9986:LOC103349172
gene id: 9986:LOC103349172
uniprot id: G1SQ26
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9986:LOC100344094
gene id: 9986:LOC100344094
uniprot id: G1SZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9986:SLC10A1
gene id: 9986:SLC10A1
uniprot id: O97736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9986:LOC100348637
gene id: 9986:LOC100348637
uniprot id: A0A5F9C8Q8
uniprot id: A0A5F9CKU1
uniprot id: G1TVG1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9986:LOC103349693
gene id: 9986:LOC103349693
uniprot id: G1TD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100347053
gene id: 9986:LOC100347053
uniprot id: A0A5F9CJS4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100338685
gene id: 9986:LOC100338685
uniprot id: A0A5F9D6X9
uniprot id: G1SEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9986:SH3GL2
gene id: 9986:SH3GL2
uniprot id: A0A088DLD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9986:SEPTIN8
gene id: 9986:SEPTIN8
uniprot id: B7NZL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Presynapse
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: synaptic vesicle membrane

9986:LOC100350694
gene id: 9986:LOC100350694
uniprot id: A0A5F9CXT3
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9986:DCT
gene id: 9986:DCT
uniprot id: H9AYE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9986:LOC100357841
gene id: 9986:LOC100357841
uniprot id: A0A5F9D9W7
uniprot id: G1SN87
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9986:LOC100350183
gene id: 9986:LOC100350183
uniprot id: A0A5F9DKC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100008789
gene id: 9986:LOC100008789
uniprot id: U3KML2
names: Subcellular Location Annotation
messages: Membrane

9986:CLCN2
gene id: 9986:CLCN2
uniprot id: P51789
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Phosphorylated. Activated by dephosphorylation.
messages: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity).
messages: Ubiquitously expressed.
messages: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity).

9986:LOC100343483
gene id: 9986:LOC100343483
uniprot id: G1TG71
names: Similarity
messages: Belongs to the mab-21 family.

9986:LOC100351835
gene id: 9986:LOC100351835
uniprot id: G1T7G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9986:LOC100342322
gene id: 9986:LOC100342322
uniprot id: Q29508
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9986:YBX1
gene id: 9986:YBX1
uniprot id: Q28618
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YBX1 family.
messages: Cleaved by a 20S proteasomal protease in response to agents that damage DNA (PubMed:16193061). Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (PubMed:16193061).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:11574481, PubMed:16354698, PubMed:7852402). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (By similarity). Component of the CRD-mediated complex that promotes MYC mRNA stability (By similarity). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (PubMed:12582179). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (By similarity). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (By similarity). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a r…
messages: Homodimer in the presence of ATP (PubMed:12582179). Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1 (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with IGF2BP1 and RBBP6 (PubMed:16354698). Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs) (PubMed:16354698). Interacts with AKT1, MBNL1, SFRS9, SFRS12, ALYREF/THOC4, MSH2, XRCC5, WRN and NCL (PubMed:16354698). Interacts (via C-terminus) with APEX1 (via N-terminus); the interaction is increased with APEX1 acetylated at 'Lys-6' and 'Lys-7' (By similarity). Interacts with AGO1 and AGO2 (By similarity). Interacts with ANKRD2 (By similarity). Interacts with DERA (By similarity). Interacts with FMR1; this interaction occurs in association with polyribosome (By similarity). Interacts with ZBTB7B (By similarity). Interacts with HDGF (By similarity). Interacts with ELAVL1; leading to ELAVL1 recruitment on C5-methylcytosine (m5C)-containing mRNAs and subsequent mRNA stability (By similarity).
messages: In the CSD domain, Trp-65 specifically recognizes C5-methylcytosine (m5C) modification through its indole ring.
messages: In the absence of phosphorylation the protein is retained in the cytoplasm (By similarity). Phosphorylation by PKB/AKT1 reduces interaction with cytoplasmic mRNA (PubMed:16354698).
messages: Nucleus
messages: Secreted
messages: Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.
messages: extracellular exosome

9986:ABRAXAS1
gene id: 9986:ABRAXAS1
uniprot id: A0A5F9DH22
uniprot id: G1T570
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9986:SLC13A2
gene id: 9986:SLC13A2
uniprot id: Q28615
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant in kidney and small intestine.
messages: Apical cell membrane
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Li(+) decreases succinate transport in the presence of Na(+), by competing at one of the three cation binding sites.
messages: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (By similarity) (PubMed:7890707, PubMed:28731330). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:7890707, PubMed:28731330). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:28731330). Has a critical role in renal dicarboxylate transport (By similarity).

9986:LOC100339381
gene id: 9986:LOC100339381
uniprot id: G1SKZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9986:LOC100354362
gene id: 9986:LOC100354362
uniprot id: G1T225
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9986:LOC100350824
gene id: 9986:LOC100350824
uniprot id: G1SW91
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9986:LOC100354678
gene id: 9986:LOC100354678
uniprot id: G1T8B6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9986:LOC100357326
gene id: 9986:LOC100357326
uniprot id: P42675
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
messages: Mitochondrion intermembrane space
messages: cytosol

9986:LOC100347153
gene id: 9986:LOC100347153
uniprot id: G1T3G7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9986:KCNS3
gene id: 9986:KCNS3
uniprot id: Q9TT17
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
messages: Cell membrane
messages: Heterotetramer with KCNB1. Does not form homomultimers.
messages: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

9986:LOC100351581
gene id: 9986:LOC100351581
uniprot id: G1T204
names: Similarity
messages: Belongs to the FAM221 family.

9986:LOC100353911
gene id: 9986:LOC100353911
uniprot id: G1SM28
names: Similarity
messages: Belongs to the NDRG family.

9986:LOC100341955
gene id: 9986:LOC100341955
uniprot id: G1T849
names: Subcellular Location Annotation
messages: nucleolus

9986:LOC100343628
gene id: 9986:LOC100343628
uniprot id: G1TIK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347828
gene id: 9986:LOC100347828
uniprot id: G1TBL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100341292
gene id: 9986:LOC100341292
uniprot id: A0A5F9CR17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9986:LOC100344511
gene id: 9986:LOC100344511
uniprot id: G1T777
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9986:LOC100346021
gene id: 9986:LOC100346021
uniprot id: G1SU51
names: Similarity
messages: Belongs to the peptidase C12 family.

9986:LOC100357563
gene id: 9986:LOC100357563
uniprot id: A0A5F9DG99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9986:LOC100353276
gene id: 9986:LOC100353276
uniprot id: A0A5F9C6K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9986:SULT3A1
gene id: 9986:SULT3A1
uniprot id: G1U045
uniprot id: O46640
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Expressed in male liver.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the N-sulfonation of amines (PTHP, aniline, 4-chloroaniline, 2-naphthylamine).

9986:LOC100356419
gene id: 9986:LOC100356419
uniprot id: A0A7R8GUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100353461
gene id: 9986:LOC100353461
uniprot id: G1TK22
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354584
gene id: 9986:LOC100354584
uniprot id: G1TCN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9986:OR51L1
gene id: 9986:OR51L1
uniprot id: B8K156
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342558
gene id: 9986:LOC100342558
uniprot id: A0A5F9CFB9
uniprot id: G1SE10
names: Similarity
messages: Belongs to the TPP enzyme family.

9986:LOC100348597
gene id: 9986:LOC100348597
uniprot id: G1T336
names: Similarity
messages: Belongs to the DEAD box helicase family.

9986:LOC100345827
gene id: 9986:LOC100345827
uniprot id: G1T075
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346143
gene id: 9986:LOC100346143
uniprot id: G1SZ01
names: Subcellular Location Annotation
messages: cilium axoneme

9986:LOC100358868
gene id: 9986:LOC100358868
uniprot id: G1SF28
names: Similarity
messages: Belongs to the TCAF family.

9986:LOC100343187
gene id: 9986:LOC100343187
uniprot id: G1SD59
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100144333
gene id: 9986:LOC100144333
uniprot id: G1TR38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9986:CSNK1A1
gene id: 9986:CSNK1A1
uniprot id: A0A5F9C8A7
uniprot id: A0A5F9CAG6
uniprot id: A0A5F9CV57
uniprot id: P67828
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration.
messages: Cytoplasm
messages: Interacts with the Axin complex (By similarity). Interacts with TUT1, leading to TUT1 phosphorylation (By similarity). Interacts with FAM83H; recruits CSNK1A1 to keratin filaments (By similarity). Interacts with FAM83D (via N-terminus); in mitotic cells (By similarity).
messages: Nucleus speckle
messages: centrosome
messages: cilium basal body
messages: kinetochore
messages: spindle

9986:LOC100339262
gene id: 9986:LOC100339262
uniprot id: A0A5F9DNJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:SDC3
gene id: 9986:SDC3
uniprot id: A0A5F9CI97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9986:LOC100354044
gene id: 9986:LOC100354044
uniprot id: G1SKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9986:LOC100341378
gene id: 9986:LOC100341378
uniprot id: A0A5F9DRD6
names: Similarity
messages: Belongs to the alpha-actinin family.

9986:LOC100348170
gene id: 9986:LOC100348170
uniprot id: G1T3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9986:LOC100351609
gene id: 9986:LOC100351609
uniprot id: A0A5F9DKU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9986:LOC100351535
gene id: 9986:LOC100351535
uniprot id: G1SVZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9986:LOC100343380
gene id: 9986:LOC100343380
uniprot id: A0A5F9CVX5
uniprot id: G1T484
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100357336
gene id: 9986:LOC100357336
uniprot id: G1SZQ8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100008909
gene id: 9986:LOC100008909
uniprot id: G1SI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9986:FBP2
gene id: 9986:FBP2
uniprot id: Q9N0J6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
messages: Cell junction
messages: Cytoplasm
messages: Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.
messages: Nucleus
messages: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose 2,6-bisphosphate acts as competitive inhibitor. Strongly inhibited by Ca(2+).
messages: Z line

9986:LOC100346884
gene id: 9986:LOC100346884
uniprot id: G1STY0
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9986:WASHC5
gene id: 9986:WASHC5
uniprot id: G1TA82
names: Similarity
messages: Belongs to the strumpellin family.

9986:LOC100340943
gene id: 9986:LOC100340943
uniprot id: G1T4B6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:OLFR582
gene id: 9986:OLFR582
uniprot id: B8K145
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345498
gene id: 9986:LOC100345498
uniprot id: A0A5F9CVF0
uniprot id: U3KPN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100358449
gene id: 9986:LOC100358449
uniprot id: G1SJ35
names: Subcellular Location Annotation
messages: Nucleus

9986:SCP2
gene id: 9986:SCP2
uniprot id: O62742
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Contains a putative mitochondrial transit peptide at positions 1-20.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family.
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane (PubMed:9711242). May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).
messages: Mitochondrion
messages: Peroxisome
messages: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).
messages: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes.

9986:LOC100353543
gene id: 9986:LOC100353543
uniprot id: G1T8B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9986:LOC100352154
gene id: 9986:LOC100352154
uniprot id: G1SUY0
names: Similarity
messages: Belongs to the STRIP family.

9986:LOC100355230
gene id: 9986:LOC100355230
uniprot id: G1STE8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100354298
gene id: 9986:LOC100354298
uniprot id: G1THS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9986:LOC100356961
gene id: 9986:LOC100356961
uniprot id: G1SRI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC103349645
gene id: 9986:LOC103349645
uniprot id: Q9TTU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9986:LOC100356218
gene id: 9986:LOC100356218
uniprot id: A0A5F9C2K3
uniprot id: G1SUA1
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9986:LOC100357651
gene id: 9986:LOC100357651
uniprot id: G1SJM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Nucleus

9986:LOC100339876
gene id: 9986:LOC100339876
uniprot id: G1U3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345875
gene id: 9986:LOC100345875
uniprot id: A0A5F9C652
uniprot id: A0A5F9CRH7
uniprot id: A0A5F9DIV3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9986:LOC100009244
gene id: 9986:LOC100009244
uniprot id: G1T4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9986:LOC100354914
gene id: 9986:LOC100354914
uniprot id: G1U4C5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100346348
gene id: 9986:LOC100346348
uniprot id: G1SJ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340121
gene id: 9986:LOC100340121
uniprot id: G1SLV6
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9986:LOC100348894
gene id: 9986:LOC100348894
uniprot id: G1TP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9986:LOC100342681
gene id: 9986:LOC100342681
uniprot id: G1U347
names: Similarity
messages: Belongs to the APC15 family.

9986:LOC100350852
gene id: 9986:LOC100350852
uniprot id: U3KP42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9986:KCNA1
gene id: 9986:KCNA1
uniprot id: G1TF99
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100355031
gene id: 9986:LOC100355031
uniprot id: G1SKP4
names: Similarity
messages: Belongs to the CRISP family.

9986:LOC100350813
gene id: 9986:LOC100350813
uniprot id: G1T0X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9986:LOC100009172
gene id: 9986:LOC100009172
uniprot id: G1T5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:SPRR3
gene id: 9986:SPRR3
uniprot id: Q28658
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cornifin (SPRR) family.
messages: Can serve as a substrate in transglutaminase-catalyzed cross linking reactions and can function as a cross-linked envelope precursor.
messages: Cytoplasm
messages: Suppressed by retinoic acid. RAR-selective retinoid is more effective than RXR-selective retinoid.
messages: Suprabasal layers of the squamous epithelia of esophagus, tongue and oral mucosa.

9986:LOC100356475
gene id: 9986:LOC100356475
uniprot id: G1SV67
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9986:LOC100350655
gene id: 9986:LOC100350655
uniprot id: A0A5F9CQ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

9986:LOC100352169
gene id: 9986:LOC100352169
uniprot id: A0A5F9CG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9986:C13H1orf52
gene id: 9986:C13H1orf52
uniprot id: G1SIC5
names: Similarity
messages: Belongs to the UPF0690 family.

9986:OR52D1 2
gene id: 9986:OR52D1_2
uniprot id: B8K196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347047
gene id: 9986:LOC100347047
uniprot id: G1T604
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9986:LOC100352988
gene id: 9986:LOC100352988
uniprot id: A0A5F9DEY3
uniprot id: A0A5F9DQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

9986:LOC100342624
gene id: 9986:LOC100342624
uniprot id: A0A5F9D8K8
uniprot id: G1SY14
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9986:LOC100344062
gene id: 9986:LOC100344062
uniprot id: A0A5F9CZS2
uniprot id: G1SKY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9986:LOC100352651
gene id: 9986:LOC100352651
uniprot id: G1T1W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9986:CYP2C16
gene id: 9986:CYP2C16
uniprot id: P15123
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital in each tissue with the exception of the kidney.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Expressed constitutively in liver, lung, testes, and kidney.
messages: Microsome membrane

9986:LOC100343293
gene id: 9986:LOC100343293
uniprot id: P61926
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
messages: The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.

9986:LOC100340589
gene id: 9986:LOC100340589
uniprot id: A0A5F9CIV9
uniprot id: A0A5F9DLJ4
uniprot id: G1T2R8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100356793
gene id: 9986:LOC100356793
uniprot id: A0A5F9D864
uniprot id: G1SGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9986:LOC100340476
gene id: 9986:LOC100340476
uniprot id: G1TL80
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100338209
gene id: 9986:LOC100338209
uniprot id: G1SL85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9986:ALKAL1
gene id: 9986:ALKAL1
uniprot id: U3KMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9986:LOC100356378
gene id: 9986:LOC100356378
uniprot id: G1TDU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9986:LOC100358401
gene id: 9986:LOC100358401
uniprot id: G1SX99
names: Similarity
messages: Belongs to the multicopper oxidase family.

9986:LOC100342365
gene id: 9986:LOC100342365
uniprot id: G1SPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9986:LOC100350961
gene id: 9986:LOC100350961
uniprot id: A0A5F9DB40
uniprot id: A0A5F9DTP6
uniprot id: G1SZA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100345012
gene id: 9986:LOC100345012
uniprot id: G1SUK6
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9986:LOC100349519
gene id: 9986:LOC100349519
uniprot id: A0A5F9D8E9
names: Similarity
messages: Belongs to the ATG8 family.

9986:LOC100346650
gene id: 9986:LOC100346650
uniprot id: G1SCS2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:LOC100346229
gene id: 9986:LOC100346229
uniprot id: A0A5F9DJG6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9986:LOC100346517
gene id: 9986:LOC100346517
uniprot id: A0A5F9CN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9986:LOC100344809
gene id: 9986:LOC100344809
uniprot id: G1T581
names: Similarity
messages: Belongs to the myozenin family.

9986:LOC127482583
gene id: 9986:LOC127482583
uniprot id: G1TAN8
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9986:FGF1
gene id: 9986:FGF1
uniprot id: B7NZB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9986:LOC100347306
gene id: 9986:LOC100347306
uniprot id: G1U2D2
names: Similarity
messages: Belongs to the mTERF family.

9986:LOC100341814
gene id: 9986:LOC100341814
uniprot id: A0A5F9CL34
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9986:LOC100355690
gene id: 9986:LOC100355690
uniprot id: G1SIK8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9986:LOC100351306
gene id: 9986:LOC100351306
uniprot id: G1U9F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100345356
gene id: 9986:LOC100345356
uniprot id: A0A5F9DH60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345849
gene id: 9986:LOC100345849
uniprot id: G1U9N3
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9986:CLIC1
gene id: 9986:CLIC1
uniprot id: Q95MF9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel CLIC family.
messages: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
messages: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion (By similarity).
messages: Nucleus
messages: Nucleus membrane

9986:TENT5D
gene id: 9986:TENT5D
uniprot id: G1SF99
names: Similarity
messages: Belongs to the TENT family.

9986:LOC100338595
gene id: 9986:LOC100338595
uniprot id: G1SYU0
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9986:LOC100355858
gene id: 9986:LOC100355858
uniprot id: A0A5F9CH11
uniprot id: G1TA12
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100338468
gene id: 9986:LOC100338468
uniprot id: G1SSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9986:LOC100350772
gene id: 9986:LOC100350772
uniprot id: G1SRP6
names: Similarity
messages: Belongs to the phosducin family.

9986:LOC100352288
gene id: 9986:LOC100352288
uniprot id: G1U390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC103351963
gene id: 9986:LOC103351963
uniprot id: G1SY35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: nucleoplasm

9986:LOC100358162
gene id: 9986:LOC100358162
uniprot id: G1U7L1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9986:LOC100355371
gene id: 9986:LOC100355371
uniprot id: G1TTM6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9986:LOC103349340
gene id: 9986:LOC103349340
uniprot id: G1U1F9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345577
gene id: 9986:LOC100345577
uniprot id: G1T3T6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100338162
gene id: 9986:LOC100338162
uniprot id: G1TJ53
names: Similarity
messages: Belongs to the EXO5 family.

9986:LOC103351911
gene id: 9986:LOC103351911
uniprot id: G1TB31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100341279
gene id: 9986:LOC100341279
uniprot id: A0A5F9DBP6
uniprot id: G1SVJ7
uniprot id: G1TWY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Cytoplasm
messages: Nucleus
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9986:LOC100338769
gene id: 9986:LOC100338769
uniprot id: G1TPK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9986:LOC100350588
gene id: 9986:LOC100350588
uniprot id: A0A5F9DUC3
uniprot id: G1SHR8
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

9986:LOC100358208
gene id: 9986:LOC100358208
uniprot id: A0A5F9CZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100343677
gene id: 9986:LOC100343677
uniprot id: G1TI93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9986:LOC103350909
gene id: 9986:LOC103350909
uniprot id: G1TSQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348968
gene id: 9986:LOC100348968
uniprot id: G1TBB5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100348249
gene id: 9986:LOC100348249
uniprot id: G1SF37
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100341050
gene id: 9986:LOC100341050
uniprot id: G1TUQ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100352164
gene id: 9986:LOC100352164
uniprot id: G1TPV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9986:LOC100359151
gene id: 9986:LOC100359151
uniprot id: G1SI31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9986:LOC100349083
gene id: 9986:LOC100349083
uniprot id: G1SD52
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100353150
gene id: 9986:LOC100353150
uniprot id: G1SDD1
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9986:LOC100345602
gene id: 9986:LOC100345602
uniprot id: A0A5F9C8R1
names: Function
names: Similarity
messages: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9986:FRZB
gene id: 9986:FRZB
uniprot id: G1SZ54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9986:OR52N4
gene id: 9986:OR52N4
uniprot id: B8K1A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339395
gene id: 9986:LOC100339395
uniprot id: G1T8J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9986:LOC100338140
gene id: 9986:LOC100338140
uniprot id: G1TGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100009470
gene id: 9986:LOC100009470
uniprot id: G1SUV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9986:LOC100341714
gene id: 9986:LOC100341714
uniprot id: A0A5F9D7F1
uniprot id: G1SNX0
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100346530
gene id: 9986:LOC100346530
uniprot id: G1U3M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355135
gene id: 9986:LOC100355135
uniprot id: A0A5F9DD04
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.

9986:LOC100351928
gene id: 9986:LOC100351928
uniprot id: G1SR98
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9986:LOC100348261
gene id: 9986:LOC100348261
uniprot id: G1TZ76
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100339693
gene id: 9986:LOC100339693
uniprot id: G1SFC7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100348424
gene id: 9986:LOC100348424
uniprot id: G1SPI4
names: Function
messages: May be involved in neurite outgrowth.

9986:CYP27A1
gene id: 9986:CYP27A1
uniprot id: P17177
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (By similarity). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (PubMed:2722778). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism. Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity).
messages: Expressed in all tissues tested. Highest expression in liver and duodenum, followed by adrenal gland and lung. Low expression in kidney and spleen.
messages: Interacts with HSP70; this interaction is required for initial targeting to mitochondria.
messages: Mitochondrion inner membrane

9986:LOC100353426
gene id: 9986:LOC100353426
uniprot id: G1SDV9
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9986:LOC100338519
gene id: 9986:LOC100338519
uniprot id: A0A5F9DBP2
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344599
gene id: 9986:LOC100344599
uniprot id: G1SK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9986:LOC100340500
gene id: 9986:LOC100340500
uniprot id: G1T671
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9986:LOC100350921
gene id: 9986:LOC100350921
uniprot id: A0A5F9DD65
uniprot id: G1SDQ2
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344945
gene id: 9986:LOC100344945
uniprot id: G1SHW3
names: Similarity
messages: Belongs to the actin family.

9986:LOC100349159
gene id: 9986:LOC100349159
uniprot id: G1U4Y9
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9986:LOC100352602
gene id: 9986:LOC100352602
uniprot id: G1TCH4
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9986:LOC100342038
gene id: 9986:LOC100342038
uniprot id: G1SK16
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9986:LOC100354520
gene id: 9986:LOC100354520
uniprot id: G1SG15
names: Similarity
messages: Belongs to the RPGRIP1 family.

9986:LOC100340783
gene id: 9986:LOC100340783
uniprot id: G1TN17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9986:LOC100351077
gene id: 9986:LOC100351077
uniprot id: G1SQU9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100348365
gene id: 9986:LOC100348365
uniprot id: G1SP25
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9986:LOC100351721
gene id: 9986:LOC100351721
uniprot id: G1TD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354154
gene id: 9986:LOC100354154
uniprot id: A0A5F9D871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:PLA2G4A
gene id: 9986:PLA2G4A
uniprot id: G1T7T8
uniprot id: Q9TT38
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by cytosolic calcium, which is necessary for binding to membrane lipids. Activated by phosphorylation in response to mitogenic stimuli.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity).
messages: Interacts with KAT5.
messages: Nucleus envelope
messages: Phosphorylated at both Ser-505 and Ser-726 in response to mitogenic stimuli.
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic calcium. In the presence of phosphoinositides, regulates phospholipase A2 and lysophospholipase activities in a calcium-independent way.

9986:LOC100348255
gene id: 9986:LOC100348255
uniprot id: A0A5F9CCF1
uniprot id: G1SDS4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344404
gene id: 9986:LOC100344404
uniprot id: A0A5F9DNA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9986:LOC100353348
gene id: 9986:LOC100353348
uniprot id: G1TAR8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353114
gene id: 9986:LOC100353114
uniprot id: A0A5F9CLQ1
uniprot id: A0A5F9CW96
uniprot id: A0A5F9DTC2
uniprot id: G1SU23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:ATP5MC2
gene id: 9986:ATP5MC2
uniprot id: G1SW65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9986:LOC100339889
gene id: 9986:LOC100339889
uniprot id: G1SQM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus

9986:UQCRQ
gene id: 9986:UQCRQ
uniprot id: G1T5S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100342014
gene id: 9986:LOC100342014
uniprot id: G1SHF7
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100355346
gene id: 9986:LOC100355346
uniprot id: A0A5F9D987
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9986:LOC100342201
gene id: 9986:LOC100342201
uniprot id: G1TCV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

9986:LOC100346625
gene id: 9986:LOC100346625
uniprot id: G1T4D5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9986:LOC100340235
gene id: 9986:LOC100340235
uniprot id: A0A5F9D4H6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100342992
gene id: 9986:LOC100342992
uniprot id: A0A5F9CHY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9986:LOC100357857
gene id: 9986:LOC100357857
uniprot id: G1SRR1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100352005
gene id: 9986:LOC100352005
uniprot id: G1SFR5
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9986:CEP20
gene id: 9986:CEP20
uniprot id: A0A5F9DNE2
uniprot id: G1T5G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9986:LOC100355617
gene id: 9986:LOC100355617
uniprot id: G1TBX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9986:LOC100341144
gene id: 9986:LOC100341144
uniprot id: G1TFL4
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9986:LOC100343154
gene id: 9986:LOC100343154
uniprot id: G1SJ89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100358056
gene id: 9986:LOC100358056
uniprot id: G1TBI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342379
gene id: 9986:LOC100342379
uniprot id: G1TP83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:CSNK2A1
gene id: 9986:CSNK2A1
uniprot id: P33674
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome.
messages: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (By similarity). Plays an…
messages: Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization (By similarity).
messages: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1, SNAI1, PML and CCAR2 (By similarity).
messages: Nucleus
messages: Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments (By similarity).

9986:LOC100345706
gene id: 9986:LOC100345706
uniprot id: A0A5F9CGR3
uniprot id: G1T8Q9
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9986:LOC100347383
gene id: 9986:LOC100347383
uniprot id: G1TUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100009379
gene id: 9986:LOC100009379
uniprot id: G1T2I6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9986:LOC103348994
gene id: 9986:LOC103348994
uniprot id: A0A5F9D7S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9986:TIMP1
gene id: 9986:TIMP1
uniprot id: P20614
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1 (By similarity).
messages: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).
messages: N-glycosylated.
messages: Secreted
messages: The activity of TIMP1 is dependent on the presence of disulfide bonds.

9986:LOC100338640
gene id: 9986:LOC100338640
uniprot id: G1SZ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9986:LOC100353261
gene id: 9986:LOC100353261
uniprot id: G1TKZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100349726
gene id: 9986:LOC100349726
uniprot id: G1U2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348018
gene id: 9986:LOC100348018
uniprot id: A0A5F9CGF1
uniprot id: G1T924
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100353637
gene id: 9986:LOC100353637
uniprot id: G1SPF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9986:LOC100351338
gene id: 9986:LOC100351338
uniprot id: G1SU02
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100358075
gene id: 9986:LOC100358075
uniprot id: G1SL79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9986:LOC100358499
gene id: 9986:LOC100358499
uniprot id: A0A5F9CS95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9986:MSTN
gene id: 9986:MSTN
uniprot id: A7LH84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9986:LOC100350734
gene id: 9986:LOC100350734
uniprot id: A0A5F9CST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9986:LOC100349678
gene id: 9986:LOC100349678
uniprot id: G1SL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9986:SLC1A1
gene id: 9986:SLC1A1
uniprot id: P31597
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily.
messages: Brain, but also small intestine, kidney, liver and heart.
messages: Cell membrane
messages: Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
messages: Early endosome membrane
messages: Homotrimer (Probable). Interacts with ARL6IP5. Interacts with RTN2 (via N-terminus); the interaction promotes cell surface expression of SLC1A1. Interacts with SORCS2; this interaction is important for normal expression at the cell membrane (By similarity).
messages: Late endosome membrane
messages: Recycling endosome membrane
messages: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1280334). Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:1280334). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).
messages: Transport does not depend on chloride.
messages: synaptosome

9986:LOC100340318
gene id: 9986:LOC100340318
uniprot id: G1TA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9986:LOC100350285
gene id: 9986:LOC100350285
uniprot id: A0A5F9CLX0
uniprot id: G1SLQ0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100353271
gene id: 9986:LOC100353271
uniprot id: G1T6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9986:LOC100350778
gene id: 9986:LOC100350778
uniprot id: G1U2R2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100351229
gene id: 9986:LOC100351229
uniprot id: G1SLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9986:LOC100353918
gene id: 9986:LOC100353918
uniprot id: G1SMW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:OR51G1
gene id: 9986:OR51G1
uniprot id: B8K154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348829
gene id: 9986:LOC100348829
uniprot id: A0A5F9CTE1
uniprot id: G1SNJ0
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9986:LOC100357602
gene id: 9986:LOC100357602
uniprot id: G1SK13
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100354561
gene id: 9986:LOC100354561
uniprot id: G1SSL0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9986:LOC100342120
gene id: 9986:LOC100342120
uniprot id: A0A5F9DIJ8
uniprot id: G1SX46
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9986:CNTF
gene id: 9986:CNTF
uniprot id: P14188
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm
messages: Nervous system.

9986:LOC100341441
gene id: 9986:LOC100341441
uniprot id: G1TGA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9986:LOC100349666
gene id: 9986:LOC100349666
uniprot id: G1TD37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100343242
gene id: 9986:LOC100343242
uniprot id: G1SUM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100340588
gene id: 9986:LOC100340588
uniprot id: G1STJ3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9986:LOC100343676
gene id: 9986:LOC100343676
uniprot id: G1T565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9986:LOC100340076
gene id: 9986:LOC100340076
uniprot id: G1T432
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9986:LOC100341490
gene id: 9986:LOC100341490
uniprot id: A0A5F9CBI9
uniprot id: G1TM56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9986:LOC100340935
gene id: 9986:LOC100340935
uniprot id: A0A5F9CHW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CALB1
gene id: 9986:CALB1
uniprot id: Q95MF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9986:LOC100344731
gene id: 9986:LOC100344731
uniprot id: G1SGS1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9986:GJC1
gene id: 9986:GJC1
uniprot id: A0A654IE22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:RLA-DMA
gene id: 9986:RLA-DMA
uniprot id: O02872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:LOC100341663
gene id: 9986:LOC100341663
uniprot id: G1SRR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343442
gene id: 9986:LOC100343442
uniprot id: G1U6Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9986:WNT2
gene id: 9986:WNT2
uniprot id: Q09YN1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

9986:LOC100344914
gene id: 9986:LOC100344914
uniprot id: G1TP83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100342541
gene id: 9986:LOC100342541
uniprot id: G1SKB7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344669
gene id: 9986:LOC100344669
uniprot id: A0A5F9DF54
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9986:LOC100346127
gene id: 9986:LOC100346127
uniprot id: A0A5F9CRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9986:LOC100339832
gene id: 9986:LOC100339832
uniprot id: G1SRL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9986:TACR3
gene id: 9986:TACR3
uniprot id: O97512
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

9986:LOC100341355
gene id: 9986:LOC100341355
uniprot id: G1TXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346225
gene id: 9986:LOC100346225
uniprot id: A0A5F9C1H6
uniprot id: A0A5F9CV51
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:RPL32
gene id: 9986:RPL32
uniprot id: B7NZB5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9986:LOC100348731
gene id: 9986:LOC100348731
uniprot id: U3KLW4
names: Similarity
messages: Belongs to the TCP11 family.

9986:SLC10A2
gene id: 9986:SLC10A2
uniprot id: Q28727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.
messages: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10484607). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10484607). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).

9986:LOC100341234
gene id: 9986:LOC100341234
uniprot id: G1TI39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9986:LOC100349487
gene id: 9986:LOC100349487
uniprot id: G1TCU4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100352533
gene id: 9986:LOC100352533
uniprot id: G1TYU3
names: Similarity
messages: Belongs to the yippee family.

9986:LOC100346294
gene id: 9986:LOC100346294
uniprot id: A0A5F9DQW7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9986:LOC100356690
gene id: 9986:LOC100356690
uniprot id: G1TA71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9986:LOC100344498
gene id: 9986:LOC100344498
uniprot id: G1SPZ8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9986:PRLR
gene id: 9986:PRLR
uniprot id: P14787
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9986:DYNLT4
gene id: 9986:DYNLT4
uniprot id: G1T3D5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9986:KEF51 p08
gene id: 9986:KEF51_p08
uniprot id: A0A3S8V6T8
uniprot id: O79432
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9986:LOC100347125
gene id: 9986:LOC100347125
uniprot id: G1TZX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358759
gene id: 9986:LOC100358759
uniprot id: A0A5F9D707
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100338322
gene id: 9986:LOC100338322
uniprot id: G1TPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352419
gene id: 9986:LOC100352419
uniprot id: G1SPV8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9986:KIT
gene id: 9986:KIT
uniprot id: A0A059VJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100342468
gene id: 9986:LOC100342468
uniprot id: G1T1A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100356176
gene id: 9986:LOC100356176
uniprot id: G1T2H7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100353468
gene id: 9986:LOC100353468
uniprot id: G1TI54
names: Similarity
messages: Belongs to the histone H2B family.

9986:LOC100344181
gene id: 9986:LOC100344181
uniprot id: G1SDL3
names: Subcellular Location Annotation
messages: Lysosome

9986:LOC100357633
gene id: 9986:LOC100357633
uniprot id: G1SU83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100346300
gene id: 9986:LOC100346300
uniprot id: G1T659
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9986:LOC100353755
gene id: 9986:LOC100353755
uniprot id: G1U3C3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9986:LOC100358773
gene id: 9986:LOC100358773
uniprot id: G1SDV0
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9986:LOC100343740
gene id: 9986:LOC100343740
uniprot id: G1T2V2
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9986:ELL3
gene id: 9986:ELL3
uniprot id: B7NZF2
uniprot id: G1SEV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9986:LOC100356635
gene id: 9986:LOC100356635
uniprot id: G1U002
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100356802
gene id: 9986:LOC100356802
uniprot id: G1SWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100353415
gene id: 9986:LOC100353415
uniprot id: G1U9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9986:LOC100339987
gene id: 9986:LOC100339987
uniprot id: G1SX19
names: Subcellular Location Annotation
messages: Membrane

9986:TNFSF13B
gene id: 9986:TNFSF13B
uniprot id: A4UIM6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9986:LOC100350313
gene id: 9986:LOC100350313
uniprot id: A0A5F9DP77
uniprot id: G1TNE0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:KDR
gene id: 9986:KDR
uniprot id: G1SN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100345858
gene id: 9986:LOC100345858
uniprot id: G1TB66
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9986:LOC100354557
gene id: 9986:LOC100354557
uniprot id: A0A5F9DJM1
names: Similarity
messages: Belongs to the PDCD4 family.

9986:LOC100356801
gene id: 9986:LOC100356801
uniprot id: A0A5F9CD80
uniprot id: A0A5F9DP54
uniprot id: G1SQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9986:LOC100355881
gene id: 9986:LOC100355881
uniprot id: A0A5F9C5R3
uniprot id: A0A5F9D6B5
uniprot id: A0A5F9DSW7
uniprot id: G1TBP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9986:LOC100354429
gene id: 9986:LOC100354429
uniprot id: G1U197
names: Similarity
messages: Belongs to the apolipoprotein L family.

9986:LOC100350205
gene id: 9986:LOC100350205
uniprot id: A0A5F9D376
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9986:CKMT2
gene id: 9986:CKMT2
uniprot id: O77814
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Exists as an octamer composed of four CKMT2 homodimers.
messages: Mitochondrial creatine kinase binds cardiolipin.
messages: Mitochondrion inner membrane
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

9986:LOC100342138
gene id: 9986:LOC100342138
uniprot id: G1SNY3
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9986:LOC100340860
gene id: 9986:LOC100340860
uniprot id: G1T4P0
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100357171
gene id: 9986:LOC100357171
uniprot id: G1SGG0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:CA4
gene id: 9986:CA4
uniprot id: P48283
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
messages: Cell membrane
messages: Inhibited by acetazolamide.
messages: Interacts with SLC4A4.

9986:LOC100345788
gene id: 9986:LOC100345788
uniprot id: A0A5F9CNB0
uniprot id: G1SMK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100350665
gene id: 9986:LOC100350665
uniprot id: G1SQQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9986:SLMAP
gene id: 9986:SLMAP
uniprot id: Q28623
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SLMAP family.
messages: Expressed in heart (at protein level). Expressed in heart, skeletal muscle, smooth muscle, kidney, spleen, pancreas and brain.
messages: Homodimer (By similarity). Interacts with myosin.
messages: May play a role during myoblast fusion.
messages: centrosome
messages: sarcolemma

9986:LOC100342990
gene id: 9986:LOC100342990
uniprot id: G1SER6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343798
gene id: 9986:LOC100343798
uniprot id: G1SUZ6
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9986:LOC100352531
gene id: 9986:LOC100352531
uniprot id: G1T455
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9986:LOC100350754
gene id: 9986:LOC100350754
uniprot id: G1TSY5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9986:LOC100355225
gene id: 9986:LOC100355225
uniprot id: A0A5F9CFA6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100346739
gene id: 9986:LOC100346739
uniprot id: G1T2Y5
names: Similarity
messages: Belongs to the TPR family.

9986:LOC100347676
gene id: 9986:LOC100347676
uniprot id: G1SGJ7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100008858
gene id: 9986:LOC100008858
uniprot id: G1SH13
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339955
gene id: 9986:LOC100339955
uniprot id: G1SMM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100008950
gene id: 9986:LOC100008950
uniprot id: G1SWR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9986:LOC100350996
gene id: 9986:LOC100350996
uniprot id: G1T8S2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9986:LOC100344673
gene id: 9986:LOC100344673
uniprot id: A0A5F9CX05
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

9986:LOC100353284
gene id: 9986:LOC100353284
uniprot id: G1SW81
names: Similarity
messages: Belongs to the GADD45 family.

9986:LOC100339391
gene id: 9986:LOC100339391
uniprot id: G1SZ12
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9986:S100A6
gene id: 9986:S100A6
uniprot id: P30801
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity).
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
messages: Nucleus envelope

9986:LOC100358970
gene id: 9986:LOC100358970
uniprot id: G1T619
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100346558
gene id: 9986:LOC100346558
uniprot id: P84246
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed throughout the cell cycle independently of DNA synthesis.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity).
messages: Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9986:LOC100354082
gene id: 9986:LOC100354082
uniprot id: A0A5F9CFG8
uniprot id: G1SE72
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9986:LOC100356976
gene id: 9986:LOC100356976
uniprot id: G1SS91
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse
messages: axon
messages: dendrite

9986:LOC100341343
gene id: 9986:LOC100341343
uniprot id: G1T5I5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9986:LOC100345678
gene id: 9986:LOC100345678
uniprot id: G1TG81
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100349997
gene id: 9986:LOC100349997
uniprot id: G1SQF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9986:LOC100353606
gene id: 9986:LOC100353606
uniprot id: G1TU13
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9986:LOC100339773
gene id: 9986:LOC100339773
uniprot id: G1SPN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9986:LOC100342327
gene id: 9986:LOC100342327
uniprot id: G1SE50
names: Similarity
messages: Belongs to the CRK family.

9986:LOC100346034
gene id: 9986:LOC100346034
uniprot id: G1T2M7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100356725
gene id: 9986:LOC100356725
uniprot id: G1TTL5
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9986:LOC100340437
gene id: 9986:LOC100340437
uniprot id: G1TBN2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9986:LOC100350680
gene id: 9986:LOC100350680
uniprot id: G1SZY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9986:LOC100345302
gene id: 9986:LOC100345302
uniprot id: G1THS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340271
gene id: 9986:LOC100340271
uniprot id: G1TU51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:C8A
gene id: 9986:C8A
uniprot id: A0A5F9CGU8
uniprot id: A0A5F9CKQ3
uniprot id: P98136
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity).
messages: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100352402
gene id: 9986:LOC100352402
uniprot id: G1SH25
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9986:LOC100351990
gene id: 9986:LOC100351990
uniprot id: A0A5F9DCP2
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9986:LOC100351589
gene id: 9986:LOC100351589
uniprot id: A0A5F9CTD8
uniprot id: G1SGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9986:LOC100344433
gene id: 9986:LOC100344433
uniprot id: G1TBF7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9986:C7H2orf88
gene id: 9986:C7H2orf88
uniprot id: G1U5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9986:LOC100349266
gene id: 9986:LOC100349266
uniprot id: G1T6L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9986:MYL1
gene id: 9986:MYL1
uniprot id: P02602
names: Function
names: PTM
names: Subunit
messages: Isoform MLC3 is acetylated at position 2.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains. Does not bind calcium.
messages: Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.

9986:LOC100338236
gene id: 9986:LOC100338236
uniprot id: G1TGM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100346720
gene id: 9986:LOC100346720
uniprot id: G1SRF0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100357800
gene id: 9986:LOC100357800
uniprot id: G1TSH0
names: Similarity
messages: Belongs to the RELT family.

9986:LOC100356287
gene id: 9986:LOC100356287
uniprot id: G1SV90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9986:ANXA8
gene id: 9986:ANXA8
uniprot id: O97529
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9986:LOC100345945
gene id: 9986:LOC100345945
uniprot id: G1SFR8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9986:LOC100358971
gene id: 9986:LOC100358971
uniprot id: G1SF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9986:TINAG
gene id: 9986:TINAG
uniprot id: Q28625
names: Similarity
messages: Belongs to the peptidase C1 family.

9986:LOC100354669
gene id: 9986:LOC100354669
uniprot id: G1U2P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:OLFR639
gene id: 9986:OLFR639
uniprot id: B8K183
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345314
gene id: 9986:LOC100345314
uniprot id: G1SEM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9986:LOC100342113
gene id: 9986:LOC100342113
uniprot id: A0A5F9DNW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9986:LOC100348229
gene id: 9986:LOC100348229
uniprot id: A0A5F9CA49
uniprot id: G1T6D6
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100351886
gene id: 9986:LOC100351886
uniprot id: G1SQH6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100342631
gene id: 9986:LOC100342631
uniprot id: G1SQ22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9986:LOC100339082
gene id: 9986:LOC100339082
uniprot id: G1TEN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9986:LOC100351977
gene id: 9986:LOC100351977
uniprot id: G1SPI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343720
gene id: 9986:LOC100343720
uniprot id: G1SUN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9986:LOC100351647
gene id: 9986:LOC100351647
uniprot id: G1SLE1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9986:LOC100342818
gene id: 9986:LOC100342818
uniprot id: G1T412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9986:LOC100341713
gene id: 9986:LOC100341713
uniprot id: G1SYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9986:CZIB
gene id: 9986:CZIB
uniprot id: G1T461
names: Similarity
messages: Belongs to the UPF0587 family.

9986:LOC100355072
gene id: 9986:LOC100355072
uniprot id: G1U5W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9986:LOC100347146
gene id: 9986:LOC100347146
uniprot id: G1SY84
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9986:LOC100350378
gene id: 9986:LOC100350378
uniprot id: G1T1M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357297
gene id: 9986:LOC100357297
uniprot id: A0A5F9CZZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9986:LOC100357414
gene id: 9986:LOC100357414
uniprot id: G1TNA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349568
gene id: 9986:LOC100349568
uniprot id: G1U949
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9986:LOC100352476
gene id: 9986:LOC100352476
uniprot id: G1TWU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:ITIH3
gene id: 9986:ITIH3
uniprot id: Q9GLY5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITIH family.
messages: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Pre-alpha-inhibitor (P-alpha-I) is composed of ITIH3/HC3 and bikunin.
messages: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
messages: Secreted

9986:SLC47A2
gene id: 9986:SLC47A2
uniprot id: A7KAU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Expressed in renal cortical tissues.
messages: It is uncertain whether Met-1 or Met-30 is the initiator.
messages: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17442726). Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+) or weak bases that are positively charged at physiological pH, cimetidine or the antidiabetic drug metformin. Mediates the efflux of the endogenous compounds creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney (By similarity).

9986:LOC100340674
gene id: 9986:LOC100340674
uniprot id: G1SX04
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9986:LOC100008790
gene id: 9986:LOC100008790
uniprot id: G1SLQ4
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9986:LOC100347135
gene id: 9986:LOC100347135
uniprot id: G1SRF7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9986:LOC100357899
gene id: 9986:LOC100357899
uniprot id: G1TH64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9986:LOC100350040
gene id: 9986:LOC100350040
uniprot id: G1SV06
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9986:SEMA6C
gene id: 9986:SEMA6C
uniprot id: B7NZC6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:ERGIC3
gene id: 9986:ERGIC3
uniprot id: B7NZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9986:LOC100349320
gene id: 9986:LOC100349320
uniprot id: G1SV75
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9986:LOC100355129
gene id: 9986:LOC100355129
uniprot id: G1SIW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9986:LOC100355428
gene id: 9986:LOC100355428
uniprot id: G1SIN0
names: Similarity
messages: Belongs to the peptidase M10A family.

9986:LOC100354058
gene id: 9986:LOC100354058
uniprot id: G1U4Z2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100348746
gene id: 9986:LOC100348746
uniprot id: A0A5F9D5M1
uniprot id: G1TCJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9986:LOC100353691
gene id: 9986:LOC100353691
uniprot id: G1TE68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100354191
gene id: 9986:LOC100354191
uniprot id: A0A5F9D5C0
names: Similarity
messages: Belongs to the LTV1 family.

9986:CD247
gene id: 9986:CD247
uniprot id: Q9TUF8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The ITAM domains mediate interaction with SHB.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with SLA. Interacts with TRAT1. Interacts with DOCK2. Interacts with SLA2. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC. Interacts with CRK; this interaction regulates CD3Z phosphorylation. Interacts (on T cell side) with CD81, ICAM1 and CD9 at immunological synapses between antigen-presenting cells and T cells. Interacts with CD160. Interacts with LY6E. Interacts with LY6E (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer with FCER1G, associates with the ligand binding subunit FCGR3A (via transmembrane domain); this interaction is a prerequisite for Fc receptor complex expression on the cell surface.

9986:LOC100008702
gene id: 9986:LOC100008702
uniprot id: G1U522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9986:LOC100353681
gene id: 9986:LOC100353681
uniprot id: A0A5F9D1L9
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9986:CYP4A5
gene id: 9986:CYP4A5
uniprot id: P14579
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9986:ADORA3
gene id: 9986:ADORA3
uniprot id: Q9N1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9986:LOC100351425
gene id: 9986:LOC100351425
uniprot id: G1T522
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9986:LOC100350829
gene id: 9986:LOC100350829
uniprot id: G1SUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344763
gene id: 9986:LOC100344763
uniprot id: G1U785
names: Similarity
messages: Belongs to the yippee family.

9986:KCNK10
gene id: 9986:KCNK10
uniprot id: Q6Q834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9986:LOC100352940
gene id: 9986:LOC100352940
uniprot id: G1SVN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100345762
gene id: 9986:LOC100345762
uniprot id: G1SGS4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100351398
gene id: 9986:LOC100351398
uniprot id: A0A5F9CZS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9986:LOC103348637
gene id: 9986:LOC103348637
uniprot id: A0A5F9CBA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9986:SLC2A4
gene id: 9986:SLC2A4
uniprot id: Q6VGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9986:LOC100349001
gene id: 9986:LOC100349001
uniprot id: A0A5F9CPZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100347221
gene id: 9986:LOC100347221
uniprot id: G1SKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9986:LOC100345792
gene id: 9986:LOC100345792
uniprot id: G1T1T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9986:LOC100352283
gene id: 9986:LOC100352283
uniprot id: G1T5T8
names: Subcellular Location Annotation
messages: Z line

9986:LOC100339727
gene id: 9986:LOC100339727
uniprot id: G1SCQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9986:LOC100346598
gene id: 9986:LOC100346598
uniprot id: G1TLS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:AOX2
gene id: 9986:AOX2
uniprot id: G1U6Q8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9986:LOC103348216
gene id: 9986:LOC103348216
uniprot id: G1T8N8
names: Similarity
messages: Belongs to the frataxin family.

9986:LOC100342502
gene id: 9986:LOC100342502
uniprot id: G1TLR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358266
gene id: 9986:LOC100358266
uniprot id: G1TFA5
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100344100
gene id: 9986:LOC100344100
uniprot id: A0A5F9D8I2
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9986:LOC100343332
gene id: 9986:LOC100343332
uniprot id: G1U688
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348660
gene id: 9986:LOC100348660
uniprot id: G1T6E0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100358620
gene id: 9986:LOC100358620
uniprot id: A0A5F9D6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:OR52D1 1
gene id: 9986:OR52D1_1
uniprot id: B8K195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340170
gene id: 9986:LOC100340170
uniprot id: G1THW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CRYBA1
gene id: 9986:CRYBA1
uniprot id: Q95KK6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9986:LOC100355396
gene id: 9986:LOC100355396
uniprot id: G1T148
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9986:LOC100345357
gene id: 9986:LOC100345357
uniprot id: A0A5F9D5W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9986:LOC100358092
gene id: 9986:LOC100358092
uniprot id: A0A5F9DKS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100343141
gene id: 9986:LOC100343141
uniprot id: G1TP83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100357859
gene id: 9986:LOC100357859
uniprot id: G1T3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100343124
gene id: 9986:LOC100343124
uniprot id: G1U1P7
names: Similarity
messages: Belongs to the NDK family.

9986:LOC100358381
gene id: 9986:LOC100358381
uniprot id: G1TNQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9986:OLFR643 1
gene id: 9986:OLFR643_1
uniprot id: B8K187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:ACE
gene id: 9986:ACE
uniprot id: P12822
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 3 chloride ions per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (PubMed:7902354, PubMed:8171037). Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (By similarity). Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (PubMed:7902354). Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (By similarity). Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (By similarity). Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (By similarity). Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin (By similarity). Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing pl…
messages: Isoform Testis-specific only binds 1 Zn(2+) ion per subunit.
messages: Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility (By similarity). In contrast to somatic isoforms, only contains one catalytic domain (By similarity). Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates (PubMed:7902354). The identity of substrates that are needed for male fertility is unknown (By similarity). May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity). The GPIase activity was reported to be essential for the egg-binding ability of the sperm (By similarity). This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (PubMed:16270062).
messages: Monomer and homodimer; homodimerizes following binding to an inhibitor (By similarity). Interacts with calmodulin (CALM1, CALM2 or CALM3); interaction takes place in the cytoplasmic region and regulates phosphorylation and proteolytic cleavage (PubMed:16096279).
messages: N-glycosylated.
messages: Phosphorylated by CK2 on Ser-1303; which allows membrane retention (By similarity). Phosphorylated on tyrosine residues on its extracellular part, promoting cleavage by secretase enzymes and formation of the soluble form (Angiotensin-converting enzyme, soluble form) (PubMed:15252021).
messages: Produced following proteolytic cleavage by secretase enzymes that cleave the transmembrane form in the juxtamembrane stalk region upstream of the transmembrane region (PubMed:15252021, PubMed:16096279). Cleavage can take place at different sites of the juxtamembrane stalk region (By similarity).
messages: Secreted
messages: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.
messages: Strongly inhibited by lisinopril and captopril.
messages: Testis-specific isoform is expressed in spermatocytes, adult testis.
messages: The dipeptidyl carboxypeptidase activity is strongly activated by chloride (By similarity). Specifically inhibited by lisinopril (PubMed:7902354). Inhibited by mixanpril, an orally-active drug used for the treatment of hypertension (PubMed:8171037).

9986:LOC100351672
gene id: 9986:LOC100351672
uniprot id: G1SJS1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100342947
gene id: 9986:LOC100342947
uniprot id: G1TDD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:FGF5
gene id: 9986:FGF5
uniprot id: G1T394
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9986:LOC100338090
gene id: 9986:LOC100338090
uniprot id: G1TEE0
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9986:LOC100339098
gene id: 9986:LOC100339098
uniprot id: G1SPD2
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9986:LOC108175353
gene id: 9986:LOC108175353
uniprot id: G1T3I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9986:LOC100352057
gene id: 9986:LOC100352057
uniprot id: G1TJW1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9986:LOC100354202
gene id: 9986:LOC100354202
uniprot id: A0A5F9CAR5
uniprot id: A0A5F9DF14
uniprot id: A0A5F9DK03
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100353916
gene id: 9986:LOC100353916
uniprot id: G1SK10
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9986:LOC100345210
gene id: 9986:LOC100345210
uniprot id: G1SJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9986:LOC100344890
gene id: 9986:LOC100344890
uniprot id: G1SL90
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100350608
gene id: 9986:LOC100350608
uniprot id: G1T5Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9986:LOC100356796
gene id: 9986:LOC100356796
uniprot id: G1SYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9986:LOC100350070
gene id: 9986:LOC100350070
uniprot id: G1SIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9986:LOC103349854
gene id: 9986:LOC103349854
uniprot id: G1TAS7
names: Subcellular Location Annotation
messages: Membrane

9986:S100A9
gene id: 9986:S100A9
uniprot id: P50117
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A8 known as calprotectin (S100A8/A9) (By similarity). S100A9 interacts with ATP2A2 (By similarity). S100A9 interacts with AGER, and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. S100A9 binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions. S100A9 interacts with amyloid-beta protein 40. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. Calprotectin (S100A8/9) interacts with NCF2/P67PHOX, RAC1, RAC2, CYBA and CYBB. Calprotectin (S100A8/9) interacts with NOS2 to form the iNOS-S100A8/A9 transnitrosylase complex; induced by LDL(ox) (By similarity).
messages: Methylation at His-107 by METTL9 reduces zinc-binding without affecting heterodimerization with S100A8.
messages: Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.
messages: S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the proce…
messages: Secreted
messages: cytoskeleton

9986:DBI
gene id: 9986:DBI
uniprot id: Q8WN94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Monomer.

9986:LOC100341175
gene id: 9986:LOC100341175
uniprot id: G1U0B4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100345155
gene id: 9986:LOC100345155
uniprot id: G1U3W7
names: Subcellular Location Annotation
messages: nucleoplasm

9986:LOC100340092
gene id: 9986:LOC100340092
uniprot id: G1SPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9986:LOC100339623
gene id: 9986:LOC100339623
uniprot id: G1TQL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100345013
gene id: 9986:LOC100345013
uniprot id: G1T895
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9986:LOC100338225
gene id: 9986:LOC100338225
uniprot id: G1TGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347155
gene id: 9986:LOC100347155
uniprot id: A0A5F9D0A0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100343041
gene id: 9986:LOC100343041
uniprot id: G1TQN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:PWWP3B
gene id: 9986:PWWP3B
uniprot id: G1SWL5
names: Similarity
messages: Belongs to the PWWP3A family.

9986:LOC100358091
gene id: 9986:LOC100358091
uniprot id: G1TBK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9986:LOC100346886
gene id: 9986:LOC100346886
uniprot id: A0A5F9DEU6
uniprot id: G1SY40
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9986:LOC100342486
gene id: 9986:LOC100342486
uniprot id: G1SQ45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9986:LOC100341045
gene id: 9986:LOC100341045
uniprot id: G1TG94
names: Similarity
messages: Belongs to the DEAD box helicase family.

9986:LOC100338502
gene id: 9986:LOC100338502
uniprot id: G1T9A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9986:LOC100340118
gene id: 9986:LOC100340118
uniprot id: A0A5F9CE22
uniprot id: A0A5F9CYE9
uniprot id: A0A5F9CZN3
uniprot id: A0A5F9D401
uniprot id: A0A5F9D7E5
uniprot id: A0A5F9DCD0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9986:LOC100339970
gene id: 9986:LOC100339970
uniprot id: G1SUN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100338544
gene id: 9986:LOC100338544
uniprot id: G1T817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9986:LOC100338298
gene id: 9986:LOC100338298
uniprot id: G1TV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC103350782
gene id: 9986:LOC103350782
uniprot id: G1TTD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9986:LOC100009343
gene id: 9986:LOC100009343
uniprot id: G1TPK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

9986:LOC100359124
gene id: 9986:LOC100359124
uniprot id: G1T9U6
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9986:LOC100338516
gene id: 9986:LOC100338516
uniprot id: G1SXY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9986:SGCA
gene id: 9986:SGCA
uniprot id: Q28686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity). Interacts with the syntrophin SNTA1.
messages: cytoskeleton
messages: sarcolemma

9986:LOC100343655
gene id: 9986:LOC100343655
uniprot id: G1T107
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100358981
gene id: 9986:LOC100358981
uniprot id: G1SVG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9986:KCNK1
gene id: 9986:KCNK1
uniprot id: Q5UE96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Expressed in renal distal tubules, especially in cortical collecting duct and cortical thick ascending limb, with lower levels in the connecting tubule.
messages: Homodimer; disulfide-linked (By similarity). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (By similarity). Interacts with GNG4 (By similarity). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity). Interacts with UBE2I (By similarity).
messages: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endo…
messages: Perikaryon
messages: Recycling endosome
messages: Sumoylation is controversial. Sumoylated by UBE2I. Not sumoylated when expressed in xenopus oocytes or mammalian cells. Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane. Sumoylation of a single subunit is sufficient to silence the dimeric channel. Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9. Desumoylated by SENP1; this activates the channel. Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9. SENP1 treatment has no effect.
messages: Synaptic cell membrane
messages: dendrite

9986:LOC100350642
gene id: 9986:LOC100350642
uniprot id: G1T8H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9986:LOC100340705
gene id: 9986:LOC100340705
uniprot id: G1SM74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9986:LOC100353792
gene id: 9986:LOC100353792
uniprot id: G1U552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357546
gene id: 9986:LOC100357546
uniprot id: G1SCV9
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9986:LOC100337900
gene id: 9986:LOC100337900
uniprot id: A0A5F9DIG7
uniprot id: G1T6U1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100350567
gene id: 9986:LOC100350567
uniprot id: G1SWH6
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9986:LOC100356230
gene id: 9986:LOC100356230
uniprot id: G1TA52
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9986:LOC100357258
gene id: 9986:LOC100357258
uniprot id: A0A5F9DAZ4
uniprot id: G1T1K0
names: Similarity
messages: Belongs to the MAGUK family.

9986:KCNJ2
gene id: 9986:KCNJ2
uniprot id: P49656
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Highly expressed in the ventricle and skeletal muscle, moderately in cerebrum and cerebellum. Only low levels are detected in kidney or lung.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
messages: Membrane
messages: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
messages: S-nitrosylation increases the open probability and inward rectifying currents.

9986:APOA4
gene id: 9986:APOA4
uniprot id: B7NZM0
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9986:PTGER2
gene id: 9986:PTGER2
uniprot id: Q8HY57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100341283
gene id: 9986:LOC100341283
uniprot id: G1U9F0
names: Similarity
messages: Belongs to the cystatin family.

9986:LOC100356533
gene id: 9986:LOC100356533
uniprot id: G1TXL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9986:LOC100340769
gene id: 9986:LOC100340769
uniprot id: U3KMB3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9986:LOC100357848
gene id: 9986:LOC100357848
uniprot id: G1TFS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9986:LOC100344959
gene id: 9986:LOC100344959
uniprot id: G1TEK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9986:LOC100349440
gene id: 9986:LOC100349440
uniprot id: G1T717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100350503
gene id: 9986:LOC100350503
uniprot id: G1TR51
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100341605
gene id: 9986:LOC100341605
uniprot id: G1SL29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9986:LOC100345681
gene id: 9986:LOC100345681
uniprot id: A0A5F9D0P0
uniprot id: G1U8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9986:PRNP
gene id: 9986:PRNP
uniprot id: Q95211
uniprot id: Q9TSF8
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Membrane
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9986:LOC100358418
gene id: 9986:LOC100358418
uniprot id: G1TW79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9986:VTN
gene id: 9986:VTN
uniprot id: P22458
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with SERPINE1/PAI1 and C1QBP (By similarity). Monomer.
messages: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
messages: N- and O-glycosylated.
messages: Plasma.
messages: Sulfated on tyrosine residues.
messages: The SMB domain mediates interaction with SERPINE1/PAI1.
messages: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
messages: extracellular space

9986:LOC100358951
gene id: 9986:LOC100358951
uniprot id: A0A5F9CP68
uniprot id: G1TDF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9986:LOC108178831
gene id: 9986:LOC108178831
uniprot id: G1SYU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9986:LOC100341183
gene id: 9986:LOC100341183
uniprot id: G1SNC7
names: Similarity
messages: Belongs to the dermatopontin family.

9986:LOC100343290
gene id: 9986:LOC100343290
uniprot id: A0A5F9CJ33
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9986:LOC100343418
gene id: 9986:LOC100343418
uniprot id: G1SM05
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9986:SSPN
gene id: 9986:SSPN
uniprot id: P82352
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.
messages: Postsynaptic cell membrane
messages: sarcolemma

9986:LOC100346381
gene id: 9986:LOC100346381
uniprot id: A0A5F9D5T7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9986:LOC100339579
gene id: 9986:LOC100339579
uniprot id: G1SSD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9986:LOC100356065
gene id: 9986:LOC100356065
uniprot id: G1U7K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9986:LOC100357674
gene id: 9986:LOC100357674
uniprot id: G1SMY4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9986:AGTR2
gene id: 9986:AGTR2
uniprot id: Q8MKE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9986:LOC100340387
gene id: 9986:LOC100340387
uniprot id: G1SJR2
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9986:LOC100358494
gene id: 9986:LOC100358494
uniprot id: U3KM75
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100338181
gene id: 9986:LOC100338181
uniprot id: G1SLB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9986:LOC100339774
gene id: 9986:LOC100339774
uniprot id: G1SXU0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100353361
gene id: 9986:LOC100353361
uniprot id: G1U4H0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9986:LOC100347526
gene id: 9986:LOC100347526
uniprot id: G1TYZ6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100338988
gene id: 9986:LOC100338988
uniprot id: G1T370
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100338177
gene id: 9986:LOC100338177
uniprot id: G1U2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:HARS1
gene id: 9986:HARS1
uniprot id: G1SLD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9986:LOC100352423
gene id: 9986:LOC100352423
uniprot id: G1U1S4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100349178
gene id: 9986:LOC100349178
uniprot id: G1SLX0
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9986:LOC100347274
gene id: 9986:LOC100347274
uniprot id: G1TB37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9986:LOC100350875
gene id: 9986:LOC100350875
uniprot id: G1SI27
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345339
gene id: 9986:LOC100345339
uniprot id: G1T185
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9986:LOC100344168
gene id: 9986:LOC100344168
uniprot id: G1SXN1
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100342636
gene id: 9986:LOC100342636
uniprot id: G1SS94
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:LOC100347270
gene id: 9986:LOC100347270
uniprot id: G1T523
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9986:LOC100353646
gene id: 9986:LOC100353646
uniprot id: G1SM54
names: Similarity
messages: Belongs to the CWC26 family.

9986:LOC100354464
gene id: 9986:LOC100354464
uniprot id: G1SF92
uniprot id: U3KPG0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9986:LOC100351067
gene id: 9986:LOC100351067
uniprot id: G1SWX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9986:LOC100343053
gene id: 9986:LOC100343053
uniprot id: G1SZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9986:LOC100350848
gene id: 9986:LOC100350848
uniprot id: A0A5F9C1D0
uniprot id: G1TEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9986:SLC12A1
gene id: 9986:SLC12A1
uniprot id: P55015
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by WNK3.
messages: Apical cell membrane
messages: Belongs to the SLC12A transporter family.
messages: Predominant in kidney. The 3 isoforms are differentially distributed within the kidney: B almost exclusively in cortex, F almost exclusively in medulla, and A about equally distributed.
messages: Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.
messages: When phosphorylated, interacts with PPP3CB.

9986:LOC100339322
gene id: 9986:LOC100339322
uniprot id: G1SLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9986:LOC100356912
gene id: 9986:LOC100356912
uniprot id: A0A5F9C6F6
uniprot id: A0A5F9CCH0
uniprot id: G1SXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9986:GHR
gene id: 9986:GHR
uniprot id: G1SVA2
uniprot id: P19941
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain (By similarity). Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation (By similarity). Interacts with ADAM17.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9986:LOC100357149
gene id: 9986:LOC100357149
uniprot id: G1U069
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345769
gene id: 9986:LOC100345769
uniprot id: G1SCX1
names: Similarity
messages: Belongs to the SMARCD family.

9986:CASP3
gene id: 9986:CASP3
uniprot id: G1SRD0
uniprot id: Q8MJC3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
messages: S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.

9986:LOC103351908
gene id: 9986:LOC103351908
uniprot id: G1TWN3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339182
gene id: 9986:LOC100339182
uniprot id: A0A5F9D1P5
uniprot id: A0A5F9DLI6
uniprot id: A0A5F9DTM6
names: Similarity
messages: Belongs to the CNKSR family.

9986:LOC100355678
gene id: 9986:LOC100355678
uniprot id: G1SFT2
names: Similarity
messages: Belongs to the CWC15 family.

9986:LOC100358646
gene id: 9986:LOC100358646
uniprot id: G1TSH7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342778
gene id: 9986:LOC100342778
uniprot id: G1TCT8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100339119
gene id: 9986:LOC100339119
uniprot id: A0A5F9CW87
names: Similarity
messages: Belongs to the thioredoxin family.

9986:PPARG
gene id: 9986:PPARG
uniprot id: Q8HXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9986:LOC100352009
gene id: 9986:LOC100352009
uniprot id: G1T4K0
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100351764
gene id: 9986:LOC100351764
uniprot id: G1TRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9986:LOC100338964
gene id: 9986:LOC100338964
uniprot id: G1THV3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100350000
gene id: 9986:LOC100350000
uniprot id: A0A5F9CK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9986:LOC100340088
gene id: 9986:LOC100340088
uniprot id: G1T4Q6
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100337988
gene id: 9986:LOC100337988
uniprot id: A0A5F9D817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

9986:LOC100342480
gene id: 9986:LOC100342480
uniprot id: G1SJI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9986:NPY6R
gene id: 9986:NPY6R
uniprot id: P79217
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in hippocampus, striatum, hypothalamus, cerebellum, small intestine, colon and adrenal gland.
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

9986:LOC100355295
gene id: 9986:LOC100355295
uniprot id: G1T2L1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9986:LOC100359235
gene id: 9986:LOC100359235
uniprot id: G1SFT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9986:STYXL2
gene id: 9986:STYXL2
uniprot id: G1U257
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9986:LOC100357742
gene id: 9986:LOC100357742
uniprot id: G1T0M8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9986:LOC100358699
gene id: 9986:LOC100358699
uniprot id: A0A5F9CS10
names: Similarity
messages: Belongs to the FGGY kinase family.

9986:ELOC
gene id: 9986:ELOC
uniprot id: A0A5F9CJC1
names: Similarity
messages: Belongs to the SKP1 family.

9986:LOC100353291
gene id: 9986:LOC100353291
uniprot id: G1SHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9986:LOC100339374
gene id: 9986:LOC100339374
uniprot id: G1SLW1
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:OLFR630
gene id: 9986:OLFR630
uniprot id: B8K189
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CTLA4
gene id: 9986:CTLA4
uniprot id: G1TDC7
uniprot id: P42072
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked. Binds to CD80/B7-1 and CD86/B7.2. Interacts with ICOSLG.
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane
messages: N-glycosylation is important for dimerization.
messages: Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.

9986:ATP2A2
gene id: 9986:ATP2A2
uniprot id: P20647
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Endoplasmic reticulum membrane
messages: Has different conformational states with differential Ca2+ affinity. The E1 conformational state (active form) shows high Ca(2+) affinity, while the E2 state exhibits low Ca(2+) affinity. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Inhibited by sarcolipin (SLN) and myoregulin (MRLN). The inhibition is blocked by VMP1 (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Stabilizes SERCA2 in its E2 state (By similarity).
messages: Interacts with TRAM2 (via C-terminus).
messages: Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity. Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1 (By similarity). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1. Interacts with TMEM203 (By similarity). Interacts with TMEM64 and PDIA3 (By similarity). Interacts with TMX2 (By similarity). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ULK1 (By similarity). Interacts with TUNAR (By similarity).
messages: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.
messages: Isoform 2 is highly expressed in heart and slow twitch skeletal muscle. Isoform 1 is widely expressed.
messages: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site on ATP2A1 that is situated between the ATP2A1 transmembrane helices.
messages: Sarcoplasmic reticulum membrane
messages: Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes.

9986:LOC100346336
gene id: 9986:LOC100346336
uniprot id: G1SVC9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346474
gene id: 9986:LOC100346474
uniprot id: A0A5F9CX76
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100341179
gene id: 9986:LOC100341179
uniprot id: G1TAS8
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9986:LOC100349026
gene id: 9986:LOC100349026
uniprot id: G1U3L8
names: Similarity
messages: Belongs to the PRR15 family.

9986:LOC100356016
gene id: 9986:LOC100356016
uniprot id: G1TFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9986:RAD51
gene id: 9986:RAD51
uniprot id: G1TCL3
uniprot id: O77507
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. Interacts with FBH1. Interacts with POLN. Interacts with RFWD3. Interacts with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA damage sites (By similarity). Component of a multiprotein complex with MEIOB and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2 (By similarity). Interacts with HELQ; stimulating HELQ DNA helic…
messages: Mitochondrion matrix
messages: Nucleus
messages: Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair.
messages: Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination.
messages: centrosome
messages: perinuclear region

9986:LOC100343389
gene id: 9986:LOC100343389
uniprot id: G1T8S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9986:LOC100353420
gene id: 9986:LOC100353420
uniprot id: U3KPJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

9986:LOC100338825
gene id: 9986:LOC100338825
uniprot id: G1SZU4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100354351
gene id: 9986:LOC100354351
uniprot id: A0A5F9CCI4
uniprot id: A0A5F9CNK4
uniprot id: A0A5F9CQ33
uniprot id: A0A5F9CSJ7
uniprot id: A0A5F9D442
uniprot id: A0A5F9DBF8
uniprot id: A0A5F9DS17
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100339586
gene id: 9986:LOC100339586
uniprot id: A0A5F9DDP9
uniprot id: G1T436
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9986:LOC100346718
gene id: 9986:LOC100346718
uniprot id: A0A654ICK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:LOC100347584
gene id: 9986:LOC100347584
uniprot id: A0A5F9C9H2
uniprot id: G1TDL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9986:RLA-A3
gene id: 9986:RLA-A3
uniprot id: Q30849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

9986:LOC100347554
gene id: 9986:LOC100347554
uniprot id: A0A5F9CHZ3
uniprot id: G1SJJ9
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9986:LOC100344063
gene id: 9986:LOC100344063
uniprot id: G1T268
names: Similarity
messages: Belongs to the CLN5 family.

9986:LOC100354838
gene id: 9986:LOC100354838
uniprot id: G1T6Y5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100352251
gene id: 9986:LOC100352251
uniprot id: A0A5F9DUV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100357933
gene id: 9986:LOC100357933
uniprot id: G1SEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC100355529
gene id: 9986:LOC100355529
uniprot id: A0A5F9CX27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9986:LOC100354130
gene id: 9986:LOC100354130
uniprot id: G1T8R1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9986:LOC100008886
gene id: 9986:LOC100008886
uniprot id: A0A5F9C2R9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9986:LOC100355818
gene id: 9986:LOC100355818
uniprot id: G1U020
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100341843
gene id: 9986:LOC100341843
uniprot id: G1U346
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

9986:LOC100354958
gene id: 9986:LOC100354958
uniprot id: G1SG58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9986:LOC103351788
gene id: 9986:LOC103351788
uniprot id: G1TPD1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100357427
gene id: 9986:LOC100357427
uniprot id: G1T072
uniprot id: G1U2N8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9986:LOC100352913
gene id: 9986:LOC100352913
uniprot id: G1U9K5
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100357166
gene id: 9986:LOC100357166
uniprot id: G1TP15
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9986:LOC100350104
gene id: 9986:LOC100350104
uniprot id: G1T8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9986:LOC100341774
gene id: 9986:LOC100341774
uniprot id: A0A5F9CLW8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100341860
gene id: 9986:LOC100341860
uniprot id: G1T0L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9986:LOC100352574
gene id: 9986:LOC100352574
uniprot id: G1U001
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9986:LOC100347684
gene id: 9986:LOC100347684
uniprot id: G1SVD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:RIGI
gene id: 9986:RIGI
uniprot id: G1SMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9986:KCNA5
gene id: 9986:KCNA5
uniprot id: P50638
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (By similarity). Interacts with UBE2I (By similarity).
messages: The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. Interacts with UBE2I.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:7556635). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:7556635). Homotetrameric channels display rapid activation and slow inactivation (PubMed:7556635). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity).

9986:CD80
gene id: 9986:CD80
uniprot id: P42070
names: Function
names: Subcellular Location Annotation
messages: Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.
messages: Membrane

9986:LOC100353849
gene id: 9986:LOC100353849
uniprot id: G1SRT4
names: Similarity
messages: Belongs to the dynein heavy chain family.

9986:LOC100354545
gene id: 9986:LOC100354545
uniprot id: G1T7B6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9986:MYLK2
gene id: 9986:MYLK2
uniprot id: P07313
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Implicated in the level of global muscle contraction and cardiac function (By similarity). Phosphorylates a specific serine in the N-terminus of a myosin light chain.
messages: May interact with centrin.

9986:CD14
gene id: 9986:CD14
uniprot id: Q28680
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPS-bound LPB. Interacts with LPAR1. Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively. Interacts with MYO18A. Interacts with FSTL1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:1375269). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted
messages: The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.

9986:LOC108176699
gene id: 9986:LOC108176699
uniprot id: G1SYB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:LOC100348842
gene id: 9986:LOC100348842
uniprot id: A0A5F9CM08
uniprot id: A0A5F9DUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9986:LOC100339065
gene id: 9986:LOC100339065
uniprot id: G1U6X6
names: Subcellular Location Annotation
messages: nucleoplasm

9986:LOC100346216
gene id: 9986:LOC100346216
uniprot id: G1TYE2
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9986:LOC100351760
gene id: 9986:LOC100351760
uniprot id: A0A5F9D9X8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:LOC100134867
gene id: 9986:LOC100134867
uniprot id: G1SNU7
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9986:LOC100349990
gene id: 9986:LOC100349990
uniprot id: G1TEV4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100341783
gene id: 9986:LOC100341783
uniprot id: G1TPF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9986:LOC100340412
gene id: 9986:LOC100340412
uniprot id: A0A5F9DHV9
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9986:LOC100349805
gene id: 9986:LOC100349805
uniprot id: G1SEL7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9986:LOC100358908
gene id: 9986:LOC100358908
uniprot id: G1SCT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:HSD11B2
gene id: 9986:HSD11B2
uniprot id: P51976
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+) (PubMed:7750480). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (By similarity). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (By similarity).
messages: Endoplasmic reticulum
messages: Highly expressed in the kidney.
messages: Inhibited by carbenoloxone.
messages: Interacts with ligand-free cytoplasmic NR3C2.
messages: Microsome

9986:LOC100355795
gene id: 9986:LOC100355795
uniprot id: G1SS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9986:LOC108177604
gene id: 9986:LOC108177604
uniprot id: G1TMR5
names: Similarity
messages: Belongs to the LCE family.

9986:LOC100356785
gene id: 9986:LOC100356785
uniprot id: G1T8A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:GPX6
gene id: 9986:GPX6
uniprot id: G1TCG2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9986:LOC100350741
gene id: 9986:LOC100350741
uniprot id: G1TB84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9986:LOC100351179
gene id: 9986:LOC100351179
uniprot id: G1TCJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9986:CYP2C2
gene id: 9986:CYP2C2
uniprot id: P00181
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9986:LOC100341967
gene id: 9986:LOC100341967
uniprot id: G1SJW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9986:LOC100354366
gene id: 9986:LOC100354366
uniprot id: G1SSN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100348114
gene id: 9986:LOC100348114
uniprot id: G1T646
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9986:PTGER4
gene id: 9986:PTGER4
uniprot id: Q28691
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly expressed in intestine, duodenal epithelium, uterus, thymus and adrenal cortex. Lower but significant expression in whole adrenal, lung, spleen, stomach, and kidney. In this latter organ, the receptor is localized in the glomeruli and the transitional epithelium of the renal calyx.
messages: Interacts with FEM1A.
messages: Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9986:LOC100342627
gene id: 9986:LOC100342627
uniprot id: G1T1F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100343044
gene id: 9986:LOC100343044
uniprot id: G1TDC1
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9986:LOC100349387
gene id: 9986:LOC100349387
uniprot id: G1TD34
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:EDN1
gene id: 9986:EDN1
uniprot id: P29560
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Secreted

9986:LOC100346879
gene id: 9986:LOC100346879
uniprot id: G1T0M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9986:LOC100341564
gene id: 9986:LOC100341564
uniprot id: A0A5F9D0D4
uniprot id: G1SYU5
names: Similarity
messages: Belongs to the RENT3 family.

9986:SLC22A1
gene id: 9986:SLC22A1
uniprot id: O77504
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Expressed in kidney, liver, and intestine.
messages: Phosphorylated.
messages: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase (PubMed:12060594, PubMed:9528667). Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity).

9986:LOC100355877
gene id: 9986:LOC100355877
uniprot id: G1T430
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9986:LOC100355126
gene id: 9986:LOC100355126
uniprot id: G1TEA0
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9986:LOC100338910
gene id: 9986:LOC100338910
uniprot id: G1T1L1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350413
gene id: 9986:LOC100350413
uniprot id: G1SND4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340091
gene id: 9986:LOC100340091
uniprot id: G1SR92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9986:LOC100359215
gene id: 9986:LOC100359215
uniprot id: G1TCX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9986:LOC100343308
gene id: 9986:LOC100343308
uniprot id: G1TDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9986:LOC100346526
gene id: 9986:LOC100346526
uniprot id: G1SUU7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9986:LOC100346397
gene id: 9986:LOC100346397
uniprot id: G1T1I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:CD59
gene id: 9986:CD59
uniprot id: O77541
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
messages: The mature form of this CD59 contains an additional serine residue before the conserved N-terminal leucine residue found in all other CD59 homologs sequenced to date.

9986:LOC100344390
gene id: 9986:LOC100344390
uniprot id: A0A5F9C7X9
uniprot id: G1SPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100345405
gene id: 9986:LOC100345405
uniprot id: G1T5J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9986:LOC100349073
gene id: 9986:LOC100349073
uniprot id: G1T0Q9
names: Subcellular Location Annotation
messages: Membrane

9986:RPL10
gene id: 9986:RPL10
uniprot id: B7NZQ2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9986:LOC100338633
gene id: 9986:LOC100338633
uniprot id: G1TEQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9986:LOC100354696
gene id: 9986:LOC100354696
uniprot id: G1TKL6
names: Similarity
messages: Belongs to the syntaxin family.

9986:CD86
gene id: 9986:CD86
uniprot id: P42071
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer. Interacts with MARCH8 (By similarity). Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40 (By similarity).
messages: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
messages: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).

9986:LOC100354052
gene id: 9986:LOC100354052
uniprot id: A0A5F9CHS0
uniprot id: A0A5F9CL65
uniprot id: A0A5F9CW09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100345455
gene id: 9986:LOC100345455
uniprot id: A0A5F9D1F2
uniprot id: A0A5F9DE02
uniprot id: G1SEM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9986:LOC100358269
gene id: 9986:LOC100358269
uniprot id: G1TE72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100345260
gene id: 9986:LOC100345260
uniprot id: G1STH9
names: Similarity
messages: Belongs to the phosducin family.

9986:LOC100342279
gene id: 9986:LOC100342279
uniprot id: G1T1H2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9986:LOC100343715
gene id: 9986:LOC100343715
uniprot id: U3KNP2
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9986:LOC100347926
gene id: 9986:LOC100347926
uniprot id: G1T542
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9986:LOC100341521
gene id: 9986:LOC100341521
uniprot id: A0A5F9D0E5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9986:POR
gene id: 9986:POR
uniprot id: P00389
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9986:LOC100359105
gene id: 9986:LOC100359105
uniprot id: G1SEB1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100350430
gene id: 9986:LOC100350430
uniprot id: G1SKF1
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100355960
gene id: 9986:LOC100355960
uniprot id: A0A5F9C8A3
names: Similarity
messages: Belongs to the CCSER family.

9986:LOC100345816
gene id: 9986:LOC100345816
uniprot id: G1T4D1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100009551
gene id: 9986:LOC100009551
uniprot id: P12337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Endoplasmic reticulum lumen
messages: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
messages: Monomer.

9986:LOC100345191
gene id: 9986:LOC100345191
uniprot id: G1TA48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9986:LOC100355593
gene id: 9986:LOC100355593
uniprot id: G1T292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9986:ADAMTS5
gene id: 9986:ADAMTS5
uniprot id: G1SIH2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100339738
gene id: 9986:LOC100339738
uniprot id: A0A5F9D0N9
uniprot id: A0A5F9DAF6
uniprot id: G1TBH5
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9986:C10H7orf25
gene id: 9986:C10H7orf25
uniprot id: G1TQ94
names: Similarity
messages: Belongs to the UPF0415 family.

9986:LOC100345758
gene id: 9986:LOC100345758
uniprot id: G1TYC0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100341505
gene id: 9986:LOC100341505
uniprot id: G1T997
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342434
gene id: 9986:LOC100342434
uniprot id: A0A5F9CN86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9986:LOC100354683
gene id: 9986:LOC100354683
uniprot id: G1T5D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9986:SEPTIN11
gene id: 9986:SEPTIN11
uniprot id: A0A5F9CB66
uniprot id: G1SF47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9986:LOC100339061
gene id: 9986:LOC100339061
uniprot id: G1TD23
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:LOC100349164
gene id: 9986:LOC100349164
uniprot id: G1SXW2
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9986:LOC100350384
gene id: 9986:LOC100350384
uniprot id: G1SIW0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100353536
gene id: 9986:LOC100353536
uniprot id: U3KMV3
uniprot id: U3KPD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9986:LOC100358881
gene id: 9986:LOC100358881
uniprot id: A0A5F9DBY6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9986:LOC100341422
gene id: 9986:LOC100341422
uniprot id: G1SGE9
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9986:LOC100348933
gene id: 9986:LOC100348933
uniprot id: G1T1J4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9986:LOC100348876
gene id: 9986:LOC100348876
uniprot id: G1TTG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347769
gene id: 9986:LOC100347769
uniprot id: A0A5F9DVA7
uniprot id: G1SWK3
uniprot id: U3KNS5
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9986:LOC100346744
gene id: 9986:LOC100346744
uniprot id: G1TDG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9986:LOC100355470
gene id: 9986:LOC100355470
uniprot id: A0A5F9DBM2
uniprot id: A0A5F9DME5
uniprot id: A0A5F9DPI9
uniprot id: A0A5F9DRV7
uniprot id: G1SKT7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100342323
gene id: 9986:LOC100342323
uniprot id: G1SQ14
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100349950
gene id: 9986:LOC100349950
uniprot id: G1TIH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9986:LOC100353260
gene id: 9986:LOC100353260
uniprot id: G1SQT9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100348744
gene id: 9986:LOC100348744
uniprot id: G1TMN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100337894
gene id: 9986:LOC100337894
uniprot id: U3KN60
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9986:LOC100353275
gene id: 9986:LOC100353275
uniprot id: G1SHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9986:LOC100353283
gene id: 9986:LOC100353283
uniprot id: G1SMI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9986:MAP3K21
gene id: 9986:MAP3K21
uniprot id: G1SZ61
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9986:LOC100340148
gene id: 9986:LOC100340148
uniprot id: A0A5F9DBC3
uniprot id: G1U3K8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100350155
gene id: 9986:LOC100350155
uniprot id: G1T1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9986:LOC100348590
gene id: 9986:LOC100348590
uniprot id: G1T2U1
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9986:LOC100355878
gene id: 9986:LOC100355878
uniprot id: A0A5F9DJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9986:LOC100352319
gene id: 9986:LOC100352319
uniprot id: A0A5F9CJ04
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100355526
gene id: 9986:LOC100355526
uniprot id: A0A5F9CDS8
uniprot id: A0A5F9CSH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9986:LOC100352250
gene id: 9986:LOC100352250
uniprot id: G1SGA1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9986:LOC100339213
gene id: 9986:LOC100339213
uniprot id: G1SMS3
names: Similarity
messages: Belongs to the actin family.

9986:PPDPFL
gene id: 9986:PPDPFL
uniprot id: U3KNQ6
names: Similarity
messages: Belongs to the PPDPF family.

9986:LOC100348126
gene id: 9986:LOC100348126
uniprot id: G1TQW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:USP14
gene id: 9986:USP14
uniprot id: P40826
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS (By similarity).
messages: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (By similarity). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (By similarity).
messages: Was originally thought to be a guanine tRNA-ribosyltransferase.

9986:LOC100340208
gene id: 9986:LOC100340208
uniprot id: G1TG76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352412
gene id: 9986:LOC100352412
uniprot id: G1SDV2
names: Subcellular Location Annotation
messages: Membrane

9986:TVP23B
gene id: 9986:TVP23B
uniprot id: A0A5F9D964
uniprot id: G1SDF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9986:GDF9
gene id: 9986:GDF9
uniprot id: A0A5F9DSD9
uniprot id: B7NZL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9986:CAMK2D
gene id: 9986:CAMK2D
uniprot id: O77708
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
messages: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity).
messages: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimu…
messages: Expressed in liver.
messages: Sarcoplasmic reticulum membrane
messages: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
messages: sarcolemma

9986:NR1H3
gene id: 9986:NR1H3
uniprot id: D5MS64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:LOC100009436
gene id: 9986:LOC100009436
uniprot id: Q29503
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Was originally thought to be UBE2R1/CDC34.
messages: When phosphorylated, interacts with beta-TrCP (BTRC).

9986:LOC100354556
gene id: 9986:LOC100354556
uniprot id: G1TIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC108176887
gene id: 9986:LOC108176887
uniprot id: G1TPV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LTA
gene id: 9986:LTA
uniprot id: A0A0U5JXZ2
uniprot id: P10154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9986:LOC100340597
gene id: 9986:LOC100340597
uniprot id: A0A5F9CIY2
uniprot id: G1SSR8
names: Similarity
messages: Belongs to the ClpX chaperone family.

9986:LOC100357370
gene id: 9986:LOC100357370
uniprot id: G1U3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357415
gene id: 9986:LOC100357415
uniprot id: A0A5F9CGL8
uniprot id: G1SGM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9986:LOC100356899
gene id: 9986:LOC100356899
uniprot id: A0A5F9CGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9986:LOC100343884
gene id: 9986:LOC100343884
uniprot id: G1T1F0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9986:LOC100350991
gene id: 9986:LOC100350991
uniprot id: G1SDL8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9986:LOC100349768
gene id: 9986:LOC100349768
uniprot id: O46373
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A4/ANT1. Interacts with ARL2BP. Interacts with TIMM44; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
messages: Under cell death induction, transglutaminated by TGM2. Transglutamination leads to formation of covalent cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming polymers.

9986:LOC100340693
gene id: 9986:LOC100340693
uniprot id: G1T9S2
names: Similarity
messages: Belongs to the intermediate filament family.

9986:CAPN3
gene id: 9986:CAPN3
uniprot id: Q9XSJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9986:LOC100340024
gene id: 9986:LOC100340024
uniprot id: G1U2P9
names: Similarity
messages: Belongs to the TCP11 family.

9986:LOC100359007
gene id: 9986:LOC100359007
uniprot id: G1SHM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9986:TMEM109
gene id: 9986:TMEM109
uniprot id: O77751
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Homooligomer (PubMed:21381722). Interacts with CRYAB (By similarity).
messages: May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (By similarity). Can form voltage-gated calcium and potassium channels in vitro (PubMed:21381722).
messages: Nucleus outer membrane
messages: Sarcoplasmic reticulum membrane
messages: The N-terminus is blocked.
messages: Widely expressed. Expressed in skeletal, cardiac and smooth muscle cells, in brain, including neuroglial cells, cerebral cortex neurons and cerebellum, but not Purkinje cells. Also detected in Paneth and Goblet cells of the small intestine (but not in the epithelium), duodenal gland, pancreas, parotid gland, testis, thyroid gland and adrenal gland, as well as in epidermis, choroid plexus, ductus epididymidis, lymphocytes, fibroblasts, endothelial cells and seminiferous epithelial cells (at protein level). Not detected in mucous cells of the duodenal gland, in hepatocytes nor in uriniferous tubules.

9986:LOC100346590
gene id: 9986:LOC100346590
uniprot id: A0A5F9DVH7
uniprot id: G1T4F3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100346468
gene id: 9986:LOC100346468
uniprot id: A0A5F9CPB0
uniprot id: A0A5F9DJH0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9986:LOC100349155
gene id: 9986:LOC100349155
uniprot id: G1SGW1
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9986:LOC100341588
gene id: 9986:LOC100341588
uniprot id: G1T2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:RAB7A
gene id: 9986:RAB7A
uniprot id: O97572
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle
messages: Endosome membrane
messages: Interacts with NTRK1/TRKA (By similarity). Interacts with RILP (By similarity). Interacts with PSMA7 (By similarity). Interacts with RNF115 (By similarity). Interacts with FYCO1 (By similarity). Interacts with the PIK3C3/VPS34-PIK3R4 complex (By similarity). The GTP-bound form interacts with OSBPL1A (By similarity). The GTP-bound form interacts with RAC1 (By similarity). Interacts with CLN3 (By similarity). Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex (By similarity). Interacts with C9orf72. Does not interact with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5 (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with RUFY4 (By similarity). Interacts with PRPH; the interaction is direct (By similarity). Interacts with VPS13A (By similarity). The GDP-bound form interacts with RIMOC1 (By similarity). Interacts with the MON1A-CCZ1B complex and this interaction is enhanced in the presence of RIMOC1 (By similarity).
messages: Late endosome membrane
messages: Lipid droplet
messages: Lysosome membrane
messages: Melanosome membrane
messages: Mitochondrion membrane
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (By similarity). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (By similarity). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway.Required for the exosomal release of SDCBP, CD63 and syndecan (By si…
messages: autophagosome membrane
messages: phagosome membrane

9986:LOC100351335
gene id: 9986:LOC100351335
uniprot id: G1TE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:ATP6V1D
gene id: 9986:ATP6V1D
uniprot id: O97755
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Membrane
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with SNX10 (By similarity).
messages: centrosome
messages: cilium
messages: clathrin-coated vesicle membrane

9986:LOC100345168
gene id: 9986:LOC100345168
uniprot id: G1TMN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100339515
gene id: 9986:LOC100339515
uniprot id: A0A5F9DFD2
uniprot id: G1TTQ4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9986:LOC100339361
gene id: 9986:LOC100339361
uniprot id: G1SKH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100347834
gene id: 9986:LOC100347834
uniprot id: G1SSB5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9986:LOC100358590
gene id: 9986:LOC100358590
uniprot id: G1TB11
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:LOC100339592
gene id: 9986:LOC100339592
uniprot id: A0A5F9DRL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:GCSH
gene id: 9986:GCSH
uniprot id: Q9N121
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity).
messages: The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH). Interacts with GLDC (By similarity).

9986:LOC100358013
gene id: 9986:LOC100358013
uniprot id: A0A5F9D3M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9986:LOC100340242
gene id: 9986:LOC100340242
uniprot id: G1TCZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9986:LOC100358335
gene id: 9986:LOC100358335
uniprot id: A0A5F9CHP6
names: Similarity
messages: Belongs to the SH3RF family.

9986:LOC100356102
gene id: 9986:LOC100356102
uniprot id: G1T8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100357849
gene id: 9986:LOC100357849
uniprot id: U3KN97
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354514
gene id: 9986:LOC100354514
uniprot id: G1TB55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9986:TUBA1B
gene id: 9986:TUBA1B
uniprot id: A0A5F9CBL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9986:LOC100338956
gene id: 9986:LOC100338956
uniprot id: G1U7Z7
names: Similarity
messages: Belongs to the peptidase S8 family.

9986:ATOSA
gene id: 9986:ATOSA
uniprot id: A0A5F9CT59
names: Similarity
messages: Belongs to the FAM214 family.

9986:OLFR604
gene id: 9986:OLFR604
uniprot id: B8K162
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SCNN1G
gene id: 9986:SCNN1G
uniprot id: Q28738
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
messages: ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. Interacts with NEDD4; via the WW domains. Interacts with NEDD4L; via the WW domains. Interacts with WWP1; via the WW domains. Interacts with WWP2; via the WW domains. Interacts with the full length immature form of PCSK9 (pro-PCSK9).
messages: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
messages: Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.

9986:LOC100338942
gene id: 9986:LOC100338942
uniprot id: G1T4F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAI family.
messages: Cytoplasm
messages: Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.
messages: Nucleus
messages: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

9986:LOC100348045
gene id: 9986:LOC100348045
uniprot id: A0A5F9CSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347716
gene id: 9986:LOC100347716
uniprot id: G1SIC8
names: Function
messages: May be involved in spermatogenesis.

9986:LOC100353331
gene id: 9986:LOC100353331
uniprot id: G1TCM3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100353678
gene id: 9986:LOC100353678
uniprot id: G1T4Q1
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9986:LOC100337980
gene id: 9986:LOC100337980
uniprot id: G1T5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9986:LOC100008927
gene id: 9986:LOC100008927
uniprot id: G1SCN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9986:LOC100357561
gene id: 9986:LOC100357561
uniprot id: A0A5F9CM57
uniprot id: G1T0M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100343927
gene id: 9986:LOC100343927
uniprot id: A0A5F9CPU1
uniprot id: A0A5F9DCM9
uniprot id: G1SES3
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9986:LOC100341170
gene id: 9986:LOC100341170
uniprot id: A0A5F9DL98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9986:LOC100344405
gene id: 9986:LOC100344405
uniprot id: A0A5F9C8Y5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100351334
gene id: 9986:LOC100351334
uniprot id: A0A5F9DS02
uniprot id: G1TI53
uniprot id: G1U2A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus

9986:LOC100338376
gene id: 9986:LOC100338376
uniprot id: A0A5F9DCM7
uniprot id: G1TXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100356207
gene id: 9986:LOC100356207
uniprot id: A0A5F9CDE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9986:LOC100349582
gene id: 9986:LOC100349582
uniprot id: G1T9D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9986:LOC100348320
gene id: 9986:LOC100348320
uniprot id: G1TCX4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9986:LOC100338512
gene id: 9986:LOC100338512
uniprot id: G1TKP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338913
gene id: 9986:LOC100338913
uniprot id: G1T7E7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (By similarity). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).

9986:LOC100353531
gene id: 9986:LOC100353531
uniprot id: A0A5F9CEZ6
uniprot id: A0A5F9D5H4
uniprot id: A0A5F9DPG0
uniprot id: G1SFS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9986:LOC100347881
gene id: 9986:LOC100347881
uniprot id: G1T7M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356478
gene id: 9986:LOC100356478
uniprot id: A0A5F9CR06
uniprot id: A0A5F9D079
uniprot id: G1SVJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9986:LOC100343802
gene id: 9986:LOC100343802
uniprot id: P11957
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
messages: Monomer.

9986:LOC100356567
gene id: 9986:LOC100356567
uniprot id: G1T2Q2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9986:LOC100349120
gene id: 9986:LOC100349120
uniprot id: G1SEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100351154
gene id: 9986:LOC100351154
uniprot id: A0A5F9D358
uniprot id: G1TIP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9986:LOC100349306
gene id: 9986:LOC100349306
uniprot id: G1SF82
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9986:IFGGA1
gene id: 9986:IFGGA1
uniprot id: G1U5V3
uniprot id: J7PDN3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9986:CALHM4
gene id: 9986:CALHM4
uniprot id: G1TF53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9986:LOC100342374
gene id: 9986:LOC100342374
uniprot id: A0A5F9D886
uniprot id: A0A5F9DD12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9986:LOC100349980
gene id: 9986:LOC100349980
uniprot id: G1TAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9986:LOC100356840
gene id: 9986:LOC100356840
uniprot id: A0A5F9C9W9
uniprot id: G1T4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9986:LOC100341716
gene id: 9986:LOC100341716
uniprot id: G1SPN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9986:LOC100351781
gene id: 9986:LOC100351781
uniprot id: G1SRM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9986:LOC100358647
gene id: 9986:LOC100358647
uniprot id: G1SCX4
names: Subcellular Location Annotation
messages: lamellipodium

9986:LOC100351480
gene id: 9986:LOC100351480
uniprot id: G1TGF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
messages: Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.
messages: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation.

9986:LOC100348539
gene id: 9986:LOC100348539
uniprot id: A0A5F9D8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350103
gene id: 9986:LOC100350103
uniprot id: G1TWZ0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100359052
gene id: 9986:LOC100359052
uniprot id: G1TN97
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100351283
gene id: 9986:LOC100351283
uniprot id: G1T633
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9986:LOC100357806
gene id: 9986:LOC100357806
uniprot id: G1TIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100343948
gene id: 9986:LOC100343948
uniprot id: A0A5F9DBS3
uniprot id: A0A5F9DDC4
uniprot id: G1TNM4
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9986:LOC100351020
gene id: 9986:LOC100351020
uniprot id: G1T0M2
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9986:LOC100342137
gene id: 9986:LOC100342137
uniprot id: G1TIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340477
gene id: 9986:LOC100340477
uniprot id: G1T680
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100350797
gene id: 9986:LOC100350797
uniprot id: G1SIJ2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9986:LOC100338247
gene id: 9986:LOC100338247
uniprot id: G1T670
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9986:LOC100351858
gene id: 9986:LOC100351858
uniprot id: G1SG22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9986:LOC100355545
gene id: 9986:LOC100355545
uniprot id: G1SE62
names: Similarity
messages: Belongs to the DNase I family.

9986:LOC100342000
gene id: 9986:LOC100342000
uniprot id: G1SQT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9986:LOC100342617
gene id: 9986:LOC100342617
uniprot id: G1T6A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9986:LOC100356429
gene id: 9986:LOC100356429
uniprot id: A0A5F9D7U0
uniprot id: G1SL01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100359143
gene id: 9986:LOC100359143
uniprot id: A0A5F9C2C5
uniprot id: A0A5F9C367
uniprot id: A0A5F9CKD7
uniprot id: A0A5F9DM95
uniprot id: G1T243
names: Similarity
messages: Belongs to the TPD52 family.

9986:PKM
gene id: 9986:PKM
uniprot id: P11974
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300, leading to impair phosphoenolpyruvate substrate-binding and promote its homodimerization and subsequent translocation to the nucleus. Deacetylation by SIRT6 promotes its nuclear export into the cytoplasm, leading to suppress its nuclear localization and oncogenic function.
messages: Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.
messages: Belongs to the pyruvate kinase family.
messages: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
messages: Cytoplasm
messages: FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.
messages: Has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
messages: ISGylated.
messages: Isoform M2 is allosterically activated by D-fructose 1,6-bisphosphate (FBP). Inhibited by oxalate and 3,3',5-triiodo-L-thyronine (T3). The activity of the tetrameric form is inhibited by PML. Selective binding to tyrosine-phosphorylated peptides releases the allosteric activator FBP, leading to inhibition of PKM enzymatic activity, this diverts glucose metabolites from energy production to anabolic processes when cells are stimulated by certain growth factors. Glycolytic flux are highly dependent on de novo biosynthesis of serine and glycine, and serine is a natural ligand and allosteric activator of isoform M2.
messages: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity. In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase. Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase. Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription. Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages. May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (By similarity).
messages: Monomer and homotetramer; exists as a monomer in the absence of D-fructose 1,6-bisphosphate (FBP), and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds 3,3',5-triiodo-L-thyronine (T3). Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. FBP stimulates the formation of tetramers from dimers. Homodimer; exists in a dimeric form in tumor cells and the dimeric form has less affinity for the phosphoenolpyruvate substrate. The homodimer converts into a protein kinase. Interacts with HERC1, POU5F1 and PML. Interacts with EGLN3; the interaction hydroxylates PKM under hypoxia and enhances binding to HIF1A. Interacts with HIF1A; the interaction is enhanced by binding of EGLN3, promoting enhanced transcription activity under hypoxia. Interacts with TRIM35; this interaction prevents FGFR1-dependent tyrosine phosphorylation. Interacts with JMJD8. Interacts with TRAF4. Interacts with (phosphorylated) CTNNB1; leading to activate transcription.
messages: Nucleus
messages: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
messages: There are 4 isozymes of pyruvate kinase in mammals (L, R, M1, M2) encoded by 2 different genes: PKLR and PKM. The L and R isozymes are generated from the PKLR by differential splicing of RNA; the M1 and M2 forms are produced from the PKM gene by differential splicing. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells.
messages: Under hypoxia, hydroxylated by EGLN3.

9986:LOC100339956
gene id: 9986:LOC100339956
uniprot id: G1U154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346132
gene id: 9986:LOC100346132
uniprot id: G1U0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347321
gene id: 9986:LOC100347321
uniprot id: G1U383
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9986:LOC100357049
gene id: 9986:LOC100357049
uniprot id: A0A5F9DJ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9986:LOC100358528
gene id: 9986:LOC100358528
uniprot id: G1SDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9986:LOC100352353
gene id: 9986:LOC100352353
uniprot id: G1TAM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9986:RPL5
gene id: 9986:RPL5
uniprot id: G1SYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9986:LOC100341600
gene id: 9986:LOC100341600
uniprot id: A0A5F9DNW8
uniprot id: G1T6M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9986:CAPZA2
gene id: 9986:CAPZA2
uniprot id: Q09YN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9986:LOC100349773
gene id: 9986:LOC100349773
uniprot id: G1TC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

9986:LOC100355523
gene id: 9986:LOC100355523
uniprot id: A0A5F9C5Z0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9986:LOC100347339
gene id: 9986:LOC100347339
uniprot id: G1STS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9986:CA12
gene id: 9986:CA12
uniprot id: A0A5F9CL84
uniprot id: Q9MZ30
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Homodimer.
messages: Inhibited by acetazolamide.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

9986:LOC100358555
gene id: 9986:LOC100358555
uniprot id: G1SFF5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9986:LOC100341523
gene id: 9986:LOC100341523
uniprot id: G1T9B5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340859
gene id: 9986:LOC100340859
uniprot id: G1SCQ3
names: Similarity
messages: Belongs to the NSRP1 family.

9986:LOC100356167
gene id: 9986:LOC100356167
uniprot id: G1T055
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CHPF
gene id: 9986:CHPF
uniprot id: B7NZH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9986:LOC100344684
gene id: 9986:LOC100344684
uniprot id: A0A5F9D9A7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

9986:LOC100342564
gene id: 9986:LOC100342564
uniprot id: A0A5F9CBB8
uniprot id: A0A5F9CNN6
uniprot id: A0A5F9CU02
uniprot id: A0A5F9DHY5
uniprot id: U3KNE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100359065
gene id: 9986:LOC100359065
uniprot id: A0A5F9C3L8
uniprot id: G1SML1
names: Subcellular Location Annotation
messages: centrosome

9986:LOC100348316
gene id: 9986:LOC100348316
uniprot id: P00939
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Asn-16 and Asn-72 undergo deamidation which gives rise to four extra negative charges. These are expected to decrease subunit-subunit interactions and so expose the hydrophobic interface to the aqueous environment.
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9986:WDR76
gene id: 9986:WDR76
uniprot id: B7NZF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9986:LOC100340272
gene id: 9986:LOC100340272
uniprot id: G1SS71
names: Subcellular Location Annotation
messages: Membrane

9986:PNPLA8
gene id: 9986:PNPLA8
uniprot id: Q5XTS1
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
messages: Calcium-independent phospholipase.
messages: Endoplasmic reticulum membrane
messages: Expressed in kidney, heart and brain.
messages: Mitochondrion membrane
messages: Peroxisome membrane

9986:LOC100357334
gene id: 9986:LOC100357334
uniprot id: G1SI36
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9986:LOC100338416
gene id: 9986:LOC100338416
uniprot id: U3KN44
names: Similarity
messages: Belongs to the LRRFIP family.

9986:LOC100346284
gene id: 9986:LOC100346284
uniprot id: G1TPE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100338478
gene id: 9986:LOC100338478
uniprot id: G1SJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:AGL
gene id: 9986:AGL
uniprot id: G1TS42
uniprot id: P35574
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Monomer. Interacts with NHLRC1/malin (By similarity).
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
messages: The N-terminus is blocked.
messages: Ubiquitinated.

9986:LOC100347336
gene id: 9986:LOC100347336
uniprot id: G1TEI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9986:LOC100344493
gene id: 9986:LOC100344493
uniprot id: A0A5F9DJI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100358598
gene id: 9986:LOC100358598
uniprot id: G1SPG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9986:OLFR68
gene id: 9986:OLFR68
uniprot id: B8K170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358519
gene id: 9986:LOC100358519
uniprot id: G1SYN7
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9986:LOC100340845
gene id: 9986:LOC100340845
uniprot id: G1SXM5
names: Similarity
messages: Belongs to the FAM229 family.

9986:LOC100340954
gene id: 9986:LOC100340954
uniprot id: G1T824
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9986:CBLIF
gene id: 9986:CBLIF
uniprot id: G1SK47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9986:LOC100346484
gene id: 9986:LOC100346484
uniprot id: G1U4T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354104
gene id: 9986:LOC100354104
uniprot id: A0A5F9CPW1
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9986:LOC100343592
gene id: 9986:LOC100343592
uniprot id: G1T932
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9986:LOC100352610
gene id: 9986:LOC100352610
uniprot id: G1TAM8
uniprot id: G1TGJ6
names: Similarity
messages: Belongs to the PA28 family.

9986:LOC100345868
gene id: 9986:LOC100345868
uniprot id: G1TLX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352820
gene id: 9986:LOC100352820
uniprot id: G1STM9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100359303
gene id: 9986:LOC100359303
uniprot id: G1T4H0
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100343983
gene id: 9986:LOC100343983
uniprot id: A0A5F9CT49
names: Subcellular Location Annotation
messages: nucleolus

9986:LOC100347824
gene id: 9986:LOC100347824
uniprot id: G1U9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9986:PGM1
gene id: 9986:PGM1
uniprot id: P00949
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Glucose-1,6-bisphosphate enhances phosphorylation of the active site Ser-117, and thereby increases enzyme activity.
messages: Isoform 2 is the major calmodulin-dependent phosphoprotein in junctional skeletal sarcoplasmic reticulum vesicles.
messages: Monomer.
messages: Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.
messages: Sarcoplasmic reticulum
messages: This enzyme participates in both the breakdown and synthesis of glucose.

9986:LOC100358525
gene id: 9986:LOC100358525
uniprot id: G1TKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100341857
gene id: 9986:LOC100341857
uniprot id: A0A5F9C1S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9986:LOC100349412
gene id: 9986:LOC100349412
uniprot id: G1T5K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC103350733
gene id: 9986:LOC103350733
uniprot id: G1U6K7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9986:LOC100343474
gene id: 9986:LOC100343474
uniprot id: G1SDC1
names: Similarity
messages: Belongs to the actin family.

9986:LOC100354835
gene id: 9986:LOC100354835
uniprot id: G1U3V0
names: Similarity
messages: Belongs to the HINT family.

9986:NAT1
gene id: 9986:NAT1
uniprot id: A0A0G2JH25
uniprot id: P18605
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arylamine N-acetyltransferase family.
messages: Cytoplasm

9986:LOC100339518
gene id: 9986:LOC100339518
uniprot id: G1TEY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100340056
gene id: 9986:LOC100340056
uniprot id: A0A5F9CT28
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9986:LOC100346509
gene id: 9986:LOC100346509
uniprot id: A0A5F9CYG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

9986:LOC100008821
gene id: 9986:LOC100008821
uniprot id: A0A5F9CUB0
uniprot id: G1SLW0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9986:LOC103349852
gene id: 9986:LOC103349852
uniprot id: G1T3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9986:LOC100350995
gene id: 9986:LOC100350995
uniprot id: G1U5U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9986:LOC100352299
gene id: 9986:LOC100352299
uniprot id: G1SHK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100358066
gene id: 9986:LOC100358066
uniprot id: G1T8Q7
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9986:LOC100343694
gene id: 9986:LOC100343694
uniprot id: G1SL36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9986:LOC100358958
gene id: 9986:LOC100358958
uniprot id: G1SSL3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9986:LOC100345659
gene id: 9986:LOC100345659
uniprot id: G1TC17
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9986:LOC100349206
gene id: 9986:LOC100349206
uniprot id: G1SN32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9986:LOC100345775
gene id: 9986:LOC100345775
uniprot id: G1SSR4
names: Similarity
messages: Belongs to the peptidase C2 family.

9986:LOC100344918
gene id: 9986:LOC100344918
uniprot id: G1SVJ4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100009572
gene id: 9986:LOC100009572
uniprot id: G1TC40
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100342375
gene id: 9986:LOC100342375
uniprot id: A0A5F9CKL2
uniprot id: A0A5F9CW99
uniprot id: A0A5F9DCB7
uniprot id: A0A5F9DJS5
uniprot id: G1U7X4
names: Similarity
messages: Belongs to the SAPAP family.

9986:LOC100352860
gene id: 9986:LOC100352860
uniprot id: G1TCG5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:LOC100354789
gene id: 9986:LOC100354789
uniprot id: G1SGJ8
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9986:LOC100347984
gene id: 9986:LOC100347984
uniprot id: G1SKV7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9986:LOC100357640
gene id: 9986:LOC100357640
uniprot id: G1SNU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9986:LOC100341706
gene id: 9986:LOC100341706
uniprot id: G1TLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9986:LOC100359252
gene id: 9986:LOC100359252
uniprot id: G1T6U6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:LOC100350571
gene id: 9986:LOC100350571
uniprot id: G1TGJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344998
gene id: 9986:LOC100344998
uniprot id: G1SNF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:LOC100338010
gene id: 9986:LOC100338010
uniprot id: A0A5F9CYN7
names: Similarity
messages: Belongs to the SCO1/2 family.

9986:LOC100339263
gene id: 9986:LOC100339263
uniprot id: G1U5T9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100354682
gene id: 9986:LOC100354682
uniprot id: A0A5F9C5A5
names: Similarity
messages: Belongs to the TTC21 family.

9986:LOC100353022
gene id: 9986:LOC100353022
uniprot id: G1SFU4
names: Similarity
messages: Belongs to the peptidase M1 family.

9986:LOC100345666
gene id: 9986:LOC100345666
uniprot id: G1SNY7
names: Similarity
messages: Belongs to the peptidase M14 family.

9986:LOC100359328
gene id: 9986:LOC100359328
uniprot id: G1SNL9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100343093
gene id: 9986:LOC100343093
uniprot id: G1TDA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344254
gene id: 9986:LOC100344254
uniprot id: A0A5F9DK95
uniprot id: G1SPI7
names: Subcellular Location Annotation
messages: trans-Golgi network

9986:LOC100345425
gene id: 9986:LOC100345425
uniprot id: G1TWR1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100337934
gene id: 9986:LOC100337934
uniprot id: G1T2R6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346980
gene id: 9986:LOC100346980
uniprot id: G1SI81
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:HOXA11
gene id: 9986:HOXA11
uniprot id: B7NZU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9986:LOC100348940
gene id: 9986:LOC100348940
uniprot id: G1TQK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9986:LOC100341249
gene id: 9986:LOC100341249
uniprot id: G1T9E7
uniprot id: U3KMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9986:LOC100008942
gene id: 9986:LOC100008942
uniprot id: G1U6S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: Secreted
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9986:TUBGCP4
gene id: 9986:TUBGCP4
uniprot id: B7NZE4
uniprot id: G1TDG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9986:LOC100338238
gene id: 9986:LOC100338238
uniprot id: G1SRB4
uniprot id: U3KMS6
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9986:LOC100009514
gene id: 9986:LOC100009514
uniprot id: G1SPK4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9986:LOC100353848
gene id: 9986:LOC100353848
uniprot id: A0A5F9CMJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9986:LOC100337966
gene id: 9986:LOC100337966
uniprot id: A0A5F9DPU5
uniprot id: G1SUH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9986:LOC100357227
gene id: 9986:LOC100357227
uniprot id: G1T285
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100349944
gene id: 9986:LOC100349944
uniprot id: G1SIN7
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9986:OR52J3
gene id: 9986:OR52J3
uniprot id: B8K159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349667
gene id: 9986:LOC100349667
uniprot id: U3KMS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:GSTM2
gene id: 9986:GSTM2
uniprot id: P46409
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Well expressed in rabbit liver, brain and kidney.

9986:LOC100338138
gene id: 9986:LOC100338138
uniprot id: G1TZV8
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9986:LOC100339133
gene id: 9986:LOC100339133
uniprot id: A0A5K1UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9986:LOC100351185
gene id: 9986:LOC100351185
uniprot id: G1U392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9986:LOC100355300
gene id: 9986:LOC100355300
uniprot id: G1TE55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100357330
gene id: 9986:LOC100357330
uniprot id: G1T6A2
names: Similarity
messages: Belongs to the CAF1 family.

9986:LOC108177369
gene id: 9986:LOC108177369
uniprot id: G1U691
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:DNAJC25
gene id: 9986:DNAJC25
uniprot id: A0A5F9CSG0
uniprot id: G1SVC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9986:LOC100355553
gene id: 9986:LOC100355553
uniprot id: G1SS66
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100338560
gene id: 9986:LOC100338560
uniprot id: G1SCP1
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9986:LOC100341366
gene id: 9986:LOC100341366
uniprot id: G1T4A4
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9986:LOC100350229
gene id: 9986:LOC100350229
uniprot id: G1TAQ4
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

9986:PMEL
gene id: 9986:PMEL
uniprot id: I4E993
names: Similarity
messages: Belongs to the PMEL/NMB family.

9986:LOC108177974
gene id: 9986:LOC108177974
uniprot id: G1SE76
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9986:RYR2
gene id: 9986:RYR2
uniprot id: Q29621
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9986:LOC100353359
gene id: 9986:LOC100353359
uniprot id: G1SUH7
names: Similarity
messages: Belongs to the LRRC42 family.

9986:LOC100346604
gene id: 9986:LOC100346604
uniprot id: G1SR66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356575
gene id: 9986:LOC100356575
uniprot id: G1TFB5
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9986:LOC100341550
gene id: 9986:LOC100341550
uniprot id: G1TNY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:USP49
gene id: 9986:USP49
uniprot id: A0A5F9DLQ9
uniprot id: B7NZK3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:LOC100340669
gene id: 9986:LOC100340669
uniprot id: G1U305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9986:LOC100356992
gene id: 9986:LOC100356992
uniprot id: G1U5H3
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9986:LOC100340489
gene id: 9986:LOC100340489
uniprot id: B7NZB2
uniprot id: G1SCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9986:LOC100009037
gene id: 9986:LOC100009037
uniprot id: G1T6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9986:LOC100349903
gene id: 9986:LOC100349903
uniprot id: A0A5F9CIN8
uniprot id: A0A5F9DD88
uniprot id: G1T0W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9986:LOC100349532
gene id: 9986:LOC100349532
uniprot id: G1SGT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9986:LOC100348266
gene id: 9986:LOC100348266
uniprot id: G1SIG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9986:LOC100356261
gene id: 9986:LOC100356261
uniprot id: G1TRI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356345
gene id: 9986:LOC100356345
uniprot id: G1TIK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9986:GNB5
gene id: 9986:GNB5
uniprot id: Q6PNB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: Component of a complex composed of RGS9, GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (By similarity). Interacts with RGS6 and RGS7 (By similarity).
messages: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).
messages: Membrane

9986:LOC100355152
gene id: 9986:LOC100355152
uniprot id: A0A5F9CFX6
names: Similarity
messages: Belongs to the NHS family.

9986:LOC100347756
gene id: 9986:LOC100347756
uniprot id: G1SEW6
names: Similarity
messages: Belongs to the NUF2 family.

9986:LOC100342613
gene id: 9986:LOC100342613
uniprot id: A0A5F9DGN2
uniprot id: G1SXK0
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9986:LOC100009548
gene id: 9986:LOC100009548
uniprot id: G1SJN7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:CYP19A1
gene id: 9986:CYP19A1
uniprot id: Q29605
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane

9986:LOC100354466
gene id: 9986:LOC100354466
uniprot id: G1SL17
names: Similarity
messages: Belongs to the peptidase M10A family.

9986:GSDME
gene id: 9986:GSDME
uniprot id: G1SRI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9986:LOC100347840
gene id: 9986:LOC100347840
uniprot id: G1TBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9986:C2H2orf68
gene id: 9986:C2H2orf68
uniprot id: G1SYH6
names: Similarity
messages: Belongs to the UPF0561 family.

9986:LOC100344328
gene id: 9986:LOC100344328
uniprot id: G1T215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9986:TP53
gene id: 9986:TP53
uniprot id: Q95330
names: Cofactor
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-380 by CREBBP enhances transcriptional activity. Acetylation of Lys-380 by EP300. Deacetylation of Lys-380 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-379 increases stability. Deacetylation at Lys-379 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-380) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces S…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-370 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-368 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-370 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-368. Dimethylated at Lys-371 by EHMT1 and EHMT2. Monomethylated at Lys-380 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-368 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-331 and dimethylated at Arg-333 and Arg-335 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter (By similarity). Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Probably phosphorylated on by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-390 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated at Ser-313 and Ser-390 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-384 by UBC9 (By similarity).
messages: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9986:LOC100343299
gene id: 9986:LOC100343299
uniprot id: P18055
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
messages: Monomer.

9986:LOC100348491
gene id: 9986:LOC100348491
uniprot id: G1SHQ7
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9986:LOC100346557
gene id: 9986:LOC100346557
uniprot id: G1T879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9986:LOC100341043
gene id: 9986:LOC100341043
uniprot id: G1U0P2
names: Similarity
messages: Belongs to the vertnin family.

9986:LOC100346706
gene id: 9986:LOC100346706
uniprot id: G1TES5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC103349694
gene id: 9986:LOC103349694
uniprot id: G1SSZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100347251
gene id: 9986:LOC100347251
uniprot id: G1U3B6
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9986:LOC100356303
gene id: 9986:LOC100356303
uniprot id: G1SGU0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9986:LOC100352143
gene id: 9986:LOC100352143
uniprot id: P50119
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity).
messages: Cytoplasm
messages: Expressed in ileum.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.
messages: Membrane

9986:SLC5A1
gene id: 9986:SLC5A1
uniprot id: P11170
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (By similarity). Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
messages: Found predominantly in intestine, renal cortex and in outer renal medulla.
messages: Mutation of Asp-28 is implicated in glucose/galactose malabsorption.
messages: N-glycosylation is not necessary for the cotransporter function.
messages: The cholesterol-binding site is formed by transmembrane helices TM1, TM7 and TM13.

9986:LOC100343390
gene id: 9986:LOC100343390
uniprot id: G1TBV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9986:LOC100353947
gene id: 9986:LOC100353947
uniprot id: G1SH72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9986:LOC100349274
gene id: 9986:LOC100349274
uniprot id: G1T5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9986:LOC100339150
gene id: 9986:LOC100339150
uniprot id: G1SZH3
names: Similarity
messages: Belongs to the serpin family.

9986:LOC100358261
gene id: 9986:LOC100358261
uniprot id: G1SX51
names: Similarity
messages: Belongs to the PRR15 family.

9986:COQ8A
gene id: 9986:COQ8A
uniprot id: G1TDF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

9986:LOC100346910
gene id: 9986:LOC100346910
uniprot id: G1SCS3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:PLP2
gene id: 9986:PLP2
uniprot id: Q95MN6
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Maximally expressed at the beginning of gastrulation.
messages: May play a role in cell differentiation in the intestinal epithelium.
messages: Membrane

9986:PTGR1
gene id: 9986:PTGR1
uniprot id: Q28719
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.
messages: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).

9986:INTS14
gene id: 9986:INTS14
uniprot id: A0A5F9CND8
uniprot id: G1ST87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9986:LOC100347744
gene id: 9986:LOC100347744
uniprot id: G1TD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100344005
gene id: 9986:LOC100344005
uniprot id: G1TK98
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9986:LOC100346531
gene id: 9986:LOC100346531
uniprot id: G1TD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9986:LOC100357079
gene id: 9986:LOC100357079
uniprot id: A0A5F9CJR1
uniprot id: G1SSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9986:LOC100352696
gene id: 9986:LOC100352696
uniprot id: A0A5F9DC47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9986:LOC100349984
gene id: 9986:LOC100349984
uniprot id: A0A5F9CRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9986:LOC100348308
gene id: 9986:LOC100348308
uniprot id: G1SZ81
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100354856
gene id: 9986:LOC100354856
uniprot id: G1SVF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9986:PSMB4
gene id: 9986:PSMB4
uniprot id: B7NZD7
uniprot id: G1T918
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9986:KCNB2
gene id: 9986:KCNB2
uniprot id: G1SIB5
uniprot id: Q95L11
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.
messages: Inhibited by quinine at micromolar levels. Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP).
messages: Membrane
messages: Perikaryon
messages: Phosphorylated.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
messages: dendrite

9986:LOC100357626
gene id: 9986:LOC100357626
uniprot id: G1SHR4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100358846
gene id: 9986:LOC100358846
uniprot id: G1T090
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100351325
gene id: 9986:LOC100351325
uniprot id: G1SCX8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9986:LOC100355530
gene id: 9986:LOC100355530
uniprot id: A0A5F9CK20
names: Similarity
messages: Belongs to the CRISP family.

9986:LOC100347923
gene id: 9986:LOC100347923
uniprot id: G1SMD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352087
gene id: 9986:LOC100352087
uniprot id: G1SRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354263
gene id: 9986:LOC100354263
uniprot id: G1U0A2
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9986:EEF1A1
gene id: 9986:EEF1A1
uniprot id: B7NZC3
uniprot id: P68105
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2.
messages: The N-terminus is blocked.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
messages: Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.
messages: nucleolus

9986:LOC100342714
gene id: 9986:LOC100342714
uniprot id: G1TXG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9986:CENPS
gene id: 9986:CENPS
uniprot id: G1TE73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9986:LOC100347399
gene id: 9986:LOC100347399
uniprot id: G1SWG3
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9986:LOC100349528
gene id: 9986:LOC100349528
uniprot id: G1T5N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9986:LOC100343722
gene id: 9986:LOC100343722
uniprot id: A0A5F9DFE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9986:LOC100340054
gene id: 9986:LOC100340054
uniprot id: A0A5F9CTH9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9986:OGN
gene id: 9986:OGN
uniprot id: Q8MJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Highly expressed in cardiac right ventricle, cardiac left ventricle, uterus and lung (at protein level). Detected at low levels in skeletal muscle, uterus, small intestine and liver (at protein level). Detected in blood vessels of kidney, pancreas, spleen and brain (at protein level). Detected in aorta and skeletal muscle.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9986:LOC100350441
gene id: 9986:LOC100350441
uniprot id: G1TCI7
names: Similarity
messages: Belongs to the synaptotagmin family.

9986:LOC100358294
gene id: 9986:LOC100358294
uniprot id: G1TU56
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100343986
gene id: 9986:LOC100343986
uniprot id: G1SKW8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9986:RIPOR2
gene id: 9986:RIPOR2
uniprot id: G1SFI8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

9986:HBG2
gene id: 9986:HBG2
uniprot id: B8K175
uniprot id: P02099
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two gamma chains.
messages: Red blood cells.
messages: This protein functions as an embryonic globin, but the gene structure and chromosomal location resemble more closely the human gamma chain gene, which codes for a fetal globin.

9986:LOC103348312
gene id: 9986:LOC103348312
uniprot id: G1SPQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9986:LOC100355449
gene id: 9986:LOC100355449
uniprot id: G1SZF6
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9986:TF
gene id: 9986:TF
uniprot id: P19134
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Expressed by the liver and secreted in plasma.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9986:LOC100339334
gene id: 9986:LOC100339334
uniprot id: G1SHM7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100346289
gene id: 9986:LOC100346289
uniprot id: G1SLM1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9986:LOC100328910
gene id: 9986:LOC100328910
uniprot id: Q08863
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Alpha family.
messages: Cytoplasm
messages: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
messages: Homodimer or heterodimer of GSTA1 and GSTA2.
messages: Liver and lung.

9986:LOC100348924
gene id: 9986:LOC100348924
uniprot id: G1SN16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9986:LOC100348753
gene id: 9986:LOC100348753
uniprot id: G1SI86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9986:LOC100337829
gene id: 9986:LOC100337829
uniprot id: G1TDR3
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

9986:SLC28A2
gene id: 9986:SLC28A2
uniprot id: Q9MZT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Cell membrane
messages: Sodium-dependent and pyrimidine-selective transporter (PubMed:11028933). Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine) (PubMed:11028933). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs (By similarity).

9986:LOC100344913
gene id: 9986:LOC100344913
uniprot id: G1TAC4
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9986:LOC100356068
gene id: 9986:LOC100356068
uniprot id: A0A0M6L0P7
uniprot id: P46407
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9986:LOC100342983
gene id: 9986:LOC100342983
uniprot id: G1ST33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9986:LOC100343732
gene id: 9986:LOC100343732
uniprot id: G1SWD6
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9986:LOC100354873
gene id: 9986:LOC100354873
uniprot id: G1SGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9986:LOC100356713
gene id: 9986:LOC100356713
uniprot id: A0A5F9CJJ7
uniprot id: A0A5F9CRD6
uniprot id: G1T795
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100346122
gene id: 9986:LOC100346122
uniprot id: G1TJ86
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100343921
gene id: 9986:LOC100343921
uniprot id: G1SRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

9986:LOC100338558
gene id: 9986:LOC100338558
uniprot id: G1SP23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9986:LOC100358786
gene id: 9986:LOC100358786
uniprot id: A0A5F9D2B3
uniprot id: A0A5F9D3E3
names: Similarity
messages: Belongs to the SS18 family.

9986:LOC100343636
gene id: 9986:LOC100343636
uniprot id: G1TEM5
names: Similarity
messages: Belongs to the dpy-30 family.

9986:LOC100353705
gene id: 9986:LOC100353705
uniprot id: G1T734
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9986:LOC100341299
gene id: 9986:LOC100341299
uniprot id: G1TVV9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342287
gene id: 9986:LOC100342287
uniprot id: G1SP32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9986:LOC103348209
gene id: 9986:LOC103348209
uniprot id: A0A5F9C3T8
uniprot id: A0A5F9DB82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:LOC100353056
gene id: 9986:LOC100353056
uniprot id: A0A5F9C7P7
uniprot id: A0A5F9DBM4
uniprot id: G1ST10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
messages: Endoplasmic reticulum

9986:LOC100347324
gene id: 9986:LOC100347324
uniprot id: G1TEG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9986:LOC100349633
gene id: 9986:LOC100349633
uniprot id: G1U666
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340336
gene id: 9986:LOC100340336
uniprot id: G1SG28
names: Similarity
messages: Belongs to the dickkopf family.

9986:LOC100344788
gene id: 9986:LOC100344788
uniprot id: G1SZD3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

9986:LOC100358689
gene id: 9986:LOC100358689
uniprot id: G1SH05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9986:LOC100343553
gene id: 9986:LOC100343553
uniprot id: G1T7N0
names: Similarity
messages: Belongs to the CCM2 family.

9986:LOC100343991
gene id: 9986:LOC100343991
uniprot id: G1U750
names: Similarity
messages: Belongs to the syntaxin family.

9986:LOC100344938
gene id: 9986:LOC100344938
uniprot id: G1SIK4
uniprot id: G1SIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9986:LOC100338535
gene id: 9986:LOC100338535
uniprot id: G1T8U7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9986:LOC100351256
gene id: 9986:LOC100351256
uniprot id: A0A5F9CTW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9986:LOC100345181
gene id: 9986:LOC100345181
uniprot id: G1SMR9
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9986:LOC103351543
gene id: 9986:LOC103351543
uniprot id: G1SHC4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9986:LOC100349730
gene id: 9986:LOC100349730
uniprot id: A0A5F9DM28
uniprot id: G1SCG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9986:JPH2
gene id: 9986:JPH2
uniprot id: Q9GKY7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with TRPC3 (By similarity). Interacts with BAG5 and HSPA8; the interaction with HSPA8 is increased in the presence of BAG5 (By similarity). Junctophilin-2 N-terminal fragment: Interacts with MEF2C (By similarity).
messages: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
messages: Nucleus
messages: Phosphorylation on Ser-165, probably by PKC, affects RYR1-mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development.
messages: Proteolytically cleaved by calpain in response to cardiac stress. The major cleavage site takes place at the C-terminus and leads to the release of the Junctophilin-2 N-terminal fragment chain (JP2NT).
messages: Sarcoplasmic reticulum membrane
messages: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids. Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3.
messages: The bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich; ARR) regions are involved in DNA-binding.
messages: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.

9986:LOC100348665
gene id: 9986:LOC100348665
uniprot id: G1SPX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9986:LOC100353673
gene id: 9986:LOC100353673
uniprot id: G1TTC7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100339504
gene id: 9986:LOC100339504
uniprot id: A0A5F9CZR3
uniprot id: G1TDT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9986:LOC100346961
gene id: 9986:LOC100346961
uniprot id: G1U6C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9986:LOC100345017
gene id: 9986:LOC100345017
uniprot id: G1TIT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9986:LOC100344785
gene id: 9986:LOC100344785
uniprot id: G1SDY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Nucleus

9986:PPP4C
gene id: 9986:PPP4C
uniprot id: P11084
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
messages: Nucleus
messages: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 and GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3 (By similarity).
messages: centrosome

9986:LOC100349658
gene id: 9986:LOC100349658
uniprot id: G1SZS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9986:LOC100343781
gene id: 9986:LOC100343781
uniprot id: G1T4R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9986:LOC100341892
gene id: 9986:LOC100341892
uniprot id: A0A5F9CJW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9986:LOC100348166
gene id: 9986:LOC100348166
uniprot id: G1TYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:OR51A7
gene id: 9986:OR51A7
uniprot id: B8K152
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100352510
gene id: 9986:LOC100352510
uniprot id: G1SFJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100340338
gene id: 9986:LOC100340338
uniprot id: G1SDI7
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9986:LOC100341192
gene id: 9986:LOC100341192
uniprot id: G1TIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100350575
gene id: 9986:LOC100350575
uniprot id: G1U6G2
names: Similarity
messages: Belongs to the HIN-200 family.

9986:GAPDH
gene id: 9986:GAPDH
uniprot id: P46406
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer (By similarity). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation.
messages: S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
messages: Sulfhydration at Cys-150 increases catalytic activity.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: cytosol

9986:LOC100351030
gene id: 9986:LOC100351030
uniprot id: G1T998
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9986:LOC100343663
gene id: 9986:LOC100343663
uniprot id: G1TXB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9986:LOC100008834
gene id: 9986:LOC100008834
uniprot id: Q8HZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9986:LOC100341754
gene id: 9986:LOC100341754
uniprot id: G1TS95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC108178683
gene id: 9986:LOC108178683
uniprot id: G1TWZ0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100341811
gene id: 9986:LOC100341811
uniprot id: U3KPI3
names: Similarity
messages: Belongs to the NSG family.

9986:LOC100347159
gene id: 9986:LOC100347159
uniprot id: A0A5F9CN00
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9986:LOC100343788
gene id: 9986:LOC100343788
uniprot id: G1SZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9986:LOC100358023
gene id: 9986:LOC100358023
uniprot id: G1SKN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9986:LOC103348469
gene id: 9986:LOC103348469
uniprot id: G1T9I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9986:LOC100009101
gene id: 9986:LOC100009101
uniprot id: G1U9R4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100338473
gene id: 9986:LOC100338473
uniprot id: A0A5F9D6F6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100343499
gene id: 9986:LOC100343499
uniprot id: G1SER9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340339
gene id: 9986:LOC100340339
uniprot id: G1STB6
names: Similarity
messages: Belongs to the actin family.

9986:LOC100358501
gene id: 9986:LOC100358501
uniprot id: G1TA04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9986:LOC100355710
gene id: 9986:LOC100355710
uniprot id: A0A5F9CR48
uniprot id: A0A5F9D271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9986:LOC100355011
gene id: 9986:LOC100355011
uniprot id: A0A5F9DDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100347873
gene id: 9986:LOC100347873
uniprot id: G1T7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346679
gene id: 9986:LOC100346679
uniprot id: U3KPN7
names: Similarity
messages: Belongs to the peptidase C48 family.

9986:LOC100343571
gene id: 9986:LOC100343571
uniprot id: A0A5F9D3N0
uniprot id: G1SFY3
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9986:LOC100353410
gene id: 9986:LOC100353410
uniprot id: A0A5F9CMD7
uniprot id: G1TBC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9986:LOC100343388
gene id: 9986:LOC100343388
uniprot id: G1TCR9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9986:LOC100345939
gene id: 9986:LOC100345939
uniprot id: G1U2Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100008716
gene id: 9986:LOC100008716
uniprot id: G1T230
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9986:LOC100344336
gene id: 9986:LOC100344336
uniprot id: A0A5F9CH27
uniprot id: G1SNH9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9986:NDEL1
gene id: 9986:NDEL1
uniprot id: O46480
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nudE family.
messages: Expressed at low levels in heart, hypothalamus, liver, lung, spleen and stomach. Expressed at higher levels in testis and brain. Within the brain, expressed in cerebellum, cerebral stem, cortex and striatum.
messages: Palmitoylation at Cys-273 reduces affinity for dynein.
messages: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE (By similarity).
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).
messages: Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, microtubules, PAFAH1B1, PCM1, PCNT, and YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts (via C-terminus) with CENPF. Interacts with ZNF365. Interacts with PLEKHM1 (via N- and C-terminus).
messages: Was originally thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle

9986:LOC100348923
gene id: 9986:LOC100348923
uniprot id: G1SIJ8
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100341590
gene id: 9986:LOC100341590
uniprot id: G1TIC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:PHAF1
gene id: 9986:PHAF1
uniprot id: G1SNC8
names: Similarity
messages: Belongs to the PHAF1 family.

9986:LOC100354170
gene id: 9986:LOC100354170
uniprot id: G1SJ19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane

9986:PTGR3
gene id: 9986:PTGR3
uniprot id: G1SUR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Cytoplasm

9986:LOC100355606
gene id: 9986:LOC100355606
uniprot id: G1T8K0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100354572
gene id: 9986:LOC100354572
uniprot id: A0A5F9CGH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9986:LOC100347656
gene id: 9986:LOC100347656
uniprot id: G1SRE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9986:LOC100344104
gene id: 9986:LOC100344104
uniprot id: G1SZ19
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9986:LOC100338966
gene id: 9986:LOC100338966
uniprot id: G1SHE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9986:LOC100344061
gene id: 9986:LOC100344061
uniprot id: A0A5F9D4D8
uniprot id: G1TBU7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9986:LOC100359188
gene id: 9986:LOC100359188
uniprot id: G1T3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100353033
gene id: 9986:LOC100353033
uniprot id: G1SQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9986:LOC103350027
gene id: 9986:LOC103350027
uniprot id: A0A5F9CIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9986:OLFR649
gene id: 9986:OLFR649
uniprot id: B8K199
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348778
gene id: 9986:LOC100348778
uniprot id: A0A5F9D311
uniprot id: G1T0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100338726
gene id: 9986:LOC100338726
uniprot id: A0A5F9CR42
uniprot id: G1TWL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357644
gene id: 9986:LOC100357644
uniprot id: G1TKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:LOC100356996
gene id: 9986:LOC100356996
uniprot id: G1T9D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9986:LOC100340446
gene id: 9986:LOC100340446
uniprot id: G1STL5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100338809
gene id: 9986:LOC100338809
uniprot id: G1TAP0
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353052
gene id: 9986:LOC100353052
uniprot id: G1T843
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9986:LOC100341758
gene id: 9986:LOC100341758
uniprot id: G1SYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9986:LOC100340631
gene id: 9986:LOC100340631
uniprot id: A0A5F9D0W1
uniprot id: G1T318
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100358081
gene id: 9986:LOC100358081
uniprot id: G1TMV1
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9986:LOC108178730
gene id: 9986:LOC108178730
uniprot id: G1TVV5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100338206
gene id: 9986:LOC100338206
uniprot id: G1U246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347835
gene id: 9986:LOC100347835
uniprot id: G1SRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100350511
gene id: 9986:LOC100350511
uniprot id: A0A5F9D4K2
names: Similarity
messages: Belongs to the calponin family.

9986:LOC100353463
gene id: 9986:LOC100353463
uniprot id: A0A5F9CS97
uniprot id: G1TAN8
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9986:LOC100355843
gene id: 9986:LOC100355843
uniprot id: G1SQW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100303763
gene id: 9986:LOC100303763
uniprot id: G1U4R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:LOC100349918
gene id: 9986:LOC100349918
uniprot id: G1T621
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:RAG2
gene id: 9986:RAG2
uniprot id: P34089
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RAG2 family.
messages: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.
messages: Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).
messages: Nucleus
messages: The atypical PHD-type zinc finger recognizes and binds histone H3 trimethylated on 'Lys-4' (H3K4me3). The presence Tyr-445 instead of a carboxylate in classical PHD-type zinc fingers results in an enhanced binding to H3K4me3 in presence of dimethylated on 'Arg-2' (H3R2me2) rather than inhibited. The atypical PHD-type zinc finger also binds various phosphoinositides, such as phosphatidylinositol 3,4-bisphosphate binding (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate binding (PtdIns(3,5)P2), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate binding (PtdIns(3,4,5)P3) (By similarity).
messages: Thymus.

9986:LOC100344355
gene id: 9986:LOC100344355
uniprot id: G1SXS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9986:LOC100353433
gene id: 9986:LOC100353433
uniprot id: G1SW59
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9986:PPP1R3A
gene id: 9986:PPP1R3A
uniprot id: Q00756
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.
messages: Membrane
messages: Phosphorylation at Ser-48 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.
messages: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).
messages: Skeletal muscle, diaphragm and cardiac muscle.
messages: The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

9986:LOC100355823
gene id: 9986:LOC100355823
uniprot id: G1SFS5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9986:LOC100338387
gene id: 9986:LOC100338387
uniprot id: G1SM35
names: Similarity
messages: Belongs to the learning-associated protein family.

9986:LOC100349434
gene id: 9986:LOC100349434
uniprot id: G1SKV4
names: Similarity
messages: Belongs to the MISS family.

9986:LOC100345451
gene id: 9986:LOC100345451
uniprot id: G1TS39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9986:LOC100009366
gene id: 9986:LOC100009366
uniprot id: G1TTQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9986:LOC100343879
gene id: 9986:LOC100343879
uniprot id: G1STE2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100349759
gene id: 9986:LOC100349759
uniprot id: G1THY5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9986:LOC100354407
gene id: 9986:LOC100354407
uniprot id: A0A5F9CQU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100351385
gene id: 9986:LOC100351385
uniprot id: G1SWH4
names: Similarity
messages: Belongs to the MS4A family.

9986:LOC100354589
gene id: 9986:LOC100354589
uniprot id: G1U127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9986:LOC100343127
gene id: 9986:LOC100343127
uniprot id: G1SDR4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355389
gene id: 9986:LOC100355389
uniprot id: G1T434
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9986:LOC100354815
gene id: 9986:LOC100354815
uniprot id: G1SXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9986:LOC100351026
gene id: 9986:LOC100351026
uniprot id: G1TCV7
names: Similarity
messages: Belongs to the AIDA family.

9986:LOC100350815
gene id: 9986:LOC100350815
uniprot id: G1SWG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9986:GJA1
gene id: 9986:GJA1
uniprot id: A0A654ICI6
uniprot id: Q6TYA7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65 (By similarity).
messages: Acetylated in the developing cortex; leading to delocalization from the cell membrane.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly (By similarity). Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity).
messages: S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.
messages: Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity).
messages: gap junction

9986:LOC100339565
gene id: 9986:LOC100339565
uniprot id: G1U511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338133
gene id: 9986:LOC100338133
uniprot id: A0A5F9D730
uniprot id: G1SEA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9986:LOC100350200
gene id: 9986:LOC100350200
uniprot id: G1SKG8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345399
gene id: 9986:LOC100345399
uniprot id: G1SL30
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9986:PHKA1
gene id: 9986:PHKA1
uniprot id: A0A5F9CGR9
uniprot id: G1U3S4
uniprot id: P18688
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: By phosphorylation of various serine residues and by calcium.
messages: Cell membrane
messages: Cys-1234 is farnesylated, but the C-terminal tripeptide is not removed and the cysteine carboxyl is not methylated.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Isoform 1 predominates in muscle, heart, brain and testis. Isoforms 1 and 2 are expressed in similar quantities in the other tissues. Isoform 3 is highly expressed in slow muscle and heart.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
messages: Phosphorylation of Ser-1018 by PKA stimulates the dephosphorylation of the beta subunit and, thus, reverses the initial stimulation of PHK by the faster beta-subunit phosphorylation by PKA, that occurs in muscle in response to adrenaline.

9986:LOC100356836
gene id: 9986:LOC100356836
uniprot id: G1T3X5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:NR1I2
gene id: 9986:NR1I2
uniprot id: Q9TU02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:ROCK1
gene id: 9986:ROCK1
uniprot id: O77819
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by RHOA binding. Inhibited by Y-27632 (By similarity).
messages: Autophosphorylated on serine and threonine residues.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing (By similarity).
messages: Cytoplasm
messages: Detected in corneal epithelium.
messages: Golgi apparatus membrane
messages: Homodimer. Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3. Interacts with FHOD1 in a Src-dependent manner. Interacts with ITGB1BP1 (via N-terminus and PTB domain). Interacts with SHROOM3 (By similarity).
messages: Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity) (PubMed:9139666). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity).
messages: The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated.
messages: bleb
messages: centriole
messages: cytoskeleton
messages: lamellipodium
messages: ruffle

9986:LOC100342802
gene id: 9986:LOC100342802
uniprot id: G1SVA6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:LOC100343672
gene id: 9986:LOC100343672
uniprot id: G1T0T2
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9986:LOC100358435
gene id: 9986:LOC100358435
uniprot id: A0A5F9CEZ2
uniprot id: A0A5F9DBN4
uniprot id: G1SLI9
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100347545
gene id: 9986:LOC100347545
uniprot id: G1SEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9986:LOC100342478
gene id: 9986:LOC100342478
uniprot id: G1SQS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9986:LOC100351595
gene id: 9986:LOC100351595
uniprot id: A0A5F9DNC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: growth cone

9986:LOC100340697
gene id: 9986:LOC100340697
uniprot id: A0A5F9DGB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100358709
gene id: 9986:LOC100358709
uniprot id: G1T628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9986:LOC100354419
gene id: 9986:LOC100354419
uniprot id: A0A5F9DR64
names: Similarity
messages: Belongs to the CBFA2T family.

9986:LOC100337912
gene id: 9986:LOC100337912
uniprot id: G1SH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9986:CACNG1
gene id: 9986:CACNG1
uniprot id: P19518
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:2158672, PubMed:12409298, PubMed:26680202, PubMed:27580036). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (PubMed:26680202, PubMed:27580036).
messages: N-glycosylated.
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: Skeletal muscle (at protein level).
messages: sarcolemma

9986:LOC100353906
gene id: 9986:LOC100353906
uniprot id: G1SET4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100357925
gene id: 9986:LOC100357925
uniprot id: G1U239
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9986:LOC100342855
gene id: 9986:LOC100342855
uniprot id: G1U2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9986:LOC100358280
gene id: 9986:LOC100358280
uniprot id: G1SKM3
names: Similarity
messages: Belongs to the GSTCD family.

9986:LOC100355404
gene id: 9986:LOC100355404
uniprot id: G1T373
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9986:LOC100354672
gene id: 9986:LOC100354672
uniprot id: G1TCQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9986:LOC100346653
gene id: 9986:LOC100346653
uniprot id: G1T652
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9986:LOC100338061
gene id: 9986:LOC100338061
uniprot id: G1T5Y5
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9986:OR51G2
gene id: 9986:OR51G2
uniprot id: B8K153
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100008781
gene id: 9986:LOC100008781
uniprot id: G1SV88
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9986:LOC100357361
gene id: 9986:LOC100357361
uniprot id: G1SYY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

9986:LOC100337726
gene id: 9986:LOC100337726
uniprot id: G1SLL8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9986:LOC100342719
gene id: 9986:LOC100342719
uniprot id: G1TSP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9986:LOC100343920
gene id: 9986:LOC100343920
uniprot id: A0A5F9CJA1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100337717
gene id: 9986:LOC100337717
uniprot id: G1TA53
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:LOC100355457
gene id: 9986:LOC100355457
uniprot id: G1T013
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9986:LOC100345001
gene id: 9986:LOC100345001
uniprot id: A0A5F9DLN8
uniprot id: G1SLG0
names: Similarity
messages: Belongs to the ANP32 family.

9986:LOC100357419
gene id: 9986:LOC100357419
uniprot id: G1SSH5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9986:LOC100338733
gene id: 9986:LOC100338733
uniprot id: G1U2U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9986:LOC100340262
gene id: 9986:LOC100340262
uniprot id: G1T0S0
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100338005
gene id: 9986:LOC100338005
uniprot id: G1T4Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9986:LOC100345047
gene id: 9986:LOC100345047
uniprot id: G1SZF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9986:LOC100338884
gene id: 9986:LOC100338884
uniprot id: G1TEQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9986:SCN9A
gene id: 9986:SCN9A
uniprot id: A0A5F9CR08
uniprot id: G1TT31
uniprot id: Q28644
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.
messages: Cell membrane
messages: Expressed in the sciatic nerve, spinal cord, brainstem, cerebellum and cortex, but not expressed in the lung, skeletal and cardiac muscles, kidney and liver.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
messages: Membrane
messages: Phosphorylation at Ser-1487 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
messages: The sodium channel complex consists of a large, channel-forming alpha subunit (SCN9A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B) (By similarity). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A (By similarity). Interacts with NEDD4 and NEDD4L (By similarity). Interacts with the conotoxin GVIIJ (By similarity).
messages: Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
messages: neuron projection

9986:LOC100351057
gene id: 9986:LOC100351057
uniprot id: G1TG58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:FAM241B
gene id: 9986:FAM241B
uniprot id: G1T896
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9986:LOC100337716
gene id: 9986:LOC100337716
uniprot id: G1U6G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348252
gene id: 9986:LOC100348252
uniprot id: G1SSL9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100348955
gene id: 9986:LOC100348955
uniprot id: G1SIZ2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9986:LOC100144341
gene id: 9986:LOC100144341
uniprot id: G1SIF2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9986:LOC100347478
gene id: 9986:LOC100347478
uniprot id: G1T4Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9986:PPP1R2
gene id: 9986:PPP1R2
uniprot id: P11845
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the protein phosphatase inhibitor 2 family.
messages: Heterodimer with PP1.
messages: Inhibitor of protein-phosphatase 1.
messages: Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex.

9986:LOC100009388
gene id: 9986:LOC100009388
uniprot id: G1SN83
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9986:LOC100351926
gene id: 9986:LOC100351926
uniprot id: A0A5F9DB83
uniprot id: G1T321
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:LOC100356108
gene id: 9986:LOC100356108
uniprot id: A0A5F9C7A4
uniprot id: A0A5F9D0G7
uniprot id: A0A5F9DAL6
uniprot id: G1SFG2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100338029
gene id: 9986:LOC100338029
uniprot id: G1TCE9
names: Subcellular Location Annotation
messages: Peroxisome

9986:LOC100008809
gene id: 9986:LOC100008809
uniprot id: G1TAH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100349071
gene id: 9986:LOC100349071
uniprot id: G1SSU9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100344394
gene id: 9986:LOC100344394
uniprot id: G1SWP7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100351313
gene id: 9986:LOC100351313
uniprot id: G1SJN8
names: Similarity
messages: Belongs to the RELT family.

9986:LOC100351645
gene id: 9986:LOC100351645
uniprot id: G1T7S2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9986:LOC100353266
gene id: 9986:LOC100353266
uniprot id: G1T8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9986:LOC100341425
gene id: 9986:LOC100341425
uniprot id: G1U5Z3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:LOC100352136
gene id: 9986:LOC100352136
uniprot id: G1U6K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345800
gene id: 9986:LOC100345800
uniprot id: A0A5F9D589
uniprot id: G1T446
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100354404
gene id: 9986:LOC100354404
uniprot id: G1SWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339697
gene id: 9986:LOC100339697
uniprot id: A0A5F9DAG7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353852
gene id: 9986:LOC100353852
uniprot id: G1SHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9986:LOC100354356
gene id: 9986:LOC100354356
uniprot id: G1TNG9
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9986:LOC100338222
gene id: 9986:LOC100338222
uniprot id: G1SLF7
names: Similarity
messages: Belongs to the mTERF family.

9986:SLC2A1
gene id: 9986:SLC2A1
uniprot id: P13355
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
messages: Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region) (By similarity). Interacts with BSG (By similarity).
messages: Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.
messages: Photoreceptor inner segment
messages: The uptake of glucose is inhibited by cytochalasin B. Glucose uptake is increased in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment: TPA-induced glucose uptake requires phosphorylation at Ser-226.

9986:TLR1
gene id: 9986:TLR1
uniprot id: G1TIU2
uniprot id: M9T155
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9986:LOC100343894
gene id: 9986:LOC100343894
uniprot id: A0A5F9DPK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9986:HOXB9
gene id: 9986:HOXB9
uniprot id: G1U843
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9986:LOC100359032
gene id: 9986:LOC100359032
uniprot id: G1SNB6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9986:LOC100353161
gene id: 9986:LOC100353161
uniprot id: A0A5F9CZ93
uniprot id: G1T5H2
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9986:LOC100338665
gene id: 9986:LOC100338665
uniprot id: G1T3S7
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9986:LOC100349485
gene id: 9986:LOC100349485
uniprot id: G1U245
names: Similarity
messages: Belongs to the peptidase M14 family.

9986:LOC100354616
gene id: 9986:LOC100354616
uniprot id: G1TBQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100341438
gene id: 9986:LOC100341438
uniprot id: A0A5F9DQ37
uniprot id: G1TB75
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346438
gene id: 9986:LOC100346438
uniprot id: G1SV55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100348157
gene id: 9986:LOC100348157
uniprot id: G1SJ71
names: Similarity
messages: Belongs to the zyg-11 family.

9986:LOC100357346
gene id: 9986:LOC100357346
uniprot id: G1T2L4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100351836
gene id: 9986:LOC100351836
uniprot id: G1SIY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9986:LOC100338321
gene id: 9986:LOC100338321
uniprot id: G1SQN7
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9986:LOC100344030
gene id: 9986:LOC100344030
uniprot id: U3KLW0
names: Similarity
messages: Belongs to the peptidase C1 family.

9986:CTSK
gene id: 9986:CTSK
uniprot id: P43236
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Predominantly expressed in osteclasts (bones).
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

9986:LOC100342482
gene id: 9986:LOC100342482
uniprot id: A0A5F9CHN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

9986:LOC100357398
gene id: 9986:LOC100357398
uniprot id: G1SM50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9986:LOC100354045
gene id: 9986:LOC100354045
uniprot id: G1T7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:LOC100351413
gene id: 9986:LOC100351413
uniprot id: G1SZB6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100349146
gene id: 9986:LOC100349146
uniprot id: F7VJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

9986:SORL1
gene id: 9986:SORL1
uniprot id: Q95209
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After maturation cleavage, interacts (via N-terminus) with its own propeptide; this interaction prevents interaction with other ligands, including CRLF1, GDNF, GFRA1, IL6 and IL6R. Interacts (via N-terminal ectodomain) with APP, forming a 1:1 stoichiometric complex; this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides. Also interacts with APP C-terminal fragment C99 and with Abeta40. Interacts with beta-secretase BACE1/BACE; this interaction may affect BACE1-binding to APP and hence reduce BACE1-dependent APP cleavage. Interacts with LRPAP1/RAP. Interacts (via C-terminal cytosolic domain) with GGA1 and GGA2 (via N-terminal VHS domain). Interacts with PACS1. May interact (via the N-terminal ectodomain) with the morphogenetic neuropeptide, also called head activator or HA; this interaction is impaired in the presence of propeptide. Interacts with neurotensin/NTS. Interacts (via the N-terminal ectodomain) with PDGFB homodimer. Interacts (via N-terminal ectodomain) with the uPA receptor PLAUR. Interacts with uPA/PLAU and PAI1/SERPINE1, either individually or in complex with each other, leading to endocytosis. Also interacts with PAI1/SERPINE1 in complex with tPA/PLAT. Interacts (via C-terminus) with AP-1 and AP-2 complexes (By similarity). Interacts with BMPR1A and BMPR1B (By similarity). Interacts with lipoprotein lipase LPL; this interaction is optimal in slightly acidic conditions. Interacts (via N-terminal ectodomain) with GDNF (via propeptide) and GDNF receptor alpha-1/GFRA1, either individually or in complex with each other. The interaction with GDNF occurs mostly intracellularly. Also interacts with other GDNF receptor alpha family members, including GFRA2, GFRA3 and GFRA4. Interacts with the insulin receptor INSR; this interaction strongly increases the surface exposure of INSR. Interacts (via cytosolic C-terminus) with STK39/SPAK. Interacts (via N-terminal ectodomain) with the heterodime…
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Expressed in brain, in particular the hippocampus, dentate gyrus, and cerebral cortex (at protein level) (PubMed:8798746). Also detected in liver, adrenal glands, pancreas and testis (PubMed:8798746). Expressed in smooth muscle cells, predominantly during proliferation (PubMed:14764453).
messages: Golgi apparatus membrane
messages: Phosphorylation at Ser-2205 facilitates the interaction with GGA1.
messages: Recycling endosome membrane
messages: Secreted
messages: Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments. Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor. Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion. Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities. Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL. Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network. Sorting receptor for the insulin receptor INSR. …
messages: Within the Golgi apparatus, the propeptide may be cleaved off by FURIN or a furin-like protease. After cleavage, the propeptide interacts with the mature protein N-terminus, preventing the association with other ligands. At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain in the extracellular milieu. The shedding may be catalyzed by ADAM17/TACE. Following shedding, PSEN1/presenilin-1 cleaves the remaining transmembrane fragment and catalyzes the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus.
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9986:CDKL2
gene id: 9986:CDKL2
uniprot id: Q9TTK0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Nucleus
messages: The [NKR]KIAxRE motif seems to be a cyclin-binding region.

9986:LOC100353030
gene id: 9986:LOC100353030
uniprot id: G1SHL3
names: Similarity
messages: Belongs to the canopy family.

9986:SLC14A2
gene id: 9986:SLC14A2
uniprot id: Q28614
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the urea transporter family.
messages: Inhibited by urea analogs and phloretin.
messages: Kidney.
messages: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.

9986:LOC100341941
gene id: 9986:LOC100341941
uniprot id: G1T359
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9986:LOC100340835
gene id: 9986:LOC100340835
uniprot id: G1SU34
names: Similarity
messages: Belongs to the SKA1 family.

9986:LOC100351666
gene id: 9986:LOC100351666
uniprot id: G1TNZ8
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9986:LOC100349794
gene id: 9986:LOC100349794
uniprot id: A0A5F9CNA2
uniprot id: A0A5F9CXJ8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9986:LOC100345103
gene id: 9986:LOC100345103
uniprot id: A0A5F9CDW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100355961
gene id: 9986:LOC100355961
uniprot id: G1T495
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: cytosol

9986:LOC100342810
gene id: 9986:LOC100342810
uniprot id: G1SRD4
names: Subcellular Location Annotation
messages: Nucleus

9986:ATP5MC3
gene id: 9986:ATP5MC3
uniprot id: G1T2R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9986:LOC100355773
gene id: 9986:LOC100355773
uniprot id: G1TMK3
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9986:LOC100346876
gene id: 9986:LOC100346876
uniprot id: A0A5F9CGY5
uniprot id: G1SRJ1
names: Similarity
messages: Belongs to the RRN3 family.

9986:LOC100340233
gene id: 9986:LOC100340233
uniprot id: A0A5F9CUQ5
uniprot id: A0A5F9CZ90
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100349583
gene id: 9986:LOC100349583
uniprot id: G1T4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9986:LOC100339663
gene id: 9986:LOC100339663
uniprot id: G1TEK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100340577
gene id: 9986:LOC100340577
uniprot id: G1TLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9986:LOC100345966
gene id: 9986:LOC100345966
uniprot id: G1TAK5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9986:LOC100344656
gene id: 9986:LOC100344656
uniprot id: G1SJ26
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100356126
gene id: 9986:LOC100356126
uniprot id: G1STD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9986:ALDOB
gene id: 9986:ALDOB
uniprot id: P79226
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7 (By similarity).
messages: In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
messages: centriolar satellite

9986:LOC100342123
gene id: 9986:LOC100342123
uniprot id: G1T2G5
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9986:LOC100353184
gene id: 9986:LOC100353184
uniprot id: G1T3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9986:LOC100354685
gene id: 9986:LOC100354685
uniprot id: G1SZR1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100345157
gene id: 9986:LOC100345157
uniprot id: A0A5F9CEY4
uniprot id: G1SFW6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100349346
gene id: 9986:LOC100349346
uniprot id: A0A5F9D4T8
uniprot id: G1SPH1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:LOC100357347
gene id: 9986:LOC100357347
uniprot id: A0A5F9D7E8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9986:LOC100355393
gene id: 9986:LOC100355393
uniprot id: G1TUW9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Mitochondrion membrane

9986:LOC100339846
gene id: 9986:LOC100339846
uniprot id: G1TJ02
names: Similarity
messages: Belongs to the SDS22 family.

9986:LOC100351056
gene id: 9986:LOC100351056
uniprot id: A0A5F9C9E4
uniprot id: A0A5F9CXN1
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100340512
gene id: 9986:LOC100340512
uniprot id: U3KPC9
names: Similarity
messages: Belongs to the cornifelin family.

9986:LOC100346726
gene id: 9986:LOC100346726
uniprot id: U3KN78
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9986:OLR1
gene id: 9986:OLR1
uniprot id: Q9XTA8
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 (By similarity).
messages: Membrane raft
messages: N-glycosylated.
messages: Overexpressed in atherosclerotic lesions.
messages: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
messages: Secreted
messages: The C-type lectin domain mediates the recognition and binding of oxLDL.
messages: The cytoplasmic region is required for subcellular sorting on the cell surface.

9986:LOC100344837
gene id: 9986:LOC100344837
uniprot id: A0A5F9D7M3
uniprot id: G1T5X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9986:LOC100357603
gene id: 9986:LOC100357603
uniprot id: A0A5F9DS40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100350238
gene id: 9986:LOC100350238
uniprot id: G1ST98
names: Subcellular Location Annotation
messages: nucleolus

9986:LOC100352174
gene id: 9986:LOC100352174
uniprot id: G1T647
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9986:LOC100008771
gene id: 9986:LOC100008771
uniprot id: A0A5F9C784
uniprot id: G1U9R2
names: Similarity
messages: Belongs to the calcitonin family.

9986:ERG28
gene id: 9986:ERG28
uniprot id: G1TBE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100358223
gene id: 9986:LOC100358223
uniprot id: G1U4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100355326
gene id: 9986:LOC100355326
uniprot id: G1SKF7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9986:LOC100346947
gene id: 9986:LOC100346947
uniprot id: G1TS89
names: Similarity
messages: Belongs to the HPF1 family.

9986:LOC100340556
gene id: 9986:LOC100340556
uniprot id: A0A5F9CXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350012
gene id: 9986:LOC100350012
uniprot id: G1TV98
names: Similarity
messages: Belongs to the popeye family.

9986:LOC100340330
gene id: 9986:LOC100340330
uniprot id: G1TAF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9986:LOC100338681
gene id: 9986:LOC100338681
uniprot id: G1SUB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LCAT
gene id: 9986:LCAT
uniprot id: P53761
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity).
messages: Detected in blood plasma (at protein level) (PubMed:8820107). Highly expressed in liver.
messages: Levels increase up to 3-fold on a 6-week cholesterol-enriched diet.
messages: Secreted

9986:LOC103348281
gene id: 9986:LOC103348281
uniprot id: G1SME8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100358174
gene id: 9986:LOC100358174
uniprot id: G1T2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342399
gene id: 9986:LOC100342399
uniprot id: G1SER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LAPTM4A
gene id: 9986:LAPTM4A
uniprot id: Q864S6
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9986:LOC100347922
gene id: 9986:LOC100347922
uniprot id: M9SZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9986:LOC100344940
gene id: 9986:LOC100344940
uniprot id: G1T8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9986:ASIC4
gene id: 9986:ASIC4
uniprot id: B7NZH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9986:LOC100101594
gene id: 9986:LOC100101594
uniprot id: G1T7L0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9986:LOC100351064
gene id: 9986:LOC100351064
uniprot id: A0A5F9CCM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9986:AHSA2P
gene id: 9986:AHSA2P
uniprot id: U3KP28
names: Similarity
messages: Belongs to the AHA1 family.

9986:LOC100338662
gene id: 9986:LOC100338662
uniprot id: G1T7P0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100351673
gene id: 9986:LOC100351673
uniprot id: G1TVT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100343558
gene id: 9986:LOC100343558
uniprot id: G1T6X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9986:PCLAF
gene id: 9986:PCLAF
uniprot id: A0A5F9CJL9
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9986:LPXN
gene id: 9986:LPXN
uniprot id: Q9N261
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with unphosphorylated ITGA4. Interacts with AR and SRF (By similarity). Interacts with PTK2B/PYK2, PTPN22 and PTPN12. Interacts (via LD motif 3) with LYN and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via LD motif 3) with PTK2/FAK (By similarity).
messages: Nucleus
messages: Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72 (By similarity).
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR (By similarity).
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling (By similarity).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9986:LOC100344253
gene id: 9986:LOC100344253
uniprot id: A0A5F9C453
uniprot id: A0A5F9DN19
uniprot id: G1STL8
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100354323
gene id: 9986:LOC100354323
uniprot id: G1TTL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9986:PLA2R1
gene id: 9986:PLA2R1
uniprot id: P49260
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
messages: Cell membrane
messages: Interacts with sPLA2-IB/PLA2G1B; this interaction mediates intracellular signaling as well as clearance of extracellular sPLA2-IB/PLA2G1B via endocytotic pathway (By similarity). Interacts with sPLA2-X/PLA2G10; this interaction mediates sPLA2-X/PLA2G10 clearance and inactivation (By similarity).
messages: Lung, skeletal muscle, brain, kidney and heart.
messages: Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.
messages: Secreted
messages: The endocytosis signal probably mediates endocytosis via clathrin-coated pits.
messages: The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing (By similarity).

9986:LOC100348052
gene id: 9986:LOC100348052
uniprot id: G1SQR7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9986:LOC100353764
gene id: 9986:LOC100353764
uniprot id: G1T107
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:CFAP298
gene id: 9986:CFAP298
uniprot id: B8K1B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9986:LOC100352279
gene id: 9986:LOC100352279
uniprot id: G1ST94
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9986:LOC100008730
gene id: 9986:LOC100008730
uniprot id: G1T8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9986:LOC100348371
gene id: 9986:LOC100348371
uniprot id: G1TG77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC103350776
gene id: 9986:LOC103350776
uniprot id: G1TZC1
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100348914
gene id: 9986:LOC100348914
uniprot id: G1SHD7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100353457
gene id: 9986:LOC100353457
uniprot id: G1STR6
names: Similarity
messages: Belongs to the DTD family.

9986:SYNJ1
gene id: 9986:SYNJ1
uniprot id: B8K1B2
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9986:LOC100338759
gene id: 9986:LOC100338759
uniprot id: A0A5F9D883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9986:LOC100352861
gene id: 9986:LOC100352861
uniprot id: G1TDG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348153
gene id: 9986:LOC100348153
uniprot id: G1SVI3
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9986:CYP4B1
gene id: 9986:CYP4B1
uniprot id: P15128
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9986:LOC100358667
gene id: 9986:LOC100358667
uniprot id: A0A5F9CJS3
uniprot id: A0A5F9D429
uniprot id: G1TVY5
names: Similarity
messages: Belongs to the beta-catenin family.

9986:LOC100356061
gene id: 9986:LOC100356061
uniprot id: G1SSD3
names: Similarity
messages: Belongs to the TPPP family.

9986:LOC100350812
gene id: 9986:LOC100350812
uniprot id: G1TNE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9986:LOC100358070
gene id: 9986:LOC100358070
uniprot id: G1SG34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9986:LOC100347064
gene id: 9986:LOC100347064
uniprot id: G1TEV3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100351656
gene id: 9986:LOC100351656
uniprot id: G1SWD4
names: Subcellular Location Annotation
messages: cilium axoneme

9986:CYP4A7
gene id: 9986:CYP4A7
uniprot id: P14581
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Liver, kidney, small intestine.
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
messages: The kidney P-450 system is rather specialized for the omega-hydroxylation of fatty acids. Both P450-KA1 and P450-KA2 catalyze the omega- and (omega-1)-hydroxylation of various fatty acids with no drug-metabolizing activity, and hydroxylate prostaglandin A1 and A2 solely at the omega-position.

9986:LOC100342441
gene id: 9986:LOC100342441
uniprot id: G1TE36
names: Similarity
messages: Belongs to the BACURD family.

9986:LOC100341616
gene id: 9986:LOC100341616
uniprot id: G1TDH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:AFF4
gene id: 9986:AFF4
uniprot id: B7NZL7
names: Similarity
messages: Belongs to the AF4 family.

9986:LOC100344401
gene id: 9986:LOC100344401
uniprot id: G1T3D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9986:LOC100351407
gene id: 9986:LOC100351407
uniprot id: G1TEH1
names: Similarity
messages: Belongs to the caprin family.

9986:LOC100341155
gene id: 9986:LOC100341155
uniprot id: G1SGX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9986:LOC100354761
gene id: 9986:LOC100354761
uniprot id: G1TPZ3
names: Similarity
messages: Belongs to the FAH family.

9986:HOXA4
gene id: 9986:HOXA4
uniprot id: B7NZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100342782
gene id: 9986:LOC100342782
uniprot id: G1SG02
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC108176524
gene id: 9986:LOC108176524
uniprot id: U3KNA5
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9986:LOC100353710
gene id: 9986:LOC100353710
uniprot id: G1TVS6
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9986:LOC100341462
gene id: 9986:LOC100341462
uniprot id: G1SRW0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9986:DRD1
gene id: 9986:DRD1
uniprot id: G1SML2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9986:LOC100343457
gene id: 9986:LOC100343457
uniprot id: G1TDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100351591
gene id: 9986:LOC100351591
uniprot id: G1TKX3
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9986:ATP12A
gene id: 9986:ATP12A
uniprot id: Q9TV52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Found in the skin, kidney, distal colon and brain. In the kidney it is found in the connecting tubule, cortical collecting duct and outer medullary collecting duct while in the brain it is specific to choroid plexus and cortex.
messages: The X(+)/K(+) ATPase pump is composed of a catalytic alpha subunit and an auxiliary non-catalytic beta subunit. The alpha subunit pairs with the beta subunit of gastric H(+)/K(+) ATPase ATP4B or the beta subunit of Na(+)/K(+) ATPases ATP1B1 and ATP1B3; this interaction is required for the formation of a functionally active pump and its targeting at the plasma membrane.
messages: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (By similarity). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity).

9986:LOC100351101
gene id: 9986:LOC100351101
uniprot id: G1U664
names: Similarity
messages: Belongs to the SPIN/STSY family.

9986:LOC100338394
gene id: 9986:LOC100338394
uniprot id: A0A5F9DH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9986:LOC100357828
gene id: 9986:LOC100357828
uniprot id: G1T802
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9986:LOC100340861
gene id: 9986:LOC100340861
uniprot id: G1SI37
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:LOC100337909
gene id: 9986:LOC100337909
uniprot id: G1TR84
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (By similarity). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).

9986:SPA17
gene id: 9986:SPA17
uniprot id: P36425
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Homodimer. May interact with ROPN1 (By similarity).
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
messages: Testis- and sperm-specific.
messages: The N-terminus is blocked.

9986:LOC100338120
gene id: 9986:LOC100338120
uniprot id: G1T5D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9986:LOC100344332
gene id: 9986:LOC100344332
uniprot id: G1SPG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100356814
gene id: 9986:LOC100356814
uniprot id: A0A5F9CY81
uniprot id: G1SX56
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9986:SGK1
gene id: 9986:SGK1
uniprot id: A0A5F9CXY9
uniprot id: Q9XT18
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1. Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1 (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression (By similarity).
messages: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphoryla…
messages: Two specific sites, one in the kinase domain (Thr-256) and the other in the C-terminal regulatory region (Ser-422), need to be phosphorylated for its full activation. Phosphorylation at Ser-397 and Ser-401 are also essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells (By similarity).

9986:LOC100354750
gene id: 9986:LOC100354750
uniprot id: A0A5F9DDX3
uniprot id: A0A5F9DJX4
names: Similarity
messages: Belongs to the DOCK family.

9986:LOC100346817
gene id: 9986:LOC100346817
uniprot id: G1SEH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9986:LOC100348932
gene id: 9986:LOC100348932
uniprot id: G1SMF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

9986:LOC100340162
gene id: 9986:LOC100340162
uniprot id: A0A5F9D5X3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100348654
gene id: 9986:LOC100348654
uniprot id: A0A5F9CK35
uniprot id: A0A5F9D9N9
names: Similarity
messages: Belongs to the FAM135 family.

9986:LOC100351172
gene id: 9986:LOC100351172
uniprot id: G1SML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9986:SPR
gene id: 9986:SPR
uniprot id: A0A0D3RIF6
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9986:LOC100352512
gene id: 9986:LOC100352512
uniprot id: G1SDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9986:LOC100355688
gene id: 9986:LOC100355688
uniprot id: G1SZM3
names: Similarity
messages: Belongs to the CBP3 family.

9986:LOC100355304
gene id: 9986:LOC100355304
uniprot id: G1SPT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9986:LOC100337913
gene id: 9986:LOC100337913
uniprot id: A0A5F9CV75
uniprot id: A0A5F9DMR5
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9986:LOC100339283
gene id: 9986:LOC100339283
uniprot id: A0A5F9CBH1
uniprot id: G1SJF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9986:LOC100356789
gene id: 9986:LOC100356789
uniprot id: G1T2M5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340475
gene id: 9986:LOC100340475
uniprot id: A0A5F9C552
uniprot id: A0A5F9DBL5
uniprot id: G1SJJ8
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9986:HPRT1
gene id: 9986:HPRT1
uniprot id: A7X8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
messages: Cytoplasm
messages: Homotetramer.

9986:RYR3
gene id: 9986:RYR3
uniprot id: G1T1E2
uniprot id: Q9TS33
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily.
messages: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity.
messages: Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg(2+) and ruthenium red.
messages: Detected in skeletal muscle from young rabbits and in adult diaphragm muscle (at protein level). Detected in brain, especially in corpus striatum, thalamus and hippocampus. Detected in taenia coli, uterus, vas deferens, aorta, stomach, small intestine, heart, diaphragm and ureter. Isoform 2 is highly expressed in uterus and aorta, and at much lower levels in heart, brain and diaphragm.
messages: Homotetramer. Isoform 2 can form tetramers with isoform 1. Heterotetramer with RYR2. Interacts with FKBP1A. Interacts with CALM. Interacts with SELENON (PubMed:18713863).
messages: Lacks a predicted transmembrane segment and does not form functional calcium channels.
messages: Membrane
messages: Microsome membrane
messages: Sarcoplasmic reticulum
messages: Sarcoplasmic reticulum membrane
messages: The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
messages: Ubiquitous in skeletal muscle in neonates and in 15 day old rabbits. In adult, detected in diaphragm muscle, and in a subset of skeletal muscles including digastricus, pterygoideus, tongue and masseter.

9986:LOC100343440
gene id: 9986:LOC100343440
uniprot id: G1SRS8
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9986:LOC100343752
gene id: 9986:LOC100343752
uniprot id: A0A5F9DLC8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9986:LOC100339712
gene id: 9986:LOC100339712
uniprot id: A0A5F9CFG4
uniprot id: A0A5F9CIY9
uniprot id: A0A5F9DKG4
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100350075
gene id: 9986:LOC100350075
uniprot id: G1SKU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9986:LOC100338432
gene id: 9986:LOC100338432
uniprot id: G1TKJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100357340
gene id: 9986:LOC100357340
uniprot id: G1TM27
names: Similarity
messages: Belongs to the SERF family.

9986:LOC100347730
gene id: 9986:LOC100347730
uniprot id: G1TJC6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9986:KEF51 p09
gene id: 9986:KEF51_p09
uniprot id: A0A3S8V6S2
uniprot id: O79431
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9986:LOC100009382
gene id: 9986:LOC100009382
uniprot id: A0A5F9CEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341346
gene id: 9986:LOC100341346
uniprot id: G1TET0
names: Similarity
messages: Belongs to the peptidase M14 family.

9986:LOC100345709
gene id: 9986:LOC100345709
uniprot id: G1T2J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9986:LOC100345872
gene id: 9986:LOC100345872
uniprot id: G1SFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9986:LOC100337880
gene id: 9986:LOC100337880
uniprot id: G1SJY0
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9986:LOC100008618
gene id: 9986:LOC100008618
uniprot id: A0A5F9CY66
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9986:INHA
gene id: 9986:INHA
uniprot id: B7NZH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9986:VDAC1
gene id: 9986:VDAC1
uniprot id: Q9TT15
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
messages: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells.
messages: Homodimer and homotrimer; in response to cyclic AMP or calcium. Interacts with hexokinases including HK1. The HK1-VDAC1 complex interacts with ATF2. Interacts with BCL2L1. Interacts with BAK1. Interacts with RTL10/BOP (via BH3 domain). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation. Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF. Interacts with SPG7, NIPSNAP2 and SLC25A30. Interacts with TMEM41B. Interacts with BCAP31.
messages: Inhibited by nitric oxide.
messages: Membrane raft
messages: Mitochondrion outer membrane
messages: Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation.
messages: Ubiquitinated. Undergoes monoubiquitination and polyubiquitination by PRKN; monoubiquitination at Lys-274 inhibits apoptosis, whereas polyubiquitination leads to its degradation and promotes mitophagy. Deubiquitinated by USP30.

9986:LOC100349754
gene id: 9986:LOC100349754
uniprot id: A0A5F9CVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9986:LOC100357840
gene id: 9986:LOC100357840
uniprot id: G1TY21
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100337824
gene id: 9986:LOC100337824
uniprot id: G1SKJ4
names: Subcellular Location Annotation
messages: Mitochondrion

9986:LOC100346971
gene id: 9986:LOC100346971
uniprot id: A0A5F9CLS6
uniprot id: G1SLB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9986:LOC100349263
gene id: 9986:LOC100349263
uniprot id: A0A2D1PJJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9986:LOC100356201
gene id: 9986:LOC100356201
uniprot id: G1SRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9986:LOC100009563
gene id: 9986:LOC100009563
uniprot id: G1TU01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9986:LOC100351770
gene id: 9986:LOC100351770
uniprot id: G1SNP5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC108178711
gene id: 9986:LOC108178711
uniprot id: G1SYU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9986:H1-4
gene id: 9986:H1-4
uniprot id: A0A5S8HLQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9986:LOC100339959
gene id: 9986:LOC100339959
uniprot id: G1SV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9986:LOC100343197
gene id: 9986:LOC100343197
uniprot id: G1TT80
names: Similarity
messages: Belongs to the FAM228 family.

9986:LOC100349822
gene id: 9986:LOC100349822
uniprot id: G1SFZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9986:LOC100353163
gene id: 9986:LOC100353163
uniprot id: G1SUE5
uniprot id: G1U3R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100342314
gene id: 9986:LOC100342314
uniprot id: A0A5F9DA90
uniprot id: A0A5F9DA99
uniprot id: A0A5F9DIG8
uniprot id: A0A5F9DPI8
uniprot id: A0A5F9DTF0
uniprot id: G1TX63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9986:LOC100358460
gene id: 9986:LOC100358460
uniprot id: A0A5F9D688
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9986:LOC100338367
gene id: 9986:LOC100338367
uniprot id: A0A5K1UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9986:LOC100342758
gene id: 9986:LOC100342758
uniprot id: G1TC12
names: Similarity
messages: Belongs to the FAM221 family.

9986:LOC100349219
gene id: 9986:LOC100349219
uniprot id: A0A5F9C7V9
names: Subcellular Location Annotation
messages: PML body

9986:LOC100338761
gene id: 9986:LOC100338761
uniprot id: G1SSB8
names: Similarity
messages: Belongs to the EAF family.

9986:LOC103344950
gene id: 9986:LOC103344950
uniprot id: G1SEP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350039
gene id: 9986:LOC100350039
uniprot id: G1SQ09
names: Subcellular Location Annotation
messages: Cell membrane

9986:LOC100344739
gene id: 9986:LOC100344739
uniprot id: G1SNG3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9986:LOC100353039
gene id: 9986:LOC100353039
uniprot id: G1SXD2
names: Similarity
messages: Belongs to the popeye family.

9986:LOC100347680
gene id: 9986:LOC100347680
uniprot id: G1T0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356727
gene id: 9986:LOC100356727
uniprot id: A0A5F9CTZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100358603
gene id: 9986:LOC100358603
uniprot id: G1U8F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9986:ATP5F1A
gene id: 9986:ATP5F1A
uniprot id: G1SKT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9986:LOC100357159
gene id: 9986:LOC100357159
uniprot id: G1T4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:LOC100357913
gene id: 9986:LOC100357913
uniprot id: A0A5F9CLR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100346601
gene id: 9986:LOC100346601
uniprot id: G1TKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347649
gene id: 9986:LOC100347649
uniprot id: G1TU03
names: Similarity
messages: Belongs to the RANBP9/10 family.

9986:LOC100352906
gene id: 9986:LOC100352906
uniprot id: G1SCR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9986:LOC100341747
gene id: 9986:LOC100341747
uniprot id: G1T718
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100348376
gene id: 9986:LOC100348376
uniprot id: G1SGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:APOBEC1
gene id: 9986:APOBEC1
uniprot id: P47855
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 Zn(2+) ion per subunit.
messages: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
messages: Cytoplasm
messages: Expressed exclusively in the intestine.
messages: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Interacts with HNRPAB and SYNCRIP.

9986:LOC100341683
gene id: 9986:LOC100341683
uniprot id: G1TY99
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9986:LOC100348511
gene id: 9986:LOC100348511
uniprot id: G1TPV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9986:LOC100338175
gene id: 9986:LOC100338175
uniprot id: A0A5F9CIG8
uniprot id: A0A5F9DIK2
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9986:LOC103348081
gene id: 9986:LOC103348081
uniprot id: A0A5F9D9T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100345109
gene id: 9986:LOC100345109
uniprot id: A0A5F9CJH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9986:CAVIN3
gene id: 9986:CAVIN3
uniprot id: G1STU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9986:LOC100356360
gene id: 9986:LOC100356360
uniprot id: G1T0Z8
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9986:LOC100346544
gene id: 9986:LOC100346544
uniprot id: G1SLV1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100338523
gene id: 9986:LOC100338523
uniprot id: G1SUY2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9986:LOC100341036
gene id: 9986:LOC100341036
uniprot id: G1TT25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:KAP6.1.1
gene id: 9986:KAP6.1.1
uniprot id: C1J961
names: Similarity
messages: Belongs to the KRTAP type 6 family.

9986:LOC100341185
gene id: 9986:LOC100341185
uniprot id: G1SP19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9986:LARK
gene id: 9986:LARK
uniprot id: Q9BDY9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Interacts with TNPO3; the interaction mediates nuclear import of the protein and is disrupted by nuclear Ran bound to GTP. Interacts with EIF4G1 and WT1. Interacts with EIF4A1; the interaction is modulated under stress-induced conditions. Interacts with AGO1. Interacts with AGO2; the interaction occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with DDX5; the interaction occurs in an RNA-independent manner (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylated. Phosphorylated in vitro on Ser-304 by SRPK1. Phosphorylation on Ser-304 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation. Phosphorylation on Ser-304 is induced upon cell muscle differentiation (By similarity).
messages: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity).
messages: nucleolus

9986:PPP1CC
gene id: 9986:PPP1CC
uniprot id: G1SWW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9986:LOC100351725
gene id: 9986:LOC100351725
uniprot id: A0A5F9DFJ3
uniprot id: G1TJ93
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9986:LOC100340388
gene id: 9986:LOC100340388
uniprot id: G1TK14
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9986:LOC100343893
gene id: 9986:LOC100343893
uniprot id: G1SHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100356357
gene id: 9986:LOC100356357
uniprot id: A0A5F9D3W3
uniprot id: G1SYK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100008765
gene id: 9986:LOC100008765
uniprot id: G1T5I4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100343645
gene id: 9986:LOC100343645
uniprot id: G1T5D3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9986:OR51I1
gene id: 9986:OR51I1
uniprot id: B8K184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355369
gene id: 9986:LOC100355369
uniprot id: A0A5F9C2K4
uniprot id: A0A5F9DP96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9986:LOC100346784
gene id: 9986:LOC100346784
uniprot id: A0A5F9DJD7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9986:OR52E1
gene id: 9986:OR52E1
uniprot id: B8K158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338152
gene id: 9986:LOC100338152
uniprot id: A0A5F9CSY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9986:LOC100348628
gene id: 9986:LOC100348628
uniprot id: G1TSH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356066
gene id: 9986:LOC100356066
uniprot id: G1TNP4
names: Similarity
messages: Belongs to the LovG family.

9986:LOC100337892
gene id: 9986:LOC100337892
uniprot id: G1U642
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9986:LOC100347639
gene id: 9986:LOC100347639
uniprot id: G1TUG7
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9986:LOC100347401
gene id: 9986:LOC100347401
uniprot id: G1SNN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9986:LOC100343198
gene id: 9986:LOC100343198
uniprot id: A0A5F9C7T5
uniprot id: A0A5F9DG59
uniprot id: A0A5F9DMX8
uniprot id: G1SW93
names: Similarity
messages: Belongs to the RRM CPEB family.

9986:TMED7
gene id: 9986:TMED7
uniprot id: G1T0B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9986:LOC100342221
gene id: 9986:LOC100342221
uniprot id: A0A5F9CC22
uniprot id: A0A5F9CKS8
uniprot id: G1SYX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:CA2
gene id: 9986:CA2
uniprot id: P00919
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Essential for bone resorption and osteoclast differentiation. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
messages: Cell membrane
messages: Cytoplasm
messages: Inhibited by acetazolamide.
messages: Interacts with SLC4A4 and SLC26A6. Interaction with SLC4A7 regulates SLC4A7 transporter activity (By similarity).

9986:LOC103348701
gene id: 9986:LOC103348701
uniprot id: A0A5F9DHU9
uniprot id: A0A5F9DUP2
uniprot id: G1TWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9986:LOC100351141
gene id: 9986:LOC100351141
uniprot id: G1SLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9986:LOC100346655
gene id: 9986:LOC100346655
uniprot id: G1TH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100348362
gene id: 9986:LOC100348362
uniprot id: G1SFK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9986:LOC100339971
gene id: 9986:LOC100339971
uniprot id: G1T4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9986:LOC100359042
gene id: 9986:LOC100359042
uniprot id: G1U437
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9986:LOC100355861
gene id: 9986:LOC100355861
uniprot id: G1SDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

9986:LOC100341430
gene id: 9986:LOC100341430
uniprot id: G1T562
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9986:PAX3
gene id: 9986:PAX3
uniprot id: G1TDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9986:LOC100351063
gene id: 9986:LOC100351063
uniprot id: G1SK56
names: Similarity
messages: Belongs to the peptidase M67C family.

9986:LOC100344156
gene id: 9986:LOC100344156
uniprot id: G1U7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9986:LOC100340496
gene id: 9986:LOC100340496
uniprot id: G1STX1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:CFTR
gene id: 9986:CFTR
uniprot id: Q00554
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Isoform 1 is expressed in the pancreas. Isoform 2 is specifically expressed in the ventricle.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9986:LOC100340517
gene id: 9986:LOC100340517
uniprot id: G1T0Q4
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9986:LOC100339497
gene id: 9986:LOC100339497
uniprot id: G1SHL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9986:LOC100008852
gene id: 9986:LOC100008852
uniprot id: G1SPD7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100352483
gene id: 9986:LOC100352483
uniprot id: G1TY35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100349181
gene id: 9986:LOC100349181
uniprot id: A0A5F9CSN6
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9986:LOC100346996
gene id: 9986:LOC100346996
uniprot id: G1TFE8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9986:LOC100354596
gene id: 9986:LOC100354596
uniprot id: G1SH30
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9986:LOC100343964
gene id: 9986:LOC100343964
uniprot id: P02624
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
messages: This parvalbumin has an isoelectric point of 5.50.

9986:PPIA
gene id: 9986:PPIA
uniprot id: Q9TTC6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: Secreted

9986:LOC100352473
gene id: 9986:LOC100352473
uniprot id: G1T9Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9986:ETS1
gene id: 9986:ETS1
uniprot id: Q6Q428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100353045
gene id: 9986:LOC100353045
uniprot id: G1T011
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9986:LOC100350481
gene id: 9986:LOC100350481
uniprot id: G1SHW8
uniprot id: G1SR38
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100349946
gene id: 9986:LOC100349946
uniprot id: A0A5F9CVS1
names: Similarity
messages: Belongs to the NEMF family.

9986:ATP1B3
gene id: 9986:ATP1B3
uniprot id: Q9GLC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Melanosome
messages: The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic alpha subunit ATP12A.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity).

9986:LOC100347819
gene id: 9986:LOC100347819
uniprot id: A0A5F9CX14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9986:ORYCUNV1R1587
gene id: 9986:ORYCUNV1R1587
uniprot id: G1TEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358979
gene id: 9986:LOC100358979
uniprot id: G1U771
names: Subunit
messages: Interacts with hair keratins.

9986:LOC100344505
gene id: 9986:LOC100344505
uniprot id: G1STT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9986:LOC100341484
gene id: 9986:LOC100341484
uniprot id: A0A5F9CIP8
uniprot id: G1SLR4
names: Subcellular Location Annotation
messages: tight junction

9986:LOC100351011
gene id: 9986:LOC100351011
uniprot id: G1SWE8
names: Similarity
messages: Belongs to the CNKSR family.

9986:PIGR
gene id: 9986:PIGR
uniprot id: P01832
names: Domain
names: Function
names: PTM
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR). Free secretory component interacts with bacterial antigens toxA of C. difficile and eae of E. coli.
messages: Interacts (mainly via CDR1-like domain) with dimeric IgA. Interacts (mainly via CDR2-like domain) with pentameric IgM.
messages: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
messages: N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
messages: Secreted
messages: The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.
messages: Three allotypes are known: allotype T61, allotype T62 and allotype T63. The sequence shown is that of allotype T62.
messages: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.

9986:LOC100350718
gene id: 9986:LOC100350718
uniprot id: G1SS93
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100008630
gene id: 9986:LOC100008630
uniprot id: G1SVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9986:LOC100344046
gene id: 9986:LOC100344046
uniprot id: A0A5F9C6F5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355117
gene id: 9986:LOC100355117
uniprot id: G1SLS3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9986:LOC100341940
gene id: 9986:LOC100341940
uniprot id: G1TRC1
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9986:LOC100358249
gene id: 9986:LOC100358249
uniprot id: G1SL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9986:LOC108177607
gene id: 9986:LOC108177607
uniprot id: A0A5F9C262
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

9986:CLDN1
gene id: 9986:CLDN1
uniprot id: A0ST56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9986:LOC100340557
gene id: 9986:LOC100340557
uniprot id: A0A5F9D7Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345856
gene id: 9986:LOC100345856
uniprot id: A0A5F9CT91
uniprot id: G1TU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9986:RLN1
gene id: 9986:RLN1
uniprot id: P51456
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: During squamous cell differentiation. Repressed by retinoic acid.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

9986:LOC100341022
gene id: 9986:LOC100341022
uniprot id: G1T120
names: Subcellular Location Annotation
messages: Mitochondrion

9986:LOC100352376
gene id: 9986:LOC100352376
uniprot id: G1U524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355363
gene id: 9986:LOC100355363
uniprot id: G1T8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9986:LDAF1
gene id: 9986:LDAF1
uniprot id: G1SY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9986:LOC100351809
gene id: 9986:LOC100351809
uniprot id: A0A5F9C2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344496
gene id: 9986:LOC100344496
uniprot id: G1SZC2
names: Subcellular Location Annotation
messages: Membrane

9986:LOC103349475
gene id: 9986:LOC103349475
uniprot id: A0A5F9CFB8
names: Similarity
messages: Belongs to the FAM133 family.

9986:LOC100356141
gene id: 9986:LOC100356141
uniprot id: G1U6B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

9986:LOC100352479
gene id: 9986:LOC100352479
uniprot id: A0A5F9DGX4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100351308
gene id: 9986:LOC100351308
uniprot id: G1T7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9986:SLC4A3
gene id: 9986:SLC4A3
uniprot id: O18917
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane.

9986:LOC100351270
gene id: 9986:LOC100351270
uniprot id: A0A5F9C545
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100356397
gene id: 9986:LOC100356397
uniprot id: G1SPS5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9986:LOC100358429
gene id: 9986:LOC100358429
uniprot id: G1SMV9
names: Similarity
messages: Belongs to the CoA-transferase III family.

9986:LOC100354377
gene id: 9986:LOC100354377
uniprot id: G1TS51
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

9986:LOC100348396
gene id: 9986:LOC100348396
uniprot id: G1SY53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9986:LOC100338804
gene id: 9986:LOC100338804
uniprot id: G1SYS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9986:LOC100338314
gene id: 9986:LOC100338314
uniprot id: G1SCF6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:LOC100346465
gene id: 9986:LOC100346465
uniprot id: G1TCN9
names: Similarity
messages: Belongs to the popeye family.

9986:LOC100341347
gene id: 9986:LOC100341347
uniprot id: G1SQ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100351896
gene id: 9986:LOC100351896
uniprot id: G1SKH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9986:LOC100354055
gene id: 9986:LOC100354055
uniprot id: G1SQL1
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100341527
gene id: 9986:LOC100341527
uniprot id: G1SXC7
names: Subunit
messages: Homodimer.

9986:ADAM6A
gene id: 9986:ADAM6A
uniprot id: O19051
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100354863
gene id: 9986:LOC100354863
uniprot id: G1SMZ3
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100352229
gene id: 9986:LOC100352229
uniprot id: G1TFC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CXCL8
gene id: 9986:CXCL8
uniprot id: P19874
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9986:LOC100357114
gene id: 9986:LOC100357114
uniprot id: G1SZS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339725
gene id: 9986:LOC100339725
uniprot id: G1SG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9986:LOC103350017
gene id: 9986:LOC103350017
uniprot id: G1U6T0
names: Similarity
messages: Belongs to the multicopper oxidase family.

9986:LOC100357926
gene id: 9986:LOC100357926
uniprot id: G1T8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9986:LOC100345780
gene id: 9986:LOC100345780
uniprot id: G1T5G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

9986:LOC100355929
gene id: 9986:LOC100355929
uniprot id: G1SZN6
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:LOC100345698
gene id: 9986:LOC100345698
uniprot id: G1TKE4
names: Similarity
messages: Belongs to the transferrin family.

9986:AGTR1
gene id: 9986:AGTR1
uniprot id: G1U5W9
uniprot id: P34976
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9986:LOC100341807
gene id: 9986:LOC100341807
uniprot id: A0A5F9CDV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9986:C1H11orf68
gene id: 9986:C1H11orf68
uniprot id: G1T0B0
names: Similarity
messages: Belongs to the UPF0696 family.

9986:LOC100351946
gene id: 9986:LOC100351946
uniprot id: G1SPF1
names: Similarity
messages: Belongs to the RRP12 family.

9986:LOC100350106
gene id: 9986:LOC100350106
uniprot id: G1SLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9986:LOC100338345
gene id: 9986:LOC100338345
uniprot id: G1TWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9986:LOC100348845
gene id: 9986:LOC100348845
uniprot id: A0A5F9C167
uniprot id: A0A5F9CTR8
uniprot id: A0A5F9DAJ9
uniprot id: G1TER0
uniprot id: G1TI68
names: Similarity
messages: Belongs to the SEC3 family.

9986:ORYCUNV1R1525
gene id: 9986:ORYCUNV1R1525
uniprot id: A0A5F9CBJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344155
gene id: 9986:LOC100344155
uniprot id: G1SNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9986:LOC100342288
gene id: 9986:LOC100342288
uniprot id: G1T7G3
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100345295
gene id: 9986:LOC100345295
uniprot id: A0A5F9CZM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:LOC100345922
gene id: 9986:LOC100345922
uniprot id: A0A5F9DVL2
uniprot id: G1SV36
names: Similarity
messages: Belongs to the FAM53 family.

9986:LOC100344051
gene id: 9986:LOC100344051
uniprot id: G1TMF0
names: Similarity
messages: Belongs to the FAM110 family.

9986:LOC100348091
gene id: 9986:LOC100348091
uniprot id: G1T714
names: Similarity
messages: Belongs to the TACO1 family.

9986:LOC100339771
gene id: 9986:LOC100339771
uniprot id: G1U0M9
names: Similarity
messages: Belongs to the FAM133 family.

9986:LOC100101603
gene id: 9986:LOC100101603
uniprot id: G1TEU2
names: Similarity
messages: Belongs to the peptidase M10A family.

9986:LOC100008920
gene id: 9986:LOC100008920
uniprot id: A0A5F9C9H4
uniprot id: A0A5F9CXD6
uniprot id: A0A5F9CZ72
uniprot id: A0A5F9D5U4
uniprot id: A0A5F9DCB2
uniprot id: G1SPS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9986:LOC100352428
gene id: 9986:LOC100352428
uniprot id: A0A5F9DBA0
uniprot id: G1SKV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9986:LOC100340518
gene id: 9986:LOC100340518
uniprot id: A0A5F9CTD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353350
gene id: 9986:LOC100353350
uniprot id: G1T2Z6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:LOC100342964
gene id: 9986:LOC100342964
uniprot id: G1TAE7
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:MMUT
gene id: 9986:MMUT
uniprot id: G1SQB1
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9986:LOC100343026
gene id: 9986:LOC100343026
uniprot id: G1TL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:PRKCE
gene id: 9986:PRKCE
uniprot id: P10830
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynapti…
messages: Cell membrane
messages: Cytoplasm
messages: Forms a ternary complex with TRIM63 and RACK1/GN2BL1 (By similarity). Can form a complex with PDLIM5 and N-type calcium channel (By similarity). Interacts with COPB1 (By similarity). Interacts with DGKQ (By similarity). Interacts with STAT3 (By similarity). Interacts with YWHAB (By similarity). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (By similarity). Interacts (via phorbol-ester/DAG-type 2 domain) with PRPH and VIM (By similarity). Interacts with NLRP5/MATER (By similarity).
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-565 (activation loop of the kinase domain), Thr-709 (turn motif) and Ser-728 (hydrophobic region), need to be phosphorylated for its full activation.
messages: Nucleus
messages: Phosphorylation on Thr-565 by PDPK1 triggers autophosphorylation on Ser-728. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB (By similarity).
messages: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
messages: cytoskeleton
messages: perinuclear region

9986:LOC100339165
gene id: 9986:LOC100339165
uniprot id: G1SUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100344081
gene id: 9986:LOC100344081
uniprot id: G1SGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9986:LOC100346561
gene id: 9986:LOC100346561
uniprot id: G1T847
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9986:LOC100344127
gene id: 9986:LOC100344127
uniprot id: G1TIC4
names: Similarity
messages: Belongs to the dynein heavy chain family.

9986:LOC100009482
gene id: 9986:LOC100009482
uniprot id: U3KN91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:HOXA2
gene id: 9986:HOXA2
uniprot id: B7NZT2
names: Subcellular Location Annotation
messages: Nucleus

9986:SLC6A12
gene id: 9986:SLC6A12
uniprot id: P48055
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity).

9986:LOC100347343
gene id: 9986:LOC100347343
uniprot id: G1T4W4
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100353106
gene id: 9986:LOC100353106
uniprot id: G1SPU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:TENT5A
gene id: 9986:TENT5A
uniprot id: G1SVW8
names: Similarity
messages: Belongs to the TENT family.

9986:LOC100352684
gene id: 9986:LOC100352684
uniprot id: G1SM49
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9986:LOC100349119
gene id: 9986:LOC100349119
uniprot id: A0A5F9D071
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9986:LOC100358441
gene id: 9986:LOC100358441
uniprot id: G1SJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9986:LOC100356863
gene id: 9986:LOC100356863
uniprot id: G1SZ87
names: Similarity
messages: Belongs to the SAP30 family.

9986:LOC100348217
gene id: 9986:LOC100348217
uniprot id: G1U6F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100347752
gene id: 9986:LOC100347752
uniprot id: G1TBG5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9986:LOC100349507
gene id: 9986:LOC100349507
uniprot id: G1SHQ9
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9986:LOC103351195
gene id: 9986:LOC103351195
uniprot id: A0A5F9CMZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100346051
gene id: 9986:LOC100346051
uniprot id: G1TA62
names: Similarity
messages: Belongs to the peptidase C85 family.

9986:BMP4
gene id: 9986:BMP4
uniprot id: G1T0L5
names: Similarity
messages: Belongs to the TGF-beta family.

9986:LOC100355442
gene id: 9986:LOC100355442
uniprot id: G1T9A0
names: Similarity
messages: Belongs to the FAM83 family.

9986:MLN
gene id: 9986:MLN
uniprot id: P27114
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9986:LOC127482597
gene id: 9986:LOC127482597
uniprot id: G1TTL5
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9986:LOC100343058
gene id: 9986:LOC100343058
uniprot id: G1SLA5
names: Subcellular Location Annotation
messages: Mitochondrion

9986:LOC100353934
gene id: 9986:LOC100353934
uniprot id: G1U4C0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9986:LOC100354601
gene id: 9986:LOC100354601
uniprot id: G1SGC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9986:LOC100352018
gene id: 9986:LOC100352018
uniprot id: G1SYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9986:LOC100349823
gene id: 9986:LOC100349823
uniprot id: A0A5F9CSL1
uniprot id: G1TEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9986:TNFSF10
gene id: 9986:TNFSF10
uniprot id: G1T884
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9986:LOC100352391
gene id: 9986:LOC100352391
uniprot id: A0A5F9CDT1
uniprot id: A0A5F9D8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

9986:LOC100341874
gene id: 9986:LOC100341874
uniprot id: G1SWV1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100359028
gene id: 9986:LOC100359028
uniprot id: A0A5F9D9Z9
uniprot id: G1T237
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100340433
gene id: 9986:LOC100340433
uniprot id: G1SXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9986:STAG2
gene id: 9986:STAG2
uniprot id: A0A5F9DH30
uniprot id: B7NZG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9986:LOC100343287
gene id: 9986:LOC100343287
uniprot id: G1T0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

9986:LOC100358965
gene id: 9986:LOC100358965
uniprot id: A0A5F9CDX0
uniprot id: G1TBV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9986:BPNT2
gene id: 9986:BPNT2
uniprot id: G1SLS8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9986:LOC103348513
gene id: 9986:LOC103348513
uniprot id: G1TR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9986:LOC100353810
gene id: 9986:LOC100353810
uniprot id: G1T897
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9986:LOC100358850
gene id: 9986:LOC100358850
uniprot id: G1SVU4
names: Similarity
messages: Belongs to the CKAP2 family.

9986:LOC100350972
gene id: 9986:LOC100350972
uniprot id: G1SZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338146
gene id: 9986:LOC100338146
uniprot id: A0A5F9DAW5
names: Similarity
messages: Belongs to the BIVM family.

9986:LOC100353325
gene id: 9986:LOC100353325
uniprot id: A0A5F9C7S2
uniprot id: A0A5F9CYF5
uniprot id: G1TEM8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355863
gene id: 9986:LOC100355863
uniprot id: G1U8N2
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9986:LOC100342397
gene id: 9986:LOC100342397
uniprot id: G1SCS1
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9986:LOC100354960
gene id: 9986:LOC100354960
uniprot id: G1SQ61
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100356972
gene id: 9986:LOC100356972
uniprot id: G1T2G1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100343250
gene id: 9986:LOC100343250
uniprot id: G1SPE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

9986:LOC100343397
gene id: 9986:LOC100343397
uniprot id: G1T8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9986:LOC100350750
gene id: 9986:LOC100350750
uniprot id: G1T8N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:TPM2
gene id: 9986:TPM2
uniprot id: A0A068BCW7
uniprot id: A0A068BGJ4
uniprot id: A0A5F9CAW5
uniprot id: P58776
uniprot id: Q95JE9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9986:LOC100351251
gene id: 9986:LOC100351251
uniprot id: G1SCL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9986:LOC100344685
gene id: 9986:LOC100344685
uniprot id: G1TBE8
names: Similarity
messages: Belongs to the ABI family.

9986:LOC100352774
gene id: 9986:LOC100352774
uniprot id: G1TCI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9986:LOC103345015
gene id: 9986:LOC103345015
uniprot id: G1TNU4
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9986:LOC100343495
gene id: 9986:LOC100343495
uniprot id: U3KPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9986:LOC100346250
gene id: 9986:LOC100346250
uniprot id: G1TSS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

9986:LOC100346274
gene id: 9986:LOC100346274
uniprot id: G1TLG5
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9986:LOC100347411
gene id: 9986:LOC100347411
uniprot id: G1SJ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9986:PMP2
gene id: 9986:PMP2
uniprot id: P02691
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).
messages: Monomer.
messages: P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

9986:LOC100342904
gene id: 9986:LOC100342904
uniprot id: G1TED6
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9986:LOC100134865
gene id: 9986:LOC100134865
uniprot id: A0A5F9C2I2
uniprot id: A0A5F9CMA3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100359109
gene id: 9986:LOC100359109
uniprot id: A0A5F9CJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9986:LOC100348678
gene id: 9986:LOC100348678
uniprot id: G1TBS9
names: Similarity
messages: Belongs to the WAPL family.

9986:LOC100356128
gene id: 9986:LOC100356128
uniprot id: G1T0G0
names: Similarity
messages: Belongs to the leprecan family.

9986:LOC100341799
gene id: 9986:LOC100341799
uniprot id: G1T1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9986:LOC100351569
gene id: 9986:LOC100351569
uniprot id: G1SPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
messages: Nucleus
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.

9986:LOC100339825
gene id: 9986:LOC100339825
uniprot id: A0A5F9CW22
uniprot id: G1SLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9986:LOC100339300
gene id: 9986:LOC100339300
uniprot id: G1TDV8
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9986:LOC100348800
gene id: 9986:LOC100348800
uniprot id: G1TV04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9986:LOC100340383
gene id: 9986:LOC100340383
uniprot id: G1SSZ9
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9986:TFEB
gene id: 9986:TFEB
uniprot id: B7NZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9986:KEF51 p12
gene id: 9986:KEF51_p12
uniprot id: A0A3S8V6Y1
uniprot id: O79428
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100343888
gene id: 9986:LOC100343888
uniprot id: A0A5F9C586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9986:LOC100341336
gene id: 9986:LOC100341336
uniprot id: G1TAZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9986:LOC100348181
gene id: 9986:LOC100348181
uniprot id: G1SIM6
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9986:LOC100355798
gene id: 9986:LOC100355798
uniprot id: G1T1J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9986:LOC100343486
gene id: 9986:LOC100343486
uniprot id: G1T1R5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9986:LOC100343849
gene id: 9986:LOC100343849
uniprot id: G1TLK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:TNFAIP6
gene id: 9986:TNFAIP6
uniprot id: P98065
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By serum and growth factors.
messages: Fetal skeletal muscle, esophagus, kidney, and lung.
messages: Interacts (via Link domain) with inter-alpha-inhibitor (I-alpha-I) component bikunin. Interacts with ITIH2/HC2; this interaction is required for transesterification of the HC to hyaluronan. Interacts (via Link and CUB domains) with ITIH1. Chondroitin sulfate may be required for the stability of the complex. Interacts (via Link domain) with various C-X-C and C-C chemokines including PF4, CXCL8, CXCL11, CXCL12, CCL2, CCL7, CCL19, CCL21, and CCL27; this interaction interferes with chemokine binding to glycosaminoglycans. Interacts (primarily via Link domain) with BMP2; this interaction is inhibited by hyaluronan. Interacts (via both Link and CUB domains) with TNFSF11. Interacts (via CUB domain) with FN1 (via type III repeats 9-14); this interaction enhances fibronectin fibril assembly. TNFAIP6 may act as a bridging molecule between FN1 and THBS1.
messages: Major regulator of extracellular matrix organization during tissue remodeling (By similarity). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (By similarity). Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (By similarity). Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (By similarity). Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation. In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (By similarity). Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts. Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (By similarity).
messages: Secreted
messages: The CUB domain is necessary for calcium ion binding and transesterification reaction. It is required for binding to FN1.
messages: The Link domain interacts with various extracellular matrix components, including heparin, heparan sulfates, hyaluronan and I-alpha-I complex. It is required for binding to various chemokines.
messages: Vascular smooth muscle cells.

9986:LOC100348989
gene id: 9986:LOC100348989
uniprot id: G1SK04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9986:LOC100340012
gene id: 9986:LOC100340012
uniprot id: G1TWJ4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9986:LOC100346688
gene id: 9986:LOC100346688
uniprot id: G1SFP0
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9986:LOC100352093
gene id: 9986:LOC100352093
uniprot id: A0A5F9CD27
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9986:LOC100342903
gene id: 9986:LOC100342903
uniprot id: G1SPZ9
names: Similarity
messages: Belongs to the PPase family.

9986:LOC100339342
gene id: 9986:LOC100339342
uniprot id: G1SG39
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100352615
gene id: 9986:LOC100352615
uniprot id: A0A5F9DDV3
uniprot id: G1T752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9986:LOC100356034
gene id: 9986:LOC100356034
uniprot id: G1SU90
names: Similarity
messages: Belongs to the ZNF277 family.

9986:LOC100009518
gene id: 9986:LOC100009518
uniprot id: A0A5F9D0K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9986:SLC5A11
gene id: 9986:SLC5A11
uniprot id: Q28728
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Expressed in brain, lung and kidney. In the kidney, strongly expressed in the cortex, at the luminal side of proximal convoluted tubules and in BBMVs. Weaker expression observed in the medulla (at protein level).
messages: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:12133831, PubMed:15181167, PubMed:17932225, PubMed:15613375). Exhibits stereospecific cotransport of both D-glucose and D-xylose (PubMed:12133831). May induce apoptosis through the TNF-alpha, PDCD1 pathway (By similarity). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (PubMed:17306760).
messages: MI transport activity stimulated five-fold under 24 hour hypertonic shock conditions. MI inward currents were gradually inhibited as increasing amounts of phlorizin were added to the superfusion medium. When sodium is replaced by potassium, MI uptake is dramatically reduced and in the presence of L-fucose or D-chiro-inositol (DCI), the specific accumulation of tracer amounts of MI is also reduced.
messages: Membrane

9986:LOC100349783
gene id: 9986:LOC100349783
uniprot id: G1SX89
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9986:SERPINB11
gene id: 9986:SERPINB11
uniprot id: B7NZ97
uniprot id: G1SWM4
names: Similarity
messages: Belongs to the serpin family.

9986:LOC100350755
gene id: 9986:LOC100350755
uniprot id: G1T5D2
names: Similarity
messages: Belongs to the HEBP family.

9986:LOC100346660
gene id: 9986:LOC100346660
uniprot id: G1TD22
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100346106
gene id: 9986:LOC100346106
uniprot id: A0A5F9DH93
uniprot id: G1SYP2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100338486
gene id: 9986:LOC100338486
uniprot id: G1T2D0
names: Similarity
messages: Belongs to the FAM124 family.

9986:LOC100342838
gene id: 9986:LOC100342838
uniprot id: G1SS70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9986:LOC100354962
gene id: 9986:LOC100354962
uniprot id: A0A5F9C3D9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100349567
gene id: 9986:LOC100349567
uniprot id: G1SNQ5
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9986:LOC100357812
gene id: 9986:LOC100357812
uniprot id: G1SI21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100351599
gene id: 9986:LOC100351599
uniprot id: G1SPF7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:LOC100340438
gene id: 9986:LOC100340438
uniprot id: G1TFJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC108177401
gene id: 9986:LOC108177401
uniprot id: U3KMS0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100341787
gene id: 9986:LOC100341787
uniprot id: G1T516
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9986:LOC100339786
gene id: 9986:LOC100339786
uniprot id: G1SM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9986:LOC100340503
gene id: 9986:LOC100340503
uniprot id: G1TTE8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9986:LOC100338242
gene id: 9986:LOC100338242
uniprot id: A0A5F9DJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9986:CACNB2
gene id: 9986:CACNB2
uniprot id: A0A5F9D9E5
uniprot id: P54288
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel beta subunit family.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:15134636). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity). Interacts with CACNA1C (PubMed:22649239). Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Interacts with TMIGD2 (By similarity). Interacts with CAMK2D. Interacts with CBARP (By similarity). Interacts with CAMK2A (By similarity).
messages: Predominantly expressed in heart, aorta and brain.
messages: Regulated through phosphorylation at Thr-526 by CaMK2D.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9986:LOC100358220
gene id: 9986:LOC100358220
uniprot id: G1T676
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100345214
gene id: 9986:LOC100345214
uniprot id: G1SSC9
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100343786
gene id: 9986:LOC100343786
uniprot id: G1U8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349428
gene id: 9986:LOC100349428
uniprot id: A0A5F9CKS0
names: Similarity
messages: Belongs to the COX20 family.

9986:LOC100009230
gene id: 9986:LOC100009230
uniprot id: G1TKC9
names: Subcellular Location Annotation
messages: extracellular matrix

9986:LOC100356548
gene id: 9986:LOC100356548
uniprot id: G1TYT3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

9986:LOC100348781
gene id: 9986:LOC100348781
uniprot id: G1TQN1
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100350017
gene id: 9986:LOC100350017
uniprot id: G1T9B2
names: Similarity
messages: Belongs to the mab-21 family.

9986:INMT
gene id: 9986:INMT
uniprot id: O97972
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity).
messages: Cytoplasm
messages: Highly expressed in lung, also detected in liver and at very low levels in brain.
messages: Monomer.

9986:LOC100343201
gene id: 9986:LOC100343201
uniprot id: G1SLN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:XDH
gene id: 9986:XDH
uniprot id: A9YL93
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer. Interacts with BTN1A1.
messages: Peroxisome

9986:LOC100339242
gene id: 9986:LOC100339242
uniprot id: G1T1I1
names: Similarity
messages: Belongs to the UPP synthase family.

9986:LOC100347809
gene id: 9986:LOC100347809
uniprot id: A0A5F9CED2
uniprot id: A0A5F9DE76
uniprot id: A0A5F9DMR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9986:SELL
gene id: 9986:SELL
uniprot id: Q28629
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100352441
gene id: 9986:LOC100352441
uniprot id: G1T1A3
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9986:LOC100345694
gene id: 9986:LOC100345694
uniprot id: G1TZ76
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:OLFR561
gene id: 9986:OLFR561
uniprot id: B8K142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100009350
gene id: 9986:LOC100009350
uniprot id: G1T3Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9986:KARS1
gene id: 9986:KARS1
uniprot id: A0A5F9C713
uniprot id: G1TKC4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9986:LOC100357971
gene id: 9986:LOC100357971
uniprot id: G1T972
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9986:LOC100342253
gene id: 9986:LOC100342253
uniprot id: G1U8J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358716
gene id: 9986:LOC100358716
uniprot id: G1SVU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9986:TMEM198
gene id: 9986:TMEM198
uniprot id: B7NZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9986:ATP1B2
gene id: 9986:ATP1B2
uniprot id: Q8WMG3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with BSG (By similarity).
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity).

9986:FOXL2
gene id: 9986:FOXL2
uniprot id: Q6VFT5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ESR1. Interacts with UBE2I/UBC9. Interacts with SMAD3. Interacts with DDX20.
messages: Nucleus
messages: Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
messages: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a regulator of CYP19 expression (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity).

9986:LOC100346740
gene id: 9986:LOC100346740
uniprot id: G1STI8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:ORYCUNV1R1543
gene id: 9986:ORYCUNV1R1543
uniprot id: A0A5F9DJJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338211
gene id: 9986:LOC100338211
uniprot id: G1TEN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9986:LOC100341752
gene id: 9986:LOC100341752
uniprot id: G1TV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344985
gene id: 9986:LOC100344985
uniprot id: G1T3U1
names: Similarity
messages: Belongs to the GORASP family.

9986:LOC100356056
gene id: 9986:LOC100356056
uniprot id: G1TL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353370
gene id: 9986:LOC100353370
uniprot id: G1T919
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9986:LOC100347485
gene id: 9986:LOC100347485
uniprot id: A0A5F9CZY2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

9986:LOC100342103
gene id: 9986:LOC100342103
uniprot id: G1U6R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:NASP
gene id: 9986:NASP
uniprot id: A0A5F9CE49
uniprot id: G1U8I5
uniprot id: P27123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NASP family.
messages: Binds to linker H1 histones but not to core histones (By similarity). Interacts with histones H2A, H2B, H3 and H4 (By similarity). Interacts with histone H3.3 (By similarity). Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to H1-6/H1T (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
messages: Testis- and sperm-specific.

9986:LOC100347418
gene id: 9986:LOC100347418
uniprot id: G1SRW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100358677
gene id: 9986:LOC100358677
uniprot id: G1SIV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9986:LOC100339176
gene id: 9986:LOC100339176
uniprot id: A0A5F9D3X4
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9986:LOC100338081
gene id: 9986:LOC100338081
uniprot id: G1T4H0
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100352133
gene id: 9986:LOC100352133
uniprot id: G1T3K6
names: Similarity
messages: Belongs to the MS4A family.

9986:LOC108178552
gene id: 9986:LOC108178552
uniprot id: G1TBE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

9986:CSN1S2A
gene id: 9986:CSN1S2A
uniprot id: P50418
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9986:LOC100338429
gene id: 9986:LOC100338429
uniprot id: G1SNE1
names: Similarity
messages: Belongs to the nucleoredoxin family.

9986:LOC100350761
gene id: 9986:LOC100350761
uniprot id: G1SEW4
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9986:PEBP1
gene id: 9986:PEBP1
uniprot id: Q8MK67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).
messages: Cytoplasm
messages: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
messages: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity).

9986:LOC100349716
gene id: 9986:LOC100349716
uniprot id: G1TKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9986:LOC100352599
gene id: 9986:LOC100352599
uniprot id: G1TSE7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100351254
gene id: 9986:LOC100351254
uniprot id: A0A5F9C3L4
uniprot id: A0A5F9D0F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9986:LOC100359233
gene id: 9986:LOC100359233
uniprot id: G1SDI9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9986:LOC100339540
gene id: 9986:LOC100339540
uniprot id: G1SQA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350992
gene id: 9986:LOC100350992
uniprot id: G1TLM7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:LOC100356538
gene id: 9986:LOC100356538
uniprot id: G1SVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9986:LOC100354265
gene id: 9986:LOC100354265
uniprot id: G1SHQ6
names: Similarity
messages: Belongs to the synuclein family.

9986:LOC100344665
gene id: 9986:LOC100344665
uniprot id: G1TL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100359193
gene id: 9986:LOC100359193
uniprot id: G1U8E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338576
gene id: 9986:LOC100338576
uniprot id: G1SZT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9986:LOC100357165
gene id: 9986:LOC100357165
uniprot id: G1T0G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:H3-3A
gene id: 9986:H3-3A
uniprot id: P84246
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed throughout the cell cycle independently of DNA synthesis.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity).
messages: Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9986:ACAP2
gene id: 9986:ACAP2
uniprot id: G1SG54
uniprot id: Q6IVG4
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9986:GARS1
gene id: 9986:GARS1
uniprot id: G1SNM1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9986:LOC100351558
gene id: 9986:LOC100351558
uniprot id: A0A5F9DB46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9986:CDH16
gene id: 9986:CDH16
uniprot id: Q28634
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: Kidney specific. Limited to the basolateral membranes of renal tubular epithelial cells.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9986:NPY
gene id: 9986:NPY
uniprot id: B6VRS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9986:LOC100349895
gene id: 9986:LOC100349895
uniprot id: G1U3N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:UBE2B
gene id: 9986:UBE2B
uniprot id: P63148
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cell membrane
messages: Interacts with RAD18, UBR2 and WAC.
messages: Nucleus

9986:LOC100350189
gene id: 9986:LOC100350189
uniprot id: G1U827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357639
gene id: 9986:LOC100357639
uniprot id: A0A5F9DKS1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9986:LOC100341208
gene id: 9986:LOC100341208
uniprot id: G1SRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9986:LOC100344221
gene id: 9986:LOC100344221
uniprot id: G1SH10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9986:LOC100341923
gene id: 9986:LOC100341923
uniprot id: G1STI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9986:LOC100357881
gene id: 9986:LOC100357881
uniprot id: G1T9K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100338248
gene id: 9986:LOC100338248
uniprot id: G1SP28
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339185
gene id: 9986:LOC100339185
uniprot id: G1SIT5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9986:LOC100344606
gene id: 9986:LOC100344606
uniprot id: G1U829
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342908
gene id: 9986:LOC100342908
uniprot id: G1SJT0
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9986:LOC100348576
gene id: 9986:LOC100348576
uniprot id: A0A5F9C6E8
uniprot id: G1SVI0
names: Similarity
messages: Belongs to the DEAD box helicase family.

9986:LOC100343385
gene id: 9986:LOC100343385
uniprot id: A0A5F9CW97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9986:LOC100341854
gene id: 9986:LOC100341854
uniprot id: A0A5F9CTU2
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9986:LOC100338587
gene id: 9986:LOC100338587
uniprot id: A0A5F9CYI6
uniprot id: G1SY54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9986:LOC100341086
gene id: 9986:LOC100341086
uniprot id: G1STV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9986:LOC108177295
gene id: 9986:LOC108177295
uniprot id: G1SJW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9986:LOC100346022
gene id: 9986:LOC100346022
uniprot id: A0A5F9D0K1
uniprot id: A0A5F9DAD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9986:LOC100346712
gene id: 9986:LOC100346712
uniprot id: G1SYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9986:CRYBA2
gene id: 9986:CRYBA2
uniprot id: A4L9I9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9986:LOC100350736
gene id: 9986:LOC100350736
uniprot id: G1SDK9
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100344732
gene id: 9986:LOC100344732
uniprot id: G1SN61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9986:LOC100343785
gene id: 9986:LOC100343785
uniprot id: G1TN83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338178
gene id: 9986:LOC100338178
uniprot id: A0A5F9DCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9986:LOC100340993
gene id: 9986:LOC100340993
uniprot id: G1SU91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9986:LOC100352582
gene id: 9986:LOC100352582
uniprot id: G1SMP0
names: Similarity
messages: Belongs to the BRAG family.

9986:LOC100342831
gene id: 9986:LOC100342831
uniprot id: A0A5F9CS18
uniprot id: G1SDT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9986:OSBP
gene id: 9986:OSBP
uniprot id: P16258
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer or homotrimer. Interacts (via FFAT motif) with VAPA. Interacts (via C-terminus) with RELCH (via the third HEAT repeat) (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity).
messages: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:18165705). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (By similarity). Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity).
messages: The FFAT motif is required for interaction with VATA and proper localization of the protein.
messages: The N-terminus is blocked.
messages: The PH and the Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
messages: The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
messages: cytosol
messages: perinuclear region

9986:SEC63
gene id: 9986:SEC63
uniprot id: B7NZG4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100347237
gene id: 9986:LOC100347237
uniprot id: G1SFU7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9986:LOC100353675
gene id: 9986:LOC100353675
uniprot id: A0A5F9CFH0
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9986:LOC100341079
gene id: 9986:LOC100341079
uniprot id: G1SE80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9986:LOC100358108
gene id: 9986:LOC100358108
uniprot id: G1U3W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:CELF3
gene id: 9986:CELF3
uniprot id: B7NZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100359187
gene id: 9986:LOC100359187
uniprot id: G1U341
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344746
gene id: 9986:LOC100344746
uniprot id: A0A5F9CZ39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC108176002
gene id: 9986:LOC108176002
uniprot id: G1T0W0
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9986:LOC100358169
gene id: 9986:LOC100358169
uniprot id: A0A5F9CKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9986:LOC100355796
gene id: 9986:LOC100355796
uniprot id: A0A5F9DW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9986:LOC100358176
gene id: 9986:LOC100358176
uniprot id: G1SL99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9986:LOC100355533
gene id: 9986:LOC100355533
uniprot id: G1SRM0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9986:LOC100340903
gene id: 9986:LOC100340903
uniprot id: G1T1H6
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9986:IL15
gene id: 9986:IL15
uniprot id: Q2PUG6
uniprot id: Q3Y5G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
messages: Expressed in many tissues including heart, spleen, lung, liver, muscle and kidney (at mRNA level). Expressed in many tissues including heart, spleen, lung, liver, muscle and kidney (at protein level).
messages: Secreted

9986:LOC100344079
gene id: 9986:LOC100344079
uniprot id: A0A5F9CAW0
uniprot id: G1TAD0
names: Similarity
messages: Belongs to the DPH3 family.

9986:H2AZ2
gene id: 9986:H2AZ2
uniprot id: O62695
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ2 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

9986:LOC100347602
gene id: 9986:LOC100347602
uniprot id: G1SEK2
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100350081
gene id: 9986:LOC100350081
uniprot id: G1SIN4
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100353091
gene id: 9986:LOC100353091
uniprot id: A0A5F9DCP6
uniprot id: G1TU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100008808
gene id: 9986:LOC100008808
uniprot id: G1TBJ6
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100349814
gene id: 9986:LOC100349814
uniprot id: G1TUN6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100349705
gene id: 9986:LOC100349705
uniprot id: G1SUQ9
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9986:LOC100352831
gene id: 9986:LOC100352831
uniprot id: G1T593
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9986:LOC100357420
gene id: 9986:LOC100357420
uniprot id: G1SLB1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:CYP2C14
gene id: 9986:CYP2C14
uniprot id: P17666
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9986:LOC127482580
gene id: 9986:LOC127482580
uniprot id: G1SIL1
names: Similarity
messages: Belongs to the SNF7 family.

9986:LOC100354125
gene id: 9986:LOC100354125
uniprot id: A0A5F9CPS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9986:LOC100346684
gene id: 9986:LOC100346684
uniprot id: G1TSA4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9986:LOC100009580
gene id: 9986:LOC100009580
uniprot id: A0A5F9CNZ2
uniprot id: G1SK48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9986:LOC100352123
gene id: 9986:LOC100352123
uniprot id: G1T257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9986:LOC100355185
gene id: 9986:LOC100355185
uniprot id: G1SP04
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100345239
gene id: 9986:LOC100345239
uniprot id: G1SLJ3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340936
gene id: 9986:LOC100340936
uniprot id: A0A5F9CZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9986:EDN2
gene id: 9986:EDN2
uniprot id: G1SEY6
uniprot id: Q765Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9986:LOC100358370
gene id: 9986:LOC100358370
uniprot id: G1T0C1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9986:CD63
gene id: 9986:CD63
uniprot id: Q28709
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
messages: Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes. Interacts with SYT7 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro) (By similarity).
messages: extracellular exosome
messages: multivesicular body

9986:LOC100338967
gene id: 9986:LOC100338967
uniprot id: A0A5F9CZ48
uniprot id: G1T9C8
names: Similarity
messages: Belongs to the peptidase S1C family.

9986:LOC100337750
gene id: 9986:LOC100337750
uniprot id: G1TZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344588
gene id: 9986:LOC100344588
uniprot id: A0A5F9DHS5
uniprot id: A0A5F9DTI0
uniprot id: G1SMW7
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:S100A11
gene id: 9986:S100A11
uniprot id: P24480
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Cytoplasm
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.
messages: Nucleus
messages: Phosphorylation at Thr-7 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.
messages: Smooth muscle and non-muscle tissues.

9986:LOC100348139
gene id: 9986:LOC100348139
uniprot id: G1SES1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9986:LOC100346448
gene id: 9986:LOC100346448
uniprot id: G1T863
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9986:LOC100346697
gene id: 9986:LOC100346697
uniprot id: G1SHL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9986:LOC100356313
gene id: 9986:LOC100356313
uniprot id: G1SKV9
names: Similarity
messages: Belongs to the formin homology family. Cappuccino subfamily.

9986:LOC100342739
gene id: 9986:LOC100342739
uniprot id: G1TUW3
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9986:LOC100354957
gene id: 9986:LOC100354957
uniprot id: G1T1B7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9986:LOC100340133
gene id: 9986:LOC100340133
uniprot id: G1SV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9986:SLC12A3
gene id: 9986:SLC12A3
uniprot id: O18886
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9986:LOC100351587
gene id: 9986:LOC100351587
uniprot id: G1TI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346379
gene id: 9986:LOC100346379
uniprot id: G1TGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9986:LOC100337764
gene id: 9986:LOC100337764
uniprot id: G1T524
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9986:LOC100346700
gene id: 9986:LOC100346700
uniprot id: G1SWC1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100352882
gene id: 9986:LOC100352882
uniprot id: A0A5F9C445
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9986:LOC100339154
gene id: 9986:LOC100339154
uniprot id: A0A5F9CUP1
uniprot id: A0A5F9CZ57
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9986:LOC103350046
gene id: 9986:LOC103350046
uniprot id: A0A5F9CWP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:OLFR651 1
gene id: 9986:OLFR651_1
uniprot id: B8K1A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345427
gene id: 9986:LOC100345427
uniprot id: G1SDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9986:LOC100343059
gene id: 9986:LOC100343059
uniprot id: G1SUH9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:TLR4
gene id: 9986:TLR4
uniprot id: Q8MIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9986:LOC100344201
gene id: 9986:LOC100344201
uniprot id: A0A5F9CI80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9986:LOC100343091
gene id: 9986:LOC100343091
uniprot id: G1SGZ9
names: Similarity
messages: Belongs to the GPRASP family.

9986:LOC100351193
gene id: 9986:LOC100351193
uniprot id: G1SMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9986:LOC100348000
gene id: 9986:LOC100348000
uniprot id: G1T7R1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9986:LOC100351032
gene id: 9986:LOC100351032
uniprot id: G1SHZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9986:LOC100357823
gene id: 9986:LOC100357823
uniprot id: G1U2K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356452
gene id: 9986:LOC100356452
uniprot id: G1SSW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9986:LOC100357306
gene id: 9986:LOC100357306
uniprot id: A0A5F9DSC7
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9986:LOC100344359
gene id: 9986:LOC100344359
uniprot id: G1SIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9986:LOC100343841
gene id: 9986:LOC100343841
uniprot id: G1SI48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100346261
gene id: 9986:LOC100346261
uniprot id: A0A5F9CMZ9
uniprot id: A0A5F9D1X6
uniprot id: A0A5F9DHZ1
uniprot id: G1SNG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

9986:LOC100340848
gene id: 9986:LOC100340848
uniprot id: G1TGV6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:LOC100352848
gene id: 9986:LOC100352848
uniprot id: G1U186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349403
gene id: 9986:LOC100349403
uniprot id: G1SJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100347143
gene id: 9986:LOC100347143
uniprot id: G1SKN0
names: Similarity
messages: Belongs to the peptidase M16 family.

9986:LOC100354199
gene id: 9986:LOC100354199
uniprot id: G1T613
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9986:IARS1
gene id: 9986:IARS1
uniprot id: G1TCK9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:ATP1A1
gene id: 9986:ATP1A1
uniprot id: Q9N0Z6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Expressed in endocardial endothelial cells.
messages: Melanosome
messages: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1. Interacts with regulatory subunit FXYD3. Interacts with SIK1. Interacts with SLC35G1 and STIM1. Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity).
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange (PubMed:11738066).
messages: axon
messages: sarcolemma

9986:LOC100344649
gene id: 9986:LOC100344649
uniprot id: G1T4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:LOC100354763
gene id: 9986:LOC100354763
uniprot id: G1T0U8
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9986:LOC100349931
gene id: 9986:LOC100349931
uniprot id: G1T6Z9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:OLR153
gene id: 9986:OLR153
uniprot id: B8K1A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357468
gene id: 9986:LOC100357468
uniprot id: G1TBJ4
names: Similarity
messages: Belongs to the NDRG family.

9986:LOC100345683
gene id: 9986:LOC100345683
uniprot id: G1TWR1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100355355
gene id: 9986:LOC100355355
uniprot id: G1SQ88
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9986:LOC100357607
gene id: 9986:LOC100357607
uniprot id: G1T277
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9986:LOC100355681
gene id: 9986:LOC100355681
uniprot id: G1TAT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:IL18R1
gene id: 9986:IL18R1
uniprot id: B3VBV3
uniprot id: G1TBQ0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9986:LOC100343656
gene id: 9986:LOC100343656
uniprot id: G1TQK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9986:LOC100328967
gene id: 9986:LOC100328967
uniprot id: P01894
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

9986:LOC100355640
gene id: 9986:LOC100355640
uniprot id: G1SIX5
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LDHB
gene id: 9986:LDHB
uniprot id: A0A5F9DPL1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9986:LOC100347252
gene id: 9986:LOC100347252
uniprot id: G1SGT5
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9986:ORYCUNV1R1538
gene id: 9986:ORYCUNV1R1538
uniprot id: A0A5F9C5T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350507
gene id: 9986:LOC100350507
uniprot id: A0A5F9DW39
uniprot id: G1SM76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9986:LOC100303762
gene id: 9986:LOC100303762
uniprot id: G1SJH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9986:LOC100356177
gene id: 9986:LOC100356177
uniprot id: G1SN84
names: Subcellular Location Annotation
messages: Nucleus

9986:ACE2
gene id: 9986:ACE2
uniprot id: G1TEF4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9986:LOC100349389
gene id: 9986:LOC100349389
uniprot id: A0A5F9C1Y7
uniprot id: G1T0L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100350911
gene id: 9986:LOC100350911
uniprot id: G1TAL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:LOC100354982
gene id: 9986:LOC100354982
uniprot id: A0A5F9DTS2
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100351001
gene id: 9986:LOC100351001
uniprot id: A0A5F9DU48
uniprot id: G1SPA7
uniprot id: U3KNC4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100345531
gene id: 9986:LOC100345531
uniprot id: G1SQR2
names: Subcellular Location Annotation
messages: Cell membrane

9986:LOC100345742
gene id: 9986:LOC100345742
uniprot id: G1SWW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9986:LOC100009416
gene id: 9986:LOC100009416
uniprot id: G1T9I9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9986:LOC100348131
gene id: 9986:LOC100348131
uniprot id: G1T2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9986:LOC100341016
gene id: 9986:LOC100341016
uniprot id: G1T688
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9986:LOC100341031
gene id: 9986:LOC100341031
uniprot id: G1TX78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100338914
gene id: 9986:LOC100338914
uniprot id: G1SUU6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:PHKA2
gene id: 9986:PHKA2
uniprot id: G1TYY2
uniprot id: P46018
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: By phosphorylation of various serine residues and by calcium.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
messages: Predominantly expressed in liver and other non-muscle tissues.

9986:LOC100342572
gene id: 9986:LOC100342572
uniprot id: P08682
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: By ethanol.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9986:LOC100341267
gene id: 9986:LOC100341267
uniprot id: G1SZ10
names: Similarity
messages: Belongs to the DOCK family.

9986:LOC100354959
gene id: 9986:LOC100354959
uniprot id: G1SMZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100338015
gene id: 9986:LOC100338015
uniprot id: G1U0J1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100357402
gene id: 9986:LOC100357402
uniprot id: A0A5F9DCV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9986:LOC100358276
gene id: 9986:LOC100358276
uniprot id: A0A5F9C881
uniprot id: G1TBP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9986:LOC108177113
gene id: 9986:LOC108177113
uniprot id: A0A5F9CLG9
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100354852
gene id: 9986:LOC100354852
uniprot id: G1TBD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
messages: Secreted

9986:LOC100344546
gene id: 9986:LOC100344546
uniprot id: G1TRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353302
gene id: 9986:LOC100353302
uniprot id: G1TYL6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9986:LOC100354164
gene id: 9986:LOC100354164
uniprot id: G1U1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:RPS29
gene id: 9986:RPS29
uniprot id: G1U7M4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9986:LOC100357243
gene id: 9986:LOC100357243
uniprot id: G1SCG0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100355579
gene id: 9986:LOC100355579
uniprot id: G1TRL3
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:EPHX1
gene id: 9986:EPHX1
uniprot id: P04068
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).
messages: Endoplasmic reticulum membrane
messages: Inhibited by 10-hydroxystearamide and methoxy-arachidonyl fluorophosphate.
messages: Microsome membrane

9986:LOC100341001
gene id: 9986:LOC100341001
uniprot id: G1SRK1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9986:LOC103351901
gene id: 9986:LOC103351901
uniprot id: G1TKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345327
gene id: 9986:LOC100345327
uniprot id: G1SYD8
names: Similarity
messages: Belongs to the SEC6 family.

9986:LOC100342046
gene id: 9986:LOC100342046
uniprot id: U3KMG3
names: Similarity
messages: Belongs to the Bcl-2 family.

9986:LOC100340247
gene id: 9986:LOC100340247
uniprot id: G1TIV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9986:LOC100353693
gene id: 9986:LOC100353693
uniprot id: G1T611
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9986:LOC100350667
gene id: 9986:LOC100350667
uniprot id: G1SRE6
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

9986:CALU
gene id: 9986:CALU
uniprot id: A0A140TAW0
uniprot id: Q6XLQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CREC family.
messages: Detected in skeletal muscle (at protein level).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Interacts with GGCX (By similarity). Interacts with RYR1 in the presence of calcium ions, but not in the presence of EDTA.
messages: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). May modulate calcium release from the sarcoplasmic reticulum.
messages: Melanosome
messages: Membrane
messages: PubMed:16527250 attributed the differences between their clones to the existence of two separate genes. This seems rather unlikely, considering that the cDNAs are 100% identical outside of this clearly delimited zone.
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9986:DAG1
gene id: 9986:DAG1
uniprot id: Q28685
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autolytic cleavage produces the alpha and beta subunits. In cutaneous cells, as well as in certain pathological conditions, shedding of beta-dystroglycan can occur releasing a peptide of about 30 kDa (By similarity).
messages: Cell membrane
messages: Detected in brain, cardiac muscle and skeletal muscle (at protein level) (PubMed:16709410). Expressed in lung, brain, liver, kidney, diaphragm and stomach (PubMed:1741056).
messages: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells (By similarity). Also acts as a receptor for laminin LAMA5 (By similarity).
messages: Monomer. Heterodimer of alpha- and beta-dystroglycan subunits which are the central components of the dystrophin-glycoprotein complex. This complex then can form a dystrophin-associated glycoprotein complex (DGC) which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts (via the N-terminal of alphaDAG1) with LARGE1; the interaction enhances laminin binding. Interacts with SGCD. Interacts with AGR2 and AGR3. Interacts (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif. Interacts (betaDAG1, via its PPXY motif) with UTRN (via its WWW and ZZ domains); the interaction is inhibited by phosphorylation on the PPXY motif. Interacts (betaDAG1, via its phosphorylated PPXY motif) with the SH2 domain-containing proteins, FYN, CSK, NCK and SHC. Interacts (betaDAG1) with CAV3 (via a central WW-like domain); the interaction disrupts the binding of DMD. BetaDAG1 directly interacts with ANK3, but not with ANK2; this interaction does not interfere with DMD-binding and is required for retention at costameres (By similarity). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Interacts with POMGNT1 (By similarity).
messages: N-glycosylated.
messages: O-glycosylated (PubMed:9838223). POMGNT1 catalyzes the initial addition of N-acetylglucosamine, giving rise to the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety and thus providing the necessary basis for the addition of further carbohydrate moieties. Heavily O-glycosylated comprising of up to two thirds of its mass and the carbohydrate composition differs depending on tissue type. Mucin-type O-glycosylation is important for ligand binding activity. O-mannosylation is found in high abundance in both brain and muscle where the most abundant glycan is Sia-alpha-2-3-Gal-beta-1-4-Glc-NAc-beta-1-2-Man. In muscle, glycosylation on Thr-317, Thr-319 and Thr-379 by a phosphorylated O-mannosyl glycan with the structure 2-(N-acetylamido)-2-deoxygalactosyl-beta-1,3-2-(N-acetylamido)-2-deoxyglucosyl-beta-1,4-6-phosphomannose is mediated by like-acetylglucosaminyltransferase (LARGE1) protein amd is required for laminin binding. O-glycosylated in the N-terminal region with a core 1 or possibly core 8 glycan. The brain form displays a unique glycosylation pattern which is absent in other tissues; this form shows enhanced binding to laminin LAMA5 compared to the skeletal muscle form (By similarity).
messages: Postsynaptic cell membrane
messages: SRC-mediated phosphorylation of the PPXY motif of the beta subunit recruits SH2 domain-containing proteins, but inhibits binding to WWW domain-containing proteins, DMD and UTRN. This phosphorylation also inhibits nuclear entry (By similarity).
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity).
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9986:LOC100339316
gene id: 9986:LOC100339316
uniprot id: G1T6Q7
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9986:LOC100358153
gene id: 9986:LOC100358153
uniprot id: G1STN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100354397
gene id: 9986:LOC100354397
uniprot id: G1SHV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100357435
gene id: 9986:LOC100357435
uniprot id: G1SL42
names: Similarity
messages: Belongs to the NipSnap family.

9986:LOC100355380
gene id: 9986:LOC100355380
uniprot id: A0A5F9CXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

9986:IMPACT
gene id: 9986:IMPACT
uniprot id: Q5GFD8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPACT family.
messages: Cytoplasm
messages: Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity. Interaction with RPL39; this interaction occurs in a GCN1-independent manner. Associates with ribosomes; this interaction occurs in a GCN1-independent manner. Associates with actin; this interaction occurs in a GCN1-independent manner.
messages: The IMPACT locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is silenced.
messages: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.

9986:LOC100348395
gene id: 9986:LOC100348395
uniprot id: G1SH51
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9986:GJA5
gene id: 9986:GJA5
uniprot id: G1TQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:CGA
gene id: 9986:CGA
uniprot id: A0A0F7RQJ1
uniprot id: P07474
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9986:LOC100340576
gene id: 9986:LOC100340576
uniprot id: G1SPB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9986:LEAP2
gene id: 9986:LEAP2
uniprot id: B7NZL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9986:LOC100341328
gene id: 9986:LOC100341328
uniprot id: G1TQ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353031
gene id: 9986:LOC100353031
uniprot id: G1SD65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9986:LOC100352192
gene id: 9986:LOC100352192
uniprot id: G1T196
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
messages: Membrane

9986:LOC103349943
gene id: 9986:LOC103349943
uniprot id: G1U5T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9986:LOC100341885
gene id: 9986:LOC100341885
uniprot id: G1SWZ1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9986:LOC100339808
gene id: 9986:LOC100339808
uniprot id: G1SJT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9986:LOC100343052
gene id: 9986:LOC100343052
uniprot id: U3KMW7
names: Similarity
messages: Belongs to the peptidase C12 family.

9986:MSR1
gene id: 9986:MSR1
uniprot id: Q05585
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotrimer. Interacts with MYO18A.
messages: Membrane
messages: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).

9986:LOC100356135
gene id: 9986:LOC100356135
uniprot id: G1T271
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100357209
gene id: 9986:LOC100357209
uniprot id: G1SXM7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:CCNA2
gene id: 9986:CCNA2
uniprot id: H8YL89
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9986:LOC100354515
gene id: 9986:LOC100354515
uniprot id: G1SJ70
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9986:LOC100356094
gene id: 9986:LOC100356094
uniprot id: G1SPW1
names: Similarity
messages: Belongs to the PDS5 family.

9986:LAMB3
gene id: 9986:LAMB3
uniprot id: A0A0B5JSH0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100338390
gene id: 9986:LOC100338390
uniprot id: G1SEC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9986:LOC100340268
gene id: 9986:LOC100340268
uniprot id: A0A5F9CSV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9986:LOC100356523
gene id: 9986:LOC100356523
uniprot id: G1SRB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9986:LOC100341559
gene id: 9986:LOC100341559
uniprot id: G1U460
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9986:LOC100355616
gene id: 9986:LOC100355616
uniprot id: G1SIT8
names: Similarity
messages: Belongs to the Bcl-2 family.

9986:LOC100356868
gene id: 9986:LOC100356868
uniprot id: G1T1Q8
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9986:LOC100355951
gene id: 9986:LOC100355951
uniprot id: G1SIU3
names: Similarity
messages: Belongs to the arrestin family.

9986:LOC100348414
gene id: 9986:LOC100348414
uniprot id: G1SDS6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9986:LOC100349067
gene id: 9986:LOC100349067
uniprot id: A0A5F9C9M7
uniprot id: A0A5F9D482
uniprot id: G1TJH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9986:LOC100358241
gene id: 9986:LOC100358241
uniprot id: G1SR41
names: Similarity
messages: Belongs to the stathmin family.

9986:UTP25
gene id: 9986:UTP25
uniprot id: G1SKY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9986:LOC100343309
gene id: 9986:LOC100343309
uniprot id: A0A5F9D693
uniprot id: G1SUM3
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9986:LOC100352580
gene id: 9986:LOC100352580
uniprot id: A0A5F9D2L8
uniprot id: G1SE22
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9986:LOC100348537
gene id: 9986:LOC100348537
uniprot id: G1T7W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9986:LOC100356448
gene id: 9986:LOC100356448
uniprot id: G1SX90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9986:LOC100354283
gene id: 9986:LOC100354283
uniprot id: A0A5F9D8Q7
uniprot id: G1TBX7
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9986:PTGER3
gene id: 9986:PTGER3
uniprot id: A0A5F9CR02
uniprot id: A0A5F9DLT3
uniprot id: A0A5F9DNG7
uniprot id: P46069
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: In the kidney cortex and medulla, adrenal gland and stomach. In kidney, expression is higher in tubules in the outer medulla, with lower levels in cortex. In kidney cortex, expression is restricted to distal tubules.
messages: Interacts (via C-terminus) with MKLN1.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2) (PubMed:8119961). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).

9986:C1H11orf87
gene id: 9986:C1H11orf87
uniprot id: G1SEY3
names: Subcellular Location Annotation
messages: Membrane

9986:ZP3
gene id: 9986:ZP3
uniprot id: G1TA56
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Membrane
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9986:LOC100355068
gene id: 9986:LOC100355068
uniprot id: G1SW36
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9986:LOC100345324
gene id: 9986:LOC100345324
uniprot id: G1T9G8
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9986:LOC100342423
gene id: 9986:LOC100342423
uniprot id: G1TZ15
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100358235
gene id: 9986:LOC100358235
uniprot id: Q256T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:RAB2A
gene id: 9986:RAB2A
uniprot id: Q01971
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Brain and parietal cells.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).
messages: Melanosome
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.
messages: acrosome

9986:LOC100339155
gene id: 9986:LOC100339155
uniprot id: G1SP30
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342325
gene id: 9986:LOC100342325
uniprot id: G1STW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9986:LOC100355434
gene id: 9986:LOC100355434
uniprot id: A0A5F9DA08
uniprot id: A0A5F9DHN1
names: Similarity
messages: Belongs to the PAT1 family.

9986:LOC100343123
gene id: 9986:LOC100343123
uniprot id: G1TRM4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9986:LOC100358767
gene id: 9986:LOC100358767
uniprot id: G1TEM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9986:LOC100341565
gene id: 9986:LOC100341565
uniprot id: G1T5X7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:LOC100341440
gene id: 9986:LOC100341440
uniprot id: G1TXA3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9986:LOC100349172
gene id: 9986:LOC100349172
uniprot id: A0A5F9DIK6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100355946
gene id: 9986:LOC100355946
uniprot id: A0A5F9D8M8
uniprot id: A0A5F9D8Q9
uniprot id: G1SCY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9986:SLC12A4
gene id: 9986:SLC12A4
uniprot id: Q28677
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide and bumetanide.
messages: Belongs to the SLC12A transporter family.
messages: Homomultimer and heteromultimer with other K-Cl cotransporters.
messages: Inhibited by WNK3.
messages: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:8663127). May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable).
messages: Membrane
messages: N-glycosylated.
messages: Phosphorylated, phosphorylation may regulate transporter activity.

9986:LOC100342316
gene id: 9986:LOC100342316
uniprot id: G1TND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358195
gene id: 9986:LOC100358195
uniprot id: G1TE82
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100346114
gene id: 9986:LOC100346114
uniprot id: A0A5F9D3Q0
uniprot id: G1SGS7
names: Similarity
messages: Belongs to the UFL1 family.

9986:LOC100340846
gene id: 9986:LOC100340846
uniprot id: A0A5F9C7V5
uniprot id: A0A5F9CUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9986:LOC100338492
gene id: 9986:LOC100338492
uniprot id: G1SMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9986:LOC100345588
gene id: 9986:LOC100345588
uniprot id: G1SGR6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9986:LOC100351017
gene id: 9986:LOC100351017
uniprot id: G1SGL9
uniprot id: U3KM17
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100357426
gene id: 9986:LOC100357426
uniprot id: G1T588
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9986:LOC100355615
gene id: 9986:LOC100355615
uniprot id: A0A5F9CA22
uniprot id: A0A5F9DCV9
uniprot id: G1T5G1
names: Similarity
messages: Belongs to the beta-catenin family.

9986:LOC100347635
gene id: 9986:LOC100347635
uniprot id: G1TT32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347568
gene id: 9986:LOC100347568
uniprot id: A0A5F9D469
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100349223
gene id: 9986:LOC100349223
uniprot id: G1TFZ7
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100338258
gene id: 9986:LOC100338258
uniprot id: G1SWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100346435
gene id: 9986:LOC100346435
uniprot id: G1SRW3
names: Similarity
messages: Belongs to the CFAP36 family.

9986:LOC100339048
gene id: 9986:LOC100339048
uniprot id: G1TI33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CASQ1
gene id: 9986:CASQ1
uniprot id: P07221
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity).
messages: Detected in skeletal muscle (at protein level). Detected in skeletal muscle.
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Monomer; increases in response to a depletion of intracellular calcium. Homodimer. Homotetramer and homopolymer. Can form linear homooligomers. Ca(2+) ions promote oligomerization. Interacts (via C-terminal end and preferentially with the monomeric form) with STIM1; this interaction increases in response to a depletion of intracellular calcium, decreases both STIM1 aggregation and clustering, interaction of STIM1 with ORAI1 and store-operated Ca(2+) entry (SOCE) activity (By similarity). Interacts with ASPH and TRDN (PubMed:15731387, PubMed:19230141, PubMed:19398037).
messages: N-glycosylated.
messages: Phosphorylated at very low, substoichiometric levels when isolated from skeletal muscle sarcoplasmic reticulum (PubMed:1985907). Can be phosphorylated by CK2 at Thr-381 (in vitro), albeit with low efficiency, suggesting this is not a physiological CK2 substrate (PubMed:1985907). Not phosphorylated at Thr-381 (PubMed:22170046).
messages: Sarcoplasmic reticulum
messages: Sarcoplasmic reticulum lumen
messages: Sarcoplasmic reticulum membrane

9986:LOC100358265
gene id: 9986:LOC100358265
uniprot id: G1TDY4
names: Similarity
messages: Belongs to the bystin family.

9986:LOC100351751
gene id: 9986:LOC100351751
uniprot id: G1SSH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9986:LOC100344015
gene id: 9986:LOC100344015
uniprot id: G1TI09
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100345362
gene id: 9986:LOC100345362
uniprot id: G1SE78
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353754
gene id: 9986:LOC100353754
uniprot id: G1SCM0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9986:MIP
gene id: 9986:MIP
uniprot id: A4L9J0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side (By similarity).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2).
messages: Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure. Interacts (via C-terminus) with BFSP1 (via C-terminus) in aged lens fiber cells (By similarity).
messages: Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity).
messages: Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).
messages: gap junction

9986:CSTPP1
gene id: 9986:CSTPP1
uniprot id: G1SGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9986:LOC100354027
gene id: 9986:LOC100354027
uniprot id: G1U7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9986:LOC100357691
gene id: 9986:LOC100357691
uniprot id: A0A5F9CE52
uniprot id: A0A5F9CKU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9986:LOC100355311
gene id: 9986:LOC100355311
uniprot id: G1T1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9986:LOC100349147
gene id: 9986:LOC100349147
uniprot id: A0A5F9CYP3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100344479
gene id: 9986:LOC100344479
uniprot id: A0A5F9DJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9986:LUM
gene id: 9986:LUM
uniprot id: G1SP97
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9986:LOC100354919
gene id: 9986:LOC100354919
uniprot id: A0A5F9DK86
uniprot id: G1U329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9986:LOC100347960
gene id: 9986:LOC100347960
uniprot id: G1SXM9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:CCR3
gene id: 9986:CCR3
uniprot id: B5SU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SLC17A1
gene id: 9986:SLC17A1
uniprot id: Q28722
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney.
messages: Interacts with PDZK1.
messages: Kidney cortex and liver.

9986:LOC100348750
gene id: 9986:LOC100348750
uniprot id: A0A5F9CJY9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100342887
gene id: 9986:LOC100342887
uniprot id: G1T138
names: Similarity
messages: Belongs to the SKAP family.

9986:LOC100349328
gene id: 9986:LOC100349328
uniprot id: U3KPE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100351738
gene id: 9986:LOC100351738
uniprot id: G1SZP0
uniprot id: U3KM53
names: Similarity
messages: Belongs to the TOM1 family.

9986:LOC100344856
gene id: 9986:LOC100344856
uniprot id: G1T923
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9986:TACR2
gene id: 9986:TACR2
uniprot id: P79218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9986:RO60
gene id: 9986:RO60
uniprot id: A0A5F9CLW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9986:LOC100356959
gene id: 9986:LOC100356959
uniprot id: G1T5A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

9986:LOC100340057
gene id: 9986:LOC100340057
uniprot id: A0A5F9C9L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9986:LOC100358175
gene id: 9986:LOC100358175
uniprot id: G1T1Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:TPM1
gene id: 9986:TPM1
uniprot id: A0A5F9CLU9
uniprot id: A0A5F9CSS8
uniprot id: A0A5F9D5K0
uniprot id: A0A5F9D6U8
uniprot id: P58772
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer (PubMed:23832280). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity). Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus) (By similarity).
messages: Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9986:GPBAR1
gene id: 9986:GPBAR1
uniprot id: G1SP39
uniprot id: Q862A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed at high level in spleen. Expressed at lower level in thymus, heart, lung, liver, kidney, ileum, blood and adherent alveolar macrophage cells.
messages: Membrane
messages: Receptor for bile acid. Bile-acid binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity).

9986:LOC100356583
gene id: 9986:LOC100356583
uniprot id: G1SCK5
names: Similarity
messages: Belongs to the serpin family.

9986:LOC100342318
gene id: 9986:LOC100342318
uniprot id: G1SPA4
names: Similarity
messages: Belongs to the formin homology family. Cappuccino subfamily.

9986:LOC100351696
gene id: 9986:LOC100351696
uniprot id: G1STQ1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100358171
gene id: 9986:LOC100358171
uniprot id: G1T1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9986:SLC8A1
gene id: 9986:SLC8A1
uniprot id: Q28662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100359222
gene id: 9986:LOC100359222
uniprot id: G1T2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9986:LOC100355974
gene id: 9986:LOC100355974
uniprot id: A0A5F9DG06
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9986:LOC100358511
gene id: 9986:LOC100358511
uniprot id: G1T2N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9986:LOC100008757
gene id: 9986:LOC100008757
uniprot id: A0A5F9CAL5
uniprot id: A0A5F9DFI1
uniprot id: A0A5F9DPP2
uniprot id: G1U5U9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100339584
gene id: 9986:LOC100339584
uniprot id: A0A5F9DSH2
uniprot id: G1SSF3
names: Similarity
messages: Belongs to the FAM149 family.

9986:LOC100347561
gene id: 9986:LOC100347561
uniprot id: G1SXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9986:LOC100350535
gene id: 9986:LOC100350535
uniprot id: A0A5F9D6A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339630
gene id: 9986:LOC100339630
uniprot id: G1T4I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9986:LOC100358700
gene id: 9986:LOC100358700
uniprot id: G1SP71
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9986:LOC100355575
gene id: 9986:LOC100355575
uniprot id: G1T571
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100340411
gene id: 9986:LOC100340411
uniprot id: G1T1X4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9986:LOC100008956
gene id: 9986:LOC100008956
uniprot id: A0A5F9D0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:LOC100349919
gene id: 9986:LOC100349919
uniprot id: G1TB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9986:LOC103351486
gene id: 9986:LOC103351486
uniprot id: G1T4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347238
gene id: 9986:LOC100347238
uniprot id: G1SCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9986:LOC100345077
gene id: 9986:LOC100345077
uniprot id: G1T0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100346181
gene id: 9986:LOC100346181
uniprot id: G1SV49
uniprot id: U3KN36
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100358159
gene id: 9986:LOC100358159
uniprot id: G1TIR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9986:LOC100352090
gene id: 9986:LOC100352090
uniprot id: A0A5F9CGQ5
uniprot id: A0A5F9CYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9986:LOC100343969
gene id: 9986:LOC100343969
uniprot id: A0A5F9D0B0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9986:LOC103344934
gene id: 9986:LOC103344934
uniprot id: G1TLT8
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9986:LOC100358285
gene id: 9986:LOC100358285
uniprot id: G1TAZ4
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9986:MYH4
gene id: 9986:MYH4
uniprot id: Q28641
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9986:ANXA1
gene id: 9986:ANXA1
uniprot id: P51662
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
messages: Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
messages: In the lung, expressed in the ciliated cells of the tracheal endothelium, but not in the goblet cells. Expressed in type II pneumocytes and alveolar macrophages.
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment.
messages: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation ofthe formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
messages: Secreted
messages: Sumoylated.
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9986:LOC100338724
gene id: 9986:LOC100338724
uniprot id: A0A5F9C8V8
uniprot id: A0A5F9CG88
uniprot id: A0A5F9D6R2
uniprot id: G1T865
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9986:LOC100338578
gene id: 9986:LOC100338578
uniprot id: A0A5F9CBT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9986:LOC100358944
gene id: 9986:LOC100358944
uniprot id: A0A5F9DJ29
uniprot id: G1SI47
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345729
gene id: 9986:LOC100345729
uniprot id: G1T7Y1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9986:LOC100347490
gene id: 9986:LOC100347490
uniprot id: U3KPK9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100355636
gene id: 9986:LOC100355636
uniprot id: G1TP81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9986:LOC100341976
gene id: 9986:LOC100341976
uniprot id: G1SP83
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9986:LOC100357743
gene id: 9986:LOC100357743
uniprot id: G1U7S4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9986:LOC100356359
gene id: 9986:LOC100356359
uniprot id: A0A5F9CCH2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9986:LOC100346703
gene id: 9986:LOC100346703
uniprot id: A0A5F9CV69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9986:LOC100348405
gene id: 9986:LOC100348405
uniprot id: G1SWU2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:LOC100345617
gene id: 9986:LOC100345617
uniprot id: G1SE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9986:LOC100344256
gene id: 9986:LOC100344256
uniprot id: G1T341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9986:LOC100351834
gene id: 9986:LOC100351834
uniprot id: G1TQC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100359072
gene id: 9986:LOC100359072
uniprot id: G1U7J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9986:LOC100343296
gene id: 9986:LOC100343296
uniprot id: G1SWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341677
gene id: 9986:LOC100341677
uniprot id: A0A5F9C5U5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9986:LOC100348886
gene id: 9986:LOC100348886
uniprot id: U3KMT4
names: Subcellular Location Annotation
messages: Membrane

9986:TPT1
gene id: 9986:TPT1
uniprot id: P43348
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Interacts with STEAP3.
messages: Involved in calcium binding and microtubule stabilization.
messages: Undergoes developmental regulation during mammary gland development.

9986:LOC100359137
gene id: 9986:LOC100359137
uniprot id: A0A5F9C5D5
uniprot id: G1T109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9986:PLTP
gene id: 9986:PLTP
uniprot id: Q8WMQ5
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9986:LOC100338895
gene id: 9986:LOC100338895
uniprot id: A0A5F9DC81
uniprot id: G1SNF1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100347461
gene id: 9986:LOC100347461
uniprot id: G1SY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9986:LOC100351388
gene id: 9986:LOC100351388
uniprot id: G1SZI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9986:LOC100353469
gene id: 9986:LOC100353469
uniprot id: G1U344
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9986:LOC100344212
gene id: 9986:LOC100344212
uniprot id: G1SU07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

9986:AK3
gene id: 9986:AK3
uniprot id: Q95J94
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9986:LOC100358761
gene id: 9986:LOC100358761
uniprot id: G1TK10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9986:LOC103348824
gene id: 9986:LOC103348824
uniprot id: G1SCS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100354951
gene id: 9986:LOC100354951
uniprot id: G1TYL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9986:LOC100344710
gene id: 9986:LOC100344710
uniprot id: A0A5F9C5R5
uniprot id: A0A5F9DI61
names: Similarity
messages: Belongs to the CCDC149 family.

9986:LOC100348676
gene id: 9986:LOC100348676
uniprot id: G1T9H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9986:C9H18orf32
gene id: 9986:C9H18orf32
uniprot id: G1TZR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9986:LOC100352868
gene id: 9986:LOC100352868
uniprot id: G1U1C0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100338179
gene id: 9986:LOC100338179
uniprot id: G1SIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9986:LOC100345790
gene id: 9986:LOC100345790
uniprot id: A0A5F9DGQ9
uniprot id: G1SF76
names: Similarity
messages: Belongs to the ITPK1 family.

9986:LOC100338725
gene id: 9986:LOC100338725
uniprot id: G1TZK5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9986:LOC100340405
gene id: 9986:LOC100340405
uniprot id: G1T7H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9986:LOC103351517
gene id: 9986:LOC103351517
uniprot id: G1T5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9986:LOC100355215
gene id: 9986:LOC100355215
uniprot id: G1TJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9986:LOC100349940
gene id: 9986:LOC100349940
uniprot id: G1TSD3
names: Similarity
messages: Belongs to the thioesterase family.

9986:LOC100352700
gene id: 9986:LOC100352700
uniprot id: A0A5F9DKQ7
uniprot id: G1SKG9
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9986:LOC100340464
gene id: 9986:LOC100340464
uniprot id: A0A5F9C7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353861
gene id: 9986:LOC100353861
uniprot id: G1U7Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9986:LOC100344663
gene id: 9986:LOC100344663
uniprot id: A0A5F9CR67
uniprot id: U3KPQ8
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9986:LOC100344632
gene id: 9986:LOC100344632
uniprot id: A0A5F9DS82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9986:LOC100357727
gene id: 9986:LOC100357727
uniprot id: G1SP54
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9986:TNFAIP8L2
gene id: 9986:TNFAIP8L2
uniprot id: B7NZC7
names: Domain
names: Function
names: Similarity
messages: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
messages: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
messages: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).

9986:LOC100351515
gene id: 9986:LOC100351515
uniprot id: G1TXC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100340255
gene id: 9986:LOC100340255
uniprot id: G1SJP3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9986:LOC100356541
gene id: 9986:LOC100356541
uniprot id: A0A5F9DJX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9986:LOC100338905
gene id: 9986:LOC100338905
uniprot id: A0A5F9CQ57
uniprot id: A0A5F9DA29
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9986:LOC100347185
gene id: 9986:LOC100347185
uniprot id: G1U1P5
names: Similarity
messages: Belongs to the BEX family.

9986:LOC100341511
gene id: 9986:LOC100341511
uniprot id: A0A5F9DMH9
names: Similarity
messages: Belongs to the TMEM70 family.

9986:LOC100352856
gene id: 9986:LOC100352856
uniprot id: A0A5F9CMQ0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100349913
gene id: 9986:LOC100349913
uniprot id: A0A5F9CUC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9986:LOC100347975
gene id: 9986:LOC100347975
uniprot id: A0A5F9CI48
names: Similarity
messages: Belongs to the peptidase M10A family.

9986:LOC100343405
gene id: 9986:LOC100343405
uniprot id: A0A5F9CV25
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9986:PPP2R5D
gene id: 9986:PPP2R5D
uniprot id: Q28653
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: Highly expressed in brain.
messages: Nomenclature used in PubMed:8576224 refers to PP2A B subunit B' gamma isoform, which is cited as PP2A B subunit delta-PR61 isoform in later publications.
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with ADCY8 (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9986:LOC100352657
gene id: 9986:LOC100352657
uniprot id: G1SSW6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100350037
gene id: 9986:LOC100350037
uniprot id: G1SLK6
names: Similarity
messages: Belongs to the SMARCD family.

9986:LOC100348510
gene id: 9986:LOC100348510
uniprot id: G1SLA7
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9986:LOC100349037
gene id: 9986:LOC100349037
uniprot id: A0A654ICM1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100354769
gene id: 9986:LOC100354769
uniprot id: G1SL14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9986:LOC100354625
gene id: 9986:LOC100354625
uniprot id: A0A5F9C1W5
uniprot id: G1SX67
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:RPL35A
gene id: 9986:RPL35A
uniprot id: G1SF08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9986:LOC100340949
gene id: 9986:LOC100340949
uniprot id: G1TFI6
names: Subunit
messages: Interacts with hair keratins.

9986:LOC100343130
gene id: 9986:LOC100343130
uniprot id: A0A5F9CEP7
uniprot id: A0A5F9CPZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9986:LOC100347660
gene id: 9986:LOC100347660
uniprot id: G1SSV3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9986:LOC100353540
gene id: 9986:LOC100353540
uniprot id: G1TLF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:CTSE
gene id: 9986:CTSE
uniprot id: P43159
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Glycosylated. The nature of the carbohydrate chain varies between cell types (By similarity).
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity).

9986:LOC100358708
gene id: 9986:LOC100358708
uniprot id: G1SN19
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100338273
gene id: 9986:LOC100338273
uniprot id: G1SCP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9986:SLC46A1
gene id: 9986:SLC46A1
uniprot id: G1STT6
names: Subcellular Location Annotation
messages: Membrane

9986:CETP
gene id: 9986:CETP
uniprot id: G1T4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.
messages: Secreted

9986:LOC100353970
gene id: 9986:LOC100353970
uniprot id: A0A5F9C6R4
uniprot id: G1SVX9
names: Subcellular Location Annotation
messages: P-body

9986:LOC100350591
gene id: 9986:LOC100350591
uniprot id: G1SQL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100353533
gene id: 9986:LOC100353533
uniprot id: A0A5F9D4V5
uniprot id: U3KM00
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9986:SLC5A4
gene id: 9986:SLC5A4
uniprot id: B7NZN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9986:LOC100354218
gene id: 9986:LOC100354218
uniprot id: G1TXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9986:LOC100352706
gene id: 9986:LOC100352706
uniprot id: G1TZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100343898
gene id: 9986:LOC100343898
uniprot id: G1T1P3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9986:LOC100348513
gene id: 9986:LOC100348513
uniprot id: A0A5F9DUK5
names: Similarity
messages: Belongs to the CFAP43 family.

9986:LOC100348682
gene id: 9986:LOC100348682
uniprot id: G1SI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9986:LOC100348219
gene id: 9986:LOC100348219
uniprot id: G1U2W1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100347590
gene id: 9986:LOC100347590
uniprot id: G1T4K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9986:FMO2
gene id: 9986:FMO2
uniprot id: P17635
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:3785145, PubMed:10950853, PubMed:16620765, PubMed:11302936, PubMed:15144220, PubMed:15294458). Most drug substrates are tertiary amines such as prochlorperazine and trifluoperazine which are N-oxygenated to form the N-oxide, or sulfides such as thiourea and ethionamide, which are S-oxygenated to the sulfoxide (PubMed:3785145, PubMed:15144220, PubMed:16620765). Others include primary alkylamines such as N-dodecylamine and octan-1-amine that are sequentially monooxygenated to oximes through intermediate hydroxylamines and both steps are NADPH- and oxygen-dependent (PubMed:3785145). Also metabolized N-Deacetyl ketoconazole (DAK) to N-hydroxy-DAK and appears to further metabolizes N-hydroxy-DAK to two others metabolites (PubMed:10950853). Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton (PubMed:15294458).
messages: Endoplasmic reticulum membrane
messages: Lung.
messages: Microsome membrane
messages: There are two allelic forms.

9986:LOC100357074
gene id: 9986:LOC100357074
uniprot id: G1SI91
names: Subcellular Location Annotation
messages: Nucleus

9986:KITLG
gene id: 9986:KITLG
uniprot id: Q2I093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9986:LOC100342862
gene id: 9986:LOC100342862
uniprot id: A0A5F9C5C3
uniprot id: G1SE08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100357470
gene id: 9986:LOC100357470
uniprot id: A0A5F9DUM4
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9986:LOC100350107
gene id: 9986:LOC100350107
uniprot id: P62160
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.
messages: Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). Interacts with HINT1; interaction increases in the presence of calcium ions (By similarity). Interacts with HINT3 (By similarity).
messages: Phosphorylation results in a decreased activity.
messages: The N-terminus is blocked.
messages: This protein has four functional calcium-binding sites.
messages: Ubiquitination results in a strongly decreased activity.
messages: spindle
messages: spindle pole

9986:LOC100344790
gene id: 9986:LOC100344790
uniprot id: G1SSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9986:LOC100352603
gene id: 9986:LOC100352603
uniprot id: W0UUZ9
names: Function
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.

9986:LOC100340894
gene id: 9986:LOC100340894
uniprot id: G1SW16
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100357910
gene id: 9986:LOC100357910
uniprot id: G1TAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9986:LOC103351890
gene id: 9986:LOC103351890
uniprot id: A0A5F9C6B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349525
gene id: 9986:LOC100349525
uniprot id: G1SVA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9986:LOC100345436
gene id: 9986:LOC100345436
uniprot id: A0A5F9D1U7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100341471
gene id: 9986:LOC100341471
uniprot id: A0A5F9CDJ0
uniprot id: A0A5F9D259
uniprot id: G1TI97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9986:LOC100350899
gene id: 9986:LOC100350899
uniprot id: G1SWC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9986:LOC100342529
gene id: 9986:LOC100342529
uniprot id: A0A5F9CMT0
uniprot id: G1T2H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100342989
gene id: 9986:LOC100342989
uniprot id: G1SJ46
names: Similarity
messages: Belongs to the CutC family.

9986:TAAR4
gene id: 9986:TAAR4
uniprot id: G1U8E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100340528
gene id: 9986:LOC100340528
uniprot id: G1T6N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9986:GABRA1
gene id: 9986:GABRA1
uniprot id: G1TAX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100348087
gene id: 9986:LOC100348087
uniprot id: G1TBH1
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9986:VIRMA
gene id: 9986:VIRMA
uniprot id: A0A5F9D6N2
uniprot id: G1TBR6
uniprot id: U3KN28
names: Similarity
messages: Belongs to the vir family.

9986:LOC100340175
gene id: 9986:LOC100340175
uniprot id: A0A5F9CSQ9
uniprot id: A0A5F9DPA3
uniprot id: G1TBS8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:SLC34A1
gene id: 9986:SLC34A1
uniprot id: Q28620
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Expressed in the kidney cortex.
messages: Interacts via its C-terminal region with PDZK2. Interacts with SLC9A3R1.
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7733319). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity).
messages: Transport activity is significantly increased in response to dietary phosphate deprivation.
messages: Up-regulated by a low-phosphate diet.

9986:LOC100338831
gene id: 9986:LOC100338831
uniprot id: G1TEN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9986:LOC100353695
gene id: 9986:LOC100353695
uniprot id: G1TTE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100338014
gene id: 9986:LOC100338014
uniprot id: A0A5F9C4L9
uniprot id: A0A5F9CG21
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9986:LOC100356147
gene id: 9986:LOC100356147
uniprot id: G1SXR3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9986:HOATZ
gene id: 9986:HOATZ
uniprot id: G1T4A2
names: Similarity
messages: Belongs to the HOATZ family.

9986:LOC100348389
gene id: 9986:LOC100348389
uniprot id: G1T096
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9986:LOC100346592
gene id: 9986:LOC100346592
uniprot id: G1TTD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9986:LOC100358384
gene id: 9986:LOC100358384
uniprot id: G1TC95
names: Similarity
messages: Belongs to the MAP7 family.

9986:LOC100340135
gene id: 9986:LOC100340135
uniprot id: G1TUT8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342622
gene id: 9986:LOC100342622
uniprot id: G1U042
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9986:DNAI7
gene id: 9986:DNAI7
uniprot id: G1TAN0
names: Similarity
messages: Belongs to the DNAI7 family.

9986:LOC100358617
gene id: 9986:LOC100358617
uniprot id: G1T3K3
names: Similarity
messages: Belongs to the YOS1 family.

9986:LOC100354423
gene id: 9986:LOC100354423
uniprot id: G1SZ29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9986:LOC100343451
gene id: 9986:LOC100343451
uniprot id: G1SMY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9986:LOC100342206
gene id: 9986:LOC100342206
uniprot id: G1T4I9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100359271
gene id: 9986:LOC100359271
uniprot id: G1SLW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9986:LOC100009029
gene id: 9986:LOC100009029
uniprot id: G1T1V0
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100355802
gene id: 9986:LOC100355802
uniprot id: G1SIK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9986:LOC108175358
gene id: 9986:LOC108175358
uniprot id: G1SWI6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9986:LOC100341364
gene id: 9986:LOC100341364
uniprot id: A0A5F9CQM6
uniprot id: A0A5F9D7X8
uniprot id: A0A5F9DPD7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9986:LOC100353489
gene id: 9986:LOC100353489
uniprot id: G1SST9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9986:LOC100338994
gene id: 9986:LOC100338994
uniprot id: A0A5F9D5D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Cytoplasm

9986:LOC108176424
gene id: 9986:LOC108176424
uniprot id: U3KP35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:LOC100355805
gene id: 9986:LOC100355805
uniprot id: G1SYD2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9986:LOC100346092
gene id: 9986:LOC100346092
uniprot id: G1SQK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

9986:ASB3
gene id: 9986:ASB3
uniprot id: G1T5R9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:CLDN12
gene id: 9986:CLDN12
uniprot id: B6A7Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9986:PCBP1
gene id: 9986:PCBP1
uniprot id: O19048
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated; lowers poly(rC)-binding activity.
messages: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity).

9986:LOC100351843
gene id: 9986:LOC100351843
uniprot id: G1SKI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9986:TGFB2
gene id: 9986:TGFB2
uniprot id: A0A5F9CKJ8
uniprot id: Q6T7C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9986:LOC100356822
gene id: 9986:LOC100356822
uniprot id: G1TCU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338410
gene id: 9986:LOC100338410
uniprot id: A0A5F9CSL7
uniprot id: A0A5F9CWZ3
uniprot id: G1TZ69
names: Similarity
messages: Belongs to the AP-2 family.

9986:LOC100351856
gene id: 9986:LOC100351856
uniprot id: A0A5F9D5B4
uniprot id: A0A5F9DSU2
uniprot id: G1SLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9986:LOC100340838
gene id: 9986:LOC100340838
uniprot id: G1SX03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9986:EIF2B5
gene id: 9986:EIF2B5
uniprot id: P47823
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Interacts with RGS2 (By similarity).
messages: Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B. Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function (By similarity).
messages: Polyubiquitinated, probably by NEDD4.
messages: Ubiquitously expressed.

9986:CACNB1
gene id: 9986:CACNB1
uniprot id: A0A5F9C0R9
uniprot id: P19517
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: Regulatory subunit of L-type calcium channels (PubMed:7509046). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (PubMed:7509046). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity).
messages: Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits (PubMed:7509046, PubMed:27580036). Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S (PubMed:7509046). Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:27580036). Identified in a complex with CACNA1C (PubMed:7509046, PubMed:21127204). Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (PubMed:21127204). Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1. Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (By similarity). Interacts with JSRP1. Interacts with RYR1 (By similarity). Interacts with CBARP (By similarity).
messages: The N-terminus is blocked.
messages: sarcolemma

9986:LOC100357449
gene id: 9986:LOC100357449
uniprot id: A0A5F9D214
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9986:THBD
gene id: 9986:THBD
uniprot id: Q8HZ48
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9986:LOC100339411
gene id: 9986:LOC100339411
uniprot id: G1TBY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9986:LOC100354106
gene id: 9986:LOC100354106
uniprot id: G1TYR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9986:LOC100348584
gene id: 9986:LOC100348584
uniprot id: G1T7N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Endosome

9986:LOC100342687
gene id: 9986:LOC100342687
uniprot id: G1U6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343206
gene id: 9986:LOC100343206
uniprot id: G1U5D9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:CACNA1S
gene id: 9986:CACNA1S
uniprot id: P07293
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily.
messages: Channel activity is blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:3037387, PubMed:27621462, PubMed:15134636, PubMed:25667046, PubMed:26680202, PubMed:27580036). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (PubMed:15134636, PubMed:25667046, PubMed:26680202, PubMed:27580036). CACNA1S channel activity is modulated by the auxiliary subunits (CACNB1 or CACNB2, CACNG1 and CACNA2D1). Interacts with DYSF and JSRP1 (By similarity). Interacts with RYR1 (PubMed:10388749). Interacts with STAC, STAC2 and STAC3 (via their SH3 domains) (PubMed:28112192, PubMed:29078335, PubMed:29467163). Interaction with STAC3 promotes expression at the cell membrane (PubMed:25548159, PubMed:29467163). Interaction with STAC2 promotes expression at the cell membrane, but with much lower efficiency than STAC3. Interaction with STAC1 leads to very low levels expression at the cell membrane, much less than the levels observed upon interaction with STAC3 and STAC2 (PubMed:29467163). Interacts with CALM (By similarity).
messages: Detected in skeletal muscle T-tubules (at protein level).
messages: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
messages: Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA (PubMed:2549550, PubMed:2844809). Phosphorylation at Ser-1575 is involved in beta-adrenergic-mediated regulation of the channel (PubMed:20937870).
messages: Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115 PubMed:15201141, PubMed:27621462). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
messages: T-tubule
messages: The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690.
messages: The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction.

9986:LOC100353366
gene id: 9986:LOC100353366
uniprot id: G1SX40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9986:LOC100358948
gene id: 9986:LOC100358948
uniprot id: G1SM90
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9986:LOC100346479
gene id: 9986:LOC100346479
uniprot id: G1TN78
names: Similarity
messages: Belongs to the FAM72 family.

9986:CASQ2
gene id: 9986:CASQ2
uniprot id: P31235
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
messages: Detected in heart muscle (at protein level).
messages: Monomer, homodimer and homooligomer. Mostly monomeric in the absence of calcium. Forms higher oligomers in a calcium-dependent manner. Dimers associate to form tetramers, that then form linear homomer chains. Interacts with ASPH and TRDN (By similarity).
messages: N-glycosylated.
messages: Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.
messages: Sarcoplasmic reticulum lumen

9986:ORYCUNV1R1666
gene id: 9986:ORYCUNV1R1666
uniprot id: A0A5F9D0C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355052
gene id: 9986:LOC100355052
uniprot id: G1TWM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100008679
gene id: 9986:LOC100008679
uniprot id: Q95218
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DMBT1 family.
messages: Expressed in small intestine, liver, stomach and kidney. Present in small intestine and in collecting tubules of kidney cortex, medulla and papilla (at protein level).
messages: Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity).
messages: Interacts with LGALS3. Binds SFTPD and SPAR in a calcium-dependent manner (By similarity).
messages: May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell (By similarity).
messages: Secreted
messages: The SRCR domains mediate binding to bacteria.

9986:GPI
gene id: 9986:GPI
uniprot id: Q9N1E2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Homodimer in the catalytically active form, monomer in the secreted form.
messages: ISGylated.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
messages: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
messages: Secreted

9986:EDNRB
gene id: 9986:EDNRB
uniprot id: D6CI21
uniprot id: Q9N0W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

9986:LOC100337986
gene id: 9986:LOC100337986
uniprot id: U3KM11
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100348099
gene id: 9986:LOC100348099
uniprot id: G1SVM5
names: Similarity
messages: Belongs to the neuritin family.

9986:LOC100341766
gene id: 9986:LOC100341766
uniprot id: G1SQ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100358453
gene id: 9986:LOC100358453
uniprot id: A0A5F9CCS7
uniprot id: G1SMK1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100356305
gene id: 9986:LOC100356305
uniprot id: A0A5F9CEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9986:LOC100349313
gene id: 9986:LOC100349313
uniprot id: U3KPG5
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9986:LOC100340819
gene id: 9986:LOC100340819
uniprot id: G1SVS1
names: Similarity
messages: Belongs to the MAK16 family.

9986:DIPK2B
gene id: 9986:DIPK2B
uniprot id: G1T826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9986:LOC100355883
gene id: 9986:LOC100355883
uniprot id: G1U5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9986:LOC100349417
gene id: 9986:LOC100349417
uniprot id: G1TLL6
names: Similarity
messages: Belongs to the sorting nexin family.

9986:LOC100347644
gene id: 9986:LOC100347644
uniprot id: G1SV97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

9986:HLTF
gene id: 9986:HLTF
uniprot id: Q95216
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.
messages: Cytoplasm
messages: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA (By similarity). Transcriptional regulator that mediates the ability of prolactin to augment progesterone-dependent transcription of the SCGB1A1/uteroglobin gene through a bipartite progesterone receptor half-site/overlapping Y-box combination (-38/-26) where progesterone activation is attenuated by nuclear factor Y binding. Regulation also involves two GC-rich sequences in the proximal promoter (positions -162/+90) and a RUSH/SMARCA3 site (positions -616/-611) in the 5'-untranslated region.
messages: Interacts with SP1 and SP3 independently of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes (By similarity). Interacts (via the RING-finger) with isoform RFBP of ATP11B. Progesterone-dependent isoform 1 interacts with EGR1; the interaction requires prior binding to DNA and represses c-Rel via a DNA looping mechanism. Interacts with GATA4. Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N (By similarity).
messages: Isoform 1 is expressed preferentially in bladder, cervix, diaphragm, duodenum, epididymis, heart, kidney, liver, lung, ovary (granulosa cells), prostate, spleen, testis (predominantly in the Sertoli cells of the seminiferous tubules) and vagina. Isoform 2 is expressed preferentially in lactating mammary gland and uterine endometrium.
messages: Isoform RUSH 1-alpha expression is increased by progesterone and decreased by estradiol. Progesterone induction is increased in the presence of prolactin. Isoform RUSH 1-beta/RFBP expression is increased by estrogen and decreased by progesterone.
messages: Major isoform in progesterone-dominant endometrium.
messages: Phosphorylated on serine, threonine, and tyrosine residues. Tyr-195 phosphorylation is catalyzed by JAK2 in response to prolactin treatment. It is required for DNA binding.
messages: Truncated, estrogen-dependent isoform.
messages: nucleolus
messages: nucleoplasm

9986:LOC100347657
gene id: 9986:LOC100347657
uniprot id: G1TMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:ADH1A
gene id: 9986:ADH1A
uniprot id: Q03505
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

9986:LOC100339810
gene id: 9986:LOC100339810
uniprot id: G1SEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9986:LOC100357943
gene id: 9986:LOC100357943
uniprot id: G1T682
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:TRPC1
gene id: 9986:TRPC1
uniprot id: G1TE94
uniprot id: Q9TUN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Homotetramer and heterotetramer with TRPC4 and/or TRPC5 (By similarity). Interacts with TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with FKBP4 (By similarity). Interacts with TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity).
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9986:BPIFC
gene id: 9986:BPIFC
uniprot id: B7NZN3
uniprot id: G1SUV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9986:OR51B4
gene id: 9986:OR51B4
uniprot id: B8K177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:HCN1
gene id: 9986:HCN1
uniprot id: G1TCZ4
uniprot id: Q9MZS1
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding promotes tetramerization and formation of an active channel. Compared to other family members, cAMP has less stimulatory effect on HCN1 because part of the molecules already contain bound cAMP and form homotetramers when cAMP levels are low.
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Detected in myocytes in heart sinoatrial node (SAN) and in brain, in particular in the granule cell layer and in Purkinje neuron bodies in the cerebellum.
messages: Homotetramer. Heterotetramer with HCN2. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCNE2. Interacts with the SH3 domain of CSK.
messages: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
messages: It is uncertain whether Met-1 or Met-30 is the initiator.
messages: Membrane
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9986:LOC100354915
gene id: 9986:LOC100354915
uniprot id: A0A5F9CLF6
uniprot id: A0A5F9D586
uniprot id: A0A5F9DPA6
names: Similarity
messages: Belongs to the nectin family.

9986:LOC100352959
gene id: 9986:LOC100352959
uniprot id: G1T1V9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9986:LOC100339741
gene id: 9986:LOC100339741
uniprot id: A0A5F9CRM1
uniprot id: G1TA73
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9986:LOC100343039
gene id: 9986:LOC100343039
uniprot id: G1SHQ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9986:LOC100355238
gene id: 9986:LOC100355238
uniprot id: G1TE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9986:NPY2R
gene id: 9986:NPY2R
uniprot id: B6VRS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347902
gene id: 9986:LOC100347902
uniprot id: G1SK00
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:LOC100356570
gene id: 9986:LOC100356570
uniprot id: G1TGZ6
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9986:LOC100342294
gene id: 9986:LOC100342294
uniprot id: G1SKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9986:PRL
gene id: 9986:PRL
uniprot id: G1SF54
uniprot id: Q28632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9986:SLC25A4
gene id: 9986:SLC25A4
uniprot id: O46373
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A4/ANT1. Interacts with ARL2BP. Interacts with TIMM44; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
messages: Under cell death induction, transglutaminated by TGM2. Transglutamination leads to formation of covalent cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming polymers.

9986:LOC100341281
gene id: 9986:LOC100341281
uniprot id: A0A5F9DB30
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9986:LOC100356747
gene id: 9986:LOC100356747
uniprot id: G1TW20
names: Similarity
messages: Belongs to the ZC3H12 family.

9986:LOC100339845
gene id: 9986:LOC100339845
uniprot id: A0A5F9CR96
names: Similarity
messages: Belongs to the BTG family.

9986:LOC100352502
gene id: 9986:LOC100352502
uniprot id: G1T2V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9986:C1H11orf54
gene id: 9986:C1H11orf54
uniprot id: G1T443
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9986:PPP2CA
gene id: 9986:PPP2CA
uniprot id: P67777
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with SGO1 and SGO2. Interacts with TP53. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain). Interacts with MFHAS1; retains PPP2CA into the cytoplasm and excludes it from the nucleus. Interacts with PABIR1/FAM122A. Interacts with ADCY8; interaction is phosphatase activity-dependent; antagonizes interaction between ADCY8 and calmodulin. Interacts with CRTC3 (when phosphorylated at 'Ser-391'). Interacts with SPRY2; the interaction is inhibited by TESK1 interaction with SPRY2, possibly by vesicular sequestration of SPRY2. Interacts with TRAF3IP3. Interacts with AMBRA1 (via PxP motifs); enhancing interaction between PPP2CA and MYC or FOXO3 (By similarity). Forms a complex with AMBRA1 and BECN1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways (By similarity).
messages: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (By similarity). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity).
messages: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity).
messages: Polyubiquitinated, leading to its degradation by the proteasome.
messages: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).
messages: centromere
messages: spindle pole

9986:LOC100346795
gene id: 9986:LOC100346795
uniprot id: G1U985
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:OLFR64 1
gene id: 9986:OLFR64_1
uniprot id: B8K179
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:ORYCUNV1R1632
gene id: 9986:ORYCUNV1R1632
uniprot id: G1U898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358006
gene id: 9986:LOC100358006
uniprot id: A0A5F9CVP7
uniprot id: G1SGX7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9986:STK17A
gene id: 9986:STK17A
uniprot id: Q9GM70
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a positive regulator of apoptosis. May also act as a regulator of cellular reactive oxygen species.
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
messages: Highly expressed in bone marrow. Lower levels in brain, heart, lung, liver and kidney.
messages: Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone- thiazolidinediones.
messages: Nucleus

9986:LOC100348179
gene id: 9986:LOC100348179
uniprot id: A0A5F9D3U5
names: Subcellular Location Annotation
messages: Nucleus

9986:HYCC2
gene id: 9986:HYCC2
uniprot id: G1SZT2
uniprot id: G1U4C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9986:LOC100344688
gene id: 9986:LOC100344688
uniprot id: U3KP83
names: Similarity
messages: Belongs to the actin family.

9986:LOC100340988
gene id: 9986:LOC100340988
uniprot id: G1T0E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9986:LOC100340950
gene id: 9986:LOC100340950
uniprot id: G1SRX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9986:LOC103351914
gene id: 9986:LOC103351914
uniprot id: U3KNB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9986:LOC100338541
gene id: 9986:LOC100338541
uniprot id: G1SLF5
names: Similarity
messages: Belongs to the oligoribonuclease family.

9986:ZNG1A
gene id: 9986:ZNG1A
uniprot id: G1TH48
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9986:LOC100358690
gene id: 9986:LOC100358690
uniprot id: P30947
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylatio…
messages: Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-257. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with PDCL3 (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interac…
messages: Nucleus
messages: Phosphorylation at Tyr-303 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-257 inhibits AHR interaction.
messages: S-nitrosylated; negatively regulates the ATPase activity.
messages: Secreted
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
messages: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).

9986:LOC100346816
gene id: 9986:LOC100346816
uniprot id: G1T6W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100351102
gene id: 9986:LOC100351102
uniprot id: A0A5F9D3K0
names: Similarity
messages: Belongs to the cullin family.

9986:LOC100354708
gene id: 9986:LOC100354708
uniprot id: G1SX35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9986:LOC100357567
gene id: 9986:LOC100357567
uniprot id: G1TNS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9986:TLR10
gene id: 9986:TLR10
uniprot id: G1SK84
uniprot id: M9T1R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9986:RLA-DRB1
gene id: 9986:RLA-DRB1
uniprot id: G1SFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:LOC100342633
gene id: 9986:LOC100342633
uniprot id: A0A5F9CCR3
uniprot id: G1TWL0
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9986:LOC100348164
gene id: 9986:LOC100348164
uniprot id: G1T7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100358363
gene id: 9986:LOC100358363
uniprot id: G1SFF8
names: Subcellular Location Annotation
messages: Membrane

9986:PAPSS2
gene id: 9986:PAPSS2
uniprot id: Q6IVV4
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9986:LOC100345163
gene id: 9986:LOC100345163
uniprot id: U3KLW5
names: Subcellular Location Annotation
messages: Membrane

9986:INSL5
gene id: 9986:INSL5
uniprot id: B1AAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9986:APP
gene id: 9986:APP
uniprot id: A0A5F9C8P7
uniprot id: A0A5F9CKY0
uniprot id: A0A5F9CLH6
uniprot id: A0A5F9DQE8
uniprot id: G1SZM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9986:LOC100340243
gene id: 9986:LOC100340243
uniprot id: G1U265
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100356265
gene id: 9986:LOC100356265
uniprot id: G1SKR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9986:LOC100350280
gene id: 9986:LOC100350280
uniprot id: G1SW39
names: Similarity
messages: Belongs to the enolase family.

9986:LOC100346091
gene id: 9986:LOC100346091
uniprot id: G1SHE2
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9986:ADH2-1
gene id: 9986:ADH2-1
uniprot id: O46649
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

9986:LOC100343944
gene id: 9986:LOC100343944
uniprot id: G1SGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100355153
gene id: 9986:LOC100355153
uniprot id: G1T6Y8
names: Similarity
messages: Belongs to the FAM199 family.

9986:LOC100353856
gene id: 9986:LOC100353856
uniprot id: G1TVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SGCB
gene id: 9986:SGCB
uniprot id: Q28635
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity).
messages: Disulfide bonds are present.
messages: cytoskeleton
messages: sarcolemma

9986:LOC100344577
gene id: 9986:LOC100344577
uniprot id: G1SDT6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100358949
gene id: 9986:LOC100358949
uniprot id: A0A5F9DPA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100354874
gene id: 9986:LOC100354874
uniprot id: A0A5F9D004
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9986:LOC100355347
gene id: 9986:LOC100355347
uniprot id: G1TP33
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100339570
gene id: 9986:LOC100339570
uniprot id: G1SLF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9986:LOC100348942
gene id: 9986:LOC100348942
uniprot id: G1SLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9986:ORYCUNV1R1621
gene id: 9986:ORYCUNV1R1621
uniprot id: G1TUS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353901
gene id: 9986:LOC100353901
uniprot id: G1T529
names: Similarity
messages: Belongs to the MS4A family.

9986:LOC100340218
gene id: 9986:LOC100340218
uniprot id: A0A5F9C739
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9986:LOC100340278
gene id: 9986:LOC100340278
uniprot id: G1TPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100351689
gene id: 9986:LOC100351689
uniprot id: G1TWG5
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

9986:LOC100349764
gene id: 9986:LOC100349764
uniprot id: A0A5F9CQ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100338619
gene id: 9986:LOC100338619
uniprot id: A0A5F9CF48
uniprot id: G1TH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9986:LOC100347160
gene id: 9986:LOC100347160
uniprot id: G1SQ02
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9986:LOC100348004
gene id: 9986:LOC100348004
uniprot id: A0A5F9D2Q3
uniprot id: G1T003
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9986:LOC100345733
gene id: 9986:LOC100345733
uniprot id: A0A5F9C0X9
names: Similarity
messages: Belongs to the API5 family.

9986:LOC100343735
gene id: 9986:LOC100343735
uniprot id: G1SJB1
names: Similarity
messages: Belongs to the actin family.

9986:LOC100339379
gene id: 9986:LOC100339379
uniprot id: A0A5F9CB21
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100348756
gene id: 9986:LOC100348756
uniprot id: G1SX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9986:LOC103350771
gene id: 9986:LOC103350771
uniprot id: A0A5F9D2V5
names: Similarity
messages: Belongs to the FAM47 family.

9986:LOC100357045
gene id: 9986:LOC100357045
uniprot id: G1SJG0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9986:KCNK5
gene id: 9986:KCNK5
uniprot id: Q5UE95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9986:LOC100357851
gene id: 9986:LOC100357851
uniprot id: U3KP89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9986:LOC100340463
gene id: 9986:LOC100340463
uniprot id: A0A5F9D859
uniprot id: G1SD18
names: Similarity
messages: Belongs to the FAM168 family.

9986:LOC100357148
gene id: 9986:LOC100357148
uniprot id: G1TNI4
uniprot id: G1TY06
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9986:LOC100358359
gene id: 9986:LOC100358359
uniprot id: G1U344
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9986:LOC100355856
gene id: 9986:LOC100355856
uniprot id: G1T8N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9986:LOC100340768
gene id: 9986:LOC100340768
uniprot id: G1TN41
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

9986:QARS1
gene id: 9986:QARS1
uniprot id: G1SN68
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:LOC100351326
gene id: 9986:LOC100351326
uniprot id: A0A5F9CNP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9986:LOC100008708
gene id: 9986:LOC100008708
uniprot id: G1SQ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9986:LOC100346402
gene id: 9986:LOC100346402
uniprot id: G1SVL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9986:LOC100359047
gene id: 9986:LOC100359047
uniprot id: G1U486
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9986:LOC100338267
gene id: 9986:LOC100338267
uniprot id: G1T3I9
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9986:LOC100009002
gene id: 9986:LOC100009002
uniprot id: A0A5F9CXR1
uniprot id: G1TC33
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:LOC100351432
gene id: 9986:LOC100351432
uniprot id: G1TQ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9986:LOC100358622
gene id: 9986:LOC100358622
uniprot id: G1SV96
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9986:LOC100359147
gene id: 9986:LOC100359147
uniprot id: G1SP68
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9986:PIP4P1
gene id: 9986:PIP4P1
uniprot id: G1SN20
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9986:LOC100355548
gene id: 9986:LOC100355548
uniprot id: G1T2L3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9986:LOC100338642
gene id: 9986:LOC100338642
uniprot id: A0A5F9C5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9986:DNAAF4
gene id: 9986:DNAAF4
uniprot id: A0A5F9CIZ6
uniprot id: G1THJ1
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: neuron projection

9986:EIF4A2
gene id: 9986:EIF4A2
uniprot id: G1SN05
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9986:LOC100338233
gene id: 9986:LOC100338233
uniprot id: A0A5F9C213
uniprot id: G1THH3
names: Similarity
messages: Belongs to the AKAP110 family.

9986:LOC100348074
gene id: 9986:LOC100348074
uniprot id: A0A5F9D8R1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:LOC100349491
gene id: 9986:LOC100349491
uniprot id: G1TYG9
names: Similarity
messages: Belongs to the MAGUK family.

9986:LOC100353620
gene id: 9986:LOC100353620
uniprot id: G1SJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9986:LOC100345421
gene id: 9986:LOC100345421
uniprot id: G1SS47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100342029
gene id: 9986:LOC100342029
uniprot id: G1SI99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100351899
gene id: 9986:LOC100351899
uniprot id: A0A5F9DE24
uniprot id: G1SUL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9986:LOC100347467
gene id: 9986:LOC100347467
uniprot id: G1SW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9986:LOC100350730
gene id: 9986:LOC100350730
uniprot id: U3KPF0
names: Similarity
messages: Belongs to the copine family.

9986:LOC100346543
gene id: 9986:LOC100346543
uniprot id: G1T925
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9986:ORYCUNV1R1593
gene id: 9986:ORYCUNV1R1593
uniprot id: A0A5F9CCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344727
gene id: 9986:LOC100344727
uniprot id: G1T3T2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9986:LOC100351155
gene id: 9986:LOC100351155
uniprot id: G1T4S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100347515
gene id: 9986:LOC100347515
uniprot id: A0A5F9CEX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9986:LOC100354666
gene id: 9986:LOC100354666
uniprot id: G1TA26
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9986:LOC100348230
gene id: 9986:LOC100348230
uniprot id: G1SRG3
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9986:LOC100351343
gene id: 9986:LOC100351343
uniprot id: G1SDS5
names: Subcellular Location Annotation
messages: Membrane

9986:CSNK2B
gene id: 9986:CSNK2B
uniprot id: P67873
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity). Interacts with DYNLT2. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity).
messages: Phosphorylated by alpha subunit. Also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity).
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling (By similarity).

9986:LOC100356812
gene id: 9986:LOC100356812
uniprot id: G1SRV1
uniprot id: G1U3G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9986:LOC100345190
gene id: 9986:LOC100345190
uniprot id: A0A5F9D4Q9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100355204
gene id: 9986:LOC100355204
uniprot id: A0A5F9D2U2
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9986:LOC100347724
gene id: 9986:LOC100347724
uniprot id: A0A5F9DV82
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9986:SARS1
gene id: 9986:SARS1
uniprot id: G1SVJ5
uniprot id: P13642
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule may bind across the dimer. Interacts with SIRT2. Interacts with METTL6; interaction is required for the tRNA N(3)-methylcytidine methyltransferase activity of METTL6.
messages: Nucleus
messages: Was originally thought to function in mRNA expression.

9986:DES
gene id: 9986:DES
uniprot id: B7NZH1
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100346603
gene id: 9986:LOC100346603
uniprot id: G1TGT5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100345266
gene id: 9986:LOC100345266
uniprot id: G1T4S7
names: Similarity
messages: Belongs to the CWF19 family.

9986:LOC100354941
gene id: 9986:LOC100354941
uniprot id: A0A5F9DB00
uniprot id: G1SZR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:HPX
gene id: 9986:HPX
uniprot id: P20058
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted
messages: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear.

9986:LOC100338157
gene id: 9986:LOC100338157
uniprot id: A0A5F9C5W7
uniprot id: G1TLF6
names: Similarity
messages: Belongs to the AP-2 family.

9986:LOC100339272
gene id: 9986:LOC100339272
uniprot id: G1SXA9
names: Similarity
messages: Belongs to the BEX family.

9986:LOC100344759
gene id: 9986:LOC100344759
uniprot id: G1U2J0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100339583
gene id: 9986:LOC100339583
uniprot id: G1SZV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9986:LOC100343028
gene id: 9986:LOC100343028
uniprot id: G1SXK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9986:LOC100352010
gene id: 9986:LOC100352010
uniprot id: G1SZJ5
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9986:LOC100357301
gene id: 9986:LOC100357301
uniprot id: G1TR00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9986:LOC100355558
gene id: 9986:LOC100355558
uniprot id: G1SCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9986:LOC100350002
gene id: 9986:LOC100350002
uniprot id: G1SL20
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9986:LOC100359243
gene id: 9986:LOC100359243
uniprot id: G1T771
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9986:LOC100008932
gene id: 9986:LOC100008932
uniprot id: G1SZ55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100356088
gene id: 9986:LOC100356088
uniprot id: G1TJ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358719
gene id: 9986:LOC100358719
uniprot id: G1U771
names: Subunit
messages: Interacts with hair keratins.

9986:LOC100340384
gene id: 9986:LOC100340384
uniprot id: G1SUS6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9986:LOC100342692
gene id: 9986:LOC100342692
uniprot id: G1SU78
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9986:LOC100349183
gene id: 9986:LOC100349183
uniprot id: G1TID0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9986:LOC100351409
gene id: 9986:LOC100351409
uniprot id: G1SGI7
names: Similarity
messages: Belongs to the AKAP110 family.

9986:LOC100338055
gene id: 9986:LOC100338055
uniprot id: U3KM68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100356835
gene id: 9986:LOC100356835
uniprot id: A0A5F9DMZ2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9986:CX3CR1
gene id: 9986:CX3CR1
uniprot id: Q2KTE1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction …
messages: This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

9986:LOC108177333
gene id: 9986:LOC108177333
uniprot id: G1U0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345873
gene id: 9986:LOC100345873
uniprot id: A0A5F9DAG6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100347999
gene id: 9986:LOC100347999
uniprot id: G1U4X0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340152
gene id: 9986:LOC100340152
uniprot id: G1SGM3
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9986:LOC100342998
gene id: 9986:LOC100342998
uniprot id: G1SN04
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9986:LOC100347422
gene id: 9986:LOC100347422
uniprot id: G1SQE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9986:LOC100337724
gene id: 9986:LOC100337724
uniprot id: G1TTI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100341981
gene id: 9986:LOC100341981
uniprot id: G1SX32
names: Similarity
messages: Belongs to the PPP phosphatase family.

9986:LOC100355124
gene id: 9986:LOC100355124
uniprot id: G1SX77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9986:LOC100349698
gene id: 9986:LOC100349698
uniprot id: G1T724
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9986:HTR1D
gene id: 9986:HTR1D
uniprot id: P49145
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity).
messages: Homodimer. Heterodimer with HTR1B (By similarity).

9986:LOC100353309
gene id: 9986:LOC100353309
uniprot id: G1TM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC103351683
gene id: 9986:LOC103351683
uniprot id: G1T195
names: Similarity
messages: Belongs to the IFT43 family.

9986:LOC100347507
gene id: 9986:LOC100347507
uniprot id: G1T5M1
uniprot id: U3KPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9986:LOC100342147
gene id: 9986:LOC100342147
uniprot id: G1TCB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9986:LOC100347001
gene id: 9986:LOC100347001
uniprot id: G1T264
names: Similarity
messages: Belongs to the Bcl-2 family.

9986:LOC100344730
gene id: 9986:LOC100344730
uniprot id: A0A5F9CLB1
uniprot id: A0A5F9D7T1
uniprot id: A0A5Q0V3F0
uniprot id: A0A5Q0V3G3
uniprot id: A0A5Q0V3T0
uniprot id: G1SH07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9986:LOC100350312
gene id: 9986:LOC100350312
uniprot id: G1SS89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9986:DNAAF6
gene id: 9986:DNAAF6
uniprot id: G1SIF9
names: Similarity
messages: Belongs to the PIH1 family.

9986:LOC100339205
gene id: 9986:LOC100339205
uniprot id: G1TV68
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9986:LOC100351199
gene id: 9986:LOC100351199
uniprot id: G1U266
names: Similarity
messages: Belongs to the complex I LYR family.

9986:LOC100343929
gene id: 9986:LOC100343929
uniprot id: G1TC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9986:LOC100355519
gene id: 9986:LOC100355519
uniprot id: G1SPV0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100338297
gene id: 9986:LOC100338297
uniprot id: G1TL43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SLC11A1
gene id: 9986:SLC11A1
uniprot id: A0A144KBT6
names: Similarity
messages: Belongs to the NRAMP family.

9986:LOC100356021
gene id: 9986:LOC100356021
uniprot id: G1TA64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9986:LOC100339634
gene id: 9986:LOC100339634
uniprot id: G1SFA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100358790
gene id: 9986:LOC100358790
uniprot id: G1SKT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100343417
gene id: 9986:LOC100343417
uniprot id: G1TSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9986:LOC100344397
gene id: 9986:LOC100344397
uniprot id: A0A5F9DVL1
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9986:LOC100357494
gene id: 9986:LOC100357494
uniprot id: G1SP42
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100344651
gene id: 9986:LOC100344651
uniprot id: A0A5F9CGF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9986:PTGS2
gene id: 9986:PTGS2
uniprot id: O02768
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated at Ser-565 by SPHK1. During neuroinflammation, acetylation by SPHK1 promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further …
messages: Endoplasmic reticulum membrane
messages: Highest expression in kidney and urinary bladder.
messages: Homodimer.
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.

9986:LOC100356438
gene id: 9986:LOC100356438
uniprot id: A0A5F9DUA4
uniprot id: G1T7U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9986:LOC100340827
gene id: 9986:LOC100340827
uniprot id: G1SS52
names: Similarity
messages: Belongs to the peptidase M14 family.

9986:LOC100348712
gene id: 9986:LOC100348712
uniprot id: A0A5F9CT71
uniprot id: G1SEP5
names: Similarity
messages: Belongs to the angiomotin family.

9986:LOC100350402
gene id: 9986:LOC100350402
uniprot id: G1SP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9986:LOC100346986
gene id: 9986:LOC100346986
uniprot id: G1SL49
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9986:LOC100342984
gene id: 9986:LOC100342984
uniprot id: G1TWH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9986:LOC100358327
gene id: 9986:LOC100358327
uniprot id: A0A5F9CYD6
uniprot id: G1SMB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9986:ODAD4
gene id: 9986:ODAD4
uniprot id: G1T507
names: Subcellular Location Annotation
messages: cilium axoneme

9986:AMHR2
gene id: 9986:AMHR2
uniprot id: Q28616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Interacts with type I receptor ACVR1.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9986:LOC100346297
gene id: 9986:LOC100346297
uniprot id: A0A5F9CCQ2
names: Subcellular Location Annotation
messages: Nucleus

9986:NPC1L1
gene id: 9986:NPC1L1
uniprot id: A0MJA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9986:LOC100338481
gene id: 9986:LOC100338481
uniprot id: G1U7S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9986:TXNRD3
gene id: 9986:TXNRD3
uniprot id: G1SW84
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9986:LOC100339370
gene id: 9986:LOC100339370
uniprot id: G1TXM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353580
gene id: 9986:LOC100353580
uniprot id: G1T6Y7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100358225
gene id: 9986:LOC100358225
uniprot id: G1TAB0
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100354731
gene id: 9986:LOC100354731
uniprot id: G1TP92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9986:CXCR1
gene id: 9986:CXCR1
uniprot id: P21109
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with IL8. Interacts with GNAI2.
messages: Neutrophils.
messages: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
messages: Was originally thought to be the receptor for fMet-Leu-Phe (N-formyl peptide receptor).

9986:LOC100345332
gene id: 9986:LOC100345332
uniprot id: A0A5F9DW00
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100337945
gene id: 9986:LOC100337945
uniprot id: G1SRY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SCNM1
gene id: 9986:SCNM1
uniprot id: B7NZC9
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9986:LOC100351947
gene id: 9986:LOC100351947
uniprot id: G1TUY4
names: Similarity
messages: Belongs to the MOG1 family.

9986:LOC100345516
gene id: 9986:LOC100345516
uniprot id: A0A5F9DIW1
uniprot id: G1T287
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100353903
gene id: 9986:LOC100353903
uniprot id: G1TPM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345430
gene id: 9986:LOC100345430
uniprot id: G1TWC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9986:STEAP1
gene id: 9986:STEAP1
uniprot id: B6A7P8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353055
gene id: 9986:LOC100353055
uniprot id: G1T131
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9986:CACNB3
gene id: 9986:CACNB3
uniprot id: P54286
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel beta subunit family.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1 (PubMed:1312465). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio. Interacts with CACNA2D4. Interacts with FASLG (By similarity). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (By similarity).
messages: Cytoplasm
messages: Most abundant in brain but also present in aorta, trachea and lung.
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:1312465). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).

9986:LOC100352022
gene id: 9986:LOC100352022
uniprot id: G1SEX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100351446
gene id: 9986:LOC100351446
uniprot id: G1T3M2
names: Subcellular Location Annotation
messages: centrosome

9986:FMO1
gene id: 9986:FMO1
uniprot id: P17636
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (By similarity). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).
messages: Endoplasmic reticulum membrane
messages: Liver.

9986:LOC100356974
gene id: 9986:LOC100356974
uniprot id: G1TXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9986:LOC100348237
gene id: 9986:LOC100348237
uniprot id: A0A5F9CZ88
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100357416
gene id: 9986:LOC100357416
uniprot id: G1SFU5
names: Similarity
messages: Belongs to the cyclin family.

9986:LOC100343987
gene id: 9986:LOC100343987
uniprot id: G1T178
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100353942
gene id: 9986:LOC100353942
uniprot id: G1SET0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9986:LOC100347933
gene id: 9986:LOC100347933
uniprot id: G1TY16
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

9986:LOC100349983
gene id: 9986:LOC100349983
uniprot id: G1SUT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9986:LOC100352083
gene id: 9986:LOC100352083
uniprot id: G1TNP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352691
gene id: 9986:LOC100352691
uniprot id: A0A5F9DR33
uniprot id: A0A5F9DVX2
uniprot id: G1SZ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9986:LOC100340275
gene id: 9986:LOC100340275
uniprot id: G1T6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9986:LOC100351951
gene id: 9986:LOC100351951
uniprot id: G1U211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100355650
gene id: 9986:LOC100355650
uniprot id: G1TA47
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9986:LOC100339921
gene id: 9986:LOC100339921
uniprot id: G1TB89
names: Similarity
messages: Belongs to the DDIT4 family.

9986:LOC100358851
gene id: 9986:LOC100358851
uniprot id: G1T1R0
names: Similarity
messages: Belongs to the PRORSD1 family.

9986:LOC100355049
gene id: 9986:LOC100355049
uniprot id: U3KPD5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9986:UBA1
gene id: 9986:UBA1
uniprot id: Q29504
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-activating E1 family.
messages: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:9322736). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.
messages: Nucleus
messages: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.
messages: Ubiquitous.

9986:HOXA7
gene id: 9986:HOXA7
uniprot id: B7NZT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100350145
gene id: 9986:LOC100350145
uniprot id: G1TUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345064
gene id: 9986:LOC100345064
uniprot id: A0A5F9D8J4
uniprot id: G1T8X2
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346623
gene id: 9986:LOC100346623
uniprot id: G1SES9
names: Similarity
messages: Belongs to the PurH family.

9986:LOC100344592
gene id: 9986:LOC100344592
uniprot id: G1U7P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343228
gene id: 9986:LOC100343228
uniprot id: A0A5F9CWZ1
names: Subcellular Location Annotation
messages: Nucleus

9986:NPM1
gene id: 9986:NPM1
uniprot id: B7NZF9
names: Similarity
messages: Belongs to the nucleoplasmin family.

9986:KEF51 p03
gene id: 9986:KEF51_p03
uniprot id: A0A3S8V6Y5
uniprot id: O79437
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100338777
gene id: 9986:LOC100338777
uniprot id: G1SVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9986:ORYCUNV1R1512
gene id: 9986:ORYCUNV1R1512
uniprot id: G1U6H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347976
gene id: 9986:LOC100347976
uniprot id: G1T929
uniprot id: U3KLZ0
names: Similarity
messages: Belongs to the IFRD family.

9986:IRF1
gene id: 9986:IRF1
uniprot id: B7NZL0
uniprot id: G1SL77
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:HYCC1
gene id: 9986:HYCC1
uniprot id: A0A5F9D503
uniprot id: A0A5F9D8C9
uniprot id: G1SR93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9986:LOC100358770
gene id: 9986:LOC100358770
uniprot id: A0A5F9CAN8
uniprot id: A0A5F9DGP2
uniprot id: A0A5F9DLW3
names: Similarity
messages: Belongs to the LEM family.

9986:ROMO1
gene id: 9986:ROMO1
uniprot id: B7NZJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9986:LOC100341454
gene id: 9986:LOC100341454
uniprot id: G1STN3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9986:LOC100356375
gene id: 9986:LOC100356375
uniprot id: G1U924
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100338214
gene id: 9986:LOC100338214
uniprot id: A0A5F9DVU2
names: Similarity
messages: Belongs to the hexokinase family.

9986:LOC100359077
gene id: 9986:LOC100359077
uniprot id: U3KPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9986:LOC100340249
gene id: 9986:LOC100340249
uniprot id: G1TQJ4
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9986:LOC100344028
gene id: 9986:LOC100344028
uniprot id: G1T386
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9986:MINDY2
gene id: 9986:MINDY2
uniprot id: A0A5F9D690
uniprot id: G1TJJ0
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9986:LOC100338973
gene id: 9986:LOC100338973
uniprot id: G1TDL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9986:IL6
gene id: 9986:IL6
uniprot id: Q9MZR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: Secreted

9986:LOC100344387
gene id: 9986:LOC100344387
uniprot id: G1SWE0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100344197
gene id: 9986:LOC100344197
uniprot id: G1TC81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9986:LOC100350401
gene id: 9986:LOC100350401
uniprot id: G1SZ44
names: Similarity
messages: Belongs to the GroES chaperonin family.

9986:EIF4G1
gene id: 9986:EIF4G1
uniprot id: A0A5F9CH69
uniprot id: G1SQD1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9986:LOC100357314
gene id: 9986:LOC100357314
uniprot id: G1TTY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100343598
gene id: 9986:LOC100343598
uniprot id: G1SUY1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:RAF2
gene id: 9986:RAF2
uniprot id: G1U1L3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:HTR1A
gene id: 9986:HTR1A
uniprot id: G1SXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

9986:LOC100358373
gene id: 9986:LOC100358373
uniprot id: G1T556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9986:LOC100340844
gene id: 9986:LOC100340844
uniprot id: A0A5F9DMK4
names: Similarity
messages: Belongs to the TMEM14 family.

9986:LOC100355082
gene id: 9986:LOC100355082
uniprot id: G1U3N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9986:LOC100351097
gene id: 9986:LOC100351097
uniprot id: A0A5F9CSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9986:LOC100347981
gene id: 9986:LOC100347981
uniprot id: G1T2L5
names: Similarity
messages: Belongs to the complex I LYR family.

9986:LOC100356678
gene id: 9986:LOC100356678
uniprot id: A0A7R8GUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100359327
gene id: 9986:LOC100359327
uniprot id: A0A654ICS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:LOC100349504
gene id: 9986:LOC100349504
uniprot id: G1T179
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100350237
gene id: 9986:LOC100350237
uniprot id: G1SYX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9986:LOC100350757
gene id: 9986:LOC100350757
uniprot id: G1SVM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9986:LOC100344036
gene id: 9986:LOC100344036
uniprot id: G1TIX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

9986:KCNA3
gene id: 9986:KCNA3
uniprot id: Q28656
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343050
gene id: 9986:LOC100343050
uniprot id: G1U458
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:LOC100351999
gene id: 9986:LOC100351999
uniprot id: A0A5F9CVN3
uniprot id: G1SNW9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100356720
gene id: 9986:LOC100356720
uniprot id: G1SGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9986:GPX7
gene id: 9986:GPX7
uniprot id: G1SST7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9986:PGC
gene id: 9986:PGC
uniprot id: Q9GMY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.
messages: Secreted

9986:LOC100346745
gene id: 9986:LOC100346745
uniprot id: U3KP85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9986:LOC100358087
gene id: 9986:LOC100358087
uniprot id: G1SEP0
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9986:LOC100352518
gene id: 9986:LOC100352518
uniprot id: G1SDH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9986:CALM2
gene id: 9986:CALM2
uniprot id: P62160
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.
messages: Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). Interacts with HINT1; interaction increases in the presence of calcium ions (By similarity). Interacts with HINT3 (By similarity).
messages: Phosphorylation results in a decreased activity.
messages: The N-terminus is blocked.
messages: This protein has four functional calcium-binding sites.
messages: Ubiquitination results in a strongly decreased activity.
messages: spindle
messages: spindle pole

9986:LOC100338581
gene id: 9986:LOC100338581
uniprot id: G1TEN1
names: Similarity
messages: Belongs to the actin family.

9986:OR52R1
gene id: 9986:OR52R1
uniprot id: B8K148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358158
gene id: 9986:LOC100358158
uniprot id: A0A5F9DIU1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9986:LOC103349698
gene id: 9986:LOC103349698
uniprot id: G1T700
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9986:LOC108177601
gene id: 9986:LOC108177601
uniprot id: G1TEZ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9986:LOC100008806
gene id: 9986:LOC100008806
uniprot id: G1SZE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9986:RAD50
gene id: 9986:RAD50
uniprot id: B7NZL1
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9986:LOC100355536
gene id: 9986:LOC100355536
uniprot id: G1SV59
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9986:LOC100345179
gene id: 9986:LOC100345179
uniprot id: G1SVP2
names: Similarity
messages: Belongs to the TMCO4 family.

9986:LOC103351718
gene id: 9986:LOC103351718
uniprot id: G1TQU2
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9986:LOC100341458
gene id: 9986:LOC100341458
uniprot id: G1SPM5
names: Similarity
messages: Belongs to the actin family.

9986:LOC100342228
gene id: 9986:LOC100342228
uniprot id: G1T1S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100340670
gene id: 9986:LOC100340670
uniprot id: G1SMV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm

9986:SELP
gene id: 9986:SELP
uniprot id: G1TBQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:ORM1
gene id: 9986:ORM1
uniprot id: P25227
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Contains a beta-barrel that binds various ligands in its interior.
messages: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
messages: Secreted

9986:LOC100353794
gene id: 9986:LOC100353794
uniprot id: G1SD91
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9986:PPP2R2B
gene id: 9986:PPP2R2B
uniprot id: A0A5F9C5L3
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9986:LOC100340151
gene id: 9986:LOC100340151
uniprot id: G1SU86
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100349253
gene id: 9986:LOC100349253
uniprot id: G1SCI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9986:LOC100355852
gene id: 9986:LOC100355852
uniprot id: G1SYT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9986:LOC100353038
gene id: 9986:LOC100353038
uniprot id: G1U4S9
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9986:LOC100338092
gene id: 9986:LOC100338092
uniprot id: A0A5F9CJA6
uniprot id: G1SFP5
names: Similarity
messages: Belongs to the SIN1 family.

9986:LOC100348263
gene id: 9986:LOC100348263
uniprot id: G1SX93
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9986:LOC100342023
gene id: 9986:LOC100342023
uniprot id: G1SCG8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354680
gene id: 9986:LOC100354680
uniprot id: A0A5F9CHJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9986:LOC100358661
gene id: 9986:LOC100358661
uniprot id: G1SLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9986:LOC100347254
gene id: 9986:LOC100347254
uniprot id: G1TUU8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9986:SNTA1
gene id: 9986:SNTA1
uniprot id: Q28626
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: Highly expressed in skeletal and cardiac muscle and is also detected in brain.
messages: Monomer and homodimer. Interacts with the dystrophin related protein DTNA; SGCG of the dystrophin glycoprotein complex; NOS1; GRB2; GA; TGFA; MAPK12 and the sodium channel proteins SCN4A and SCN5A (By similarity). Interacts with the dystrophin protein DMD in a calmodulin dependent manner and with related protein UTRN; SGCA of the dystrophin glycoprotein complex; F-actin; calmodulin and with the other members of the syntrophin family SNTB1 and SNTB2. Interacts with MYOC; regulates muscle hypertrophy (By similarity). Interacts with DTNB (By similarity).
messages: Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).
messages: The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).
messages: The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.
messages: The SU domain binds calmodulin in a calcium-dependent manner (By similarity). It contains actin-binding sites.
messages: cytoskeleton
messages: sarcolemma

9986:LOC100348171
gene id: 9986:LOC100348171
uniprot id: G1TCN5
names: Similarity
messages: Belongs to the FAM25 family.

9986:LOC100339977
gene id: 9986:LOC100339977
uniprot id: G1SQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9986:LOC100347468
gene id: 9986:LOC100347468
uniprot id: G1TRM4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9986:LOC100353097
gene id: 9986:LOC100353097
uniprot id: G1SRT1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9986:LOC100101621
gene id: 9986:LOC100101621
uniprot id: G1T180
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:LOC100347338
gene id: 9986:LOC100347338
uniprot id: G1SWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9986:LOC100352587
gene id: 9986:LOC100352587
uniprot id: G1SJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9986:LOC100347757
gene id: 9986:LOC100347757
uniprot id: G1SSH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9986:LOC108175356
gene id: 9986:LOC108175356
uniprot id: G1T2L3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9986:LOC100350188
gene id: 9986:LOC100350188
uniprot id: G1SGU8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100356816
gene id: 9986:LOC100356816
uniprot id: G1SKJ0
uniprot id: U3KM52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100352420
gene id: 9986:LOC100352420
uniprot id: G1SGL6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100358785
gene id: 9986:LOC100358785
uniprot id: A0A5F9D416
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100340047
gene id: 9986:LOC100340047
uniprot id: A0A5F9DIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348388
gene id: 9986:LOC100348388
uniprot id: G1SPP3
names: Similarity
messages: Belongs to the intermediate filament family.

9986:TES
gene id: 9986:TES
uniprot id: Q09YN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9986:LOC100354934
gene id: 9986:LOC100354934
uniprot id: G1SSZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9986:LOC100341277
gene id: 9986:LOC100341277
uniprot id: A0A5F9D1Y3
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100346627
gene id: 9986:LOC100346627
uniprot id: G1SVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9986:CATSPERE
gene id: 9986:CATSPERE
uniprot id: G1T3J7
names: Similarity
messages: Belongs to the CATSPERD family.

9986:PRRX1
gene id: 9986:PRRX1
uniprot id: A0A076JUR3
uniprot id: A0A0H4M7H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9986:NXPE1
gene id: 9986:NXPE1
uniprot id: Q05004
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NXPE family.
messages: Expressed in the intestine of adult but not baby rabbits.
messages: Intestine, and to a lesser extent in kidney.
messages: Secreted

9986:ADAM1A
gene id: 9986:ADAM1A
uniprot id: Q28659
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100358196
gene id: 9986:LOC100358196
uniprot id: G1T440
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9986:LOC100338324
gene id: 9986:LOC100338324
uniprot id: A0A5F9CAG7
uniprot id: U3KPG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9986:LOC100352863
gene id: 9986:LOC100352863
uniprot id: G1SIH0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100352098
gene id: 9986:LOC100352098
uniprot id: G1SXI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9986:LOC100354613
gene id: 9986:LOC100354613
uniprot id: G1TYG2
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9986:LOC100356348
gene id: 9986:LOC100356348
uniprot id: A0A5F9CH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9986:LOC100352536
gene id: 9986:LOC100352536
uniprot id: G1U437
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9986:SCNN1A
gene id: 9986:SCNN1A
uniprot id: O97741
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. Interacts with NEDD4 (via WW domains). Interacts with NEDD4L (via WW domains). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9).
messages: N-glycosylated.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
messages: Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.
messages: acrosome
messages: cilium
messages: flagellum

9986:LOC100341363
gene id: 9986:LOC100341363
uniprot id: G1SRP1
names: Similarity
messages: Belongs to the FAM102 family.

9986:LOC100353958
gene id: 9986:LOC100353958
uniprot id: G1SII3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9986:LOC100009015
gene id: 9986:LOC100009015
uniprot id: G1SCM4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346643
gene id: 9986:LOC100346643
uniprot id: G1SSM2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9986:LOC100353718
gene id: 9986:LOC100353718
uniprot id: G1SJ94
names: Subcellular Location Annotation
messages: Membrane

9986:EIF4G2
gene id: 9986:EIF4G2
uniprot id: P79398
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
messages: Belongs to the eukaryotic initiation factor 4G family.
messages: Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD (By similarity). Interacts with DAZAP2 (By similarity).
messages: Phosphorylation; hyperphosphorylated during mitosis.
messages: This gene has been shown to be extensively edited in the liver of APOBEC1 transgenic animals. Its aberrant editing could contribute to the potent oncogenesis induced by overexpression of APOBEC1. The aberrant edited sequence, called NAT1, is likely to be a fundamental translational repressor.

9986:LOC100338040
gene id: 9986:LOC100338040
uniprot id: G1TNG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346767
gene id: 9986:LOC100346767
uniprot id: G1SXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9986:LOC100355868
gene id: 9986:LOC100355868
uniprot id: A0A5F9CBT7
uniprot id: A0A5F9D2V8
uniprot id: A0A5F9D8Y9
uniprot id: A0A5F9DI01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9986:LOC100349024
gene id: 9986:LOC100349024
uniprot id: G1SLY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
messages: Membrane

9986:LOC100339550
gene id: 9986:LOC100339550
uniprot id: G1SYG5
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9986:LOC100354888
gene id: 9986:LOC100354888
uniprot id: A0A5F9CIC1
names: Similarity
messages: Belongs to the RUTBC family.

9986:LOC100342639
gene id: 9986:LOC100342639
uniprot id: G1T2G8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9986:TPD52
gene id: 9986:TPD52
uniprot id: Q95212
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the TPD52 family.
messages: Forms a homodimer or heterodimer with other members of the family.
messages: Phosphorylated in a calcium/calmodulin-dependent manner.

9986:CFAP300
gene id: 9986:CFAP300
uniprot id: A0A5F9CLE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9986:LOC100338397
gene id: 9986:LOC100338397
uniprot id: A0A5F9C2W8
uniprot id: G1T4H6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9986:LOC100357597
gene id: 9986:LOC100357597
uniprot id: G1ST72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:RHO
gene id: 9986:RHO
uniprot id: A0A5S8HJ78
uniprot id: P49912
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
messages: Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG. Interacts with GNAT1. Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
messages: photoreceptor outer segment

9986:LOC100356958
gene id: 9986:LOC100356958
uniprot id: G1T9Y0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100352242
gene id: 9986:LOC100352242
uniprot id: G1TP04
names: Subcellular Location Annotation
messages: Membrane

9986:OR51E1
gene id: 9986:OR51E1
uniprot id: B8K137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355421
gene id: 9986:LOC100355421
uniprot id: G1SI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100351138
gene id: 9986:LOC100351138
uniprot id: G1SKD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9986:KIFBP
gene id: 9986:KIFBP
uniprot id: A0A5F9D285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9986:AKR1B10
gene id: 9986:AKR1B10
uniprot id: I4DEZ5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9986:LOC100349063
gene id: 9986:LOC100349063
uniprot id: A0A5F9CMI1
uniprot id: A0A5F9CV55
uniprot id: A0A5F9DRW6
uniprot id: U3KMN1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC103347681
gene id: 9986:LOC103347681
uniprot id: A0A0A0MQQ1
names: Similarity
messages: Belongs to the acylphosphatase family.

9986:LOC100342956
gene id: 9986:LOC100342956
uniprot id: G1TE50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9986:TAC1
gene id: 9986:TAC1
uniprot id: G1SQH8
uniprot id: P41540
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
messages: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).

9986:LOC100355059
gene id: 9986:LOC100355059
uniprot id: G1T876
names: Similarity
messages: Belongs to the FAM76 family.

9986:LOC100355062
gene id: 9986:LOC100355062
uniprot id: G1TC37
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9986:LOC103349007
gene id: 9986:LOC103349007
uniprot id: G1T1K9
names: Similarity
messages: Belongs to the DCP1 family.

9986:LOC100338182
gene id: 9986:LOC100338182
uniprot id: A0A5F9DGB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100353280
gene id: 9986:LOC100353280
uniprot id: A0A5F9DJN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9986:LOC100346565
gene id: 9986:LOC100346565
uniprot id: G1SPJ6
names: Similarity
messages: Belongs to the peptidase C13 family.

9986:CAV1
gene id: 9986:CAV1
uniprot id: Q09YN6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9986:LOC100352184
gene id: 9986:LOC100352184
uniprot id: A0A5F9D5I1
uniprot id: G1T123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

9986:LOC100349393
gene id: 9986:LOC100349393
uniprot id: G1SFD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100008985
gene id: 9986:LOC100008985
uniprot id: G1SXG6
names: Similarity
messages: Belongs to the S-100 family.

9986:LOC100357452
gene id: 9986:LOC100357452
uniprot id: A0A7R8C502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100357974
gene id: 9986:LOC100357974
uniprot id: G1SMR8
names: Similarity
messages: Belongs to the UPF0046 family.

9986:LOC100341557
gene id: 9986:LOC100341557
uniprot id: G1T024
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9986:LOC100342874
gene id: 9986:LOC100342874
uniprot id: G1TRF8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350438
gene id: 9986:LOC100350438
uniprot id: A0A5F9D1Y6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100009374
gene id: 9986:LOC100009374
uniprot id: G1SHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9986:EIF4EBP3
gene id: 9986:EIF4EBP3
uniprot id: A0A5F9CHY6
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9986:KCNA4
gene id: 9986:KCNA4
uniprot id: A0A5F9DU12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9986:C2H2orf49
gene id: 9986:C2H2orf49
uniprot id: A0A5F9D032
uniprot id: G1SU59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9986:STN1
gene id: 9986:STN1
uniprot id: G1SIW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9986:LOC100353598
gene id: 9986:LOC100353598
uniprot id: G1SWR2
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9986:LOC100346249
gene id: 9986:LOC100346249
uniprot id: G1SW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9986:LOC100338935
gene id: 9986:LOC100338935
uniprot id: G1U0K9
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100353000
gene id: 9986:LOC100353000
uniprot id: G1U9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9986:LOC100357111
gene id: 9986:LOC100357111
uniprot id: G1TU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9986:LOC100348425
gene id: 9986:LOC100348425
uniprot id: G1T6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9986:OLFR656
gene id: 9986:OLFR656
uniprot id: B8K1A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339652
gene id: 9986:LOC100339652
uniprot id: G1T1E1
names: Similarity
messages: Belongs to the unc-5 family.

9986:LOC100356913
gene id: 9986:LOC100356913
uniprot id: G1SZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
messages: acrosome membrane

9986:TNF
gene id: 9986:TNF
uniprot id: A0A0U5CJJ9
uniprot id: A0A5S8H7U2
uniprot id: P04924
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9986:LOC100344318
gene id: 9986:LOC100344318
uniprot id: G1SKR9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9986:LOC100351943
gene id: 9986:LOC100351943
uniprot id: G1T2H9
names: Function
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.

9986:LOC100357205
gene id: 9986:LOC100357205
uniprot id: G1T736
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9986:LOC100343439
gene id: 9986:LOC100343439
uniprot id: G1SWH2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100352259
gene id: 9986:LOC100352259
uniprot id: A0A5F9CYP0
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9986:LOC103345122
gene id: 9986:LOC103345122
uniprot id: G1SW68
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100341338
gene id: 9986:LOC100341338
uniprot id: G1U8I8
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9986:LOC100346951
gene id: 9986:LOC100346951
uniprot id: G1T2I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

9986:RAB11A
gene id: 9986:RAB11A
uniprot id: P62493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A prominent expression is seen in gastric parietal cells.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with RAB11FIP5 (By similarity). Interacts with STXBP6 (By similarity). Interacts (GDP-bound form) with ZFYVE27 (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (By similarity). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with TBC1D12 (By similarity). Interacts with DEF6 (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity).
messages: phagosome

9986:LOC100355056
gene id: 9986:LOC100355056
uniprot id: G1T8G9
names: Similarity
messages: Belongs to the pyruvate kinase family.

9986:LOC100356381
gene id: 9986:LOC100356381
uniprot id: G1T595
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC108175401
gene id: 9986:LOC108175401
uniprot id: G1TZX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9986:LOC100341954
gene id: 9986:LOC100341954
uniprot id: A0A5F9DCT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100356638
gene id: 9986:LOC100356638
uniprot id: G1TZ76
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:PDZK1
gene id: 9986:PDZK1
uniprot id: Q865P3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
messages: Belongs to the NHER family.
messages: Cell membrane
messages: Highly expressed in the brush border membrane of duodenal and ileal mucosa.
messages: Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains.
messages: Interacts with PDZK1IP1 and ABCC2. Interacts (via PDZ domains 1 and 3) with SCARB1 (C-terminal domain). Forms a heterodimeric complex with SLC9A3R1. Interacts with AKAP2, BCR, CFTR, SLCO1A1, SLC22A12, SLC22A4, SLC22A5, SLC9A3R2 and SLC17A1. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts (via C-terminal PDZ domain) with SLC9A3 (via C-terminal domain). Interacts (via the first PDZ domain) with PTGIR (via non-isoprenylated C-terminus) (By similarity). Binds to the C-terminal region of SLC26A3. Interacts (via C-terminal PDZ domain) with SLC26A6 (via C-terminal domain).
messages: Membrane
messages: The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1.
messages: The PDZ 1 domain interacts with BCR.
messages: The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.
messages: The PDZ 2 and 4 domains do not interact with the C-terminal region of SCARB1.

9986:LOC100340585
gene id: 9986:LOC100340585
uniprot id: G1T004
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

9986:LOC100355169
gene id: 9986:LOC100355169
uniprot id: G1U0W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9986:LOC100342311
gene id: 9986:LOC100342311
uniprot id: G1SG69
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9986:ITIH2
gene id: 9986:ITIH2
uniprot id: Q9GLY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9986:LOC100339295
gene id: 9986:LOC100339295
uniprot id: G1T995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9986:LOC100355552
gene id: 9986:LOC100355552
uniprot id: G1SFL4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100356882
gene id: 9986:LOC100356882
uniprot id: G1SMV3
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354018
gene id: 9986:LOC100354018
uniprot id: G1U5M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC100340814
gene id: 9986:LOC100340814
uniprot id: G1TUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350282
gene id: 9986:LOC100350282
uniprot id: A0A2Z6DUF7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100347239
gene id: 9986:LOC100347239
uniprot id: G1TP83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100351268
gene id: 9986:LOC100351268
uniprot id: G1SEK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352384
gene id: 9986:LOC100352384
uniprot id: G1SU49
names: Similarity
messages: Belongs to the MS4A family.

9986:LOC100352824
gene id: 9986:LOC100352824
uniprot id: G1T6P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9986:LOC100342946
gene id: 9986:LOC100342946
uniprot id: A0A5F9CCI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9986:LOC100358940
gene id: 9986:LOC100358940
uniprot id: G1T0T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9986:LOC100348334
gene id: 9986:LOC100348334
uniprot id: A0A5F9CY16
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9986:POGLUT2
gene id: 9986:POGLUT2
uniprot id: G1SHJ3
names: Similarity
messages: Belongs to the KDELC family.

9986:LOC103351698
gene id: 9986:LOC103351698
uniprot id: G1T656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100101608
gene id: 9986:LOC100101608
uniprot id: A0A5F9CDG1
uniprot id: A0A5F9CNH9
uniprot id: G1U463
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100351174
gene id: 9986:LOC100351174
uniprot id: A0A5F9CF86
uniprot id: G1TKP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100344754
gene id: 9986:LOC100344754
uniprot id: G1U9P7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343539
gene id: 9986:LOC100343539
uniprot id: G1SIQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352230
gene id: 9986:LOC100352230
uniprot id: G1TJ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343664
gene id: 9986:LOC100343664
uniprot id: A0A5F9C9T0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9986:TRIM6
gene id: 9986:TRIM6
uniprot id: B8K1A1
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100342822
gene id: 9986:LOC100342822
uniprot id: A0A5F9D3P6
uniprot id: G1SQL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9986:LOC100338249
gene id: 9986:LOC100338249
uniprot id: G1SYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9986:LOC100356543
gene id: 9986:LOC100356543
uniprot id: G1TQN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349027
gene id: 9986:LOC100349027
uniprot id: G1SLI0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9986:LOC100354000
gene id: 9986:LOC100354000
uniprot id: G1TLQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100353979
gene id: 9986:LOC100353979
uniprot id: G1SIP9
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9986:CSN1S2
gene id: 9986:CSN1S2
uniprot id: P50419
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9986:DIO2
gene id: 9986:DIO2
uniprot id: A4GNS7
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

9986:LOC100356383
gene id: 9986:LOC100356383
uniprot id: G1T0C1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9986:LOC100348873
gene id: 9986:LOC100348873
uniprot id: G1T9M9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9986:LOC100350880
gene id: 9986:LOC100350880
uniprot id: G1SPK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9986:LOC100342257
gene id: 9986:LOC100342257
uniprot id: G1T0B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9986:CSN2
gene id: 9986:CSN2
uniprot id: P09116
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9986:LOC100339588
gene id: 9986:LOC100339588
uniprot id: A0A5F9D100
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9986:EVX1
gene id: 9986:EVX1
uniprot id: B7NZU1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100101617
gene id: 9986:LOC100101617
uniprot id: G1SCK9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100348144
gene id: 9986:LOC100348144
uniprot id: G1T0M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

9986:LOC100345000
gene id: 9986:LOC100345000
uniprot id: G1T7G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9986:TENT5B
gene id: 9986:TENT5B
uniprot id: G1SQZ3
names: Similarity
messages: Belongs to the TENT family.

9986:LOC100347503
gene id: 9986:LOC100347503
uniprot id: G1STW4
names: Subcellular Location Annotation
messages: centrosome

9986:LOC100352744
gene id: 9986:LOC100352744
uniprot id: G1T0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9986:LOC100356017
gene id: 9986:LOC100356017
uniprot id: G1SP01
names: Similarity
messages: Belongs to the peptidase S9A family.

9986:ASF1A
gene id: 9986:ASF1A
uniprot id: B7NZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9986:LOC100343077
gene id: 9986:LOC100343077
uniprot id: G1SE09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347786
gene id: 9986:LOC100347786
uniprot id: G1TM85
names: Similarity
messages: Belongs to the NXPE family.

9986:LOC108178519
gene id: 9986:LOC108178519
uniprot id: G1TSY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100008720
gene id: 9986:LOC100008720
uniprot id: G1SH28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9986:LOC100352237
gene id: 9986:LOC100352237
uniprot id: G1TQL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100353356
gene id: 9986:LOC100353356
uniprot id: G1T193
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9986:LOC100354981
gene id: 9986:LOC100354981
uniprot id: G1SXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9986:LOC100348311
gene id: 9986:LOC100348311
uniprot id: G1TV39
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9986:LOC100343507
gene id: 9986:LOC100343507
uniprot id: G1SN13
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100343057
gene id: 9986:LOC100343057
uniprot id: G1TRL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9986:LOC100338134
gene id: 9986:LOC100338134
uniprot id: A0A5F9CJM2
uniprot id: G1SMY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9986:LOC100344162
gene id: 9986:LOC100344162
uniprot id: G1TTA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100347215
gene id: 9986:LOC100347215
uniprot id: G1SW44
uniprot id: U3KMU9
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9986:LOC100356820
gene id: 9986:LOC100356820
uniprot id: G1SED1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100351275
gene id: 9986:LOC100351275
uniprot id: G1T8L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9986:LOC100345677
gene id: 9986:LOC100345677
uniprot id: G1SUY7
uniprot id: G1U766
names: Similarity
messages: Belongs to the SIKE family.

9986:LOC100351242
gene id: 9986:LOC100351242
uniprot id: G1SH17
names: Similarity
messages: Belongs to the pleiotrophin family.

9986:LTBR
gene id: 9986:LTBR
uniprot id: G1SF49
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100345760
gene id: 9986:LOC100345760
uniprot id: A0A5F9DPQ9
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9986:LOC100345409
gene id: 9986:LOC100345409
uniprot id: U3KN10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9986:LOC100350465
gene id: 9986:LOC100350465
uniprot id: A0A5F9DNC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340499
gene id: 9986:LOC100340499
uniprot id: G1TQ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9986:LOC100345525
gene id: 9986:LOC100345525
uniprot id: G1SGE5
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9986:LOC100355534
gene id: 9986:LOC100355534
uniprot id: G1SVC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

9986:CD28
gene id: 9986:CD28
uniprot id: P42069
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2 (By similarity).
messages: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
messages: Membrane

9986:BCL2L1
gene id: 9986:BCL2L1
uniprot id: Q9MYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9986:LOC100144332
gene id: 9986:LOC100144332
uniprot id: A0A5F9CNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9986:LOC100345609
gene id: 9986:LOC100345609
uniprot id: G1TRM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:MYH3
gene id: 9986:MYH3
uniprot id: A0A5F9CYU6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:LOC100354315
gene id: 9986:LOC100354315
uniprot id: G1TWZ1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9986:LOC100352650
gene id: 9986:LOC100352650
uniprot id: A0A5F9C392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9986:LOC100358938
gene id: 9986:LOC100358938
uniprot id: G1T9Y6
names: Similarity
messages: Belongs to the cornifelin family.

9986:PROC
gene id: 9986:PROC
uniprot id: G1TAC0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100349232
gene id: 9986:LOC100349232
uniprot id: G1T752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9986:CCKAR
gene id: 9986:CCKAR
uniprot id: O97772
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

9986:LGALS3
gene id: 9986:LGALS3
uniprot id: P47845
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
messages: Nucleus
messages: Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, ZFTRAF1 and UACA. Interacts with TRIM16; this interaction mediates autophagy of damage endomembranes (By similarity).
messages: Secreted

9986:LOC100351433
gene id: 9986:LOC100351433
uniprot id: A0A5F9C7U0
uniprot id: G1SS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9986:LOC100346184
gene id: 9986:LOC100346184
uniprot id: G1SE19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9986:LOC100341813
gene id: 9986:LOC100341813
uniprot id: G1SM43
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9986:LOC100348714
gene id: 9986:LOC100348714
uniprot id: G1SLC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9986:LOC100351310
gene id: 9986:LOC100351310
uniprot id: A0A5F9DLX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339733
gene id: 9986:LOC100339733
uniprot id: A0A5F9C1N1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9986:LOC100346594
gene id: 9986:LOC100346594
uniprot id: G1TXD4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100339169
gene id: 9986:LOC100339169
uniprot id: G1SYQ4
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9986:TLR6
gene id: 9986:TLR6
uniprot id: G1SQ63
uniprot id: M9T577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9986:ASZ1
gene id: 9986:ASZ1
uniprot id: Q09YN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9986:LOC100347395
gene id: 9986:LOC100347395
uniprot id: A0A5F9C7S1
uniprot id: G1SVW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9986:LOC100338644
gene id: 9986:LOC100338644
uniprot id: G1SG20
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9986:TSHB
gene id: 9986:TSHB
uniprot id: B2CZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9986:RHBG
gene id: 9986:RHBG
uniprot id: Q95JD4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cytoplasmic vesicle membrane
messages: Functions as a specific ammonium transporter.
messages: Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.
messages: N-glycosylated.

9986:LOC100349237
gene id: 9986:LOC100349237
uniprot id: G1T978
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100125979
gene id: 9986:LOC100125979
uniprot id: G1TDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9986:LOC100356199
gene id: 9986:LOC100356199
uniprot id: A0A5F9DUB4
uniprot id: G1SGM8
names: Similarity
messages: Belongs to the TAF11 family.

9986:LOC100357425
gene id: 9986:LOC100357425
uniprot id: A0A5F9D5W2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100353716
gene id: 9986:LOC100353716
uniprot id: A0A5F9C4K5
uniprot id: A0A5F9CSA3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100357372
gene id: 9986:LOC100357372
uniprot id: G1SY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350842
gene id: 9986:LOC100350842
uniprot id: G1TDD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9986:LOC100343600
gene id: 9986:LOC100343600
uniprot id: G1TAG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

9986:LOC100347226
gene id: 9986:LOC100347226
uniprot id: G1SZG9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9986:LOC100339303
gene id: 9986:LOC100339303
uniprot id: A0A5F9CMT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100345247
gene id: 9986:LOC100345247
uniprot id: G1TZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9986:IL18RAP
gene id: 9986:IL18RAP
uniprot id: G3EPL2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9986:LOC100009166
gene id: 9986:LOC100009166
uniprot id: P26202
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Binds to bacterial lipopolysaccharides (LPS), potentiates strongly the early antibacterial effects of BPI. Inhibits the late lethal action of BPI.
messages: Large granules of neutrophils.
messages: Secreted

9986:LOC100338968
gene id: 9986:LOC100338968
uniprot id: G1SSL6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100356113
gene id: 9986:LOC100356113
uniprot id: G1SXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9986:LOC100346952
gene id: 9986:LOC100346952
uniprot id: G1SLC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9986:LOC100347672
gene id: 9986:LOC100347672
uniprot id: A0A5F9DJM6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9986:CRP
gene id: 9986:CRP
uniprot id: P02742
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Asp-61, Arg-76, Arg-77, and Glu-81 may be involved in the calcium-dependent binding of phosphorylcholine, a property that may be important for the biological function of this protein.
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
messages: Found in plasma.
messages: Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).
messages: Secreted
messages: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

9986:LOC100338682
gene id: 9986:LOC100338682
uniprot id: G1SCU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:RPS6KB1
gene id: 9986:RPS6KB1
uniprot id: P67998
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activation requires multiple phosphorylation events on serine/threonine residues. Activation appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by PDPK1. The active conformation of the kinase is believed to be stabilized by a mechanism involving three conserved phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase C-terminal domain (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its end). Activated by mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits activating phosphorylation at Thr-412. Activated by PDPK1 (By similarity).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Cytoplasm
messages: Interacts with PPP1R9A/neurabin-1. Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with TRAF4. Interacts with POLDIP3. Interacts (via N-terminus) with IER5.
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism. Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion (By similarity).
messages: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement thr…
messages: The TOS (TOR signaling) motif is essential for activation by mTORC1.
messages: The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop.
messages: synaptosome

9986:LOC103351453
gene id: 9986:LOC103351453
uniprot id: U3KNU4
names: Similarity
messages: Belongs to the SYCE family.

9986:LOC100348062
gene id: 9986:LOC100348062
uniprot id: G1TD27
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100358194
gene id: 9986:LOC100358194
uniprot id: G1SP49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9986:LOC100351476
gene id: 9986:LOC100351476
uniprot id: A0A5F9DA10
uniprot id: G1TCZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9986:PAPSS1
gene id: 9986:PAPSS1
uniprot id: Q6IVV5
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9986:LOC100346634
gene id: 9986:LOC100346634
uniprot id: A0A5F9CY65
uniprot id: A0A5F9DFJ2
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9986:HTR1B
gene id: 9986:HTR1B
uniprot id: P49144
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D (By similarity).
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Palmitoylated.
messages: Phosphorylated.

9986:LOC100357683
gene id: 9986:LOC100357683
uniprot id: G1TUV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9986:LOC100352793
gene id: 9986:LOC100352793
uniprot id: G1T4R5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9986:LOC100350587
gene id: 9986:LOC100350587
uniprot id: G1U3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9986:DYNLL1
gene id: 9986:DYNLL1
uniprot id: P63169
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
messages: Belongs to the dynein light chain family.
messages: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
messages: Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2. Interacts with BCAS1. Interacts with Bassoon/BSN (By similarity). Interacts with HDAC6 (By similarity). Interacts with TPPP (By similarity). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (By similarity). Interacts with FAM83D/CHICA (via C-terminus) (By similarity). Interacts with HMMR, SPAG5/Astrin and KNSTRN/Kinastrin (By similarity). Interacts with TLK2 (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylation at Ser-88 appears to control the dimer-monomer transition.
messages: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
messages: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).
messages: centrosome
messages: cytoskeleton

9986:LOC100339324
gene id: 9986:LOC100339324
uniprot id: G1SHG6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:TNFSF13
gene id: 9986:TNFSF13
uniprot id: A7XIF3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9986:LOC100345337
gene id: 9986:LOC100345337
uniprot id: G1T3J3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9986:LOC100346276
gene id: 9986:LOC100346276
uniprot id: G1TLT8
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9986:LOC100344821
gene id: 9986:LOC100344821
uniprot id: G1SYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:LOC100348617
gene id: 9986:LOC100348617
uniprot id: A0A5F9DGV4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9986:LOC100338505
gene id: 9986:LOC100338505
uniprot id: G1SKU8
names: Similarity
messages: Belongs to the SNF7 family.

9986:LOC108176505
gene id: 9986:LOC108176505
uniprot id: A0A5F9DW69
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9986:LOC100354352
gene id: 9986:LOC100354352
uniprot id: G1TR82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9986:CCKBR
gene id: 9986:CCKBR
uniprot id: G1STT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9986:LOC100347594
gene id: 9986:LOC100347594
uniprot id: G1STK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9986:LOC100349854
gene id: 9986:LOC100349854
uniprot id: G1SN21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9986:LOC100343990
gene id: 9986:LOC100343990
uniprot id: G1SIB1
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9986:BMP2
gene id: 9986:BMP2
uniprot id: O46564
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.
messages: Homodimer; disulfide-linked. Interacts with SOSTDC1 (By similarity). Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2. Interacts with type I receptor BMPR1A. Interacts with type II receptor BMPR2 (By similarity). Interacts with SCUBE3 (By similarity). Interacts with TNFAIP6 (primarily via Link domain); this interaction is inhibited by hyaluronan.
messages: Secreted

9986:ADRA1A
gene id: 9986:ADRA1A
uniprot id: O02824
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in liver, vas deferens, brain, and aorta, but not in heart.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
messages: caveola

9986:LOC100009033
gene id: 9986:LOC100009033
uniprot id: A0A5F9CJK2
uniprot id: G1T851
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC100344047
gene id: 9986:LOC100344047
uniprot id: G1TLM5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9986:NTMT2
gene id: 9986:NTMT2
uniprot id: G1TA44
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9986:LOC100359022
gene id: 9986:LOC100359022
uniprot id: G1TD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9986:LOC100347020
gene id: 9986:LOC100347020
uniprot id: G1SKS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9986:LOC100349255
gene id: 9986:LOC100349255
uniprot id: G1T4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9986:LOC100347570
gene id: 9986:LOC100347570
uniprot id: P02591
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9986:CACNA2D1
gene id: 9986:CACNA2D1
uniprot id: P13806
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel subunit alpha-2/delta family.
messages: Binds gabapentin, an antiepileptic drug.
messages: Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio.
messages: Membrane
messages: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
messages: Skeletal muscle.
messages: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
messages: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.

9986:LOC100350244
gene id: 9986:LOC100350244
uniprot id: G1SYK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:LOC100343092
gene id: 9986:LOC100343092
uniprot id: G1T0T4
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9986:LOC100344600
gene id: 9986:LOC100344600
uniprot id: G1SE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9986:LOC100342948
gene id: 9986:LOC100342948
uniprot id: G1T0V1
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100346403
gene id: 9986:LOC100346403
uniprot id: A0A5F9CPD1
uniprot id: G1TD30
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9986:LOC100342117
gene id: 9986:LOC100342117
uniprot id: A0A5F9D479
uniprot id: A0A5F9DEI5
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9986:LOC100356565
gene id: 9986:LOC100356565
uniprot id: G1SQA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9986:LOC100359118
gene id: 9986:LOC100359118
uniprot id: G1TUM0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100341491
gene id: 9986:LOC100341491
uniprot id: A0A5F9DUR0
uniprot id: G1TS38
names: Similarity
messages: Belongs to the CCDC90 family.

9986:LOC100345251
gene id: 9986:LOC100345251
uniprot id: G1SHF3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9986:LOC100339066
gene id: 9986:LOC100339066
uniprot id: G1TRG8
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9986:LOC100355646
gene id: 9986:LOC100355646
uniprot id: G1SZ66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9986:LOC100353506
gene id: 9986:LOC100353506
uniprot id: A0A5F9DL31
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9986:LOC100346993
gene id: 9986:LOC100346993
uniprot id: G1T1N3
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9986:LOC100358077
gene id: 9986:LOC100358077
uniprot id: A0A5F9CH43
uniprot id: G1SUE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9986:LOC100340199
gene id: 9986:LOC100340199
uniprot id: G1TWL4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9986:LOC100346218
gene id: 9986:LOC100346218
uniprot id: G1SX33
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9986:LOC100339301
gene id: 9986:LOC100339301
uniprot id: A0A5F9C5G4
uniprot id: G1SIB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9986:LOC100344419
gene id: 9986:LOC100344419
uniprot id: G1SGI0
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9986:LOC100347556
gene id: 9986:LOC100347556
uniprot id: G1T7P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9986:LOC100345663
gene id: 9986:LOC100345663
uniprot id: G1T5J7
names: Similarity
messages: Belongs to the yippee family.

9986:LOC100357729
gene id: 9986:LOC100357729
uniprot id: G1SD37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9986:LOC100337723
gene id: 9986:LOC100337723
uniprot id: G1T8R5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9986:LOC100357396
gene id: 9986:LOC100357396
uniprot id: G1U697
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9986:MYOZ1
gene id: 9986:MYOZ1
uniprot id: G1T3K5
uniprot id: Q1AG02
names: Similarity
messages: Belongs to the myozenin family.

9986:HOXA9
gene id: 9986:HOXA9
uniprot id: B7NZT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9986:LOC108177411
gene id: 9986:LOC108177411
uniprot id: G1SYU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9986:LOC100352070
gene id: 9986:LOC100352070
uniprot id: A0A5F9DG62
uniprot id: G1T508
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9986:LOC100344111
gene id: 9986:LOC100344111
uniprot id: G1SD02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9986:LOC100344410
gene id: 9986:LOC100344410
uniprot id: G1TQ90
names: Similarity
messages: Belongs to the histone H3 family.

9986:LOC100341211
gene id: 9986:LOC100341211
uniprot id: G1TG36
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100339056
gene id: 9986:LOC100339056
uniprot id: G1SE68
names: Subcellular Location Annotation
messages: Nucleus

9986:MLLT11
gene id: 9986:MLLT11
uniprot id: E2J6N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9986:LOC100345272
gene id: 9986:LOC100345272
uniprot id: G1T303
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9986:LOC100342183
gene id: 9986:LOC100342183
uniprot id: U3KMG9
names: Similarity
messages: Belongs to the RASGRP family.

9986:LOC100350981
gene id: 9986:LOC100350981
uniprot id: G1SFJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9986:LOC100348081
gene id: 9986:LOC100348081
uniprot id: G1TCR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9986:LOC100337741
gene id: 9986:LOC100337741
uniprot id: A0A5F9CYH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:PLN
gene id: 9986:PLN
uniprot id: P61015
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Heart.
messages: Homopentamer. Interacts with HAX1. Interact with ATP2A2; the inhibition decreases ATP2A2 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with S100A1 in a Ca(2+)-dependent manner.
messages: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis.
messages: Membrane
messages: Mitochondrion membrane
messages: Palmitoylated by ZDHHC16, promoting formation of the homopentamer.
messages: Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity).
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
messages: Sarcoplasmic reticulum membrane

9986:POGLUT3
gene id: 9986:POGLUT3
uniprot id: G1T7L7
names: Similarity
messages: Belongs to the KDELC family.

9986:CORO1B
gene id: 9986:CORO1B
uniprot id: Q9XS70
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2 (By similarity). Binds actin.
messages: Phosphorylated in vivo by PKC in response to cholinergic stimulation. Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location (By similarity).
messages: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
messages: cytoskeleton
messages: stress fiber

9986:LOC100354211
gene id: 9986:LOC100354211
uniprot id: G1STY8
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9986:LOC100357138
gene id: 9986:LOC100357138
uniprot id: G1T3V3
uniprot id: G1TJA4
names: Similarity
messages: Belongs to the RICTOR family.

9986:LOC100352077
gene id: 9986:LOC100352077
uniprot id: G1TC65
names: Similarity
messages: Belongs to the SHQ1 family.

9986:LOC100358799
gene id: 9986:LOC100358799
uniprot id: A0A5F9DS44
names: Subunit
messages: Homodimer.

9986:LOC100345415
gene id: 9986:LOC100345415
uniprot id: G1T3S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9986:LOC100354372
gene id: 9986:LOC100354372
uniprot id: G1SJE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9986:LOC100345611
gene id: 9986:LOC100345611
uniprot id: G1TM06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:NPVF
gene id: 9986:NPVF
uniprot id: A0A5B9BWH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9986:LOC103350666
gene id: 9986:LOC103350666
uniprot id: G1SM38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

9986:ECRG4
gene id: 9986:ECRG4
uniprot id: G1U6W9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9986:COL8A1
gene id: 9986:COL8A1
uniprot id: P14282
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: 4 consecutive G-P-P tripeptides are present at the C-terminus of the triple-helical region. These may provide high thermal stability of this region.
messages: Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrahedron stabilized by central interacting C-terminal NC1 trimers (By similarity).
messages: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin (By similarity).
messages: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
messages: basement membrane

9986:LOC100359287
gene id: 9986:LOC100359287
uniprot id: A0A5F9DAB9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100355119
gene id: 9986:LOC100355119
uniprot id: G1SHK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9986:LOC100337931
gene id: 9986:LOC100337931
uniprot id: G1T2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

9986:LOC100352782
gene id: 9986:LOC100352782
uniprot id: G1TFN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9986:LNPK
gene id: 9986:LNPK
uniprot id: G1SW89
uniprot id: U3KN12
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9986:LOC100357075
gene id: 9986:LOC100357075
uniprot id: A0A5F9CG29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9986:TYRP1
gene id: 9986:TYRP1
uniprot id: H9AYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9986:LOC103348569
gene id: 9986:LOC103348569
uniprot id: G1TG89
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9986:ORYCUNV1R1540
gene id: 9986:ORYCUNV1R1540
uniprot id: A0A5F9DF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC108176709
gene id: 9986:LOC108176709
uniprot id: G1SE76
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9986:PATZ1
gene id: 9986:PATZ1
uniprot id: B7NZM3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC103345646
gene id: 9986:LOC103345646
uniprot id: G1TZU8
names: Similarity
messages: Belongs to the sorting nexin family.

9986:LOC100357847
gene id: 9986:LOC100357847
uniprot id: A0A5F9DGK2
uniprot id: G1STL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9986:LOC100037714
gene id: 9986:LOC100037714
uniprot id: G1SN79
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345044
gene id: 9986:LOC100345044
uniprot id: G1TZ76
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100346125
gene id: 9986:LOC100346125
uniprot id: A0A5F9C826
uniprot id: G1SJD4
uniprot id: G1TLU9
names: Similarity
messages: Belongs to the GAB family.

9986:LOC100355764
gene id: 9986:LOC100355764
uniprot id: G1TDR1
names: Similarity
messages: Belongs to the FAM149 family.

9986:LOC100351135
gene id: 9986:LOC100351135
uniprot id: G1U974
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

9986:LOC100343294
gene id: 9986:LOC100343294
uniprot id: G1T2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9986:LOC100349445
gene id: 9986:LOC100349445
uniprot id: A0A5F9C1V9
uniprot id: A0A5F9DG64
uniprot id: G1SLK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9986:LOC100342070
gene id: 9986:LOC100342070
uniprot id: A0A5F9DEA6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100357395
gene id: 9986:LOC100357395
uniprot id: G1SSV2
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9986:LOC100350560
gene id: 9986:LOC100350560
uniprot id: G1SRI1
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9986:LOC100350743
gene id: 9986:LOC100350743
uniprot id: A0A5F9CI14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9986:LOC100351342
gene id: 9986:LOC100351342
uniprot id: G1T3U9
names: Similarity
messages: Belongs to the cyclin family.

9986:LOC100343930
gene id: 9986:LOC100343930
uniprot id: G1T4P5
names: Similarity
messages: Belongs to the intermediate filament family.

9986:ITGB8
gene id: 9986:ITGB8
uniprot id: P26013
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8. ITGAV:ITGB8 interacts with TGFB1.
messages: Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity).
messages: Placenta, kidney, brain, ovary, uterus and in several transformed cells.

9986:LOC100353077
gene id: 9986:LOC100353077
uniprot id: G1TV70
names: Similarity
messages: Belongs to the cytochrome P450 family.

9986:LOC100347229
gene id: 9986:LOC100347229
uniprot id: G1T1S3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100354441
gene id: 9986:LOC100354441
uniprot id: G1SVT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9986:LOC100358901
gene id: 9986:LOC100358901
uniprot id: A0A5F9DKW5
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9986:LOC100348927
gene id: 9986:LOC100348927
uniprot id: A0A5F9C9Q0
uniprot id: A0A5F9D198
uniprot id: A0A5F9DKG6
names: Subcellular Location Annotation
messages: Z line

9986:LOC100355525
gene id: 9986:LOC100355525
uniprot id: A0A5F9CQ14
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100348236
gene id: 9986:LOC100348236
uniprot id: A0A5F9DJM0
uniprot id: G1SMP5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:LOC100343210
gene id: 9986:LOC100343210
uniprot id: A0A5F9CSM8
names: Similarity
messages: Belongs to the BZW family.

9986:LOC100355851
gene id: 9986:LOC100355851
uniprot id: A0A5F9CLK3
uniprot id: A0A5F9D0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9986:LOC100340600
gene id: 9986:LOC100340600
uniprot id: A0A5F9CLU6
uniprot id: A0A5F9CM72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9986:LOC100358982
gene id: 9986:LOC100358982
uniprot id: G1T192
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9986:LOC100342234
gene id: 9986:LOC100342234
uniprot id: G1SIS9
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9986:LOC100357927
gene id: 9986:LOC100357927
uniprot id: G1T6G5
names: Similarity
messages: Belongs to the histone H3 family.

9986:LOC100340891
gene id: 9986:LOC100340891
uniprot id: G1T6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9986:LOC100341619
gene id: 9986:LOC100341619
uniprot id: G1TT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350470
gene id: 9986:LOC100350470
uniprot id: G1STJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100348427
gene id: 9986:LOC100348427
uniprot id: G1STR3
names: Similarity
messages: Belongs to the BACURD family.

9986:LOC100344169
gene id: 9986:LOC100344169
uniprot id: G1T9D7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100343455
gene id: 9986:LOC100343455
uniprot id: G1TD87
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9986:LOC100354176
gene id: 9986:LOC100354176
uniprot id: G1SWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9986:LOC100346906
gene id: 9986:LOC100346906
uniprot id: G1STM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9986:FMO5
gene id: 9986:FMO5
uniprot id: Q04799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (By similarity). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity).
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Kidney and liver.
messages: Microsome membrane

9986:LOC100356394
gene id: 9986:LOC100356394
uniprot id: G1SXN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9986:LOC100347870
gene id: 9986:LOC100347870
uniprot id: A0A5F9C123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341695
gene id: 9986:LOC100341695
uniprot id: A0A5F9CZ41
uniprot id: A0A5F9DKW1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9986:LOC100337823
gene id: 9986:LOC100337823
uniprot id: G1T2H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9986:LOC100356326
gene id: 9986:LOC100356326
uniprot id: G1T524
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9986:LOC100357163
gene id: 9986:LOC100357163
uniprot id: G1ST18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100346975
gene id: 9986:LOC100346975
uniprot id: G1SVP6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100344835
gene id: 9986:LOC100344835
uniprot id: A0A5F9DSK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100342184
gene id: 9986:LOC100342184
uniprot id: G1SXI1
names: Similarity
messages: Belongs to the TTC27 family.

9986:LOC100353538
gene id: 9986:LOC100353538
uniprot id: G1U8T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343227
gene id: 9986:LOC100343227
uniprot id: A0A5F9CKX6
names: Similarity
messages: Belongs to the MELT/VEPH family.

9986:IL1RN
gene id: 9986:IL1RN
uniprot id: P26890
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9986:LOC100342214
gene id: 9986:LOC100342214
uniprot id: G1T583
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9986:CRYAB
gene id: 9986:CRYAB
uniprot id: P41316
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with ATP6V1A and with MTOR, forming a ternary complex (By similarity).
messages: Lens as well as other tissues.
messages: Lysosome
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
messages: Nucleus
messages: Secreted

9986:LOC100357864
gene id: 9986:LOC100357864
uniprot id: G1TH36
names: Subcellular Location Annotation
messages: focal adhesion

9986:LOC100358504
gene id: 9986:LOC100358504
uniprot id: G1SY29
names: Similarity
messages: Belongs to the TMEM178 family.

9986:LOC100348747
gene id: 9986:LOC100348747
uniprot id: G1SFJ1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100338072
gene id: 9986:LOC100338072
uniprot id: G1T6B6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100338546
gene id: 9986:LOC100338546
uniprot id: G1TPQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:MARCHF4
gene id: 9986:MARCHF4
uniprot id: G1TQM5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100339847
gene id: 9986:LOC100339847
uniprot id: G1SR89
names: Similarity
messages: Belongs to the LanC-like protein family.

9986:CKMT1B
gene id: 9986:CKMT1B
uniprot id: B7NZE9
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9986:LOC100355047
gene id: 9986:LOC100355047
uniprot id: G1SR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100347514
gene id: 9986:LOC100347514
uniprot id: A0A5F9C524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9986:LOC100345520
gene id: 9986:LOC100345520
uniprot id: G1TPP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9986:LOC100355765
gene id: 9986:LOC100355765
uniprot id: G1SL87
names: Subcellular Location Annotation
messages: ruffle membrane

9986:LOC100358780
gene id: 9986:LOC100358780
uniprot id: G1SIG3
names: Subcellular Location Annotation
messages: nucleolus

9986:LOC100338775
gene id: 9986:LOC100338775
uniprot id: A0A5F9C517
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100343505
gene id: 9986:LOC100343505
uniprot id: G1T7Z6
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9986:LOC100347180
gene id: 9986:LOC100347180
uniprot id: G1SER5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9986:LOC100343392
gene id: 9986:LOC100343392
uniprot id: G1SVF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9986:LOC103351994
gene id: 9986:LOC103351994
uniprot id: A0A5F9DVF6
names: Similarity
messages: Belongs to the GPRASP family.

9986:LOC100353677
gene id: 9986:LOC100353677
uniprot id: A0A5F9CTQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9986:LOC100338403
gene id: 9986:LOC100338403
uniprot id: G1TCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9986:LOC100346713
gene id: 9986:LOC100346713
uniprot id: G1SUR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100341339
gene id: 9986:LOC100341339
uniprot id: G1SNI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9986:ART1
gene id: 9986:ART1
uniprot id: Q03515
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.
messages: Has ADP-ribosyltransferase activity toward GLP1R.
messages: Primarily in skeletal and cardiac muscle.
messages: Sarcoplasmic reticulum membrane

9986:LOC100341510
gene id: 9986:LOC100341510
uniprot id: A0A5F9DSJ9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100357966
gene id: 9986:LOC100357966
uniprot id: G1TB95
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100344338
gene id: 9986:LOC100344338
uniprot id: A0A5F9D6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC103348903
gene id: 9986:LOC103348903
uniprot id: G1U3T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9986:GALNT17
gene id: 9986:GALNT17
uniprot id: G1SSD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100345480
gene id: 9986:LOC100345480
uniprot id: G1SNB5
uniprot id: U3KPG8
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9986:GBA1
gene id: 9986:GBA1
uniprot id: G1SD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

9986:LOC100339635
gene id: 9986:LOC100339635
uniprot id: G1SFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9986:LOC100344240
gene id: 9986:LOC100344240
uniprot id: G1U5Z8
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9986:LOC100339708
gene id: 9986:LOC100339708
uniprot id: G1T8A5
names: Similarity
messages: Belongs to the zygin family.

9986:LOC100355145
gene id: 9986:LOC100355145
uniprot id: A0A5F9DR24
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:LOC100358338
gene id: 9986:LOC100358338
uniprot id: G1SDW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9986:ADAM2
gene id: 9986:ADAM2
uniprot id: Q28660
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
messages: Expressed specifically in testis.
messages: Heterodimer with ADAM1/fertilin subunit alpha.
messages: Membrane
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity).
messages: The signal and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.

9986:LOC100343993
gene id: 9986:LOC100343993
uniprot id: G1T2T7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:ORYCUNV1R1524
gene id: 9986:ORYCUNV1R1524
uniprot id: G1TH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355098
gene id: 9986:LOC100355098
uniprot id: G1T6X9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100340493
gene id: 9986:LOC100340493
uniprot id: G1TBU0
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9986:PNLIP
gene id: 9986:PNLIP
uniprot id: G1T7N2
uniprot id: Q02157
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS.
messages: Inhibited by bile salts, is reactivated by (pro)colipase/CLPS.
messages: Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
messages: Secreted

9986:LOC100346821
gene id: 9986:LOC100346821
uniprot id: G1SPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9986:LOC100358871
gene id: 9986:LOC100358871
uniprot id: G1T0C3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9986:LOC100343736
gene id: 9986:LOC100343736
uniprot id: G1SF11
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100358811
gene id: 9986:LOC100358811
uniprot id: G1TJ70
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100337914
gene id: 9986:LOC100337914
uniprot id: G1T4P9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343903
gene id: 9986:LOC100343903
uniprot id: G1TD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100337977
gene id: 9986:LOC100337977
uniprot id: G1U509
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9986:LOC100357665
gene id: 9986:LOC100357665
uniprot id: A0A5F9D132
uniprot id: A0A5F9DKP2
uniprot id: G1STC7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:LOC100343279
gene id: 9986:LOC100343279
uniprot id: G1TS33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355641
gene id: 9986:LOC100355641
uniprot id: A0A5F9CY99
uniprot id: G1SDE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9986:LOC100343557
gene id: 9986:LOC100343557
uniprot id: P80291
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
messages: Monomer.

9986:LOC100349840
gene id: 9986:LOC100349840
uniprot id: G1ST07
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:EIF4E
gene id: 9986:EIF4E
uniprot id: P29338
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Cytoplasm
messages: Nucleus
messages: P-body
messages: Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (By similarity). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity).
messages: Stress granule
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions (By similarity). It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3 (PubMed:6853548). EIF4E is also known to interact with other partners. Interacts with EIF4ENIF1/4E-T; promotes recruitment to P-bodies and import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts mutually exclusive with EIF4A1 or EIF4A2 (By similarity). Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with CLOCK (By similarity). Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with LARP1. Interacts with METTL3. Interacts with RBM24; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex. Interacts with DDX3X; interaction is direct and in an RNA-independent manner; this interaction enhances EIF4E cap-binding ability and is required for the repression of cap-dependent translation and the increase of IRES-mediated translation. DDX3X competes with EIF4G1 for interaction with EIF4E (By similarity). Interacts with BTG4 and CNOT7 (By similarity).

9986:LOC100353845
gene id: 9986:LOC100353845
uniprot id: G1T9S5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:ORYCUNV1R1530
gene id: 9986:ORYCUNV1R1530
uniprot id: A0A5F9DJ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345267
gene id: 9986:LOC100345267
uniprot id: G1T0F8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100341232
gene id: 9986:LOC100341232
uniprot id: G1THC6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100338170
gene id: 9986:LOC100338170
uniprot id: G1T0G5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9986:LOC100356803
gene id: 9986:LOC100356803
uniprot id: G1SZ44
names: Similarity
messages: Belongs to the GroES chaperonin family.

9986:TCP1
gene id: 9986:TCP1
uniprot id: B2ZDY6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9986:LOC100347964
gene id: 9986:LOC100347964
uniprot id: G1SRR0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100348512
gene id: 9986:LOC100348512
uniprot id: G1SMX2
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100354766
gene id: 9986:LOC100354766
uniprot id: A0A5F9CTS3
uniprot id: G1SD84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9986:LOC100353274
gene id: 9986:LOC100353274
uniprot id: G1SW64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9986:LOC100352381
gene id: 9986:LOC100352381
uniprot id: G1T7N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9986:LOC100357708
gene id: 9986:LOC100357708
uniprot id: G1SHR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100341011
gene id: 9986:LOC100341011
uniprot id: A0A5F9DRX2
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9986:LOC100349699
gene id: 9986:LOC100349699
uniprot id: A0A5F9CQ85
names: Subcellular Location Annotation
messages: Nucleus

9986:SNURF
gene id: 9986:SNURF
uniprot id: Q9XS97
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNURF family.
messages: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
messages: Nucleus

9986:LOC100341340
gene id: 9986:LOC100341340
uniprot id: G1SIW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100343182
gene id: 9986:LOC100343182
uniprot id: U3KNG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100353524
gene id: 9986:LOC100353524
uniprot id: G1SIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9986:LOC100353888
gene id: 9986:LOC100353888
uniprot id: G1SMG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100356819
gene id: 9986:LOC100356819
uniprot id: A0A5F9CL18
uniprot id: G1SEF0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9986:LOC100337903
gene id: 9986:LOC100337903
uniprot id: A0A5F9D9J3
uniprot id: G1T941
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9986:LOC100352152
gene id: 9986:LOC100352152
uniprot id: G1SLA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9986:LOC103347893
gene id: 9986:LOC103347893
uniprot id: G1TYQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9986:LOC100355842
gene id: 9986:LOC100355842
uniprot id: G1TYW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:THRSP
gene id: 9986:THRSP
uniprot id: G1SEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100340525
gene id: 9986:LOC100340525
uniprot id: G1U492
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100358374
gene id: 9986:LOC100358374
uniprot id: G1TU40
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346550
gene id: 9986:LOC100346550
uniprot id: G1T706
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

9986:LOC100338382
gene id: 9986:LOC100338382
uniprot id: G1TEQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9986:RYR1
gene id: 9986:RYR1
uniprot id: P11716
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by reversible S-nitrosylation (PubMed:22036948). Repeated very high-level exercise increases S-nitrosylation (By similarity).
messages: Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily.
messages: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:3722165, PubMed:10388749, PubMed:10097181, PubMed:12732639, PubMed:22036948, PubMed:26245150, PubMed:27662087). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
messages: Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843.
messages: Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity (PubMed:27662087). At low concentrations, ryanodine maintains the channel in an open conformation (PubMed:27662087). High ryanodine concentrations inhibit channel activity (PubMed:27662087). Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP (PubMed:12732639, PubMed:22036948, PubMed:26245150, PubMed:27662087). Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (PubMed:12732639).
messages: Coexpression of normal and mutant Thr-4897 RYR1 in a 1:1 ratio produces RYR1 channels with normal halothane and caffeine sensitivities, but maximal levels of Ca(2+) release are reduced by 67%. Binding of [3H]ryanodine indicates that the heterozygous channel is activated by Ca(2+) concentrations 4-fold lower than normal. Single-cell analysis of cotransfected cells shows a significantly increased resting cytoplasmic Ca(2+) level and a significantly reduced luminal Ca(2+) level. These data indicated a leaky channel, possibly caused by a reduction in the Ca(2+) concentration required for channel activation.
messages: Detected in skeletal muscle (at protein level) (PubMed:2725677, PubMed:3722165, PubMed:25470059, PubMed:25517095, PubMed:27573175, PubMed:27468892). Fast- or slow-twitch skeletal muscle.
messages: Homotetramer (PubMed:10097181, PubMed:15908964, PubMed:17027503, PubMed:18621707, PubMed:25470059, PubMed:25517095, PubMed:27662087, PubMed:27573175, PubMed:27468892). Can also form heterotetramers with RYR2 (PubMed:12213830). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1) (By similarity). Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity (PubMed:10601232, PubMed:11562475, PubMed:17027503). Interacts with S100A1 (By similarity). Interacts with FKBP1A; this stabilizes the closed conformation of the channel (PubMed:7669046, PubMed:10603943, PubMed:26245150, PubMed:25517095, PubMed:27468892). Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel (PubMed:10388749). Interacts with CACNB1 (PubMed:21320436). Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity (PubMed:9737879, PubMed:19398037). Interacts with SELENON (PubMed:18713863). Interacts with scorpion calcins (AC P0DPT1; AC P0DM30; AC A0A1L4BJ42; AC P59868; AC P60254; AC B8QG00; AC L0GBR1; AC P60252; AC P60253) (PubMed:27114612).
messages: Membrane
messages: Sarcoplasmic reticulum
messages: Sarcoplasmic reticulum membrane
messages: The N-terminus is blocked.
messages: The calcium release channel activity resides in the C-terminal region while the remaining part of the protein constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum (SR) and the T-tubule (PubMed:2725677, PubMed:25517095, PubMed:27662087, PubMed:27573175, PubMed:27468892). Pore opening is mediated via the cytoplasmic calcium-binding domains that mediate a small rotation of the channel-forming transmembrane regions that then leads to channel opening (PubMed:27468892).

9986:LOC100351667
gene id: 9986:LOC100351667
uniprot id: G1T8R3
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100358180
gene id: 9986:LOC100358180
uniprot id: G1SE24
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9986:LOC103352009
gene id: 9986:LOC103352009
uniprot id: A0A5F9CM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340511
gene id: 9986:LOC100340511
uniprot id: G1TDT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9986:LOC100356590
gene id: 9986:LOC100356590
uniprot id: G1T7T9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355855
gene id: 9986:LOC100355855
uniprot id: A0A5F9DH45
uniprot id: G1SKR5
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100358331
gene id: 9986:LOC100358331
uniprot id: G1TXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9986:LOC100354980
gene id: 9986:LOC100354980
uniprot id: G1TSG1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9986:LOC100351024
gene id: 9986:LOC100351024
uniprot id: G1U8A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9986:LOC100355936
gene id: 9986:LOC100355936
uniprot id: G1T0C9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9986:LOC100344580
gene id: 9986:LOC100344580
uniprot id: G1TYZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9986:LOC100342431
gene id: 9986:LOC100342431
uniprot id: A0A5F9DQH9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100346793
gene id: 9986:LOC100346793
uniprot id: A0A5F9DEI1
names: Similarity
messages: Belongs to the RimK family.

9986:LOC100347895
gene id: 9986:LOC100347895
uniprot id: G1TSY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9986:LOC100101591
gene id: 9986:LOC100101591
uniprot id: G1T0H6
names: Similarity
messages: Belongs to the peptidase C14A family.

9986:LOC100341515
gene id: 9986:LOC100341515
uniprot id: G1TKY2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100355723
gene id: 9986:LOC100355723
uniprot id: G1SQZ8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9986:CLCN5
gene id: 9986:CLCN5
uniprot id: Q9TTU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable).
messages: Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.

9986:LOC100345162
gene id: 9986:LOC100345162
uniprot id: G1SQ50
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9986:LOC100347370
gene id: 9986:LOC100347370
uniprot id: A0A5F9DFD5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100344898
gene id: 9986:LOC100344898
uniprot id: G1TE28
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9986:LOC100349776
gene id: 9986:LOC100349776
uniprot id: G1SQK9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100357863
gene id: 9986:LOC100357863
uniprot id: G1T283
names: Similarity
messages: Belongs to the FAM216 family.

9986:LOC100342539
gene id: 9986:LOC100342539
uniprot id: G1SSY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:KEF51 p11
gene id: 9986:KEF51_p11
uniprot id: A0A3Q8UFL2
uniprot id: O79429
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100343340
gene id: 9986:LOC100343340
uniprot id: G1TN19
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9986:OR51F2
gene id: 9986:OR51F2
uniprot id: B8K147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354123
gene id: 9986:LOC100354123
uniprot id: G1SMB8
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9986:LOC100344295
gene id: 9986:LOC100344295
uniprot id: A0A5F9CWH0
uniprot id: G1SPQ9
names: Subcellular Location Annotation
messages: focal adhesion

9986:FSCN3
gene id: 9986:FSCN3
uniprot id: B6A7Q8
uniprot id: G1SFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9986:ATP1B1
gene id: 9986:ATP1B1
uniprot id: Q9TT37
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Glutathionylated (By similarity). N-glycosylated (By similarity).
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (PubMed:21454534). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1 (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity). Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity).
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).
messages: sarcolemma

9986:SLC25A24
gene id: 9986:SLC25A24
uniprot id: O18757
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity).
messages: Mainly expressed in colon. Also expressed in the small intestine proximal to the ileum. Weakly expressed in kidney but not in the liver.
messages: Mitochondrion inner membrane
messages: Peroxisome
messages: The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (By similarity).

9986:LOC100352084
gene id: 9986:LOC100352084
uniprot id: G1T8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

9986:LOC108177579
gene id: 9986:LOC108177579
uniprot id: G1TFU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:EZR
gene id: 9986:EZR
uniprot id: Q8HZQ5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
messages: Apical cell membrane
messages: Cell projection
messages: Has three main structural domains: an N-terminal FERM domain, a central alpha-helical domain and a C-terminal actin-binding domain.
messages: Interacts with PALS1 (PubMed:15677456). Found in a complex with EZR, PODXL and SLC9A3R2. Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1, SLC9A3R2 and TMEM8B. Interacts (when phosphorylated) with FES/FPS. Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites. Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin. Detected in a complex composed of at least EZR, AHNAK, PPL and PRX. Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition. Interacts with SPN/CD43 cytoplasmic tail, CD44 and ICAM2 (By similarity).
messages: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
messages: Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).
messages: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
messages: The FERM domain is organized in a clover-shaped structure that comprises three subdomains identified as F1 (residues 2-82), F2 (residues 96-198), and F3 (residues 204-296). In the active form, the subdomain F3 adopts two mutually exclusive conformational isomers where a row of four phenylalanine side chains (Phe250, Phe255, Phe267 and Phe269) must point in the same direction. In the autoinhibited form, the F3 subdomain interacts with the C-terminal domain (residues 516-586) and stabilizes the structure, selecting only one possible arrangement of phenylalanine side chains. The FERM domain mediates binding to membrane lipids and signaling molecules.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: The central alpha-helical domain is composed of two alpha helices (residues 326-406 and 417-466) connected by a linker. It protrudes from the FERM domain forming a coiled coil structure where the linker can have either a loop or a helix conformation. The monomer is predicted to form an intra-molecular helix-loop-helix coiled coil structure. Whereas the dimer adopts an elongated dumbbell-shaped configuration where continuous alpha helices from each protomer are organized in a antiparallel coiled coil structure that connect FERM:C-terminal domain swapped complex at each end. The dimer is predicted to link actin filaments parallel to the plasma membrane.
messages: cell cortex
messages: cytoskeleton
messages: microvillus
messages: microvillus membrane
messages: ruffle membrane

9986:CCDC93
gene id: 9986:CCDC93
uniprot id: B7NZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

9986:LOC100348299
gene id: 9986:LOC100348299
uniprot id: G1TFT3
names: Similarity
messages: Belongs to the APC1 family.

9986:ATP5PF
gene id: 9986:ATP5PF
uniprot id: G1U8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9986:LOC100353374
gene id: 9986:LOC100353374
uniprot id: G1TZX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9986:LOC100350479
gene id: 9986:LOC100350479
uniprot id: G1SHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9986:LOC100355027
gene id: 9986:LOC100355027
uniprot id: G1SWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9986:LOC100357080
gene id: 9986:LOC100357080
uniprot id: A0A5F9DF75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9986:MMP13
gene id: 9986:MMP13
uniprot id: O62806
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: N-glycosylated.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity).
messages: Secreted
messages: The C-terminal region binds to collagen.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme (By similarity).
messages: The proenzyme is activated by removal of the propeptide; this cleavage can be effected by other matrix metalloproteinases, such as MMP2, MMP3 and MMP14 and may involve several cleavage steps. Cleavage can also be autocatalytic, after partial maturation by another protease or after treatment with 4-aminophenylmercuric acetate (APMA) (in vitro) (By similarity).
messages: Tyrosine phosphorylated by PKDCC/VLK.
messages: extracellular matrix

9986:LOC100344591
gene id: 9986:LOC100344591
uniprot id: A0A5F9CVK4
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9986:SERPINF2
gene id: 9986:SERPINF2
uniprot id: A0A5F9DFI8
uniprot id: Q45GR2
names: Similarity
messages: Belongs to the serpin family.

9986:MMP2
gene id: 9986:MMP2
uniprot id: P50757
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B (By similarity).
messages: Membrane
messages: Nucleus
messages: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).
messages: Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro (By similarity).
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3) (By similarity). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3 (By similarity).
messages: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).
messages: extracellular matrix

9986:LOC100357160
gene id: 9986:LOC100357160
uniprot id: A0A5F9C3B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9986:LOC100347891
gene id: 9986:LOC100347891
uniprot id: A0A5F9C2P1
uniprot id: A0A5F9DKX0
uniprot id: G1T5Z8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100348681
gene id: 9986:LOC100348681
uniprot id: G1STQ7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350089
gene id: 9986:LOC100350089
uniprot id: A0A5F9DH83
uniprot id: G1U583
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9986:LOC100353390
gene id: 9986:LOC100353390
uniprot id: A0A7R8C371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100345014
gene id: 9986:LOC100345014
uniprot id: G1SCZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9986:FSHB
gene id: 9986:FSHB
uniprot id: Q6IY73
uniprot id: S4VM32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

9986:POU5F1
gene id: 9986:POU5F1
uniprot id: A2ICN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

9986:LOC100352404
gene id: 9986:LOC100352404
uniprot id: G1T6S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9986:SLC22A3
gene id: 9986:SLC22A3
uniprot id: Q5DNW0
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100342557
gene id: 9986:LOC100342557
uniprot id: G1SW58
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9986:LOC100353898
gene id: 9986:LOC100353898
uniprot id: G1TA40
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9986:LOC100339332
gene id: 9986:LOC100339332
uniprot id: G1SGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9986:LOC100340254
gene id: 9986:LOC100340254
uniprot id: G1T6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9986:LOC100338923
gene id: 9986:LOC100338923
uniprot id: A0A5F9CAP0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:MMP9
gene id: 9986:MMP9
uniprot id: P41246
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 3 Ca(2+) ions per subunit.
messages: Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with LCN2. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
messages: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (By similarity). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity).
messages: N- and O-glycosylated.
messages: Osteoclasts.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9986:ATP2A1
gene id: 9986:ATP2A1
uniprot id: P04191
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Endoplasmic reticulum membrane
messages: Inhibited by sarcolipin (SLN) and myoregulin (MRLN) (PubMed:10551848, PubMed:8428955, PubMed:29081402). Inhibited by phospholamban (PLN) (PubMed:10551848, PubMed:8428955, PubMed:29081402, PubMed:23996003). Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (PubMed:10551848, PubMed:8428955, PubMed:29081402, PubMed:23996003). Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium (PubMed:10551848, PubMed:8428955). This inhibition is regulated by the phosphorylation of PLN (PubMed:10551848, PubMed:8428955). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
messages: Interacts with sarcolipin (SLN) (PubMed:29081402, PubMed:23455422, PubMed:23455424). Interacts with phospholamban (PLN) (PubMed:8428955, PubMed:10551848, PubMed:29081402, PubMed:23996003). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts VMP1 (By similarity).
messages: Isoform SERCA1A and isoform SERCA1B are predominantly found in adult and neonatal skeletal muscle respectively.
messages: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:10914677, PubMed:11438520, PubMed:15189864, PubMed:29081402, PubMed:18075584, PubMed:24270570, PubMed:23996003). Contributes to calcium sequestration involved in muscular excitation/contraction.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site on ATP2A1 that is situated between the ATP2A1 transmembrane helices.
messages: Sarcoplasmic reticulum membrane
messages: Skeletal muscle (at protein level) (PubMed:11438520, PubMed:15189864, PubMed:29081402, PubMed:10864315, PubMed:18075584, PubMed:23996003, PubMed:23455422). Skeletal muscle, fast twitch muscle (type II) fibers (PubMed:2936465, PubMed:3029125).

9986:LOC100101571
gene id: 9986:LOC100101571
uniprot id: A0A5F9DEB5
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9986:LOC100359115
gene id: 9986:LOC100359115
uniprot id: G1SMG2
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100351243
gene id: 9986:LOC100351243
uniprot id: A0A5F9CA57
names: Function
messages: GTPase-activating protein for p21-rac.

9986:LOC100354611
gene id: 9986:LOC100354611
uniprot id: A0A5F9CKU7
uniprot id: A0A5F9D4I8
uniprot id: A0A5F9DSU5
uniprot id: G1TMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

9986:LOC100348766
gene id: 9986:LOC100348766
uniprot id: A0A5F9D2Q8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342237
gene id: 9986:LOC100342237
uniprot id: A0A5F9CIX6
uniprot id: G1SQF3
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100338306
gene id: 9986:LOC100338306
uniprot id: G1SQS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9986:OLFR658
gene id: 9986:OLFR658
uniprot id: B8K1B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346810
gene id: 9986:LOC100346810
uniprot id: G1SXE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9986:LOC100357217
gene id: 9986:LOC100357217
uniprot id: G1SIV0
uniprot id: U3KN16
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9986:OR51E2
gene id: 9986:OR51E2
uniprot id: B8K140
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC103350787
gene id: 9986:LOC103350787
uniprot id: G1SMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9986:LOC100340983
gene id: 9986:LOC100340983
uniprot id: A0A5F9D6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100008830
gene id: 9986:LOC100008830
uniprot id: G1SV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9986:LOC100008966
gene id: 9986:LOC100008966
uniprot id: G1T035
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9986:LOC100352924
gene id: 9986:LOC100352924
uniprot id: A0A5F9D1E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9986:LOC100358004
gene id: 9986:LOC100358004
uniprot id: G1TAW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LIPH
gene id: 9986:LIPH
uniprot id: Q9BDJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Expressed in liver and lacrimal gland.
messages: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity). Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity).
messages: Secreted

9986:LOC100338764
gene id: 9986:LOC100338764
uniprot id: A0A5F9DES9
uniprot id: G1TB16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9986:LOC100341335
gene id: 9986:LOC100341335
uniprot id: G1SQW3
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9986:LOC100338006
gene id: 9986:LOC100338006
uniprot id: G1SY70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9986:KEF51 p02
gene id: 9986:KEF51_p02
uniprot id: A0A3Q8UF77
uniprot id: O79438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9986:LOC100328911
gene id: 9986:LOC100328911
uniprot id: Q08862
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Alpha family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Liver.

9986:LOC100352537
gene id: 9986:LOC100352537
uniprot id: G1T298
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100352038
gene id: 9986:LOC100352038
uniprot id: G1T563
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
messages: Nucleus

9986:LOC100339246
gene id: 9986:LOC100339246
uniprot id: G1T494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9986:LOC100352281
gene id: 9986:LOC100352281
uniprot id: W0UV77
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:LOC100338215
gene id: 9986:LOC100338215
uniprot id: A0A5F9CWT4
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9986:LOC100346443
gene id: 9986:LOC100346443
uniprot id: G1TWV2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100353087
gene id: 9986:LOC100353087
uniprot id: G1TJ14
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100351692
gene id: 9986:LOC100351692
uniprot id: G1TFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100347124
gene id: 9986:LOC100347124
uniprot id: G1SSX0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340345
gene id: 9986:LOC100340345
uniprot id: G1SIN5
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9986:LOC100355269
gene id: 9986:LOC100355269
uniprot id: G1SRG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9986:LOC100353429
gene id: 9986:LOC100353429
uniprot id: G1SNQ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9986:OLR140
gene id: 9986:OLR140
uniprot id: B8K182
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341367
gene id: 9986:LOC100341367
uniprot id: G1SEJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9986:LOC100349838
gene id: 9986:LOC100349838
uniprot id: A0A5F9CUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9986:LOC100346105
gene id: 9986:LOC100346105
uniprot id: G1U6I3
names: Subcellular Location Annotation
messages: Synapse

9986:LOC100342027
gene id: 9986:LOC100342027
uniprot id: G1STL2
names: Similarity
messages: Belongs to the GST superfamily.

9986:LOC100346500
gene id: 9986:LOC100346500
uniprot id: G1SZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9986:LOC100339506
gene id: 9986:LOC100339506
uniprot id: G1T537
names: Subcellular Location Annotation
messages: Nucleus

9986:AOX3
gene id: 9986:AOX3
uniprot id: A0A5F9CFN6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9986:LOC100350547
gene id: 9986:LOC100350547
uniprot id: G1TLM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:FMO4
gene id: 9986:FMO4
uniprot id: G1SIC2
uniprot id: P36367
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Kidney and liver.
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

9986:TLCD5
gene id: 9986:TLCD5
uniprot id: G1SNE2
names: Subcellular Location Annotation
messages: Membrane

9986:ORYCUNV1R1629
gene id: 9986:ORYCUNV1R1629
uniprot id: G1TLV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:OLR108
gene id: 9986:OLR108
uniprot id: B8K167
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345352
gene id: 9986:LOC100345352
uniprot id: G1T8A1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9986:LOC100341278
gene id: 9986:LOC100341278
uniprot id: G1SUJ5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100350643
gene id: 9986:LOC100350643
uniprot id: G1T4L8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:HINT1
gene id: 9986:HINT1
uniprot id: P80912
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HINT family.
messages: Cytoplasm
messages: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:11805111, PubMed:15703176). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:15703176). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:20940308). Hydrolyzes Met-AMP, His-AMP, Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:20940308). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (By similarity).
messages: Homodimer (By similarity). Interacts with CDK7 (By similarity). Interacts with RUVBL1 and RUVBL2 and is associated with the LEF1/TCF1-CTNNB1 complex and with a KAT5 histone acetyltransferase complex (By similarity). Identified in a complex with MITF and CTNNB1 (By similarity). Interacts with CDC34 and RBX1, and is part of a SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Interacts with SUMO1, SUMO2 and RGS17 (By similarity). Interacts with the Ten-1 ICD form of TENM1 (By similarity). Interacts with CALM1; interaction increases in the presence of calcium ions (By similarity).
messages: Nucleus
messages: Was originally thought to be a protein kinase C inhibitor and to bind zinc in solution. Both seem to be incorrect.
messages: Widely expressed.

9986:LOC100341610
gene id: 9986:LOC100341610
uniprot id: G1SNK7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346230
gene id: 9986:LOC100346230
uniprot id: G1TGC6
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9986:LOC100357917
gene id: 9986:LOC100357917
uniprot id: G1T0R9
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9986:LOC100343998
gene id: 9986:LOC100343998
uniprot id: G1SQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9986:LGSN
gene id: 9986:LGSN
uniprot id: Q0GA40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Dodecamer. Interacts with BFSP2 and VIM.
messages: May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).

9986:LOC100343573
gene id: 9986:LOC100343573
uniprot id: G1SZC6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355394
gene id: 9986:LOC100355394
uniprot id: G1T744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9986:LOC100348898
gene id: 9986:LOC100348898
uniprot id: G1T7G7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100349437
gene id: 9986:LOC100349437
uniprot id: G1T2K5
names: Similarity
messages: Belongs to the MYBBP1A family.

9986:ABCC9
gene id: 9986:ABCC9
uniprot id: A0A5F9DML2
uniprot id: A0A5F9DT32
uniprot id: G1SUB8
uniprot id: P82451
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Interacts with KCNJ11.
messages: Membrane
messages: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

9986:LOC100356484
gene id: 9986:LOC100356484
uniprot id: A0A5F9CDR2
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9986:LOC100351184
gene id: 9986:LOC100351184
uniprot id: G1T1F0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9986:ORYCUNV1R1638
gene id: 9986:ORYCUNV1R1638
uniprot id: A0A5F9CFJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350827
gene id: 9986:LOC100350827
uniprot id: G1SLT1
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9986:LOC100352955
gene id: 9986:LOC100352955
uniprot id: U3KN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:RLA-DR-ALPHA
gene id: 9986:RLA-DR-ALPHA
uniprot id: Q30847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:SERPINB13
gene id: 9986:SERPINB13
uniprot id: A0A5F9CPM5
uniprot id: B7NZ95
uniprot id: G1SLZ4
names: Similarity
messages: Belongs to the serpin family.

9986:NR2E1
gene id: 9986:NR2E1
uniprot id: B7NZG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100350836
gene id: 9986:LOC100350836
uniprot id: G1U5K3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:FGF7
gene id: 9986:FGF7
uniprot id: G1SRJ5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:ADRA1B
gene id: 9986:ADRA1B
uniprot id: Q9MYI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9986:ATP5MC1
gene id: 9986:ATP5MC1
uniprot id: G1TB58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9986:LOC100338066
gene id: 9986:LOC100338066
uniprot id: A0A5F9DE49
uniprot id: G1SJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

9986:LOC100346878
gene id: 9986:LOC100346878
uniprot id: A0A5F9DQC0
uniprot id: A0A5F9DW54
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:FHIP1A
gene id: 9986:FHIP1A
uniprot id: G1SHZ0
names: Similarity
messages: Belongs to the FHIP family.

9986:LOC100352936
gene id: 9986:LOC100352936
uniprot id: G1SSZ1
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9986:LOC100344574
gene id: 9986:LOC100344574
uniprot id: G1TVY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Interacts with PINK1, ABCE1 and CNOT4.
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

9986:LOC100340901
gene id: 9986:LOC100340901
uniprot id: G1T7P5
names: Similarity
messages: Belongs to the neuronatin family.

9986:LOC100341460
gene id: 9986:LOC100341460
uniprot id: G1SFK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9986:LOC100356723
gene id: 9986:LOC100356723
uniprot id: G1TX03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9986:LOC100349956
gene id: 9986:LOC100349956
uniprot id: G1SPP0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9986:NPC1
gene id: 9986:NPC1
uniprot id: Q9TT75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9986:LOC100357126
gene id: 9986:LOC100357126
uniprot id: G1SUS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9986:LOC100338386
gene id: 9986:LOC100338386
uniprot id: A0A5F9CQH2
uniprot id: A0A5F9D1H0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9986:LOC100346070
gene id: 9986:LOC100346070
uniprot id: A0A5F9CN74
names: Similarity
messages: Belongs to the MSANTD3 family.

9986:LOC100353584
gene id: 9986:LOC100353584
uniprot id: A0A5F9DUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SPEG
gene id: 9986:SPEG
uniprot id: B7NZH2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

9986:LOC100343978
gene id: 9986:LOC100343978
uniprot id: G1T2I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9986:LOC100342835
gene id: 9986:LOC100342835
uniprot id: A0A5F9DKQ4
uniprot id: G1SZY9
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC103350761
gene id: 9986:LOC103350761
uniprot id: A0A5F9DMH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9986:LOC100348010
gene id: 9986:LOC100348010
uniprot id: G1SDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9986:LOC100348977
gene id: 9986:LOC100348977
uniprot id: G1SSU4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9986:LOC100355968
gene id: 9986:LOC100355968
uniprot id: A0A5F9CBN6
uniprot id: G1SY88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9986:LOC100345988
gene id: 9986:LOC100345988
uniprot id: A0A5F9C4H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9986:LOC100352485
gene id: 9986:LOC100352485
uniprot id: A0A5F9D8G4
uniprot id: G1T1Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9986:LOC100339827
gene id: 9986:LOC100339827
uniprot id: A0A5F9DUD6
uniprot id: G1T437
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9986:LOC100348903
gene id: 9986:LOC100348903
uniprot id: G1SZH8
names: Similarity
messages: Belongs to the VPS52 family.

9986:LOC100341166
gene id: 9986:LOC100341166
uniprot id: G1SYU2
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

9986:LOC100357410
gene id: 9986:LOC100357410
uniprot id: G1SQB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100356579
gene id: 9986:LOC100356579
uniprot id: G1TBI2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100341014
gene id: 9986:LOC100341014
uniprot id: G1TGI3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100349681
gene id: 9986:LOC100349681
uniprot id: G1SY64
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100344742
gene id: 9986:LOC100344742
uniprot id: G1SUI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:MINDY4
gene id: 9986:MINDY4
uniprot id: A0A5F9CKC0
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9986:CYP2C4
gene id: 9986:CYP2C4
uniprot id: P11371
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
messages: This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

9986:LOC100343733
gene id: 9986:LOC100343733
uniprot id: G1TYA3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9986:CLNS1A
gene id: 9986:CLNS1A
uniprot id: G1THY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9986:LOC100358146
gene id: 9986:LOC100358146
uniprot id: G1SNJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CYP2C30
gene id: 9986:CYP2C30
uniprot id: Q29510
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9986:LOC100347910
gene id: 9986:LOC100347910
uniprot id: G1SL80
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9986:LOC100339491
gene id: 9986:LOC100339491
uniprot id: G1T4I7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9986:LOC100339537
gene id: 9986:LOC100339537
uniprot id: G1U041
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:PSAT1
gene id: 9986:PSAT1
uniprot id: P10658
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: By progesterone.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Homodimer.

9986:LOC100345620
gene id: 9986:LOC100345620
uniprot id: G1T447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9986:LOC100358697
gene id: 9986:LOC100358697
uniprot id: G1SHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9986:EMP1
gene id: 9986:EMP1
uniprot id: P54850
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane
messages: Most abundant in squamous epithelia.

9986:LOC100354046
gene id: 9986:LOC100354046
uniprot id: G1TEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9986:PRKCA
gene id: 9986:PRKCA
uniprot id: P10102
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42. Negatively regulates myocardial contract…
messages: Cell membrane
messages: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full activation.
messages: Cytoplasm
messages: Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to CAVIN2 in the presence of phosphatidylserine. Interacts with PICK1 (via PDZ domain). Interacts with TRIM41. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and RACK1. Interacts with PARD3 (By similarity). Interacts with SOCS2 (By similarity).
messages: Mitochondrion membrane
messages: Nucleus

9986:LOC100343808
gene id: 9986:LOC100343808
uniprot id: A0A5F9DIM4
uniprot id: G1TRS2
names: Similarity
messages: Belongs to the PrpD family.

9986:LOC100342326
gene id: 9986:LOC100342326
uniprot id: G1SRQ4
names: Similarity
messages: Belongs to the FAM161 family.

9986:LOC100349858
gene id: 9986:LOC100349858
uniprot id: G1SJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:PIERCE2
gene id: 9986:PIERCE2
uniprot id: A0A5F9DDL5
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9986:IL1B
gene id: 9986:IL1B
uniprot id: P14628
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9986:PRORP
gene id: 9986:PRORP
uniprot id: G1TS30
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9986:LOC100342383
gene id: 9986:LOC100342383
uniprot id: A0A5F9C326
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9986:LOC100342186
gene id: 9986:LOC100342186
uniprot id: G1SXX0
names: Similarity
messages: Belongs to the sorting nexin family.

9986:LOC100009328
gene id: 9986:LOC100009328
uniprot id: A0A5F9CPT1
uniprot id: A0A5F9DS61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9986:LOC100357662
gene id: 9986:LOC100357662
uniprot id: G1SQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9986:CAVIN2
gene id: 9986:CAVIN2
uniprot id: G1TEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9986:NR1H4
gene id: 9986:NR1H4
uniprot id: Q8SPF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:LOC100344818
gene id: 9986:LOC100344818
uniprot id: A0A5F9D4Y0
uniprot id: G1SGV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9986:LOC100338224
gene id: 9986:LOC100338224
uniprot id: A0A5F9CJ14
uniprot id: A0A5F9CWB2
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9986:LOC100340567
gene id: 9986:LOC100340567
uniprot id: A0A5F9CJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9986:LOC100358003
gene id: 9986:LOC100358003
uniprot id: G1TSU6
uniprot id: U3KMM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9986:LOC100347475
gene id: 9986:LOC100347475
uniprot id: G1SMA7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100353966
gene id: 9986:LOC100353966
uniprot id: G1SUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9986:LOC103348889
gene id: 9986:LOC103348889
uniprot id: A0A5F9CY41
names: Similarity
messages: Belongs to the peptidase S28 family.

9986:KCNMA1
gene id: 9986:KCNMA1
uniprot id: Q9BG98
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).
messages: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).
messages: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9986:OLFR605
gene id: 9986:OLFR605
uniprot id: B8K188
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:ATP5F1B
gene id: 9986:ATP5F1B
uniprot id: G1SQA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9986:LOC100353440
gene id: 9986:LOC100353440
uniprot id: G1SCY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9986:LOC100346296
gene id: 9986:LOC100346296
uniprot id: G1T7Z1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100348754
gene id: 9986:LOC100348754
uniprot id: G1SV86
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:AR
gene id: 9986:AR
uniprot id: G1TTV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9986:LOC100339168
gene id: 9986:LOC100339168
uniprot id: G1T4U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9986:LOC100343626
gene id: 9986:LOC100343626
uniprot id: A0A5F9D1N4
uniprot id: G1TE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9986:LOC103350073
gene id: 9986:LOC103350073
uniprot id: G1SSN8
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9986:LOC100350259
gene id: 9986:LOC100350259
uniprot id: G1SH94
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC108177327
gene id: 9986:LOC108177327
uniprot id: A0A5F9CB26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353655
gene id: 9986:LOC100353655
uniprot id: G1T8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9986:LOC100008863
gene id: 9986:LOC100008863
uniprot id: A0A5F9C5M5
names: Similarity
messages: Belongs to the FBPase class 1 family.

9986:LOC100341156
gene id: 9986:LOC100341156
uniprot id: G1SSK7
names: Similarity
messages: Belongs to the GPATCH11 family.

9986:LOC100351684
gene id: 9986:LOC100351684
uniprot id: G1T3K1
names: Similarity
messages: Belongs to the DeSI family.

9986:LOC100338187
gene id: 9986:LOC100338187
uniprot id: G1T2S0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100347664
gene id: 9986:LOC100347664
uniprot id: A0A5F9CLH1
uniprot id: G1T1N5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342021
gene id: 9986:LOC100342021
uniprot id: G1SPQ8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9986:LOC100341119
gene id: 9986:LOC100341119
uniprot id: A0A5F9DIV2
uniprot id: A0A5F9DK33
uniprot id: G1TG78
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9986:LOC100351010
gene id: 9986:LOC100351010
uniprot id: G1SMQ4
names: Similarity
messages: Belongs to the costars family.

9986:LOC100347070
gene id: 9986:LOC100347070
uniprot id: A0A5F9CVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9986:LOC100344476
gene id: 9986:LOC100344476
uniprot id: G1SZ78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9986:LOC100344816
gene id: 9986:LOC100344816
uniprot id: G1U7T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9986:LOC100347472
gene id: 9986:LOC100347472
uniprot id: G1SJC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100347596
gene id: 9986:LOC100347596
uniprot id: G1T478
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100343248
gene id: 9986:LOC100343248
uniprot id: G1T6U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9986:LOC100350771
gene id: 9986:LOC100350771
uniprot id: G1SNY0
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9986:LOC100346388
gene id: 9986:LOC100346388
uniprot id: G1U7D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356730
gene id: 9986:LOC100356730
uniprot id: G1SCN4
names: Similarity
messages: Belongs to the NXPE family.

9986:LOC100353801
gene id: 9986:LOC100353801
uniprot id: G1SD33
names: Similarity
messages: Belongs to the MT-A70-like family.

9986:LOC100359294
gene id: 9986:LOC100359294
uniprot id: G1TSC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9986:LOC100356007
gene id: 9986:LOC100356007
uniprot id: A0A5F9DGC8
names: Similarity
messages: Belongs to the sorting nexin family.

9986:LOC100337814
gene id: 9986:LOC100337814
uniprot id: G1TAI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9986:LOC100351882
gene id: 9986:LOC100351882
uniprot id: G1SDK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353006
gene id: 9986:LOC100353006
uniprot id: A0A5F9C5F7
uniprot id: A0A5F9D1M9
uniprot id: A0A5F9DUX2
uniprot id: G1TET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9986:LOC100346782
gene id: 9986:LOC100346782
uniprot id: A0A5F9C4S7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9986:HBG1
gene id: 9986:HBG1
uniprot id: B8K176
uniprot id: P02103
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemoglobin epsilon chain is a beta-type chain found in early embryos.
messages: Red blood cells.

9986:LOC100359155
gene id: 9986:LOC100359155
uniprot id: G1U3S0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100354276
gene id: 9986:LOC100354276
uniprot id: G1TZP0
names: Similarity
messages: Belongs to the 14-3-3 family.

9986:LOC100348223
gene id: 9986:LOC100348223
uniprot id: G1SRZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9986:LOC100348578
gene id: 9986:LOC100348578
uniprot id: G1TP83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100351626
gene id: 9986:LOC100351626
uniprot id: G1T5W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9986:LOC100340407
gene id: 9986:LOC100340407
uniprot id: G1TVM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100337926
gene id: 9986:LOC100337926
uniprot id: G1SIE3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:SHBG
gene id: 9986:SHBG
uniprot id: P15196
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity).
messages: Homodimer.
messages: Secreted

9986:SLC4A10
gene id: 9986:SLC4A10
uniprot id: A0A0K0Q026
uniprot id: A0A0K0Q153
uniprot id: G1SUS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100354523
gene id: 9986:LOC100354523
uniprot id: G1T3V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9986:LOC100350489
gene id: 9986:LOC100350489
uniprot id: G1SZ22
uniprot id: G1U3H3
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9986:LOC100351150
gene id: 9986:LOC100351150
uniprot id: G1SWE7
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9986:LOC100345105
gene id: 9986:LOC100345105
uniprot id: G1SMV5
names: Similarity
messages: Belongs to the hexokinase family.

9986:ATP5F1C
gene id: 9986:ATP5F1C
uniprot id: G1SM77
uniprot id: U3KMU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9986:LOC100348422
gene id: 9986:LOC100348422
uniprot id: G1U344
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9986:LOC100341412
gene id: 9986:LOC100341412
uniprot id: G1SQG5
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9986:LOC100354966
gene id: 9986:LOC100354966
uniprot id: G1SS70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9986:LOC100351559
gene id: 9986:LOC100351559
uniprot id: A0A5F9CFA8
uniprot id: A0A5F9D991
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9986:LOC100340331
gene id: 9986:LOC100340331
uniprot id: G1U124
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9986:LOC100337689
gene id: 9986:LOC100337689
uniprot id: A0A5F9CNS1
uniprot id: G1SQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9986:LOC100341869
gene id: 9986:LOC100341869
uniprot id: G1TBL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9986:LOC100338693
gene id: 9986:LOC100338693
uniprot id: A0A5F9DHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9986:LOC100339063
gene id: 9986:LOC100339063
uniprot id: G1T275
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9986:LIPG
gene id: 9986:LIPG
uniprot id: D5FGX9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:FKBP1A
gene id: 9986:FKBP1A
uniprot id: P62943
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Detected in fast twitch skeletal muscle (at protein level).
messages: Inhibited by both FK506 and rapamycin.
messages: Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts directly with RYR2 and RYR3 (By similarity). Interacts directly with RYR1 (PubMed:1374404, PubMed:10603943, PubMed:25517095, PubMed:27468892). Interacts with GLMN; rapamycin and FK506 abolish the interaction with GLMN in a dose dependent manner (By similarity).
messages: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: cytosol

9986:LOC100355669
gene id: 9986:LOC100355669
uniprot id: A0A7R8GV21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100353372
gene id: 9986:LOC100353372
uniprot id: G1T9F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9986:KEF51 p06
gene id: 9986:KEF51_p06
uniprot id: A0A3Q8UFC3
uniprot id: O79434
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9986:LOC100343591
gene id: 9986:LOC100343591
uniprot id: G1SZG5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350997
gene id: 9986:LOC100350997
uniprot id: G1U2G1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100340294
gene id: 9986:LOC100340294
uniprot id: G1SZC0
names: Subcellular Location Annotation
messages: Nucleus

9986:CCT2
gene id: 9986:CCT2
uniprot id: B6V9S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9986:NR3C1
gene id: 9986:NR3C1
uniprot id: A0A5F9DMK9
uniprot id: P59667
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
messages: Cytoplasm
messages: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C (PubMed:9195923). Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (PubMed:9195923). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Directly interacts with UNC45A (By similarity). Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor (By similarity). Binds STAT5A and STAT5B homodimers and heterodimers (By similarity). Interacts with NRIP1, POU2F1, POU2F2 and TRIM28 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6 (By similarity). Interaction with BAG1 inhibits transactivation (By similarity). Interacts with HEXIM1 and TGFB1I1 (By similarity). Interacts with NCOA1 (By similarity). Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion (By similarity). Interacts with CIART (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with GRIP1 (By similarity). Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE) (By similarity). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation (By similarity). Interacts with GSK3B (By similarity). Interacts with FNIP1 and FNIP2 (By s…
messages: Increased proteasome-mediated degradation in response to glucocorticoids.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-399-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Phosphorylation at Ser-211 increases transcriptional activity. Phosphorylation at Ser-203, Ser-226 and Ser-399 decreases signaling capacity. Phosphorylation at Ser-399 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
messages: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
messages: Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity. Sumoylation at Lys-698 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-698 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner.
messages: Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
messages: centrosome
messages: spindle

9986:LOC100345082
gene id: 9986:LOC100345082
uniprot id: G1TDU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9986:LOC100351125
gene id: 9986:LOC100351125
uniprot id: G1U4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340002
gene id: 9986:LOC100340002
uniprot id: A0A5F9CHQ1
uniprot id: G1T3K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9986:GHSR
gene id: 9986:GHSR
uniprot id: A5A4K9
uniprot id: C0LUT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9986:LOC100349905
gene id: 9986:LOC100349905
uniprot id: G1SX73
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9986:LOC100338343
gene id: 9986:LOC100338343
uniprot id: G1SV82
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9986:OR52E2
gene id: 9986:OR52E2
uniprot id: B8K160
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355136
gene id: 9986:LOC100355136
uniprot id: G1U520
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345440
gene id: 9986:LOC100345440
uniprot id: A0A5F9DC27
uniprot id: G1SXM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9986:LOC100345431
gene id: 9986:LOC100345431
uniprot id: G1SSA4
uniprot id: U3KN00
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100345883
gene id: 9986:LOC100345883
uniprot id: G1TJF6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:GJB1
gene id: 9986:GJB1
uniprot id: G1TMB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:LOC100345500
gene id: 9986:LOC100345500
uniprot id: G1T2B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100009068
gene id: 9986:LOC100009068
uniprot id: G1SDD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

9986:LOC100344510
gene id: 9986:LOC100344510
uniprot id: G1TN22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9986:LOC100347896
gene id: 9986:LOC100347896
uniprot id: G1SUE3
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9986:LOC100340217
gene id: 9986:LOC100340217
uniprot id: U3KP17
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9986:LOC100349029
gene id: 9986:LOC100349029
uniprot id: G1SLY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9986:LOC100346199
gene id: 9986:LOC100346199
uniprot id: G1SFU6
names: Similarity
messages: Belongs to the LIX1 family.

9986:GABARAP
gene id: 9986:GABARAP
uniprot id: Q8MK68
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG8 family.
messages: Cytoplasmic vesicle
messages: Endomembrane system
messages: Golgi apparatus membrane
messages: Interacts with GPHN and NSF (By similarity). Interacts with ATG3, ATG7 and ATG13. Interacts with alpha-tubulin (By similarity). Interacts with beta-tubulin (By similarity). Interacts with GABRG2. Interacts with RB1CC1. Interacts with ULK1. Interacts with CALR. Interacts with DDX47. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D5 (By similarity). Interacts with TBC1D25 (By similarity). Directly interacts with SQSTM1. Interacts with MAPK15. Interacts with TECPR2. Interacts with PCM1. Interacts with TRIM5 and TRIM21. Interacts with MEFV (By similarity). Interacts with KIF21B (By similarity). Interacts with WDFY3; this interaction is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies. Interacts with FLCN; interaction regulates autophagy (By similarity). Interacts with UBA5 (By similarity). Interacts with KBTBD6 and KBTBD7; the interaction is direct and required for the ubiquitination of TIAM1 (By similarity). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (By similarity).
messages: The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAP-I. The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAP-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. ATG4 proteins also mediate the delipidation of PE-conjugated forms. In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy. ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (By similarity).
messages: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis.
messages: autophagosome
messages: cytoskeleton

9986:LOC100349212
gene id: 9986:LOC100349212
uniprot id: G1T9S4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9986:LOC100349570
gene id: 9986:LOC100349570
uniprot id: G1SMV6
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9986:LOC100356435
gene id: 9986:LOC100356435
uniprot id: G1T211
names: Similarity
messages: Belongs to the FAM91 family.

9986:LOC100354049
gene id: 9986:LOC100354049
uniprot id: G1SP95
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100339423
gene id: 9986:LOC100339423
uniprot id: G1TBE0
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100347582
gene id: 9986:LOC100347582
uniprot id: G1TFY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9986:ALDH1A1
gene id: 9986:ALDH1A1
uniprot id: Q75NJ2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9986:LOC100351683
gene id: 9986:LOC100351683
uniprot id: G1SCE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9986:LOC100303760
gene id: 9986:LOC100303760
uniprot id: G1SYW9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:LOC100342646
gene id: 9986:LOC100342646
uniprot id: A0A5F9CHL9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9986:LOC108177184
gene id: 9986:LOC108177184
uniprot id: G1SE76
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9986:CYP2J1
gene id: 9986:CYP2J1
uniprot id: P52786
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the N-demethylation of benzphetamine to formaldehyde.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Small intestine.

9986:LOC100357154
gene id: 9986:LOC100357154
uniprot id: G1SYK9
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9986:SFTPB
gene id: 9986:SFTPB
uniprot id: P15285
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; disulfide-linked.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
messages: surface film

9986:LOC100354064
gene id: 9986:LOC100354064
uniprot id: G1TW10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9986:LOC100341681
gene id: 9986:LOC100341681
uniprot id: A0A5F9CYS9
uniprot id: A0A5F9DGW5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100358456
gene id: 9986:LOC100358456
uniprot id: G1T2K6
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:LOC100353542
gene id: 9986:LOC100353542
uniprot id: G1SW77
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100347172
gene id: 9986:LOC100347172
uniprot id: G1SG49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345910
gene id: 9986:LOC100345910
uniprot id: G1TVA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339424
gene id: 9986:LOC100339424
uniprot id: G1SV04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100345859
gene id: 9986:LOC100345859
uniprot id: G1TUB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9986:ORYCUNV1R1605
gene id: 9986:ORYCUNV1R1605
uniprot id: A0A5F9D2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342439
gene id: 9986:LOC100342439
uniprot id: G1SVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9986:LOC100348780
gene id: 9986:LOC100348780
uniprot id: A0A5F9C4L4
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9986:ACSL6
gene id: 9986:ACSL6
uniprot id: B7NZK5
uniprot id: G1U500
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9986:LOC100345744
gene id: 9986:LOC100345744
uniprot id: G1SH63
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9986:PHB1
gene id: 9986:PHB1
uniprot id: G1SSJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9986:LOC100354013
gene id: 9986:LOC100354013
uniprot id: G1SWA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9986:LOC100353265
gene id: 9986:LOC100353265
uniprot id: A0A5F9DM32
uniprot id: G1SU80
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100352094
gene id: 9986:LOC100352094
uniprot id: A0A5F9CYY7
names: Subcellular Location Annotation
messages: Mitochondrion

9986:LOC100345789
gene id: 9986:LOC100345789
uniprot id: G1SD75
names: Similarity
messages: Belongs to the WFIKKN family.

9986:PODXL
gene id: 9986:PODXL
uniprot id: Q28645
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity).
messages: Glomerular epithelium cell (podocyte) and endothelial cells.
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Found in a complex with EZR, PODXL and SLC9A3R2. Associates with the actin cytoskeleton through complex formation with EZR and SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); interaction is not detected in glomerular epithelium cells, take place early in the secretory pathway and is necessary for its apical membrane sorting. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells. Interacts with EZR (By similarity).
messages: N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9986:LOC100338708
gene id: 9986:LOC100338708
uniprot id: G1T3H4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9986:LOC100353697
gene id: 9986:LOC100353697
uniprot id: G1STB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9986:LOC100345670
gene id: 9986:LOC100345670
uniprot id: A0A5F9DRR4
uniprot id: G1SDL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9986:LOC100338112
gene id: 9986:LOC100338112
uniprot id: G1TK17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9986:LOC100341622
gene id: 9986:LOC100341622
uniprot id: G1SK69
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9986:LOC100353248
gene id: 9986:LOC100353248
uniprot id: G1SS73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

9986:LOC100340515
gene id: 9986:LOC100340515
uniprot id: G1SDS7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100351198
gene id: 9986:LOC100351198
uniprot id: G1TFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9986:CYP2C5
gene id: 9986:CYP2C5
uniprot id: P00179
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
messages: This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

9986:LOC100339626
gene id: 9986:LOC100339626
uniprot id: G1SE03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9986:LOC100350431
gene id: 9986:LOC100350431
uniprot id: G1SYV6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:SLC4A9
gene id: 9986:SLC4A9
uniprot id: Q9GKY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Highly expressed in kidney. Expressed in certain types of cells in the kidney cortex.
messages: Probable apical anion exchanger of the beta-intercalated cells of kidney. May participate in HCO3(-) secretion.

9986:LOC100358123
gene id: 9986:LOC100358123
uniprot id: G1T286
uniprot id: U3KN73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9986:SCTR
gene id: 9986:SCTR
uniprot id: O46502
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Phosphorylated on Ser and Thr residues at the cytoplasmic C-terminus by G protein-coupled receptor kinases (GRKs).
messages: Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).

9986:LOC100344472
gene id: 9986:LOC100344472
uniprot id: G1U971
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9986:LOC103351917
gene id: 9986:LOC103351917
uniprot id: G1T452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9986:LOC100356627
gene id: 9986:LOC100356627
uniprot id: G1SRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:PTHLH
gene id: 9986:PTHLH
uniprot id: G1T697
uniprot id: Q9GLC7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9986:LOC100354160
gene id: 9986:LOC100354160
uniprot id: G1TUP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:UGT2C1
gene id: 9986:UGT2C1
uniprot id: G1U225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9986:LOC100343147
gene id: 9986:LOC100343147
uniprot id: G1TS21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358771
gene id: 9986:LOC100358771
uniprot id: A0A5F9CBX9
uniprot id: A0A5F9CMX0
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100349085
gene id: 9986:LOC100349085
uniprot id: G1T0F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

9986:LOC100341186
gene id: 9986:LOC100341186
uniprot id: A0A5F9CJ46
uniprot id: A0A5F9D2S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9986:LOC100347753
gene id: 9986:LOC100347753
uniprot id: A0A5F9CJC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9986:LOC100349683
gene id: 9986:LOC100349683
uniprot id: G1TEM7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9986:PLP1
gene id: 9986:PLP1
uniprot id: P47789
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Defects in PLP1 are the cause of paralytic tremor (pt); a sex-linked mutation in rabbit that affects myelination of the CNS.
messages: Myelin membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

9986:KCNMB1
gene id: 9986:KCNMB1
uniprot id: O46372
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).

9986:LOC100348840
gene id: 9986:LOC100348840
uniprot id: G1T317
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

9986:LOC100351133
gene id: 9986:LOC100351133
uniprot id: G1TB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9986:LOC100342483
gene id: 9986:LOC100342483
uniprot id: A0A5F9CV67
uniprot id: G1T949
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100355732
gene id: 9986:LOC100355732
uniprot id: G1TNY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9986:LOC100347647
gene id: 9986:LOC100347647
uniprot id: G1TDN8
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100352313
gene id: 9986:LOC100352313
uniprot id: A0A5F9CRV2
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9986:LOC100346052
gene id: 9986:LOC100346052
uniprot id: A0A5F9C3F3
uniprot id: A0A5F9CYW5
uniprot id: G1TQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9986:KHDC4
gene id: 9986:KHDC4
uniprot id: G1SZ95
names: Similarity
messages: Belongs to the KHDC4 family.

9986:LOC100009434
gene id: 9986:LOC100009434
uniprot id: G1SJX1
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9986:LOC100346948
gene id: 9986:LOC100346948
uniprot id: G1SFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9986:LOC100354253
gene id: 9986:LOC100354253
uniprot id: G1SW35
names: Similarity
messages: Belongs to the RAPsyn family.

9986:LOC100357596
gene id: 9986:LOC100357596
uniprot id: G1TUE0
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9986:LOC100356986
gene id: 9986:LOC100356986
uniprot id: G1TX91
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9986:LOC100338723
gene id: 9986:LOC100338723
uniprot id: G1TIP9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100348897
gene id: 9986:LOC100348897
uniprot id: G1U3C5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:SI
gene id: 9986:SI
uniprot id: P07768
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the glycosyl hydrolase 31 family.
messages: N- and O-glycosylated.
messages: Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.
messages: Sulfated.
messages: The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
messages: The resulting sucrase and isomaltase subunits stay associated with one another in a complex by non-covalent linkages.
messages: There is a high degree of homology between the isomaltase and sucrase portions (41% of amino acid identity) indicating that this protein is evolved by partial gene duplication.

9986:LOC100347732
gene id: 9986:LOC100347732
uniprot id: G1T0I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9986:LOC100358097
gene id: 9986:LOC100358097
uniprot id: G1SK57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100357814
gene id: 9986:LOC100357814
uniprot id: G1SQH5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343976
gene id: 9986:LOC100343976
uniprot id: G1SVZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9986:LOC100349561
gene id: 9986:LOC100349561
uniprot id: G1U1X1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.
messages: Membrane
messages: cytoskeleton

9986:LOC100343886
gene id: 9986:LOC100343886
uniprot id: G1TEH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9986:LOC100350241
gene id: 9986:LOC100350241
uniprot id: G1U425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9986:KCNB1
gene id: 9986:KCNB1
uniprot id: Q9MZ19
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival.
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Cell membrane
messages: Homotetramer or heterotetramer with KCNB2. Heterotetramer with non-conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1. Channel activity is regulated by association with ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3. Self-associates (via N-terminus and C-terminus); self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. Interacts (via C-terminus) with STX1A (via C-terminus); this decreases the rate of channel activation and increases the rate of channel inactivation in pancreatic beta cells, induces also neuronal apoptosis in response to oxidative injury as well as pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons. Interacts (via N-terminus) with SNAP25; this decreases the rate of channel inactivation in pancreatic beta cells and also increases interaction during neuronal apoptosis in a N-methyl-D-aspartate receptor (NMDAR)-dependent manner. Interacts (via N-terminus and C-terminus) with VAMP2 (via N-terminus); stimulates channel inactivation rate. Interacts with CREB1; this promotes channel acetylation in response to stimulation by incretin hormones. Interacts (via N-terminus and C-terminus) with MYL12B. Interacts (via N-terminus) with PIAS3; this increases the number of functional channels at the cell surface. Interacts with SUMO1. Interacts (via phosphorylated form) with PTPRE; this reduces phosphorylation and channel activity in heterologous cells.
messages: Inhibited by 12.7 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S.calceata. Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G.spatulata. Modestly sensitive to millimolar levels of tetraethylammonium (TEA). Modestly sensitive to millimolar levels of 4-aminopyridine (4-AP). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX).
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Phosphorylated. Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons. Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities. Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE. CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity. Phosphorylated on Tyr-128 by Src and on Ser-805 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program. Phosphorylated on Ser-520, Ser-607, Ser-656 and Ser-805 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation. The Ser-607 phosphorylation state differs between KCNB1-containing clusters on the proximal and distal portions of the axon initial segment (AIS). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons. Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-dependent gating properties. Dephosphorylation by phosphatase PTPRE confers neuroprotection by its inhibitory influence on the neuronal apoptotic potassium current surge in a Zn(2+)-dependent manner. Dephosphorylated at Ser-607 by protein phosphatase PPP1CA. Hypoxia-, seizure- or glutamate-induced neuronal activity promote calcium/calcineurin-dependent dep…
messages: Postsynaptic cell membrane
messages: Sumoylated on Lys-474, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity. Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells. Desumoylated by SENP1.
messages: Synapse
messages: The N-terminal and C-terminal cytoplasmic regions mediate homooligomerization; self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. The N-terminal cytoplasmic region is important for interaction with other channel-forming alpha subunits and with ancillary beta subunits. The C-terminus is necessary and sufficient for the restricted localization to, and clustering within, both in soma and proximal portions of dendrite of neurons and in lateral membrane of non-neuronal polarized cells. The C-terminus is both necessary and sufficient as a mediator of cholinergic and calcium-stimulated modulation of channel cell membrane clustering localization and activity in hippocampal neurons.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Also plays a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assig…
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

9986:LOC100144342
gene id: 9986:LOC100144342
uniprot id: G1TLR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9986:LOC100346664
gene id: 9986:LOC100346664
uniprot id: G1U5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353435
gene id: 9986:LOC100353435
uniprot id: G1T122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9986:LOC100352270
gene id: 9986:LOC100352270
uniprot id: G1T5U4
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9986:NPY4R
gene id: 9986:NPY4R
uniprot id: B6VRS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100345271
gene id: 9986:LOC100345271
uniprot id: G1SZU2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9986:LOC100008709
gene id: 9986:LOC100008709
uniprot id: G1TC79
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340021
gene id: 9986:LOC100340021
uniprot id: G1T9S6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9986:LOC100354063
gene id: 9986:LOC100354063
uniprot id: G1SIZ2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9986:LOC100341111
gene id: 9986:LOC100341111
uniprot id: U3KMI1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9986:LOC100343889
gene id: 9986:LOC100343889
uniprot id: G1T3J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9986:MTO1
gene id: 9986:MTO1
uniprot id: B7NZC2
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9986:LOC100350246
gene id: 9986:LOC100350246
uniprot id: G1SGJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9986:LOC100350531
gene id: 9986:LOC100350531
uniprot id: G1SN70
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9986:LOC100348815
gene id: 9986:LOC100348815
uniprot id: G1TB00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC108175387
gene id: 9986:LOC108175387
uniprot id: A0A5F9DEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9986:LOC100341721
gene id: 9986:LOC100341721
uniprot id: A0A5F9CN09
uniprot id: G1SYN8
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9986:LOC100342792
gene id: 9986:LOC100342792
uniprot id: G1SRU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9986:LOC100356280
gene id: 9986:LOC100356280
uniprot id: A0A5F9CLZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357839
gene id: 9986:LOC100357839
uniprot id: A0A5F9CW85
names: Similarity
messages: Belongs to the PIAS family.

9986:LOC100347476
gene id: 9986:LOC100347476
uniprot id: A0A5F9DUU9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9986:LOC100358015
gene id: 9986:LOC100358015
uniprot id: A0A5F9C3S5
uniprot id: A0A5F9DHM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345920
gene id: 9986:LOC100345920
uniprot id: A0A5F9D405
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9986:LOC100349117
gene id: 9986:LOC100349117
uniprot id: G1U7H1
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9986:LOC100346044
gene id: 9986:LOC100346044
uniprot id: G1TRP1
names: Subcellular Location Annotation
messages: Membrane

9986:CDK14
gene id: 9986:CDK14
uniprot id: B6A7Q3
uniprot id: G1SWT4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a complex with LRP6, CCNY and CAPRIN2 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.
messages: Nucleus
messages: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.
messages: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).

9986:LOC100338263
gene id: 9986:LOC100338263
uniprot id: A0A5F9CP35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

9986:LOC100356489
gene id: 9986:LOC100356489
uniprot id: G1SIP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

9986:LOC100348291
gene id: 9986:LOC100348291
uniprot id: G1SRA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9986:LOC100338365
gene id: 9986:LOC100338365
uniprot id: A0A5F9CV41
uniprot id: G1TLW8
names: Similarity
messages: Belongs to the Izumo family.

9986:LOC100339777
gene id: 9986:LOC100339777
uniprot id: A0A5F9D2J5
uniprot id: A0A5F9D3B1
uniprot id: G1TNW4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100348324
gene id: 9986:LOC100348324
uniprot id: G1TJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358854
gene id: 9986:LOC100358854
uniprot id: G1SKC5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100354329
gene id: 9986:LOC100354329
uniprot id: G1TC30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345167
gene id: 9986:LOC100345167
uniprot id: A0A5F9CD69
uniprot id: A0A5F9CHG3
uniprot id: A0A5F9DFR2
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100352575
gene id: 9986:LOC100352575
uniprot id: G1SQR7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9986:LOC100338853
gene id: 9986:LOC100338853
uniprot id: G1T2S7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9986:LOC100356346
gene id: 9986:LOC100356346
uniprot id: G1U6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343560
gene id: 9986:LOC100343560
uniprot id: G1SIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9986:PACC1
gene id: 9986:PACC1
uniprot id: A0A5F9C3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9986:LOC100358406
gene id: 9986:LOC100358406
uniprot id: G1TKM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:GUCY1B1
gene id: 9986:GUCY1B1
uniprot id: G1SG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9986:LOC100339229
gene id: 9986:LOC100339229
uniprot id: A0A5F9CBQ4
uniprot id: A0A5F9DNP6
uniprot id: G1SNC0
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100352925
gene id: 9986:LOC100352925
uniprot id: G1T2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9986:TRPC5
gene id: 9986:TRPC5
uniprot id: O62852
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
messages: Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.
messages: Cell membrane
messages: Expressed in brain.
messages: Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts with SLC9A3R1/NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts (via C-terminus) with CABP1 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity).
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).

9986:ZNF687
gene id: 9986:ZNF687
uniprot id: B7NZD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9986:APOA1
gene id: 9986:APOA1
uniprot id: P09809
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Glycosylated.
messages: Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).
messages: Major protein of plasma HDL, also found in chylomicrons.
messages: Palmitoylated.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted

9986:LOC100354854
gene id: 9986:LOC100354854
uniprot id: G1T0D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9986:LOC100347420
gene id: 9986:LOC100347420
uniprot id: G1T9E5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100346766
gene id: 9986:LOC100346766
uniprot id: A0A5F9C3B1
uniprot id: G1U913
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9986:LOC100354849
gene id: 9986:LOC100354849
uniprot id: A0A5F9DBU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9986:ASIP
gene id: 9986:ASIP
uniprot id: B0B577
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100355648
gene id: 9986:LOC100355648
uniprot id: G1TEJ7
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100341245
gene id: 9986:LOC100341245
uniprot id: G1SYH9
names: Similarity
messages: Belongs to the dynein heavy chain family.

9986:LOC103350560
gene id: 9986:LOC103350560
uniprot id: A0A5F9DCH3
uniprot id: A0A5F9DNH2
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100355150
gene id: 9986:LOC100355150
uniprot id: G1T1L6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100340063
gene id: 9986:LOC100340063
uniprot id: G1TDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9986:LOC100354955
gene id: 9986:LOC100354955
uniprot id: G1TT06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9986:LOC100340829
gene id: 9986:LOC100340829
uniprot id: G1T5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9986:LOC100350284
gene id: 9986:LOC100350284
uniprot id: G1SLL3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100357460
gene id: 9986:LOC100357460
uniprot id: G1SFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CXCR2
gene id: 9986:CXCR2
uniprot id: P35344
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed preferentially in neutrophils.
messages: Interacts with IL8. Interacts with GNAI2.
messages: Phosphorylated upon ligand binding; which is required for desensitization.
messages: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

9986:PALS2
gene id: 9986:PALS2
uniprot id: A0A5F9D4R9
names: Similarity
messages: Belongs to the MAGUK family.

9986:WNT5A
gene id: 9986:WNT5A
uniprot id: Q27Q52
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Homooligomer; disulfide-linked, leading to inactivation (in vitro). Interacts with PORCN. Interacts with WLS (By similarity). Interacts with glypican GCP3 (By similarity). Interacts with PKD1 (via extracellular domain) (By similarity). Interacts with TMEM67 (By similarity).
messages: Glycosylation is necessary for secretion but not for activity.
messages: In cartilage and cultured chondrocytes, induced by interleukin IL1B.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur (PubMed:16754689). Inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (By similarity). Inhibits type II collagen expression in chondrocytes (PubMed:16754689).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.
messages: Secreted
messages: extracellular matrix

9986:LOC100357564
gene id: 9986:LOC100357564
uniprot id: G1SM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9986:LOC100351089
gene id: 9986:LOC100351089
uniprot id: G1ST65
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:LOC100338593
gene id: 9986:LOC100338593
uniprot id: G1TJN4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100350063
gene id: 9986:LOC100350063
uniprot id: G1SCT2
names: Similarity
messages: Belongs to the yippee family.

9986:LOC100340248
gene id: 9986:LOC100340248
uniprot id: A0A5F9DG33
uniprot id: G1SIX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:LOC100338312
gene id: 9986:LOC100338312
uniprot id: G1TYP2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9986:LOC100344537
gene id: 9986:LOC100344537
uniprot id: G1U0M2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100339253
gene id: 9986:LOC100339253
uniprot id: A0A5F9CIR2
uniprot id: G1SZ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9986:LOC100356373
gene id: 9986:LOC100356373
uniprot id: G1TKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9986:LOC100358099
gene id: 9986:LOC100358099
uniprot id: A0A5F9C6A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9986:LOC100356607
gene id: 9986:LOC100356607
uniprot id: G1U498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC108175363
gene id: 9986:LOC108175363
uniprot id: G1T6B8
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9986:LOC100356979
gene id: 9986:LOC100356979
uniprot id: A0A5F9CUR5
uniprot id: G1SW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9986:LOC100337691
gene id: 9986:LOC100337691
uniprot id: G1U472
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9986:LOC100340906
gene id: 9986:LOC100340906
uniprot id: G1SF44
names: Similarity
messages: Belongs to the HSBP1 family.

9986:LOC100343541
gene id: 9986:LOC100343541
uniprot id: A0A5F9DHW3
uniprot id: G1SPQ0
names: Subcellular Location Annotation
messages: Z line

9986:LOC100352945
gene id: 9986:LOC100352945
uniprot id: G1T726
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9986:LOC100339058
gene id: 9986:LOC100339058
uniprot id: G1U2I4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355572
gene id: 9986:LOC100355572
uniprot id: G1TGF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
messages: Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.
messages: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation.

9986:LOC100009356
gene id: 9986:LOC100009356
uniprot id: A0A5F9DMA3
uniprot id: G1TAW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:ALOX15
gene id: 9986:ALOX15
uniprot id: P12530
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: According to the authors the mRNA described in PubMed:9600854 may be encoded by a gene different from ALOX15.
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Cell membrane
messages: Detected in reticulocytes (at protein level).
messages: Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.
messages: Lipid droplet
messages: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:9600854, PubMed:9414270, PubMed:15123652, PubMed:17493578, PubMed:18311922). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:9600854, PubMed:9414270, PubMed:15123652, PubMed:17493578). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (PubMed:15123652). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the gener…
messages: The PLAT domain can bind calcium ions; this promotes association with membranes.
messages: cytosol

9986:LOC100348776
gene id: 9986:LOC100348776
uniprot id: G1SE13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9986:MYH13
gene id: 9986:MYH13
uniprot id: Q9GJP9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9986:LOC100340413
gene id: 9986:LOC100340413
uniprot id: G1TMX4
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9986:LOC100338462
gene id: 9986:LOC100338462
uniprot id: G1TR26
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9986:LOC100355022
gene id: 9986:LOC100355022
uniprot id: A0A5F9CNV6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9986:LOC100357566
gene id: 9986:LOC100357566
uniprot id: G1TU46
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346191
gene id: 9986:LOC100346191
uniprot id: G1SZR4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9986:LOC100355816
gene id: 9986:LOC100355816
uniprot id: G1T720
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9986:LOC100359315
gene id: 9986:LOC100359315
uniprot id: G1SGG6
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

9986:ACO1
gene id: 9986:ACO1
uniprot id: G1TAN9
uniprot id: Q01059
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:17185597). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:17185597).
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9986:LOC100354893
gene id: 9986:LOC100354893
uniprot id: G1SVX0
names: Similarity
messages: Belongs to the phosducin family.

9986:HP
gene id: 9986:HP
uniprot id: P19007
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
messages: Belongs to the peptidase S1 family.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted
messages: Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3 (By similarity).
messages: The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface.

9986:LOC108178108
gene id: 9986:LOC108178108
uniprot id: G1SYU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9986:LOC100356310
gene id: 9986:LOC100356310
uniprot id: A0A5F9DQC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9986:LOC100341264
gene id: 9986:LOC100341264
uniprot id: G1SUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9986:LOC100341642
gene id: 9986:LOC100341642
uniprot id: G1T928
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100354350
gene id: 9986:LOC100354350
uniprot id: G1SK76
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350723
gene id: 9986:LOC100350723
uniprot id: A0A5F9CJS5
uniprot id: G1STI0
names: Similarity
messages: Belongs to the stathmin family.

9986:LOC100346082
gene id: 9986:LOC100346082
uniprot id: G1TJU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:UGT2B13
gene id: 9986:UGT2B13
uniprot id: P36512
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed primarily in adult rabbits.
messages: Microsome membrane
messages: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.

9986:LOC100351316
gene id: 9986:LOC100351316
uniprot id: G1SXH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC100359318
gene id: 9986:LOC100359318
uniprot id: G1SCW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9986:LOC100350171
gene id: 9986:LOC100350171
uniprot id: G1SND0
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9986:LOC100341303
gene id: 9986:LOC100341303
uniprot id: G1SDH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9986:GCH1
gene id: 9986:GCH1
uniprot id: G1SIY3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9986:LOC100356222
gene id: 9986:LOC100356222
uniprot id: A0A5F9C6Y8
uniprot id: A0A5F9CLA8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9986:LOC100344303
gene id: 9986:LOC100344303
uniprot id: A0A5F9DE28
uniprot id: G1T7E2
names: Similarity
messages: Belongs to the FAM13 family.

9986:LOC103349691
gene id: 9986:LOC103349691
uniprot id: G1TBM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9986:LOC100352386
gene id: 9986:LOC100352386
uniprot id: G1SGS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9986:LOC100353090
gene id: 9986:LOC100353090
uniprot id: G1U287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC100339654
gene id: 9986:LOC100339654
uniprot id: G1T7M3
names: Similarity
messages: Belongs to the TIP41 family.

9986:LOC100357755
gene id: 9986:LOC100357755
uniprot id: G1SZY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350202
gene id: 9986:LOC100350202
uniprot id: A0A5F9CI45
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100355368
gene id: 9986:LOC100355368
uniprot id: G1U816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9986:LOC100357399
gene id: 9986:LOC100357399
uniprot id: A0A5F9DU32
uniprot id: G1SD42
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100352387
gene id: 9986:LOC100352387
uniprot id: G1T6C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344160
gene id: 9986:LOC100344160
uniprot id: G1SW06
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9986:GC
gene id: 9986:GC
uniprot id: P53789
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3.
messages: Belongs to the ALB/AFP/VDB family.
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9986:LOC100338204
gene id: 9986:LOC100338204
uniprot id: A0A5F9D5V4
uniprot id: G1TP65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100354379
gene id: 9986:LOC100354379
uniprot id: G1T6J7
names: Similarity
messages: Belongs to the MTFP1 family.

9986:LOC100350049
gene id: 9986:LOC100350049
uniprot id: A0A5F9CEL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:TLR2
gene id: 9986:TLR2
uniprot id: Q8MIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane
messages: Membrane raft
messages: phagosome membrane

9986:LOC100343479
gene id: 9986:LOC100343479
uniprot id: A0A5F9D1S8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9986:LOC100350105
gene id: 9986:LOC100350105
uniprot id: G1SLZ0
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9986:LOC100352081
gene id: 9986:LOC100352081
uniprot id: A0A5F9C671
uniprot id: G1SJE4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9986:LOC100348566
gene id: 9986:LOC100348566
uniprot id: G1U1B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9986:LOC100348149
gene id: 9986:LOC100348149
uniprot id: G1SSW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9986:LOC100345736
gene id: 9986:LOC100345736
uniprot id: G1TAN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9986:LOC100359232
gene id: 9986:LOC100359232
uniprot id: G1TU55
names: Subcellular Location Annotation
messages: Cytoplasm

9986:TLCD4
gene id: 9986:TLCD4
uniprot id: G1T6Z7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100357941
gene id: 9986:LOC100357941
uniprot id: U3KM54
names: Similarity
messages: Belongs to the HTATSF1 family.

9986:LOC100349531
gene id: 9986:LOC100349531
uniprot id: G1SLJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9986:LOC100349316
gene id: 9986:LOC100349316
uniprot id: G1TDI0
names: Similarity
messages: Belongs to the peptidase M24 family.

9986:LOC100338174
gene id: 9986:LOC100338174
uniprot id: G1T9A6
names: Similarity
messages: Belongs to the DPCD family.

9986:LOC100353953
gene id: 9986:LOC100353953
uniprot id: G1SMQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9986:LOC100356984
gene id: 9986:LOC100356984
uniprot id: G1STB8
names: Similarity
messages: Belongs to the GDAP2 family.

9986:LOC100345250
gene id: 9986:LOC100345250
uniprot id: G1T758
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9986:LOC108178086
gene id: 9986:LOC108178086
uniprot id: A0A5F9C635
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

9986:LOC100356658
gene id: 9986:LOC100356658
uniprot id: A0A5F9DNK0
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100341466
gene id: 9986:LOC100341466
uniprot id: G1TSW5
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9986:GPRASP3
gene id: 9986:GPRASP3
uniprot id: G1T4M3
names: Similarity
messages: Belongs to the GPRASP family.

9986:DCN
gene id: 9986:DCN
uniprot id: Q28888
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
messages: May affect the rate of fibrils formation.
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9986:LOC100345676
gene id: 9986:LOC100345676
uniprot id: G1SQ46
names: Similarity
messages: Belongs to the Rho GDI family.

9986:LOC100344555
gene id: 9986:LOC100344555
uniprot id: G1TDD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9986:LOC100357338
gene id: 9986:LOC100357338
uniprot id: G1SYX6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100359206
gene id: 9986:LOC100359206
uniprot id: G1U4K9
names: Similarity
messages: Belongs to the actin family.

9986:LOC100349334
gene id: 9986:LOC100349334
uniprot id: G1U0N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100349051
gene id: 9986:LOC100349051
uniprot id: A0A5F9DJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339655
gene id: 9986:LOC100339655
uniprot id: G1SGQ1
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9986:CYP8B1
gene id: 9986:CYP8B1
uniprot id: O02766
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:1400444, PubMed:8943286). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (PubMed:1400444, PubMed:8943286).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Liver (at protein level).
messages: Microsome membrane
messages: Up-regulated upon treatment with streptozotocin.

9986:LOC100355374
gene id: 9986:LOC100355374
uniprot id: G1SI97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9986:LOC100344381
gene id: 9986:LOC100344381
uniprot id: G1SSS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC100341097
gene id: 9986:LOC100341097
uniprot id: A0A5F9D6G1
uniprot id: G1TE15
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100340431
gene id: 9986:LOC100340431
uniprot id: G1T332
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9986:LOC100345522
gene id: 9986:LOC100345522
uniprot id: G1TLE9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100342485
gene id: 9986:LOC100342485
uniprot id: A0A5F9CM09
uniprot id: A0A5F9DMA8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9986:LOC100353616
gene id: 9986:LOC100353616
uniprot id: G1T0X2
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9986:LOC100338799
gene id: 9986:LOC100338799
uniprot id: A0A5F9CEY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339994
gene id: 9986:LOC100339994
uniprot id: G1T398
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9986:LOC100355928
gene id: 9986:LOC100355928
uniprot id: G1T2H3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9986:FGFR2
gene id: 9986:FGFR2
uniprot id: A0A5F9CR83
uniprot id: A0A5F9D4M5
uniprot id: G1SSB0
uniprot id: Q9TTZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100348479
gene id: 9986:LOC100348479
uniprot id: G1T463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9986:LOC100341917
gene id: 9986:LOC100341917
uniprot id: A0A5F9DVS8
names: Similarity
messages: Belongs to the folate receptor family.

9986:LOC100354075
gene id: 9986:LOC100354075
uniprot id: G1SQN5
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9986:LOC100349863
gene id: 9986:LOC100349863
uniprot id: A0A5F9CEX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9986:LOC100339819
gene id: 9986:LOC100339819
uniprot id: G1TN21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

9986:LOC100339079
gene id: 9986:LOC100339079
uniprot id: A0A5F9CK14
uniprot id: A0A5F9D7D7
uniprot id: G1SSB2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100345937
gene id: 9986:LOC100345937
uniprot id: A0A5F9DKP9
uniprot id: G1SKW3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9986:LOC100343882
gene id: 9986:LOC100343882
uniprot id: G1SF12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9986:LOC100341609
gene id: 9986:LOC100341609
uniprot id: G1SUV0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100357500
gene id: 9986:LOC100357500
uniprot id: P56201
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.

9986:LOC100352345
gene id: 9986:LOC100352345
uniprot id: G1SJL6
names: Similarity
messages: Belongs to the CD36 family.

9986:LOC100356403
gene id: 9986:LOC100356403
uniprot id: G1TM90
names: Subcellular Location Annotation
messages: Membrane

9986:RBP4
gene id: 9986:RBP4
uniprot id: P06912
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted

9986:LOC100354098
gene id: 9986:LOC100354098
uniprot id: G1TXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9986:PDE4DIPP2
gene id: 9986:PDE4DIPP2
uniprot id: A0A5F9C9K8
names: Subcellular Location Annotation
messages: centrosome

9986:LOC100348245
gene id: 9986:LOC100348245
uniprot id: U3KNV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9986:LOC100337836
gene id: 9986:LOC100337836
uniprot id: G1SDM3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100341259
gene id: 9986:LOC100341259
uniprot id: A0A5F9C8K4
uniprot id: A0A5F9DJ31
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100354363
gene id: 9986:LOC100354363
uniprot id: G1T9W4
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9986:LOC100341546
gene id: 9986:LOC100341546
uniprot id: A0A5F9CB64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

9986:TMED10
gene id: 9986:TMED10
uniprot id: Q28735
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (By similarity). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:9990005, PubMed:9813083). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (By similarity). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:9990005, PubMed:9813083, PubMed:18182008). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (By similarity). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (PubMed:9813083). On Golgi membranes, acts as primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus. Involved in the exocytic trafficking of G protein-coupl…
messages: Cell membrane
messages: Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization. Interaction of TMED10 with TMED2 is both necessary and sufficient for transport of the couple to the cis-Golgi network, and TMED3 and/or TMED9 contribute to facilitating the process.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Melanosome
messages: Predominantly dimeric and to a lesser extent monomeric in the ER (PubMed:18182008). Monomer and dimer in ERGIC and cis-Golgi network. Forms homooligomer (via GOLD domain); the assembly is promoted by direct binding with leaderless cargos and may form a protein channel that facilitates cargo entry into the ERGIC. Forms heterooligomeric complexes with other members of the p24 family such as TMED2, TMED7 and TMED9 (By similarity). Interacts (via GOLD domain) with TMED2 (via GOLD domain); the complex is required for export of TMED10 from the ER to the cis-Golgi network; the complex is proposed to be involved in cis-Golgi network dynamics and / or biogenesis. Associates with the COPI vesicle coat subunits (coatomer) (PubMed:9990005, PubMed:9813083, PubMed:18182008). Tetramerization of the cytoplasmic domain at the Golgi membrane in vitro; the complex is proposed to interact with COPI coatomer and induce budding of the vesicles (PubMed:18182008). Interacts with COPG1; the interaction involves TMED10 homodimer. Interacts with ARF1 (GDP-bound); the interaction probably involves a TMED10 oligomer. Interacts with SEC23A, SEC24B, SEC24C and SEC24D components of the coat protein complex II/COPII, indicative of an association of TMED10 with the COPII vesicle coat. Interacts with CD59. Interacts with MPPE1/PGAP5; the complex might recruit and sort GPI-anchored proteins to the ER-exit site, or the interaction might lead to recycling of PGAP5 between the ER and the Golgi. Interacts with F2LR1/PAR2 (By similarity). Interacts with KDELR2/ERD2; the interaction is disrupted by KDELR2 ligand (PubMed:9813083) (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10. Associates with the presenilin-dependent gamma-secretase complex. Interacts with STX17; the interaction is direct. Interacts with IL-1; the interaction is direct. Interacts with RAB21 (active GTP-bound form); the interaction is indirect and regulates TMED10 abundance and localization at the Golgi (By s…
messages: The GOLD domain is required for proper p24 heterooligomeric complex formation and efficient transport of GPI-anchored proteins.
messages: The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention by the cytoplasmic domain.
messages: cis-Golgi network membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9986:C9
gene id: 9986:C9
uniprot id: P48747
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
messages: Secreted
messages: Target cell membrane
messages: The structure of the human polymeric form indicates the existence of an additional disulfide bond compared to the mouse monomeric form.
messages: Thrombin cleaves factor C9 to produce C9a and C9b.

9986:ACTA2
gene id: 9986:ACTA2
uniprot id: P62740
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9986:LOC100342638
gene id: 9986:LOC100342638
uniprot id: A0A5F9CU93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9986:LOC100346046
gene id: 9986:LOC100346046
uniprot id: G1SFA6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9986:EIF4ENIF1
gene id: 9986:EIF4ENIF1
uniprot id: B7NZM5
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100340730
gene id: 9986:LOC100340730
uniprot id: G1U3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9986:SLC5A6
gene id: 9986:SLC5A6
uniprot id: Q9XT77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Interacts with PDZD11.
messages: Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate (By similarity). Required for biotin and pantothenate uptake in the instestine (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier (By similarity). May also be involved in the sodium-dependent transport of iodide ions (By similarity).

9986:LOC100353596
gene id: 9986:LOC100353596
uniprot id: G1SHQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9986:LOC100357637
gene id: 9986:LOC100357637
uniprot id: G1SYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9986:LOC100339843
gene id: 9986:LOC100339843
uniprot id: G1SZF9
names: Similarity
messages: Belongs to the peptidase M14 family.

9986:SLC7A8
gene id: 9986:SLC7A8
uniprot id: Q9N1Q4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cytoplasm
messages: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
messages: Mainly expressed in kidney and small intestine.
messages: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
messages: The transport of glutamine and serine was inhibited by glutamine, leucine, alanine, serine, cysteine, phenylalanine, tryptophan threonine and by 2-aminobicyclo-(2,2,1)heptane-2-carboxylic acid (BCH) (a specific inhibitor of system L transport).

9986:LOC100346534
gene id: 9986:LOC100346534
uniprot id: G1T618
names: Similarity
messages: Belongs to the TGF-beta family.

9986:KCNE4
gene id: 9986:KCNE4
uniprot id: A1KZZ9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9986:LOC100358455
gene id: 9986:LOC100358455
uniprot id: A0A5F9DVS0
uniprot id: G1TD52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9986:LOC100353722
gene id: 9986:LOC100353722
uniprot id: G1SMR7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9986:LOC100349597
gene id: 9986:LOC100349597
uniprot id: G1SF19
names: Similarity
messages: Belongs to the TEX28 family.

9986:LOC100341544
gene id: 9986:LOC100341544
uniprot id: A0A5F9CKV6
uniprot id: G1TER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100356526
gene id: 9986:LOC100356526
uniprot id: A0A5F9CE46
names: Similarity
messages: Belongs to the rad9 family.

9986:LOC100356227
gene id: 9986:LOC100356227
uniprot id: G1SIP0
names: Subcellular Location Annotation
messages: Nucleus

9986:ORYCUNV1R1547
gene id: 9986:ORYCUNV1R1547
uniprot id: G1TRG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347077
gene id: 9986:LOC100347077
uniprot id: G1TUZ1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342209
gene id: 9986:LOC100342209
uniprot id: G1SWE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9986:LOC100354369
gene id: 9986:LOC100354369
uniprot id: A0A5F9CF07
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9986:LOC100348930
gene id: 9986:LOC100348930
uniprot id: G1STQ5
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9986:LOC100355621
gene id: 9986:LOC100355621
uniprot id: G1TEA8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9986:LOC100354374
gene id: 9986:LOC100354374
uniprot id: G1TDI6
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9986:LOC103350478
gene id: 9986:LOC103350478
uniprot id: G1SS87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9986:LOC100340930
gene id: 9986:LOC100340930
uniprot id: G1TAW0
names: Similarity
messages: Belongs to the EAF family.

9986:KEF51 p01
gene id: 9986:KEF51_p01
uniprot id: A0A3Q8UFJ6
uniprot id: P34863
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9986:LOC100339140
gene id: 9986:LOC100339140
uniprot id: G1TGN1
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9986:LOC100341358
gene id: 9986:LOC100341358
uniprot id: G1SVQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:LOC100346711
gene id: 9986:LOC100346711
uniprot id: G1TWC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9986:LOC100354630
gene id: 9986:LOC100354630
uniprot id: G1SVA3
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9986:LOC100339317
gene id: 9986:LOC100339317
uniprot id: G1TU99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357544
gene id: 9986:LOC100357544
uniprot id: G1U344
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9986:LOC100349473
gene id: 9986:LOC100349473
uniprot id: G1SIW1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9986:LOC100358576
gene id: 9986:LOC100358576
uniprot id: G1SGK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9986:LOC100350233
gene id: 9986:LOC100350233
uniprot id: G1TCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9986:LOC100339563
gene id: 9986:LOC100339563
uniprot id: G1T9T1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100347968
gene id: 9986:LOC100347968
uniprot id: A0A5F9DKL0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9986:LOC100339282
gene id: 9986:LOC100339282
uniprot id: G1SI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100344255
gene id: 9986:LOC100344255
uniprot id: G1SV79
names: Similarity
messages: Belongs to the TOM1 family.

9986:LOC103350067
gene id: 9986:LOC103350067
uniprot id: G1TKV4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100342307
gene id: 9986:LOC100342307
uniprot id: G1T3R9
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100009512
gene id: 9986:LOC100009512
uniprot id: Q29513
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in liver.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.
messages: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate (PubMed:4692843, PubMed:8281755). Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine (By similarity).
messages: Cytoplasm
messages: Homotetramer.
messages: Inhibited by 5-methyltetrahydrofolate monoglutamate and by 5-methyltetrahydrofolate pentaglutamate, inhibition is much more effective by the pentaglutamate form than by the monoglutamate form. Two molecules of 5-methyltetrahydrofolate are bound per tetramer. The binding sites are localized between subunits. Inhibitor binding may preclude movements of the polypeptide chain that are necessary for enzyme activity.

9986:LOC100350526
gene id: 9986:LOC100350526
uniprot id: A0A5F9DST8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9986:LOC100358299
gene id: 9986:LOC100358299
uniprot id: G1SIT9
names: Similarity
messages: Belongs to the 14-3-3 family.

9986:LOC100340058
gene id: 9986:LOC100340058
uniprot id: A0A5F9CZT7
uniprot id: G1T586
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100353137
gene id: 9986:LOC100353137
uniprot id: G1SMG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100347820
gene id: 9986:LOC100347820
uniprot id: G1TG15
names: Similarity
messages: Belongs to the FAM210 family.

9986:LOC100347377
gene id: 9986:LOC100347377
uniprot id: G1U7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356566
gene id: 9986:LOC100356566
uniprot id: G1SFR6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100352790
gene id: 9986:LOC100352790
uniprot id: G1U7P9
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9986:LOC100358071
gene id: 9986:LOC100358071
uniprot id: G1SRY1
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9986:LOC100351839
gene id: 9986:LOC100351839
uniprot id: G1U6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:APOD
gene id: 9986:APOD
uniprot id: P37153
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Most heavily expressed in adrenal gland, lung, brain, testis and spleen.
messages: Secreted

9986:LOC100349244
gene id: 9986:LOC100349244
uniprot id: G1SZ47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9986:NQO2
gene id: 9986:NQO2
uniprot id: G1TBR1
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9986:LOC100354411
gene id: 9986:LOC100354411
uniprot id: G1T3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100337981
gene id: 9986:LOC100337981
uniprot id: A0A5F9CUM6
uniprot id: G1SKT0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9986:LOC100359289
gene id: 9986:LOC100359289
uniprot id: A0A5F9DNF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100348741
gene id: 9986:LOC100348741
uniprot id: G1TFW8
names: Similarity
messages: Belongs to the transferrin family.

9986:LOC100342443
gene id: 9986:LOC100342443
uniprot id: A0A5F9C4I2
uniprot id: A0A5F9CFH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9986:FOLR1
gene id: 9986:FOLR1
uniprot id: G1SCR2
names: Similarity
messages: Belongs to the folate receptor family.

9986:LOC100357650
gene id: 9986:LOC100357650
uniprot id: G1SMV8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343241
gene id: 9986:LOC100343241
uniprot id: A0A5F9CE00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: cytoskeleton

9986:LOC100353585
gene id: 9986:LOC100353585
uniprot id: G1U1E8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100348721
gene id: 9986:LOC100348721
uniprot id: G1T987
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100342064
gene id: 9986:LOC100342064
uniprot id: A0A5F9DR43
uniprot id: G1TV94
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100357418
gene id: 9986:LOC100357418
uniprot id: A0A5F9DGK0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340192
gene id: 9986:LOC100340192
uniprot id: G1SWW7
names: Similarity
messages: Belongs to the splicing factor SR family.

9986:LOC100354434
gene id: 9986:LOC100354434
uniprot id: G1T4V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plakin or cytolinker family.
messages: cytoskeleton

9986:LOC100341516
gene id: 9986:LOC100341516
uniprot id: G1TDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9986:NEDD8
gene id: 9986:NEDD8
uniprot id: Q4PLJ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family.
messages: Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.
messages: Interacts with AHR; interaction is direct. Interacts with NUB1; interaction is direct.
messages: Nucleus
messages: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.

9986:LOC100125982
gene id: 9986:LOC100125982
uniprot id: G1T8W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9986:LOC100349744
gene id: 9986:LOC100349744
uniprot id: A0A5F9D4K3
uniprot id: G1TJP5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100355453
gene id: 9986:LOC100355453
uniprot id: G1TCF9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9986:LOC100350625
gene id: 9986:LOC100350625
uniprot id: B8K192
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100337967
gene id: 9986:LOC100337967
uniprot id: G1SWZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9986:LOC100342302
gene id: 9986:LOC100342302
uniprot id: A0A5F9DE55
uniprot id: G1SWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

9986:MFAP1
gene id: 9986:MFAP1
uniprot id: B7NZF5
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9986:LOC100346779
gene id: 9986:LOC100346779
uniprot id: G1T9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9986:LOC100356560
gene id: 9986:LOC100356560
uniprot id: G1T9V1
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9986:LOC100356317
gene id: 9986:LOC100356317
uniprot id: G1SDX7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100345298
gene id: 9986:LOC100345298
uniprot id: G1TMM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100356640
gene id: 9986:LOC100356640
uniprot id: G1SYW2
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344409
gene id: 9986:LOC100344409
uniprot id: G1T064
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100356902
gene id: 9986:LOC100356902
uniprot id: A0A5F9CKM6
uniprot id: A0A5F9DHR7
uniprot id: G1SJB0
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9986:LOC100355824
gene id: 9986:LOC100355824
uniprot id: G1SYU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9986:LOC100340005
gene id: 9986:LOC100340005
uniprot id: A0A5F9DMK1
uniprot id: G1SWL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9986:LOC100358371
gene id: 9986:LOC100358371
uniprot id: G1SDD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9986:LOC100348493
gene id: 9986:LOC100348493
uniprot id: G1T214
names: Similarity
messages: Belongs to the NUP210 family.

9986:LOC100350938
gene id: 9986:LOC100350938
uniprot id: A0A5F9CR05
uniprot id: A0A5F9DVZ5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9986:LOC100353449
gene id: 9986:LOC100353449
uniprot id: G1T5T4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9986:TFPI
gene id: 9986:TFPI
uniprot id: P19761
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
messages: Secreted
messages: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).

9986:LOC100358024
gene id: 9986:LOC100358024
uniprot id: G1T8Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9986:PGR
gene id: 9986:PGR
uniprot id: P06186
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-344 by ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts with GTF2B (By similarity).
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-293 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-387. Phosphorylation on Ser-102 and Ser-344 also requires induction by hormone. Basal phosphorylation on Ser-82, Ser-191 and Ser-399 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-399 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-293, but not at Ser-191, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-344 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-387, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-293 (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
messages: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-293 (By similarity).

9986:LOC100348554
gene id: 9986:LOC100348554
uniprot id: G1SJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9986:PPP1CB
gene id: 9986:PPP1CB
uniprot id: P62143
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R7 and PPP1R12C. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site (By similarity). Interacts with PPP1R12B (PubMed:9827534). Interacts with FOXP3 (By similarity). Interacts with RRP1B (By similarity). Interacts with SERPINE1. Interacts with LZTR1 (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity).
messages: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity). Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg.
messages: nucleolus
messages: nucleoplasm

9986:CAMK2G
gene id: 9986:CAMK2G
uniprot id: O77707
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9986:LOC100351188
gene id: 9986:LOC100351188
uniprot id: A0A5F9C1N6
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9986:LOC100348432
gene id: 9986:LOC100348432
uniprot id: A0A5F9CKP2
uniprot id: G1SZ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100358953
gene id: 9986:LOC100358953
uniprot id: G1SJ92
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339647
gene id: 9986:LOC100339647
uniprot id: A0A5F9D7G3
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9986:LOC100339267
gene id: 9986:LOC100339267
uniprot id: G1SJM1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100355727
gene id: 9986:LOC100355727
uniprot id: A0A5F9C893
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100349969
gene id: 9986:LOC100349969
uniprot id: A0A5F9DF11
uniprot id: G1TYJ9
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9986:LOC100346103
gene id: 9986:LOC100346103
uniprot id: G1TY34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:LOC100339108
gene id: 9986:LOC100339108
uniprot id: A0A5F9DAJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9986:LOC100354501
gene id: 9986:LOC100354501
uniprot id: G1T667
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9986:KEF51 p10
gene id: 9986:KEF51_p10
uniprot id: A0A3Q8UG40
uniprot id: P98049
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100357296
gene id: 9986:LOC100357296
uniprot id: G1SEI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9986:PCDHAC2
gene id: 9986:PCDHAC2
uniprot id: A0A5F9DJM8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9986:LOC100348055
gene id: 9986:LOC100348055
uniprot id: G1SQ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9986:LOC100348636
gene id: 9986:LOC100348636
uniprot id: G1TCD4
names: Similarity
messages: Belongs to the FAM114 family.

9986:LOC100357345
gene id: 9986:LOC100357345
uniprot id: G1SUE0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LPH
gene id: 9986:LPH
uniprot id: P09849
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the glycosyl hydrolase 1 family.
messages: Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:1388157). The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other (PubMed:1388157).
messages: Homodimer.
messages: N-glycosylated.
messages: Specifically expressed in small intestine.
messages: The glycosyl hydrolase-1 3/region III carries the phlorizin hydrolase/glycosylceramidase activities (By similarity). The initial assignment of the activities to different regions was revised by the authors using alternative approaches (PubMed:1388157, PubMed:9762914).
messages: The glycosyl hydrolase-1 4/region IV carries the lactase activity (By similarity). The initial assignment of the activities to different regions was revised by the authors using alternative approaches (PubMed:1388157, PubMed:9762914).

9986:LOC100356792
gene id: 9986:LOC100356792
uniprot id: G1SZH6
names: Similarity
messages: Belongs to the OSBP family.

9986:SLN
gene id: 9986:SLN
uniprot id: P42532
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sarcolipin family.
messages: Endoplasmic reticulum membrane
messages: Interacts with calcium ATPase ATP2A1/SERCA1 (PubMed:23362265, PubMed:23455422, PubMed:23455424). Interact with ATP2A2; the inhibition decreases ATP2A1 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2 (By similarity).
messages: Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:23362265, PubMed:9575189). Required for muscle-based, non-shivering thermogenesis (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: Skeletal muscle (at protein level).

9986:SGCG
gene id: 9986:SGCG
uniprot id: Q28646
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9986:LOC100339141
gene id: 9986:LOC100339141
uniprot id: G1TQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9986:LOC100355934
gene id: 9986:LOC100355934
uniprot id: G1SNI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9986:LOC100340366
gene id: 9986:LOC100340366
uniprot id: A0A5F9CIM5
uniprot id: G1SZ70
names: Similarity
messages: Belongs to the FRAS1 family.

9986:LOC100350021
gene id: 9986:LOC100350021
uniprot id: G1TVF3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9986:LOC100341436
gene id: 9986:LOC100341436
uniprot id: G1TL70
names: Similarity
messages: Belongs to the copine family.

9986:LOC100352149
gene id: 9986:LOC100352149
uniprot id: G1T857
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC103349323
gene id: 9986:LOC103349323
uniprot id: G1SSD0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100357809
gene id: 9986:LOC100357809
uniprot id: G1SZ35
names: Similarity
messages: Belongs to the SNF7 family.

9986:OR51S1
gene id: 9986:OR51S1
uniprot id: B8K149
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100351556
gene id: 9986:LOC100351556
uniprot id: G1TU94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9986:LOC100101590
gene id: 9986:LOC100101590
uniprot id: A0A5F9DIR2
uniprot id: G1SGX8
names: Similarity
messages: Belongs to the peptidase C14A family.

9986:LOC100337978
gene id: 9986:LOC100337978
uniprot id: G1SVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:SLC22A4
gene id: 9986:SLC22A4
uniprot id: B7NZK9
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9986:LOC100345217
gene id: 9986:LOC100345217
uniprot id: G1U437
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9986:ASB5
gene id: 9986:ASB5
uniprot id: A0A5F9CEQ4
uniprot id: Q862Z2
names: Domain
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: Expressed in endothelial and smooth muscle cells of collateral arteries as well as in satellite cells.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play a role in the initiation of arteriogenesis.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
messages: Up-regulated in growing collateral arteries.

9986:LOC100346466
gene id: 9986:LOC100346466
uniprot id: G1TB47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9986:LOC100339815
gene id: 9986:LOC100339815
uniprot id: G1SYG2
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100339011
gene id: 9986:LOC100339011
uniprot id: G1TDS5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9986:LOC100342194
gene id: 9986:LOC100342194
uniprot id: A0A5F9DS98
uniprot id: G1TYW6
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9986:ORYCUNV1R1541
gene id: 9986:ORYCUNV1R1541
uniprot id: G1TLS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357678
gene id: 9986:LOC100357678
uniprot id: G1SXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100341777
gene id: 9986:LOC100341777
uniprot id: G1TRR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9986:OR51M1
gene id: 9986:OR51M1
uniprot id: B8K180
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341029
gene id: 9986:LOC100341029
uniprot id: G1SJN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9986:GDF5
gene id: 9986:GDF5
uniprot id: B7NZI8
names: Similarity
messages: Belongs to the TGF-beta family.

9986:LOC100340414
gene id: 9986:LOC100340414
uniprot id: A0A5F9CP28
names: Subcellular Location Annotation
messages: Nucleus

9986:ORYCUNV1R1603
gene id: 9986:ORYCUNV1R1603
uniprot id: A0A5F9DC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354654
gene id: 9986:LOC100354654
uniprot id: G1TKA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100354225
gene id: 9986:LOC100354225
uniprot id: G1SZN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9986:LOC100355922
gene id: 9986:LOC100355922
uniprot id: G1T1M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9986:IL4
gene id: 9986:IL4
uniprot id: A5Z1F6
uniprot id: Q9MZR7
uniprot id: Q9MZR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9986:VDAC2
gene id: 9986:VDAC2
uniprot id: G1SWI3
uniprot id: P68003
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity).
messages: Interacts with hexokinases (By similarity). Interacts with ARMC12 in a TBC1D21-dependent manner (By similarity). Interacts with KLC3 (By similarity). Interacts with SPATA33 (By similarity). Interacts with PPP3CC in a SPATA33-dependent manner (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9986:LOC100342001
gene id: 9986:LOC100342001
uniprot id: A0A5F9C9I2
names: Subcellular Location Annotation
messages: Membrane

9986:TFIP11
gene id: 9986:TFIP11
uniprot id: A4UMC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Nucleus

9986:PPP3CA
gene id: 9986:PPP3CA
uniprot id: Q8HZN0
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9986:LOC100338691
gene id: 9986:LOC100338691
uniprot id: A0A5F9DAQ1
uniprot id: G1SJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9986:FAS
gene id: 9986:FAS
uniprot id: Q9XS60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100345484
gene id: 9986:LOC100345484
uniprot id: G1SJU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9986:LOC100357837
gene id: 9986:LOC100357837
uniprot id: A0A5F9CCZ8
uniprot id: A0A5F9CYH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9986:OLFR594
gene id: 9986:OLFR594
uniprot id: B8K161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339673
gene id: 9986:LOC100339673
uniprot id: A0A5F9DGG1
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353930
gene id: 9986:LOC100353930
uniprot id: G1SFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9986:SERPINB7
gene id: 9986:SERPINB7
uniprot id: B7NZ98
names: Similarity
messages: Belongs to the serpin family.

9986:EIF2S2
gene id: 9986:EIF2S2
uniprot id: P41035
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity).
messages: The N-terminus is blocked.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

9986:LOC100344900
gene id: 9986:LOC100344900
uniprot id: G1TBY4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9986:LOC100358101
gene id: 9986:LOC100358101
uniprot id: G1SZC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9986:LOC100352933
gene id: 9986:LOC100352933
uniprot id: G1TVP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9986:LOC100357936
gene id: 9986:LOC100357936
uniprot id: G1T156
names: Similarity
messages: Belongs to the peptidase S10 family.

9986:LOC100347394
gene id: 9986:LOC100347394
uniprot id: G1SUH1
names: Similarity
messages: Belongs to the intermediate filament family.

9986:PPP1CA
gene id: 9986:PPP1CA
uniprot id: P62139
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Detected in skeletal muscle (at protein level). Detected in skeletal muscle.
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R9A, PPP1R9B and PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site (By similarity). Interacts with PPP1R39. Interacts with NEK2. Interacts with PHACTR4; which acts as an activator of PP1 activity. Interacts with FER; this promotes phosphorylation at Thr-320 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts with FOXP3 (By similarity). Interacts with CENPA (By similarity). Interacts with ATG16L1 (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity). Interacts with tensin TNS1 (By similarity).
messages: Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
messages: nucleolus
messages: nucleoplasm

9986:LOC100338784
gene id: 9986:LOC100338784
uniprot id: A0A5F9D390
uniprot id: G1T276
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9986:LOC100359207
gene id: 9986:LOC100359207
uniprot id: G1SRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9986:LOC100354017
gene id: 9986:LOC100354017
uniprot id: G1T365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9986:LOC100349411
gene id: 9986:LOC100349411
uniprot id: G1TR15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9986:HTR5BP
gene id: 9986:HTR5BP
uniprot id: B7NZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348497
gene id: 9986:LOC100348497
uniprot id: G1SIX2
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9986:LOC100354345
gene id: 9986:LOC100354345
uniprot id: G1SJR7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346614
gene id: 9986:LOC100346614
uniprot id: G1TC69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9986:LOC100342215
gene id: 9986:LOC100342215
uniprot id: A0A5F9CKC4
uniprot id: G1SGP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane

9986:LOC100355348
gene id: 9986:LOC100355348
uniprot id: A0A5F9CX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100337882
gene id: 9986:LOC100337882
uniprot id: A0A5F9C540
uniprot id: G1SI32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9986:SELE
gene id: 9986:SELE
uniprot id: P27113
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: By cytokines.
messages: Cell membrane
messages: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
messages: Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.

9986:LOC100352170
gene id: 9986:LOC100352170
uniprot id: G1SZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9986:LOC100353965
gene id: 9986:LOC100353965
uniprot id: G1SFA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9986:LOC100342116
gene id: 9986:LOC100342116
uniprot id: G1T0T0
names: Subcellular Location Annotation
messages: Nucleus

9986:RARS1
gene id: 9986:RARS1
uniprot id: G1TA11
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:LOC100355061
gene id: 9986:LOC100355061
uniprot id: G1TG33
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100352248
gene id: 9986:LOC100352248
uniprot id: A0A5F9DQE9
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9986:LOC108178019
gene id: 9986:LOC108178019
uniprot id: G1SHQ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9986:LOC100351416
gene id: 9986:LOC100351416
uniprot id: G1SHP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:LOC100353612
gene id: 9986:LOC100353612
uniprot id: G1U380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353609
gene id: 9986:LOC100353609
uniprot id: G1SZ43
names: Subcellular Location Annotation
messages: Membrane

9986:HCN4
gene id: 9986:HCN4
uniprot id: Q9TV66
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by cAMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening.
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Highly expressed in the heart sinoatrial node (SAN). Not detected in atrium, ventricle, forebrain or cerebellum. Detected at very low levels in total brain.
messages: Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits (By similarity).
messages: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
messages: Inhibited by extracellular cesium ions.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9986:LOC100342269
gene id: 9986:LOC100342269
uniprot id: G1SWT5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:LOC100339221
gene id: 9986:LOC100339221
uniprot id: G1TCA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9986:LOC100350186
gene id: 9986:LOC100350186
uniprot id: U3KPA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9986:LOC100342476
gene id: 9986:LOC100342476
uniprot id: A0A5F9CKU9
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9986:LOC100345101
gene id: 9986:LOC100345101
uniprot id: G1TW40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352347
gene id: 9986:LOC100352347
uniprot id: W0UVE4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:LOC100340945
gene id: 9986:LOC100340945
uniprot id: G1SRI8
names: Similarity
messages: Belongs to the hexokinase family.

9986:LOC100340999
gene id: 9986:LOC100340999
uniprot id: G1TCU6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339732
gene id: 9986:LOC100339732
uniprot id: G1SPB4
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9986:LOC100353399
gene id: 9986:LOC100353399
uniprot id: G1TRI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340396
gene id: 9986:LOC100340396
uniprot id: A0A5F9CBX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9986:LOC100352912
gene id: 9986:LOC100352912
uniprot id: G1TPY3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100347181
gene id: 9986:LOC100347181
uniprot id: G1TEW4
names: Similarity
messages: Belongs to the peptidase C19 family.

9986:LOC100343709
gene id: 9986:LOC100343709
uniprot id: A0A5F9DT34
uniprot id: G1T1J7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9986:LOC100354110
gene id: 9986:LOC100354110
uniprot id: G1SE59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9986:LOC100353963
gene id: 9986:LOC100353963
uniprot id: G1T606
names: Similarity
messages: Belongs to the FAM20 family.

9986:LOC100359216
gene id: 9986:LOC100359216
uniprot id: G1TWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9986:LOC100351415
gene id: 9986:LOC100351415
uniprot id: A0A5F9D4V1
uniprot id: G1TYM8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100342690
gene id: 9986:LOC100342690
uniprot id: G1SZD5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343825
gene id: 9986:LOC100343825
uniprot id: G1T7P2
names: Subcellular Location Annotation
messages: sarcolemma

9986:LOC100357547
gene id: 9986:LOC100357547
uniprot id: G1SPI6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9986:LOC100348774
gene id: 9986:LOC100348774
uniprot id: G1SP85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9986:RGS4
gene id: 9986:RGS4
uniprot id: E5D0D3
uniprot id: Q0R4E4
names: Function
names: PTM
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
messages: Palmitoylated on Cys-2 and/or Cys-12.
messages: Phosphorylated by cyclic GMP-dependent protein kinase.

9986:LOC100350421
gene id: 9986:LOC100350421
uniprot id: G1U4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9986:ANKRD1
gene id: 9986:ANKRD1
uniprot id: Q9TU71
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Down-regulated by doxorubicin (adriamycin), in vitro.
messages: Interacts with TTN/titin and YBX1.
messages: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity).
messages: Nucleus

9986:LOC100339454
gene id: 9986:LOC100339454
uniprot id: G1TWZ0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:LOC100340905
gene id: 9986:LOC100340905
uniprot id: G1U1T8
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9986:LOC100357321
gene id: 9986:LOC100357321
uniprot id: G1SGN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9986:LOC100352685
gene id: 9986:LOC100352685
uniprot id: G1SQ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9986:LOC100347822
gene id: 9986:LOC100347822
uniprot id: G1TD18
names: Similarity
messages: Belongs to the TTC39 family.

9986:LOC100352672
gene id: 9986:LOC100352672
uniprot id: A0A5F9DE57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:OLR94
gene id: 9986:OLR94
uniprot id: B8K190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340592
gene id: 9986:LOC100340592
uniprot id: G1T9Q7
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9986:LOC100350273
gene id: 9986:LOC100350273
uniprot id: G1SHS1
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9986:LOC100358633
gene id: 9986:LOC100358633
uniprot id: G1SD32
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340006
gene id: 9986:LOC100340006
uniprot id: G1TCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9986:LOC100344853
gene id: 9986:LOC100344853
uniprot id: G1SP57
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354287
gene id: 9986:LOC100354287
uniprot id: G1TH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9986:LOC100344758
gene id: 9986:LOC100344758
uniprot id: G1SH58
names: Similarity
messages: Belongs to the peptidase M14 family.

9986:LOC100358430
gene id: 9986:LOC100358430
uniprot id: G1TX30
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100352311
gene id: 9986:LOC100352311
uniprot id: G1SDA4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9986:LOC100342479
gene id: 9986:LOC100342479
uniprot id: G1SZ33
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:CRH
gene id: 9986:CRH
uniprot id: A0A5F9DQ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9986:LOC100356581
gene id: 9986:LOC100356581
uniprot id: A0A5F9DE12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100341780
gene id: 9986:LOC100341780
uniprot id: G1TSY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:LOC100352116
gene id: 9986:LOC100352116
uniprot id: G1SLB3
names: Similarity
messages: Belongs to the syntaxin family.

9986:C3H5orf63
gene id: 9986:C3H5orf63
uniprot id: G1TAD3
names: Similarity
messages: Belongs to the glutaredoxin family.

9986:LOC100343670
gene id: 9986:LOC100343670
uniprot id: A0A5F9DTS9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100009314
gene id: 9986:LOC100009314
uniprot id: A0A5F9D237
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:SEPTIN6
gene id: 9986:SEPTIN6
uniprot id: A0A5F9C100
uniprot id: A0A5F9CTB8
uniprot id: A0A5F9CVS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9986:LOC100344560
gene id: 9986:LOC100344560
uniprot id: G1SYE9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9986:LOC100357071
gene id: 9986:LOC100357071
uniprot id: G1TDS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9986:LOC100342795
gene id: 9986:LOC100342795
uniprot id: G1T0T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9986:LOC100009456
gene id: 9986:LOC100009456
uniprot id: G1TBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9986:ORYCUNV1R1532
gene id: 9986:ORYCUNV1R1532
uniprot id: A0A5F9DUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340626
gene id: 9986:LOC100340626
uniprot id: G1SZ49
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9986:LOC100344833
gene id: 9986:LOC100344833
uniprot id: G1STX8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9986:LOC100347428
gene id: 9986:LOC100347428
uniprot id: G1T9M7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9986:LOC100357679
gene id: 9986:LOC100357679
uniprot id: G1U7C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9986:LOC100345211
gene id: 9986:LOC100345211
uniprot id: G1SW78
names: Similarity
messages: Belongs to the SNF7 family.

9986:LOC100349006
gene id: 9986:LOC100349006
uniprot id: G1SW62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9986:LOC100357680
gene id: 9986:LOC100357680
uniprot id: G1T753
names: Subcellular Location Annotation
messages: nucleolus

9986:LOC100341880
gene id: 9986:LOC100341880
uniprot id: G1U4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

9986:LOC100349259
gene id: 9986:LOC100349259
uniprot id: A0A5F9DGS3
uniprot id: G1SG68
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9986:LOC100339302
gene id: 9986:LOC100339302
uniprot id: G1SF59
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9986:LOC100339660
gene id: 9986:LOC100339660
uniprot id: A0A5F9CA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9986:LOC103348328
gene id: 9986:LOC103348328
uniprot id: G1TFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:ST3GAL4
gene id: 9986:ST3GAL4
uniprot id: G1T3I8
uniprot id: Q9N257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100338648
gene id: 9986:LOC100338648
uniprot id: G1STE5
names: Similarity
messages: Belongs to the Amer family.

9986:LOC100359025
gene id: 9986:LOC100359025
uniprot id: G1SES7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100357064
gene id: 9986:LOC100357064
uniprot id: G1SRK6
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9986:LOC100340548
gene id: 9986:LOC100340548
uniprot id: G1T6S2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9986:LOC100144336
gene id: 9986:LOC100144336
uniprot id: G1SRJ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9986:LOC100344273
gene id: 9986:LOC100344273
uniprot id: G1SMQ9
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9986:LOC100347595
gene id: 9986:LOC100347595
uniprot id: A0A5F9CV83
uniprot id: G1THZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9986:LOC100339919
gene id: 9986:LOC100339919
uniprot id: G1TDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344339
gene id: 9986:LOC100344339
uniprot id: G1T4M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9986:CHRM4
gene id: 9986:CHRM4
uniprot id: A0A5F9DUN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9986:PLAU
gene id: 9986:PLAU
uniprot id: Q8MHY7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR. In complex with SERPINE1, interacts with PLAUR/uPAR. Interacts with SORL1 and LRP1, either alone or in complex with SERPINE1; these interactions are abolished in the presence of LRPAP1/RAP. The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORLA.
messages: Inhibited by SERPINA5.
messages: Phosphorylation of Ser-325 abolishes proadhesive ability but does not interfere with receptor binding.
messages: Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
messages: Secreted
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9986:LOC100340587
gene id: 9986:LOC100340587
uniprot id: G1SXM0
names: Similarity
messages: Belongs to the tubulin family.

9986:RPS20
gene id: 9986:RPS20
uniprot id: G1SIZ2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9986:MMP1
gene id: 9986:MMP1
uniprot id: P13943
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Can be activated without removal of the activation peptide.
messages: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Tyrosine phosphorylated in platelets by PKDCC/VLK.
messages: extracellular matrix

9986:LOC100356612
gene id: 9986:LOC100356612
uniprot id: G1SCI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9986:LOC100354603
gene id: 9986:LOC100354603
uniprot id: G1T0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9986:LOC100357575
gene id: 9986:LOC100357575
uniprot id: G1U0R7
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9986:LOC100357889
gene id: 9986:LOC100357889
uniprot id: G1SGP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340852
gene id: 9986:LOC100340852
uniprot id: A0A5F9CZ01
names: Similarity
messages: Belongs to the PP2C family.

9986:LOC100347029
gene id: 9986:LOC100347029
uniprot id: A0A5F9CMV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

9986:LOC100344988
gene id: 9986:LOC100344988
uniprot id: G1SLI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9986:LOC100355433
gene id: 9986:LOC100355433
uniprot id: G1TE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9986:LOC100339241
gene id: 9986:LOC100339241
uniprot id: G1SIA3
names: Similarity
messages: Belongs to the helicase family.

9986:LOC100357153
gene id: 9986:LOC100357153
uniprot id: A0A5F9DF25
uniprot id: G1TGQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100337915
gene id: 9986:LOC100337915
uniprot id: G1T4R3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100342906
gene id: 9986:LOC100342906
uniprot id: A0A5F9DRL2
names: Similarity
messages: Belongs to the pro/parathymosin family.

9986:LOC100358262
gene id: 9986:LOC100358262
uniprot id: G1SDC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9986:LOC100339177
gene id: 9986:LOC100339177
uniprot id: G1SHB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9986:LOC100348176
gene id: 9986:LOC100348176
uniprot id: A0A5F9CCS2
uniprot id: A0A5F9DPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9986:LOC100342066
gene id: 9986:LOC100342066
uniprot id: G1TUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9986:LOC100358026
gene id: 9986:LOC100358026
uniprot id: G1TBR9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100340491
gene id: 9986:LOC100340491
uniprot id: G1SKB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9986:LOC100340813
gene id: 9986:LOC100340813
uniprot id: A0A5F9DI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100351879
gene id: 9986:LOC100351879
uniprot id: G1SLV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:WASHC3
gene id: 9986:WASHC3
uniprot id: G1T8V9
names: Similarity
messages: Belongs to the CCDC53 family.

9986:LOC100352421
gene id: 9986:LOC100352421
uniprot id: A0A5F9C306
uniprot id: A0A5F9D5B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9986:LOC100352232
gene id: 9986:LOC100352232
uniprot id: A0A5F9DJ00
uniprot id: G1SKE5
names: Similarity
messages: Belongs to the LAMTOR4 family.

9986:LOC100353806
gene id: 9986:LOC100353806
uniprot id: G1T845
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9986:LOC100343959
gene id: 9986:LOC100343959
uniprot id: G1SWN5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340667
gene id: 9986:LOC100340667
uniprot id: G1TWN8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100338588
gene id: 9986:LOC100338588
uniprot id: G1SFN1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9986:LOC100340579
gene id: 9986:LOC100340579
uniprot id: A0A5F9D095
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100356542
gene id: 9986:LOC100356542
uniprot id: A0A5F9CBF6
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9986:MIX23
gene id: 9986:MIX23
uniprot id: A0A5F9D8N9
names: Similarity
messages: Belongs to the MIX23 family.

9986:LOC100351584
gene id: 9986:LOC100351584
uniprot id: G1T635
names: Subcellular Location Annotation
messages: PML body

9986:KEF51 p05
gene id: 9986:KEF51_p05
uniprot id: A0A3Q8UF63
uniprot id: O79435
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100343855
gene id: 9986:LOC100343855
uniprot id: G1SD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9986:LOC100346567
gene id: 9986:LOC100346567
uniprot id: G1SHX3
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9986:LOC100344331
gene id: 9986:LOC100344331
uniprot id: U3KP58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100349629
gene id: 9986:LOC100349629
uniprot id: G1SJY5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100337970
gene id: 9986:LOC100337970
uniprot id: G1SWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342994
gene id: 9986:LOC100342994
uniprot id: G1SRP8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9986:ALDOA
gene id: 9986:ALDOA
uniprot id: A0A5F9D5U7
uniprot id: P00883
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alkylation of Arg-43 inactivates the enzyme.
messages: Asn-361 in form alpha is deaminated to Asp in form beta.
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer. Interacts with SNX9 and WAS. Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+).
messages: I band
messages: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
messages: M line
messages: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.

9986:LOC100338424
gene id: 9986:LOC100338424
uniprot id: G1TJP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space

9986:LOC100352341
gene id: 9986:LOC100352341
uniprot id: G1SKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9986:LOC100346343
gene id: 9986:LOC100346343
uniprot id: G1TL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341770
gene id: 9986:LOC100341770
uniprot id: A0A5F9C749
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC108177320
gene id: 9986:LOC108177320
uniprot id: G1U0K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100337711
gene id: 9986:LOC100337711
uniprot id: A0A5F9D0E6
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

9986:LOC100358442
gene id: 9986:LOC100358442
uniprot id: G1SZJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9986:LOC100347249
gene id: 9986:LOC100347249
uniprot id: G1TY31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:CYP3A6
gene id: 9986:CYP3A6
uniprot id: P11707
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By rifampicin.
messages: Endoplasmic reticulum membrane
messages: Exhibits progesterone 6 beta-hydroxylase activity.
messages: Microsome membrane

9986:CFAP418
gene id: 9986:CFAP418
uniprot id: G1SEN4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9986:FAM83C
gene id: 9986:FAM83C
uniprot id: B7NZI6
names: Similarity
messages: Belongs to the FAM83 family.

9986:LOC100343536
gene id: 9986:LOC100343536
uniprot id: G1SNY0
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9986:LOC100352000
gene id: 9986:LOC100352000
uniprot id: G1SIU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:MYF5
gene id: 9986:MYF5
uniprot id: G1U1L5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9986:MAP2K1
gene id: 9986:MAP2K1
uniprot id: P29678
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Cytoplasm
messages: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis (By similarity).
messages: Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14 (By similarity). Forms a heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form tetramers (PubMed:21441910). Interacts with KSR1 or KSR2 and BRAF; the interaction with KSR1 or KSR2 mediates KSR1-BRAF or KSR2-BRAF dimerization (By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2 and RAF1 (By similarity). Interacts with MAPK1/ERK2 (By similarity). Interacts with MORG1 (By similarity). Interacts with PPARG (By similarity). Interacts with SGK1 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with KAT7; the interaction promotes KAT7 phosphorylation (By similarity). Interacts with RAF1 and NEK10; the interaction is required for ERK1/2-signaling pathway activation in response to UV irradiation (By similarity). Interacts with TRAF3IP3 (By similarity).
messages: Membrane
messages: Nucleus
messages: Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity (By similarity). Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK (By similarity). MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK (By similarity). Autophosphorylated at Ser-218 and Ser-222, autophosphosphorylation is promoted by NEK10 following UV irradiation (By similarity).
messages: Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222 (By similarity). MAP2K1/MEK1 binds KSR1 or KSR2 releasing the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains (By similarity). This allows KSR1 or KSR2 dimerization with BRAF leading to BRAF activation and phosphorylation of MAP2K1 (By similarity). MAP2K1/MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A (By similarity).
messages: The proline-rich region localized between residues 270 and 307 is important for the binding to RAF1 and activation of MAP2K1/MEK1.
messages: centrosome
messages: spindle pole body

9986:ADH5
gene id: 9986:ADH5
uniprot id: O19053
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
messages: Cytoplasm
messages: Homodimer.

9986:LOC100342367
gene id: 9986:LOC100342367
uniprot id: A0A5F9CG09
uniprot id: G1SY91
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9986:LOC100346393
gene id: 9986:LOC100346393
uniprot id: G1TN01
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9986:OLR136
gene id: 9986:OLR136
uniprot id: B8K181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:NGB
gene id: 9986:NGB
uniprot id: G1SPL8
uniprot id: Q6EV97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the globin family.
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity).
messages: Monomer. Homodimer and homotetramer; disulfide-linked.
messages: Perikaryon

9986:TNNC2
gene id: 9986:TNNC2
uniprot id: P02586
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Skeletal muscle troponin C binds four calcium ions.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9986:LOC100345543
gene id: 9986:LOC100345543
uniprot id: G1TFK4
names: Subcellular Location Annotation
messages: Nucleus

9986:AKR1D1
gene id: 9986:AKR1D1
uniprot id: Q9TV64
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).
messages: Cytoplasm
messages: Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM. Inhibited by the primary and secondary bile acids chenodeoxycholic acid and ursodeoxycholic acid.

9986:LOC100353281
gene id: 9986:LOC100353281
uniprot id: G1TWL0
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9986:LOC100353247
gene id: 9986:LOC100353247
uniprot id: G1SR60
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9986:LOC100349133
gene id: 9986:LOC100349133
uniprot id: G1TF14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9986:LOC100348935
gene id: 9986:LOC100348935
uniprot id: A0A5F9CZV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9986:LOC100342567
gene id: 9986:LOC100342567
uniprot id: A0A5F9C4P8
uniprot id: G1SR52
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:LOC100340644
gene id: 9986:LOC100340644
uniprot id: G1SUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9986:LOC100346048
gene id: 9986:LOC100346048
uniprot id: G1TGP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9986:TNFSF4
gene id: 9986:TNFSF4
uniprot id: A0A0U5J5S0
uniprot id: O02765
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
messages: Homotrimer.
messages: Membrane

9986:LOC100341107
gene id: 9986:LOC100341107
uniprot id: A0A5F9D1D3
uniprot id: G1U540
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9986:LOC100345568
gene id: 9986:LOC100345568
uniprot id: G1TSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350069
gene id: 9986:LOC100350069
uniprot id: A0A5F9D4C4
uniprot id: G1SK62
names: Similarity
messages: Belongs to the DCK/DGK family.

9986:LOC100352746
gene id: 9986:LOC100352746
uniprot id: A0A5F9DG61
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100342698
gene id: 9986:LOC100342698
uniprot id: G1TBZ1
names: Similarity
messages: Belongs to the ATG8 family.

9986:LOC100347889
gene id: 9986:LOC100347889
uniprot id: G1U2E3
names: Similarity
messages: Belongs to the SNF7 family.

9986:LOC100340748
gene id: 9986:LOC100340748
uniprot id: G1SVM1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9986:LOC100337826
gene id: 9986:LOC100337826
uniprot id: G1T132
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9986:LOC100342099
gene id: 9986:LOC100342099
uniprot id: A0A5F9DBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9986:LOC100354439
gene id: 9986:LOC100354439
uniprot id: G1T545
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9986:LOC100347755
gene id: 9986:LOC100347755
uniprot id: G1STV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9986:LOC100345786
gene id: 9986:LOC100345786
uniprot id: G1T4T0
names: Similarity
messages: Belongs to the BLOC1S2 family.

9986:LOC100347666
gene id: 9986:LOC100347666
uniprot id: G1TDU3
names: Similarity
messages: Belongs to the CAF1 family.

9986:IDH1
gene id: 9986:IDH1
uniprot id: A0A5F9CXT8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9986:LOC100351756
gene id: 9986:LOC100351756
uniprot id: A0A5F9DJT3
names: Similarity
messages: Belongs to the SMAP family.

9986:KRTAP6-1
gene id: 9986:KRTAP6-1
uniprot id: Q02957
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.
messages: KAP6 proteins are first expressed in differentiating hair shaft keratinocytes a considerable distance above the proliferative zone of the follicle bulb.

9986:LOC100350018
gene id: 9986:LOC100350018
uniprot id: G1TCY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9986:LOC103349644
gene id: 9986:LOC103349644
uniprot id: U3KP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9986:LOC100350735
gene id: 9986:LOC100350735
uniprot id: G1SKQ5
names: Similarity
messages: Belongs to the apolipoprotein L family.

9986:LOC100359059
gene id: 9986:LOC100359059
uniprot id: A0A5F9CCB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9986:LOC100355467
gene id: 9986:LOC100355467
uniprot id: G1SY59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9986:MMAA
gene id: 9986:MMAA
uniprot id: Q5MFW3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
messages: Cytoplasm
messages: GTPase activity is stimulated by MMUT.
messages: GTPase, binds and hydrolyzes GTP (By similarity). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (By similarity). Plays a dual role as both a protectase and a reactivase for MMUT (By similarity). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (By similarity). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (By similarity).
messages: Homodimer. Interacts with MMUT (the apoenzyme form); the interaction is GTP dependent.
messages: Mitochondrion

9986:LOC100359311
gene id: 9986:LOC100359311
uniprot id: G1SVQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100341093
gene id: 9986:LOC100341093
uniprot id: G1T361
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9986:LOC100349136
gene id: 9986:LOC100349136
uniprot id: G1U314
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:EIF2B2
gene id: 9986:EIF2B2
uniprot id: Q28690
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9986:LOC100350102
gene id: 9986:LOC100350102
uniprot id: G1TDF7
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:LOC100338969
gene id: 9986:LOC100338969
uniprot id: A0A5F9DTN4
uniprot id: G1TB34
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9986:LOC100353836
gene id: 9986:LOC100353836
uniprot id: G1U7S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9986:LOC100341871
gene id: 9986:LOC100341871
uniprot id: G1TIS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100355314
gene id: 9986:LOC100355314
uniprot id: G1SD73
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9986:LOC100340837
gene id: 9986:LOC100340837
uniprot id: G1SG78
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9986:LOC108177472
gene id: 9986:LOC108177472
uniprot id: G1TI36
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9986:LOC100343833
gene id: 9986:LOC100343833
uniprot id: G1SYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9986:LOC100340843
gene id: 9986:LOC100340843
uniprot id: G1TDA7
names: Similarity
messages: Belongs to the CEF1 family.

9986:LOC100338803
gene id: 9986:LOC100338803
uniprot id: G1TWB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9986:LOC100349758
gene id: 9986:LOC100349758
uniprot id: A0A5F9D588
uniprot id: A0A5F9DNM9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100354454
gene id: 9986:LOC100354454
uniprot id: G1SYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9986:LOC100144330
gene id: 9986:LOC100144330
uniprot id: G1TU43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100346075
gene id: 9986:LOC100346075
uniprot id: G1SVC6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100341009
gene id: 9986:LOC100341009
uniprot id: G1TF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

9986:LOC100348588
gene id: 9986:LOC100348588
uniprot id: A0A5F9DH82
uniprot id: G1SPX0
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9986:LOC100345598
gene id: 9986:LOC100345598
uniprot id: G1TB13
names: Subcellular Location Annotation
messages: cytosol

9986:LOC100354438
gene id: 9986:LOC100354438
uniprot id: A0A5F9C9E2
uniprot id: G1U072
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9986:LOC100343331
gene id: 9986:LOC100343331
uniprot id: G1U2S5
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9986:LOC100339003
gene id: 9986:LOC100339003
uniprot id: G1SME3
names: Similarity
messages: Belongs to the CLCR family.

9986:LOC100347527
gene id: 9986:LOC100347527
uniprot id: A0A5F9DUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9986:LOC100353615
gene id: 9986:LOC100353615
uniprot id: G1TA34
names: Subcellular Location Annotation
messages: Membrane

9986:SLC15A1
gene id: 9986:SLC15A1
uniprot id: P36836
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Intestine, kidney, liver and low in brain.
messages: Membrane
messages: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:8139693). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (PubMed:8139693).
messages: The extracellular domain (ECD) region specifically binds trypsin.

9986:LOC100358612
gene id: 9986:LOC100358612
uniprot id: G1SUP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9986:LOC100341008
gene id: 9986:LOC100341008
uniprot id: G1SRF6
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9986:LOC100349968
gene id: 9986:LOC100349968
uniprot id: G1T9I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9986:LOC100338404
gene id: 9986:LOC100338404
uniprot id: G1TM42
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9986:LOC100347523
gene id: 9986:LOC100347523
uniprot id: G1TDG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9986:LOC100353640
gene id: 9986:LOC100353640
uniprot id: G1U4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100356136
gene id: 9986:LOC100356136
uniprot id: G1TEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9986:BCLAF3
gene id: 9986:BCLAF3
uniprot id: G1T947
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9986:LOC100353921
gene id: 9986:LOC100353921
uniprot id: U3KM02
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9986:LOC100338156
gene id: 9986:LOC100338156
uniprot id: G1TC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9986:LOC100346078
gene id: 9986:LOC100346078
uniprot id: G1U0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357201
gene id: 9986:LOC100357201
uniprot id: G1U258
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100359300
gene id: 9986:LOC100359300
uniprot id: A0A5F9D9S7
uniprot id: G1T2E1
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9986:LOC100347843
gene id: 9986:LOC100347843
uniprot id: G1TEE3
names: Similarity
messages: Belongs to the SMEK family.

9986:LOC100349299
gene id: 9986:LOC100349299
uniprot id: G1T7X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.

9986:LOC100357908
gene id: 9986:LOC100357908
uniprot id: G1SJV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9986:LOC100350475
gene id: 9986:LOC100350475
uniprot id: G1SCP6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9986:LOC100344594
gene id: 9986:LOC100344594
uniprot id: A0A5F9CQG8
names: Similarity
messages: Belongs to the NOP10 family.

9986:LOC100357641
gene id: 9986:LOC100357641
uniprot id: G1T425
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9986:LOC100356830
gene id: 9986:LOC100356830
uniprot id: G1SMZ5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

9986:LOC100344429
gene id: 9986:LOC100344429
uniprot id: G1T780
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9986:LOC100349729
gene id: 9986:LOC100349729
uniprot id: G1SY53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9986:LOC100353481
gene id: 9986:LOC100353481
uniprot id: G1TUE0
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9986:LOC100349230
gene id: 9986:LOC100349230
uniprot id: G1SN35
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9986:LOC100340566
gene id: 9986:LOC100340566
uniprot id: G1T5K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9986:LOC100350765
gene id: 9986:LOC100350765
uniprot id: G1T2J5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100349166
gene id: 9986:LOC100349166
uniprot id: G1TBG1
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9986:LOC100342938
gene id: 9986:LOC100342938
uniprot id: G1SCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9986:LOC100350256
gene id: 9986:LOC100350256
uniprot id: G1SGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9986:NOS1
gene id: 9986:NOS1
uniprot id: O19132
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4 (By similarity). Interacts with SLC6A4. Interacts with VAC14 (By similarity). Interacts (via N-terminal domain) with DLG4 (via N-terminal tandem pair of PDZ domains). Interacts with SLC6A4. Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity).
messages: Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP (By similarity).
messages: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
messages: The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity).
messages: Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).
messages: dendritic spine
messages: sarcolemma

9986:LOC100344509
gene id: 9986:LOC100344509
uniprot id: G1SQ44
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9986:LOC100344207
gene id: 9986:LOC100344207
uniprot id: G1TEN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9986:LOC100340402
gene id: 9986:LOC100340402
uniprot id: G1SUN3
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100339352
gene id: 9986:LOC100339352
uniprot id: G1SVD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9986:LOC100350731
gene id: 9986:LOC100350731
uniprot id: G1T266
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9986:CAMP
gene id: 9986:CAMP
uniprot id: G1T9L4
uniprot id: P25230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity.
messages: Neutrophils.
messages: Secreted

9986:LOC100345158
gene id: 9986:LOC100345158
uniprot id: G1TJB9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354032
gene id: 9986:LOC100354032
uniprot id: A0A5F9D318
uniprot id: A0A5F9DRU6
uniprot id: G1TK12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100348186
gene id: 9986:LOC100348186
uniprot id: G1T366
names: Similarity
messages: Belongs to the lipin family.

9986:LOC100356015
gene id: 9986:LOC100356015
uniprot id: G1SLM3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9986:LOC100350036
gene id: 9986:LOC100350036
uniprot id: G1SX87
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100346144
gene id: 9986:LOC100346144
uniprot id: G1SQ59
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100340785
gene id: 9986:LOC100340785
uniprot id: G1TAM7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9986:LOC100338657
gene id: 9986:LOC100338657
uniprot id: A0A5F9CWC0
uniprot id: G1T358
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100357705
gene id: 9986:LOC100357705
uniprot id: G1SY07
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344800
gene id: 9986:LOC100344800
uniprot id: A0A5F9C822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339702
gene id: 9986:LOC100339702
uniprot id: G1TQI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100339871
gene id: 9986:LOC100339871
uniprot id: G1SX00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9986:LOC100338814
gene id: 9986:LOC100338814
uniprot id: A0A5F9C2B4
uniprot id: A0A5F9C7M3
uniprot id: A0A5F9CSS2
uniprot id: A0A5F9DEW8
uniprot id: G1SCF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

9986:LOC100359145
gene id: 9986:LOC100359145
uniprot id: A0A5F9CEX2
names: Similarity
messages: Belongs to the FAM20 family.

9986:LOC100351235
gene id: 9986:LOC100351235
uniprot id: G1T8X8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Membrane
messages: cis-Golgi network membrane

9986:LOC100353188
gene id: 9986:LOC100353188
uniprot id: G1THQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100349756
gene id: 9986:LOC100349756
uniprot id: G1TD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:SERPINB8
gene id: 9986:SERPINB8
uniprot id: B7NZA1
uniprot id: G1SRV5
names: Similarity
messages: Belongs to the serpin family.
messages: Belongs to the serpin family. Ov-serpin subfamily.

9986:LOC100349637
gene id: 9986:LOC100349637
uniprot id: G1U5S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339008
gene id: 9986:LOC100339008
uniprot id: U3KMI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9986:LOC100356906
gene id: 9986:LOC100356906
uniprot id: G1SY85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9986:LOC100358329
gene id: 9986:LOC100358329
uniprot id: G1SZ28
names: Subcellular Location Annotation
messages: Nucleus

9986:APOA5
gene id: 9986:APOA5
uniprot id: A0A5F9D6U2
uniprot id: B7NZL9
uniprot id: G1TX15
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9986:LOC100338986
gene id: 9986:LOC100338986
uniprot id: G1SV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100344962
gene id: 9986:LOC100344962
uniprot id: G1TBU4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100358366
gene id: 9986:LOC100358366
uniprot id: G1T4E6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:TMOD4
gene id: 9986:TMOD4
uniprot id: B7NZD0
names: Subcellular Location Annotation
messages: cytoskeleton

9986:MMP12
gene id: 9986:MMP12
uniprot id: P79227
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9986:CRYL1
gene id: 9986:CRYL1
uniprot id: P14755
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Cytoplasm
messages: Detected in eye lens, kidney, liver, heart, lung, brain and testis.
messages: Functions as crystallin in the rabbit eye lens. Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
messages: Homodimer.
messages: Inhibited by malonate and by inorganic phosphate.

9986:LOC100346698
gene id: 9986:LOC100346698
uniprot id: G1SXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:IL1A
gene id: 9986:IL1A
uniprot id: P04822
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

9986:LOC100341980
gene id: 9986:LOC100341980
uniprot id: A0A5F9DBV5
uniprot id: G1SD16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:OLFR555
gene id: 9986:OLFR555
uniprot id: B8K151
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100348001
gene id: 9986:LOC100348001
uniprot id: A0A5F9DF28
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9986:LOC100350578
gene id: 9986:LOC100350578
uniprot id: A0A5F9C7U7
uniprot id: G1SM15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9986:LOC100355866
gene id: 9986:LOC100355866
uniprot id: G1SHY5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100348518
gene id: 9986:LOC100348518
uniprot id: G1U4K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9986:LPL
gene id: 9986:LPL
uniprot id: D5FIT0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9986:LOC100357587
gene id: 9986:LOC100357587
uniprot id: G1TA23
names: Similarity
messages: Belongs to the Toll-like receptor family.

9986:ADORA1
gene id: 9986:ADORA1
uniprot id: P34970
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9986:LOC100346470
gene id: 9986:LOC100346470
uniprot id: G1SKD8
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9986:LOC100352197
gene id: 9986:LOC100352197
uniprot id: G1SM70
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9986:LOC100344850
gene id: 9986:LOC100344850
uniprot id: G1T6I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9986:ABITRAM
gene id: 9986:ABITRAM
uniprot id: G1SGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9986:LOC100350092
gene id: 9986:LOC100350092
uniprot id: G1TXD9
names: Subcellular Location Annotation
messages: ruffle membrane

9986:LOC100356285
gene id: 9986:LOC100356285
uniprot id: G1TKP1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100350737
gene id: 9986:LOC100350737
uniprot id: G1TWW0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9986:LOC100342306
gene id: 9986:LOC100342306
uniprot id: G1U207
names: Similarity
messages: Belongs to the syntaxin family.

9986:LOC100352168
gene id: 9986:LOC100352168
uniprot id: G1T5J9
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9986:LOC100351376
gene id: 9986:LOC100351376
uniprot id: G1T1N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:SCNN1B
gene id: 9986:SCNN1B
uniprot id: O97742
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
messages: Cytoplasmic vesicle membrane
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. Interacts with NEDD4 (via WW domains). Interacts with NEDD4L (via WW domains). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC.
messages: N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
messages: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

9986:LOC100009330
gene id: 9986:LOC100009330
uniprot id: G1ST54
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100356718
gene id: 9986:LOC100356718
uniprot id: G1SQB6
names: Similarity
messages: Belongs to the PNO1 family.

9986:LOC100356377
gene id: 9986:LOC100356377
uniprot id: G1SFH4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9986:LOC100357903
gene id: 9986:LOC100357903
uniprot id: G1SN12
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9986:LOC100354714
gene id: 9986:LOC100354714
uniprot id: G1TXG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9986:LOC100339644
gene id: 9986:LOC100339644
uniprot id: G1SZ11
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9986:LOC100347746
gene id: 9986:LOC100347746
uniprot id: G1SE02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100339785
gene id: 9986:LOC100339785
uniprot id: G1SR03
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:LOC100341228
gene id: 9986:LOC100341228
uniprot id: G1SD54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9986:CYP7A1
gene id: 9986:CYP7A1
uniprot id: P51542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (Probable). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (By similarity). Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: Detected in liver.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9986:LOC100338305
gene id: 9986:LOC100338305
uniprot id: A0A5F9DQY9
uniprot id: G1SG88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9986:LOC100340973
gene id: 9986:LOC100340973
uniprot id: G1U5V2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9986:LOC100347007
gene id: 9986:LOC100347007
uniprot id: A0A5F9C4A7
uniprot id: G1SL02
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9986:LOC100358069
gene id: 9986:LOC100358069
uniprot id: G1U344
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9986:ALB
gene id: 9986:ALB
uniprot id: P49065
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted

9986:LOC100356815
gene id: 9986:LOC100356815
uniprot id: G1SI08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9986:LOC100341372
gene id: 9986:LOC100341372
uniprot id: G1T890
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9986:LOC100357992
gene id: 9986:LOC100357992
uniprot id: G1SCE2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9986:LOC100354301
gene id: 9986:LOC100354301
uniprot id: G1SKU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9986:LOC100351714
gene id: 9986:LOC100351714
uniprot id: G1SZW5
names: Similarity
messages: Belongs to the BicD family.

9986:LOC100351997
gene id: 9986:LOC100351997
uniprot id: G1SHH7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100343166
gene id: 9986:LOC100343166
uniprot id: G1SLU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9986:CMKLR2
gene id: 9986:CMKLR2
uniprot id: G1U6P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9986:PITPNA
gene id: 9986:PITPNA
uniprot id: P48738
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
messages: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (By similarity). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by PKC in a calcium and phosphatidylserine-dependent manner.

9986:LOC100348124
gene id: 9986:LOC100348124
uniprot id: G1T7Z6
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9986:LOC100350628
gene id: 9986:LOC100350628
uniprot id: G1TTA3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100351156
gene id: 9986:LOC100351156
uniprot id: G1SV46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

9986:LOC100350286
gene id: 9986:LOC100350286
uniprot id: G1SI60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9986:CEMIP2
gene id: 9986:CEMIP2
uniprot id: G1SET5
names: Similarity
messages: Belongs to the CEMIP family.

9986:LOC100351094
gene id: 9986:LOC100351094
uniprot id: G1SUC4
names: Similarity
messages: Belongs to the NCBP3 family.

9986:LOC100350645
gene id: 9986:LOC100350645
uniprot id: G1SKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9986:CCR1
gene id: 9986:CCR1
uniprot id: Q9MYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100356204
gene id: 9986:LOC100356204
uniprot id: U3KPL1
names: Similarity
messages: Belongs to the ANKRD34 family.

9986:LOC100339175
gene id: 9986:LOC100339175
uniprot id: A0A5F9CJZ2
uniprot id: G1SDG5
names: Subcellular Location Annotation
messages: Nucleus

9986:COR51P3
gene id: 9986:COR51P3
uniprot id: B8K157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:PAK2
gene id: 9986:PAK2
uniprot id: Q29502
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure. Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active (By similarity).
messages: Cytoplasm
messages: During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.
messages: Full-length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate (By similarity).
messages: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with SCRIB. Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10. Interacts with RAC1 (By similarity).
messages: Membrane
messages: Nucleus
messages: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Phosphorylates CASP7, thereby preventing its activity. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity).
messages: Ubiquitinated, leading to its proteasomal degradation.
messages: perinuclear region

9986:LOC100356628
gene id: 9986:LOC100356628
uniprot id: G1T7M9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9986:LOC100353613
gene id: 9986:LOC100353613
uniprot id: G1T9G2
names: Similarity
messages: Belongs to the CLCR family.

9986:LOC100350826
gene id: 9986:LOC100350826
uniprot id: G1T1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9986:LOC100343925
gene id: 9986:LOC100343925
uniprot id: G1SMH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9986:LOC100338089
gene id: 9986:LOC100338089
uniprot id: G1TV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9986:LOC100350277
gene id: 9986:LOC100350277
uniprot id: G1T1U9
names: Similarity
messages: Belongs to the BRINP family.

9986:LOC100352339
gene id: 9986:LOC100352339
uniprot id: G1U206
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357495
gene id: 9986:LOC100357495
uniprot id: G1TFI4
names: Similarity
messages: Belongs to the NAC-beta family.

9986:LOC100345606
gene id: 9986:LOC100345606
uniprot id: A0A5F9DE89
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100355181
gene id: 9986:LOC100355181
uniprot id: A0A5F9CWA9
uniprot id: A0A5F9D1C1
uniprot id: A0A5F9DST1
uniprot id: G1T3D3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100355469
gene id: 9986:LOC100355469
uniprot id: G1SP98
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9986:LOC100350632
gene id: 9986:LOC100350632
uniprot id: A0A5F9CV98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9986:LOC100008824
gene id: 9986:LOC100008824
uniprot id: G1T6D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9986:LOC103348690
gene id: 9986:LOC103348690
uniprot id: G1T9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:STON1
gene id: 9986:STON1
uniprot id: G1SS54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

9986:LOC100346119
gene id: 9986:LOC100346119
uniprot id: G1SP77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9986:LOC100353964
gene id: 9986:LOC100353964
uniprot id: G1SDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9986:LOC100341067
gene id: 9986:LOC100341067
uniprot id: G1TTU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9986:LOC100346113
gene id: 9986:LOC100346113
uniprot id: G1SFQ3
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9986:LOC100341508
gene id: 9986:LOC100341508
uniprot id: G1SQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9986:LOC100342484
gene id: 9986:LOC100342484
uniprot id: G1SXJ9
names: Similarity
messages: Belongs to the NKAP family.

9986:LOC100353509
gene id: 9986:LOC100353509
uniprot id: G1SEM7
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9986:LOC100341375
gene id: 9986:LOC100341375
uniprot id: A0A5F9CM79
uniprot id: A0A5F9CQP7
uniprot id: G1TV28
names: Similarity
messages: Belongs to the WD repeat coronin family.

9986:LOC100349278
gene id: 9986:LOC100349278
uniprot id: G1TDS8
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9986:DHRS4
gene id: 9986:DHRS4
uniprot id: Q309Z5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100349415
gene id: 9986:LOC100349415
uniprot id: G1SKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9986:CCN6
gene id: 9986:CCN6
uniprot id: G1SXL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100345175
gene id: 9986:LOC100345175
uniprot id: G1U459
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100350584
gene id: 9986:LOC100350584
uniprot id: W0UVH3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:LOC100008640
gene id: 9986:LOC100008640
uniprot id: A0A127LXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

9986:LOC100344543
gene id: 9986:LOC100344543
uniprot id: A0A5F9CHN4
uniprot id: G1SJ45
names: Similarity
messages: Belongs to the TMEM9 family.

9986:LOC100348685
gene id: 9986:LOC100348685
uniprot id: G1TJW3
names: Subcellular Location Annotation
messages: Nucleus speckle

9986:LOC100354801
gene id: 9986:LOC100354801
uniprot id: G1T8F8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9986:LOC100358947
gene id: 9986:LOC100358947
uniprot id: G1TU78
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100353786
gene id: 9986:LOC100353786
uniprot id: A0A5F9CW93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100349474
gene id: 9986:LOC100349474
uniprot id: G1T6U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9986:LOC100359234
gene id: 9986:LOC100359234
uniprot id: A0A5F9C8Z2
uniprot id: A0A5F9CWI6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9986:LOC100353663
gene id: 9986:LOC100353663
uniprot id: A0A5F9D0P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9986:LOC103350801
gene id: 9986:LOC103350801
uniprot id: G1TD25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9986:CRYGS
gene id: 9986:CRYGS
uniprot id: A4L9I8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9986:LOC100355147
gene id: 9986:LOC100355147
uniprot id: G1TPA7
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100351232
gene id: 9986:LOC100351232
uniprot id: G1SEY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100340520
gene id: 9986:LOC100340520
uniprot id: G1TGQ5
names: Similarity
messages: Belongs to the CAS family.

9986:LOC100349675
gene id: 9986:LOC100349675
uniprot id: G1T330
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9986:ETF1
gene id: 9986:ETF1
uniprot id: P62497
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.
messages: Heterodimer of two subunits, one of which binds GTP (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (By similarity). Interacts with JMJD4 (By similarity). The ETF1-GSPT1 complex interacts with JMJD4 (By similarity).
messages: Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency.
messages: Methylated at Gln-185 by N6AMT1.

9986:LOC100356550
gene id: 9986:LOC100356550
uniprot id: G1SV98
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100348143
gene id: 9986:LOC100348143
uniprot id: G1SK87
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345745
gene id: 9986:LOC100345745
uniprot id: G1U187
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9986:F3
gene id: 9986:F3
uniprot id: P24055
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tissue factor family.
messages: Brain, heart.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9986:LOC100355284
gene id: 9986:LOC100355284
uniprot id: G1SVB3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9986:LOC100344868
gene id: 9986:LOC100344868
uniprot id: G1T976
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100346111
gene id: 9986:LOC100346111
uniprot id: G1SR48
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9986:LOC100344765
gene id: 9986:LOC100344765
uniprot id: G1SN36
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350747
gene id: 9986:LOC100350747
uniprot id: G1T061
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9986:LOC100354213
gene id: 9986:LOC100354213
uniprot id: G1T3U7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9986:LOC100346423
gene id: 9986:LOC100346423
uniprot id: G1TDJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9986:LOC100349876
gene id: 9986:LOC100349876
uniprot id: G1TCU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

9986:LOC100341969
gene id: 9986:LOC100341969
uniprot id: G1SIJ7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9986:ADRA2A
gene id: 9986:ADRA2A
uniprot id: Q5ZQK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:MGAT1
gene id: 9986:MGAT1
uniprot id: P27115
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Interacts with MGAT4D. Interacts with BRI3 (By similarity).
messages: The cofactor is mostly bound to the substrate.
messages: perinuclear region

9986:LOC100354177
gene id: 9986:LOC100354177
uniprot id: G1SGS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9986:NFS1
gene id: 9986:NFS1
uniprot id: B7NZJ3
uniprot id: G1TCX0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9986:LOC100354910
gene id: 9986:LOC100354910
uniprot id: A0A7R8C3N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100340562
gene id: 9986:LOC100340562
uniprot id: G1TLC0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9986:LOC100340132
gene id: 9986:LOC100340132
uniprot id: G1U7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9986:LOC100348023
gene id: 9986:LOC100348023
uniprot id: G1SI74
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9986:LOC100349229
gene id: 9986:LOC100349229
uniprot id: G1T069
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9986:S100B
gene id: 9986:S100B
uniprot id: G1SFI2
uniprot id: Q6YNR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with CACYBP in a calcium-dependent manner. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity).
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

9986:FOXP2
gene id: 9986:FOXP2
uniprot id: A9UCM9
names: Subcellular Location Annotation
messages: Nucleus

9986:MINAR2
gene id: 9986:MINAR2
uniprot id: G1THP5
names: Similarity
messages: Belongs to the MINAR family.

9986:LOC100348972
gene id: 9986:LOC100348972
uniprot id: G1T7F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Membrane
messages: cytoskeleton

9986:LOC100348331
gene id: 9986:LOC100348331
uniprot id: G1TCC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9986:LOC100355199
gene id: 9986:LOC100355199
uniprot id: G1T9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9986:LOC100354296
gene id: 9986:LOC100354296
uniprot id: A0A5F9DT53
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9986:LOC100339605
gene id: 9986:LOC100339605
uniprot id: A0A5F9C3B2
uniprot id: A0A5F9DGM1
uniprot id: A0A5F9DKG3
uniprot id: G1SKU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100344644
gene id: 9986:LOC100344644
uniprot id: G1SWQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9986:LOC100344965
gene id: 9986:LOC100344965
uniprot id: G1U8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9986:LOC100347271
gene id: 9986:LOC100347271
uniprot id: G1T1U7
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9986:SOD3
gene id: 9986:SOD3
uniprot id: P41975
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer. Directly interacts with ATP7A; this interaction is copper-dependent and is required for SOD3 activity.
messages: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
messages: extracellular space
messages: trans-Golgi network

9986:LOC100350058
gene id: 9986:LOC100350058
uniprot id: G1T0Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100338847
gene id: 9986:LOC100338847
uniprot id: G1SPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9986:LOC100353464
gene id: 9986:LOC100353464
uniprot id: G1SFQ8
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100009305
gene id: 9986:LOC100009305
uniprot id: A0A5F9CEA8
uniprot id: G1T112
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9986:LOC100353662
gene id: 9986:LOC100353662
uniprot id: G1T6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9986:LOC100339986
gene id: 9986:LOC100339986
uniprot id: G1TD21
names: Similarity
messages: Belongs to the CFAP53 family.

9986:LOC100354220
gene id: 9986:LOC100354220
uniprot id: G1SDL5
names: Similarity
messages: Belongs to the PIGH family.

9986:LOC100356070
gene id: 9986:LOC100356070
uniprot id: G1TQC1
names: Similarity
messages: Belongs to the profilin family.

9986:LOC100353441
gene id: 9986:LOC100353441
uniprot id: G1T7Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9986:LOC100356889
gene id: 9986:LOC100356889
uniprot id: G1SVJ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

9986:LOC100346398
gene id: 9986:LOC100346398
uniprot id: A0A5F9D5S2
uniprot id: A0A5F9D853
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9986:LOC100353026
gene id: 9986:LOC100353026
uniprot id: G1T9S7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100344041
gene id: 9986:LOC100344041
uniprot id: G1SF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357673
gene id: 9986:LOC100357673
uniprot id: G1TD55
names: Similarity
messages: Belongs to the neutral ceramidase family.

9986:LOC100355174
gene id: 9986:LOC100355174
uniprot id: A0A5F9CJP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100358889
gene id: 9986:LOC100358889
uniprot id: G1U2Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

9986:LOC100350890
gene id: 9986:LOC100350890
uniprot id: G1SXX1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345865
gene id: 9986:LOC100345865
uniprot id: G1TBD0
names: Subcellular Location Annotation
messages: Secreted

9986:LOC100354120
gene id: 9986:LOC100354120
uniprot id: G1SVZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9986:LOC100353508
gene id: 9986:LOC100353508
uniprot id: A0A5F9CC70
uniprot id: A0A5F9CNC2
uniprot id: A0A5F9D2U5
uniprot id: A0A5F9DUF4
uniprot id: A0A5F9DUU2
uniprot id: G1SMX1
uniprot id: G1U0L6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9986:LOC100353027
gene id: 9986:LOC100353027
uniprot id: G1SX53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100354524
gene id: 9986:LOC100354524
uniprot id: A0A5F9CHE7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9986:LALBA
gene id: 9986:LALBA
uniprot id: A0A077S6N7
uniprot id: P00716
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Mammary gland specific. Secreted in milk.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
messages: Secreted

9986:LOC100345783
gene id: 9986:LOC100345783
uniprot id: A0A5F9DA97
uniprot id: G1T835
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9986:LOC100338296
gene id: 9986:LOC100338296
uniprot id: G1U5D3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:TAC4
gene id: 9986:TAC4
uniprot id: Q6ECK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9986:LOC100344142
gene id: 9986:LOC100344142
uniprot id: G1T3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: neuron projection
messages: trans-Golgi network

9986:YWHAH
gene id: 9986:YWHAH
uniprot id: B7NZM8
names: Similarity
messages: Belongs to the 14-3-3 family.

9986:C8H12orf57
gene id: 9986:C8H12orf57
uniprot id: G1T530
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9986:SEPTIN4
gene id: 9986:SEPTIN4
uniprot id: A0A5F9CMY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9986:HOXA1
gene id: 9986:HOXA1
uniprot id: B7NZT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9986:LOC100350165
gene id: 9986:LOC100350165
uniprot id: G1T438
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100356191
gene id: 9986:LOC100356191
uniprot id: G1SYZ6
names: Similarity
messages: Belongs to the TMEM106 family.

9986:LOC100358386
gene id: 9986:LOC100358386
uniprot id: G1SMQ1
names: Similarity
messages: Belongs to the angiomotin family.

9986:LOC100351930
gene id: 9986:LOC100351930
uniprot id: G1TZL1
names: Similarity
messages: Belongs to the SPSB family.

9986:LOC100101605
gene id: 9986:LOC100101605
uniprot id: G1T0W4
names: Similarity
messages: Belongs to the peptidase M10A family.

9986:LOC100344904
gene id: 9986:LOC100344904
uniprot id: G1T402
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9986:LOC100344001
gene id: 9986:LOC100344001
uniprot id: G1TAU2
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9986:LOC100009009
gene id: 9986:LOC100009009
uniprot id: A0A5F9DPM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100337816
gene id: 9986:LOC100337816
uniprot id: G1TB49
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9986:TAFA1
gene id: 9986:TAFA1
uniprot id: A0A5F9DBS5
names: Similarity
messages: Belongs to the TAFA family.

9986:LOC100350473
gene id: 9986:LOC100350473
uniprot id: G1TCU5
uniprot id: U3KMA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9986:LOC100101588
gene id: 9986:LOC100101588
uniprot id: A0A5F9DPF5
names: Similarity
messages: Belongs to the peptidase C14A family.

9986:LOC100356799
gene id: 9986:LOC100356799
uniprot id: G1TLE4
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9986:CCN4
gene id: 9986:CCN4
uniprot id: G1TBI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100346548
gene id: 9986:LOC100346548
uniprot id: G1TEV0
names: Similarity
messages: Belongs to the GORAB family.

9986:LOC100349760
gene id: 9986:LOC100349760
uniprot id: A0A5F9CS47
names: Similarity
messages: Belongs to the themis family.

9986:LOC100359058
gene id: 9986:LOC100359058
uniprot id: A0A5F9C904
names: Similarity
messages: Belongs to the TFIIB family.

9986:LOC100342516
gene id: 9986:LOC100342516
uniprot id: G1SEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:HJV
gene id: 9986:HJV
uniprot id: G1SQJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9986:LOC100358937
gene id: 9986:LOC100358937
uniprot id: G1SQC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9986:LOC108175354
gene id: 9986:LOC108175354
uniprot id: G1SML9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100343675
gene id: 9986:LOC100343675
uniprot id: A0A5F9C495
uniprot id: A0A5F9CTZ8
uniprot id: A0A5F9D2I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

9986:LOC100337721
gene id: 9986:LOC100337721
uniprot id: A0A5F9DT58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9986:LOC100352511
gene id: 9986:LOC100352511
uniprot id: G1TI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9986:LOC100352047
gene id: 9986:LOC100352047
uniprot id: G1SU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100356689
gene id: 9986:LOC100356689
uniprot id: G1SL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9986:LOC100342446
gene id: 9986:LOC100342446
uniprot id: G1TY75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9986:LOC100338412
gene id: 9986:LOC100338412
uniprot id: G1SRE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9986:EIF2B4
gene id: 9986:EIF2B4
uniprot id: P41111
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9986:LOC100338763
gene id: 9986:LOC100338763
uniprot id: G1T175
names: Subcellular Location Annotation
messages: cilium axoneme

9986:LOC100351633
gene id: 9986:LOC100351633
uniprot id: G1TJQ3
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100338331
gene id: 9986:LOC100338331
uniprot id: G1SRW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9986:LOC100342535
gene id: 9986:LOC100342535
uniprot id: G1TSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9986:LOC100347497
gene id: 9986:LOC100347497
uniprot id: G1SUG1
names: Similarity
messages: Belongs to the OXR1 family.

9986:LOC100340898
gene id: 9986:LOC100340898
uniprot id: G1SSM3
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9986:GRO-A
gene id: 9986:GRO-A
uniprot id: Q28724
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9986:SLC26A5
gene id: 9986:SLC26A5
uniprot id: B5TGH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

9986:LOC103350744
gene id: 9986:LOC103350744
uniprot id: G1SEU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9986:LOC100355397
gene id: 9986:LOC100355397
uniprot id: G1T1R8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9986:LOC100341265
gene id: 9986:LOC100341265
uniprot id: A0A5F9CXK3
names: Similarity
messages: Belongs to the BORA family.

9986:LOC100349921
gene id: 9986:LOC100349921
uniprot id: G1TPG3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9986:LOC100349785
gene id: 9986:LOC100349785
uniprot id: G1SLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9986:MINDY3
gene id: 9986:MINDY3
uniprot id: A0A5F9DTL2
uniprot id: G1TBX9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9986:CCL4
gene id: 9986:CCL4
uniprot id: G1TRQ1
uniprot id: P46632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Homodimer.
messages: Monokine with inflammatory and chemokinetic properties.
messages: Secreted

9986:LOC100354956
gene id: 9986:LOC100354956
uniprot id: A0A5F9CMH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100347973
gene id: 9986:LOC100347973
uniprot id: A0A5F9D3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9986:LOC100346547
gene id: 9986:LOC100346547
uniprot id: G1TV25
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9986:LOC100346860
gene id: 9986:LOC100346860
uniprot id: G1SSF9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9986:LOC100348476
gene id: 9986:LOC100348476
uniprot id: A0A5F9CJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9986:LOC100347987
gene id: 9986:LOC100347987
uniprot id: G1T7D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Binds TFR through the extracellular domain in a pH-dependent manner.
messages: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
messages: Cell membrane
messages: Membrane

9986:LOC100350339
gene id: 9986:LOC100350339
uniprot id: A0A5F9DRL2
names: Similarity
messages: Belongs to the pro/parathymosin family.

9986:LOC100353246
gene id: 9986:LOC100353246
uniprot id: A0A5F9D2V7
uniprot id: G1SDW1
names: Similarity
messages: Belongs to the FAM161 family.

9986:LOC100009591
gene id: 9986:LOC100009591
uniprot id: G1SSP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9986:PLB1
gene id: 9986:PLB1
uniprot id: Q05017
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (PubMed:8509424). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (PubMed:8509424). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (PubMed:8509424). May also hydrolyze long chain retinyl esters such as retinyl palmitate (Probable). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (Probable).
messages: Expressed in the intestine of adult but not baby rabbits.
messages: Intestine.
messages: Repeat 2 contains the catalytic domain.
messages: Undergoes proteolytic cleavage in the ileum.

9986:LOC100343304
gene id: 9986:LOC100343304
uniprot id: G1T7J3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100352398
gene id: 9986:LOC100352398
uniprot id: G1SY77
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

9986:LOC103352023
gene id: 9986:LOC103352023
uniprot id: G1U1Z2
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9986:LOC100356216
gene id: 9986:LOC100356216
uniprot id: G1SMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9986:SYPL2
gene id: 9986:SYPL2
uniprot id: O62646
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.
messages: Membrane
messages: Skeletal muscle.

9986:ORYCUNV1R1640
gene id: 9986:ORYCUNV1R1640
uniprot id: A0A5F9DD80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CYRIB
gene id: 9986:CYRIB
uniprot id: G1T5Y2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9986:LOC100354336
gene id: 9986:LOC100354336
uniprot id: A0A5F9C8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341910
gene id: 9986:LOC100341910
uniprot id: A0A7R8GV23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100358539
gene id: 9986:LOC100358539
uniprot id: G1TDB6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9986:LOC100354470
gene id: 9986:LOC100354470
uniprot id: A0A5F9CSP6
uniprot id: G1SKP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100345777
gene id: 9986:LOC100345777
uniprot id: A0A5F9D7T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9986:LOC100357405
gene id: 9986:LOC100357405
uniprot id: G1SQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9986:SEC16B
gene id: 9986:SEC16B
uniprot id: Q6BCB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Liver.
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with TFG. Interacts with SEC13.

9986:LOC100339299
gene id: 9986:LOC100339299
uniprot id: G1TA66
names: Similarity
messages: Belongs to the CARF family.

9986:LOC100353935
gene id: 9986:LOC100353935
uniprot id: G1SKZ4
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9986:LOC100352679
gene id: 9986:LOC100352679
uniprot id: G1SJX9
names: Similarity
messages: Belongs to the CLCR family.

9986:LOC100345180
gene id: 9986:LOC100345180
uniprot id: G1T5N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9986:SLC17A5
gene id: 9986:SLC17A5
uniprot id: B7NZC4
uniprot id: U3KMC3
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346169
gene id: 9986:LOC100346169
uniprot id: G1TUC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9986:LOC100354012
gene id: 9986:LOC100354012
uniprot id: G1TVJ2
names: Similarity
messages: Belongs to the RELT family.

9986:LOC100344093
gene id: 9986:LOC100344093
uniprot id: A0A5F9DKU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9986:LOC100348541
gene id: 9986:LOC100348541
uniprot id: G1T977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9986:LOC100356656
gene id: 9986:LOC100356656
uniprot id: A0A5F9CEP6
uniprot id: A0A5F9CIB0
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9986:LOC103351898
gene id: 9986:LOC103351898
uniprot id: G1TLV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352103
gene id: 9986:LOC100352103
uniprot id: G1SDU2
names: Similarity
messages: Belongs to the taxilin family.

9986:LOC100353448
gene id: 9986:LOC100353448
uniprot id: G1T0N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

9986:LOC100346957
gene id: 9986:LOC100346957
uniprot id: G1TVQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9986:LOC100347157
gene id: 9986:LOC100347157
uniprot id: G1T6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9986:LOC100009040
gene id: 9986:LOC100009040
uniprot id: G1T0K2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100355846
gene id: 9986:LOC100355846
uniprot id: G1SEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100343313
gene id: 9986:LOC100343313
uniprot id: G1T7F9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9986:LOC100350738
gene id: 9986:LOC100350738
uniprot id: G1T1E6
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9986:LOC100352765
gene id: 9986:LOC100352765
uniprot id: G1SW69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9986:EIF2D
gene id: 9986:EIF2D
uniprot id: P0CL18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9986:LOC100339517
gene id: 9986:LOC100339517
uniprot id: G1SLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9986:LOC100340497
gene id: 9986:LOC100340497
uniprot id: G1SW14
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100353417
gene id: 9986:LOC100353417
uniprot id: G1T6N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

9986:LOC100358341
gene id: 9986:LOC100358341
uniprot id: G1TRK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100337730
gene id: 9986:LOC100337730
uniprot id: A0A5F9CX56
uniprot id: G1T4C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9986:LOC100303772
gene id: 9986:LOC100303772
uniprot id: G1SXS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9986:LOC100341356
gene id: 9986:LOC100341356
uniprot id: G1TEU7
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9986:LOC100355055
gene id: 9986:LOC100355055
uniprot id: G1SE75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9986:LOC103351148
gene id: 9986:LOC103351148
uniprot id: G1TXU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100009554
gene id: 9986:LOC100009554
uniprot id: G1SZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9986:KCNA2
gene id: 9986:KCNA2
uniprot id: Q09081
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Detected in portal vein myocytes (at protein level) (PubMed:11717160). Detected in portal vein (PubMed:11717160). Brain, liver and kidney.
messages: Endoplasmic reticulum membrane
messages: Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNA1, KCNA4, KCNA5, KCNA6 and KCNA7. Channel activity is regulated by interaction with the beta subunits, including KCNAB1 and KCNAB2. Identified in a complex with KCNA1 and KCNAB2 (By similarity). Identified in a complex with KCNA4 and FYN (PubMed:11149959). Identified in a complex with KCNA5 and KCNAB1 (PubMed:11717160). Interacts with the beta subunit KCNAB1 (PubMed:11717160,). Interacts with PTK2B (By similarity). Interacts (via C-terminus) with CTTN (By similarity). Interacts (via N-terminal cytoplasmic domain) with RHOA (GTP-bound form); this regulates channel activity by reducing location at the cell surface in response to CHRM1 activation (By similarity). Interacts with DRD2 (By similarity). Interacts with SIGMAR1; cocaine consumption leads to increased interaction (By similarity). Interacts with ADAM22 (By similarity). Interacts with CNTNAP2 (By similarity). Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with ADAM11 (By similarity).
messages: Inhibited by 4-aminopyridine (4-AP) (PubMed:11717161). Inhibited by dendrotoxin (DTX) and charybdotoxin (CTX), but not by tetraethylammonium (TEA) (By similarity). Inhibited by tityustoxin-K alpha (TsTX-Kalpha), a toxin that is highly specific for KCNA2 (By similarity). Inhibited by maurotoxin (By similarity). Inhibited by kappaM conotoxins kappaM-RIIIJ and kappaM-RIIIK (By similarity).
messages: Membrane
messages: N-glycosylated, with complex, sialylated N-glycans.
messages: Phosphorylated on tyrosine residues; phosphorylation increases in response to ischemia (By similarity). Phosphorylated on tyrosine residues by activated PTK2B/PYK2 (By similarity). Phosphorylation on tyrosine residues suppresses ion channel activity (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation; this abolishes interaction with CTTN. This is probably due to endocytosis of the phosphorylated channel subunits (By similarity). Phosphorylated on serine residues in response to increased cAMP levels; phosphorylation is apparently not catalyzed by PKA (By similarity).
messages: Presynaptic cell membrane
messages: Synapse
messages: The cytoplasmic N-terminus is important for tetramerization. Interactions between the different subunits modulate the gating characteristics (By similarity). Besides, the cytoplasmic N-terminal domain mediates interaction with RHOA and thus is required for RHOA-mediated endocytosis (By similarity).
messages: The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP).
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11717161). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:11717161). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:11717161, PubMed:19389710). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (By similarity). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random…
messages: axon
messages: dendrite
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9986:LOC100349028
gene id: 9986:LOC100349028
uniprot id: G1SNV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9986:LOC100101568
gene id: 9986:LOC100101568
uniprot id: G1TVA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9986:LOC100351624
gene id: 9986:LOC100351624
uniprot id: G1SQ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9986:LOC100354004
gene id: 9986:LOC100354004
uniprot id: A0A5F9DQV9
uniprot id: G1T2A3
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9986:OR51F1
gene id: 9986:OR51F1
uniprot id: B8K144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343972
gene id: 9986:LOC100343972
uniprot id: G1T6I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9986:LOC100355791
gene id: 9986:LOC100355791
uniprot id: G1T8G6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354206
gene id: 9986:LOC100354206
uniprot id: G1SPD5
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100346964
gene id: 9986:LOC100346964
uniprot id: G1T0J8
names: Similarity
messages: Belongs to the peptidase C14A family.

9986:LOC100348514
gene id: 9986:LOC100348514
uniprot id: G1U264
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9986:FMO3
gene id: 9986:FMO3
uniprot id: P32417
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Liver.
messages: Microsome membrane

9986:LOC100347807
gene id: 9986:LOC100347807
uniprot id: G1U744
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100358239
gene id: 9986:LOC100358239
uniprot id: G1TM95
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9986:LOC100340119
gene id: 9986:LOC100340119
uniprot id: G1T966
names: Similarity
messages: Belongs to the DDI1 family.

9986:LOC100350079
gene id: 9986:LOC100350079
uniprot id: G1T1P8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9986:LOC100356707
gene id: 9986:LOC100356707
uniprot id: G1SV27
names: Similarity
messages: Belongs to the OSBP family.

9986:LOC100359224
gene id: 9986:LOC100359224
uniprot id: G1SD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9986:LOC100338251
gene id: 9986:LOC100338251
uniprot id: A0A5F9D6R0
names: Similarity
messages: Belongs to the SLITRK family.

9986:LOC100353340
gene id: 9986:LOC100353340
uniprot id: G1SGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Cytoplasm

9986:LOC100339542
gene id: 9986:LOC100339542
uniprot id: G1T8X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352776
gene id: 9986:LOC100352776
uniprot id: G1TV97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9986:LOC100344144
gene id: 9986:LOC100344144
uniprot id: G1T3Z0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9986:LOC100352161
gene id: 9986:LOC100352161
uniprot id: A0A5F9DND0
uniprot id: G1SUG7
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9986:LOC100354006
gene id: 9986:LOC100354006
uniprot id: G1SXJ0
names: Similarity
messages: Belongs to the FAM114 family.

9986:LOC100343673
gene id: 9986:LOC100343673
uniprot id: G1U8C4
names: Similarity
messages: Belongs to the PA28 family.

9986:LOC100008646
gene id: 9986:LOC100008646
uniprot id: G1SVZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9986:LOC100349007
gene id: 9986:LOC100349007
uniprot id: A0A5F9CIX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9986:LOC100345242
gene id: 9986:LOC100345242
uniprot id: G1SQI8
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9986:LOC100008919
gene id: 9986:LOC100008919
uniprot id: G1SZP6
names: Similarity
messages: Belongs to the heme oxygenase family.

9986:LOC100343213
gene id: 9986:LOC100343213
uniprot id: G1TAF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ependymin family.
messages: Binds anionic lipids and gangliosides at acidic pH.
messages: Lysosome lumen

9986:LOC100350679
gene id: 9986:LOC100350679
uniprot id: G1TD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

9986:LOC100349671
gene id: 9986:LOC100349671
uniprot id: A0A5F9CH00
uniprot id: G1T3B8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100351131
gene id: 9986:LOC100351131
uniprot id: G1SHI4
names: Similarity
messages: Belongs to the MS4A family.

9986:LOC100338719
gene id: 9986:LOC100338719
uniprot id: G1U8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9986:LOC100352597
gene id: 9986:LOC100352597
uniprot id: G1SEP9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9986:LOC100008924
gene id: 9986:LOC100008924
uniprot id: G1SWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9986:LOC103348521
gene id: 9986:LOC103348521
uniprot id: U3KNK8
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9986:LOC100344243
gene id: 9986:LOC100344243
uniprot id: G1SPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100340323
gene id: 9986:LOC100340323
uniprot id: G1SLN7
names: Similarity
messages: Belongs to the arrestin family.

9986:LOC100349066
gene id: 9986:LOC100349066
uniprot id: A0A5F9C8P6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.
messages: Secreted

9986:LOC100352489
gene id: 9986:LOC100352489
uniprot id: G1T6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9986:LOC100356586
gene id: 9986:LOC100356586
uniprot id: G1SWZ8
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339248
gene id: 9986:LOC100339248
uniprot id: A0A5F9DLD6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9986:LOC100348907
gene id: 9986:LOC100348907
uniprot id: G1T0M5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9986:LOC100350872
gene id: 9986:LOC100350872
uniprot id: G1TGB5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9986:LOC100355853
gene id: 9986:LOC100355853
uniprot id: G1TCQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9986:LOC100356229
gene id: 9986:LOC100356229
uniprot id: G1SRX3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9986:LOC100358436
gene id: 9986:LOC100358436
uniprot id: G1SHH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9986:LOC100347583
gene id: 9986:LOC100347583
uniprot id: G1U1K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9986:LOC100345774
gene id: 9986:LOC100345774
uniprot id: G1TN62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9986:LOC100352256
gene id: 9986:LOC100352256
uniprot id: G1STW2
names: Similarity
messages: Belongs to the peptidase M1 family.

9986:GPX1
gene id: 9986:GPX1
uniprot id: P11909
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: During periods of oxidative stress, Sec-46 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.
messages: Homotetramer. Interacts with MIEN1 (By similarity).
messages: Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.

9986:PDIA3
gene id: 9986:PDIA3
uniprot id: B7NZF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9986:SERPINB10
gene id: 9986:SERPINB10
uniprot id: B7NZA0
uniprot id: G1STT3
names: Similarity
messages: Belongs to the serpin family.

9986:LOC100351895
gene id: 9986:LOC100351895
uniprot id: G1U251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9986:LOC100359192
gene id: 9986:LOC100359192
uniprot id: G1U4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC103348184
gene id: 9986:LOC103348184
uniprot id: A0A5F9CCA2
uniprot id: G1SPR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9986:LOC100349381
gene id: 9986:LOC100349381
uniprot id: G1TBI9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100345086
gene id: 9986:LOC100345086
uniprot id: G1SYT0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100355431
gene id: 9986:LOC100355431
uniprot id: G1STF6
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340884
gene id: 9986:LOC100340884
uniprot id: A0A5F9CAQ7
uniprot id: A0A5F9CH77
uniprot id: A0A5F9CSC1
uniprot id: A0A5F9CVD9
uniprot id: A0A5F9DSX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9986:LOC100357499
gene id: 9986:LOC100357499
uniprot id: G1T301
names: Similarity
messages: Belongs to the AKAP95 family.

9986:LOC100354333
gene id: 9986:LOC100354333
uniprot id: A0A5F9D995
names: Similarity
messages: Belongs to the zygin family.

9986:LOC100351728
gene id: 9986:LOC100351728
uniprot id: G1TCV9
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9986:LOC100354727
gene id: 9986:LOC100354727
uniprot id: P81436
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue (PubMed:2137449). Acts on cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, ATG4B, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcri…
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Homotrimer, oligomerizes via TPR repeats 6 and 7. Trimerization is not necessary for activity in vitro, however it increases affinity for UDP-GlcNAc (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts (via TPR 5-6) with TET1, TET2 and TET3 (By similarity). Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Interacts with histone H2B (By similarity). Interacts with BMAL1. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity). Component of a complex composed of KMT2E/MLL5, OGT and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteosomal-mediated degradation. Interacts (via TRP repeats) with KMT2E/MLL5 (via N-terminus). Interacts with USP7. Interacts with TRAK1; this interaction is not required for glycosylation of TRAK1 by this protein. Found in a complex with KIF5B, RHOT1, RHOT2 and TRAK1 (By similarity). Interacts (via TPR repeats domain) with HOXA1; the interaction takes place mainly in the nucleus (By similarity). Interacts with NSD2 (By similarity).
messages: Inhibited by UDP.
messages: Mitochondrion membrane
messages: Nucleus
messages: Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity.
messages: The TPR repeat domain is required for substrate binding and oligomerization.
messages: Ubiquitinated, leading to its proteasomal degradation.

9986:LOC100358543
gene id: 9986:LOC100358543
uniprot id: G1T6Z8
names: Similarity
messages: Belongs to the FGGY kinase family.

9986:CALCR
gene id: 9986:CALCR
uniprot id: G1TV01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9986:PAXBP1
gene id: 9986:PAXBP1
uniprot id: B8K1B3
names: Similarity
messages: Belongs to the GCF family.

9986:LOC100346176
gene id: 9986:LOC100346176
uniprot id: A0A5F9D7C2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:LOC100350892
gene id: 9986:LOC100350892
uniprot id: G1U6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9986:LOC100348732
gene id: 9986:LOC100348732
uniprot id: P12345
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
messages: Cell membrane
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

9986:LOC100339764
gene id: 9986:LOC100339764
uniprot id: G1T9H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

9986:LOC100344642
gene id: 9986:LOC100344642
uniprot id: G1T1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9986:LOC100354580
gene id: 9986:LOC100354580
uniprot id: G1TIS3
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9986:LOC100354979
gene id: 9986:LOC100354979
uniprot id: G1TSN4
uniprot id: G1TYC7
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9986:LOC100344660
gene id: 9986:LOC100344660
uniprot id: G1U2Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100352864
gene id: 9986:LOC100352864
uniprot id: G1SIE1
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100348534
gene id: 9986:LOC100348534
uniprot id: G1TVN6
names: Similarity
messages: Belongs to the TTC39 family.

9986:LOC100341244
gene id: 9986:LOC100341244
uniprot id: G1T213
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9986:LOC100356648
gene id: 9986:LOC100356648
uniprot id: G1T2T1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9986:LOC100340682
gene id: 9986:LOC100340682
uniprot id: G1SR83
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350305
gene id: 9986:LOC100350305
uniprot id: G1SNT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9986:LOC100352336
gene id: 9986:LOC100352336
uniprot id: G1SNJ7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9986:LOC100347529
gene id: 9986:LOC100347529
uniprot id: G1T505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100350169
gene id: 9986:LOC100350169
uniprot id: G1T952
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9986:LOC100338320
gene id: 9986:LOC100338320
uniprot id: G1TY23
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9986:LOC100355634
gene id: 9986:LOC100355634
uniprot id: G1T4G0
names: Similarity
messages: Belongs to the DOCK family.

9986:LOC100350557
gene id: 9986:LOC100350557
uniprot id: G1SFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9986:LOC100347150
gene id: 9986:LOC100347150
uniprot id: G1SSZ6
names: Similarity
messages: Belongs to the TCP10 family.

9986:ZPR1
gene id: 9986:ZPR1
uniprot id: B7NZL8
names: Similarity
messages: Belongs to the ZPR1 family.

9986:LOC100352530
gene id: 9986:LOC100352530
uniprot id: G1SQ11
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9986:LOC100355375
gene id: 9986:LOC100355375
uniprot id: A0A5K1UI97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9986:LOC100340902
gene id: 9986:LOC100340902
uniprot id: G1TMV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9986:LOC100347119
gene id: 9986:LOC100347119
uniprot id: G1TI21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CIAO2A
gene id: 9986:CIAO2A
uniprot id: G1SXG7
names: Similarity
messages: Belongs to the MIP18 family.

9986:LOC100342825
gene id: 9986:LOC100342825
uniprot id: G1TKQ8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9986:LOC100352253
gene id: 9986:LOC100352253
uniprot id: G1SY09
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346868
gene id: 9986:LOC100346868
uniprot id: A0A5F9C9S1
uniprot id: G1SLU3
uniprot id: U3KNU3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9986:LOC100356800
gene id: 9986:LOC100356800
uniprot id: G1TQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356898
gene id: 9986:LOC100356898
uniprot id: G1TCJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9986:LOC100357244
gene id: 9986:LOC100357244
uniprot id: G1SEX7
names: Subcellular Location Annotation
messages: Membrane

9986:HOXD13
gene id: 9986:HOXD13
uniprot id: U3KM50
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100339653
gene id: 9986:LOC100339653
uniprot id: G1T5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9986:LOC100352585
gene id: 9986:LOC100352585
uniprot id: A0A5F9C5R0
uniprot id: A0A5F9CKF9
uniprot id: G1T533
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9986:LOC100351745
gene id: 9986:LOC100351745
uniprot id: G1TQC3
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9986:LOC100356391
gene id: 9986:LOC100356391
uniprot id: G1SX21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9986:LOC100358791
gene id: 9986:LOC100358791
uniprot id: A0A5F9DSU8
uniprot id: G1SDH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9986:LOC100341025
gene id: 9986:LOC100341025
uniprot id: G1T9D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100355227
gene id: 9986:LOC100355227
uniprot id: G1SUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:LOC100343637
gene id: 9986:LOC100343637
uniprot id: G1SV29
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9986:LOC100345574
gene id: 9986:LOC100345574
uniprot id: G1T5J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9986:WAP
gene id: 9986:WAP
uniprot id: P09412
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Could be a protease inhibitor.
messages: Milk-specific; major protein component of milk whey.
messages: Secreted

9986:SLC4A4
gene id: 9986:SLC4A4
uniprot id: A0A5F9DW44
uniprot id: Q9XSZ4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
messages: Expressed in colonic mucosa, kidney cortex and to gastric mucosa.
messages: Homodimer. Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity. Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity. Interacts with AHCYL2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-glycosylated. May not be necessary for the transporter basic functions.
messages: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity.

9986:LOC100350168
gene id: 9986:LOC100350168
uniprot id: A0A5F9DUW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9986:LOC100346959
gene id: 9986:LOC100346959
uniprot id: G1SWC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9986:LOC100351510
gene id: 9986:LOC100351510
uniprot id: G1SGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339172
gene id: 9986:LOC100339172
uniprot id: G1T8T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

9986:LOC100344146
gene id: 9986:LOC100344146
uniprot id: G1SHM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9986:MELTF
gene id: 9986:MELTF
uniprot id: O97490
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferrin family.
messages: Cell membrane
messages: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc (By similarity).

9986:LOC100352749
gene id: 9986:LOC100352749
uniprot id: G1SW64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9986:LOC100345750
gene id: 9986:LOC100345750
uniprot id: G1SY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9986:ELAPOR2
gene id: 9986:ELAPOR2
uniprot id: G1SSW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9986:LOC100355609
gene id: 9986:LOC100355609
uniprot id: G1U2K9
names: Similarity
messages: Belongs to the cyclin family.

9986:LOC100347413
gene id: 9986:LOC100347413
uniprot id: G1SQ06
names: Similarity
messages: Belongs to the MMACHC family.

9986:LOC100342648
gene id: 9986:LOC100342648
uniprot id: A0A5F9CIV3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9986:LOC100347677
gene id: 9986:LOC100347677
uniprot id: G1SSI7
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

9986:LOC100352068
gene id: 9986:LOC100352068
uniprot id: G1SWF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9986:LOC100348482
gene id: 9986:LOC100348482
uniprot id: G1U1Y6
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100345227
gene id: 9986:LOC100345227
uniprot id: G1U228
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:LOC103351685
gene id: 9986:LOC103351685
uniprot id: G1TDT1
names: Similarity
messages: Belongs to the lin-52 family.

9986:LOC100344226
gene id: 9986:LOC100344226
uniprot id: A0A5F9DRL2
names: Similarity
messages: Belongs to the pro/parathymosin family.

9986:LOC100339323
gene id: 9986:LOC100339323
uniprot id: G1SMQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9986:LOC100357309
gene id: 9986:LOC100357309
uniprot id: G1SMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9986:LOC100352681
gene id: 9986:LOC100352681
uniprot id: G1TGZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100345739
gene id: 9986:LOC100345739
uniprot id: A0A5F9DB26
uniprot id: G1T7U6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LASP1
gene id: 9986:LASP1
uniprot id: O77506
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with F-actin (By similarity). Interacts with ANKRD54. Interacts with KBTBD10 (By similarity).
messages: Phosphorylated on serine residues after stimulation with histamine.
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
messages: Widely expressed with highest levels in mucosal tissues throughout the gastrointestinal tract as well as in heart, lung, liver, kidney, adrenal and smooth muscle. Lowest level is observed in skeletal muscle.
messages: cell cortex
messages: cytoskeleton

9986:LOC100009355
gene id: 9986:LOC100009355
uniprot id: G1T2M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9986:TLR5
gene id: 9986:TLR5
uniprot id: K7NB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9986:LOC100356131
gene id: 9986:LOC100356131
uniprot id: G1SIY1
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9986:SLC9A1
gene id: 9986:SLC9A1
uniprot id: P23791
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Kidney and intestine.
messages: Membrane
messages: O-glycosylated.
messages: Oligomer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity). Interacts with TESC (By similarity). Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner (By similarity). Interacts with CHP2; the interaction occurs in a calcium-dependent manner (By similarity).
messages: The interacting region with TESC is conflicting: In human, it has been reported that SLC9A1 interacts with TESC via the juxtamembrane region of the cytoplasmic C-terminal domain, including residues 503-545. However, another publication has reported interaction with TESC via residues 633-816, the region of the cytoplasmic C-terminus more distal to the membrane.
messages: The region between transmembrane regions M4 and M5 and between M6 and M7 (also termed intracellular loops IL2 and IL4, respectively) seem to be localized at least in part in the membrane. The hydrophobic region H10 is proposed to be located within the membrane.
messages: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).

9986:LOC100008761
gene id: 9986:LOC100008761
uniprot id: P57999
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling (By similarity).
messages: Cell membrane
messages: During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
messages: Probably forms covalent oligomers.
messages: The MAM domains probably mediate sperm adhesion to the zona pellucida.
messages: The VWFD domains 2 and 3 may mediate covalent oligomerization (By similarity to human intestinal mucin MUC2).

9986:LOC100357577
gene id: 9986:LOC100357577
uniprot id: G1TDX4
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9986:LOC100351641
gene id: 9986:LOC100351641
uniprot id: G1T2C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9986:LOC103350153
gene id: 9986:LOC103350153
uniprot id: G1TUD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

9986:LOC100144331
gene id: 9986:LOC100144331
uniprot id: G1TD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9986:LOC100348145
gene id: 9986:LOC100348145
uniprot id: G1SY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9986:LOC100358512
gene id: 9986:LOC100358512
uniprot id: G1TL06
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9986:LOC100358340
gene id: 9986:LOC100358340
uniprot id: G1T1K4
names: Similarity
messages: Belongs to the LIMR family.

9986:ATOSB
gene id: 9986:ATOSB
uniprot id: G1SR18
names: Similarity
messages: Belongs to the FAM214 family.

9986:TRDN
gene id: 9986:TRDN
uniprot id: Q28820
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction (PubMed:19398037, PubMed:17846166 and PubMed:7721813). Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity).
messages: Detected in skeletal muscle and in heart (at protein level). Detected in skeletal muscle and in heart.
messages: Interacts with CASQ2 (By similarity). Homooligomer of variable subunit number; disulfide-linked. Interacts with CASQ1 and RYR1 in skeletal muscle.
messages: N-glycosylated.
messages: Phosphorylated by CaMK2.
messages: Sarcoplasmic reticulum membrane

9986:LOC100344917
gene id: 9986:LOC100344917
uniprot id: G1TTC3
names: Similarity
messages: Belongs to the TGF-beta family.

9986:LOC100353112
gene id: 9986:LOC100353112
uniprot id: G1TBA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9986:LOC100354681
gene id: 9986:LOC100354681
uniprot id: G1SFS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9986:LOC108176483
gene id: 9986:LOC108176483
uniprot id: G1TZ57
names: Similarity
messages: Belongs to the SAP30 family.

9986:SYN3
gene id: 9986:SYN3
uniprot id: B7NZN5
names: Similarity
messages: Belongs to the synapsin family.

9986:CFAP97D1
gene id: 9986:CFAP97D1
uniprot id: G1TAT8
names: Similarity
messages: Belongs to the CFAP97 family.

9986:LOC100354804
gene id: 9986:LOC100354804
uniprot id: G1TET1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9986:LOC100351783
gene id: 9986:LOC100351783
uniprot id: G1SHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9986:LOC100352954
gene id: 9986:LOC100352954
uniprot id: G1T7V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

9986:LOC100352888
gene id: 9986:LOC100352888
uniprot id: A0A5F9CHF8
uniprot id: A0A5F9CT57
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100358172
gene id: 9986:LOC100358172
uniprot id: G1TBJ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100354361
gene id: 9986:LOC100354361
uniprot id: G1SZF5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100341506
gene id: 9986:LOC100341506
uniprot id: G1T745
names: Similarity
messages: Belongs to the TMEM131 family.

9986:LOC100008965
gene id: 9986:LOC100008965
uniprot id: A0A5F9DQD8
uniprot id: G1SYB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9986:LOC100359149
gene id: 9986:LOC100359149
uniprot id: G1U2Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

9986:LOC100342991
gene id: 9986:LOC100342991
uniprot id: A0A5F9DRU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

9986:PPARD
gene id: 9986:PPARD
uniprot id: Q9N2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:STEAP2
gene id: 9986:STEAP2
uniprot id: B6A7P9
uniprot id: G1T875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9986:LOC100348824
gene id: 9986:LOC100348824
uniprot id: A0A5F9DAT5
uniprot id: G1SG26
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100345523
gene id: 9986:LOC100345523
uniprot id: A0A5F9CI23
uniprot id: A0A5F9DSK2
uniprot id: G1TE11
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346442
gene id: 9986:LOC100346442
uniprot id: G1SH53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9986:LOC100348067
gene id: 9986:LOC100348067
uniprot id: A0A5F9CEM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9986:LOC100343128
gene id: 9986:LOC100343128
uniprot id: A0A5F9CG93
names: Subcellular Location Annotation
messages: Nucleus

9986:OLR60
gene id: 9986:OLR60
uniprot id: B8K139
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353178
gene id: 9986:LOC100353178
uniprot id: G1TQ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9986:LOC100343152
gene id: 9986:LOC100343152
uniprot id: A0A5F9C1S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9986:LOC100359168
gene id: 9986:LOC100359168
uniprot id: G1TKQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9986:LOC100352594
gene id: 9986:LOC100352594
uniprot id: G1SQL4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9986:LOC100345738
gene id: 9986:LOC100345738
uniprot id: G1SWE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9986:LOC100009490
gene id: 9986:LOC100009490
uniprot id: G1SCG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9986:LOC100354585
gene id: 9986:LOC100354585
uniprot id: G1TNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340636
gene id: 9986:LOC100340636
uniprot id: A0A5F9CBQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9986:LOC100348996
gene id: 9986:LOC100348996
uniprot id: G1SFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9986:LOC100340654
gene id: 9986:LOC100340654
uniprot id: A0A5F9D1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane
messages: Mitochondrion outer membrane

9986:LOC100345360
gene id: 9986:LOC100345360
uniprot id: G1SMU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9986:MDFIC
gene id: 9986:MDFIC
uniprot id: B7NZU8
names: Similarity
messages: Belongs to the MDFI family.

9986:LOC100346346
gene id: 9986:LOC100346346
uniprot id: G1U911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357378
gene id: 9986:LOC100357378
uniprot id: G1SXF1
names: Similarity
messages: Belongs to the NifU family.

9986:LOC100358835
gene id: 9986:LOC100358835
uniprot id: G1SN34
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9986:LOC100357245
gene id: 9986:LOC100357245
uniprot id: G1SHQ0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9986:LOC100343475
gene id: 9986:LOC100343475
uniprot id: G1STD9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9986:LOC100343029
gene id: 9986:LOC100343029
uniprot id: G1SHV6
names: Similarity
messages: Belongs to the CFAP97 family.

9986:LOC100354976
gene id: 9986:LOC100354976
uniprot id: A0A5F9D010
uniprot id: G1T853
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9986:LOC100355544
gene id: 9986:LOC100355544
uniprot id: G1TQF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9986:LOC100341262
gene id: 9986:LOC100341262
uniprot id: G1SUB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9986:LOC100356532
gene id: 9986:LOC100356532
uniprot id: G1SFZ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9986:LOC100350272
gene id: 9986:LOC100350272
uniprot id: G1TDA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100341961
gene id: 9986:LOC100341961
uniprot id: G1T543
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:CSN1S1
gene id: 9986:CSN1S1
uniprot id: P09115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9986:LOC100342869
gene id: 9986:LOC100342869
uniprot id: G1STD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9986:CCN1
gene id: 9986:CCN1
uniprot id: G1SKP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:NT5C3A
gene id: 9986:NT5C3A
uniprot id: A1BN59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9986:LOC100340025
gene id: 9986:LOC100340025
uniprot id: G1SFA4
names: Similarity
messages: Belongs to the BRINP family.

9986:LOC100344987
gene id: 9986:LOC100344987
uniprot id: G1TE96
names: Similarity
messages: Belongs to the LanC-like protein family.

9986:LOC100341987
gene id: 9986:LOC100341987
uniprot id: A0A5F9C0V1
uniprot id: A0A5F9D340
uniprot id: A0A5F9D6N5
uniprot id: A0A5F9DMR9
uniprot id: G1SYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9986:LOC100352792
gene id: 9986:LOC100352792
uniprot id: G1TXB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9986:LOC100347886
gene id: 9986:LOC100347886
uniprot id: G1T0T6
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9986:LOC100357645
gene id: 9986:LOC100357645
uniprot id: G1SUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9986:LOC100355850
gene id: 9986:LOC100355850
uniprot id: G1TKD5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9986:DKK1
gene id: 9986:DKK1
uniprot id: Q6PVU5
names: Similarity
messages: Belongs to the dickkopf family.

9986:LOC100355349
gene id: 9986:LOC100355349
uniprot id: G1SQU6
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9986:LOC100348981
gene id: 9986:LOC100348981
uniprot id: G1SS70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9986:LOC100351767
gene id: 9986:LOC100351767
uniprot id: G1SP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9986:LOC100357061
gene id: 9986:LOC100357061
uniprot id: G1SWR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9986:LOC108178657
gene id: 9986:LOC108178657
uniprot id: G1SY27
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9986:NAT2
gene id: 9986:NAT2
uniprot id: P11246
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arylamine N-acetyltransferase family.
messages: Cytoplasm
messages: The N-terminus is blocked.

9986:LOC100348386
gene id: 9986:LOC100348386
uniprot id: G1TI52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9986:LOC100341357
gene id: 9986:LOC100341357
uniprot id: G1SSF5
uniprot id: U3KPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9986:LOC100351691
gene id: 9986:LOC100351691
uniprot id: G1STV6
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9986:SERPIND1
gene id: 9986:SERPIND1
uniprot id: P47776
names: Domain
names: Function
names: PTM
names: Similarity
messages: Belongs to the serpin family.
messages: N-glycosylated; different glycan composition appears to lead to two forms of this protein (56 and 60 kDa).
messages: The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
messages: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT).

9986:LOC108178113
gene id: 9986:LOC108178113
uniprot id: G1U6B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9986:LOC100359228
gene id: 9986:LOC100359228
uniprot id: A0A5F9CUS3
uniprot id: A0A5F9D2M0
uniprot id: A0A5F9D4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9986:LOC100353660
gene id: 9986:LOC100353660
uniprot id: G1TYK4
names: Similarity
messages: Belongs to the histone H3 family.

9986:LOC100008896
gene id: 9986:LOC100008896
uniprot id: A0A5F9DMA9
uniprot id: G1SQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9986:LOC100357042
gene id: 9986:LOC100357042
uniprot id: A0A5F9C2P2
uniprot id: A0A5F9CLV0
names: Similarity
messages: Belongs to the EVA1 family.

9986:LOC100342715
gene id: 9986:LOC100342715
uniprot id: G1T5P7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100353927
gene id: 9986:LOC100353927
uniprot id: G1T2A7
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9986:LOC100342742
gene id: 9986:LOC100342742
uniprot id: G1STC1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:LOC100343726
gene id: 9986:LOC100343726
uniprot id: G1T184
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9986:LOC100357329
gene id: 9986:LOC100357329
uniprot id: G1U0B4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9986:LOC100342450
gene id: 9986:LOC100342450
uniprot id: G1TCV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

9986:LOC100348505
gene id: 9986:LOC100348505
uniprot id: G1SSM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100348644
gene id: 9986:LOC100348644
uniprot id: G1SS17
names: Similarity
messages: Belongs to the Tdpoz family.

9986:HGF
gene id: 9986:HGF
uniprot id: C9E9X4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9986:CLU
gene id: 9986:CLU
uniprot id: Q9XSC5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 and PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1. Interacts (immaturely glycosylated pre-secreted form) with HSPA5; this interaction promotes CLU stability and facilitates stress-induced CLU retrotranslocation from the secretory pathway to the mitochondria, thereby reducing stress-induced apoptosis by stabilizing mitochondrial membrane integrity. Interacts with BCL2L1; this interaction releases and activates BAX and promotes cell death. Interacts with TGFBR2 and ACVR1 (By similarity). Interacts (secreted form) with STMN3; this interaction may act as an important modulator during neuronal differentiation (By similarity). Interacts with VLDLR and LRP8 (By similarity).
messages: Belongs to the clusterin family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).
messages: Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate. Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms. Core carbohydrates are essential for chaperone activity. Non-secreted forms are hypoglycosylated or unglycosylated.
messages: Microsome
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation. Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation.
messages: Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen. Proteolytic cleavage is not necessary for its chaperone activity. All non-secreted forms are not proteolytically cleaved. Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment.
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9986:COX6A1
gene id: 9986:COX6A1
uniprot id: Q9TTT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9986:LOC100356745
gene id: 9986:LOC100356745
uniprot id: G1SZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9986:LOC100338639
gene id: 9986:LOC100338639
uniprot id: G1T7I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9986:LOC100342940
gene id: 9986:LOC100342940
uniprot id: G1T2E9
names: Similarity
messages: Belongs to the PROTOR family.

9986:OLFR645
gene id: 9986:OLFR645
uniprot id: B8K194
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343408
gene id: 9986:LOC100343408
uniprot id: G1T1K5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9986:LOC100356272
gene id: 9986:LOC100356272
uniprot id: G1SL32
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9986:AGO2
gene id: 9986:AGO2
uniprot id: O77503
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A phosphorylation cycle of C-terminal serine cluster (Ser-805-Ser-815) regulates the release of target mRNAs. Target-binding leads to phosphorylation of these residues by CSNK1A1, which reduces the affinity of AGO2 for mRNA and enables target release. The ANKRD52-PPP6C phosphatase complex dephosphorylates the residues, which primes AGO2 for binding a new target.
messages: Belongs to the argonaute family. Ago subfamily.
messages: Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.
messages: Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71; the interaction increases in presence of RNA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36. Interacts with RC3H1; the interaction is RNA independent (By similarity). Found in a complex composed of AGO2, CHD7 and FAM172A (By similarity). Interacts with SND1 and SYT11 (By similarity). Interacts with CLNK (By similarity). Interacts with GARRE1 (By similarity).
messages: Nucleus
messages: P-body
messages: Phosphorylation at Ser-368 by AKT3; leads to up-regulate translational repression of microRNA target and down-regulate endonucleolytic cleavage.
messages: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
messages: The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).
messages: Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO2 when it is engaged with a TDMD target.

9986:LOC100343660
gene id: 9986:LOC100343660
uniprot id: G1T6Q9
names: Similarity
messages: Belongs to the syntaxin family.

9986:CASP10
gene id: 9986:CASP10
uniprot id: A5HAU9
names: Similarity
messages: Belongs to the peptidase C14A family.

9986:LOC100355809
gene id: 9986:LOC100355809
uniprot id: G1SG32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100351245
gene id: 9986:LOC100351245
uniprot id: G1T8T7
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9986:ANXA13
gene id: 9986:ANXA13
uniprot id: A0A5F9DQP5
uniprot id: Q8MJB5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9986:LOC100338047
gene id: 9986:LOC100338047
uniprot id: G1SXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9986:LOC100342463
gene id: 9986:LOC100342463
uniprot id: G1SG71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9986:LOC100347778
gene id: 9986:LOC100347778
uniprot id: G1SIM3
uniprot id: U3KP10
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9986:LOC100340643
gene id: 9986:LOC100340643
uniprot id: G1SHG0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9986:LOC100349847
gene id: 9986:LOC100349847
uniprot id: G1THI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:GOLM2
gene id: 9986:GOLM2
uniprot id: A0A5F9DA80
uniprot id: G1SNS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9986:LOC100008855
gene id: 9986:LOC100008855
uniprot id: A0A5F9CS92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

9986:LOC100344068
gene id: 9986:LOC100344068
uniprot id: G1TSL8
names: Subcellular Location Annotation
messages: Nucleus

9986:HNRNPC
gene id: 9986:HNRNPC
uniprot id: O77768
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM HNRPC family. RALY subfamily.
messages: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
messages: Nucleus
messages: Phosphorylated on Ser-260 and Ser-299 in resting cells.
messages: Sumoylated. Sumoylation reduces affinity for mRNA.
messages: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1 (By similarity). Interacts with PPIA/CYPA (By similarity).

9986:LOC100350176
gene id: 9986:LOC100350176
uniprot id: A0A5F9D7V9
uniprot id: G1T150
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9986:ABCC6
gene id: 9986:ABCC6
uniprot id: G1SYV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100341450
gene id: 9986:LOC100341450
uniprot id: G1T8L0
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9986:LOC100341351
gene id: 9986:LOC100341351
uniprot id: G1U312
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9986:LOC100351658
gene id: 9986:LOC100351658
uniprot id: A0A5F9C773
uniprot id: G1U7U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9986:LOC100347404
gene id: 9986:LOC100347404
uniprot id: G1TTY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9986:LOC100351853
gene id: 9986:LOC100351853
uniprot id: G1TAI0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9986:LOC100349423
gene id: 9986:LOC100349423
uniprot id: A0A0S4XRM6
uniprot id: G1SY87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100351808
gene id: 9986:LOC100351808
uniprot id: A0A5F9DVT1
names: Subcellular Location Annotation
messages: extracellular matrix

9986:CST3
gene id: 9986:CST3
uniprot id: O97862
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted
messages: This is a thiol proteinase inhibitor.

9986:LOC100350011
gene id: 9986:LOC100350011
uniprot id: G1U5G2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).

9986:NPSR1
gene id: 9986:NPSR1
uniprot id: G1SNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC100347426
gene id: 9986:LOC100347426
uniprot id: G1SHQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100357843
gene id: 9986:LOC100357843
uniprot id: G1TY30
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9986:LOC100350579
gene id: 9986:LOC100350579
uniprot id: G1SDR1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9986:LOC100351922
gene id: 9986:LOC100351922
uniprot id: G1SPW2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9986:LOC100344214
gene id: 9986:LOC100344214
uniprot id: A0A5F9CDI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9986:LOC100353066
gene id: 9986:LOC100353066
uniprot id: G1SG50
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9986:LOC100345174
gene id: 9986:LOC100345174
uniprot id: G1SS79
names: Similarity
messages: Belongs to the MARCKS family.

9986:LOC100338565
gene id: 9986:LOC100338565
uniprot id: G1T1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9986:LOC100357429
gene id: 9986:LOC100357429
uniprot id: G1SHP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:ADH2-2
gene id: 9986:ADH2-2
uniprot id: O46650
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

9986:LOC100357133
gene id: 9986:LOC100357133
uniprot id: G1SUL7
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9986:LOC100340245
gene id: 9986:LOC100340245
uniprot id: A0A5F9C225
uniprot id: A0A5F9CBU0
uniprot id: G1SWT1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100354619
gene id: 9986:LOC100354619
uniprot id: G1T2X6
names: Similarity
messages: Belongs to the paralemmin family.

9986:LOC103345024
gene id: 9986:LOC103345024
uniprot id: A0A5F9CH05
names: Similarity
messages: Belongs to the VPS25 family.

9986:PSME3IP1
gene id: 9986:PSME3IP1
uniprot id: G1SDK5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100344242
gene id: 9986:LOC100344242
uniprot id: A0A5F9CLC7
uniprot id: G1SDG0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9986:LOC100337956
gene id: 9986:LOC100337956
uniprot id: U3KPB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

9986:LOC100346716
gene id: 9986:LOC100346716
uniprot id: G1U155
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100355888
gene id: 9986:LOC100355888
uniprot id: G1T4S2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100347169
gene id: 9986:LOC100347169
uniprot id: G1TEH7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100346032
gene id: 9986:LOC100346032
uniprot id: G1SHF1
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9986:LOC100358446
gene id: 9986:LOC100358446
uniprot id: G1TCY8
names: Similarity
messages: Belongs to the WD repeat EBI family.

9986:LOC100339632
gene id: 9986:LOC100339632
uniprot id: G1SM00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100353552
gene id: 9986:LOC100353552
uniprot id: G1TXV6
names: Similarity
messages: Belongs to the peptidase C48 family.

9986:LOC100342264
gene id: 9986:LOC100342264
uniprot id: G1TD76
uniprot id: G1TG32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9986:LOC100341365
gene id: 9986:LOC100341365
uniprot id: G1SIZ2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9986:LOC100358354
gene id: 9986:LOC100358354
uniprot id: G1T721
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

9986:LOC100340975
gene id: 9986:LOC100340975
uniprot id: A0A5F9D933
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100349077
gene id: 9986:LOC100349077
uniprot id: G1SQ70
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Monomer.
messages: Secreted

9986:LOC100354367
gene id: 9986:LOC100354367
uniprot id: G1SG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9986:LOC100344304
gene id: 9986:LOC100344304
uniprot id: A0A5F9DR99
uniprot id: G1T1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9986:OLFR622
gene id: 9986:OLFR622
uniprot id: B8K172
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347587
gene id: 9986:LOC100347587
uniprot id: G1T3Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9986:LOC100349912
gene id: 9986:LOC100349912
uniprot id: G1T3Y8
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9986:LOC100346621
gene id: 9986:LOC100346621
uniprot id: A0A5F9C299
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:LOC100343638
gene id: 9986:LOC100343638
uniprot id: G1U2U2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9986:CORT
gene id: 9986:CORT
uniprot id: G1TTP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9986:LOC100352750
gene id: 9986:LOC100352750
uniprot id: G1T8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9986:LOC100342857
gene id: 9986:LOC100342857
uniprot id: H6V7B0
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9986:LOC100346914
gene id: 9986:LOC100346914
uniprot id: G1TIA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100339488
gene id: 9986:LOC100339488
uniprot id: G1SR79
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9986:LOC100339474
gene id: 9986:LOC100339474
uniprot id: G1SL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9986:LOC100338016
gene id: 9986:LOC100338016
uniprot id: G1T7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9986:LOC103351897
gene id: 9986:LOC103351897
uniprot id: G1ST50
names: Similarity
messages: Belongs to the TEX13 family.

9986:LOC100339410
gene id: 9986:LOC100339410
uniprot id: G1SJZ8
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

9986:LOC100358943
gene id: 9986:LOC100358943
uniprot id: G1TEC7
names: Similarity
messages: Belongs to the copine family.

9986:LOC100340726
gene id: 9986:LOC100340726
uniprot id: G1U313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346361
gene id: 9986:LOC100346361
uniprot id: G1T099
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9986:LOC100359231
gene id: 9986:LOC100359231
uniprot id: G1U0U5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9986:LOC100347162
gene id: 9986:LOC100347162
uniprot id: G1SQR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100356467
gene id: 9986:LOC100356467
uniprot id: G1SLB0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100338339
gene id: 9986:LOC100338339
uniprot id: G1SUM5
names: Similarity
messages: Belongs to the peptidase M67C family.

9986:LOC100356580
gene id: 9986:LOC100356580
uniprot id: G1SPL9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:LOC100347914
gene id: 9986:LOC100347914
uniprot id: U3KNU8
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9986:LOC100348066
gene id: 9986:LOC100348066
uniprot id: G1SY01
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100358251
gene id: 9986:LOC100358251
uniprot id: G1TD33
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100357194
gene id: 9986:LOC100357194
uniprot id: G1TMS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100348056
gene id: 9986:LOC100348056
uniprot id: G1SKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9986:LOC100337789
gene id: 9986:LOC100337789
uniprot id: G1TLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC103348280
gene id: 9986:LOC103348280
uniprot id: G1TTZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9986:CD38
gene id: 9986:CD38
uniprot id: G1TEG2
uniprot id: Q9MZ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Osteoclasts.
messages: Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.

9986:LOC100347837
gene id: 9986:LOC100347837
uniprot id: G1TPD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9986:DIO1
gene id: 9986:DIO1
uniprot id: A4GT88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

9986:LOC100350143
gene id: 9986:LOC100350143
uniprot id: A0A5F9CIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344246
gene id: 9986:LOC100344246
uniprot id: G1TJJ7
names: Function
messages: May be involved in neurite outgrowth.

9986:LOC100344177
gene id: 9986:LOC100344177
uniprot id: G1SIH1
names: Similarity
messages: Belongs to the PA28 family.

9986:LOC100348687
gene id: 9986:LOC100348687
uniprot id: G1T207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100352100
gene id: 9986:LOC100352100
uniprot id: G1TAK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9986:LOC100339581
gene id: 9986:LOC100339581
uniprot id: G1T4G9
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100350199
gene id: 9986:LOC100350199
uniprot id: G1T2W5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9986:LOC100340169
gene id: 9986:LOC100340169
uniprot id: A0A5F9DJU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9986:LOC100354214
gene id: 9986:LOC100354214
uniprot id: G1SII8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9986:LOC100343336
gene id: 9986:LOC100343336
uniprot id: G1SZG2
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100355058
gene id: 9986:LOC100355058
uniprot id: A0A5F9C7L2
uniprot id: A0A5F9CHC7
uniprot id: G1TRT7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9986:LOC100337822
gene id: 9986:LOC100337822
uniprot id: U3KM40
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9986:LOC100342909
gene id: 9986:LOC100342909
uniprot id: A0A5F9DEU0
uniprot id: G1SVV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9986:LOC100349529
gene id: 9986:LOC100349529
uniprot id: G1T7J7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100340389
gene id: 9986:LOC100340389
uniprot id: G1T077
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100342931
gene id: 9986:LOC100342931
uniprot id: G1TTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9986:LOC100339802
gene id: 9986:LOC100339802
uniprot id: A0A5F9D9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9986:LOC100344934
gene id: 9986:LOC100344934
uniprot id: G1ST08
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9986:LOC100355923
gene id: 9986:LOC100355923
uniprot id: G1T5B0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9986:LOC100355803
gene id: 9986:LOC100355803
uniprot id: G1SD50
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100337992
gene id: 9986:LOC100337992
uniprot id: G1U1Y3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9986:OLR110
gene id: 9986:OLR110
uniprot id: B8K169
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100353601
gene id: 9986:LOC100353601
uniprot id: A0A5F9DAR0
uniprot id: G1SJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9986:LOC100101607
gene id: 9986:LOC100101607
uniprot id: B7NZI4
names: Similarity
messages: Belongs to the peptidase M10A family.

9986:LOC108178217
gene id: 9986:LOC108178217
uniprot id: A0A5F9C497
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100344541
gene id: 9986:LOC100344541
uniprot id: G1ST23
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100350946
gene id: 9986:LOC100350946
uniprot id: A0A5F9C3N4
uniprot id: A0A5F9DPM1
uniprot id: G1TMZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9986:C7H2orf76
gene id: 9986:C7H2orf76
uniprot id: G1SM16
names: Similarity
messages: Belongs to the UPF0538 family.

9986:LOC100345148
gene id: 9986:LOC100345148
uniprot id: A0A5F9CCE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9986:OR52B6
gene id: 9986:OR52B6
uniprot id: B8K1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352836
gene id: 9986:LOC100352836
uniprot id: G1SYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9986:LOC100340261
gene id: 9986:LOC100340261
uniprot id: G1T920
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9986:LOC100357168
gene id: 9986:LOC100357168
uniprot id: G1U7D6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9986:LOC100343125
gene id: 9986:LOC100343125
uniprot id: G1T3E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9986:LOC100357073
gene id: 9986:LOC100357073
uniprot id: G1SX57
names: Similarity
messages: Belongs to the SGT family.

9986:LOC100356733
gene id: 9986:LOC100356733
uniprot id: G1TBB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9986:LOC100125995
gene id: 9986:LOC100125995
uniprot id: A7KAU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17442726). Mediates the secretion of cationic compounds including drugs, toxins and endogenous metabolites. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as creatinine, thiamine, agmatine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney and liver, into urine and bile respectively (By similarity).
messages: Predominantly expressed in kidney and liver.

9986:MET
gene id: 9986:MET
uniprot id: Q09YN5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9986:LOC100347317
gene id: 9986:LOC100347317
uniprot id: G1TDI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9986:LIPC
gene id: 9986:LIPC
uniprot id: O46559
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:1770315). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity).
messages: Homodimer.
messages: Secreted

9986:LOC100348407
gene id: 9986:LOC100348407
uniprot id: G1ST90
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9986:LOC100337736
gene id: 9986:LOC100337736
uniprot id: G1SP66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9986:INHBA
gene id: 9986:INHBA
uniprot id: S4VIU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9986:OLR109
gene id: 9986:OLR109
uniprot id: B8K168
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342267
gene id: 9986:LOC100342267
uniprot id: G1SEP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:CTNNA1
gene id: 9986:CTNNA1
uniprot id: Q59I72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation (By similarity).
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell junction
messages: Cell membrane
messages: Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin (By similarity). Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (By similarity). Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions (By similarity). The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex (By similarity). Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1 (By similarity). Binds AFDN and F-actin (By similarity). Interacts with ARHGAP21 (By similarity). Interacts with AJUBA (By similarity). Interacts with LIMA1 (By similarity). Interacts with vinculin/VCL (By similarity).
messages: Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
messages: Sumoylated.
messages: adherens junction
messages: cytoskeleton

9986:LOC100356872
gene id: 9986:LOC100356872
uniprot id: A0A5F9CR36
uniprot id: A0A5F9DEL8
uniprot id: G1U5A6
names: Similarity
messages: Belongs to the MON2 family.

9986:LOC100339067
gene id: 9986:LOC100339067
uniprot id: G1U115
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

9986:PTGS1
gene id: 9986:PTGS1
uniprot id: O97554
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Microsome membrane
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
messages: The cyclooxygenase activity is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, flurbiprofen, ketoprofen, naproxen, flurbiprofen, anirolac, fenclofenac and diclofenac.

9986:LOC100356969
gene id: 9986:LOC100356969
uniprot id: G1TB02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9986:LOC100358518
gene id: 9986:LOC100358518
uniprot id: G1SJN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9986:LOC100340081
gene id: 9986:LOC100340081
uniprot id: A0A5F9DVE8
uniprot id: G1SFH5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9986:LOC100344315
gene id: 9986:LOC100344315
uniprot id: A0A5F9CF19
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9986:VLDLR
gene id: 9986:VLDLR
uniprot id: A0A5F9DGG3
uniprot id: P35953
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in heart, muscle, and adipose tissue.
messages: Homooligomer. Binds to the extracellular matrix protein Reelin/RELN. Interacts with LRP8 (By similarity). Interacts with LDLRAP1 (By similarity). Interacts with SNX17 (By similarity). Interacts with DAB1. Interacts with PCSK9. Interacts with PAFAH1B3 and PAFAH1B2, the catalytic complex of (PAF-AH (I)) heterotetrameric enzyme; these interactions may modulate the Reelin pathway. Interacts with STX5; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane. Interacts with CLU (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
messages: Ubiquitinated at Lys-839 by MYLIP leading to degradation.
messages: clathrin-coated pit

9986:LOC100341887
gene id: 9986:LOC100341887
uniprot id: G1TCB6
names: Similarity
messages: Belongs to the DDIT4 family.

9986:LOC100351237
gene id: 9986:LOC100351237
uniprot id: G1U5J7
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100357932
gene id: 9986:LOC100357932
uniprot id: G1T0D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9986:LOC100346208
gene id: 9986:LOC100346208
uniprot id: G1TWC9
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9986:LOC100358671
gene id: 9986:LOC100358671
uniprot id: G1THZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9986:LOC100355840
gene id: 9986:LOC100355840
uniprot id: G1TZF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100352085
gene id: 9986:LOC100352085
uniprot id: G1TDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9986:LOC100354289
gene id: 9986:LOC100354289
uniprot id: A0A5F9CY54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9986:LOC100358852
gene id: 9986:LOC100358852
uniprot id: G1SE76
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9986:LOC100338434
gene id: 9986:LOC100338434
uniprot id: G1SLC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9986:CS
gene id: 9986:CS
uniprot id: A0A5F9DU85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9986:LOC100343561
gene id: 9986:LOC100343561
uniprot id: A0A5F9CES5
uniprot id: A0A5F9DSI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: Membrane

9986:NTAQ1
gene id: 9986:NTAQ1
uniprot id: G1T6W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9986:LOC100338717
gene id: 9986:LOC100338717
uniprot id: G1SEL6
names: Similarity
messages: Belongs to the FPG family.

9986:SERPINB2
gene id: 9986:SERPINB2
uniprot id: B7NZ99
names: Similarity
messages: Belongs to the serpin family.

9986:LOC100357669
gene id: 9986:LOC100357669
uniprot id: G1T2S5
names: Similarity
messages: Belongs to the LEO1 family.

9986:LOC100341537
gene id: 9986:LOC100341537
uniprot id: G1SIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9986:OR51I2
gene id: 9986:OR51I2
uniprot id: B8K185
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354188
gene id: 9986:LOC100354188
uniprot id: G1SZJ4
names: Subcellular Location Annotation
messages: nucleolus

9986:PRKCB
gene id: 9986:PRKCB
uniprot id: P05772
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2…
messages: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615) (By similarity).
messages: Cytoplasm
messages: Interacts with PDK1. Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR (By similarity).
messages: Membrane
messages: Nucleus
messages: Phosphorylation on 'Thr-499' of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly, isoform beta-II is autophosphorylated on 'Thr-640' and 'Ser-659', subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).

9986:LOC100357486
gene id: 9986:LOC100357486
uniprot id: G1TCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9986:LOC100344678
gene id: 9986:LOC100344678
uniprot id: G1SWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9986:LOC100347186
gene id: 9986:LOC100347186
uniprot id: G1SDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

9986:LOC100346428
gene id: 9986:LOC100346428
uniprot id: G1TT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100344154
gene id: 9986:LOC100344154
uniprot id: G1U8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9986:LOC100125981
gene id: 9986:LOC100125981
uniprot id: A0A5F9D5L2
uniprot id: Q9XSC2
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Deoxyglucose transport is inhibit by D-glucose, D-galactose and maltose. Galactose transport is inhibited by D-glucose and maltose.
messages: Detected in stomach, placenta, lung and brain.
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9986:LOC100358896
gene id: 9986:LOC100358896
uniprot id: A0A5F9CQQ2
names: Similarity
messages: Belongs to the peptidase C2 family.

9986:LOC100342561
gene id: 9986:LOC100342561
uniprot id: G1TCW1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9986:LOC100342074
gene id: 9986:LOC100342074
uniprot id: G1SRQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9986:LOC100345952
gene id: 9986:LOC100345952
uniprot id: G1T7Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton
messages: sarcomere

9986:LOC100350574
gene id: 9986:LOC100350574
uniprot id: G1SU36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9986:LOC100339222
gene id: 9986:LOC100339222
uniprot id: G1TA25
names: Similarity
messages: Belongs to the SMARCD family.

9986:LOC100359319
gene id: 9986:LOC100359319
uniprot id: A0A5F9CT19
names: Similarity
messages: Belongs to the RASGRP family.

9986:LOC100339908
gene id: 9986:LOC100339908
uniprot id: G1SVK0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:CLPS
gene id: 9986:CLPS
uniprot id: P42890
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the colipase family.
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Expressed by the pancreas.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9986:LOC100358459
gene id: 9986:LOC100358459
uniprot id: G1T9T2
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100358876
gene id: 9986:LOC100358876
uniprot id: A0A5F9D2T8
uniprot id: G1SVY9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9986:LOC100346166
gene id: 9986:LOC100346166
uniprot id: G1U7Z1
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100353556
gene id: 9986:LOC100353556
uniprot id: G1T0N2
names: Similarity
messages: Belongs to the cyclin family.

9986:LOC100342616
gene id: 9986:LOC100342616
uniprot id: A0A5F9DL67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100342523
gene id: 9986:LOC100342523
uniprot id: G1U841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC100101598
gene id: 9986:LOC100101598
uniprot id: G1T0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9986:ADRA1D
gene id: 9986:ADRA1D
uniprot id: O02666
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling.
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9986:LOC100339551
gene id: 9986:LOC100339551
uniprot id: G1SIJ9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9986:LOC100343526
gene id: 9986:LOC100343526
uniprot id: G1U202
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9986:LOC100350337
gene id: 9986:LOC100350337
uniprot id: A0A5F9C432
uniprot id: A0A5F9CMF5
uniprot id: A0A5F9DBM9
uniprot id: A0A5F9DGD5
uniprot id: G1SU30
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9986:TIMP3
gene id: 9986:TIMP3
uniprot id: G1SUX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9986:LOC100009266
gene id: 9986:LOC100009266
uniprot id: P11645
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9986:LOC100359107
gene id: 9986:LOC100359107
uniprot id: A0A5F9DA95
uniprot id: G1STG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9986:KCND2
gene id: 9986:KCND2
uniprot id: P59995
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Detected in brain frontal cortex.
messages: Homotetramer or heterotetramer with KCND1 or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DPP6, DPP10, DLG4 and DLG1. In vivo, probably exists as heteromeric complex containing variable proportions of KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). The tetrameric channel can associate with up to four regulatory subunits, such as KCNIP2 or KCNIP4 (By similarity). Interaction with KCNIP3 promotes tetramerization and formation of a functional potassium channel (By similarity). Interaction with four KCNIP4 chains does not reduce interaction with DPP10 (By similarity). Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (By similarity). Interacts with FLNA and FLNC (By similarity). Interacts with NCS1/FREQ (By similarity). Identified in a complex with cAMP-dependent protein kinase (PKA), CAV3, AKAP6 and KCND3 in cardiac myocytes (By similarity).
messages: Is specifically and reversibly inhibited by the scorpion toxin Ts8 (AC P69940).
messages: Perikaryon
messages: Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites. Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552. Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3. Phosphorylation at Ser-552 leads to KCND2 internalization (By similarity). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (By similarity). Phosphorylation at Ser-616 is required for the down-regulation of neuronal A-type currents in response to signaling via GRM5 (By similarity).
messages: Postsynaptic cell membrane
messages: Synapse
messages: The C-terminal cytoplasmic region is important for normal expression at the cell membrane and modulates the voltage-dependence of channel activation and inactivation. It is required for interaction with KCNIP2, and probably other family members as well.
messages: The N-terminal cytoplasmic region can mediate N-type inactivation by physically blocking the channel (By similarity). This probably does not happen in vivo, where the N-terminal region mediates interaction with regulatory subunits, such as KCNIP1 and KCNIP2 (By similarity). The zinc binding sites in the N-terminal domain are important for tetramerization and assembly of a functional channel complex (By similarity). Most likely, the channel undergoes closed-state inactivation, where a subtle conformation change would render the protein less sensitive to activation.
messages: The transient neuronal A-type potassium current called I(SA) is triggered at membrane potentials that are below the threshold for action potentials. It inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KCND2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac I(to) current differs between species; it is mediated by KCND2 in rodents. In human and other non-rodents KCND3 may play an equivalent role.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel…
messages: caveola
messages: dendrite
messages: dendritic spine
messages: sarcolemma

9986:LOC100339069
gene id: 9986:LOC100339069
uniprot id: G1TAD1
names: Similarity
messages: Belongs to the dymeclin family.

9986:LOC100343704
gene id: 9986:LOC100343704
uniprot id: G1TUY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9986:LOC100350174
gene id: 9986:LOC100350174
uniprot id: G1SRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9986:LOC100340158
gene id: 9986:LOC100340158
uniprot id: G1SHH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9986:LOC100347687
gene id: 9986:LOC100347687
uniprot id: A0A5F9CY19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9986:LOC100355546
gene id: 9986:LOC100355546
uniprot id: G1TTP9
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9986:RTRAF
gene id: 9986:RTRAF
uniprot id: G1T7W2
names: Similarity
messages: Belongs to the RTRAF family.

9986:LOC100347245
gene id: 9986:LOC100347245
uniprot id: G1T1M5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9986:LOC100346702
gene id: 9986:LOC100346702
uniprot id: G1T8H5
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9986:LOC100344135
gene id: 9986:LOC100344135
uniprot id: G1SF06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9986:C8B
gene id: 9986:C8B
uniprot id: P98137
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).
messages: Secreted

9986:CYP2C
gene id: 9986:CYP2C
uniprot id: P00182
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Constitutively expressed.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9986:LOC100348900
gene id: 9986:LOC100348900
uniprot id: G1SFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9986:LOC100353589
gene id: 9986:LOC100353589
uniprot id: G1SPH2
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9986:YAE1
gene id: 9986:YAE1
uniprot id: G1T1E4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9986:RGN
gene id: 9986:RGN
uniprot id: Q9TTJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
messages: Monomer.

9986:TYR
gene id: 9986:TYR
uniprot id: Q9MYI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9986:LOC100358726
gene id: 9986:LOC100358726
uniprot id: G1SUG0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9986:LOC100340089
gene id: 9986:LOC100340089
uniprot id: A0A5F9DP32
uniprot id: G1U194
names: Similarity
messages: Belongs to the Luc7 family.

9986:LOC100347623
gene id: 9986:LOC100347623
uniprot id: G1TCT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9986:LOC100341945
gene id: 9986:LOC100341945
uniprot id: G1TCU9
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100344105
gene id: 9986:LOC100344105
uniprot id: G1TFQ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100344634
gene id: 9986:LOC100344634
uniprot id: G1TXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356219
gene id: 9986:LOC100356219
uniprot id: A0A5F9DUQ1
names: Similarity
messages: Belongs to the ARTD/PARP family.

9986:LOC100350417
gene id: 9986:LOC100350417
uniprot id: G1TZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9986:LOC100352521
gene id: 9986:LOC100352521
uniprot id: G1TBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:KCND3
gene id: 9986:KCND3
uniprot id: A0A5F9C922
uniprot id: Q9TTT5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.
messages: Cell membrane
messages: Detected in carotid body chemoreceptor cells and in frontal cortex.
messages: Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DLG1, KCNE1, KCNE2, SCN1B and KCNAB1 (By similarity).
messages: Membrane
messages: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
messages: Regulated through phosphorylation at Ser-569 by CaMK2D.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: dendrite
messages: sarcolemma

9986:LOC100358267
gene id: 9986:LOC100358267
uniprot id: A0A5F9CLT8
names: Subcellular Location Annotation
messages: Cytoplasm

9986:LOC100355889
gene id: 9986:LOC100355889
uniprot id: G1SZ59
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9986:LOC100340645
gene id: 9986:LOC100340645
uniprot id: G1TPV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100350524
gene id: 9986:LOC100350524
uniprot id: G1SLL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9986:LOC100340997
gene id: 9986:LOC100340997
uniprot id: G1SZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9986:LOC100338965
gene id: 9986:LOC100338965
uniprot id: G1SGN6
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9986:LOC100356813
gene id: 9986:LOC100356813
uniprot id: A0A5F9D0E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9986:LOC100346861
gene id: 9986:LOC100346861
uniprot id: A0A5F9CYN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100347187
gene id: 9986:LOC100347187
uniprot id: A0A5F9DMG4
uniprot id: G1STE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100349372
gene id: 9986:LOC100349372
uniprot id: G1SS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100341597
gene id: 9986:LOC100341597
uniprot id: G1SUY5
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9986:PI4KB
gene id: 9986:PI4KB
uniprot id: B7NZD4
uniprot id: U3KP92
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9986:LOC100358116
gene id: 9986:LOC100358116
uniprot id: G1SRT0
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100347511
gene id: 9986:LOC100347511
uniprot id: A0A5F9C5R6
uniprot id: A0A5F9DL64
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9986:LOC100342604
gene id: 9986:LOC100342604
uniprot id: A0A5F9CUS7
uniprot id: G1T2F0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9986:LOC100357761
gene id: 9986:LOC100357761
uniprot id: G1T0M8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9986:LOC100338889
gene id: 9986:LOC100338889
uniprot id: G1SF62
names: Similarity
messages: Belongs to the isthmin family.

9986:LOC100348333
gene id: 9986:LOC100348333
uniprot id: A0A5F9CV74
uniprot id: G1TW60
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100354711
gene id: 9986:LOC100354711
uniprot id: G1T486
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9986:LOC100352837
gene id: 9986:LOC100352837
uniprot id: G1SQI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:MYC
gene id: 9986:MYC
uniprot id: G1T737
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: nucleolus
messages: nucleoplasm

9986:LOC100349778
gene id: 9986:LOC100349778
uniprot id: A0A5F9D8E1
uniprot id: A0A5F9DV07
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9986:LOC100339312
gene id: 9986:LOC100339312
uniprot id: G1SE45
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9986:LOC103351138
gene id: 9986:LOC103351138
uniprot id: G1SRS7
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100346187
gene id: 9986:LOC100346187
uniprot id: G1U168
names: Similarity
messages: Belongs to the complex I LYR family.

9986:LOC100357590
gene id: 9986:LOC100357590
uniprot id: G1TEB9
names: Similarity
messages: Belongs to the BRINP family.

9986:HOXA6
gene id: 9986:HOXA6
uniprot id: B7NZT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:OLFR572
gene id: 9986:OLFR572
uniprot id: B8K150
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:HOXA3
gene id: 9986:HOXA3
uniprot id: B7NZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9986:LOC100346467
gene id: 9986:LOC100346467
uniprot id: A0A5F9DED5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9986:INTS13
gene id: 9986:INTS13
uniprot id: G1SUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9986:LOC100341533
gene id: 9986:LOC100341533
uniprot id: W8W3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:PRDM4
gene id: 9986:PRDM4
uniprot id: B7NZN2
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9986:VWF
gene id: 9986:VWF
uniprot id: F5XVB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9986:LOC100354100
gene id: 9986:LOC100354100
uniprot id: G1T3L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9986:LOC100342224
gene id: 9986:LOC100342224
uniprot id: G1SSG3
names: Similarity
messages: Belongs to the copine family.

9986:LOC100338079
gene id: 9986:LOC100338079
uniprot id: G1SN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9986:LOC100358557
gene id: 9986:LOC100358557
uniprot id: G1SCF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9986:LOC100338417
gene id: 9986:LOC100338417
uniprot id: G1TAW7
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9986:IL18
gene id: 9986:IL18
uniprot id: B1A3U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9986:LOC100351261
gene id: 9986:LOC100351261
uniprot id: G1SML6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9986:LOC100357362
gene id: 9986:LOC100357362
uniprot id: G1TNU7
names: Similarity
messages: Belongs to the CWF19 family.

9986:LOC100352839
gene id: 9986:LOC100352839
uniprot id: G1TAR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC108177262
gene id: 9986:LOC108177262
uniprot id: A0A5F9DSP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100346135
gene id: 9986:LOC100346135
uniprot id: G1TC72
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9986:LOC100358813
gene id: 9986:LOC100358813
uniprot id: G1SIG2
uniprot id: G1T7R2
names: Similarity
messages: Belongs to the 14-3-3 family.
messages: Belongs to the CRK family.

9986:LOC100341092
gene id: 9986:LOC100341092
uniprot id: G1SNK1
names: Similarity
messages: Belongs to the NPR2 family.

9986:TRPV1
gene id: 9986:TRPV1
uniprot id: Q6RX08
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Interacts with PIRT (By similarity). Homotetramer. May also form a heteromeric channel with TRPV3. Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with the Scolopendra mutilans RhTx toxin (By similarity). Interacts with TMEM100 (By similarity). Interacts with PACS2 (By similarity).
messages: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:14996838, PubMed:11035011). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel (By similarity).
messages: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
messages: Postsynaptic cell membrane
messages: The association domain (AD) is necessary for self-association.
messages: The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). The Scolopendra mutilans RhTx toxin potentiates the heat activation pathway mediated by this channel by binding to the charge-rich outer pore region (in an activated state) (By similarity). Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity. Intracellular PIP2 inhibits desensitization (By similarity).
messages: dendritic spine membrane

9986:LOC100358822
gene id: 9986:LOC100358822
uniprot id: G1SIV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9986:LOC100343306
gene id: 9986:LOC100343306
uniprot id: G1SKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9986:LOC100343087
gene id: 9986:LOC100343087
uniprot id: G1T958
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100348177
gene id: 9986:LOC100348177
uniprot id: G1TBF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9986:LOC100358139
gene id: 9986:LOC100358139
uniprot id: G1U205
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9986:LOC100348148
gene id: 9986:LOC100348148
uniprot id: G1TIZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9986:LOC100356089
gene id: 9986:LOC100356089
uniprot id: G1SNR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345627
gene id: 9986:LOC100345627
uniprot id: G1T824
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9986:LOC100346302
gene id: 9986:LOC100346302
uniprot id: G1SGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

9986:LOC100354973
gene id: 9986:LOC100354973
uniprot id: A0A5F9CBF4
uniprot id: A0A5F9CNN4
uniprot id: A0A5F9D2E6
uniprot id: G1T3D8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9986:KEF51 p07
gene id: 9986:KEF51_p07
uniprot id: A0A3Q8UF91
uniprot id: O79433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100351655
gene id: 9986:LOC100351655
uniprot id: G1SFG5
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100350456
gene id: 9986:LOC100350456
uniprot id: G1SCE4
uniprot id: U3KM64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9986:LOC100341148
gene id: 9986:LOC100341148
uniprot id: G1T6X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9986:LOC100346389
gene id: 9986:LOC100346389
uniprot id: G1SFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100346719
gene id: 9986:LOC100346719
uniprot id: A0A5F9CFS1
uniprot id: G1T5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9986:LOC100355110
gene id: 9986:LOC100355110
uniprot id: G1SCE7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9986:LOC100351222
gene id: 9986:LOC100351222
uniprot id: A0A5F9D1M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100349741
gene id: 9986:LOC100349741
uniprot id: A0A5F9DFJ4
uniprot id: G1SSX8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

9986:LOC100346130
gene id: 9986:LOC100346130
uniprot id: G1U079
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358962
gene id: 9986:LOC100358962
uniprot id: G1U443
names: Subcellular Location Annotation
messages: Mitochondrion

9986:CSN3
gene id: 9986:CSN3
uniprot id: P33618
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9986:LOC100342985
gene id: 9986:LOC100342985
uniprot id: G1SIF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9986:LOC100340219
gene id: 9986:LOC100340219
uniprot id: G1SPI3
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:LOC100358240
gene id: 9986:LOC100358240
uniprot id: A0A5F9DSA8
uniprot id: G1T4X7
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9986:LOC100358465
gene id: 9986:LOC100358465
uniprot id: G1SVC4
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9986:LOC100354550
gene id: 9986:LOC100354550
uniprot id: A0A5F9D581
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:LOC100353962
gene id: 9986:LOC100353962
uniprot id: G1TF82
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9986:LOC100352578
gene id: 9986:LOC100352578
uniprot id: G1TV42
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9986:LOC100349882
gene id: 9986:LOC100349882
uniprot id: G1SLD7
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9986:LOC100346096
gene id: 9986:LOC100346096
uniprot id: G1TTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9986:MINDY1
gene id: 9986:MINDY1
uniprot id: G1SMB6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9986:LOC100357892
gene id: 9986:LOC100357892
uniprot id: P43348
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Interacts with STEAP3.
messages: Involved in calcium binding and microtubule stabilization.
messages: Undergoes developmental regulation during mammary gland development.

9986:LOC100356058
gene id: 9986:LOC100356058
uniprot id: G1TEB7
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9986:LOC100350568
gene id: 9986:LOC100350568
uniprot id: G1T942
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9986:LOC100357763
gene id: 9986:LOC100357763
uniprot id: A0A5F9C2W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9986:LOC103351966
gene id: 9986:LOC103351966
uniprot id: U3KMH4
names: Subcellular Location Annotation
messages: Nucleus

9986:ITGB3
gene id: 9986:ITGB3
uniprot id: G1TSS7
uniprot id: Q9TUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane
messages: focal adhesion

9986:LOC100348012
gene id: 9986:LOC100348012
uniprot id: G1T6H5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:JPH1
gene id: 9986:JPH1
uniprot id: Q9GKY8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.

9986:LOC100352263
gene id: 9986:LOC100352263
uniprot id: G1SHT5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100347408
gene id: 9986:LOC100347408
uniprot id: G1SVL8
names: Similarity
messages: Belongs to the thymidylate synthase family.

9986:LOC103350772
gene id: 9986:LOC103350772
uniprot id: U3KNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9986:LOC100357388
gene id: 9986:LOC100357388
uniprot id: A0A5F9CAE3
uniprot id: A0A5F9DC26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9986:LOC100351730
gene id: 9986:LOC100351730
uniprot id: A0A5F9D031
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9986:LOC100352308
gene id: 9986:LOC100352308
uniprot id: G1TZG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9986:LOC100349330
gene id: 9986:LOC100349330
uniprot id: G1STX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9986:ADCY5
gene id: 9986:ADCY5
uniprot id: P40144
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by forskolin. Activated by GNAS. Activity is further increased by interaction with the G protein beta and gamma subunit complex formed by GNB1 and GNG2 (By similarity). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (By similarity). Phosphorylation by RAF1 results in its activation (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.
messages: Cell membrane
messages: Interacts with GNAS, GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (By similarity).
messages: Myocardial tissue.
messages: Phosphorylated by RAF1.
messages: The N-terminus is blocked.
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
messages: cilium

9986:LOC100346206
gene id: 9986:LOC100346206
uniprot id: A0A5F9C6F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9986:LOC100350501
gene id: 9986:LOC100350501
uniprot id: G1SLD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9986:LOC100347240
gene id: 9986:LOC100347240
uniprot id: G1TDR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343208
gene id: 9986:LOC100343208
uniprot id: G1SVD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9986:LOC100355077
gene id: 9986:LOC100355077
uniprot id: G1U0W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9986:PNRC2
gene id: 9986:PNRC2
uniprot id: A0A5F9CJI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9986:LOC103347864
gene id: 9986:LOC103347864
uniprot id: A0A5F9C5M4
uniprot id: G1TP79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9986:LOC100346903
gene id: 9986:LOC100346903
uniprot id: G1TKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9986:LOC100354614
gene id: 9986:LOC100354614
uniprot id: A0A5F9DDL7
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9986:LOC100358445
gene id: 9986:LOC100358445
uniprot id: G1SDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9986:LOC100343745
gene id: 9986:LOC100343745
uniprot id: G1SQG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100359061
gene id: 9986:LOC100359061
uniprot id: G1SFI4
uniprot id: U3KMT3
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100339798
gene id: 9986:LOC100339798
uniprot id: G1SJ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100345684
gene id: 9986:LOC100345684
uniprot id: G1SRT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100339740
gene id: 9986:LOC100339740
uniprot id: G1U058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9986:LOC100343220
gene id: 9986:LOC100343220
uniprot id: G1TBS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:TLCD3A
gene id: 9986:TLCD3A
uniprot id: A0A5F9CVC5
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100342208
gene id: 9986:LOC100342208
uniprot id: G1T937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9986:LOC100337704
gene id: 9986:LOC100337704
uniprot id: G1SYR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9986:CBY2
gene id: 9986:CBY2
uniprot id: G1T6L4
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1.

9986:LOC100357260
gene id: 9986:LOC100357260
uniprot id: G1SPM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9986:LOC100342533
gene id: 9986:LOC100342533
uniprot id: A0A5F9DBB0
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100351807
gene id: 9986:LOC100351807
uniprot id: G1SY53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9986:LOC100359048
gene id: 9986:LOC100359048
uniprot id: A0A5F9CID2
uniprot id: A0A5F9CS29
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9986:LOC100351525
gene id: 9986:LOC100351525
uniprot id: G1T8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9986:LOC100339405
gene id: 9986:LOC100339405
uniprot id: G1SZF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9986:LOC100338232
gene id: 9986:LOC100338232
uniprot id: A0A5F9C6Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9986:LOC103351891
gene id: 9986:LOC103351891
uniprot id: U3KN56
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100344921
gene id: 9986:LOC100344921
uniprot id: G1SLI2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100342870
gene id: 9986:LOC100342870
uniprot id: G1SNE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:VPS72
gene id: 9986:VPS72
uniprot id: B7NZD1
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9986:LOC100343225
gene id: 9986:LOC100343225
uniprot id: G1TSW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9986:CRYBG2
gene id: 9986:CRYBG2
uniprot id: A0A5F9DTN3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9986:LOC108178369
gene id: 9986:LOC108178369
uniprot id: G1TNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356101
gene id: 9986:LOC100356101
uniprot id: G1U8K8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9986:LOC103349305
gene id: 9986:LOC103349305
uniprot id: G1U0Q2
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

9986:LOC100340090
gene id: 9986:LOC100340090
uniprot id: G1SH49
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9986:ATP2B1
gene id: 9986:ATP2B1
uniprot id: Q00804
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
messages: Cell membrane
messages: Isoform B is ubiquitously expressed and is the most predominant isoform. Isoform C is expressed at much lower levels in all tissues tested, but liver, while isoform A is found only in aorta, brain and stomach.
messages: Isoforms A and C contain and additional calmodulin-binding subdomain B which is different in the different splice variants and shows pH dependent calmodulin binding properties.
messages: Monomer. Dimer. Oligomer. Calmodulin binding. Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with YWHAE; interacts with the monomeric and dimeric forms of the YWHAE but prefer the monomer form; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with NPTN; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with EPB41; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).
messages: Presynaptic cell membrane
messages: Synapse
messages: synaptic vesicle membrane

9986:LOC100357929
gene id: 9986:LOC100357929
uniprot id: G1U0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100328912
gene id: 9986:LOC100328912
uniprot id: P00169
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9986:ELP1
gene id: 9986:ELP1
uniprot id: Q8WND5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).
messages: Cytoplasm
messages: Homodimer; dimerization promotes ELP1 stability and elongator complex formation. Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta.
messages: Nucleus
messages: Phosphorylated.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

9986:LOC100357006
gene id: 9986:LOC100357006
uniprot id: A0A5F9CEX6
uniprot id: G1TZE2
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9986:PTH1R
gene id: 9986:PTH1R
uniprot id: G1T397
uniprot id: Q9GMD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9986:PPM1A
gene id: 9986:PPM1A
uniprot id: A0A5F9DI64
uniprot id: P35814
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity).
messages: Membrane
messages: Monomer (By similarity). Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling (By similarity). Interacts with the phosphorylated form of IKBKB/IKKB (By similarity).
messages: N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
messages: Nucleus
messages: cytosol

9986:LOC100339699
gene id: 9986:LOC100339699
uniprot id: A0A5F9C2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:ZSCAN29
gene id: 9986:ZSCAN29
uniprot id: B7NZE3
uniprot id: G1T0Y7
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9986:LOC100343498
gene id: 9986:LOC100343498
uniprot id: A0A5F9C9I9
uniprot id: A0A5F9CSX7
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

9986:LOC100354452
gene id: 9986:LOC100354452
uniprot id: G1TUK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9986:LOC100348321
gene id: 9986:LOC100348321
uniprot id: G1SX75
names: Similarity
messages: Belongs to the lipin family.

9986:ARNT
gene id: 9986:ARNT
uniprot id: O02748
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Monomer. Homodimer only upon binding to a DNA (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TACC3 (By similarity). Interacts with HIF1A, EPAS1, NPAS1 and NPAS3; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Forms a heterodimer with AHRR, as well as with other bHLH proteins. Interacts with NOCA7 (By similarity). Interacts with TACC3 (By similarity). Interacts with AHR; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Interacts with SIM1 and NPAS4 (By similarity).
messages: Nucleus
messages: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).
messages: Was expressed at almost the same level in all tissues except for the heart, liver, and small intestine.

9986:LOC100353183
gene id: 9986:LOC100353183
uniprot id: G1TP37
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9986:LOC100344057
gene id: 9986:LOC100344057
uniprot id: G1T9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9986:LOC100341120
gene id: 9986:LOC100341120
uniprot id: G1T6X1
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100339139
gene id: 9986:LOC100339139
uniprot id: A0A5F9D9H0
uniprot id: G1T642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion
messages: Nucleus

9986:LOC108177009
gene id: 9986:LOC108177009
uniprot id: G1TWZ0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9986:PAX6
gene id: 9986:PAX6
uniprot id: Q38L55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9986:KEF51 p13
gene id: 9986:KEF51_p13
uniprot id: A0A3S8V6X7
uniprot id: O79427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9986:LOC100348912
gene id: 9986:LOC100348912
uniprot id: G1SIW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Cytoplasm

9986:HAS2
gene id: 9986:HAS2
uniprot id: Q95M16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9986:LOC100344631
gene id: 9986:LOC100344631
uniprot id: G1SXN4
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9986:LOC100351471
gene id: 9986:LOC100351471
uniprot id: G1U2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100343422
gene id: 9986:LOC100343422
uniprot id: G1SWS0
uniprot id: G1T6X4
names: Similarity
messages: Belongs to the intermediate filament family.

9986:LOC100348220
gene id: 9986:LOC100348220
uniprot id: G1SMD9
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9986:LOC100338597
gene id: 9986:LOC100338597
uniprot id: G1T5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9986:LOC100349301
gene id: 9986:LOC100349301
uniprot id: G1TFC1
names: Similarity
messages: Belongs to the GAB family.

9986:LOC100339036
gene id: 9986:LOC100339036
uniprot id: G1SR13
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9986:LOC100342436
gene id: 9986:LOC100342436
uniprot id: A0A5F9C3X1
uniprot id: G1TI02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9986:BPGM
gene id: 9986:BPGM
uniprot id: P07952
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate.
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Expressed in red blood cells.
messages: Homodimer.
messages: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.

9986:PPP3CB
gene id: 9986:PPP3CB
uniprot id: Q8HZM9
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9986:LOC100339243
gene id: 9986:LOC100339243
uniprot id: A0A5F9CZU3
names: Similarity
messages: Belongs to the TUB family.

9986:LOC100350572
gene id: 9986:LOC100350572
uniprot id: G1TMS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9986:LOC100356990
gene id: 9986:LOC100356990
uniprot id: A0A5F9CMW3
uniprot id: G1SXB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9986:SLC22A2
gene id: 9986:SLC22A2
uniprot id: Q8MJI6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Expressed in kidney.
messages: May be down-regulated in diabetic patients.
messages: Mediates tubular uptake of organic compounds from circulation. Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity). Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), 1-methyl-4-phenylpyridinium (MPP), cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity). Mediates tubular uptake of tetraethylammonium (TEA) and cimetidine.
messages: Membrane

9986:LOC100356925
gene id: 9986:LOC100356925
uniprot id: G1SZU8
names: Similarity
messages: Belongs to the AAA ATPase family.

9986:EDNRA
gene id: 9986:EDNRA
uniprot id: A5A8K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9986:LOC100358558
gene id: 9986:LOC100358558
uniprot id: G1T389
names: Subcellular Location Annotation
messages: cytoskeleton

9986:LOC100340270
gene id: 9986:LOC100340270
uniprot id: A0A5F9DMZ0
uniprot id: G1SXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9986:LOC100347410
gene id: 9986:LOC100347410
uniprot id: G1SEQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9986:LOC100355439
gene id: 9986:LOC100355439
uniprot id: A0A5F9D6D3
uniprot id: B7NZK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9986:LOC100345435
gene id: 9986:LOC100345435
uniprot id: G1TCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9986:LOC100348520
gene id: 9986:LOC100348520
uniprot id: G1SW53
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9986:MME
gene id: 9986:MME
uniprot id: A0A5F9D6I8
uniprot id: P08049
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
messages: Inhibited by mixanpril, an orally-active drug used for the treatment of hypertension.
messages: Membrane
messages: Myristoylation is a determinant of membrane targeting.
messages: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:3162886). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity).

9986:LOC103344935
gene id: 9986:LOC103344935
uniprot id: G1T0N4
names: Similarity
messages: Belongs to the nucleoplasmin family.

9986:LOC100344974
gene id: 9986:LOC100344974
uniprot id: A0A5F9CYN8
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9986:LOC100349663
gene id: 9986:LOC100349663
uniprot id: G1SWQ3
names: Similarity
messages: Belongs to the centrin family.

9986:LOC100354988
gene id: 9986:LOC100354988
uniprot id: G1TFK3
names: Subcellular Location Annotation
messages: Membrane

9986:PRKG1
gene id: 9986:PRKG1
uniprot id: A0A5F9CDA8
uniprot id: O77676
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 65 kDa monomer is produced by proteolytic cleavage.
messages: Autophosphorylation increases kinase activity.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: Composed of an N-terminal leucine-zipper domain followed by an autoinhibitory domain, which mediate homodimer formation and inhibit kinase activity, respectively. Next, two cGMP-binding domains are followed by the catalytic domain at the C-terminus. Binding of cGMP to cGMP-binding domains results in a conformational change that activates kinase activity by removing the autoinhibitory domain from the catalytic cleft leaving the catalytic domain free to phosphorylate downstream substrates. Isoforms alpha and beta have identical cGMP-binding and catalytic domains but differ in their leucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity (By similarity).
messages: Cytoplasm
messages: Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase.
messages: In the absence of cGMP, PRKG1 activity is suppressed by autoinhibitory contacts.
messages: Isoform alpha: parallel homodimer or heterodimer and also heterotetramer. Interacts directly with PPP1R12A. Non-covalent dimer of dimer of PRKG1-PRKG1 and PPP1R12A-PPP1R12A. This interaction targets PRKG1 to stress fibers to mediate smooth muscle cell relaxation and vasodilation in responses to rises in cGMP (By similarity). Isoform beta: antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with IRAG1 (By similarity). Forms a stable complex with ITPR1, IRAG1, and isoform beta of PRKG1 (By similarity). Interacts with TRPC7 (via ankyrin repeat domain) (By similarity). Isoform alpha interacts with RGS2 (By similarity). Interacts with GTF2I (By similarity).
messages: Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in…

9986:LOC100352919
gene id: 9986:LOC100352919
uniprot id: G1TKZ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100357026
gene id: 9986:LOC100357026
uniprot id: G1SU01
names: Similarity
messages: Belongs to the NipSnap family.

9986:LOC100340828
gene id: 9986:LOC100340828
uniprot id: A0A5F9DNT3
uniprot id: G1SZS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9986:LOC100345412
gene id: 9986:LOC100345412
uniprot id: A0A5F9C6E0
uniprot id: A0A5F9D6D5
uniprot id: G1SLV4
names: Subcellular Location Annotation
messages: Membrane

9986:PALS1
gene id: 9986:PALS1
uniprot id: A0A5F9DMW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

9986:LOC100344071
gene id: 9986:LOC100344071
uniprot id: G1U0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9986:LOC103351878
gene id: 9986:LOC103351878
uniprot id: U3KM46
names: Similarity
messages: Belongs to the DMRT family.

9986:LOC100342275
gene id: 9986:LOC100342275
uniprot id: G1U8G0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9986:LOC100345410
gene id: 9986:LOC100345410
uniprot id: A0A5F9C9N4
uniprot id: A0A5F9D012
uniprot id: A0A5F9D792
uniprot id: A0A5F9DI21
uniprot id: G1SDC4
names: Similarity
messages: Belongs to the OXR1 family.

9986:ZUP1
gene id: 9986:ZUP1
uniprot id: A0A5F9D5X0
uniprot id: G1STU5
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9986:LOC100342232
gene id: 9986:LOC100342232
uniprot id: A0A5F9CKM4
uniprot id: G1T7E6
names: Similarity
messages: Belongs to the MAX family.

9986:LOC100345268
gene id: 9986:LOC100345268
uniprot id: G1SMJ0
names: Subcellular Location Annotation
messages: nuclear pore complex

9986:LOC100347179
gene id: 9986:LOC100347179
uniprot id: G1TFE7
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100342060
gene id: 9986:LOC100342060
uniprot id: G1SLW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9986:LOC103348211
gene id: 9986:LOC103348211
uniprot id: A0A5F9CGX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9986:LOC100358899
gene id: 9986:LOC100358899
uniprot id: G1T9E9
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100345905
gene id: 9986:LOC100345905
uniprot id: G1TDQ8
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9986:LOC103350045
gene id: 9986:LOC103350045
uniprot id: A0A5F9CTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9986:PLA2G4E
gene id: 9986:PLA2G4E
uniprot id: G1TFQ6
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9986:LOC100339409
gene id: 9986:LOC100339409
uniprot id: G1SEZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9986:LOC100346998
gene id: 9986:LOC100346998
uniprot id: G1TX36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport.
messages: Membrane

9986:LOC100357591
gene id: 9986:LOC100357591
uniprot id: G1SCZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9986:LOC100357909
gene id: 9986:LOC100357909
uniprot id: A0A5F9D121
uniprot id: G1SUW2
names: Similarity
messages: Belongs to the FAX family.

9986:LOC100344425
gene id: 9986:LOC100344425
uniprot id: G1SEM1
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9986:LOC108175375
gene id: 9986:LOC108175375
uniprot id: Q9XS97
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNURF family.
messages: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
messages: Nucleus

9986:LOC100354306
gene id: 9986:LOC100354306
uniprot id: W0UUZ5
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9986:LOC100355364
gene id: 9986:LOC100355364
uniprot id: G1SFD7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9986:LOC100354787
gene id: 9986:LOC100354787
uniprot id: G1TE35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9986:LOC100340725
gene id: 9986:LOC100340725
uniprot id: G1U3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100358270
gene id: 9986:LOC100358270
uniprot id: A0A654ID53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9986:LOC100342635
gene id: 9986:LOC100342635
uniprot id: G1U2Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100345003
gene id: 9986:LOC100345003
uniprot id: G1SZG7
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9986:WNT11
gene id: 9986:WNT11
uniprot id: Q27Q51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9986:LOC100340253
gene id: 9986:LOC100340253
uniprot id: G1SXW8
names: Similarity
messages: Belongs to the serpin family.

9986:LOC100355890
gene id: 9986:LOC100355890
uniprot id: G1TT82
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9986:LOC100357744
gene id: 9986:LOC100357744
uniprot id: G1SJM2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9986:LOC100350728
gene id: 9986:LOC100350728
uniprot id: A0A5F9DAZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9986:LOC100359029
gene id: 9986:LOC100359029
uniprot id: G1SQU0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9986:LOC100342711
gene id: 9986:LOC100342711
uniprot id: G1T169
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9986:LOC100350077
gene id: 9986:LOC100350077
uniprot id: A0A5F9CMY5
names: Subcellular Location Annotation
messages: Membrane

9986:PABIR1
gene id: 9986:PABIR1
uniprot id: G1SHZ1
names: Similarity
messages: Belongs to the FAM122 family.

9986:LOC103346342
gene id: 9986:LOC103346342
uniprot id: A0A5F9CIP4
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100358703
gene id: 9986:LOC100358703
uniprot id: G1STM8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9986:UCP1
gene id: 9986:UCP1
uniprot id: P14271
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Brown adipose tissue.
messages: Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.
messages: May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane
messages: Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.

9986:LOC100355687
gene id: 9986:LOC100355687
uniprot id: G1TSE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9986:LOC100357656
gene id: 9986:LOC100357656
uniprot id: G1SM48
names: Similarity
messages: Belongs to the BolA/IbaG family.

9986:LOC100339659
gene id: 9986:LOC100339659
uniprot id: A0A5F9D1N6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9986:LOC100355722
gene id: 9986:LOC100355722
uniprot id: G1SWJ0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9986:LOC100359236
gene id: 9986:LOC100359236
uniprot id: G1T956
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9986:LOC100342736
gene id: 9986:LOC100342736
uniprot id: A0A5F9CXN5
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9986:KEF51 p04
gene id: 9986:KEF51_p04
uniprot id: A0A3Q8UF59
uniprot id: O79436
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9986:LOC100350980
gene id: 9986:LOC100350980
uniprot id: G1SR63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9986:LOC100353956
gene id: 9986:LOC100353956
uniprot id: P43348
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Interacts with STEAP3.
messages: Involved in calcium binding and microtubule stabilization.
messages: Undergoes developmental regulation during mammary gland development.

9986:ARG1
gene id: 9986:ARG1
uniprot id: Q95KM0
uniprot id: U3KNA1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts with CMTM6 (By similarity).

9986:ODR4
gene id: 9986:ODR4
uniprot id: G1SRP2
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9986:LOC100348820
gene id: 9986:LOC100348820
uniprot id: G1STB1
names: Similarity
messages: Belongs to the BolA/IbaG family.

9986:LOC100343844
gene id: 9986:LOC100343844
uniprot id: G1U166
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9986:LOC103348902
gene id: 9986:LOC103348902
uniprot id: A0A5F9DAT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9986:LOC100357421
gene id: 9986:LOC100357421
uniprot id: G1SMR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9986:CNMD
gene id: 9986:CNMD
uniprot id: O77770
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
messages: Belongs to the chondromodulin-1 family.
messages: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity).
messages: Endomembrane system
messages: extracellular matrix

9986:PSMD4
gene id: 9986:PSMD4
uniprot id: B7NZD2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9986:LOC100345355
gene id: 9986:LOC100345355
uniprot id: G1TV33
names: Similarity
messages: Belongs to the Bcl-2 family.

9986:ST7
gene id: 9986:ST7
uniprot id: Q09YN2
uniprot id: Q09YN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9986:LOC100355134
gene id: 9986:LOC100355134
uniprot id: A0A5F9CZ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9986:LOC100351194
gene id: 9986:LOC100351194
uniprot id: G1SNR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9986:LOC100358715
gene id: 9986:LOC100358715
uniprot id: G1SWD5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9986:LOC100345603
gene id: 9986:LOC100345603
uniprot id: G1SMM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9986:GPR75
gene id: 9986:GPR75
uniprot id: G1SE47
names: Subcellular Location Annotation
messages: Membrane

9986:LOC100345056
gene id: 9986:LOC100345056
uniprot id: G1U746
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100347371
gene id: 9986:LOC100347371
uniprot id: A0A5F9CNV2
uniprot id: G1T1Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9986:LOC100352287
gene id: 9986:LOC100352287
uniprot id: G1T6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9986:LOC100345964
gene id: 9986:LOC100345964
uniprot id: A0A5F9DL89
uniprot id: G1ST00
names: Similarity
messages: Belongs to the RPAP1 family.

9986:SLC22A7
gene id: 9986:SLC22A7
uniprot id: Q3YAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Mediates sodium-independent multispecific organic anion transport.

9986:LOC100338328
gene id: 9986:LOC100338328
uniprot id: G1SXT1
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9986:LOC100345186
gene id: 9986:LOC100345186
uniprot id: G1SM72
names: Similarity
messages: Belongs to the KIN17 family.

9986:LOC100350515
gene id: 9986:LOC100350515
uniprot id: G1U0S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9986:LOC100347232
gene id: 9986:LOC100347232
uniprot id: G1THB5
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9986:LOC100357053
gene id: 9986:LOC100357053
uniprot id: G1SWM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100356051
gene id: 9986:LOC100356051
uniprot id: G1SEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9986:LOC100341839
gene id: 9986:LOC100341839
uniprot id: G1T5P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100340642
gene id: 9986:LOC100340642
uniprot id: A0A5F9C4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9986:LOC103349087
gene id: 9986:LOC103349087
uniprot id: G1SH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100342472
gene id: 9986:LOC100342472
uniprot id: A0A5F9CL43
uniprot id: G1STQ3
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9986:LOC100351855
gene id: 9986:LOC100351855
uniprot id: G1SR69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9986:WFDC2
gene id: 9986:WFDC2
uniprot id: Q28631
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Broad range protease inhibitor.
messages: Epididymis.
messages: Homotrimer; disulfide-linked.
messages: Secreted

9986:LOC100344823
gene id: 9986:LOC100344823
uniprot id: A0A5F9CE70
uniprot id: G1SG00
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

9986:LOC100354426
gene id: 9986:LOC100354426
uniprot id: G1T6G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9986:LOC100350091
gene id: 9986:LOC100350091
uniprot id: G1T0Z2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9986:LOC100355549
gene id: 9986:LOC100355549
uniprot id: G1SZI7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9986:LOC100350113
gene id: 9986:LOC100350113
uniprot id: G1SKS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9986:LOC100340684
gene id: 9986:LOC100340684
uniprot id: G1TCE2
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9986:LOC100352155
gene id: 9986:LOC100352155
uniprot id: G1SV09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9986:LOC100341779
gene id: 9986:LOC100341779
uniprot id: G1U2E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9986:GYG1
gene id: 9986:GYG1
uniprot id: P13280
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
messages: Detected in heart, skeletal muscle, brain and testis, and at lower levels in kidney.
messages: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.
messages: Homodimer (PubMed:12051921, PubMed:15849187, PubMed:22226635, PubMed:22128147). Interacts (via C-terminus) with glycogen synthase GYS1 (By similarity). Interacts (via C-terminus) with glycogen synthase GYS2 (By similarity). This interaction is required for GYS2-mediated glycogen synthesis (By similarity).
messages: Phosphorylated.
messages: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
messages: Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.

9986:LOC100341841
gene id: 9986:LOC100341841
uniprot id: A0A5F9CDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9986:LOC100354969
gene id: 9986:LOC100354969
uniprot id: G1SSV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9986:LOC100342212
gene id: 9986:LOC100342212
uniprot id: A0A5F9CNZ9
uniprot id: A0A5F9CSP7
uniprot id: A0A5F9DCK4
uniprot id: G1SK25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Cell membrane
messages: Membrane

9986:LOC103351681
gene id: 9986:LOC103351681
uniprot id: G1U3E1
names: Similarity
messages: Belongs to the MS4A family.

9986:DPPA5
gene id: 9986:DPPA5
uniprot id: B7NZC1
names: Similarity
messages: Belongs to the KHDC1 family.

9986:LOC100338690
gene id: 9986:LOC100338690
uniprot id: G1T2A6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9986:CD4
gene id: 9986:CD4
uniprot id: P46630
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
messages: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
messages: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization.
messages: The Ig-like V-type domain mediates the interaction with MHCII.

9986:LOC100351529
gene id: 9986:LOC100351529
uniprot id: G1TCF3
names: Similarity
messages: Belongs to the nucleoplasmin family.

9986:LOC100338310
gene id: 9986:LOC100338310
uniprot id: G1SEV4
names: Subcellular Location Annotation
messages: Nucleus

9986:LOC100350080
gene id: 9986:LOC100350080
uniprot id: A0A5F9C407
uniprot id: A0A5F9CPQ4
uniprot id: A0A5F9DEB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9986:LOC100354067
gene id: 9986:LOC100354067
uniprot id: A0A5F9CHG9
uniprot id: G1TED1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9986:LOC100342119
gene id: 9986:LOC100342119
uniprot id: G1T960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane