.
Phenylalanyl-tRNA synthetase from the archaeon Methanobacterium thermoautotrophicum is an (alphabeta)2 heterotetrameric protein.
Organization and growth phase-dependent transcription of methane genes in two regions of the Methanobacterium thermoautotrophicum genome.
Characterization of a 45-kDa flavoprotein and evidence for a rubredoxin, two proteins that could participate in electron transport from H2 to CO2 in methanogenesis in Methanobacterium thermoautotrophicum.
Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold.
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
Structure of the molecular chaperone prefoldin. Unique interaction of multiple coiled coil tentacles with unfolded proteins.
Evidence that the heterodisulfide of coenzyme M and 7-mercaptoheptanoylthreonine phosphate is a product of the methylreductase reaction in Methanobacterium.
Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H.
8-hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
TFE, an archaeal transcription factor in Methanobacterium thermoautotrophicum related to eucaryal transcription factor TFIIEalpha.
Minimal and RNA-free RNase P in Aquifex aeolicus.
Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein.
A recombinant exonuclease III homologue of the thermophilic archaeon Methanothermobacter thermautotrophicus.
Archaeal DNA uracil repair via direct strand incision: A minimal system reconstituted from purified components.
Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA.
DNA uracil repair initiated by the archaeal ExoIII homologue Mth212 via direct strand incision.
The Methanothermobacter thermautotrophicus ExoIII homologue Mth212 is a DNA uridine endonuclease.
Structure of the Methanothermobacter thermautotrophicus exosome RNase PH ring.
Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase.
Isolation and characterization of a split B-type DNA polymerase from the archaeon Methanobacterium thermoautotrophicum deltaH.
HMt, a histone-related protein from Methanobacterium thermoautotrophicum delta H.
A new class of DNA photolyases present in various organisms including aplacental mammals.
Sequence divergence of seryl-tRNA synthetases in archaea.
Sequence homologies in the N-terminal region of the ribosomal 'A' proteins from Methanobacterium thermoautotrophicum and Halobacterium cutirubrum.
A family of flavoproteins in the domains Archaea and Bacteria.
Methyl viologen hydrogenase II, a new member of the hydrogenase family from Methanobacterium thermoautotrophicum delta H.
Crystal structure and mechanism of a calcium-gated potassium channel.
Cloning, sequencing, and growth phase-dependent transcription of the coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin reductase-encoding genes from Methanobacterium thermoautotrophicum delta H and Methanopyrus kandleri.
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
Crystal structure of the putative adapter protein MTH1859.
Analysis of membrane stereochemistry with homology modeling of sn-glycerol-1-phosphate dehydrogenase.
Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent.
Purification and properties of sn-glycerol-1-phosphate dehydrogenase from Methanobacterium thermoautotrophicum: characterization of the biosynthetic enzyme for the enantiomeric glycerophosphate backbone of ether polar lipids of Archaea.
Transfer of pro-R hydrogen from NADH to dihydroxyacetonephosphate by sn-glycerol-1-phosphate dehydrogenase from the archaeon Methanothermobacter thermautotrophicus.
A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin.
Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins.
Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P.
Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation.
A protein engineered to bind uranyl selectively and with femtomolar affinity.
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.
Archaeal Hel308 domain V couples DNA binding to ATP hydrolysis and positions DNA for unwinding over the helicase ratchet.
Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands.
DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain.
Molecular biology of Hel308 helicase in archaea.
Physical interaction between archaeal DNA repair helicase Hel308 and replication protein A (RPA).
NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum.
Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum strain deltaH.
Sequence divergence of an archaebacterial gene cloned from a mesophilic and a thermophilic methanogen.
Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum.
Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum.
Characterization of thermophilic archaeal isopentenyl phosphate kinases.
X-ray structures of isopentenyl phosphate kinase.
Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA.
Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus.
DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase.
Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties.
The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase.
Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus.
Structure and activity of a novel archaeal beta-CASP protein with N-terminal KH domains.
An NMR approach to structural proteomics.
Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts.
Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum.
The formylmethanofuran:tetrahydromethanopterin formyltransferase from Methanobacterium thermoautotrophicum delta H. Nucleotide sequence and functional expression of the cloned gene.
Evolutionary divergence of the archaeal aspartyl-tRNA synthetases into discriminating and nondiscriminating forms.
The phosphoenolpyruvate carboxylase from Methanothermobacter thermautotrophicus has a novel structure.
An unexpected P-cluster like intermediate en route to the nitrogenase FeMo-co.
X-Ray Crystallographic Analysis of NifB with a Full Complement of Clusters: Structural Insights into the Radical SAM-Dependent Carbide Insertion During Nitrogenase Cofactor Assembly.
The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase.
Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum.
Rapid fold and structure determination of the archaeal translation elongation factor 1beta from Methanobacterium thermoautotrophicum.
The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.
Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.
Domain-specific recruitment of amide amino acids for protein synthesis.
A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Functional assignment of an enzyme that catalyzes the synthesis of an archaea-type ether lipid in bacteria.
Crystal structures of MTH1187 and its yeast ortholog YBL001c.
The 28.3 kDa FK506 binding protein from a thermophilic archaeum, Methanobacterium thermoautotrophicum, protects the denaturation of proteins in vitro.
Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli.
Deep trefoil knot implicated in RNA binding found in an archaebacterial protein.
Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum.
A unique organization of the protein subunits of the DNA polymerase clamp loader in the archaeon Methanobacterium thermoautotrophicum deltaH.
Crystallographic snapshots of iterative substrate translocations during nicotianamine synthesis in Archaea.
The crystallographic structure of thermoNicotianamine synthase with a synthetic reaction intermediate highlights the sequential processing mechanism.
X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold.
Biochemical and phylogenetic characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes identifies a diverged form of LL-diaminopimelate aminotransferase.
Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis.